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Network neighborhood for query Sequence : CASL_HUMAN

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CASL_HUMAN
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CASL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	259	Target Neighborhood Hits	259	Shared Neighborhood Hits	259
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0 (rank : 2)	NC score	0.977992 (rank : 2)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	178
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

BCAR1_HUMAN
θ value	5.41814e-138 (rank : 3)	NC score	0.860937 (rank : 4)
Query Neighborhood Hits	259	Target Neighborhood Hits	554	Shared Neighborhood Hits	178
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	5.07123e-136 (rank : 4)	NC score	0.890661 (rank : 3)
Query Neighborhood Hits	259	Target Neighborhood Hits	438	Shared Neighborhood Hits	165
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT032_HUMAN
θ value	1.27544e-62 (rank : 5)	NC score	0.851679 (rank : 5)
Query Neighborhood Hits	259	Target Neighborhood Hits	235	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EFS_HUMAN
θ value	2.51237e-26 (rank : 6)	NC score	0.718506 (rank : 6)
Query Neighborhood Hits	259	Target Neighborhood Hits	348	Shared Neighborhood Hits	147
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	1.05554e-24 (rank : 7)	NC score	0.701900 (rank : 7)
Query Neighborhood Hits	259	Target Neighborhood Hits	389	Shared Neighborhood Hits	150
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN1_HUMAN
θ value	2.21117e-06 (rank : 8)	NC score	0.264331 (rank : 79)
Query Neighborhood Hits	259	Target Neighborhood Hits	1757	Shared Neighborhood Hits	185
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	4.92598e-06 (rank : 9)	NC score	0.266170 (rank : 78)
Query Neighborhood Hits	259	Target Neighborhood Hits	1669	Shared Neighborhood Hits	179
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SH3G2_MOUSE
θ value	1.43324e-05 (rank : 10)	NC score	0.405509 (rank : 16)
Query Neighborhood Hits	259	Target Neighborhood Hits	319	Shared Neighborhood Hits	149
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

M3K11_HUMAN
θ value	1.87187e-05 (rank : 11)	NC score	0.115133 (rank : 151)
Query Neighborhood Hits	259	Target Neighborhood Hits	1136	Shared Neighborhood Hits	159
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

IASPP_MOUSE
θ value	2.44474e-05 (rank : 12)	NC score	0.292560 (rank : 66)
Query Neighborhood Hits	259	Target Neighborhood Hits	1024	Shared Neighborhood Hits	162
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

HCLS1_HUMAN
θ value	5.44631e-05 (rank : 13)	NC score	0.428256 (rank : 12)
Query Neighborhood Hits	259	Target Neighborhood Hits	358	Shared Neighborhood Hits	154
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G2_HUMAN
θ value	5.44631e-05 (rank : 14)	NC score	0.395823 (rank : 19)
Query Neighborhood Hits	259	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

IASPP_HUMAN
θ value	7.1131e-05 (rank : 15)	NC score	0.306497 (rank : 55)
Query Neighborhood Hits	259	Target Neighborhood Hits	688	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PEX13_MOUSE
θ value	9.29e-05 (rank : 16)	NC score	0.416197 (rank : 13)
Query Neighborhood Hits	259	Target Neighborhood Hits	126	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PPIP1_MOUSE
θ value	0.000121331 (rank : 17)	NC score	0.400664 (rank : 17)
Query Neighborhood Hits	259	Target Neighborhood Hits	377	Shared Neighborhood Hits	153
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PEX13_HUMAN
θ value	0.00020696 (rank : 18)	NC score	0.412103 (rank : 15)
Query Neighborhood Hits	259	Target Neighborhood Hits	128	Shared Neighborhood Hits	100
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

HCLS1_MOUSE
θ value	0.000270298 (rank : 19)	NC score	0.413350 (rank : 14)
Query Neighborhood Hits	259	Target Neighborhood Hits	329	Shared Neighborhood Hits	152
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MYO1F_HUMAN
θ value	0.000270298 (rank : 20)	NC score	0.180536 (rank : 115)
Query Neighborhood Hits	259	Target Neighborhood Hits	275	Shared Neighborhood Hits	142
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	0.000270298 (rank : 21)	NC score	0.180114 (rank : 116)
Query Neighborhood Hits	259	Target Neighborhood Hits	262	Shared Neighborhood Hits	141
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PPIP1_HUMAN
θ value	0.000270298 (rank : 22)	NC score	0.398168 (rank : 18)
Query Neighborhood Hits	259	Target Neighborhood Hits	389	Shared Neighborhood Hits	153
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ITSN2_HUMAN
θ value	0.00035302 (rank : 23)	NC score	0.271003 (rank : 77)
Query Neighborhood Hits	259	Target Neighborhood Hits	1173	Shared Neighborhood Hits	169
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SH3K1_HUMAN
θ value	0.00035302 (rank : 24)	NC score	0.434221 (rank : 11)
Query Neighborhood Hits	259	Target Neighborhood Hits	341	Shared Neighborhood Hits	149
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ASPP1_HUMAN
θ value	0.000461057 (rank : 25)	NC score	0.258330 (rank : 82)
Query Neighborhood Hits	259	Target Neighborhood Hits	956	Shared Neighborhood Hits	155
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ITSN2_MOUSE
θ value	0.000461057 (rank : 26)	NC score	0.256570 (rank : 84)
Query Neighborhood Hits	259	Target Neighborhood Hits	1371	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SH3G1_MOUSE
θ value	0.000461057 (rank : 27)	NC score	0.383147 (rank : 21)
Query Neighborhood Hits	259	Target Neighborhood Hits	291	Shared Neighborhood Hits	146
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3K1_MOUSE
θ value	0.000461057 (rank : 28)	NC score	0.435047 (rank : 10)
Query Neighborhood Hits	259	Target Neighborhood Hits	332	Shared Neighborhood Hits	152
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_HUMAN
θ value	0.000602161 (rank : 29)	NC score	0.438549 (rank : 9)
Query Neighborhood Hits	259	Target Neighborhood Hits	315	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	0.000602161 (rank : 30)	NC score	0.449150 (rank : 8)
Query Neighborhood Hits	259	Target Neighborhood Hits	336	Shared Neighborhood Hits	156
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3G3_HUMAN
θ value	0.000602161 (rank : 31)	NC score	0.382110 (rank : 22)
Query Neighborhood Hits	259	Target Neighborhood Hits	222	Shared Neighborhood Hits	143
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SPTA2_HUMAN
θ value	0.000602161 (rank : 32)	NC score	0.174256 (rank : 118)
Query Neighborhood Hits	259	Target Neighborhood Hits	888	Shared Neighborhood Hits	150
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DNMBP_HUMAN
θ value	0.000786445 (rank : 33)	NC score	0.338309 (rank : 39)
Query Neighborhood Hits	259	Target Neighborhood Hits	413	Shared Neighborhood Hits	148
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ASPP1_MOUSE
θ value	0.00175202 (rank : 34)	NC score	0.251183 (rank : 89)
Query Neighborhood Hits	259	Target Neighborhood Hits	1244	Shared Neighborhood Hits	175
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

M3KL4_HUMAN
θ value	0.00175202 (rank : 35)	NC score	0.121126 (rank : 146)
Query Neighborhood Hits	259	Target Neighborhood Hits	1087	Shared Neighborhood Hits	149
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

VAV_HUMAN
θ value	0.00175202 (rank : 36)	NC score	0.288047 (rank : 68)
Query Neighborhood Hits	259	Target Neighborhood Hits	452	Shared Neighborhood Hits	147
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DNMBP_MOUSE
θ value	0.00228821 (rank : 37)	NC score	0.327121 (rank : 44)
Query Neighborhood Hits	259	Target Neighborhood Hits	435	Shared Neighborhood Hits	153
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GAB1_MOUSE
θ value	0.00228821 (rank : 38)	NC score	0.096138 (rank : 160)
Query Neighborhood Hits	259	Target Neighborhood Hits	233	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

STAC_HUMAN
θ value	0.00228821 (rank : 39)	NC score	0.338900 (rank : 38)
Query Neighborhood Hits	259	Target Neighborhood Hits	276	Shared Neighborhood Hits	134
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV_MOUSE
θ value	0.00228821 (rank : 40)	NC score	0.286321 (rank : 69)
Query Neighborhood Hits	259	Target Neighborhood Hits	430	Shared Neighborhood Hits	146
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SH3G3_MOUSE
θ value	0.00298849 (rank : 41)	NC score	0.371972 (rank : 25)
Query Neighborhood Hits	259	Target Neighborhood Hits	236	Shared Neighborhood Hits	144
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

GRAP2_MOUSE
θ value	0.00390308 (rank : 42)	NC score	0.345315 (rank : 34)
Query Neighborhood Hits	259	Target Neighborhood Hits	297	Shared Neighborhood Hits	147
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCK1_HUMAN
θ value	0.00390308 (rank : 43)	NC score	0.339595 (rank : 36)
Query Neighborhood Hits	259	Target Neighborhood Hits	312	Shared Neighborhood Hits	149
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

OSTF1_MOUSE
θ value	0.00509761 (rank : 44)	NC score	0.283703 (rank : 72)
Query Neighborhood Hits	259	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ARHG7_HUMAN
θ value	0.00665767 (rank : 45)	NC score	0.331023 (rank : 43)
Query Neighborhood Hits	259	Target Neighborhood Hits	347	Shared Neighborhood Hits	148
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CRK_MOUSE
θ value	0.00665767 (rank : 46)	NC score	0.314914 (rank : 52)
Query Neighborhood Hits	259	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

OSTF1_HUMAN
θ value	0.00665767 (rank : 47)	NC score	0.283871 (rank : 71)
Query Neighborhood Hits	259	Target Neighborhood Hits	466	Shared Neighborhood Hits	148
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ABI2_HUMAN
θ value	0.00869519 (rank : 48)	NC score	0.356573 (rank : 30)
Query Neighborhood Hits	259	Target Neighborhood Hits	350	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.00869519 (rank : 49)	NC score	0.357613 (rank : 28)
Query Neighborhood Hits	259	Target Neighborhood Hits	266	Shared Neighborhood Hits	141
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ASPP2_HUMAN
θ value	0.00869519 (rank : 50)	NC score	0.211879 (rank : 106)
Query Neighborhood Hits	259	Target Neighborhood Hits	1156	Shared Neighborhood Hits	147
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

GRB2_HUMAN
θ value	0.00869519 (rank : 51)	NC score	0.345761 (rank : 32)
Query Neighborhood Hits	259	Target Neighborhood Hits	310	Shared Neighborhood Hits	150
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00869519 (rank : 52)	NC score	0.345550 (rank : 33)
Query Neighborhood Hits	259	Target Neighborhood Hits	312	Shared Neighborhood Hits	150
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF1_HUMAN
θ value	0.0113563 (rank : 53)	NC score	0.359599 (rank : 27)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	125
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RHG04_HUMAN
θ value	0.0113563 (rank : 54)	NC score	0.206921 (rank : 108)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STAC_MOUSE
θ value	0.0113563 (rank : 55)	NC score	0.321668 (rank : 50)
Query Neighborhood Hits	259	Target Neighborhood Hits	268	Shared Neighborhood Hits	132
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CIKS_HUMAN
θ value	0.0148317 (rank : 56)	NC score	0.111155 (rank : 153)
Query Neighborhood Hits	259	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CRKL_HUMAN
θ value	0.0148317 (rank : 57)	NC score	0.323008 (rank : 48)
Query Neighborhood Hits	259	Target Neighborhood Hits	313	Shared Neighborhood Hits	149
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GAB1_HUMAN
θ value	0.0148317 (rank : 58)	NC score	0.093287 (rank : 163)
Query Neighborhood Hits	259	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

SH3G1_HUMAN
θ value	0.0148317 (rank : 59)	NC score	0.352438 (rank : 31)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	144
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

WNK2_HUMAN
θ value	0.0148317 (rank : 60)	NC score	0.030888 (rank : 330)
Query Neighborhood Hits	259	Target Neighborhood Hits	1407	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

GRAP2_HUMAN
θ value	0.0193708 (rank : 61)	NC score	0.333350 (rank : 41)
Query Neighborhood Hits	259	Target Neighborhood Hits	304	Shared Neighborhood Hits	147
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_MOUSE
θ value	0.0193708 (rank : 62)	NC score	0.323944 (rank : 46)
Query Neighborhood Hits	259	Target Neighborhood Hits	309	Shared Neighborhood Hits	150
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1E_HUMAN
θ value	0.0193708 (rank : 63)	NC score	0.164065 (rank : 122)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	137
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NCF2_HUMAN
θ value	0.0193708 (rank : 64)	NC score	0.383193 (rank : 20)
Query Neighborhood Hits	259	Target Neighborhood Hits	229	Shared Neighborhood Hits	127
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ARHG9_HUMAN
θ value	0.0252991 (rank : 65)	NC score	0.253291 (rank : 87)
Query Neighborhood Hits	259	Target Neighborhood Hits	235	Shared Neighborhood Hits	128
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

CRKL_MOUSE
θ value	0.0252991 (rank : 66)	NC score	0.303417 (rank : 58)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	145
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SRC8_MOUSE
θ value	0.0252991 (rank : 67)	NC score	0.373247 (rank : 23)
Query Neighborhood Hits	259	Target Neighborhood Hits	292	Shared Neighborhood Hits	146
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ARHG7_MOUSE
θ value	0.0330416 (rank : 68)	NC score	0.324660 (rank : 45)
Query Neighborhood Hits	259	Target Neighborhood Hits	396	Shared Neighborhood Hits	152
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

M3K10_HUMAN
θ value	0.0330416 (rank : 69)	NC score	0.091888 (rank : 164)
Query Neighborhood Hits	259	Target Neighborhood Hits	1071	Shared Neighborhood Hits	138
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
θ value	0.0330416 (rank : 70)	NC score	0.102358 (rank : 156)
Query Neighborhood Hits	259	Target Neighborhood Hits	1123	Shared Neighborhood Hits	146
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRC8_HUMAN
θ value	0.0330416 (rank : 71)	NC score	0.373077 (rank : 24)
Query Neighborhood Hits	259	Target Neighborhood Hits	269	Shared Neighborhood Hits	141
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

TITIN_HUMAN
θ value	0.0330416 (rank : 72)	NC score	0.024143 (rank : 343)
Query Neighborhood Hits	259	Target Neighborhood Hits	2923	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NCF1_MOUSE
θ value	0.0431538 (rank : 73)	NC score	0.341620 (rank : 35)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ARHG9_MOUSE
θ value	0.0563607 (rank : 74)	NC score	0.250703 (rank : 90)
Query Neighborhood Hits	259	Target Neighborhood Hits	234	Shared Neighborhood Hits	129
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CRK_HUMAN
θ value	0.0563607 (rank : 75)	NC score	0.297008 (rank : 62)
Query Neighborhood Hits	259	Target Neighborhood Hits	308	Shared Neighborhood Hits	149
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MATK_HUMAN
θ value	0.0563607 (rank : 76)	NC score	0.047303 (rank : 308)
Query Neighborhood Hits	259	Target Neighborhood Hits	954	Shared Neighborhood Hits	66
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

BTK_HUMAN
θ value	0.0736092 (rank : 77)	NC score	0.083880 (rank : 173)
Query Neighborhood Hits	259	Target Neighborhood Hits	1026	Shared Neighborhood Hits	146
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

GRAP_HUMAN
θ value	0.0736092 (rank : 78)	NC score	0.316161 (rank : 51)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
θ value	0.0736092 (rank : 79)	NC score	0.323497 (rank : 47)
Query Neighborhood Hits	259	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RUSC1_HUMAN
θ value	0.0736092 (rank : 80)	NC score	0.264030 (rank : 80)
Query Neighborhood Hits	259	Target Neighborhood Hits	226	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STAM2_MOUSE
θ value	0.0736092 (rank : 81)	NC score	0.304666 (rank : 57)
Query Neighborhood Hits	259	Target Neighborhood Hits	285	Shared Neighborhood Hits	148
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TAB3_HUMAN
θ value	0.0736092 (rank : 82)	NC score	0.068586 (rank : 208)
Query Neighborhood Hits	259	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

AHI1_MOUSE
θ value	0.0961366 (rank : 83)	NC score	0.252645 (rank : 88)
Query Neighborhood Hits	259	Target Neighborhood Hits	496	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NPHP1_HUMAN
θ value	0.0961366 (rank : 84)	NC score	0.272159 (rank : 76)
Query Neighborhood Hits	259	Target Neighborhood Hits	288	Shared Neighborhood Hits	128
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	0.0961366 (rank : 85)	NC score	0.300130 (rank : 60)
Query Neighborhood Hits	259	Target Neighborhood Hits	267	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RIMB1_HUMAN
θ value	0.0961366 (rank : 86)	NC score	0.142061 (rank : 136)
Query Neighborhood Hits	259	Target Neighborhood Hits	1479	Shared Neighborhood Hits	148
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRBS1_MOUSE
θ value	0.0961366 (rank : 87)	NC score	0.339578 (rank : 37)
Query Neighborhood Hits	259	Target Neighborhood Hits	409	Shared Neighborhood Hits	151
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CEL_HUMAN
θ value	0.125558 (rank : 88)	NC score	0.035392 (rank : 323)
Query Neighborhood Hits	259	Target Neighborhood Hits	896	Shared Neighborhood Hits	51
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SRBS1_HUMAN
θ value	0.125558 (rank : 89)	NC score	0.336062 (rank : 40)
Query Neighborhood Hits	259	Target Neighborhood Hits	396	Shared Neighborhood Hits	152
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

AHI1_HUMAN
θ value	0.163984 (rank : 90)	NC score	0.260049 (rank : 81)
Query Neighborhood Hits	259	Target Neighborhood Hits	537	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG6_HUMAN
θ value	0.163984 (rank : 91)	NC score	0.293335 (rank : 65)
Query Neighborhood Hits	259	Target Neighborhood Hits	376	Shared Neighborhood Hits	145
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.163984 (rank : 92)	NC score	0.299104 (rank : 61)
Query Neighborhood Hits	259	Target Neighborhood Hits	394	Shared Neighborhood Hits	148
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARI1B_HUMAN
θ value	0.163984 (rank : 93)	NC score	0.060288 (rank : 235)
Query Neighborhood Hits	259	Target Neighborhood Hits	567	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

SPTA1_HUMAN
θ value	0.163984 (rank : 94)	NC score	0.151184 (rank : 127)
Query Neighborhood Hits	259	Target Neighborhood Hits	748	Shared Neighborhood Hits	142
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SYN1_MOUSE
θ value	0.163984 (rank : 95)	NC score	0.060091 (rank : 236)
Query Neighborhood Hits	259	Target Neighborhood Hits	363	Shared Neighborhood Hits	26
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

ZN516_HUMAN
θ value	0.163984 (rank : 96)	NC score	0.002553 (rank : 390)
Query Neighborhood Hits	259	Target Neighborhood Hits	854	Shared Neighborhood Hits	13
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.

ABI1_MOUSE
θ value	0.21417 (rank : 97)	NC score	0.322233 (rank : 49)
Query Neighborhood Hits	259	Target Neighborhood Hits	246	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ARHG4_HUMAN
θ value	0.21417 (rank : 98)	NC score	0.233067 (rank : 93)
Query Neighborhood Hits	259	Target Neighborhood Hits	242	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GGN_MOUSE
θ value	0.21417 (rank : 99)	NC score	0.056566 (rank : 256)
Query Neighborhood Hits	259	Target Neighborhood Hits	311	Shared Neighborhood Hits	21
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MTF1_HUMAN
θ value	0.21417 (rank : 100)	NC score	0.000216 (rank : 391)
Query Neighborhood Hits	259	Target Neighborhood Hits	814	Shared Neighborhood Hits	10
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

RIMB1_MOUSE
θ value	0.21417 (rank : 101)	NC score	0.129130 (rank : 145)
Query Neighborhood Hits	259	Target Neighborhood Hits	1376	Shared Neighborhood Hits	166
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TAB3_MOUSE
θ value	0.21417 (rank : 102)	NC score	0.077372 (rank : 189)
Query Neighborhood Hits	259	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

BTK_MOUSE
θ value	0.279714 (rank : 103)	NC score	0.076536 (rank : 191)
Query Neighborhood Hits	259	Target Neighborhood Hits	1017	Shared Neighborhood Hits	138
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CSTFT_MOUSE
θ value	0.279714 (rank : 104)	NC score	0.022172 (rank : 352)
Query Neighborhood Hits	259	Target Neighborhood Hits	356	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

MAGD1_MOUSE
θ value	0.279714 (rank : 105)	NC score	0.022462 (rank : 350)
Query Neighborhood Hits	259	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

SRGP1_HUMAN
θ value	0.279714 (rank : 106)	NC score	0.143041 (rank : 134)
Query Neighborhood Hits	259	Target Neighborhood Hits	390	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAM1_HUMAN
θ value	0.279714 (rank : 107)	NC score	0.308441 (rank : 53)
Query Neighborhood Hits	259	Target Neighborhood Hits	271	Shared Neighborhood Hits	148
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.279714 (rank : 108)	NC score	0.306089 (rank : 56)
Query Neighborhood Hits	259	Target Neighborhood Hits	273	Shared Neighborhood Hits	148
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI1_HUMAN
θ value	0.365318 (rank : 109)	NC score	0.307663 (rank : 54)
Query Neighborhood Hits	259	Target Neighborhood Hits	257	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

G3BP_MOUSE
θ value	0.365318 (rank : 110)	NC score	0.036443 (rank : 321)
Query Neighborhood Hits	259	Target Neighborhood Hits	209	Shared Neighborhood Hits	12
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

NFIC_HUMAN
θ value	0.365318 (rank : 111)	NC score	0.020307 (rank : 353)
Query Neighborhood Hits	259	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P08651, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1	Gene names	NFIC, NFI
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

SNX9_MOUSE
θ value	0.365318 (rank : 112)	NC score	0.146056 (rank : 130)
Query Neighborhood Hits	259	Target Neighborhood Hits	141	Shared Neighborhood Hits	75
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRMS_HUMAN
θ value	0.365318 (rank : 113)	NC score	0.044563 (rank : 314)
Query Neighborhood Hits	259	Target Neighborhood Hits	946	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

VAV2_HUMAN
θ value	0.365318 (rank : 114)	NC score	0.233027 (rank : 94)
Query Neighborhood Hits	259	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.365318 (rank : 115)	NC score	0.232808 (rank : 95)
Query Neighborhood Hits	259	Target Neighborhood Hits	456	Shared Neighborhood Hits	144
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DLG5_HUMAN
θ value	0.47712 (rank : 116)	NC score	0.051649 (rank : 285)
Query Neighborhood Hits	259	Target Neighborhood Hits	1088	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FRK_HUMAN
θ value	0.47712 (rank : 117)	NC score	0.071888 (rank : 202)
Query Neighborhood Hits	259	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

RGS3_MOUSE
θ value	0.47712 (rank : 118)	NC score	0.071122 (rank : 204)
Query Neighborhood Hits	259	Target Neighborhood Hits	1621	Shared Neighborhood Hits	93
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RTN1_MOUSE
θ value	0.47712 (rank : 119)	NC score	0.031060 (rank : 329)
Query Neighborhood Hits	259	Target Neighborhood Hits	189	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SF3A2_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.085240 (rank : 170)
Query Neighborhood Hits	259	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

VINEX_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.360632 (rank : 26)
Query Neighborhood Hits	259	Target Neighborhood Hits	286	Shared Neighborhood Hits	149
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

CO1A1_MOUSE
θ value	0.62314 (rank : 122)	NC score	0.018477 (rank : 356)
Query Neighborhood Hits	259	Target Neighborhood Hits	457	Shared Neighborhood Hits	22
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

ES8L3_MOUSE
θ value	0.62314 (rank : 123)	NC score	0.197860 (rank : 111)
Query Neighborhood Hits	259	Target Neighborhood Hits	168	Shared Neighborhood Hits	110
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EWS_HUMAN
θ value	0.62314 (rank : 124)	NC score	0.043410 (rank : 316)
Query Neighborhood Hits	259	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

EWS_MOUSE
θ value	0.62314 (rank : 125)	NC score	0.045628 (rank : 312)
Query Neighborhood Hits	259	Target Neighborhood Hits	271	Shared Neighborhood Hits	16
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

MAGD1_HUMAN
θ value	0.62314 (rank : 126)	NC score	0.026578 (rank : 336)
Query Neighborhood Hits	259	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

MPP5_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.054455 (rank : 266)
Query Neighborhood Hits	259	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.62314 (rank : 128)	NC score	0.054096 (rank : 268)
Query Neighborhood Hits	259	Target Neighborhood Hits	226	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NCF4_MOUSE
θ value	0.62314 (rank : 129)	NC score	0.332473 (rank : 42)
Query Neighborhood Hits	259	Target Neighborhood Hits	177	Shared Neighborhood Hits	124
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN2_MOUSE
θ value	0.62314 (rank : 130)	NC score	0.293336 (rank : 64)
Query Neighborhood Hits	259	Target Neighborhood Hits	382	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG1_MOUSE
θ value	0.62314 (rank : 131)	NC score	0.192940 (rank : 113)
Query Neighborhood Hits	259	Target Neighborhood Hits	314	Shared Neighborhood Hits	125
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RABE1_HUMAN
θ value	0.62314 (rank : 132)	NC score	0.026478 (rank : 337)
Query Neighborhood Hits	259	Target Neighborhood Hits	1104	Shared Neighborhood Hits	45
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

SRC_HUMAN
θ value	0.62314 (rank : 133)	NC score	0.085315 (rank : 169)
Query Neighborhood Hits	259	Target Neighborhood Hits	1058	Shared Neighborhood Hits	151
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SYN1_HUMAN
θ value	0.62314 (rank : 134)	NC score	0.055681 (rank : 261)
Query Neighborhood Hits	259	Target Neighborhood Hits	419	Shared Neighborhood Hits	25
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

TRML1_MOUSE
θ value	0.62314 (rank : 135)	NC score	0.040282 (rank : 319)
Query Neighborhood Hits	259	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K558, Q9D3N6	Gene names	Treml1, Tlt1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

VINEX_HUMAN
θ value	0.62314 (rank : 136)	NC score	0.357291 (rank : 29)
Query Neighborhood Hits	259	Target Neighborhood Hits	270	Shared Neighborhood Hits	146
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

EPS8_MOUSE
θ value	0.813845 (rank : 137)	NC score	0.164751 (rank : 121)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L2_MOUSE
θ value	0.813845 (rank : 138)	NC score	0.155291 (rank : 126)
Query Neighborhood Hits	259	Target Neighborhood Hits	169	Shared Neighborhood Hits	96
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

G3BP_HUMAN
θ value	0.813845 (rank : 139)	NC score	0.034455 (rank : 324)
Query Neighborhood Hits	259	Target Neighborhood Hits	219	Shared Neighborhood Hits	14
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

NEBU_HUMAN
θ value	0.813845 (rank : 140)	NC score	0.204171 (rank : 109)
Query Neighborhood Hits	259	Target Neighborhood Hits	420	Shared Neighborhood Hits	137
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PACN2_HUMAN
θ value	0.813845 (rank : 141)	NC score	0.296495 (rank : 63)
Query Neighborhood Hits	259	Target Neighborhood Hits	339	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	0.813845 (rank : 142)	NC score	0.277284 (rank : 75)
Query Neighborhood Hits	259	Target Neighborhood Hits	385	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.813845 (rank : 143)	NC score	0.278656 (rank : 74)
Query Neighborhood Hits	259	Target Neighborhood Hits	380	Shared Neighborhood Hits	137
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

RUSC1_MOUSE
θ value	0.813845 (rank : 144)	NC score	0.232590 (rank : 96)
Query Neighborhood Hits	259	Target Neighborhood Hits	206	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

YES_HUMAN
θ value	0.813845 (rank : 145)	NC score	0.084834 (rank : 171)
Query Neighborhood Hits	259	Target Neighborhood Hits	1059	Shared Neighborhood Hits	144
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.813845 (rank : 146)	NC score	0.085489 (rank : 168)
Query Neighborhood Hits	259	Target Neighborhood Hits	1052	Shared Neighborhood Hits	146
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CO1A1_HUMAN
θ value	1.06291 (rank : 147)	NC score	0.017490 (rank : 357)
Query Neighborhood Hits	259	Target Neighborhood Hits	475	Shared Neighborhood Hits	23
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

FMN2_HUMAN
θ value	1.06291 (rank : 148)	NC score	0.041281 (rank : 318)
Query Neighborhood Hits	259	Target Neighborhood Hits	484	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

MATK_MOUSE
θ value	1.06291 (rank : 149)	NC score	0.045915 (rank : 310)
Query Neighborhood Hits	259	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MINT_HUMAN
θ value	1.06291 (rank : 150)	NC score	0.046042 (rank : 309)
Query Neighborhood Hits	259	Target Neighborhood Hits	1291	Shared Neighborhood Hits	67
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PACN1_HUMAN
θ value	1.06291 (rank : 151)	NC score	0.285787 (rank : 70)
Query Neighborhood Hits	259	Target Neighborhood Hits	320	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	1.06291 (rank : 152)	NC score	0.288515 (rank : 67)
Query Neighborhood Hits	259	Target Neighborhood Hits	283	Shared Neighborhood Hits	138
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PLCG1_HUMAN
θ value	1.06291 (rank : 153)	NC score	0.184777 (rank : 114)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PRP2_MOUSE
θ value	1.06291 (rank : 154)	NC score	0.073524 (rank : 197)
Query Neighborhood Hits	259	Target Neighborhood Hits	347	Shared Neighborhood Hits	25
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SNX9_HUMAN
θ value	1.06291 (rank : 155)	NC score	0.156684 (rank : 125)
Query Neighborhood Hits	259	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

TXND2_HUMAN
θ value	1.06291 (rank : 156)	NC score	0.050276 (rank : 299)
Query Neighborhood Hits	259	Target Neighborhood Hits	793	Shared Neighborhood Hits	47
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ALEX_MOUSE
θ value	1.38821 (rank : 157)	NC score	0.037999 (rank : 320)
Query Neighborhood Hits	259	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

CSKI1_HUMAN
θ value	1.38821 (rank : 158)	NC score	0.050277 (rank : 298)
Query Neighborhood Hits	259	Target Neighborhood Hits	997	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ES8L2_HUMAN
θ value	1.38821 (rank : 159)	NC score	0.166627 (rank : 120)
Query Neighborhood Hits	259	Target Neighborhood Hits	193	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

HCK_HUMAN
θ value	1.38821 (rank : 160)	NC score	0.078887 (rank : 185)
Query Neighborhood Hits	259	Target Neighborhood Hits	1035	Shared Neighborhood Hits	140
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KTN1_MOUSE
θ value	1.38821 (rank : 161)	NC score	0.024149 (rank : 342)
Query Neighborhood Hits	259	Target Neighborhood Hits	1324	Shared Neighborhood Hits	52
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

NOXO1_MOUSE
θ value	1.38821 (rank : 162)	NC score	0.256606 (rank : 83)
Query Neighborhood Hits	259	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PGFRB_MOUSE
θ value	1.38821 (rank : 163)	NC score	0.025265 (rank : 339)
Query Neighborhood Hits	259	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

SF3A2_MOUSE
θ value	1.38821 (rank : 164)	NC score	0.082934 (rank : 176)
Query Neighborhood Hits	259	Target Neighborhood Hits	247	Shared Neighborhood Hits	20
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SN1L2_HUMAN
θ value	1.38821 (rank : 165)	NC score	0.014734 (rank : 365)
Query Neighborhood Hits	259	Target Neighborhood Hits	964	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SNX18_MOUSE
θ value	1.38821 (rank : 166)	NC score	0.241165 (rank : 91)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	113
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SPTA1_MOUSE
θ value	1.38821 (rank : 167)	NC score	0.142046 (rank : 137)
Query Neighborhood Hits	259	Target Neighborhood Hits	675	Shared Neighborhood Hits	138
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAM2_HUMAN
θ value	1.38821 (rank : 168)	NC score	0.282151 (rank : 73)
Query Neighborhood Hits	259	Target Neighborhood Hits	288	Shared Neighborhood Hits	145
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG4_MOUSE
θ value	1.81305 (rank : 169)	NC score	0.177529 (rank : 117)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DAZL_MOUSE
θ value	1.81305 (rank : 170)	NC score	0.023373 (rank : 345)
Query Neighborhood Hits	259	Target Neighborhood Hits	152	Shared Neighborhood Hits	8
SwissProt Accessions	Q64368	Gene names	Dazl, Dazl1, Dazla
Domain Architecture
Description	Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1).

DBNL_HUMAN
θ value	1.81305 (rank : 171)	NC score	0.256422 (rank : 85)
Query Neighborhood Hits	259	Target Neighborhood Hits	244	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	1.81305 (rank : 172)	NC score	0.253527 (rank : 86)
Query Neighborhood Hits	259	Target Neighborhood Hits	306	Shared Neighborhood Hits	132
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DNMT1_MOUSE
θ value	1.81305 (rank : 173)	NC score	0.018946 (rank : 355)
Query Neighborhood Hits	259	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

EP15_MOUSE
θ value	1.81305 (rank : 174)	NC score	0.050997 (rank : 290)
Query Neighborhood Hits	259	Target Neighborhood Hits	820	Shared Neighborhood Hits	34
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MLL2_HUMAN
θ value	1.81305 (rank : 175)	NC score	0.047834 (rank : 306)
Query Neighborhood Hits	259	Target Neighborhood Hits	1788	Shared Neighborhood Hits	71
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MTF1_MOUSE
θ value	1.81305 (rank : 176)	NC score	-0.000712 (rank : 392)
Query Neighborhood Hits	259	Target Neighborhood Hits	785	Shared Neighborhood Hits	14
SwissProt Accessions	Q07243	Gene names	Mtf1, Mtf-1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

NEST_HUMAN
θ value	1.81305 (rank : 177)	NC score	0.023607 (rank : 344)
Query Neighborhood Hits	259	Target Neighborhood Hits	1305	Shared Neighborhood Hits	47
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NFAC2_HUMAN
θ value	1.81305 (rank : 178)	NC score	0.016333 (rank : 360)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	13
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

RHG26_HUMAN
θ value	1.81305 (rank : 179)	NC score	0.157950 (rank : 124)
Query Neighborhood Hits	259	Target Neighborhood Hits	281	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ARNT2_HUMAN
θ value	2.36792 (rank : 180)	NC score	0.013827 (rank : 367)
Query Neighborhood Hits	259	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	2.36792 (rank : 181)	NC score	0.014331 (rank : 366)
Query Neighborhood Hits	259	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

BRD4_MOUSE
θ value	2.36792 (rank : 182)	NC score	0.043224 (rank : 317)
Query Neighborhood Hits	259	Target Neighborhood Hits	845	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

KTN1_HUMAN
θ value	2.36792 (rank : 183)	NC score	0.022951 (rank : 347)
Query Neighborhood Hits	259	Target Neighborhood Hits	1197	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NCOR1_MOUSE
θ value	2.36792 (rank : 184)	NC score	0.022753 (rank : 348)
Query Neighborhood Hits	259	Target Neighborhood Hits	521	Shared Neighborhood Hits	28
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

SNX18_HUMAN
θ value	2.36792 (rank : 185)	NC score	0.226170 (rank : 101)
Query Neighborhood Hits	259	Target Neighborhood Hits	207	Shared Neighborhood Hits	113
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV3_HUMAN
θ value	2.36792 (rank : 186)	NC score	0.220962 (rank : 102)
Query Neighborhood Hits	259	Target Neighborhood Hits	398	Shared Neighborhood Hits	143
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

AKAP2_MOUSE
θ value	3.0926 (rank : 187)	NC score	0.030755 (rank : 331)
Query Neighborhood Hits	259	Target Neighborhood Hits	385	Shared Neighborhood Hits	26
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

BRD2_HUMAN
θ value	3.0926 (rank : 188)	NC score	0.022299 (rank : 351)
Query Neighborhood Hits	259	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

CHK1_HUMAN
θ value	3.0926 (rank : 189)	NC score	0.011669 (rank : 371)
Query Neighborhood Hits	259	Target Neighborhood Hits	843	Shared Neighborhood Hits	27
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

DDEF2_HUMAN
θ value	3.0926 (rank : 190)	NC score	0.138193 (rank : 141)
Query Neighborhood Hits	259	Target Neighborhood Hits	599	Shared Neighborhood Hits	132
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EPS8_HUMAN
θ value	3.0926 (rank : 191)	NC score	0.158162 (rank : 123)
Query Neighborhood Hits	259	Target Neighborhood Hits	151	Shared Neighborhood Hits	92
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MAK_MOUSE
θ value	3.0926 (rank : 192)	NC score	0.012155 (rank : 370)
Query Neighborhood Hits	259	Target Neighborhood Hits	873	Shared Neighborhood Hits	30
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MED12_HUMAN
θ value	3.0926 (rank : 193)	NC score	0.029006 (rank : 332)
Query Neighborhood Hits	259	Target Neighborhood Hits	262	Shared Neighborhood Hits	15
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

NEBL_HUMAN
θ value	3.0926 (rank : 194)	NC score	0.234025 (rank : 92)
Query Neighborhood Hits	259	Target Neighborhood Hits	457	Shared Neighborhood Hits	134
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RGS3_HUMAN
θ value	3.0926 (rank : 195)	NC score	0.051428 (rank : 288)
Query Neighborhood Hits	259	Target Neighborhood Hits	1375	Shared Neighborhood Hits	78
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RTN4_MOUSE
θ value	3.0926 (rank : 196)	NC score	0.026820 (rank : 335)
Query Neighborhood Hits	259	Target Neighborhood Hits	341	Shared Neighborhood Hits	24
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SSX4_HUMAN
θ value	3.0926 (rank : 197)	NC score	0.010128 (rank : 373)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	O60224, Q5JQZ0, Q9UJU9	Gene names	SSX4
Domain Architecture
Description	Protein SSX4.

TRDN_HUMAN
θ value	3.0926 (rank : 198)	NC score	0.031171 (rank : 328)
Query Neighborhood Hits	259	Target Neighborhood Hits	542	Shared Neighborhood Hits	20
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

YLPM1_MOUSE
θ value	3.0926 (rank : 199)	NC score	0.045827 (rank : 311)
Query Neighborhood Hits	259	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

APC_MOUSE
θ value	4.03905 (rank : 200)	NC score	0.016042 (rank : 362)
Query Neighborhood Hits	259	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

ATN1_HUMAN
θ value	4.03905 (rank : 201)	NC score	0.069295 (rank : 207)
Query Neighborhood Hits	259	Target Neighborhood Hits	676	Shared Neighborhood Hits	46
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

DDEF2_MOUSE
θ value	4.03905 (rank : 202)	NC score	0.139185 (rank : 140)
Query Neighborhood Hits	259	Target Neighborhood Hits	625	Shared Neighborhood Hits	130
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

KI21B_HUMAN
θ value	4.03905 (rank : 203)	NC score	0.008816 (rank : 384)
Query Neighborhood Hits	259	Target Neighborhood Hits	1017	Shared Neighborhood Hits	37
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

MAP1A_HUMAN
θ value	4.03905 (rank : 204)	NC score	0.031292 (rank : 327)
Query Neighborhood Hits	259	Target Neighborhood Hits	1626	Shared Neighborhood Hits	72
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MCF2L_MOUSE
θ value	4.03905 (rank : 205)	NC score	0.112144 (rank : 152)
Query Neighborhood Hits	259	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MINT_MOUSE
θ value	4.03905 (rank : 206)	NC score	0.049247 (rank : 305)
Query Neighborhood Hits	259	Target Neighborhood Hits	1514	Shared Neighborhood Hits	80
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NOXO1_HUMAN
θ value	4.03905 (rank : 207)	NC score	0.193858 (rank : 112)
Query Neighborhood Hits	259	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PAX9_MOUSE
θ value	4.03905 (rank : 208)	NC score	0.013166 (rank : 368)
Query Neighborhood Hits	259	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

RIMB2_HUMAN
θ value	4.03905 (rank : 209)	NC score	0.211233 (rank : 107)
Query Neighborhood Hits	259	Target Neighborhood Hits	263	Shared Neighborhood Hits	111
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TCGAP_MOUSE
θ value	4.03905 (rank : 210)	NC score	0.142848 (rank : 135)
Query Neighborhood Hits	259	Target Neighborhood Hits	409	Shared Neighborhood Hits	118
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VAV3_MOUSE
θ value	4.03905 (rank : 211)	NC score	0.214422 (rank : 105)
Query Neighborhood Hits	259	Target Neighborhood Hits	404	Shared Neighborhood Hits	142
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BRMS1_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.016059 (rank : 361)
Query Neighborhood Hits	259	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N20	Gene names	Brms1
Domain Architecture	No domain graphic available
Description	Breast cancer metastasis-suppressor 1 homolog.

BSN_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.034173 (rank : 325)
Query Neighborhood Hits	259	Target Neighborhood Hits	1537	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BT2A1_HUMAN
θ value	5.27518 (rank : 214)	NC score	0.003583 (rank : 388)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

CT2NL_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.022580 (rank : 349)
Query Neighborhood Hits	259	Target Neighborhood Hits	1059	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DAB1_HUMAN
θ value	5.27518 (rank : 216)	NC score	0.023202 (rank : 346)
Query Neighborhood Hits	259	Target Neighborhood Hits	219	Shared Neighborhood Hits	20
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DOK1_MOUSE
θ value	5.27518 (rank : 217)	NC score	0.028198 (rank : 333)
Query Neighborhood Hits	259	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

FIBB_HUMAN
θ value	5.27518 (rank : 218)	NC score	0.009609 (rank : 379)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	P02675	Gene names	FGB
Domain Architecture
Description	Fibrinogen beta chain precursor [Contains: Fibrinopeptide B].

ITPR2_HUMAN
θ value	5.27518 (rank : 219)	NC score	0.010045 (rank : 375)
Query Neighborhood Hits	259	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

MAML1_MOUSE
θ value	5.27518 (rank : 220)	NC score	0.024968 (rank : 340)
Query Neighborhood Hits	259	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

NACAM_MOUSE
θ value	5.27518 (rank : 221)	NC score	0.059147 (rank : 243)
Query Neighborhood Hits	259	Target Neighborhood Hits	1866	Shared Neighborhood Hits	95
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NF2L2_HUMAN
θ value	5.27518 (rank : 222)	NC score	0.009830 (rank : 376)
Query Neighborhood Hits	259	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

RBBP6_HUMAN
θ value	5.27518 (rank : 223)	NC score	0.014929 (rank : 364)
Query Neighborhood Hits	259	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RIMB2_MOUSE
θ value	5.27518 (rank : 224)	NC score	0.203240 (rank : 110)
Query Neighborhood Hits	259	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SMG7_MOUSE
θ value	5.27518 (rank : 225)	NC score	0.019413 (rank : 354)
Query Neighborhood Hits	259	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q5RJH6, Q63ZW5, Q6ZQF3	Gene names	Smg7, Est1c, Kiaa0250
Domain Architecture	No domain graphic available
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

SRC_MOUSE
θ value	5.27518 (rank : 226)	NC score	0.071776 (rank : 203)
Query Neighborhood Hits	259	Target Neighborhood Hits	1033	Shared Neighborhood Hits	132
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TRI14_MOUSE
θ value	5.27518 (rank : 227)	NC score	0.006306 (rank : 387)
Query Neighborhood Hits	259	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

ANGL2_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.007014 (rank : 386)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R045	Gene names	Angptl2, Arp2
Domain Architecture
Description	Angiopoietin-related protein 2 precursor (Angiopoietin-like 2).

BRD4_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.044926 (rank : 313)
Query Neighborhood Hits	259	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CE110_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.012423 (rank : 369)
Query Neighborhood Hits	259	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

DUS3L_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.009734 (rank : 378)
Query Neighborhood Hits	259	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q96G46, Q96HM5, Q9BSU4, Q9H877, Q9NPR1	Gene names	DUS3L
Domain Architecture	No domain graphic available
Description	tRNA-dihydrouridine synthase 3-like (EC 1.-.-.-).

FES_HUMAN
θ value	6.88961 (rank : 232)	NC score	0.025457 (rank : 338)
Query Neighborhood Hits	259	Target Neighborhood Hits	978	Shared Neighborhood Hits	42
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FNBP2_HUMAN
θ value	6.88961 (rank : 233)	NC score	0.132337 (rank : 144)
Query Neighborhood Hits	259	Target Neighborhood Hits	432	Shared Neighborhood Hits	124
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

HMMR_MOUSE
θ value	6.88961 (rank : 234)	NC score	0.016893 (rank : 359)
Query Neighborhood Hits	259	Target Neighborhood Hits	1178	Shared Neighborhood Hits	43
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

ITPR2_MOUSE
θ value	6.88961 (rank : 235)	NC score	0.009603 (rank : 380)
Query Neighborhood Hits	259	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

MAGI1_HUMAN
θ value	6.88961 (rank : 236)	NC score	0.009109 (rank : 383)
Query Neighborhood Hits	259	Target Neighborhood Hits	388	Shared Neighborhood Hits	15
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

P53_MOUSE
θ value	6.88961 (rank : 237)	NC score	0.009331 (rank : 382)
Query Neighborhood Hits	259	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P02340, Q9QUP3	Gene names	Tp53, P53, Trp53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53).

PHC1_MOUSE
θ value	6.88961 (rank : 238)	NC score	0.009749 (rank : 377)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

S18L1_HUMAN
θ value	6.88961 (rank : 239)	NC score	0.010879 (rank : 372)
Query Neighborhood Hits	259	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O75177, Q5JXJ3, Q8NE69, Q9BR55, Q9H4K6	Gene names	SS18L1, KIAA0693
Domain Architecture
Description	SS18-like protein 1 (SYT homolog 1).

SRMS_MOUSE
θ value	6.88961 (rank : 240)	NC score	0.049454 (rank : 304)
Query Neighborhood Hits	259	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TARA_HUMAN
θ value	6.88961 (rank : 241)	NC score	0.032376 (rank : 326)
Query Neighborhood Hits	259	Target Neighborhood Hits	1626	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TCGAP_HUMAN
θ value	6.88961 (rank : 242)	NC score	0.143547 (rank : 133)
Query Neighborhood Hits	259	Target Neighborhood Hits	872	Shared Neighborhood Hits	139
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TRHY_HUMAN
θ value	6.88961 (rank : 243)	NC score	0.024448 (rank : 341)
Query Neighborhood Hits	259	Target Neighborhood Hits	1385	Shared Neighborhood Hits	45
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

USH2A_MOUSE
θ value	6.88961 (rank : 244)	NC score	0.002722 (rank : 389)
Query Neighborhood Hits	259	Target Neighborhood Hits	626	Shared Neighborhood Hits	10
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

WASIP_HUMAN
θ value	6.88961 (rank : 245)	NC score	0.061322 (rank : 224)
Query Neighborhood Hits	259	Target Neighborhood Hits	458	Shared Neighborhood Hits	33
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

CSKI1_MOUSE
θ value	8.99809 (rank : 246)	NC score	0.047622 (rank : 307)
Query Neighborhood Hits	259	Target Neighborhood Hits	1031	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FGR_HUMAN
θ value	8.99809 (rank : 247)	NC score	0.081933 (rank : 181)
Query Neighborhood Hits	259	Target Neighborhood Hits	1067	Shared Neighborhood Hits	142
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FOXP2_HUMAN
θ value	8.99809 (rank : 248)	NC score	0.008342 (rank : 385)
Query Neighborhood Hits	259	Target Neighborhood Hits	366	Shared Neighborhood Hits	17
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

HCK_MOUSE
θ value	8.99809 (rank : 249)	NC score	0.073597 (rank : 195)
Query Neighborhood Hits	259	Target Neighborhood Hits	1029	Shared Neighborhood Hits	139
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

INCE_MOUSE
θ value	8.99809 (rank : 250)	NC score	0.028176 (rank : 334)
Query Neighborhood Hits	259	Target Neighborhood Hits	903	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

K1688_MOUSE
θ value	8.99809 (rank : 251)	NC score	0.035695 (rank : 322)
Query Neighborhood Hits	259	Target Neighborhood Hits	188	Shared Neighborhood Hits	19
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

LTBP3_MOUSE
θ value	8.99809 (rank : 252)	NC score	-0.001785 (rank : 393)
Query Neighborhood Hits	259	Target Neighborhood Hits	475	Shared Neighborhood Hits	3
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).

NCF4_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.301488 (rank : 59)
Query Neighborhood Hits	259	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PAX9_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.010066 (rank : 374)
Query Neighborhood Hits	259	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

RBBP6_MOUSE
θ value	8.99809 (rank : 255)	NC score	0.015268 (rank : 363)
Query Neighborhood Hits	259	Target Neighborhood Hits	1014	Shared Neighborhood Hits	38
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

S3TC1_HUMAN
θ value	8.99809 (rank : 256)	NC score	0.043935 (rank : 315)
Query Neighborhood Hits	259	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

SLK_MOUSE
θ value	8.99809 (rank : 257)	NC score	0.017215 (rank : 358)
Query Neighborhood Hits	259	Target Neighborhood Hits	1798	Shared Neighborhood Hits	63
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

WASIP_MOUSE
θ value	8.99809 (rank : 258)	NC score	0.061195 (rank : 227)
Query Neighborhood Hits	259	Target Neighborhood Hits	392	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ZN638_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.009447 (rank : 381)
Query Neighborhood Hits	259	Target Neighborhood Hits	318	Shared Neighborhood Hits	16
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

ABI3_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.227090 (rank : 98)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.228534 (rank : 97)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.053234 (rank : 276)
Query Neighborhood Hits	259	Target Neighborhood Hits	1220	Shared Neighborhood Hits	112
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.053924 (rank : 270)
Query Neighborhood Hits	259	Target Neighborhood Hits	1178	Shared Neighborhood Hits	117
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

AMPH_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.076792 (rank : 190)
Query Neighborhood Hits	259	Target Neighborhood Hits	455	Shared Neighborhood Hits	81
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.072307 (rank : 201)
Query Neighborhood Hits	259	Target Neighborhood Hits	291	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.139306 (rank : 139)
Query Neighborhood Hits	259	Target Neighborhood Hits	175	Shared Neighborhood Hits	115
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.133185 (rank : 143)
Query Neighborhood Hits	259	Target Neighborhood Hits	175	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

APS_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.051452 (rank : 286)
Query Neighborhood Hits	259	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.060944 (rank : 231)
Query Neighborhood Hits	259	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.052063 (rank : 283)
Query Neighborhood Hits	259	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.052066 (rank : 282)
Query Neighborhood Hits	259	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.051434 (rank : 287)
Query Neighborhood Hits	259	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.082275 (rank : 178)
Query Neighborhood Hits	259	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.082153 (rank : 179)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.102052 (rank : 157)
Query Neighborhood Hits	259	Target Neighborhood Hits	172	Shared Neighborhood Hits	71
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.076133 (rank : 192)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.079695 (rank : 184)
Query Neighborhood Hits	259	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.066824 (rank : 213)
Query Neighborhood Hits	259	Target Neighborhood Hits	187	Shared Neighborhood Hits	23
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.070652 (rank : 206)
Query Neighborhood Hits	259	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.057866 (rank : 250)
Query Neighborhood Hits	259	Target Neighborhood Hits	375	Shared Neighborhood Hits	31
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.057382 (rank : 252)
Query Neighborhood Hits	259	Target Neighborhood Hits	351	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.057110 (rank : 253)
Query Neighborhood Hits	259	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.055824 (rank : 259)
Query Neighborhood Hits	259	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.072435 (rank : 200)
Query Neighborhood Hits	259	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.082722 (rank : 177)
Query Neighborhood Hits	259	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARI1A_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.058989 (rank : 245)
Query Neighborhood Hits	259	Target Neighborhood Hits	787	Shared Neighborhood Hits	53
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

BAIP2_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.050644 (rank : 293)
Query Neighborhood Hits	259	Target Neighborhood Hits	192	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.052860 (rank : 279)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAT2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.054923 (rank : 264)
Query Neighborhood Hits	259	Target Neighborhood Hits	931	Shared Neighborhood Hits	56
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BI2L1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.061060 (rank : 229)
Query Neighborhood Hits	259	Target Neighborhood Hits	156	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.066152 (rank : 215)
Query Neighborhood Hits	259	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.063324 (rank : 219)
Query Neighborhood Hits	259	Target Neighborhood Hits	283	Shared Neighborhood Hits	67
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.061783 (rank : 223)
Query Neighborhood Hits	259	Target Neighborhood Hits	994	Shared Neighborhood Hits	113
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.056153 (rank : 257)
Query Neighborhood Hits	259	Target Neighborhood Hits	992	Shared Neighborhood Hits	105
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CIP4_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.075131 (rank : 193)
Query Neighborhood Hits	259	Target Neighborhood Hits	374	Shared Neighborhood Hits	68
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSK_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.059302 (rank : 240)
Query Neighborhood Hits	259	Target Neighborhood Hits	1009	Shared Neighborhood Hits	117
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.059241 (rank : 241)
Query Neighborhood Hits	259	Target Neighborhood Hits	1009	Shared Neighborhood Hits	117
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.055706 (rank : 260)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.056621 (rank : 255)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.140910 (rank : 138)
Query Neighborhood Hits	259	Target Neighborhood Hits	592	Shared Neighborhood Hits	135
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DOCK1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.073908 (rank : 194)
Query Neighborhood Hits	259	Target Neighborhood Hits	191	Shared Neighborhood Hits	95
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ECT2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.060405 (rank : 234)
Query Neighborhood Hits	259	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.062778 (rank : 220)
Query Neighborhood Hits	259	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.061833 (rank : 222)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.059044 (rank : 244)
Query Neighborhood Hits	259	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ES8L1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.118825 (rank : 147)
Query Neighborhood Hits	259	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.116025 (rank : 150)
Query Neighborhood Hits	259	Target Neighborhood Hits	143	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.138000 (rank : 142)
Query Neighborhood Hits	259	Target Neighborhood Hits	206	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGD1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.057948 (rank : 249)
Query Neighborhood Hits	259	Target Neighborhood Hits	367	Shared Neighborhood Hits	39
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.050459 (rank : 296)
Query Neighborhood Hits	259	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.051797 (rank : 284)
Query Neighborhood Hits	259	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGR_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.078405 (rank : 186)
Query Neighborhood Hits	259	Target Neighborhood Hits	1069	Shared Neighborhood Hits	143
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.082004 (rank : 180)
Query Neighborhood Hits	259	Target Neighborhood Hits	1078	Shared Neighborhood Hits	146
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.083394 (rank : 174)
Query Neighborhood Hits	259	Target Neighborhood Hits	1073	Shared Neighborhood Hits	146
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GNRP_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.050507 (rank : 295)
Query Neighborhood Hits	259	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GSCR1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.057749 (rank : 251)
Query Neighborhood Hits	259	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HAPIP_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.059161 (rank : 242)
Query Neighborhood Hits	259	Target Neighborhood Hits	350	Shared Neighborhood Hits	32
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITK_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.052085 (rank : 281)
Query Neighborhood Hits	259	Target Neighborhood Hits	1016	Shared Neighborhood Hits	111
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LASP1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.217749 (rank : 103)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	121
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.215135 (rank : 104)
Query Neighborhood Hits	259	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBC_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.054143 (rank : 267)
Query Neighborhood Hits	259	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.053757 (rank : 271)
Query Neighborhood Hits	259	Target Neighborhood Hits	987	Shared Neighborhood Hits	95
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.053414 (rank : 274)
Query Neighborhood Hits	259	Target Neighborhood Hits	981	Shared Neighborhood Hits	94
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.054458 (rank : 265)
Query Neighborhood Hits	259	Target Neighborhood Hits	531	Shared Neighborhood Hits	62
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LYN_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.066963 (rank : 212)
Query Neighborhood Hits	259	Target Neighborhood Hits	1022	Shared Neighborhood Hits	128
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.066168 (rank : 214)
Query Neighborhood Hits	259	Target Neighborhood Hits	1023	Shared Neighborhood Hits	129
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MBD6_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.055663 (rank : 262)
Query Neighborhood Hits	259	Target Neighborhood Hits	349	Shared Neighborhood Hits	22
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MCF2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.072814 (rank : 199)
Query Neighborhood Hits	259	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MEPE_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.050342 (rank : 297)
Query Neighborhood Hits	259	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

MPP6_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.052874 (rank : 278)
Query Neighborhood Hits	259	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.050213 (rank : 300)
Query Neighborhood Hits	259	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUC1_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.055167 (rank : 263)
Query Neighborhood Hits	259	Target Neighborhood Hits	975	Shared Neighborhood Hits	60
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUC7_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.050082 (rank : 303)
Query Neighborhood Hits	259	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NGEF_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.094843 (rank : 161)
Query Neighborhood Hits	259	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.098532 (rank : 159)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

OGFR_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.055845 (rank : 258)
Query Neighborhood Hits	259	Target Neighborhood Hits	1582	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

P55G_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.050129 (rank : 302)
Query Neighborhood Hits	259	Target Neighborhood Hits	451	Shared Neighborhood Hits	49
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.050162 (rank : 301)
Query Neighborhood Hits	259	Target Neighborhood Hits	401	Shared Neighborhood Hits	47
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.073562 (rank : 196)
Query Neighborhood Hits	259	Target Neighborhood Hits	479	Shared Neighborhood Hits	86
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.077817 (rank : 188)
Query Neighborhood Hits	259	Target Neighborhood Hits	435	Shared Neighborhood Hits	91
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.064972 (rank : 217)
Query Neighborhood Hits	259	Target Neighborhood Hits	543	Shared Neighborhood Hits	69
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.059970 (rank : 237)
Query Neighborhood Hits	259	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PHC2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.050714 (rank : 292)
Query Neighborhood Hits	259	Target Neighborhood Hits	388	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

PKHG1_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.086771 (rank : 167)
Query Neighborhood Hits	259	Target Neighborhood Hits	174	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCG2_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.171381 (rank : 119)
Query Neighborhood Hits	259	Target Neighborhood Hits	280	Shared Neighborhood Hits	125
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.061303 (rank : 225)
Query Neighborhood Hits	259	Target Neighborhood Hits	254	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.058701 (rank : 246)
Query Neighborhood Hits	259	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.083019 (rank : 175)
Query Neighborhood Hits	259	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRRT3_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.058052 (rank : 248)
Query Neighborhood Hits	259	Target Neighborhood Hits	998	Shared Neighborhood Hits	63
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTK6_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.061241 (rank : 226)
Query Neighborhood Hits	259	Target Neighborhood Hits	1020	Shared Neighborhood Hits	130
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.061000 (rank : 230)
Query Neighborhood Hits	259	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RAPH1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.061968 (rank : 221)
Query Neighborhood Hits	259	Target Neighborhood Hits	593	Shared Neighborhood Hits	47
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.060408 (rank : 233)
Query Neighborhood Hits	259	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RERE_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.053445 (rank : 273)
Query Neighborhood Hits	259	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RERE_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.060730 (rank : 232)
Query Neighborhood Hits	259	Target Neighborhood Hits	785	Shared Neighborhood Hits	40
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.056957 (rank : 254)
Query Neighborhood Hits	259	Target Neighborhood Hits	641	Shared Neighborhood Hits	51
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUSC2_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.108599 (rank : 154)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.088498 (rank : 166)
Query Neighborhood Hits	259	Target Neighborhood Hits	305	Shared Neighborhood Hits	72
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH21B_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.050601 (rank : 294)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.050759 (rank : 291)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.094238 (rank : 162)
Query Neighborhood Hits	259	Target Neighborhood Hits	1041	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.106108 (rank : 155)
Query Neighborhood Hits	259	Target Neighborhood Hits	446	Shared Neighborhood Hits	100
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHC1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.053325 (rank : 275)
Query Neighborhood Hits	259	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHE_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.051389 (rank : 289)
Query Neighborhood Hits	259	Target Neighborhood Hits	169	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.143822 (rank : 132)
Query Neighborhood Hits	259	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.146176 (rank : 129)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.117277 (rank : 149)
Query Neighborhood Hits	259	Target Neighborhood Hits	86	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.118301 (rank : 148)
Query Neighborhood Hits	259	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.061072 (rank : 228)
Query Neighborhood Hits	259	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.059662 (rank : 239)
Query Neighborhood Hits	259	Target Neighborhood Hits	117	Shared Neighborhood Hits	30
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.072830 (rank : 198)
Query Neighborhood Hits	259	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.070822 (rank : 205)
Query Neighborhood Hits	259	Target Neighborhood Hits	136	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.067686 (rank : 211)
Query Neighborhood Hits	259	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.077886 (rank : 187)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SON_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.059688 (rank : 238)
Query Neighborhood Hits	259	Target Neighborhood Hits	1568	Shared Neighborhood Hits	76
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPN90_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.101487 (rank : 158)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.084201 (rank : 172)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPT5H_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.065108 (rank : 216)
Query Neighborhood Hits	259	Target Neighborhood Hits	436	Shared Neighborhood Hits	39
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.064435 (rank : 218)
Query Neighborhood Hits	259	Target Neighborhood Hits	437	Shared Neighborhood Hits	39
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SPTA3_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.053749 (rank : 272)
Query Neighborhood Hits	259	Target Neighborhood Hits	74	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

SRGP2_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.144479 (rank : 131)
Query Neighborhood Hits	259	Target Neighborhood Hits	331	Shared Neighborhood Hits	124
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.149013 (rank : 128)
Query Neighborhood Hits	259	Target Neighborhood Hits	324	Shared Neighborhood Hits	125
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.226852 (rank : 100)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	120
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.227078 (rank : 99)
Query Neighborhood Hits	259	Target Neighborhood Hits	232	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STS1_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.068009 (rank : 209)
Query Neighborhood Hits	259	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.067966 (rank : 210)
Query Neighborhood Hits	259	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.089748 (rank : 165)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	69
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TEC_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.054029 (rank : 269)
Query Neighborhood Hits	259	Target Neighborhood Hits	1006	Shared Neighborhood Hits	116
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.052698 (rank : 280)
Query Neighborhood Hits	259	Target Neighborhood Hits	1006	Shared Neighborhood Hits	116
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.080146 (rank : 183)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.081288 (rank : 182)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	25
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TXK_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.053202 (rank : 277)
Query Neighborhood Hits	259	Target Neighborhood Hits	971	Shared Neighborhood Hits	105
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.058529 (rank : 247)
Query Neighborhood Hits	259	Target Neighborhood Hits	980	Shared Neighborhood Hits	113
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

Hits sorted by NC score

CASL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	259	Target Neighborhood Hits	259	Shared Neighborhood Hits	259
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.977992 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	178
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

BCAR1_MOUSE
NC score	0.890661 (rank : 3)	θ value	5.07123e-136 (rank : 4)
Query Neighborhood Hits	259	Target Neighborhood Hits	438	Shared Neighborhood Hits	165
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.860937 (rank : 4)	θ value	5.41814e-138 (rank : 3)
Query Neighborhood Hits	259	Target Neighborhood Hits	554	Shared Neighborhood Hits	178
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CT032_HUMAN
NC score	0.851679 (rank : 5)	θ value	1.27544e-62 (rank : 5)
Query Neighborhood Hits	259	Target Neighborhood Hits	235	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

EFS_HUMAN
NC score	0.718506 (rank : 6)	θ value	2.51237e-26 (rank : 6)
Query Neighborhood Hits	259	Target Neighborhood Hits	348	Shared Neighborhood Hits	147
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
NC score	0.701900 (rank : 7)	θ value	1.05554e-24 (rank : 7)
Query Neighborhood Hits	259	Target Neighborhood Hits	389	Shared Neighborhood Hits	150
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CD2AP_MOUSE
NC score	0.449150 (rank : 8)	θ value	0.000602161 (rank : 30)
Query Neighborhood Hits	259	Target Neighborhood Hits	336	Shared Neighborhood Hits	156
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.438549 (rank : 9)	θ value	0.000602161 (rank : 29)
Query Neighborhood Hits	259	Target Neighborhood Hits	315	Shared Neighborhood Hits	155
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.435047 (rank : 10)	θ value	0.000461057 (rank : 28)
Query Neighborhood Hits	259	Target Neighborhood Hits	332	Shared Neighborhood Hits	152
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.434221 (rank : 11)	θ value	0.00035302 (rank : 24)
Query Neighborhood Hits	259	Target Neighborhood Hits	341	Shared Neighborhood Hits	149
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

HCLS1_HUMAN
NC score	0.428256 (rank : 12)	θ value	5.44631e-05 (rank : 13)
Query Neighborhood Hits	259	Target Neighborhood Hits	358	Shared Neighborhood Hits	154
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PEX13_MOUSE
NC score	0.416197 (rank : 13)	θ value	9.29e-05 (rank : 16)
Query Neighborhood Hits	259	Target Neighborhood Hits	126	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

HCLS1_MOUSE
NC score	0.413350 (rank : 14)	θ value	0.000270298 (rank : 19)
Query Neighborhood Hits	259	Target Neighborhood Hits	329	Shared Neighborhood Hits	152
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PEX13_HUMAN
NC score	0.412103 (rank : 15)	θ value	0.00020696 (rank : 18)
Query Neighborhood Hits	259	Target Neighborhood Hits	128	Shared Neighborhood Hits	100
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SH3G2_MOUSE
NC score	0.405509 (rank : 16)	θ value	1.43324e-05 (rank : 10)
Query Neighborhood Hits	259	Target Neighborhood Hits	319	Shared Neighborhood Hits	149
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PPIP1_MOUSE
NC score	0.400664 (rank : 17)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	259	Target Neighborhood Hits	377	Shared Neighborhood Hits	153
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PPIP1_HUMAN
NC score	0.398168 (rank : 18)	θ value	0.000270298 (rank : 22)
Query Neighborhood Hits	259	Target Neighborhood Hits	389	Shared Neighborhood Hits	153
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3G2_HUMAN
NC score	0.395823 (rank : 19)	θ value	5.44631e-05 (rank : 14)
Query Neighborhood Hits	259	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NCF2_HUMAN
NC score	0.383193 (rank : 20)	θ value	0.0193708 (rank : 64)
Query Neighborhood Hits	259	Target Neighborhood Hits	229	Shared Neighborhood Hits	127
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G1_MOUSE
NC score	0.383147 (rank : 21)	θ value	0.000461057 (rank : 27)
Query Neighborhood Hits	259	Target Neighborhood Hits	291	Shared Neighborhood Hits	146
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
NC score	0.382110 (rank : 22)	θ value	0.000602161 (rank : 31)
Query Neighborhood Hits	259	Target Neighborhood Hits	222	Shared Neighborhood Hits	143
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRC8_MOUSE
NC score	0.373247 (rank : 23)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	259	Target Neighborhood Hits	292	Shared Neighborhood Hits	146
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.373077 (rank : 24)	θ value	0.0330416 (rank : 71)
Query Neighborhood Hits	259	Target Neighborhood Hits	269	Shared Neighborhood Hits	141
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SH3G3_MOUSE
NC score	0.371972 (rank : 25)	θ value	0.00298849 (rank : 41)
Query Neighborhood Hits	259	Target Neighborhood Hits	236	Shared Neighborhood Hits	144
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VINEX_MOUSE
NC score	0.360632 (rank : 26)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	259	Target Neighborhood Hits	286	Shared Neighborhood Hits	149
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF1_HUMAN
NC score	0.359599 (rank : 27)	θ value	0.0113563 (rank : 53)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	125
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ABI2_MOUSE
NC score	0.357613 (rank : 28)	θ value	0.00869519 (rank : 49)
Query Neighborhood Hits	259	Target Neighborhood Hits	266	Shared Neighborhood Hits	141
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

VINEX_HUMAN
NC score	0.357291 (rank : 29)	θ value	0.62314 (rank : 136)
Query Neighborhood Hits	259	Target Neighborhood Hits	270	Shared Neighborhood Hits	146
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI2_HUMAN
NC score	0.356573 (rank : 30)	θ value	0.00869519 (rank : 48)
Query Neighborhood Hits	259	Target Neighborhood Hits	350	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SH3G1_HUMAN
NC score	0.352438 (rank : 31)	θ value	0.0148317 (rank : 59)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	144
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GRB2_HUMAN
NC score	0.345761 (rank : 32)	θ value	0.00869519 (rank : 51)
Query Neighborhood Hits	259	Target Neighborhood Hits	310	Shared Neighborhood Hits	150
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.345550 (rank : 33)	θ value	0.00869519 (rank : 52)
Query Neighborhood Hits	259	Target Neighborhood Hits	312	Shared Neighborhood Hits	150
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP2_MOUSE
NC score	0.345315 (rank : 34)	θ value	0.00390308 (rank : 42)
Query Neighborhood Hits	259	Target Neighborhood Hits	297	Shared Neighborhood Hits	147
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCF1_MOUSE
NC score	0.341620 (rank : 35)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCK1_HUMAN
NC score	0.339595 (rank : 36)	θ value	0.00390308 (rank : 43)
Query Neighborhood Hits	259	Target Neighborhood Hits	312	Shared Neighborhood Hits	149
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRBS1_MOUSE
NC score	0.339578 (rank : 37)	θ value	0.0961366 (rank : 87)
Query Neighborhood Hits	259	Target Neighborhood Hits	409	Shared Neighborhood Hits	151
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC_HUMAN
NC score	0.338900 (rank : 38)	θ value	0.00228821 (rank : 39)
Query Neighborhood Hits	259	Target Neighborhood Hits	276	Shared Neighborhood Hits	134
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DNMBP_HUMAN
NC score	0.338309 (rank : 39)	θ value	0.000786445 (rank : 33)
Query Neighborhood Hits	259	Target Neighborhood Hits	413	Shared Neighborhood Hits	148
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRBS1_HUMAN
NC score	0.336062 (rank : 40)	θ value	0.125558 (rank : 89)
Query Neighborhood Hits	259	Target Neighborhood Hits	396	Shared Neighborhood Hits	152
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP2_HUMAN
NC score	0.333350 (rank : 41)	θ value	0.0193708 (rank : 61)
Query Neighborhood Hits	259	Target Neighborhood Hits	304	Shared Neighborhood Hits	147
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF4_MOUSE
NC score	0.332473 (rank : 42)	θ value	0.62314 (rank : 129)
Query Neighborhood Hits	259	Target Neighborhood Hits	177	Shared Neighborhood Hits	124
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ARHG7_HUMAN
NC score	0.331023 (rank : 43)	θ value	0.00665767 (rank : 45)
Query Neighborhood Hits	259	Target Neighborhood Hits	347	Shared Neighborhood Hits	148
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
NC score	0.327121 (rank : 44)	θ value	0.00228821 (rank : 37)
Query Neighborhood Hits	259	Target Neighborhood Hits	435	Shared Neighborhood Hits	153
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
NC score	0.324660 (rank : 45)	θ value	0.0330416 (rank : 68)
Query Neighborhood Hits	259	Target Neighborhood Hits	396	Shared Neighborhood Hits	152
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_MOUSE
NC score	0.323944 (rank : 46)	θ value	0.0193708 (rank : 62)
Query Neighborhood Hits	259	Target Neighborhood Hits	309	Shared Neighborhood Hits	150
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.323497 (rank : 47)	θ value	0.0736092 (rank : 79)
Query Neighborhood Hits	259	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CRKL_HUMAN
NC score	0.323008 (rank : 48)	θ value	0.0148317 (rank : 57)
Query Neighborhood Hits	259	Target Neighborhood Hits	313	Shared Neighborhood Hits	149
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ABI1_MOUSE
NC score	0.322233 (rank : 49)	θ value	0.21417 (rank : 97)
Query Neighborhood Hits	259	Target Neighborhood Hits	246	Shared Neighborhood Hits	137
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

STAC_MOUSE
NC score	0.321668 (rank : 50)	θ value	0.0113563 (rank : 55)
Query Neighborhood Hits	259	Target Neighborhood Hits	268	Shared Neighborhood Hits	132
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP_HUMAN
NC score	0.316161 (rank : 51)	θ value	0.0736092 (rank : 78)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CRK_MOUSE
NC score	0.314914 (rank : 52)	θ value	0.00665767 (rank : 46)
Query Neighborhood Hits	259	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAM1_HUMAN
NC score	0.308441 (rank : 53)	θ value	0.279714 (rank : 107)
Query Neighborhood Hits	259	Target Neighborhood Hits	271	Shared Neighborhood Hits	148
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI1_HUMAN
NC score	0.307663 (rank : 54)	θ value	0.365318 (rank : 109)
Query Neighborhood Hits	259	Target Neighborhood Hits	257	Shared Neighborhood Hits	137
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

IASPP_HUMAN
NC score	0.306497 (rank : 55)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	259	Target Neighborhood Hits	688	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

STAM1_MOUSE
NC score	0.306089 (rank : 56)	θ value	0.279714 (rank : 108)
Query Neighborhood Hits	259	Target Neighborhood Hits	273	Shared Neighborhood Hits	148
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.304666 (rank : 57)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	259	Target Neighborhood Hits	285	Shared Neighborhood Hits	148
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CRKL_MOUSE
NC score	0.303417 (rank : 58)	θ value	0.0252991 (rank : 66)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	145
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

NCF4_HUMAN
NC score	0.301488 (rank : 59)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	259	Target Neighborhood Hits	161	Shared Neighborhood Hits	114
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NPHP1_MOUSE
NC score	0.300130 (rank : 60)	θ value	0.0961366 (rank : 85)
Query Neighborhood Hits	259	Target Neighborhood Hits	267	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ARHG6_MOUSE
NC score	0.299104 (rank : 61)	θ value	0.163984 (rank : 92)
Query Neighborhood Hits	259	Target Neighborhood Hits	394	Shared Neighborhood Hits	148
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CRK_HUMAN
NC score	0.297008 (rank : 62)	θ value	0.0563607 (rank : 75)
Query Neighborhood Hits	259	Target Neighborhood Hits	308	Shared Neighborhood Hits	149
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN2_HUMAN
NC score	0.296495 (rank : 63)	θ value	0.813845 (rank : 141)
Query Neighborhood Hits	259	Target Neighborhood Hits	339	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.293336 (rank : 64)	θ value	0.62314 (rank : 130)
Query Neighborhood Hits	259	Target Neighborhood Hits	382	Shared Neighborhood Hits	147
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ARHG6_HUMAN
NC score	0.293335 (rank : 65)	θ value	0.163984 (rank : 91)
Query Neighborhood Hits	259	Target Neighborhood Hits	376	Shared Neighborhood Hits	145
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

IASPP_MOUSE
NC score	0.292560 (rank : 66)	θ value	2.44474e-05 (rank : 12)
Query Neighborhood Hits	259	Target Neighborhood Hits	1024	Shared Neighborhood Hits	162
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PACN1_MOUSE
NC score	0.288515 (rank : 67)	θ value	1.06291 (rank : 152)
Query Neighborhood Hits	259	Target Neighborhood Hits	283	Shared Neighborhood Hits	138
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

VAV_HUMAN
NC score	0.288047 (rank : 68)	θ value	0.00175202 (rank : 36)
Query Neighborhood Hits	259	Target Neighborhood Hits	452	Shared Neighborhood Hits	147
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.286321 (rank : 69)	θ value	0.00228821 (rank : 40)
Query Neighborhood Hits	259	Target Neighborhood Hits	430	Shared Neighborhood Hits	146
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PACN1_HUMAN
NC score	0.285787 (rank : 70)	θ value	1.06291 (rank : 151)
Query Neighborhood Hits	259	Target Neighborhood Hits	320	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

OSTF1_HUMAN
NC score	0.283871 (rank : 71)	θ value	0.00665767 (rank : 47)
Query Neighborhood Hits	259	Target Neighborhood Hits	466	Shared Neighborhood Hits	148
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.283703 (rank : 72)	θ value	0.00509761 (rank : 44)
Query Neighborhood Hits	259	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

STAM2_HUMAN
NC score	0.282151 (rank : 73)	θ value	1.38821 (rank : 168)
Query Neighborhood Hits	259	Target Neighborhood Hits	288	Shared Neighborhood Hits	145
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PACN3_MOUSE
NC score	0.278656 (rank : 74)	θ value	0.813845 (rank : 143)
Query Neighborhood Hits	259	Target Neighborhood Hits	380	Shared Neighborhood Hits	137
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.277284 (rank : 75)	θ value	0.813845 (rank : 142)
Query Neighborhood Hits	259	Target Neighborhood Hits	385	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NPHP1_HUMAN
NC score	0.272159 (rank : 76)	θ value	0.0961366 (rank : 84)
Query Neighborhood Hits	259	Target Neighborhood Hits	288	Shared Neighborhood Hits	128
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ITSN2_HUMAN
NC score	0.271003 (rank : 77)	θ value	0.00035302 (rank : 23)
Query Neighborhood Hits	259	Target Neighborhood Hits	1173	Shared Neighborhood Hits	169
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_MOUSE
NC score	0.266170 (rank : 78)	θ value	4.92598e-06 (rank : 9)
Query Neighborhood Hits	259	Target Neighborhood Hits	1669	Shared Neighborhood Hits	179
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.264331 (rank : 79)	θ value	2.21117e-06 (rank : 8)
Query Neighborhood Hits	259	Target Neighborhood Hits	1757	Shared Neighborhood Hits	185
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

RUSC1_HUMAN
NC score	0.264030 (rank : 80)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	259	Target Neighborhood Hits	226	Shared Neighborhood Hits	118
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

AHI1_HUMAN
NC score	0.260049 (rank : 81)	θ value	0.163984 (rank : 90)
Query Neighborhood Hits	259	Target Neighborhood Hits	537	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ASPP1_HUMAN
NC score	0.258330 (rank : 82)	θ value	0.000461057 (rank : 25)
Query Neighborhood Hits	259	Target Neighborhood Hits	956	Shared Neighborhood Hits	155
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NOXO1_MOUSE
NC score	0.256606 (rank : 83)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	259	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ITSN2_MOUSE
NC score	0.256570 (rank : 84)	θ value	0.000461057 (rank : 26)
Query Neighborhood Hits	259	Target Neighborhood Hits	1371	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DBNL_HUMAN
NC score	0.256422 (rank : 85)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	259	Target Neighborhood Hits	244	Shared Neighborhood Hits	127
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.253527 (rank : 86)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	259	Target Neighborhood Hits	306	Shared Neighborhood Hits	132
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ARHG9_HUMAN
NC score	0.253291 (rank : 87)	θ value	0.0252991 (rank : 65)
Query Neighborhood Hits	259	Target Neighborhood Hits	235	Shared Neighborhood Hits	128
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

AHI1_MOUSE
NC score	0.252645 (rank : 88)	θ value	0.0961366 (rank : 83)
Query Neighborhood Hits	259	Target Neighborhood Hits	496	Shared Neighborhood Hits	149
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ASPP1_MOUSE
NC score	0.251183 (rank : 89)	θ value	0.00175202 (rank : 34)
Query Neighborhood Hits	259	Target Neighborhood Hits	1244	Shared Neighborhood Hits	175
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ARHG9_MOUSE
NC score	0.250703 (rank : 90)	θ value	0.0563607 (rank : 74)
Query Neighborhood Hits	259	Target Neighborhood Hits	234	Shared Neighborhood Hits	129
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SNX18_MOUSE
NC score	0.241165 (rank : 91)	θ value	1.38821 (rank : 166)
Query Neighborhood Hits	259	Target Neighborhood Hits	198	Shared Neighborhood Hits	113
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

NEBL_HUMAN
NC score	0.234025 (rank : 92)	θ value	3.0926 (rank : 194)
Query Neighborhood Hits	259	Target Neighborhood Hits	457	Shared Neighborhood Hits	134
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ARHG4_HUMAN
NC score	0.233067 (rank : 93)	θ value	0.21417 (rank : 98)
Query Neighborhood Hits	259	Target Neighborhood Hits	242	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

VAV2_HUMAN
NC score	0.233027 (rank : 94)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	259	Target Neighborhood Hits	453	Shared Neighborhood Hits	143
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.232808 (rank : 95)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	259	Target Neighborhood Hits	456	Shared Neighborhood Hits	144
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

RUSC1_MOUSE
NC score	0.232590 (rank : 96)	θ value	0.813845 (rank : 144)
Query Neighborhood Hits	259	Target Neighborhood Hits	206	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ABI3_MOUSE
NC score	0.228534 (rank : 97)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.227090 (rank : 98)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC3_MOUSE
NC score	0.227078 (rank : 99)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	259	Target Neighborhood Hits	232	Shared Neighborhood Hits	121
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.226852 (rank : 100)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	120
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SNX18_HUMAN
NC score	0.226170 (rank : 101)	θ value	2.36792 (rank : 185)
Query Neighborhood Hits	259	Target Neighborhood Hits	207	Shared Neighborhood Hits	113
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV3_HUMAN
NC score	0.220962 (rank : 102)	θ value	2.36792 (rank : 186)
Query Neighborhood Hits	259	Target Neighborhood Hits	398	Shared Neighborhood Hits	143
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

LASP1_HUMAN
NC score	0.217749 (rank : 103)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	121
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.215135 (rank : 104)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	259	Target Neighborhood Hits	297	Shared Neighborhood Hits	120
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

VAV3_MOUSE
NC score	0.214422 (rank : 105)	θ value	4.03905 (rank : 211)
Query Neighborhood Hits	259	Target Neighborhood Hits	404	Shared Neighborhood Hits	142
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ASPP2_HUMAN
NC score	0.211879 (rank : 106)	θ value	0.00869519 (rank : 50)
Query Neighborhood Hits	259	Target Neighborhood Hits	1156	Shared Neighborhood Hits	147
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

RIMB2_HUMAN
NC score	0.211233 (rank : 107)	θ value	4.03905 (rank : 209)
Query Neighborhood Hits	259	Target Neighborhood Hits	263	Shared Neighborhood Hits	111
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RHG04_HUMAN
NC score	0.206921 (rank : 108)	θ value	0.0113563 (rank : 54)
Query Neighborhood Hits	259	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NEBU_HUMAN
NC score	0.204171 (rank : 109)	θ value	0.813845 (rank : 140)
Query Neighborhood Hits	259	Target Neighborhood Hits	420	Shared Neighborhood Hits	137
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

RIMB2_MOUSE
NC score	0.203240 (rank : 110)	θ value	5.27518 (rank : 224)
Query Neighborhood Hits	259	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L3_MOUSE
NC score	0.197860 (rank : 111)	θ value	0.62314 (rank : 123)
Query Neighborhood Hits	259	Target Neighborhood Hits	168	Shared Neighborhood Hits	110
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NOXO1_HUMAN
NC score	0.193858 (rank : 112)	θ value	4.03905 (rank : 207)
Query Neighborhood Hits	259	Target Neighborhood Hits	100	Shared Neighborhood Hits	78
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

PLCG1_MOUSE
NC score	0.192940 (rank : 113)	θ value	0.62314 (rank : 131)
Query Neighborhood Hits	259	Target Neighborhood Hits	314	Shared Neighborhood Hits	125
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_HUMAN
NC score	0.184777 (rank : 114)	θ value	1.06291 (rank : 153)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MYO1F_HUMAN
NC score	0.180536 (rank : 115)	θ value	0.000270298 (rank : 20)
Query Neighborhood Hits	259	Target Neighborhood Hits	275	Shared Neighborhood Hits	142
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.180114 (rank : 116)	θ value	0.000270298 (rank : 21)
Query Neighborhood Hits	259	Target Neighborhood Hits	262	Shared Neighborhood Hits	141
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

ARHG4_MOUSE
NC score	0.177529 (rank : 117)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SPTA2_HUMAN
NC score	0.174256 (rank : 118)	θ value	0.000602161 (rank : 32)
Query Neighborhood Hits	259	Target Neighborhood Hits	888	Shared Neighborhood Hits	150
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

PLCG2_HUMAN
NC score	0.171381 (rank : 119)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	259	Target Neighborhood Hits	280	Shared Neighborhood Hits	125
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ES8L2_HUMAN
NC score	0.166627 (rank : 120)	θ value	1.38821 (rank : 159)
Query Neighborhood Hits	259	Target Neighborhood Hits	193	Shared Neighborhood Hits	102
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

EPS8_MOUSE
NC score	0.164751 (rank : 121)	θ value	0.813845 (rank : 137)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

MYO1E_HUMAN
NC score	0.164065 (rank : 122)	θ value	0.0193708 (rank : 63)
Query Neighborhood Hits	259	Target Neighborhood Hits	293	Shared Neighborhood Hits	137
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

EPS8_HUMAN
NC score	0.158162 (rank : 123)	θ value	3.0926 (rank : 191)
Query Neighborhood Hits	259	Target Neighborhood Hits	151	Shared Neighborhood Hits	92
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

RHG26_HUMAN
NC score	0.157950 (rank : 124)	θ value	1.81305 (rank : 179)
Query Neighborhood Hits	259	Target Neighborhood Hits	281	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SNX9_HUMAN
NC score	0.156684 (rank : 125)	θ value	1.06291 (rank : 155)
Query Neighborhood Hits	259	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

ES8L2_MOUSE
NC score	0.155291 (rank : 126)	θ value	0.813845 (rank : 138)
Query Neighborhood Hits	259	Target Neighborhood Hits	169	Shared Neighborhood Hits	96
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SPTA1_HUMAN
NC score	0.151184 (rank : 127)	θ value	0.163984 (rank : 94)
Query Neighborhood Hits	259	Target Neighborhood Hits	748	Shared Neighborhood Hits	142
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_MOUSE
NC score	0.149013 (rank : 128)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	259	Target Neighborhood Hits	324	Shared Neighborhood Hits	125
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SHLB1_MOUSE
NC score	0.146176 (rank : 129)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SNX9_MOUSE
NC score	0.146056 (rank : 130)	θ value	0.365318 (rank : 112)
Query Neighborhood Hits	259	Target Neighborhood Hits	141	Shared Neighborhood Hits	75
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SRGP2_HUMAN
NC score	0.144479 (rank : 131)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	259	Target Neighborhood Hits	331	Shared Neighborhood Hits	124
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SHLB1_HUMAN
NC score	0.143822 (rank : 132)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	259	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

TCGAP_HUMAN
NC score	0.143547 (rank : 133)	θ value	6.88961 (rank : 242)
Query Neighborhood Hits	259	Target Neighborhood Hits	872	Shared Neighborhood Hits	139
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRGP1_HUMAN
NC score	0.143041 (rank : 134)	θ value	0.279714 (rank : 106)
Query Neighborhood Hits	259	Target Neighborhood Hits	390	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TCGAP_MOUSE
NC score	0.142848 (rank : 135)	θ value	4.03905 (rank : 210)
Query Neighborhood Hits	259	Target Neighborhood Hits	409	Shared Neighborhood Hits	118
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RIMB1_HUMAN
NC score	0.142061 (rank : 136)	θ value	0.0961366 (rank : 86)
Query Neighborhood Hits	259	Target Neighborhood Hits	1479	Shared Neighborhood Hits	148
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPTA1_MOUSE
NC score	0.142046 (rank : 137)	θ value	1.38821 (rank : 167)
Query Neighborhood Hits	259	Target Neighborhood Hits	675	Shared Neighborhood Hits	138
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DDEF1_MOUSE
NC score	0.140910 (rank : 138)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	259	Target Neighborhood Hits	592	Shared Neighborhood Hits	135
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ANM2_HUMAN
NC score	0.139306 (rank : 139)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	259	Target Neighborhood Hits	175	Shared Neighborhood Hits	115
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

DDEF2_MOUSE
NC score	0.139185 (rank : 140)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	259	Target Neighborhood Hits	625	Shared Neighborhood Hits	130
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.138193 (rank : 141)	θ value	3.0926 (rank : 190)
Query Neighborhood Hits	259	Target Neighborhood Hits	599	Shared Neighborhood Hits	132
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ES8L3_HUMAN
NC score	0.138000 (rank : 142)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	259	Target Neighborhood Hits	206	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ANM2_MOUSE
NC score	0.133185 (rank : 143)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	259	Target Neighborhood Hits	175	Shared Neighborhood Hits	111
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FNBP2_HUMAN
NC score	0.132337 (rank : 144)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	259	Target Neighborhood Hits	432	Shared Neighborhood Hits	124
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RIMB1_MOUSE
NC score	0.129130 (rank : 145)	θ value	0.21417 (rank : 101)
Query Neighborhood Hits	259	Target Neighborhood Hits	1376	Shared Neighborhood Hits	166
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

M3KL4_HUMAN
NC score	0.121126 (rank : 146)	θ value	0.00175202 (rank : 35)
Query Neighborhood Hits	259	Target Neighborhood Hits	1087	Shared Neighborhood Hits	149
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

ES8L1_HUMAN
NC score	0.118825 (rank : 147)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	259	Target Neighborhood Hits	162	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SHLB2_MOUSE
NC score	0.118301 (rank : 148)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	259	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.117277 (rank : 149)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	259	Target Neighborhood Hits	86	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ES8L1_MOUSE
NC score	0.116025 (rank : 150)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	259	Target Neighborhood Hits	143	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

M3K11_HUMAN
NC score	0.115133 (rank : 151)	θ value	1.87187e-05 (rank : 11)
Query Neighborhood Hits	259	Target Neighborhood Hits	1136	Shared Neighborhood Hits	159
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MCF2L_MOUSE
NC score	0.112144 (rank : 152)	θ value	4.03905 (rank : 205)
Query Neighborhood Hits	259	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

CIKS_HUMAN
NC score	0.111155 (rank : 153)	θ value	0.0148317 (rank : 56)
Query Neighborhood Hits	259	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

RUSC2_HUMAN
NC score	0.108599 (rank : 154)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SHAN2_MOUSE
NC score	0.106108 (rank : 155)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	259	Target Neighborhood Hits	446	Shared Neighborhood Hits	100
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

M3K9_HUMAN
NC score	0.102358 (rank : 156)	θ value	0.0330416 (rank : 70)
Query Neighborhood Hits	259	Target Neighborhood Hits	1123	Shared Neighborhood Hits	146
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ARHG5_HUMAN
NC score	0.102052 (rank : 157)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	259	Target Neighborhood Hits	172	Shared Neighborhood Hits	71
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SPN90_HUMAN
NC score	0.101487 (rank : 158)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NGEF_MOUSE
NC score	0.098532 (rank : 159)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

GAB1_MOUSE
NC score	0.096138 (rank : 160)	θ value	0.00228821 (rank : 38)
Query Neighborhood Hits	259	Target Neighborhood Hits	233	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

NGEF_HUMAN
NC score	0.094843 (rank : 161)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	259	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SHAN1_HUMAN
NC score	0.094238 (rank : 162)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	259	Target Neighborhood Hits	1041	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GAB1_HUMAN
NC score	0.093287 (rank : 163)	θ value	0.0148317 (rank : 58)
Query Neighborhood Hits	259	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

M3K10_HUMAN
NC score	0.091888 (rank : 164)	θ value	0.0330416 (rank : 69)
Query Neighborhood Hits	259	Target Neighborhood Hits	1071	Shared Neighborhood Hits	138
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

STS2_HUMAN
NC score	0.089748 (rank : 165)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	69
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RUSC2_MOUSE
NC score	0.088498 (rank : 166)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	259	Target Neighborhood Hits	305	Shared Neighborhood Hits	72
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

PKHG1_HUMAN
NC score	0.086771 (rank : 167)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	259	Target Neighborhood Hits	174	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

YES_MOUSE
NC score	0.085489 (rank : 168)	θ value	0.813845 (rank : 146)
Query Neighborhood Hits	259	Target Neighborhood Hits	1052	Shared Neighborhood Hits	146
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_HUMAN
NC score	0.085315 (rank : 169)	θ value	0.62314 (rank : 133)
Query Neighborhood Hits	259	Target Neighborhood Hits	1058	Shared Neighborhood Hits	151
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SF3A2_HUMAN
NC score	0.085240 (rank : 170)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	259	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

YES_HUMAN
NC score	0.084834 (rank : 171)	θ value	0.813845 (rank : 145)
Query Neighborhood Hits	259	Target Neighborhood Hits	1059	Shared Neighborhood Hits	144
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SPN90_MOUSE
NC score	0.084201 (rank : 172)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	259	Target Neighborhood Hits	157	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

BTK_HUMAN
NC score	0.083880 (rank : 173)	θ value	0.0736092 (rank : 77)
Query Neighborhood Hits	259	Target Neighborhood Hits	1026	Shared Neighborhood Hits	146
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FYN_MOUSE
NC score	0.083394 (rank : 174)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	259	Target Neighborhood Hits	1073	Shared Neighborhood Hits	146
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

PREX1_HUMAN
NC score	0.083019 (rank : 175)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	259	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SF3A2_MOUSE
NC score	0.082934 (rank : 176)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	259	Target Neighborhood Hits	247	Shared Neighborhood Hits	20
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

ARHGG_MOUSE
NC score	0.082722 (rank : 177)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	259	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG3_HUMAN
NC score	0.082275 (rank : 178)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	259	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.082153 (rank : 179)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

FYN_HUMAN
NC score	0.082004 (rank : 180)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	259	Target Neighborhood Hits	1078	Shared Neighborhood Hits	146
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_HUMAN
NC score	0.081933 (rank : 181)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	259	Target Neighborhood Hits	1067	Shared Neighborhood Hits	142
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TIAM1_MOUSE
NC score	0.081288 (rank : 182)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	25
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.080146 (rank : 183)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_MOUSE
NC score	0.079695 (rank : 184)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	259	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

HCK_HUMAN
NC score	0.078887 (rank : 185)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	259	Target Neighborhood Hits	1035	Shared Neighborhood Hits	140
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FGR_MOUSE
NC score	0.078405 (rank : 186)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	259	Target Neighborhood Hits	1069	Shared Neighborhood Hits	143
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SLY_MOUSE
NC score	0.077886 (rank : 187)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

P85A_MOUSE
NC score	0.077817 (rank : 188)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	259	Target Neighborhood Hits	435	Shared Neighborhood Hits	91
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TAB3_MOUSE
NC score	0.077372 (rank : 189)	θ value	0.21417 (rank : 102)
Query Neighborhood Hits	259	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

AMPH_HUMAN
NC score	0.076792 (rank : 190)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	259	Target Neighborhood Hits	455	Shared Neighborhood Hits	81
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

BTK_MOUSE
NC score	0.076536 (rank : 191)	θ value	0.279714 (rank : 103)
Query Neighborhood Hits	259	Target Neighborhood Hits	1017	Shared Neighborhood Hits	138
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ARHG8_HUMAN
NC score	0.076133 (rank : 192)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

CIP4_HUMAN
NC score	0.075131 (rank : 193)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	259	Target Neighborhood Hits	374	Shared Neighborhood Hits	68
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

DOCK1_HUMAN
NC score	0.073908 (rank : 194)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	259	Target Neighborhood Hits	191	Shared Neighborhood Hits	95
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

HCK_MOUSE
NC score	0.073597 (rank : 195)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	259	Target Neighborhood Hits	1029	Shared Neighborhood Hits	139
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

P85A_HUMAN
NC score	0.073562 (rank : 196)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	259	Target Neighborhood Hits	479	Shared Neighborhood Hits	86
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PRP2_MOUSE
NC score	0.073524 (rank : 197)	θ value	1.06291 (rank : 154)
Query Neighborhood Hits	259	Target Neighborhood Hits	347	Shared Neighborhood Hits	25
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SLAP2_HUMAN
NC score	0.072830 (rank : 198)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	259	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

MCF2_HUMAN
NC score	0.072814 (rank : 199)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	259	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGG_HUMAN
NC score	0.072435 (rank : 200)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	259	Target Neighborhood Hits	129	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AMPH_MOUSE
NC score	0.072307 (rank : 201)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	259	Target Neighborhood Hits	291	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

FRK_HUMAN
NC score	0.071888 (rank : 202)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	259	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SRC_MOUSE
NC score	0.071776 (rank : 203)	θ value	5.27518 (rank : 226)
Query Neighborhood Hits	259	Target Neighborhood Hits	1033	Shared Neighborhood Hits	132
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

RGS3_MOUSE
NC score	0.071122 (rank : 204)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	259	Target Neighborhood Hits	1621	Shared Neighborhood Hits	93
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SLAP2_MOUSE
NC score	0.070822 (rank : 205)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	259	Target Neighborhood Hits	136	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ARHGA_MOUSE
NC score	0.070652 (rank : 206)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	259	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ATN1_HUMAN
NC score	0.069295 (rank : 207)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	259	Target Neighborhood Hits	676	Shared Neighborhood Hits	46
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

TAB3_HUMAN
NC score	0.068586 (rank : 208)	θ value	0.0736092 (rank : 82)
Query Neighborhood Hits	259	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

STS1_HUMAN
NC score	0.068009 (rank : 209)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	259	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.067966 (rank : 210)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	259	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SLY_HUMAN
NC score	0.067686 (rank : 211)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	259	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

LYN_HUMAN
NC score	0.066963 (rank : 212)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	259	Target Neighborhood Hits	1022	Shared Neighborhood Hits	128
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ARHGA_HUMAN
NC score	0.066824 (rank : 213)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	259	Target Neighborhood Hits	187	Shared Neighborhood Hits	23
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

LYN_MOUSE
NC score	0.066168 (rank : 214)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	259	Target Neighborhood Hits	1023	Shared Neighborhood Hits	129
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BIN1_HUMAN
NC score	0.066152 (rank : 215)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	259	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SPT5H_HUMAN
NC score	0.065108 (rank : 216)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	259	Target Neighborhood Hits	436	Shared Neighborhood Hits	39
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

P85B_HUMAN
NC score	0.064972 (rank : 217)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	259	Target Neighborhood Hits	543	Shared Neighborhood Hits	69
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SPT5H_MOUSE
NC score	0.064435 (rank : 218)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	259	Target Neighborhood Hits	437	Shared Neighborhood Hits	39
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

BIN1_MOUSE
NC score	0.063324 (rank : 219)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	259	Target Neighborhood Hits	283	Shared Neighborhood Hits	67
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

ECT2_MOUSE
NC score	0.062778 (rank : 220)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	259	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RAPH1_HUMAN
NC score	0.061968 (rank : 221)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	259	Target Neighborhood Hits	593	Shared Neighborhood Hits	47
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

EM55_HUMAN
NC score	0.061833 (rank : 222)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	259	Target Neighborhood Hits	228	Shared Neighborhood Hits	83
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

BLK_HUMAN
NC score	0.061783 (rank : 223)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	259	Target Neighborhood Hits	994	Shared Neighborhood Hits	113
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

WASIP_HUMAN
NC score	0.061322 (rank : 224)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	259	Target Neighborhood Hits	458	Shared Neighborhood Hits	33
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

PPIP2_HUMAN
NC score	0.061303 (rank : 225)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	259	Target Neighborhood Hits	254	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PTK6_HUMAN
NC score	0.061241 (rank : 226)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	259	Target Neighborhood Hits	1020	Shared Neighborhood Hits	130
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

WASIP_MOUSE
NC score	0.061195 (rank : 227)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	259	Target Neighborhood Hits	392	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

SLAP1_HUMAN
NC score	0.061072 (rank : 228)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	259	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BI2L1_HUMAN
NC score	0.061060 (rank : 229)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	259	Target Neighborhood Hits	156	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PTK6_MOUSE
NC score	0.061000 (rank : 230)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	259	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ARHG1_HUMAN
NC score	0.060944 (rank : 231)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	259	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

RERE_MOUSE
NC score	0.060730 (rank : 232)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	259	Target Neighborhood Hits	785	Shared Neighborhood Hits	40
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RASA1_HUMAN
NC score	0.060408 (rank : 233)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	259	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ECT2_HUMAN
NC score	0.060405 (rank : 234)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	259	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARI1B_HUMAN
NC score	0.060288 (rank : 235)	θ value	0.163984 (rank : 93)
Query Neighborhood Hits	259	Target Neighborhood Hits	567	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

SYN1_MOUSE
NC score	0.060091 (rank : 236)	θ value	0.163984 (rank : 95)
Query Neighborhood Hits	259	Target Neighborhood Hits	363	Shared Neighborhood Hits	26
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

P85B_MOUSE
NC score	0.059970 (rank : 237)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	259	Target Neighborhood Hits	519	Shared Neighborhood Hits	64
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SON_HUMAN
NC score	0.059688 (rank : 238)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	259	Target Neighborhood Hits	1568	Shared Neighborhood Hits	76
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SLAP1_MOUSE
NC score	0.059662 (rank : 239)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	259	Target Neighborhood Hits	117	Shared Neighborhood Hits	30
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

CSK_HUMAN
NC score	0.059302 (rank : 240)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	259	Target Neighborhood Hits	1009	Shared Neighborhood Hits	117
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.059241 (rank : 241)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	259	Target Neighborhood Hits	1009	Shared Neighborhood Hits	117
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

HAPIP_HUMAN
NC score	0.059161 (rank : 242)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	259	Target Neighborhood Hits	350	Shared Neighborhood Hits	32
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NACAM_MOUSE
NC score	0.059147 (rank : 243)	θ value	5.27518 (rank : 221)
Query Neighborhood Hits	259	Target Neighborhood Hits	1866	Shared Neighborhood Hits	95
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

EM55_MOUSE
NC score	0.059044 (rank : 244)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	259	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ARI1A_HUMAN
NC score	0.058989 (rank : 245)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	259	Target Neighborhood Hits	787	Shared Neighborhood Hits	53
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

PPIP2_MOUSE
NC score	0.058701 (rank : 246)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	259	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

TXK_MOUSE
NC score	0.058529 (rank : 247)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	259	Target Neighborhood Hits	980	Shared Neighborhood Hits	113
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

PRRT3_HUMAN
NC score	0.058052 (rank : 248)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	259	Target Neighborhood Hits	998	Shared Neighborhood Hits	63
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

FGD1_HUMAN
NC score	0.057948 (rank : 249)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	259	Target Neighborhood Hits	367	Shared Neighborhood Hits	39
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHGB_HUMAN
NC score	0.057866 (rank : 250)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	259	Target Neighborhood Hits	375	Shared Neighborhood Hits	31
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GSCR1_HUMAN
NC score	0.057749 (rank : 251)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	259	Target Neighborhood Hits	674	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

ARHGC_HUMAN
NC score	0.057382 (rank : 252)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	259	Target Neighborhood Hits	351	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.057110 (rank : 253)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	259	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RGNEF_MOUSE
NC score	0.056957 (rank : 254)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	259	Target Neighborhood Hits	641	Shared Neighborhood Hits	51
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

DAPP1_MOUSE
NC score	0.056621 (rank : 255)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	259	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GGN_MOUSE
NC score	0.056566 (rank : 256)	θ value	0.21417 (rank : 99)
Query Neighborhood Hits	259	Target Neighborhood Hits	311	Shared Neighborhood Hits	21
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

BLK_MOUSE
NC score	0.056153 (rank : 257)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	259	Target Neighborhood Hits	992	Shared Neighborhood Hits	105
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

OGFR_HUMAN
NC score	0.055845 (rank : 258)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	259	Target Neighborhood Hits	1582	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ARHGF_HUMAN
NC score	0.055824 (rank : 259)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	259	Target Neighborhood Hits	214	Shared Neighborhood Hits	31
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

DAPP1_HUMAN
NC score	0.055706 (rank : 260)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	259	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SYN1_HUMAN
NC score	0.055681 (rank : 261)	θ value	0.62314 (rank : 134)
Query Neighborhood Hits	259	Target Neighborhood Hits	419	Shared Neighborhood Hits	25
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

MBD6_HUMAN
NC score	0.055663 (rank : 262)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	259	Target Neighborhood Hits	349	Shared Neighborhood Hits	22
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MUC1_HUMAN
NC score	0.055167 (rank : 263)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	259	Target Neighborhood Hits	975	Shared Neighborhood Hits	60
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

BAT2_HUMAN
NC score	0.054923 (rank : 264)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	259	Target Neighborhood Hits	931	Shared Neighborhood Hits	56
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

LCP2_HUMAN
NC score	0.054458 (rank : 265)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	259	Target Neighborhood Hits	531	Shared Neighborhood Hits	62
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MPP5_HUMAN
NC score	0.054455 (rank : 266)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	259	Target Neighborhood Hits	231	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

LBC_HUMAN
NC score	0.054143 (rank : 267)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	259	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MPP5_MOUSE
NC score	0.054096 (rank : 268)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	259	Target Neighborhood Hits	226	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

TEC_HUMAN
NC score	0.054029 (rank : 269)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	259	Target Neighborhood Hits	1006	Shared Neighborhood Hits	116
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ABL1_MOUSE
NC score	0.053924 (rank : 270)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	259	Target Neighborhood Hits	1178	Shared Neighborhood Hits	117
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

LCK_HUMAN
NC score	0.053757 (rank : 271)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	259	Target Neighborhood Hits	987	Shared Neighborhood Hits	95
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SPTA3_MOUSE
NC score	0.053749 (rank : 272)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	259	Target Neighborhood Hits	74	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

RERE_HUMAN
NC score	0.053445 (rank : 273)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	259	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

LCK_MOUSE
NC score	0.053414 (rank : 274)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	259	Target Neighborhood Hits	981	Shared Neighborhood Hits	94
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SHC1_HUMAN
NC score	0.053325 (rank : 275)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	259	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

ABL1_HUMAN
NC score	0.053234 (rank : 276)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	259	Target Neighborhood Hits	1220	Shared Neighborhood Hits	112
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TXK_HUMAN
NC score	0.053202 (rank : 277)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	259	Target Neighborhood Hits	971	Shared Neighborhood Hits	105
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

MPP6_HUMAN
NC score	0.052874 (rank : 278)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	259	Target Neighborhood Hits	180	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

BAIP2_MOUSE
NC score	0.052860 (rank : 279)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

TEC_MOUSE
NC score	0.052698 (rank : 280)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	259	Target Neighborhood Hits	1006	Shared Neighborhood Hits	116
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ITK_HUMAN
NC score	0.052085 (rank : 281)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	259	Target Neighborhood Hits	1016	Shared Neighborhood Hits	111
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ARHG2_HUMAN
NC score	0.052066 (rank : 282)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	259	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG1_MOUSE
NC score	0.052063 (rank : 283)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	259	Target Neighborhood Hits	266	Shared Neighborhood Hits	26
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FGD3_MOUSE
NC score	0.051797 (rank : 284)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	259	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

DLG5_HUMAN
NC score	0.051649 (rank : 285)	θ value	0.47712 (rank : 116)
Query Neighborhood Hits	259	Target Neighborhood Hits	1088	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

APS_HUMAN
NC score	0.051452 (rank : 286)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	259	Target Neighborhood Hits	162	Shared Neighborhood Hits	37
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG2_MOUSE
NC score	0.051434 (rank : 287)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	259	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGS3_HUMAN
NC score	0.051428 (rank : 288)	θ value	3.0926 (rank : 195)
Query Neighborhood Hits	259	Target Neighborhood Hits	1375	Shared Neighborhood Hits	78
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SHE_MOUSE
NC score	0.051389 (rank : 289)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	259	Target Neighborhood Hits	169	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

EP15_MOUSE
NC score	0.050997 (rank : 290)	θ value	1.81305 (rank : 174)
Query Neighborhood Hits	259	Target Neighborhood Hits	820	Shared Neighborhood Hits	34
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

SH21B_MOUSE
NC score	0.050759 (rank : 291)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PHC2_HUMAN
NC score	0.050714 (rank : 292)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	259	Target Neighborhood Hits	388	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

BAIP2_HUMAN
NC score	0.050644 (rank : 293)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	259	Target Neighborhood Hits	192	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SH21B_HUMAN
NC score	0.050601 (rank : 294)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GNRP_MOUSE
NC score	0.050507 (rank : 295)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	259	Target Neighborhood Hits	191	Shared Neighborhood Hits	21
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD3_HUMAN
NC score	0.050459 (rank : 296)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	259	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

MEPE_HUMAN
NC score	0.050342 (rank : 297)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	259	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

CSKI1_HUMAN
NC score	0.050277 (rank : 298)	θ value	1.38821 (rank : 158)
Query Neighborhood Hits	259	Target Neighborhood Hits	997	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

TXND2_HUMAN
NC score	0.050276 (rank : 299)	θ value	1.06291 (rank : 156)
Query Neighborhood Hits	259	Target Neighborhood Hits	793	Shared Neighborhood Hits	47
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

MPP6_MOUSE
NC score	0.050213 (rank : 300)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	259	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

P55G_MOUSE
NC score	0.050162 (rank : 301)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	259	Target Neighborhood Hits	401	Shared Neighborhood Hits	47
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
NC score	0.050129 (rank : 302)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	259	Target Neighborhood Hits	451	Shared Neighborhood Hits	49
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MUC7_HUMAN
NC score	0.050082 (rank : 303)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	259	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SRMS_MOUSE
NC score	0.049454 (rank : 304)	θ value	6.88961 (rank : 240)
Query Neighborhood Hits	259	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MINT_MOUSE
NC score	0.049247 (rank : 305)	θ value	4.03905 (rank : 206)
Query Neighborhood Hits	259	Target Neighborhood Hits	1514	Shared Neighborhood Hits	80
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MLL2_HUMAN
NC score	0.047834 (rank : 306)	θ value	1.81305 (rank : 175)
Query Neighborhood Hits	259	Target Neighborhood Hits	1788	Shared Neighborhood Hits	71
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

CSKI1_MOUSE
NC score	0.047622 (rank : 307)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	259	Target Neighborhood Hits	1031	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MATK_HUMAN
NC score	0.047303 (rank : 308)	θ value	0.0563607 (rank : 76)
Query Neighborhood Hits	259	Target Neighborhood Hits	954	Shared Neighborhood Hits	66
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MINT_HUMAN
NC score	0.046042 (rank : 309)	θ value	1.06291 (rank : 150)
Query Neighborhood Hits	259	Target Neighborhood Hits	1291	Shared Neighborhood Hits	67
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MATK_MOUSE
NC score	0.045915 (rank : 310)	θ value	1.06291 (rank : 149)
Query Neighborhood Hits	259	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

YLPM1_MOUSE
NC score	0.045827 (rank : 311)	θ value	3.0926 (rank : 199)
Query Neighborhood Hits	259	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

EWS_MOUSE
NC score	0.045628 (rank : 312)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	259	Target Neighborhood Hits	271	Shared Neighborhood Hits	16
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

BRD4_HUMAN
NC score	0.044926 (rank : 313)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	259	Target Neighborhood Hits	851	Shared Neighborhood Hits	51
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

SRMS_HUMAN
NC score	0.044563 (rank : 314)	θ value	0.365318 (rank : 113)
Query Neighborhood Hits	259	Target Neighborhood Hits	946	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

S3TC1_HUMAN
NC score	0.043935 (rank : 315)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	259	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

EWS_HUMAN
NC score	0.043410 (rank : 316)	θ value	0.62314 (rank : 124)
Query Neighborhood Hits	259	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

BRD4_MOUSE
NC score	0.043224 (rank : 317)	θ value	2.36792 (rank : 182)
Query Neighborhood Hits	259	Target Neighborhood Hits	845	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

FMN2_HUMAN
NC score	0.041281 (rank : 318)	θ value	1.06291 (rank : 148)
Query Neighborhood Hits	259	Target Neighborhood Hits	484	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

TRML1_MOUSE
NC score	0.040282 (rank : 319)	θ value	0.62314 (rank : 135)
Query Neighborhood Hits	259	Target Neighborhood Hits	44	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K558, Q9D3N6	Gene names	Treml1, Tlt1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

ALEX_MOUSE
NC score	0.037999 (rank : 320)	θ value	1.38821 (rank : 157)
Query Neighborhood Hits	259	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

G3BP_MOUSE
NC score	0.036443 (rank : 321)	θ value	0.365318 (rank : 110)
Query Neighborhood Hits	259	Target Neighborhood Hits	209	Shared Neighborhood Hits	12
SwissProt Accessions	P97855	Gene names	G3bp, G3bp1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

K1688_MOUSE
NC score	0.035695 (rank : 322)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	259	Target Neighborhood Hits	188	Shared Neighborhood Hits	19
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

CEL_HUMAN
NC score	0.035392 (rank : 323)	θ value	0.125558 (rank : 88)
Query Neighborhood Hits	259	Target Neighborhood Hits	896	Shared Neighborhood Hits	51
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

G3BP_HUMAN
NC score	0.034455 (rank : 324)	θ value	0.813845 (rank : 139)
Query Neighborhood Hits	259	Target Neighborhood Hits	219	Shared Neighborhood Hits	14
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

BSN_HUMAN
NC score	0.034173 (rank : 325)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	259	Target Neighborhood Hits	1537	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

TARA_HUMAN
NC score	0.032376 (rank : 326)	θ value	6.88961 (rank : 241)
Query Neighborhood Hits	259	Target Neighborhood Hits	1626	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MAP1A_HUMAN
NC score	0.031292 (rank : 327)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	259	Target Neighborhood Hits	1626	Shared Neighborhood Hits	72
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

TRDN_HUMAN
NC score	0.031171 (rank : 328)	θ value	3.0926 (rank : 198)
Query Neighborhood Hits	259	Target Neighborhood Hits	542	Shared Neighborhood Hits	20
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

RTN1_MOUSE
NC score	0.031060 (rank : 329)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	259	Target Neighborhood Hits	189	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

WNK2_HUMAN
NC score	0.030888 (rank : 330)	θ value	0.0148317 (rank : 60)
Query Neighborhood Hits	259	Target Neighborhood Hits	1407	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

AKAP2_MOUSE
NC score	0.030755 (rank : 331)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	259	Target Neighborhood Hits	385	Shared Neighborhood Hits	26
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

MED12_HUMAN
NC score	0.029006 (rank : 332)	θ value	3.0926 (rank : 193)
Query Neighborhood Hits	259	Target Neighborhood Hits	262	Shared Neighborhood Hits	15
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

DOK1_MOUSE
NC score	0.028198 (rank : 333)	θ value	5.27518 (rank : 217)
Query Neighborhood Hits	259	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

INCE_MOUSE
NC score	0.028176 (rank : 334)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	259	Target Neighborhood Hits	903	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

RTN4_MOUSE
NC score	0.026820 (rank : 335)	θ value	3.0926 (rank : 196)
Query Neighborhood Hits	259	Target Neighborhood Hits	341	Shared Neighborhood Hits	24
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

MAGD1_HUMAN
NC score	0.026578 (rank : 336)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	259	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

RABE1_HUMAN
NC score	0.026478 (rank : 337)	θ value	0.62314 (rank : 132)
Query Neighborhood Hits	259	Target Neighborhood Hits	1104	Shared Neighborhood Hits	45
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

FES_HUMAN
NC score	0.025457 (rank : 338)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	259	Target Neighborhood Hits	978	Shared Neighborhood Hits	42
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PGFRB_MOUSE
NC score	0.025265 (rank : 339)	θ value	1.38821 (rank : 163)
Query Neighborhood Hits	259	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

MAML1_MOUSE
NC score	0.024968 (rank : 340)	θ value	5.27518 (rank : 220)
Query Neighborhood Hits	259	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

TRHY_HUMAN
NC score	0.024448 (rank : 341)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	259	Target Neighborhood Hits	1385	Shared Neighborhood Hits	45
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

KTN1_MOUSE
NC score	0.024149 (rank : 342)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	259	Target Neighborhood Hits	1324	Shared Neighborhood Hits	52
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

TITIN_HUMAN
NC score	0.024143 (rank : 343)	θ value	0.0330416 (rank : 72)
Query Neighborhood Hits	259	Target Neighborhood Hits	2923	Shared Neighborhood Hits	85
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NEST_HUMAN
NC score	0.023607 (rank : 344)	θ value	1.81305 (rank : 177)
Query Neighborhood Hits	259	Target Neighborhood Hits	1305	Shared Neighborhood Hits	47
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

DAZL_MOUSE
NC score	0.023373 (rank : 345)	θ value	1.81305 (rank : 170)
Query Neighborhood Hits	259	Target Neighborhood Hits	152	Shared Neighborhood Hits	8
SwissProt Accessions	Q64368	Gene names	Dazl, Dazl1, Dazla
Domain Architecture
Description	Deleted in azoospermia-like (DAZ-like autosomal) (Deleted in azoospermia-like 1).

DAB1_HUMAN
NC score	0.023202 (rank : 346)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	259	Target Neighborhood Hits	219	Shared Neighborhood Hits	20
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

KTN1_HUMAN
NC score	0.022951 (rank : 347)	θ value	2.36792 (rank : 183)
Query Neighborhood Hits	259	Target Neighborhood Hits	1197	Shared Neighborhood Hits	42
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NCOR1_MOUSE
NC score	0.022753 (rank : 348)	θ value	2.36792 (rank : 184)
Query Neighborhood Hits	259	Target Neighborhood Hits	521	Shared Neighborhood Hits	28
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

CT2NL_HUMAN
NC score	0.022580 (rank : 349)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	259	Target Neighborhood Hits	1059	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MAGD1_MOUSE
NC score	0.022462 (rank : 350)	θ value	0.279714 (rank : 105)
Query Neighborhood Hits	259	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

BRD2_HUMAN
NC score	0.022299 (rank : 351)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	259	Target Neighborhood Hits	242	Shared Neighborhood Hits	19
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

CSTFT_MOUSE
NC score	0.022172 (rank : 352)	θ value	0.279714 (rank : 104)
Query Neighborhood Hits	259	Target Neighborhood Hits	356	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

NFIC_HUMAN
NC score	0.020307 (rank : 353)	θ value	0.365318 (rank : 111)
Query Neighborhood Hits	259	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P08651, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1	Gene names	NFIC, NFI
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

SMG7_MOUSE
NC score	0.019413 (rank : 354)	θ value	5.27518 (rank : 225)
Query Neighborhood Hits	259	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q5RJH6, Q63ZW5, Q6ZQF3	Gene names	Smg7, Est1c, Kiaa0250
Domain Architecture	No domain graphic available
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

DNMT1_MOUSE
NC score	0.018946 (rank : 355)	θ value	1.81305 (rank : 173)
Query Neighborhood Hits	259	Target Neighborhood Hits	137	Shared Neighborhood Hits	8
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

CO1A1_MOUSE
NC score	0.018477 (rank : 356)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	259	Target Neighborhood Hits	457	Shared Neighborhood Hits	22
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO1A1_HUMAN
NC score	0.017490 (rank : 357)	θ value	1.06291 (rank : 147)
Query Neighborhood Hits	259	Target Neighborhood Hits	475	Shared Neighborhood Hits	23
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

SLK_MOUSE
NC score	0.017215 (rank : 358)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	259	Target Neighborhood Hits	1798	Shared Neighborhood Hits	63
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

HMMR_MOUSE
NC score	0.016893 (rank : 359)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	259	Target Neighborhood Hits	1178	Shared Neighborhood Hits	43
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

NFAC2_HUMAN
NC score	0.016333 (rank : 360)	θ value	1.81305 (rank : 178)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	13
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

BRMS1_MOUSE
NC score	0.016059 (rank : 361)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	259	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q99N20	Gene names	Brms1
Domain Architecture	No domain graphic available
Description	Breast cancer metastasis-suppressor 1 homolog.

APC_MOUSE
NC score	0.016042 (rank : 362)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	259	Target Neighborhood Hits	441	Shared Neighborhood Hits	18
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

RBBP6_MOUSE
NC score	0.015268 (rank : 363)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	259	Target Neighborhood Hits	1014	Shared Neighborhood Hits	38
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RBBP6_HUMAN
NC score	0.014929 (rank : 364)	θ value	5.27518 (rank : 223)
Query Neighborhood Hits	259	Target Neighborhood Hits	1135	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SN1L2_HUMAN
NC score	0.014734 (rank : 365)	θ value	1.38821 (rank : 165)
Query Neighborhood Hits	259	Target Neighborhood Hits	964	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

ARNT2_MOUSE
NC score	0.014331 (rank : 366)	θ value	2.36792 (rank : 181)
Query Neighborhood Hits	259	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.013827 (rank : 367)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	259	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

PAX9_MOUSE
NC score	0.013166 (rank : 368)	θ value	4.03905 (rank : 208)
Query Neighborhood Hits	259	Target Neighborhood Hits	67	Shared Neighborhood Hits	6
SwissProt Accessions	P47242	Gene names	Pax9, Pax-9
Domain Architecture
Description	Paired box protein Pax-9.

CE110_HUMAN
NC score	0.012423 (rank : 369)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	259	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

MAK_MOUSE
NC score	0.012155 (rank : 370)	θ value	3.0926 (rank : 192)
Query Neighborhood Hits	259	Target Neighborhood Hits	873	Shared Neighborhood Hits	30
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

CHK1_HUMAN
NC score	0.011669 (rank : 371)	θ value	3.0926 (rank : 189)
Query Neighborhood Hits	259	Target Neighborhood Hits	843	Shared Neighborhood Hits	27
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

S18L1_HUMAN
NC score	0.010879 (rank : 372)	θ value	6.88961 (rank : 239)
Query Neighborhood Hits	259	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O75177, Q5JXJ3, Q8NE69, Q9BR55, Q9H4K6	Gene names	SS18L1, KIAA0693
Domain Architecture
Description	SS18-like protein 1 (SYT homolog 1).

SSX4_HUMAN
NC score	0.010128 (rank : 373)	θ value	3.0926 (rank : 197)
Query Neighborhood Hits	259	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	O60224, Q5JQZ0, Q9UJU9	Gene names	SSX4
Domain Architecture
Description	Protein SSX4.

PAX9_HUMAN
NC score	0.010066 (rank : 374)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	259	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P55771, Q99582, Q9UQR4	Gene names	PAX9
Domain Architecture
Description	Paired box protein Pax-9.

ITPR2_HUMAN
NC score	0.010045 (rank : 375)	θ value	5.27518 (rank : 219)
Query Neighborhood Hits	259	Target Neighborhood Hits	74	Shared Neighborhood Hits	5
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

NF2L2_HUMAN
NC score	0.009830 (rank : 376)	θ value	5.27518 (rank : 222)
Query Neighborhood Hits	259	Target Neighborhood Hits	109	Shared Neighborhood Hits	6
SwissProt Accessions	Q16236, Q96F71	Gene names	NFE2L2, NRF2
Domain Architecture
Description	Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

PHC1_MOUSE
NC score	0.009749 (rank : 377)	θ value	6.88961 (rank : 238)
Query Neighborhood Hits	259	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

DUS3L_HUMAN
NC score	0.009734 (rank : 378)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	259	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q96G46, Q96HM5, Q9BSU4, Q9H877, Q9NPR1	Gene names	DUS3L
Domain Architecture	No domain graphic available
Description	tRNA-dihydrouridine synthase 3-like (EC 1.-.-.-).

FIBB_HUMAN
NC score	0.009609 (rank : 379)	θ value	5.27518 (rank : 218)
Query Neighborhood Hits	259	Target Neighborhood Hits	101	Shared Neighborhood Hits	5
SwissProt Accessions	P02675	Gene names	FGB
Domain Architecture
Description	Fibrinogen beta chain precursor [Contains: Fibrinopeptide B].

ITPR2_MOUSE
NC score	0.009603 (rank : 380)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	259	Target Neighborhood Hits	69	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ZN638_MOUSE
NC score	0.009447 (rank : 381)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	259	Target Neighborhood Hits	318	Shared Neighborhood Hits	16
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

P53_MOUSE
NC score	0.009331 (rank : 382)	θ value	6.88961 (rank : 237)
Query Neighborhood Hits	259	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P02340, Q9QUP3	Gene names	Tp53, P53, Trp53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53).

MAGI1_HUMAN
NC score	0.009109 (rank : 383)	θ value	6.88961 (rank : 236)
Query Neighborhood Hits	259	Target Neighborhood Hits	388	Shared Neighborhood Hits	15
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

KI21B_HUMAN
NC score	0.008816 (rank : 384)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	259	Target Neighborhood Hits	1017	Shared Neighborhood Hits	37
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

FOXP2_HUMAN
NC score	0.008342 (rank : 385)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	259	Target Neighborhood Hits	366	Shared Neighborhood Hits	17
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

ANGL2_MOUSE
NC score	0.007014 (rank : 386)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	259	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	Q9R045	Gene names	Angptl2, Arp2
Domain Architecture
Description	Angiopoietin-related protein 2 precursor (Angiopoietin-like 2).

TRI14_MOUSE
NC score	0.006306 (rank : 387)	θ value	5.27518 (rank : 227)
Query Neighborhood Hits	259	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

BT2A1_HUMAN
NC score	0.003583 (rank : 388)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	259	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

USH2A_MOUSE
NC score	0.002722 (rank : 389)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	259	Target Neighborhood Hits	626	Shared Neighborhood Hits	10
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

ZN516_HUMAN
NC score	0.002553 (rank : 390)	θ value	0.163984 (rank : 96)
Query Neighborhood Hits	259	Target Neighborhood Hits	854	Shared Neighborhood Hits	13
SwissProt Accessions	Q92618	Gene names	ZNF516, KIAA0222
Domain Architecture	No domain graphic available
Description	Zinc finger protein 516.

MTF1_HUMAN
NC score	0.000216 (rank : 391)	θ value	0.21417 (rank : 100)
Query Neighborhood Hits	259	Target Neighborhood Hits	814	Shared Neighborhood Hits	10
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

MTF1_MOUSE
NC score	-0.000712 (rank : 392)	θ value	1.81305 (rank : 176)
Query Neighborhood Hits	259	Target Neighborhood Hits	785	Shared Neighborhood Hits	14
SwissProt Accessions	Q07243	Gene names	Mtf1, Mtf-1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

LTBP3_MOUSE
NC score	-0.001785 (rank : 393)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	259	Target Neighborhood Hits	475	Shared Neighborhood Hits	3
SwissProt Accessions	Q61810, Q8BNQ6	Gene names	Ltbp3
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 3 precursor (LTBP-3).