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Network neighborhood for query Sequence : WNK2_HUMAN

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WNK2_HUMAN
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

WNK1_MOUSE
θ value	0 (rank : 1)	NC score	0.967089 (rank : 3)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1179	Shared Neighborhood Hits	875
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1407	Shared Neighborhood Hits	1407
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK3_HUMAN
θ value	0 (rank : 3)	NC score	0.965377 (rank : 4)
Query Neighborhood Hits	1407	Target Neighborhood Hits	948	Shared Neighborhood Hits	780
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK1_HUMAN
θ value	2.56852e-180 (rank : 4)	NC score	0.969827 (rank : 2)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1158	Shared Neighborhood Hits	886
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK4_HUMAN
θ value	7.54289e-148 (rank : 5)	NC score	0.963387 (rank : 5)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1043	Shared Neighborhood Hits	867
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	3.87392e-144 (rank : 6)	NC score	0.961894 (rank : 6)
Query Neighborhood Hits	1407	Target Neighborhood Hits	961	Shared Neighborhood Hits	822
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

NRBP_HUMAN
θ value	5.22648e-32 (rank : 7)	NC score	0.665183 (rank : 761)
Query Neighborhood Hits	1407	Target Neighborhood Hits	448	Shared Neighborhood Hits	405
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	4.42448e-31 (rank : 8)	NC score	0.662236 (rank : 764)
Query Neighborhood Hits	1407	Target Neighborhood Hits	442	Shared Neighborhood Hits	402
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

M3K3_HUMAN
θ value	1.80048e-24 (rank : 9)	NC score	0.908408 (rank : 7)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	760
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	1.80048e-24 (rank : 10)	NC score	0.907748 (rank : 9)
Query Neighborhood Hits	1407	Target Neighborhood Hits	876	Shared Neighborhood Hits	758
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK6_HUMAN
θ value	3.07116e-24 (rank : 11)	NC score	0.906052 (rank : 14)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	756
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK7_HUMAN
θ value	1.99067e-23 (rank : 12)	NC score	0.905943 (rank : 16)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	3.39556e-23 (rank : 13)	NC score	0.906474 (rank : 12)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	756
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK6_MOUSE
θ value	5.79196e-23 (rank : 14)	NC score	0.906049 (rank : 15)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	756
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK4_MOUSE
θ value	7.56453e-23 (rank : 15)	NC score	0.906614 (rank : 11)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	763
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

YSK4_HUMAN
θ value	7.56453e-23 (rank : 16)	NC score	0.906791 (rank : 10)
Query Neighborhood Hits	1407	Target Neighborhood Hits	921	Shared Neighborhood Hits	763
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

NEK4_HUMAN
θ value	9.87957e-23 (rank : 17)	NC score	0.904897 (rank : 18)
Query Neighborhood Hits	1407	Target Neighborhood Hits	883	Shared Neighborhood Hits	756
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PAK2_HUMAN
θ value	1.29031e-22 (rank : 18)	NC score	0.903849 (rank : 25)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	759
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

M3K2_HUMAN
θ value	1.6852e-22 (rank : 19)	NC score	0.907863 (rank : 8)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

BRAF1_HUMAN
θ value	4.9032e-22 (rank : 20)	NC score	0.868051 (rank : 206)
Query Neighborhood Hits	1407	Target Neighborhood Hits	883	Shared Neighborhood Hits	755
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

M3K2_MOUSE
θ value	6.40375e-22 (rank : 21)	NC score	0.906306 (rank : 13)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	746
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

STK36_HUMAN
θ value	8.36355e-22 (rank : 22)	NC score	0.899331 (rank : 50)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	761
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PAK2_MOUSE
θ value	1.09232e-21 (rank : 23)	NC score	0.903367 (rank : 26)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

SLK_HUMAN
θ value	2.43343e-21 (rank : 24)	NC score	0.865649 (rank : 227)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1775	Shared Neighborhood Hits	814
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	2.43343e-21 (rank : 25)	NC score	0.867710 (rank : 211)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1798	Shared Neighborhood Hits	819
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

PAK1_HUMAN
θ value	3.17815e-21 (rank : 26)	NC score	0.902242 (rank : 32)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PLK4_HUMAN
θ value	4.15078e-21 (rank : 27)	NC score	0.888523 (rank : 92)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	758
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PAK3_MOUSE
θ value	5.42112e-21 (rank : 28)	NC score	0.901558 (rank : 36)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	759
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PLK2_HUMAN
θ value	5.42112e-21 (rank : 29)	NC score	0.893110 (rank : 73)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	5.42112e-21 (rank : 30)	NC score	0.892750 (rank : 75)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

M3K15_HUMAN
θ value	7.0802e-21 (rank : 31)	NC score	0.901564 (rank : 35)
Query Neighborhood Hits	1407	Target Neighborhood Hits	914	Shared Neighborhood Hits	758
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K4_HUMAN
θ value	7.0802e-21 (rank : 32)	NC score	0.904530 (rank : 20)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	7.0802e-21 (rank : 33)	NC score	0.904522 (rank : 21)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	770
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

PLK3_MOUSE
θ value	9.24701e-21 (rank : 34)	NC score	0.890521 (rank : 87)
Query Neighborhood Hits	1407	Target Neighborhood Hits	863	Shared Neighborhood Hits	758
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ULK1_HUMAN
θ value	9.24701e-21 (rank : 35)	NC score	0.896884 (rank : 60)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1121	Shared Neighborhood Hits	844
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

PAK3_HUMAN
θ value	1.2077e-20 (rank : 36)	NC score	0.901641 (rank : 33)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	763
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

NEK1_MOUSE
θ value	2.06002e-20 (rank : 37)	NC score	0.899084 (rank : 52)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1311	Shared Neighborhood Hits	800
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ULK1_MOUSE
θ value	2.06002e-20 (rank : 38)	NC score	0.895477 (rank : 61)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1214	Shared Neighborhood Hits	877
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

PLK3_HUMAN
θ value	2.69047e-20 (rank : 39)	NC score	0.890466 (rank : 88)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	757
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PAK1_MOUSE
θ value	3.51386e-20 (rank : 40)	NC score	0.901353 (rank : 38)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	759
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

RAF1_HUMAN
θ value	3.51386e-20 (rank : 41)	NC score	0.866128 (rank : 220)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	756
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MYLK_HUMAN
θ value	7.82807e-20 (rank : 42)	NC score	0.806228 (rank : 511)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1328	Shared Neighborhood Hits	777
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

OXSR1_HUMAN
θ value	7.82807e-20 (rank : 43)	NC score	0.903936 (rank : 24)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK25_HUMAN
θ value	7.82807e-20 (rank : 44)	NC score	0.901594 (rank : 34)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	755
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK4_HUMAN
θ value	7.82807e-20 (rank : 45)	NC score	0.901434 (rank : 37)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	754
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	7.82807e-20 (rank : 46)	NC score	0.901137 (rank : 40)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	754
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

MYLK_MOUSE
θ value	1.02238e-19 (rank : 47)	NC score	0.806154 (rank : 512)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1489	Shared Neighborhood Hits	828
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

ULK3_MOUSE
θ value	1.02238e-19 (rank : 48)	NC score	0.891074 (rank : 83)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	754
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK25_MOUSE
θ value	1.33526e-19 (rank : 49)	NC score	0.901341 (rank : 39)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	755
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK2_HUMAN
θ value	1.74391e-19 (rank : 50)	NC score	0.905169 (rank : 17)
Query Neighborhood Hits	1407	Target Neighborhood Hits	908	Shared Neighborhood Hits	760
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

PLK4_MOUSE
θ value	1.74391e-19 (rank : 51)	NC score	0.888769 (rank : 90)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

NEK8_MOUSE
θ value	2.27762e-19 (rank : 52)	NC score	0.890525 (rank : 86)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	753
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NIM1_HUMAN
θ value	2.27762e-19 (rank : 53)	NC score	0.888685 (rank : 91)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	752
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

RAF1_MOUSE
θ value	2.27762e-19 (rank : 54)	NC score	0.865747 (rank : 226)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	760
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

STK39_HUMAN
θ value	2.27762e-19 (rank : 55)	NC score	0.902700 (rank : 29)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	2.27762e-19 (rank : 56)	NC score	0.903282 (rank : 28)
Query Neighborhood Hits	1407	Target Neighborhood Hits	915	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TAOK3_HUMAN
θ value	2.27762e-19 (rank : 57)	NC score	0.864797 (rank : 234)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1494	Shared Neighborhood Hits	788
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

NEK8_HUMAN
θ value	2.97466e-19 (rank : 58)	NC score	0.890893 (rank : 85)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	754
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

OXSR1_MOUSE
θ value	2.97466e-19 (rank : 59)	NC score	0.903356 (rank : 27)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	758
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

M3K10_HUMAN
θ value	5.07402e-19 (rank : 60)	NC score	0.856958 (rank : 278)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1071	Shared Neighborhood Hits	780
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MLTK_MOUSE
θ value	5.07402e-19 (rank : 61)	NC score	0.861064 (rank : 259)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	749
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

NIM1_MOUSE
θ value	5.07402e-19 (rank : 62)	NC score	0.887366 (rank : 95)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	751
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

M3K5_HUMAN
θ value	8.65492e-19 (rank : 63)	NC score	0.897355 (rank : 59)
Query Neighborhood Hits	1407	Target Neighborhood Hits	868	Shared Neighborhood Hits	752
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MLTK_HUMAN
θ value	8.65492e-19 (rank : 64)	NC score	0.860823 (rank : 261)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

KPCD2_HUMAN
θ value	1.13037e-18 (rank : 65)	NC score	0.874539 (rank : 166)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	748
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

BRSK1_HUMAN
θ value	1.47631e-18 (rank : 66)	NC score	0.881830 (rank : 126)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	785
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

M3K5_MOUSE
θ value	1.47631e-18 (rank : 67)	NC score	0.897565 (rank : 58)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	1.47631e-18 (rank : 68)	NC score	0.904363 (rank : 22)
Query Neighborhood Hits	1407	Target Neighborhood Hits	889	Shared Neighborhood Hits	773
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

TAOK1_HUMAN
θ value	1.47631e-18 (rank : 69)	NC score	0.850272 (rank : 316)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1734	Shared Neighborhood Hits	809
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	1.47631e-18 (rank : 70)	NC score	0.850647 (rank : 312)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1720	Shared Neighborhood Hits	806
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

BRSK2_HUMAN
θ value	1.92812e-18 (rank : 71)	NC score	0.882875 (rank : 116)
Query Neighborhood Hits	1407	Target Neighborhood Hits	897	Shared Neighborhood Hits	772
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

STK3_HUMAN
θ value	1.92812e-18 (rank : 72)	NC score	0.901076 (rank : 41)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	754
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK6_MOUSE
θ value	2.5182e-18 (rank : 73)	NC score	0.891489 (rank : 80)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	764
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TAOK3_MOUSE
θ value	2.5182e-18 (rank : 74)	NC score	0.867427 (rank : 215)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1458	Shared Neighborhood Hits	783
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

ARAF_HUMAN
θ value	3.28887e-18 (rank : 75)	NC score	0.860646 (rank : 263)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	768
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

STK3_MOUSE
θ value	4.29542e-18 (rank : 76)	NC score	0.900582 (rank : 43)
Query Neighborhood Hits	1407	Target Neighborhood Hits	869	Shared Neighborhood Hits	754
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK24_HUMAN
θ value	5.60996e-18 (rank : 77)	NC score	0.900521 (rank : 44)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

M3K13_HUMAN
θ value	7.32683e-18 (rank : 78)	NC score	0.877037 (rank : 158)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	767
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MYO3A_MOUSE
θ value	7.32683e-18 (rank : 79)	NC score	0.785604 (rank : 540)
Query Neighborhood Hits	1407	Target Neighborhood Hits	902	Shared Neighborhood Hits	745
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

ULK3_HUMAN
θ value	7.32683e-18 (rank : 80)	NC score	0.895382 (rank : 62)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	740
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

NEK1_HUMAN
θ value	9.56915e-18 (rank : 81)	NC score	0.899242 (rank : 51)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1129	Shared Neighborhood Hits	777
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

PAK6_HUMAN
θ value	9.56915e-18 (rank : 82)	NC score	0.902639 (rank : 30)
Query Neighborhood Hits	1407	Target Neighborhood Hits	915	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

ST17A_HUMAN
θ value	9.56915e-18 (rank : 83)	NC score	0.873790 (rank : 170)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	731
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

STK24_MOUSE
θ value	9.56915e-18 (rank : 84)	NC score	0.900366 (rank : 45)
Query Neighborhood Hits	1407	Target Neighborhood Hits	856	Shared Neighborhood Hits	757
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

KPCD3_MOUSE
θ value	1.24977e-17 (rank : 85)	NC score	0.869466 (rank : 200)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	740
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

M3K1_MOUSE
θ value	1.24977e-17 (rank : 86)	NC score	0.904293 (rank : 23)
Query Neighborhood Hits	1407	Target Neighborhood Hits	952	Shared Neighborhood Hits	784
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

KPCD3_HUMAN
θ value	1.63225e-17 (rank : 87)	NC score	0.869711 (rank : 198)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	742
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

TNIK_HUMAN
θ value	1.63225e-17 (rank : 88)	NC score	0.875817 (rank : 163)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1570	Shared Neighborhood Hits	837
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

KCC2D_HUMAN
θ value	2.13179e-17 (rank : 89)	NC score	0.865018 (rank : 230)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	741
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

MYO3A_HUMAN
θ value	2.13179e-17 (rank : 90)	NC score	0.779040 (rank : 550)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1033	Shared Neighborhood Hits	757
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NEK3_MOUSE
θ value	2.13179e-17 (rank : 91)	NC score	0.899632 (rank : 48)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	753
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

K0999_HUMAN
θ value	2.7842e-17 (rank : 92)	NC score	0.880454 (rank : 134)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	2.7842e-17 (rank : 93)	NC score	0.880473 (rank : 133)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	772
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KPCD1_HUMAN
θ value	2.7842e-17 (rank : 94)	NC score	0.872232 (rank : 178)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	742
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
θ value	2.7842e-17 (rank : 95)	NC score	0.872106 (rank : 179)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	742
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

STK6_HUMAN
θ value	2.7842e-17 (rank : 96)	NC score	0.891757 (rank : 79)
Query Neighborhood Hits	1407	Target Neighborhood Hits	916	Shared Neighborhood Hits	769
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

TLK2_HUMAN
θ value	2.7842e-17 (rank : 97)	NC score	0.872237 (rank : 177)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1044	Shared Neighborhood Hits	742
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	2.7842e-17 (rank : 98)	NC score	0.869832 (rank : 197)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1088	Shared Neighborhood Hits	740
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

AURKC_HUMAN
θ value	3.63628e-17 (rank : 99)	NC score	0.891846 (rank : 77)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

MP2K1_HUMAN
θ value	3.63628e-17 (rank : 100)	NC score	0.894105 (rank : 67)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

KCC1G_HUMAN
θ value	4.74913e-17 (rank : 101)	NC score	0.868025 (rank : 207)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	744
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MARK4_HUMAN
θ value	4.74913e-17 (rank : 102)	NC score	0.883873 (rank : 110)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	769
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	4.74913e-17 (rank : 103)	NC score	0.883686 (rank : 113)
Query Neighborhood Hits	1407	Target Neighborhood Hits	898	Shared Neighborhood Hits	769
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MP2K1_MOUSE
θ value	4.74913e-17 (rank : 104)	NC score	0.894039 (rank : 68)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK3_HUMAN
θ value	4.74913e-17 (rank : 105)	NC score	0.898864 (rank : 54)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	755
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

ARAF_MOUSE
θ value	6.20254e-17 (rank : 106)	NC score	0.859588 (rank : 268)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

DAPK2_MOUSE
θ value	6.20254e-17 (rank : 107)	NC score	0.875708 (rank : 164)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	740
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KCC2G_HUMAN
θ value	6.20254e-17 (rank : 108)	NC score	0.866080 (rank : 223)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	742
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	6.20254e-17 (rank : 109)	NC score	0.866082 (rank : 222)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	743
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

STK10_HUMAN
θ value	6.20254e-17 (rank : 110)	NC score	0.847227 (rank : 337)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1921	Shared Neighborhood Hits	845
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

AURKC_MOUSE
θ value	8.10077e-17 (rank : 111)	NC score	0.891384 (rank : 81)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	754
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

DAPK3_HUMAN
θ value	8.10077e-17 (rank : 112)	NC score	0.876148 (rank : 162)
Query Neighborhood Hits	1407	Target Neighborhood Hits	945	Shared Neighborhood Hits	741
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

E2AK2_MOUSE
θ value	1.058e-16 (rank : 113)	NC score	0.897876 (rank : 57)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	751
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

M3K11_HUMAN
θ value	1.058e-16 (rank : 114)	NC score	0.854239 (rank : 297)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1136	Shared Neighborhood Hits	831
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MARK2_HUMAN
θ value	1.058e-16 (rank : 115)	NC score	0.882620 (rank : 118)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	811
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

STK36_MOUSE
θ value	1.058e-16 (rank : 116)	NC score	0.895063 (rank : 63)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	759
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

KCC2A_HUMAN
θ value	1.38178e-16 (rank : 117)	NC score	0.864700 (rank : 235)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

MARK1_HUMAN
θ value	1.38178e-16 (rank : 118)	NC score	0.881510 (rank : 128)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	758
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

NEK9_HUMAN
θ value	1.38178e-16 (rank : 119)	NC score	0.885934 (rank : 102)
Query Neighborhood Hits	1407	Target Neighborhood Hits	900	Shared Neighborhood Hits	760
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

DAPK3_MOUSE
θ value	1.80466e-16 (rank : 120)	NC score	0.877432 (rank : 155)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	737
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

PAK7_MOUSE
θ value	1.80466e-16 (rank : 121)	NC score	0.899553 (rank : 49)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	759
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

STK10_MOUSE
θ value	1.80466e-16 (rank : 122)	NC score	0.825311 (rank : 457)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2132	Shared Neighborhood Hits	858
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DAPK1_HUMAN
θ value	2.35696e-16 (rank : 123)	NC score	0.793888 (rank : 525)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1130	Shared Neighborhood Hits	757
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KCC2B_HUMAN
θ value	2.35696e-16 (rank : 124)	NC score	0.862848 (rank : 251)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	756
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

TAOK2_MOUSE
θ value	2.35696e-16 (rank : 125)	NC score	0.876259 (rank : 161)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1373	Shared Neighborhood Hits	801
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

ULK2_MOUSE
θ value	2.35696e-16 (rank : 126)	NC score	0.894895 (rank : 64)
Query Neighborhood Hits	1407	Target Neighborhood Hits	943	Shared Neighborhood Hits	785
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

AKT1_MOUSE
θ value	3.07829e-16 (rank : 127)	NC score	0.846482 (rank : 346)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	751
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

JAK2_HUMAN
θ value	3.07829e-16 (rank : 128)	NC score	0.814469 (rank : 488)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	748
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	3.07829e-16 (rank : 129)	NC score	0.812622 (rank : 494)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	744
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

MP2K2_MOUSE
θ value	3.07829e-16 (rank : 130)	NC score	0.894019 (rank : 69)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	746
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

TLK1_HUMAN
θ value	3.07829e-16 (rank : 131)	NC score	0.874171 (rank : 167)
Query Neighborhood Hits	1407	Target Neighborhood Hits	967	Shared Neighborhood Hits	732
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	3.07829e-16 (rank : 132)	NC score	0.874047 (rank : 168)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	728
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

KCC2B_MOUSE
θ value	4.02038e-16 (rank : 133)	NC score	0.860086 (rank : 265)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	740
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

MARK3_MOUSE
θ value	4.02038e-16 (rank : 134)	NC score	0.881788 (rank : 127)
Query Neighborhood Hits	1407	Target Neighborhood Hits	919	Shared Neighborhood Hits	771
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

NEK11_MOUSE
θ value	4.02038e-16 (rank : 135)	NC score	0.902515 (rank : 31)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	756
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK7_HUMAN
θ value	4.02038e-16 (rank : 136)	NC score	0.899764 (rank : 47)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	758
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

DAPK2_HUMAN
θ value	5.25075e-16 (rank : 137)	NC score	0.871631 (rank : 180)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	736
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MARK1_MOUSE
θ value	5.25075e-16 (rank : 138)	NC score	0.881846 (rank : 125)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	762
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

NEK9_MOUSE
θ value	5.25075e-16 (rank : 139)	NC score	0.884619 (rank : 104)
Query Neighborhood Hits	1407	Target Neighborhood Hits	890	Shared Neighborhood Hits	760
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

STK33_HUMAN
θ value	5.25075e-16 (rank : 140)	NC score	0.887224 (rank : 96)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	752
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

ULK2_HUMAN
θ value	5.25075e-16 (rank : 141)	NC score	0.893925 (rank : 70)
Query Neighborhood Hits	1407	Target Neighborhood Hits	979	Shared Neighborhood Hits	795
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

AKT1_HUMAN
θ value	6.85773e-16 (rank : 142)	NC score	0.846542 (rank : 343)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	751
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

DAPK1_MOUSE
θ value	6.85773e-16 (rank : 143)	NC score	0.790211 (rank : 529)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1138	Shared Neighborhood Hits	756
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KCC1G_MOUSE
θ value	6.85773e-16 (rank : 144)	NC score	0.867961 (rank : 209)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	748
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M3K7_HUMAN
θ value	6.85773e-16 (rank : 145)	NC score	0.870053 (rank : 194)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	753
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	6.85773e-16 (rank : 146)	NC score	0.870285 (rank : 189)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	754
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

NEK11_HUMAN
θ value	6.85773e-16 (rank : 147)	NC score	0.899822 (rank : 46)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1043	Shared Neighborhood Hits	772
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK2_MOUSE
θ value	6.85773e-16 (rank : 148)	NC score	0.904706 (rank : 19)
Query Neighborhood Hits	1407	Target Neighborhood Hits	876	Shared Neighborhood Hits	754
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TAOK2_HUMAN
θ value	6.85773e-16 (rank : 149)	NC score	0.889280 (rank : 89)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1172	Shared Neighborhood Hits	790
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

M3K12_HUMAN
θ value	8.95645e-16 (rank : 150)	NC score	0.870867 (rank : 184)
Query Neighborhood Hits	1407	Target Neighborhood Hits	940	Shared Neighborhood Hits	784
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	8.95645e-16 (rank : 151)	NC score	0.870589 (rank : 187)
Query Neighborhood Hits	1407	Target Neighborhood Hits	957	Shared Neighborhood Hits	780
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

NUAK2_HUMAN
θ value	8.95645e-16 (rank : 152)	NC score	0.883170 (rank : 115)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	759
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

SN1L2_MOUSE
θ value	8.95645e-16 (rank : 153)	NC score	0.881509 (rank : 129)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	806
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

AKT2_HUMAN
θ value	1.16975e-15 (rank : 154)	NC score	0.849604 (rank : 317)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	747
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

MINK1_MOUSE
θ value	1.16975e-15 (rank : 155)	NC score	0.877197 (rank : 156)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1451	Shared Neighborhood Hits	831
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PAK4_HUMAN
θ value	1.16975e-15 (rank : 156)	NC score	0.900597 (rank : 42)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	798
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PLK1_MOUSE
θ value	1.16975e-15 (rank : 157)	NC score	0.886618 (rank : 99)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	749
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

SN1L2_HUMAN
θ value	1.16975e-15 (rank : 158)	NC score	0.882204 (rank : 121)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	818
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

AKT3_HUMAN
θ value	1.52774e-15 (rank : 159)	NC score	0.851275 (rank : 307)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	748
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	1.52774e-15 (rank : 160)	NC score	0.851248 (rank : 308)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

MINK1_HUMAN
θ value	1.99529e-15 (rank : 161)	NC score	0.877642 (rank : 151)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1477	Shared Neighborhood Hits	846
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

KCC2A_MOUSE
θ value	2.60593e-15 (rank : 162)	NC score	0.862211 (rank : 253)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	737
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

MST4_HUMAN
θ value	2.60593e-15 (rank : 163)	NC score	0.898399 (rank : 56)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	754
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	3.40345e-15 (rank : 164)	NC score	0.898439 (rank : 55)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	754
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

DCAK2_MOUSE
θ value	4.44505e-15 (rank : 165)	NC score	0.859980 (rank : 266)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	744
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KAPCA_HUMAN
θ value	4.44505e-15 (rank : 166)	NC score	0.849358 (rank : 321)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

M4K2_MOUSE
θ value	4.44505e-15 (rank : 167)	NC score	0.891341 (rank : 82)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	748
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

MP2K2_HUMAN
θ value	4.44505e-15 (rank : 168)	NC score	0.893832 (rank : 71)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	746
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

DCAK2_HUMAN
θ value	5.8054e-15 (rank : 169)	NC score	0.859051 (rank : 270)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	745
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

M4K1_MOUSE
θ value	5.8054e-15 (rank : 170)	NC score	0.893429 (rank : 72)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	759
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	5.8054e-15 (rank : 171)	NC score	0.890992 (rank : 84)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	756
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

AKT2_MOUSE
θ value	7.58209e-15 (rank : 172)	NC score	0.848794 (rank : 324)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	747
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

PLK1_HUMAN
θ value	7.58209e-15 (rank : 173)	NC score	0.887670 (rank : 94)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	749
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

SNRK_HUMAN
θ value	7.58209e-15 (rank : 174)	NC score	0.877717 (rank : 150)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KAPCA_MOUSE
θ value	9.90251e-15 (rank : 175)	NC score	0.848690 (rank : 327)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

M4K3_HUMAN
θ value	9.90251e-15 (rank : 176)	NC score	0.892685 (rank : 76)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	758
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MARK2_MOUSE
θ value	9.90251e-15 (rank : 177)	NC score	0.881214 (rank : 131)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1018	Shared Neighborhood Hits	804
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

SN1L1_MOUSE
θ value	9.90251e-15 (rank : 178)	NC score	0.879426 (rank : 140)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	768
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KAPCB_MOUSE
θ value	1.29331e-14 (rank : 179)	NC score	0.847468 (rank : 333)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	748
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

E2AK2_HUMAN
θ value	1.68911e-14 (rank : 180)	NC score	0.894234 (rank : 66)
Query Neighborhood Hits	1407	Target Neighborhood Hits	856	Shared Neighborhood Hits	743
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

MUC1_HUMAN
θ value	1.68911e-14 (rank : 181)	NC score	0.089943 (rank : 899)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	300
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

AURKB_HUMAN
θ value	2.20605e-14 (rank : 182)	NC score	0.886130 (rank : 101)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	753
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

KCC4_MOUSE
θ value	2.20605e-14 (rank : 183)	NC score	0.867984 (rank : 208)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	752
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

LIMK1_MOUSE
θ value	2.20605e-14 (rank : 184)	NC score	0.834063 (rank : 416)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1008	Shared Neighborhood Hits	758
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

M3KL4_HUMAN
θ value	2.20605e-14 (rank : 185)	NC score	0.837724 (rank : 391)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1087	Shared Neighborhood Hits	779
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

HUNK_HUMAN
θ value	2.88119e-14 (rank : 186)	NC score	0.882010 (rank : 124)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	759
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

LIMK1_HUMAN
θ value	2.88119e-14 (rank : 187)	NC score	0.835131 (rank : 410)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LRRK1_MOUSE
θ value	2.88119e-14 (rank : 188)	NC score	0.771872 (rank : 569)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1267	Shared Neighborhood Hits	740
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

SN1L1_HUMAN
θ value	2.88119e-14 (rank : 189)	NC score	0.878764 (rank : 146)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	776
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

IRAK4_MOUSE
θ value	3.76295e-14 (rank : 190)	NC score	0.871011 (rank : 182)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	735
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

KKCC2_HUMAN
θ value	3.76295e-14 (rank : 191)	NC score	0.879747 (rank : 137)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	749
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	3.76295e-14 (rank : 192)	NC score	0.879744 (rank : 138)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	751
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

M3K9_HUMAN
θ value	3.76295e-14 (rank : 193)	NC score	0.850528 (rank : 313)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	795
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M4K5_MOUSE
θ value	3.76295e-14 (rank : 194)	NC score	0.887936 (rank : 93)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MP2K5_MOUSE
θ value	3.76295e-14 (rank : 195)	NC score	0.894792 (rank : 65)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	749
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NUAK1_MOUSE
θ value	3.76295e-14 (rank : 196)	NC score	0.883534 (rank : 114)
Query Neighborhood Hits	1407	Target Neighborhood Hits	881	Shared Neighborhood Hits	765
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_MOUSE
θ value	3.76295e-14 (rank : 197)	NC score	0.880888 (rank : 132)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	756
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

AURKB_MOUSE
θ value	4.91457e-14 (rank : 198)	NC score	0.886135 (rank : 100)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	758
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

KAPCB_HUMAN
θ value	4.91457e-14 (rank : 199)	NC score	0.847338 (rank : 335)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

M4K5_HUMAN
θ value	4.91457e-14 (rank : 200)	NC score	0.887091 (rank : 98)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PHKG1_HUMAN
θ value	4.91457e-14 (rank : 201)	NC score	0.872568 (rank : 175)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	748
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	4.91457e-14 (rank : 202)	NC score	0.870918 (rank : 183)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	746
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	4.91457e-14 (rank : 203)	NC score	0.873042 (rank : 171)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	747
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

BMX_MOUSE
θ value	6.41864e-14 (rank : 204)	NC score	0.778837 (rank : 551)
Query Neighborhood Hits	1407	Target Neighborhood Hits	912	Shared Neighborhood Hits	733
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

HUNK_MOUSE
θ value	6.41864e-14 (rank : 205)	NC score	0.882146 (rank : 122)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	757
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

IKKB_HUMAN
θ value	6.41864e-14 (rank : 206)	NC score	0.879908 (rank : 136)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	755
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KKCC1_HUMAN
θ value	6.41864e-14 (rank : 207)	NC score	0.876570 (rank : 159)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	753
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCZ_HUMAN
θ value	6.41864e-14 (rank : 208)	NC score	0.832169 (rank : 430)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	749
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPSH1_HUMAN
θ value	6.41864e-14 (rank : 209)	NC score	0.867443 (rank : 214)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	745
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

LIMK2_HUMAN
θ value	6.41864e-14 (rank : 210)	NC score	0.841532 (rank : 373)
Query Neighborhood Hits	1407	Target Neighborhood Hits	986	Shared Neighborhood Hits	749
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	6.41864e-14 (rank : 211)	NC score	0.838797 (rank : 382)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	747
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MP2K3_MOUSE
θ value	6.41864e-14 (rank : 212)	NC score	0.881476 (rank : 130)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

NRK_HUMAN
θ value	6.41864e-14 (rank : 213)	NC score	0.879462 (rank : 139)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	753
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

JAK3_HUMAN
θ value	8.38298e-14 (rank : 214)	NC score	0.793796 (rank : 526)
Query Neighborhood Hits	1407	Target Neighborhood Hits	827	Shared Neighborhood Hits	746
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

KPCZ_MOUSE
θ value	8.38298e-14 (rank : 215)	NC score	0.831972 (rank : 432)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	749
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

M4K1_HUMAN
θ value	1.09485e-13 (rank : 216)	NC score	0.891800 (rank : 78)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	764
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

STK11_HUMAN
θ value	1.09485e-13 (rank : 217)	NC score	0.884932 (rank : 103)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

IRAK4_HUMAN
θ value	1.42992e-13 (rank : 218)	NC score	0.867415 (rank : 216)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	736
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

ITK_MOUSE
θ value	1.42992e-13 (rank : 219)	NC score	0.775688 (rank : 559)
Query Neighborhood Hits	1407	Target Neighborhood Hits	985	Shared Neighborhood Hits	749
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KAPCG_HUMAN
θ value	1.42992e-13 (rank : 220)	NC score	0.853465 (rank : 301)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	751
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KKCC1_MOUSE
θ value	1.42992e-13 (rank : 221)	NC score	0.877121 (rank : 157)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	755
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KS6A1_HUMAN
θ value	1.42992e-13 (rank : 222)	NC score	0.850285 (rank : 315)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	756
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MYO3B_HUMAN
θ value	1.42992e-13 (rank : 223)	NC score	0.772144 (rank : 568)
Query Neighborhood Hits	1407	Target Neighborhood Hits	923	Shared Neighborhood Hits	754
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NUAK1_HUMAN
θ value	1.42992e-13 (rank : 224)	NC score	0.884601 (rank : 105)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	760
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

SGK3_MOUSE
θ value	1.42992e-13 (rank : 225)	NC score	0.846867 (rank : 340)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	748
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

ST17B_MOUSE
θ value	1.42992e-13 (rank : 226)	NC score	0.879916 (rank : 135)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	739
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

BMX_HUMAN
θ value	1.86753e-13 (rank : 227)	NC score	0.779360 (rank : 549)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	736
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ITK_HUMAN
θ value	1.86753e-13 (rank : 228)	NC score	0.775005 (rank : 561)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1016	Shared Neighborhood Hits	751
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

KPSH1_MOUSE
θ value	1.86753e-13 (rank : 229)	NC score	0.867935 (rank : 210)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	743
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MP2K4_HUMAN
θ value	1.86753e-13 (rank : 230)	NC score	0.883924 (rank : 109)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	751
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.86753e-13 (rank : 231)	NC score	0.883807 (rank : 112)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

SNRK_MOUSE
θ value	1.86753e-13 (rank : 232)	NC score	0.877521 (rank : 153)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	739
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

TNI3K_HUMAN
θ value	1.86753e-13 (rank : 233)	NC score	0.748050 (rank : 628)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1084	Shared Neighborhood Hits	742
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ERBB4_HUMAN
θ value	2.43908e-13 (rank : 234)	NC score	0.751417 (rank : 615)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	745
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

SGK1_HUMAN
θ value	2.43908e-13 (rank : 235)	NC score	0.855361 (rank : 287)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	753
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AAPK1_HUMAN
θ value	3.18553e-13 (rank : 236)	NC score	0.882809 (rank : 117)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	3.18553e-13 (rank : 237)	NC score	0.882455 (rank : 120)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	749
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

CDC2_HUMAN
θ value	3.18553e-13 (rank : 238)	NC score	0.863114 (rank : 250)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	754
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	3.18553e-13 (rank : 239)	NC score	0.862799 (rank : 252)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	751
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK4_HUMAN
θ value	3.18553e-13 (rank : 240)	NC score	0.840589 (rank : 376)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

KCC4_HUMAN
θ value	3.18553e-13 (rank : 241)	NC score	0.867559 (rank : 213)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	742
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MP2K6_HUMAN
θ value	3.18553e-13 (rank : 242)	NC score	0.883824 (rank : 111)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	743
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

SON_HUMAN
θ value	3.18553e-13 (rank : 243)	NC score	0.113221 (rank : 861)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1568	Shared Neighborhood Hits	415
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CDK3_HUMAN
θ value	4.16044e-13 (rank : 244)	NC score	0.855573 (rank : 286)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	748
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

MP2K6_MOUSE
θ value	4.16044e-13 (rank : 245)	NC score	0.884452 (rank : 107)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	744
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PAK4_MOUSE
θ value	4.16044e-13 (rank : 246)	NC score	0.899011 (rank : 53)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1098	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

IKKB_MOUSE
θ value	5.43371e-13 (rank : 247)	NC score	0.876340 (rank : 160)
Query Neighborhood Hits	1407	Target Neighborhood Hits	984	Shared Neighborhood Hits	751
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KCC1B_HUMAN
θ value	5.43371e-13 (rank : 248)	NC score	0.868169 (rank : 205)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

M4K4_HUMAN
θ value	5.43371e-13 (rank : 249)	NC score	0.860905 (rank : 260)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1589	Shared Neighborhood Hits	794
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MP2K3_HUMAN
θ value	5.43371e-13 (rank : 250)	NC score	0.879292 (rank : 141)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	742
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PFTK1_HUMAN
θ value	5.43371e-13 (rank : 251)	NC score	0.853941 (rank : 298)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	742
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PTK6_HUMAN
θ value	5.43371e-13 (rank : 252)	NC score	0.782587 (rank : 544)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	757
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TNI3K_MOUSE
θ value	5.43371e-13 (rank : 253)	NC score	0.753049 (rank : 612)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1079	Shared Neighborhood Hits	736
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CSKP_MOUSE
θ value	7.09661e-13 (rank : 254)	NC score	0.818853 (rank : 475)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1027	Shared Neighborhood Hits	740
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DCAK3_HUMAN
θ value	7.09661e-13 (rank : 255)	NC score	0.870100 (rank : 192)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	752
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

IKKA_HUMAN
θ value	7.09661e-13 (rank : 256)	NC score	0.877623 (rank : 152)
Query Neighborhood Hits	1407	Target Neighborhood Hits	863	Shared Neighborhood Hits	747
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SGK1_MOUSE
θ value	7.09661e-13 (rank : 257)	NC score	0.854819 (rank : 293)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SRC_HUMAN
θ value	7.09661e-13 (rank : 258)	NC score	0.751000 (rank : 618)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	755
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TSSK2_MOUSE
θ value	7.09661e-13 (rank : 259)	NC score	0.864046 (rank : 240)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	732
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

DUET_HUMAN
θ value	9.26847e-13 (rank : 260)	NC score	0.788292 (rank : 534)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1220	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

EGFR_HUMAN
θ value	9.26847e-13 (rank : 261)	NC score	0.747448 (rank : 631)
Query Neighborhood Hits	1407	Target Neighborhood Hits	939	Shared Neighborhood Hits	739
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	9.26847e-13 (rank : 262)	NC score	0.747956 (rank : 629)
Query Neighborhood Hits	1407	Target Neighborhood Hits	927	Shared Neighborhood Hits	741
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

KCC1D_HUMAN
θ value	9.26847e-13 (rank : 263)	NC score	0.864173 (rank : 239)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	744
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KS6A2_HUMAN
θ value	9.26847e-13 (rank : 264)	NC score	0.851904 (rank : 305)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	759
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	9.26847e-13 (rank : 265)	NC score	0.849579 (rank : 319)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	760
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	9.26847e-13 (rank : 266)	NC score	0.849599 (rank : 318)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	760
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PRAX_HUMAN
θ value	9.26847e-13 (rank : 267)	NC score	0.081480 (rank : 927)
Query Neighborhood Hits	1407	Target Neighborhood Hits	215	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

RK_HUMAN
θ value	9.26847e-13 (rank : 268)	NC score	0.845269 (rank : 356)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	741
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

TSSK2_HUMAN
θ value	9.26847e-13 (rank : 269)	NC score	0.870255 (rank : 191)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	738
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

IKKA_MOUSE
θ value	1.2105e-12 (rank : 270)	NC score	0.878844 (rank : 145)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KCC1B_MOUSE
θ value	1.2105e-12 (rank : 271)	NC score	0.868359 (rank : 204)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_MOUSE
θ value	1.2105e-12 (rank : 272)	NC score	0.864026 (rank : 241)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KPCT_MOUSE
θ value	1.2105e-12 (rank : 273)	NC score	0.844072 (rank : 360)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	753
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LRRK1_HUMAN
θ value	1.2105e-12 (rank : 274)	NC score	0.771183 (rank : 571)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1237	Shared Neighborhood Hits	734
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

NRK_MOUSE
θ value	1.2105e-12 (rank : 275)	NC score	0.879171 (rank : 142)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	756
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PFTK1_MOUSE
θ value	1.2105e-12 (rank : 276)	NC score	0.853604 (rank : 300)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	742
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PRKY_HUMAN
θ value	1.2105e-12 (rank : 277)	NC score	0.866076 (rank : 224)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	754
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

SRC_MOUSE
θ value	1.2105e-12 (rank : 278)	NC score	0.748501 (rank : 625)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1033	Shared Neighborhood Hits	754
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

AAPK2_HUMAN
θ value	1.58096e-12 (rank : 279)	NC score	0.879125 (rank : 143)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	749
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KS6A1_MOUSE
θ value	1.58096e-12 (rank : 280)	NC score	0.846039 (rank : 349)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	753
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PRKX_HUMAN
θ value	1.58096e-12 (rank : 281)	NC score	0.855917 (rank : 284)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	752
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

TESK1_HUMAN
θ value	1.58096e-12 (rank : 282)	NC score	0.870609 (rank : 186)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	762
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	1.58096e-12 (rank : 283)	NC score	0.871495 (rank : 181)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	764
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

CSKP_HUMAN
θ value	2.0648e-12 (rank : 284)	NC score	0.816204 (rank : 483)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1022	Shared Neighborhood Hits	738
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

EPHB1_HUMAN
θ value	2.0648e-12 (rank : 285)	NC score	0.743346 (rank : 639)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	751
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

ERN1_HUMAN
θ value	2.0648e-12 (rank : 286)	NC score	0.858311 (rank : 274)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	735
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KCC1A_MOUSE
θ value	2.0648e-12 (rank : 287)	NC score	0.865533 (rank : 228)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	747
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MP2K7_HUMAN
θ value	2.0648e-12 (rank : 288)	NC score	0.887135 (rank : 97)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	748
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

ST17B_HUMAN
θ value	2.0648e-12 (rank : 289)	NC score	0.874585 (rank : 165)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	735
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TTK_MOUSE
θ value	2.0648e-12 (rank : 290)	NC score	0.834797 (rank : 412)
Query Neighborhood Hits	1407	Target Neighborhood Hits	803	Shared Neighborhood Hits	691
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

CDK4_MOUSE
θ value	2.69671e-12 (rank : 291)	NC score	0.841501 (rank : 374)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDKL2_MOUSE
θ value	2.69671e-12 (rank : 292)	NC score	0.860660 (rank : 262)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	748
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

PCTK3_MOUSE
θ value	2.69671e-12 (rank : 293)	NC score	0.847284 (rank : 336)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	744
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

RIPK2_MOUSE
θ value	2.69671e-12 (rank : 294)	NC score	0.822727 (rank : 462)
Query Neighborhood Hits	1407	Target Neighborhood Hits	776	Shared Neighborhood Hits	707
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

SGK3_HUMAN
θ value	2.69671e-12 (rank : 295)	NC score	0.846541 (rank : 344)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	748
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

AL2S7_HUMAN
θ value	3.52202e-12 (rank : 296)	NC score	0.848730 (rank : 326)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	743
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CDK5_HUMAN
θ value	3.52202e-12 (rank : 297)	NC score	0.846515 (rank : 345)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	3.52202e-12 (rank : 298)	NC score	0.846443 (rank : 347)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDKL3_HUMAN
θ value	3.52202e-12 (rank : 299)	NC score	0.865825 (rank : 225)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	749
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	3.52202e-12 (rank : 300)	NC score	0.866098 (rank : 221)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	751
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

DCAK1_MOUSE
θ value	3.52202e-12 (rank : 301)	NC score	0.856297 (rank : 280)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	746
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

FER_HUMAN
θ value	3.52202e-12 (rank : 302)	NC score	0.773291 (rank : 566)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1278	Shared Neighborhood Hits	753
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

KS6A2_MOUSE
θ value	3.52202e-12 (rank : 303)	NC score	0.851669 (rank : 306)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A6_HUMAN
θ value	3.52202e-12 (rank : 304)	NC score	0.848269 (rank : 329)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	753
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

MP2K5_HUMAN
θ value	3.52202e-12 (rank : 305)	NC score	0.892961 (rank : 74)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

ULK4_MOUSE
θ value	3.52202e-12 (rank : 306)	NC score	0.869920 (rank : 196)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	706
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

CDK6_MOUSE
θ value	4.59992e-12 (rank : 307)	NC score	0.848764 (rank : 325)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

GAK_MOUSE
θ value	4.59992e-12 (rank : 308)	NC score	0.826520 (rank : 454)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	767
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KCC1A_HUMAN
θ value	4.59992e-12 (rank : 309)	NC score	0.865268 (rank : 229)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	747
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MARK3_HUMAN
θ value	4.59992e-12 (rank : 310)	NC score	0.873849 (rank : 169)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	759
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PDPK1_HUMAN
θ value	4.59992e-12 (rank : 311)	NC score	0.866672 (rank : 217)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	751
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

CDK6_HUMAN
θ value	6.00763e-12 (rank : 312)	NC score	0.847442 (rank : 334)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDKL4_MOUSE
θ value	6.00763e-12 (rank : 313)	NC score	0.863224 (rank : 249)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KS6A4_MOUSE
θ value	6.00763e-12 (rank : 314)	NC score	0.841190 (rank : 375)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

LYN_MOUSE
θ value	6.00763e-12 (rank : 315)	NC score	0.768884 (rank : 576)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	767
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PMYT1_MOUSE
θ value	6.00763e-12 (rank : 316)	NC score	0.872690 (rank : 173)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	764
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

RIPK2_HUMAN
θ value	6.00763e-12 (rank : 317)	NC score	0.825814 (rank : 455)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

CD2L5_HUMAN
θ value	7.84624e-12 (rank : 318)	NC score	0.843645 (rank : 363)
Query Neighborhood Hits	1407	Target Neighborhood Hits	987	Shared Neighborhood Hits	777
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	7.84624e-12 (rank : 319)	NC score	0.843640 (rank : 364)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1011	Shared Neighborhood Hits	785
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDK2_HUMAN
θ value	7.84624e-12 (rank : 320)	NC score	0.856263 (rank : 281)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	749
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CHK2_MOUSE
θ value	7.84624e-12 (rank : 321)	NC score	0.870034 (rank : 195)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KPCE_MOUSE
θ value	7.84624e-12 (rank : 322)	NC score	0.836403 (rank : 401)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KS6B2_HUMAN
θ value	7.84624e-12 (rank : 323)	NC score	0.849424 (rank : 320)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

OBSCN_HUMAN
θ value	7.84624e-12 (rank : 324)	NC score	0.772422 (rank : 567)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1931	Shared Neighborhood Hits	922
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PCTK2_HUMAN
θ value	7.84624e-12 (rank : 325)	NC score	0.845897 (rank : 351)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	7.84624e-12 (rank : 326)	NC score	0.845802 (rank : 352)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	746
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	7.84624e-12 (rank : 327)	NC score	0.845491 (rank : 355)
Query Neighborhood Hits	1407	Target Neighborhood Hits	827	Shared Neighborhood Hits	744
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDPK1_MOUSE
θ value	7.84624e-12 (rank : 328)	NC score	0.866391 (rank : 218)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	749
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

CDKL2_HUMAN
θ value	1.02475e-11 (rank : 329)	NC score	0.859318 (rank : 269)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	746
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CHK2_HUMAN
θ value	1.02475e-11 (rank : 330)	NC score	0.868679 (rank : 203)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	743
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

ERN1_MOUSE
θ value	1.02475e-11 (rank : 331)	NC score	0.854817 (rank : 294)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	735
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M4K4_MOUSE
θ value	1.02475e-11 (rank : 332)	NC score	0.861531 (rank : 256)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1560	Shared Neighborhood Hits	802
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

RK_MOUSE
θ value	1.02475e-11 (rank : 333)	NC score	0.847000 (rank : 339)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

SPEG_MOUSE
θ value	1.02475e-11 (rank : 334)	NC score	0.794083 (rank : 524)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1022
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ANKK1_MOUSE
θ value	1.33837e-11 (rank : 335)	NC score	0.684200 (rank : 749)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1072	Shared Neighborhood Hits	741
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

KPCE_HUMAN
θ value	1.33837e-11 (rank : 336)	NC score	0.835886 (rank : 405)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

LRRK2_HUMAN
θ value	1.33837e-11 (rank : 337)	NC score	0.764603 (rank : 593)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1382	Shared Neighborhood Hits	748
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LYN_HUMAN
θ value	1.33837e-11 (rank : 338)	NC score	0.768575 (rank : 578)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1022	Shared Neighborhood Hits	765
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYLK2_HUMAN
θ value	1.33837e-11 (rank : 339)	NC score	0.872693 (rank : 172)
Query Neighborhood Hits	1407	Target Neighborhood Hits	920	Shared Neighborhood Hits	772
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PMYT1_HUMAN
θ value	1.33837e-11 (rank : 340)	NC score	0.867563 (rank : 212)
Query Neighborhood Hits	1407	Target Neighborhood Hits	814	Shared Neighborhood Hits	734
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

SPEG_HUMAN
θ value	1.33837e-11 (rank : 341)	NC score	0.798786 (rank : 518)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1762	Shared Neighborhood Hits	979
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

YES_HUMAN
θ value	1.33837e-11 (rank : 342)	NC score	0.746340 (rank : 635)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1059	Shared Neighborhood Hits	756
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	1.33837e-11 (rank : 343)	NC score	0.745870 (rank : 636)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1052	Shared Neighborhood Hits	754
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PRKX_MOUSE
θ value	1.74796e-11 (rank : 344)	NC score	0.855052 (rank : 289)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

ST32A_HUMAN
θ value	1.74796e-11 (rank : 345)	NC score	0.861980 (rank : 255)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	741
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

FRK_HUMAN
θ value	2.28291e-11 (rank : 346)	NC score	0.769511 (rank : 573)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	767
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MAST1_MOUSE
θ value	2.28291e-11 (rank : 347)	NC score	0.830846 (rank : 436)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	820
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

FAK2_MOUSE
θ value	2.98157e-11 (rank : 348)	NC score	0.768867 (rank : 577)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	738
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ICK_HUMAN
θ value	2.98157e-11 (rank : 349)	NC score	0.847922 (rank : 331)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	751
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	2.98157e-11 (rank : 350)	NC score	0.848905 (rank : 323)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	751
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KPCI_HUMAN
θ value	2.98157e-11 (rank : 351)	NC score	0.836736 (rank : 396)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	751
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	2.98157e-11 (rank : 352)	NC score	0.836528 (rank : 398)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	751
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MAST1_HUMAN
θ value	2.98157e-11 (rank : 353)	NC score	0.831350 (rank : 433)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1146	Shared Neighborhood Hits	830
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	2.98157e-11 (rank : 354)	NC score	0.833582 (rank : 423)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1189	Shared Neighborhood Hits	830
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	2.98157e-11 (rank : 355)	NC score	0.834442 (rank : 413)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1110	Shared Neighborhood Hits	803
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST4_HUMAN
θ value	2.98157e-11 (rank : 356)	NC score	0.830025 (rank : 438)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1804	Shared Neighborhood Hits	979
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MK13_MOUSE
θ value	2.98157e-11 (rank : 357)	NC score	0.833223 (rank : 425)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	745
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

PTK6_MOUSE
θ value	2.98157e-11 (rank : 358)	NC score	0.779682 (rank : 547)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	757
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RIPK5_HUMAN
θ value	2.98157e-11 (rank : 359)	NC score	0.855003 (rank : 290)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	754
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	2.98157e-11 (rank : 360)	NC score	0.854949 (rank : 291)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

HCK_HUMAN
θ value	3.89403e-11 (rank : 361)	NC score	0.751226 (rank : 616)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1035	Shared Neighborhood Hits	763
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KS6B2_MOUSE
θ value	3.89403e-11 (rank : 362)	NC score	0.846854 (rank : 341)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	768
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

LCK_MOUSE
θ value	3.89403e-11 (rank : 363)	NC score	0.763380 (rank : 595)
Query Neighborhood Hits	1407	Target Neighborhood Hits	981	Shared Neighborhood Hits	756
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MAK_MOUSE
θ value	3.89403e-11 (rank : 364)	NC score	0.846792 (rank : 342)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAPK3_MOUSE
θ value	3.89403e-11 (rank : 365)	NC score	0.842855 (rank : 367)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAST3_HUMAN
θ value	3.89403e-11 (rank : 366)	NC score	0.838511 (rank : 385)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1128	Shared Neighborhood Hits	846
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MK13_HUMAN
θ value	3.89403e-11 (rank : 367)	NC score	0.832797 (rank : 428)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	745
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

TSSK4_MOUSE
θ value	3.89403e-11 (rank : 368)	NC score	0.882487 (rank : 119)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	745
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TXK_HUMAN
θ value	3.89403e-11 (rank : 369)	NC score	0.776076 (rank : 558)
Query Neighborhood Hits	1407	Target Neighborhood Hits	971	Shared Neighborhood Hits	741
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BTK_HUMAN
θ value	5.08577e-11 (rank : 370)	NC score	0.765647 (rank : 588)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	746
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DCAK3_MOUSE
θ value	5.08577e-11 (rank : 371)	NC score	0.869668 (rank : 199)
Query Neighborhood Hits	1407	Target Neighborhood Hits	922	Shared Neighborhood Hits	753
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

GAK_HUMAN
θ value	5.08577e-11 (rank : 372)	NC score	0.833020 (rank : 426)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1028	Shared Neighborhood Hits	794
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MK14_HUMAN
θ value	5.08577e-11 (rank : 373)	NC score	0.835548 (rank : 408)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	749
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

PHKG1_MOUSE
θ value	5.08577e-11 (rank : 374)	NC score	0.869443 (rank : 201)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	747
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ST32A_MOUSE
θ value	5.08577e-11 (rank : 375)	NC score	0.863780 (rank : 244)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

TSSK4_HUMAN
θ value	5.08577e-11 (rank : 376)	NC score	0.882129 (rank : 123)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	747
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

BLK_HUMAN
θ value	6.64225e-11 (rank : 377)	NC score	0.758915 (rank : 603)
Query Neighborhood Hits	1407	Target Neighborhood Hits	994	Shared Neighborhood Hits	758
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CDK2_MOUSE
θ value	6.64225e-11 (rank : 378)	NC score	0.856014 (rank : 283)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	745
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

DCAK1_HUMAN
θ value	6.64225e-11 (rank : 379)	NC score	0.856114 (rank : 282)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	751
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DYR1B_MOUSE
θ value	6.64225e-11 (rank : 380)	NC score	0.780020 (rank : 546)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	711
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

KGP1A_HUMAN
θ value	6.64225e-11 (rank : 381)	NC score	0.834279 (rank : 414)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	747
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	6.64225e-11 (rank : 382)	NC score	0.833792 (rank : 421)
Query Neighborhood Hits	1407	Target Neighborhood Hits	921	Shared Neighborhood Hits	748
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	6.64225e-11 (rank : 383)	NC score	0.833835 (rank : 419)
Query Neighborhood Hits	1407	Target Neighborhood Hits	922	Shared Neighborhood Hits	748
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KPCG_MOUSE
θ value	6.64225e-11 (rank : 384)	NC score	0.809439 (rank : 501)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	750
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A5_HUMAN
θ value	6.64225e-11 (rank : 385)	NC score	0.841619 (rank : 372)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	752
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KSYK_MOUSE
θ value	6.64225e-11 (rank : 386)	NC score	0.766266 (rank : 584)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	755
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LRRK2_MOUSE
θ value	6.64225e-11 (rank : 387)	NC score	0.749696 (rank : 621)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1359	Shared Neighborhood Hits	746
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

M3K14_HUMAN
θ value	6.64225e-11 (rank : 388)	NC score	0.878107 (rank : 148)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	768
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MELK_MOUSE
θ value	6.64225e-11 (rank : 389)	NC score	0.859646 (rank : 267)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	752
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

RIPK4_HUMAN
θ value	6.64225e-11 (rank : 390)	NC score	0.679239 (rank : 754)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1094	Shared Neighborhood Hits	749
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TEC_MOUSE
θ value	6.64225e-11 (rank : 391)	NC score	0.778436 (rank : 553)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1006	Shared Neighborhood Hits	745
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_MOUSE
θ value	6.64225e-11 (rank : 392)	NC score	0.769341 (rank : 574)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	743
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CDKL4_HUMAN
θ value	8.67504e-11 (rank : 393)	NC score	0.860282 (rank : 264)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	742
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

FAK2_HUMAN
θ value	8.67504e-11 (rank : 394)	NC score	0.765287 (rank : 592)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	737
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

KS6A4_HUMAN
θ value	8.67504e-11 (rank : 395)	NC score	0.840003 (rank : 379)
Query Neighborhood Hits	1407	Target Neighborhood Hits	868	Shared Neighborhood Hits	760
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

SRMS_MOUSE
θ value	8.67504e-11 (rank : 396)	NC score	0.766814 (rank : 581)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	755
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ABL1_HUMAN
θ value	1.133e-10 (rank : 397)	NC score	0.771806 (rank : 570)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1220	Shared Neighborhood Hits	827
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	1.133e-10 (rank : 398)	NC score	0.773880 (rank : 564)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1178	Shared Neighborhood Hits	830
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

KPCT_HUMAN
θ value	1.133e-10 (rank : 399)	NC score	0.843809 (rank : 362)
Query Neighborhood Hits	1407	Target Neighborhood Hits	897	Shared Neighborhood Hits	756
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MAK_HUMAN
θ value	1.133e-10 (rank : 400)	NC score	0.844450 (rank : 358)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

TEC_HUMAN
θ value	1.133e-10 (rank : 401)	NC score	0.774889 (rank : 562)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1006	Shared Neighborhood Hits	747
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TOPK_HUMAN
θ value	1.133e-10 (rank : 402)	NC score	0.739155 (rank : 648)
Query Neighborhood Hits	1407	Target Neighborhood Hits	605	Shared Neighborhood Hits	549
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

BTK_MOUSE
θ value	1.47974e-10 (rank : 403)	NC score	0.765486 (rank : 590)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1017	Shared Neighborhood Hits	746
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CD2L7_HUMAN
θ value	1.47974e-10 (rank : 404)	NC score	0.848278 (rank : 328)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1275	Shared Neighborhood Hits	912
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CHK1_HUMAN
θ value	1.47974e-10 (rank : 405)	NC score	0.884394 (rank : 108)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	746
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	1.47974e-10 (rank : 406)	NC score	0.884460 (rank : 106)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	747
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

E2AK1_HUMAN
θ value	1.47974e-10 (rank : 407)	NC score	0.864642 (rank : 236)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	739
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

KPCA_HUMAN
θ value	1.47974e-10 (rank : 408)	NC score	0.818028 (rank : 478)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1070	Shared Neighborhood Hits	751
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCG_HUMAN
θ value	1.47974e-10 (rank : 409)	NC score	0.808521 (rank : 506)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1126	Shared Neighborhood Hits	750
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MK14_MOUSE
θ value	1.47974e-10 (rank : 410)	NC score	0.835279 (rank : 409)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	749
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

PCTK1_MOUSE
θ value	1.47974e-10 (rank : 411)	NC score	0.846081 (rank : 348)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	746
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

TSSK1_HUMAN
θ value	1.47974e-10 (rank : 412)	NC score	0.864899 (rank : 232)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	738
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	1.47974e-10 (rank : 413)	NC score	0.870496 (rank : 188)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	741
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DYR1B_HUMAN
θ value	1.9326e-10 (rank : 414)	NC score	0.778340 (rank : 554)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	723
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

E2AK4_MOUSE
θ value	1.9326e-10 (rank : 415)	NC score	0.857846 (rank : 276)
Query Neighborhood Hits	1407	Target Neighborhood Hits	984	Shared Neighborhood Hits	763
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

LCK_HUMAN
θ value	1.9326e-10 (rank : 416)	NC score	0.757266 (rank : 604)
Query Neighborhood Hits	1407	Target Neighborhood Hits	987	Shared Neighborhood Hits	759
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PCTK1_HUMAN
θ value	1.9326e-10 (rank : 417)	NC score	0.845935 (rank : 350)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	748
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PDK1L_HUMAN
θ value	1.9326e-10 (rank : 418)	NC score	0.877930 (rank : 149)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	743
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	1.9326e-10 (rank : 419)	NC score	0.877443 (rank : 154)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	743
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

SGK2_HUMAN
θ value	1.9326e-10 (rank : 420)	NC score	0.848189 (rank : 330)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

EPHA3_MOUSE
θ value	2.52405e-10 (rank : 421)	NC score	0.728444 (rank : 666)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	763
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ST32B_HUMAN
θ value	2.52405e-10 (rank : 422)	NC score	0.857644 (rank : 277)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	741
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

CAMKV_HUMAN
θ value	3.29651e-10 (rank : 423)	NC score	0.829632 (rank : 439)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1084	Shared Neighborhood Hits	788
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	3.29651e-10 (rank : 424)	NC score	0.832017 (rank : 431)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CD2L6_HUMAN
θ value	3.29651e-10 (rank : 425)	NC score	0.827854 (rank : 448)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	738
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	3.29651e-10 (rank : 426)	NC score	0.827886 (rank : 447)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	733
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CDK8_HUMAN
θ value	3.29651e-10 (rank : 427)	NC score	0.823099 (rank : 460)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	734
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

FYN_HUMAN
θ value	3.29651e-10 (rank : 428)	NC score	0.751079 (rank : 617)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1078	Shared Neighborhood Hits	763
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	3.29651e-10 (rank : 429)	NC score	0.750144 (rank : 619)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1073	Shared Neighborhood Hits	763
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

M3K14_MOUSE
θ value	3.29651e-10 (rank : 430)	NC score	0.872557 (rank : 176)
Query Neighborhood Hits	1407	Target Neighborhood Hits	889	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MK12_MOUSE
θ value	3.29651e-10 (rank : 431)	NC score	0.837324 (rank : 393)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MLKL_HUMAN
θ value	3.29651e-10 (rank : 432)	NC score	0.697397 (rank : 733)
Query Neighborhood Hits	1407	Target Neighborhood Hits	600	Shared Neighborhood Hits	541
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ST32B_MOUSE
θ value	3.29651e-10 (rank : 433)	NC score	0.858871 (rank : 272)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	740
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

TOPK_MOUSE
θ value	3.29651e-10 (rank : 434)	NC score	0.742768 (rank : 640)
Query Neighborhood Hits	1407	Target Neighborhood Hits	618	Shared Neighborhood Hits	563
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TYK2_HUMAN
θ value	3.29651e-10 (rank : 435)	NC score	0.802417 (rank : 516)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	745
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

EPHA3_HUMAN
θ value	4.30538e-10 (rank : 436)	NC score	0.734172 (rank : 654)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1005	Shared Neighborhood Hits	763
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

FAK1_HUMAN
θ value	4.30538e-10 (rank : 437)	NC score	0.779463 (rank : 548)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	751
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

HCK_MOUSE
θ value	4.30538e-10 (rank : 438)	NC score	0.752639 (rank : 614)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1029	Shared Neighborhood Hits	762
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KPCB_HUMAN
θ value	4.30538e-10 (rank : 439)	NC score	0.807945 (rank : 507)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1121	Shared Neighborhood Hits	753
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	4.30538e-10 (rank : 440)	NC score	0.808792 (rank : 504)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1117	Shared Neighborhood Hits	753
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPSH2_HUMAN
θ value	4.30538e-10 (rank : 441)	NC score	0.862023 (rank : 254)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	731
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

PKN2_HUMAN
θ value	4.30538e-10 (rank : 442)	NC score	0.842219 (rank : 368)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	745
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	4.30538e-10 (rank : 443)	NC score	0.842084 (rank : 370)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	745
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

ARBK2_HUMAN
θ value	5.62301e-10 (rank : 444)	NC score	0.826652 (rank : 452)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	737
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

BLK_MOUSE
θ value	5.62301e-10 (rank : 445)	NC score	0.755431 (rank : 606)
Query Neighborhood Hits	1407	Target Neighborhood Hits	992	Shared Neighborhood Hits	759
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CDK7_HUMAN
θ value	5.62301e-10 (rank : 446)	NC score	0.851961 (rank : 304)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	747
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	5.62301e-10 (rank : 447)	NC score	0.852574 (rank : 303)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

EPHB3_HUMAN
θ value	5.62301e-10 (rank : 448)	NC score	0.716543 (rank : 695)
Query Neighborhood Hits	1407	Target Neighborhood Hits	996	Shared Neighborhood Hits	756
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

JAK1_HUMAN
θ value	5.62301e-10 (rank : 449)	NC score	0.792467 (rank : 528)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	745
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KPCA_MOUSE
θ value	5.62301e-10 (rank : 450)	NC score	0.819463 (rank : 473)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1067	Shared Neighborhood Hits	748
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KSR2_HUMAN
θ value	5.62301e-10 (rank : 451)	NC score	0.854747 (rank : 295)
Query Neighborhood Hits	1407	Target Neighborhood Hits	920	Shared Neighborhood Hits	777
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

TRIO_HUMAN
θ value	5.62301e-10 (rank : 452)	NC score	0.780720 (rank : 545)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1580	Shared Neighborhood Hits	814
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CDKL1_HUMAN
θ value	7.34386e-10 (rank : 453)	NC score	0.854899 (rank : 292)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	745
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

SGK2_MOUSE
θ value	7.34386e-10 (rank : 454)	NC score	0.850312 (rank : 314)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	747
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDKL1_MOUSE
θ value	9.59137e-10 (rank : 455)	NC score	0.855197 (rank : 288)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

EPHB4_HUMAN
θ value	9.59137e-10 (rank : 456)	NC score	0.728932 (rank : 664)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	757
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	9.59137e-10 (rank : 457)	NC score	0.732318 (rank : 659)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1013	Shared Neighborhood Hits	754
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

JAK1_MOUSE
θ value	9.59137e-10 (rank : 458)	NC score	0.787331 (rank : 537)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	744
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MAPK2_HUMAN
θ value	9.59137e-10 (rank : 459)	NC score	0.847118 (rank : 338)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	739
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MK12_HUMAN
θ value	9.59137e-10 (rank : 460)	NC score	0.836348 (rank : 402)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	746
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PKN3_HUMAN
θ value	9.59137e-10 (rank : 461)	NC score	0.836577 (rank : 397)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	765
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

SRMS_HUMAN
θ value	9.59137e-10 (rank : 462)	NC score	0.761040 (rank : 602)
Query Neighborhood Hits	1407	Target Neighborhood Hits	946	Shared Neighborhood Hits	755
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

KPCL_HUMAN
θ value	1.25267e-09 (rank : 463)	NC score	0.829025 (rank : 444)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	745
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_MOUSE
θ value	1.25267e-09 (rank : 464)	NC score	0.832801 (rank : 427)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	745
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

BMPR2_MOUSE
θ value	1.63604e-09 (rank : 465)	NC score	0.742414 (rank : 643)
Query Neighborhood Hits	1407	Target Neighborhood Hits	738	Shared Neighborhood Hits	665
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ERBB2_HUMAN
θ value	1.63604e-09 (rank : 466)	NC score	0.733006 (rank : 658)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1073	Shared Neighborhood Hits	799
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	1.63604e-09 (rank : 467)	NC score	0.734571 (rank : 653)
Query Neighborhood Hits	1407	Target Neighborhood Hits	918	Shared Neighborhood Hits	752
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

IKKE_MOUSE
θ value	1.63604e-09 (rank : 468)	NC score	0.878523 (rank : 147)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	739
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MAPK2_MOUSE
θ value	1.63604e-09 (rank : 469)	NC score	0.844700 (rank : 357)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	729
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MK11_MOUSE
θ value	1.63604e-09 (rank : 470)	NC score	0.829184 (rank : 443)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

TGFR2_HUMAN
θ value	1.63604e-09 (rank : 471)	NC score	0.775235 (rank : 560)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	694
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ARBK1_MOUSE
θ value	2.13673e-09 (rank : 472)	NC score	0.826606 (rank : 453)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	740
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CDK3_MOUSE
θ value	2.13673e-09 (rank : 473)	NC score	0.863729 (rank : 246)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

EPHB3_MOUSE
θ value	2.13673e-09 (rank : 474)	NC score	0.714893 (rank : 701)
Query Neighborhood Hits	1407	Target Neighborhood Hits	996	Shared Neighborhood Hits	755
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

IGF1R_HUMAN
θ value	2.13673e-09 (rank : 475)	NC score	0.702709 (rank : 720)
Query Neighborhood Hits	1407	Target Neighborhood Hits	977	Shared Neighborhood Hits	734
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

KPCD_HUMAN
θ value	2.13673e-09 (rank : 476)	NC score	0.832437 (rank : 429)
Query Neighborhood Hits	1407	Target Neighborhood Hits	900	Shared Neighborhood Hits	748
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KSYK_HUMAN
θ value	2.13673e-09 (rank : 477)	NC score	0.765474 (rank : 591)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	743
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MAPK3_HUMAN
θ value	2.13673e-09 (rank : 478)	NC score	0.838453 (rank : 386)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	710
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MK15_MOUSE
θ value	2.13673e-09 (rank : 479)	NC score	0.828480 (rank : 445)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	750
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

STK35_HUMAN
θ value	2.13673e-09 (rank : 480)	NC score	0.872646 (rank : 174)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	738
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TESK2_MOUSE
θ value	2.13673e-09 (rank : 481)	NC score	0.864928 (rank : 231)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TGFR2_MOUSE
θ value	2.13673e-09 (rank : 482)	NC score	0.776129 (rank : 557)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	695
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ARBK1_HUMAN
θ value	2.79066e-09 (rank : 483)	NC score	0.828099 (rank : 446)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	741
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

BMPR2_HUMAN
θ value	2.79066e-09 (rank : 484)	NC score	0.742735 (rank : 641)
Query Neighborhood Hits	1407	Target Neighborhood Hits	736	Shared Neighborhood Hits	663
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

FGR_MOUSE
θ value	2.79066e-09 (rank : 485)	NC score	0.730735 (rank : 661)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	761
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

IKKE_HUMAN
θ value	2.79066e-09 (rank : 486)	NC score	0.878871 (rank : 144)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	736
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ST38L_HUMAN
θ value	2.79066e-09 (rank : 487)	NC score	0.811670 (rank : 497)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	718
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	2.79066e-09 (rank : 488)	NC score	0.802666 (rank : 515)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	712
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TESK2_HUMAN
θ value	2.79066e-09 (rank : 489)	NC score	0.864012 (rank : 242)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	745
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ANKK1_HUMAN
θ value	3.64472e-09 (rank : 490)	NC score	0.673140 (rank : 758)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1075	Shared Neighborhood Hits	738
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

CCRK_MOUSE
θ value	3.64472e-09 (rank : 491)	NC score	0.837750 (rank : 390)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	743
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CDK9_MOUSE
θ value	3.64472e-09 (rank : 492)	NC score	0.843153 (rank : 366)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	743
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

E2AK1_MOUSE
θ value	3.64472e-09 (rank : 493)	NC score	0.864294 (rank : 238)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	738
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

IGF1R_MOUSE
θ value	3.64472e-09 (rank : 494)	NC score	0.703378 (rank : 717)
Query Neighborhood Hits	1407	Target Neighborhood Hits	973	Shared Neighborhood Hits	735
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSR_HUMAN
θ value	3.64472e-09 (rank : 495)	NC score	0.718403 (rank : 687)
Query Neighborhood Hits	1407	Target Neighborhood Hits	963	Shared Neighborhood Hits	748
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MK15_HUMAN
θ value	3.64472e-09 (rank : 496)	NC score	0.835708 (rank : 407)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1038	Shared Neighborhood Hits	806
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PKN1_MOUSE
θ value	3.64472e-09 (rank : 497)	NC score	0.838661 (rank : 384)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	749
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN3_MOUSE
θ value	3.64472e-09 (rank : 498)	NC score	0.835800 (rank : 406)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	789
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ABL2_HUMAN
θ value	4.76016e-09 (rank : 499)	NC score	0.766901 (rank : 580)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1045	Shared Neighborhood Hits	762
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

EPHA7_MOUSE
θ value	4.76016e-09 (rank : 500)	NC score	0.725930 (rank : 671)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1025	Shared Neighborhood Hits	756
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

GRK7_HUMAN
θ value	4.76016e-09 (rank : 501)	NC score	0.833713 (rank : 422)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	741
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KPCD_MOUSE
θ value	4.76016e-09 (rank : 502)	NC score	0.829217 (rank : 442)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	744
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MAGE1_HUMAN
θ value	4.76016e-09 (rank : 503)	NC score	0.080548 (rank : 928)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1389	Shared Neighborhood Hits	378
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MK03_HUMAN
θ value	4.76016e-09 (rank : 504)	NC score	0.830861 (rank : 435)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

PKN1_HUMAN
θ value	4.76016e-09 (rank : 505)	NC score	0.838410 (rank : 387)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	757
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

RIPK1_HUMAN
θ value	4.76016e-09 (rank : 506)	NC score	0.854506 (rank : 296)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	757
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TSSK3_MOUSE
θ value	4.76016e-09 (rank : 507)	NC score	0.864410 (rank : 237)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	723
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

EPHA2_HUMAN
θ value	6.21693e-09 (rank : 508)	NC score	0.728957 (rank : 663)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1021	Shared Neighborhood Hits	759
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

IRAK1_MOUSE
θ value	6.21693e-09 (rank : 509)	NC score	0.806936 (rank : 509)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	706
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

KS6B1_HUMAN
θ value	6.21693e-09 (rank : 510)	NC score	0.845719 (rank : 353)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	747
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	6.21693e-09 (rank : 511)	NC score	0.845715 (rank : 354)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

MRCKG_HUMAN
θ value	6.21693e-09 (rank : 512)	NC score	0.789166 (rank : 532)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1519	Shared Neighborhood Hits	789
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

TSSK3_HUMAN
θ value	6.21693e-09 (rank : 513)	NC score	0.863736 (rank : 245)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	723
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

AVR2A_HUMAN
θ value	8.11959e-09 (rank : 514)	NC score	0.776748 (rank : 556)
Query Neighborhood Hits	1407	Target Neighborhood Hits	767	Shared Neighborhood Hits	710
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	8.11959e-09 (rank : 515)	NC score	0.776761 (rank : 555)
Query Neighborhood Hits	1407	Target Neighborhood Hits	767	Shared Neighborhood Hits	710
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

EPHA7_HUMAN
θ value	8.11959e-09 (rank : 516)	NC score	0.724420 (rank : 675)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1053	Shared Neighborhood Hits	760
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

ERN2_HUMAN
θ value	8.11959e-09 (rank : 517)	NC score	0.843939 (rank : 361)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	737
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MKNK1_MOUSE
θ value	8.11959e-09 (rank : 518)	NC score	0.833332 (rank : 424)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	720
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MRCKA_HUMAN
θ value	8.11959e-09 (rank : 519)	NC score	0.737626 (rank : 649)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1999	Shared Neighborhood Hits	800
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

RIPK3_HUMAN
θ value	8.11959e-09 (rank : 520)	NC score	0.850681 (rank : 311)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	743
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

CDK9_HUMAN
θ value	1.06045e-08 (rank : 521)	NC score	0.843326 (rank : 365)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	743
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

EPHA5_MOUSE
θ value	1.06045e-08 (rank : 522)	NC score	0.747084 (rank : 633)
Query Neighborhood Hits	1407	Target Neighborhood Hits	950	Shared Neighborhood Hits	754
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ERBB3_MOUSE
θ value	1.06045e-08 (rank : 523)	NC score	0.713749 (rank : 702)
Query Neighborhood Hits	1407	Target Neighborhood Hits	898	Shared Neighborhood Hits	729
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

FGR_HUMAN
θ value	1.06045e-08 (rank : 524)	NC score	0.733852 (rank : 656)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1067	Shared Neighborhood Hits	762
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GSK3A_HUMAN
θ value	1.06045e-08 (rank : 525)	NC score	0.827282 (rank : 450)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	735
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

ST32C_MOUSE
θ value	1.06045e-08 (rank : 526)	NC score	0.853781 (rank : 299)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	738
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

EPHA5_HUMAN
θ value	1.38499e-08 (rank : 527)	NC score	0.728611 (rank : 665)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	759
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB2_HUMAN
θ value	1.38499e-08 (rank : 528)	NC score	0.724408 (rank : 676)
Query Neighborhood Hits	1407	Target Neighborhood Hits	983	Shared Neighborhood Hits	751
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	1.38499e-08 (rank : 529)	NC score	0.724495 (rank : 674)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	751
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

KS6A5_MOUSE
θ value	1.38499e-08 (rank : 530)	NC score	0.836275 (rank : 403)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	750
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MK03_MOUSE
θ value	1.38499e-08 (rank : 531)	NC score	0.830056 (rank : 437)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MRCKG_MOUSE
θ value	1.38499e-08 (rank : 532)	NC score	0.785007 (rank : 541)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1466	Shared Neighborhood Hits	769
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

DYR1A_HUMAN
θ value	1.80886e-08 (rank : 533)	NC score	0.766020 (rank : 587)
Query Neighborhood Hits	1407	Target Neighborhood Hits	764	Shared Neighborhood Hits	687
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	1.80886e-08 (rank : 534)	NC score	0.766029 (rank : 586)
Query Neighborhood Hits	1407	Target Neighborhood Hits	762	Shared Neighborhood Hits	687
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

E2AK4_HUMAN
θ value	1.80886e-08 (rank : 535)	NC score	0.858989 (rank : 271)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1012	Shared Neighborhood Hits	766
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MKNK2_MOUSE
θ value	1.80886e-08 (rank : 536)	NC score	0.834058 (rank : 417)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	734
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PASK_HUMAN
θ value	1.80886e-08 (rank : 537)	NC score	0.861428 (rank : 257)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	741
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

AVR2B_HUMAN
θ value	2.36244e-08 (rank : 538)	NC score	0.762984 (rank : 599)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	695
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	2.36244e-08 (rank : 539)	NC score	0.763218 (rank : 598)
Query Neighborhood Hits	1407	Target Neighborhood Hits	749	Shared Neighborhood Hits	695
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

EPHA1_HUMAN
θ value	2.36244e-08 (rank : 540)	NC score	0.729545 (rank : 662)
Query Neighborhood Hits	1407	Target Neighborhood Hits	997	Shared Neighborhood Hits	754
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

FES_MOUSE
θ value	2.36244e-08 (rank : 541)	NC score	0.787667 (rank : 535)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	756
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

M3K8_HUMAN
θ value	2.36244e-08 (rank : 542)	NC score	0.870656 (rank : 185)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	720
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MK04_MOUSE
θ value	2.36244e-08 (rank : 543)	NC score	0.826973 (rank : 451)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	741
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MRCKB_MOUSE
θ value	2.36244e-08 (rank : 544)	NC score	0.724524 (rank : 673)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2180	Shared Neighborhood Hits	820
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PIM2_MOUSE
θ value	2.36244e-08 (rank : 545)	NC score	0.837439 (rank : 392)
Query Neighborhood Hits	1407	Target Neighborhood Hits	809	Shared Neighborhood Hits	726
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

BMR1A_HUMAN
θ value	3.08544e-08 (rank : 546)	NC score	0.753681 (rank : 610)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	698
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	3.08544e-08 (rank : 547)	NC score	0.752699 (rank : 613)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	699
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

E2AK3_MOUSE
θ value	3.08544e-08 (rank : 548)	NC score	0.850754 (rank : 310)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

FES_HUMAN
θ value	3.08544e-08 (rank : 549)	NC score	0.787342 (rank : 536)
Query Neighborhood Hits	1407	Target Neighborhood Hits	978	Shared Neighborhood Hits	749
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

INSR_MOUSE
θ value	3.08544e-08 (rank : 550)	NC score	0.715464 (rank : 700)
Query Neighborhood Hits	1407	Target Neighborhood Hits	968	Shared Neighborhood Hits	744
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MK07_HUMAN
θ value	3.08544e-08 (rank : 551)	NC score	0.840584 (rank : 377)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1087	Shared Neighborhood Hits	883
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK11_HUMAN
θ value	3.08544e-08 (rank : 552)	NC score	0.822858 (rank : 461)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	741
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MRCKB_HUMAN
θ value	3.08544e-08 (rank : 553)	NC score	0.717052 (rank : 691)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2239	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NTRK1_HUMAN
θ value	3.08544e-08 (rank : 554)	NC score	0.711357 (rank : 707)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	728
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SBK1_MOUSE
θ value	3.08544e-08 (rank : 555)	NC score	0.866275 (rank : 219)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	733
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ACVR1_HUMAN
θ value	4.0297e-08 (rank : 556)	NC score	0.763236 (rank : 597)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	706
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

CTRO_HUMAN
θ value	4.0297e-08 (rank : 557)	NC score	0.735643 (rank : 650)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2092	Shared Neighborhood Hits	819
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

INSRR_MOUSE
θ value	4.0297e-08 (rank : 558)	NC score	0.700784 (rank : 724)
Query Neighborhood Hits	1407	Target Neighborhood Hits	961	Shared Neighborhood Hits	727
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

MK04_HUMAN
θ value	4.0297e-08 (rank : 559)	NC score	0.829331 (rank : 441)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	740
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

NLK_HUMAN
θ value	4.0297e-08 (rank : 560)	NC score	0.833819 (rank : 420)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	4.0297e-08 (rank : 561)	NC score	0.833896 (rank : 418)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	748
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

IRAK1_HUMAN
θ value	5.26297e-08 (rank : 562)	NC score	0.809029 (rank : 503)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	723
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

ST32C_HUMAN
θ value	5.26297e-08 (rank : 563)	NC score	0.850834 (rank : 309)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	741
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

CCRK_HUMAN
θ value	6.87365e-08 (rank : 564)	NC score	0.837160 (rank : 394)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	744
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

EPHA1_MOUSE
θ value	6.87365e-08 (rank : 565)	NC score	0.718709 (rank : 685)
Query Neighborhood Hits	1407	Target Neighborhood Hits	958	Shared Neighborhood Hits	742
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_MOUSE
θ value	6.87365e-08 (rank : 566)	NC score	0.722970 (rank : 678)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FAK1_MOUSE
θ value	6.87365e-08 (rank : 567)	NC score	0.778599 (rank : 552)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	747
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

M3K8_MOUSE
θ value	6.87365e-08 (rank : 568)	NC score	0.870269 (rank : 190)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	721
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MK07_MOUSE
θ value	6.87365e-08 (rank : 569)	NC score	0.839574 (rank : 381)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1054	Shared Neighborhood Hits	870
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PIM1_HUMAN
θ value	6.87365e-08 (rank : 570)	NC score	0.836474 (rank : 399)
Query Neighborhood Hits	1407	Target Neighborhood Hits	797	Shared Neighborhood Hits	719
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	6.87365e-08 (rank : 571)	NC score	0.834138 (rank : 415)
Query Neighborhood Hits	1407	Target Neighborhood Hits	787	Shared Neighborhood Hits	706
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TBK1_HUMAN
θ value	6.87365e-08 (rank : 572)	NC score	0.870076 (rank : 193)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	733
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

ACVL1_MOUSE
θ value	8.97725e-08 (rank : 573)	NC score	0.725868 (rank : 672)
Query Neighborhood Hits	1407	Target Neighborhood Hits	739	Shared Neighborhood Hits	690
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EPHA4_HUMAN
θ value	8.97725e-08 (rank : 574)	NC score	0.721682 (rank : 680)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	758
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	8.97725e-08 (rank : 575)	NC score	0.721474 (rank : 681)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	758
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

GSK3B_HUMAN
θ value	8.97725e-08 (rank : 576)	NC score	0.822693 (rank : 464)
Query Neighborhood Hits	1407	Target Neighborhood Hits	801	Shared Neighborhood Hits	720
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	8.97725e-08 (rank : 577)	NC score	0.822695 (rank : 463)
Query Neighborhood Hits	1407	Target Neighborhood Hits	800	Shared Neighborhood Hits	720
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

SBK1_HUMAN
θ value	8.97725e-08 (rank : 578)	NC score	0.863834 (rank : 243)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	734
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TBK1_MOUSE
θ value	8.97725e-08 (rank : 579)	NC score	0.869072 (rank : 202)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	734
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

BMR1B_HUMAN
θ value	1.17247e-07 (rank : 580)	NC score	0.743687 (rank : 638)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	696
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	1.17247e-07 (rank : 581)	NC score	0.744324 (rank : 637)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	696
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

KSR1_HUMAN
θ value	1.17247e-07 (rank : 582)	NC score	0.814124 (rank : 490)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	730
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TGFR1_HUMAN
θ value	1.17247e-07 (rank : 583)	NC score	0.748202 (rank : 627)
Query Neighborhood Hits	1407	Target Neighborhood Hits	755	Shared Neighborhood Hits	703
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	1.17247e-07 (rank : 584)	NC score	0.747670 (rank : 630)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	703
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TSSK6_MOUSE
θ value	1.17247e-07 (rank : 585)	NC score	0.863535 (rank : 247)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	735
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CD2L2_HUMAN
θ value	1.53129e-07 (rank : 586)	NC score	0.823848 (rank : 458)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1439	Shared Neighborhood Hits	791
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

KSR1_MOUSE
θ value	1.53129e-07 (rank : 587)	NC score	0.821974 (rank : 466)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	745
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

RIPK3_MOUSE
θ value	1.53129e-07 (rank : 588)	NC score	0.853438 (rank : 302)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	757
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

UFO_MOUSE
θ value	1.53129e-07 (rank : 589)	NC score	0.704118 (rank : 715)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	711
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ACV1B_HUMAN
θ value	1.99992e-07 (rank : 590)	NC score	0.742367 (rank : 644)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	707
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	1.99992e-07 (rank : 591)	NC score	0.742445 (rank : 642)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	706
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

AMHR2_HUMAN
θ value	1.99992e-07 (rank : 592)	NC score	0.662565 (rank : 763)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	636
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

MDC1_HUMAN
θ value	1.99992e-07 (rank : 593)	NC score	0.107205 (rank : 868)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1446	Shared Neighborhood Hits	341
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PASK_MOUSE
θ value	1.99992e-07 (rank : 594)	NC score	0.864862 (rank : 233)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	744
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

ROCK1_HUMAN
θ value	1.99992e-07 (rank : 595)	NC score	0.731859 (rank : 660)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2000	Shared Neighborhood Hits	805
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.99992e-07 (rank : 596)	NC score	0.717019 (rank : 692)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2126	Shared Neighborhood Hits	813
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROS_HUMAN
θ value	1.99992e-07 (rank : 597)	NC score	0.711474 (rank : 706)
Query Neighborhood Hits	1407	Target Neighborhood Hits	907	Shared Neighborhood Hits	716
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

SPR1B_MOUSE
θ value	1.99992e-07 (rank : 598)	NC score	0.064099 (rank : 1006)
Query Neighborhood Hits	1407	Target Neighborhood Hits	395	Shared Neighborhood Hits	135
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

TSSK6_HUMAN
θ value	1.99992e-07 (rank : 599)	NC score	0.863334 (rank : 248)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	736
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ACV1C_MOUSE
θ value	2.61198e-07 (rank : 600)	NC score	0.701083 (rank : 723)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	656
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CD2L1_HUMAN
θ value	2.61198e-07 (rank : 601)	NC score	0.821032 (rank : 469)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1467	Shared Neighborhood Hits	790
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

EPHA8_HUMAN
θ value	2.61198e-07 (rank : 602)	NC score	0.720246 (rank : 683)
Query Neighborhood Hits	1407	Target Neighborhood Hits	956	Shared Neighborhood Hits	752
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

MATK_MOUSE
θ value	2.61198e-07 (rank : 603)	NC score	0.766274 (rank : 583)
Query Neighborhood Hits	1407	Target Neighborhood Hits	952	Shared Neighborhood Hits	752
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MK06_HUMAN
θ value	2.61198e-07 (rank : 604)	NC score	0.813747 (rank : 491)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	716
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	2.61198e-07 (rank : 605)	NC score	0.813413 (rank : 492)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

STK38_HUMAN
θ value	2.61198e-07 (rank : 606)	NC score	0.810269 (rank : 500)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	723
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	2.61198e-07 (rank : 607)	NC score	0.810662 (rank : 499)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	723
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

UFO_HUMAN
θ value	2.61198e-07 (rank : 608)	NC score	0.700200 (rank : 727)
Query Neighborhood Hits	1407	Target Neighborhood Hits	981	Shared Neighborhood Hits	714
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ACVR1_MOUSE
θ value	3.41135e-07 (rank : 609)	NC score	0.765530 (rank : 589)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	712
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

CDKL5_HUMAN
θ value	3.41135e-07 (rank : 610)	NC score	0.844250 (rank : 359)
Query Neighborhood Hits	1407	Target Neighborhood Hits	967	Shared Neighborhood Hits	768
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KGP2_HUMAN
θ value	3.41135e-07 (rank : 611)	NC score	0.836881 (rank : 395)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	761
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	3.41135e-07 (rank : 612)	NC score	0.836460 (rank : 400)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1029	Shared Neighborhood Hits	757
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

LTK_HUMAN
θ value	3.41135e-07 (rank : 613)	NC score	0.674741 (rank : 757)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	689
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MKNK2_HUMAN
θ value	3.41135e-07 (rank : 614)	NC score	0.836140 (rank : 404)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	736
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

RGS3_MOUSE
θ value	3.41135e-07 (rank : 615)	NC score	0.085080 (rank : 918)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1621	Shared Neighborhood Hits	405
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ACV1C_HUMAN
θ value	4.45536e-07 (rank : 616)	NC score	0.697791 (rank : 731)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	652
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CD2L1_MOUSE
θ value	4.45536e-07 (rank : 617)	NC score	0.820461 (rank : 472)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1463	Shared Neighborhood Hits	790
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

MLKL_MOUSE
θ value	4.45536e-07 (rank : 618)	NC score	0.767021 (rank : 579)
Query Neighborhood Hits	1407	Target Neighborhood Hits	707	Shared Neighborhood Hits	651
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

AATK_MOUSE
θ value	5.81887e-07 (rank : 619)	NC score	0.715906 (rank : 699)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	768
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

CSK21_HUMAN
θ value	5.81887e-07 (rank : 620)	NC score	0.796579 (rank : 520)
Query Neighborhood Hits	1407	Target Neighborhood Hits	772	Shared Neighborhood Hits	693
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	5.81887e-07 (rank : 621)	NC score	0.797607 (rank : 519)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	693
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CTRO_MOUSE
θ value	5.81887e-07 (rank : 622)	NC score	0.717591 (rank : 689)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2344	Shared Neighborhood Hits	836
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

INSRR_HUMAN
θ value	5.81887e-07 (rank : 623)	NC score	0.697814 (rank : 730)
Query Neighborhood Hits	1407	Target Neighborhood Hits	950	Shared Neighborhood Hits	729
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

MOS_MOUSE
θ value	5.81887e-07 (rank : 624)	NC score	0.858581 (rank : 273)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ZAP70_HUMAN
θ value	5.81887e-07 (rank : 625)	NC score	0.770147 (rank : 572)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	743
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CSK22_MOUSE
θ value	7.59969e-07 (rank : 626)	NC score	0.789243 (rank : 531)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	683
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

EPHA8_MOUSE
θ value	7.59969e-07 (rank : 627)	NC score	0.715943 (rank : 698)
Query Neighborhood Hits	1407	Target Neighborhood Hits	969	Shared Neighborhood Hits	753
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

MERTK_MOUSE
θ value	7.59969e-07 (rank : 628)	NC score	0.691838 (rank : 737)
Query Neighborhood Hits	1407	Target Neighborhood Hits	974	Shared Neighborhood Hits	712
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MK09_MOUSE
θ value	7.59969e-07 (rank : 629)	NC score	0.818872 (rank : 474)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	747
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

NTRK3_HUMAN
θ value	7.59969e-07 (rank : 630)	NC score	0.701764 (rank : 722)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1115	Shared Neighborhood Hits	739
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PIM2_HUMAN
θ value	7.59969e-07 (rank : 631)	NC score	0.834990 (rank : 411)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	731
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

CSK22_HUMAN
θ value	9.92553e-07 (rank : 632)	NC score	0.788424 (rank : 533)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	683
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

RIPK1_MOUSE
θ value	9.92553e-07 (rank : 633)	NC score	0.849127 (rank : 322)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	757
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ROCK2_HUMAN
θ value	9.92553e-07 (rank : 634)	NC score	0.733546 (rank : 657)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2073	Shared Neighborhood Hits	800
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	9.92553e-07 (rank : 635)	NC score	0.727524 (rank : 670)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2072	Shared Neighborhood Hits	795
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

AL2S2_HUMAN
θ value	1.29631e-06 (rank : 636)	NC score	0.829381 (rank : 440)
Query Neighborhood Hits	1407	Target Neighborhood Hits	727	Shared Neighborhood Hits	668
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

NTRK2_MOUSE
θ value	1.29631e-06 (rank : 637)	NC score	0.727820 (rank : 667)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1088	Shared Neighborhood Hits	742
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ZAP70_MOUSE
θ value	1.29631e-06 (rank : 638)	NC score	0.766786 (rank : 582)
Query Neighborhood Hits	1407	Target Neighborhood Hits	905	Shared Neighborhood Hits	748
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

GRK4_HUMAN
θ value	1.69304e-06 (rank : 639)	NC score	0.817777 (rank : 479)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	734
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MASTL_HUMAN
θ value	1.69304e-06 (rank : 640)	NC score	0.841885 (rank : 371)
Query Neighborhood Hits	1407	Target Neighborhood Hits	894	Shared Neighborhood Hits	750
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PIM3_HUMAN
θ value	1.69304e-06 (rank : 641)	NC score	0.831016 (rank : 434)
Query Neighborhood Hits	1407	Target Neighborhood Hits	789	Shared Neighborhood Hits	719
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CDK10_HUMAN
θ value	2.21117e-06 (rank : 642)	NC score	0.838132 (rank : 388)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CSK_MOUSE
θ value	2.21117e-06 (rank : 643)	NC score	0.773300 (rank : 565)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	754
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

MK09_HUMAN
θ value	2.21117e-06 (rank : 644)	NC score	0.821147 (rank : 468)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

NTRK2_HUMAN
θ value	2.21117e-06 (rank : 645)	NC score	0.727642 (rank : 668)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1081	Shared Neighborhood Hits	742
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

WEE1B_MOUSE
θ value	2.21117e-06 (rank : 646)	NC score	0.814413 (rank : 489)
Query Neighborhood Hits	1407	Target Neighborhood Hits	765	Shared Neighborhood Hits	690
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

ACVL1_HUMAN
θ value	2.88788e-06 (rank : 647)	NC score	0.707267 (rank : 712)
Query Neighborhood Hits	1407	Target Neighborhood Hits	716	Shared Neighborhood Hits	666
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

AL2S2_MOUSE
θ value	2.88788e-06 (rank : 648)	NC score	0.818777 (rank : 477)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	651
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

MERTK_HUMAN
θ value	2.88788e-06 (rank : 649)	NC score	0.684205 (rank : 748)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	721
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PRAX_MOUSE
θ value	2.88788e-06 (rank : 650)	NC score	0.075611 (rank : 939)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	78
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

TNK1_HUMAN
θ value	2.88788e-06 (rank : 651)	NC score	0.749859 (rank : 620)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	740
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

WEE1_MOUSE
θ value	2.88788e-06 (rank : 652)	NC score	0.838671 (rank : 383)
Query Neighborhood Hits	1407	Target Neighborhood Hits	794	Shared Neighborhood Hits	701
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

E2AK3_HUMAN
θ value	3.77169e-06 (rank : 653)	NC score	0.847761 (rank : 332)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	743
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

MATK_HUMAN
θ value	3.77169e-06 (rank : 654)	NC score	0.762799 (rank : 601)
Query Neighborhood Hits	1407	Target Neighborhood Hits	954	Shared Neighborhood Hits	751
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MASTL_MOUSE
θ value	4.92598e-06 (rank : 655)	NC score	0.842206 (rank : 369)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	746
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

TYRO3_MOUSE
θ value	4.92598e-06 (rank : 656)	NC score	0.693096 (rank : 735)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1007	Shared Neighborhood Hits	726
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ANPRA_MOUSE
θ value	6.43352e-06 (rank : 657)	NC score	0.536714 (rank : 818)
Query Neighborhood Hits	1407	Target Neighborhood Hits	600	Shared Neighborhood Hits	507
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

EPHB6_MOUSE
θ value	6.43352e-06 (rank : 658)	NC score	0.625198 (rank : 798)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	679
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

LR37A_HUMAN
θ value	6.43352e-06 (rank : 659)	NC score	0.049489 (rank : 1130)
Query Neighborhood Hits	1407	Target Neighborhood Hits	720	Shared Neighborhood Hits	194
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LTK_MOUSE
θ value	6.43352e-06 (rank : 660)	NC score	0.675303 (rank : 756)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	691
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

CSK_HUMAN
θ value	8.40245e-06 (rank : 661)	NC score	0.766107 (rank : 585)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	754
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ERN2_MOUSE
θ value	8.40245e-06 (rank : 662)	NC score	0.839769 (rank : 380)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	729
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NACAM_MOUSE
θ value	8.40245e-06 (rank : 663)	NC score	0.125191 (rank : 858)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1866	Shared Neighborhood Hits	482
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PIM3_MOUSE
θ value	1.09739e-05 (rank : 664)	NC score	0.827591 (rank : 449)
Query Neighborhood Hits	1407	Target Neighborhood Hits	783	Shared Neighborhood Hits	712
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

MOK_HUMAN
θ value	1.43324e-05 (rank : 665)	NC score	0.806935 (rank : 510)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	718
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

TXND2_HUMAN
θ value	1.43324e-05 (rank : 666)	NC score	0.057138 (rank : 1053)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	189
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

K1802_MOUSE
θ value	1.87187e-05 (rank : 667)	NC score	0.056593 (rank : 1060)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1596	Shared Neighborhood Hits	350
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MKNK1_HUMAN
θ value	1.87187e-05 (rank : 668)	NC score	0.774174 (rank : 563)
Query Neighborhood Hits	1407	Target Neighborhood Hits	701	Shared Neighborhood Hits	629
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NFH_MOUSE
θ value	1.87187e-05 (rank : 669)	NC score	0.060977 (rank : 1027)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2247	Shared Neighborhood Hits	438
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PER2_MOUSE
θ value	1.87187e-05 (rank : 670)	NC score	0.037945 (rank : 1178)
Query Neighborhood Hits	1407	Target Neighborhood Hits	325	Shared Neighborhood Hits	108
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

TYRO3_HUMAN
θ value	1.87187e-05 (rank : 671)	NC score	0.693400 (rank : 734)
Query Neighborhood Hits	1407	Target Neighborhood Hits	995	Shared Neighborhood Hits	725
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

MK10_HUMAN
θ value	2.44474e-05 (rank : 672)	NC score	0.817388 (rank : 481)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	2.44474e-05 (rank : 673)	NC score	0.817325 (rank : 482)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	747
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

PTK7_HUMAN
θ value	2.44474e-05 (rank : 674)	NC score	0.662974 (rank : 762)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	729
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

RGS3_HUMAN
θ value	2.44474e-05 (rank : 675)	NC score	0.073708 (rank : 949)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1375	Shared Neighborhood Hits	337
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

DMPK_HUMAN
θ value	3.19293e-05 (rank : 676)	NC score	0.811155 (rank : 498)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	739
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

FGFR3_HUMAN
θ value	3.19293e-05 (rank : 677)	NC score	0.711585 (rank : 705)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1042	Shared Neighborhood Hits	747
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

MOK_MOUSE
θ value	3.19293e-05 (rank : 678)	NC score	0.803222 (rank : 514)
Query Neighborhood Hits	1407	Target Neighborhood Hits	796	Shared Neighborhood Hits	714
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

ACK1_MOUSE
θ value	4.1701e-05 (rank : 679)	NC score	0.746671 (rank : 634)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1080	Shared Neighborhood Hits	853
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

BMP2K_HUMAN
θ value	4.1701e-05 (rank : 680)	NC score	0.822004 (rank : 465)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	724
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

LATS2_HUMAN
θ value	4.1701e-05 (rank : 681)	NC score	0.789345 (rank : 530)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	760
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

WEE1B_HUMAN
θ value	4.1701e-05 (rank : 682)	NC score	0.818805 (rank : 476)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	696
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CD248_HUMAN
θ value	5.44631e-05 (rank : 683)	NC score	0.042730 (rank : 1151)
Query Neighborhood Hits	1407	Target Neighborhood Hits	679	Shared Neighborhood Hits	179
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

ILK1_HUMAN
θ value	5.44631e-05 (rank : 684)	NC score	0.523956 (rank : 829)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	552
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

MK08_HUMAN
θ value	5.44631e-05 (rank : 685)	NC score	0.815178 (rank : 487)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	5.44631e-05 (rank : 686)	NC score	0.815862 (rank : 486)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MOS_HUMAN
θ value	5.44631e-05 (rank : 687)	NC score	0.855833 (rank : 285)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

DMPK_MOUSE
θ value	7.1131e-05 (rank : 688)	NC score	0.811793 (rank : 496)
Query Neighborhood Hits	1407	Target Neighborhood Hits	908	Shared Neighborhood Hits	740
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

EPHA6_MOUSE
θ value	7.1131e-05 (rank : 689)	NC score	0.681191 (rank : 751)
Query Neighborhood Hits	1407	Target Neighborhood Hits	946	Shared Neighborhood Hits	748
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB6_HUMAN
θ value	7.1131e-05 (rank : 690)	NC score	0.608767 (rank : 804)
Query Neighborhood Hits	1407	Target Neighborhood Hits	912	Shared Neighborhood Hits	661
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ILK2_HUMAN
θ value	7.1131e-05 (rank : 691)	NC score	0.509525 (rank : 832)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	545
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

NCOA6_HUMAN
θ value	7.1131e-05 (rank : 692)	NC score	0.096971 (rank : 887)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1202	Shared Neighborhood Hits	352
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

STK16_MOUSE
θ value	7.1131e-05 (rank : 693)	NC score	0.861069 (rank : 258)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	737
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

VGFR1_MOUSE
θ value	7.1131e-05 (rank : 694)	NC score	0.638243 (rank : 780)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1118	Shared Neighborhood Hits	739
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

WEE1_HUMAN
θ value	7.1131e-05 (rank : 695)	NC score	0.823478 (rank : 459)
Query Neighborhood Hits	1407	Target Neighborhood Hits	777	Shared Neighborhood Hits	682
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

FGFR2_HUMAN
θ value	9.29e-05 (rank : 696)	NC score	0.721966 (rank : 679)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1062	Shared Neighborhood Hits	747
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	9.29e-05 (rank : 697)	NC score	0.723996 (rank : 677)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1062	Shared Neighborhood Hits	747
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

TNK1_MOUSE
θ value	9.29e-05 (rank : 698)	NC score	0.754872 (rank : 608)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	728
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

FGFR4_HUMAN
θ value	0.000121331 (rank : 699)	NC score	0.702188 (rank : 721)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	742
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

HIPK4_HUMAN
θ value	0.000121331 (rank : 700)	NC score	0.795497 (rank : 521)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

ILK_MOUSE
θ value	0.000121331 (rank : 701)	NC score	0.521548 (rank : 830)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	553
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

SPR1A_MOUSE
θ value	0.000121331 (rank : 702)	NC score	0.052911 (rank : 1099)
Query Neighborhood Hits	1407	Target Neighborhood Hits	343	Shared Neighborhood Hits	105
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

GUC2F_HUMAN
θ value	0.000158464 (rank : 703)	NC score	0.610338 (rank : 802)
Query Neighborhood Hits	1407	Target Neighborhood Hits	740	Shared Neighborhood Hits	636
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MYO15_MOUSE
θ value	0.000158464 (rank : 704)	NC score	0.033140 (rank : 1212)
Query Neighborhood Hits	1407	Target Neighborhood Hits	467	Shared Neighborhood Hits	144
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ACK1_HUMAN
θ value	0.00020696 (rank : 705)	NC score	0.748303 (rank : 626)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1140	Shared Neighborhood Hits	876
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ANPRA_HUMAN
θ value	0.00020696 (rank : 706)	NC score	0.535096 (rank : 820)
Query Neighborhood Hits	1407	Target Neighborhood Hits	612	Shared Neighborhood Hits	511
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

BMP2K_MOUSE
θ value	0.00020696 (rank : 707)	NC score	0.821759 (rank : 467)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	721
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

EPHA6_HUMAN
θ value	0.00020696 (rank : 708)	NC score	0.671074 (rank : 759)
Query Neighborhood Hits	1407	Target Neighborhood Hits	959	Shared Neighborhood Hits	749
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FGFR3_MOUSE
θ value	0.00020696 (rank : 709)	NC score	0.708410 (rank : 710)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1059	Shared Neighborhood Hits	750
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

RON_MOUSE
θ value	0.00020696 (rank : 710)	NC score	0.717740 (rank : 688)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	734
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

F5006_HUMAN
θ value	0.000270298 (rank : 711)	NC score	0.817623 (rank : 480)
Query Neighborhood Hits	1407	Target Neighborhood Hits	794	Shared Neighborhood Hits	714
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	0.000270298 (rank : 712)	NC score	0.825783 (rank : 456)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	716
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

FGFR1_HUMAN
θ value	0.000270298 (rank : 713)	NC score	0.716977 (rank : 693)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	751
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	0.000270298 (rank : 714)	NC score	0.717071 (rank : 690)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1068	Shared Neighborhood Hits	750
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

RET_MOUSE
θ value	0.000270298 (rank : 715)	NC score	0.735126 (rank : 652)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	741
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CD248_MOUSE
θ value	0.00035302 (rank : 716)	NC score	0.029417 (rank : 1246)
Query Neighborhood Hits	1407	Target Neighborhood Hits	578	Shared Neighborhood Hits	142
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

GSCR1_HUMAN
θ value	0.00035302 (rank : 717)	NC score	0.124649 (rank : 859)
Query Neighborhood Hits	1407	Target Neighborhood Hits	674	Shared Neighborhood Hits	311
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

LATS2_MOUSE
θ value	0.00035302 (rank : 718)	NC score	0.786721 (rank : 539)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	749
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

PRRT3_HUMAN
θ value	0.00035302 (rank : 719)	NC score	0.089056 (rank : 905)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	322
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

STK16_HUMAN
θ value	0.00035302 (rank : 720)	NC score	0.856888 (rank : 279)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	739
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

DDR2_MOUSE
θ value	0.000461057 (rank : 721)	NC score	0.711894 (rank : 704)
Query Neighborhood Hits	1407	Target Neighborhood Hits	813	Shared Neighborhood Hits	721
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

GNAS1_MOUSE
θ value	0.000461057 (rank : 722)	NC score	0.028247 (rank : 1257)
Query Neighborhood Hits	1407	Target Neighborhood Hits	651	Shared Neighborhood Hits	196
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

RET_HUMAN
θ value	0.000461057 (rank : 723)	NC score	0.735528 (rank : 651)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	744
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RON_HUMAN
θ value	0.000461057 (rank : 724)	NC score	0.727584 (rank : 669)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	740
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ANPRB_HUMAN
θ value	0.000602161 (rank : 725)	NC score	0.564712 (rank : 813)
Query Neighborhood Hits	1407	Target Neighborhood Hits	646	Shared Neighborhood Hits	546
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

DDR1_HUMAN
θ value	0.000602161 (rank : 726)	NC score	0.684662 (rank : 747)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	722
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

LATS1_HUMAN
θ value	0.00102713 (rank : 727)	NC score	0.795425 (rank : 522)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1057	Shared Neighborhood Hits	821
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

ROR1_HUMAN
θ value	0.00102713 (rank : 728)	NC score	0.707408 (rank : 711)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1018	Shared Neighborhood Hits	741
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR2_HUMAN
θ value	0.00102713 (rank : 729)	NC score	0.692834 (rank : 736)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1014	Shared Neighborhood Hits	739
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

DCC_MOUSE
θ value	0.00134147 (rank : 730)	NC score	0.062879 (rank : 1014)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	225
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

LATS1_MOUSE
θ value	0.00134147 (rank : 731)	NC score	0.793713 (rank : 527)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1027	Shared Neighborhood Hits	806
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

ROR1_MOUSE
θ value	0.00134147 (rank : 732)	NC score	0.709701 (rank : 709)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1025	Shared Neighborhood Hits	740
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

SAPS1_HUMAN
θ value	0.00134147 (rank : 733)	NC score	0.052399 (rank : 1103)
Query Neighborhood Hits	1407	Target Neighborhood Hits	704	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SON_MOUSE
θ value	0.00134147 (rank : 734)	NC score	0.089126 (rank : 904)
Query Neighborhood Hits	1407	Target Neighborhood Hits	957	Shared Neighborhood Hits	270
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SRPK1_HUMAN
θ value	0.00175202 (rank : 735)	NC score	0.533635 (rank : 823)
Query Neighborhood Hits	1407	Target Neighborhood Hits	706	Shared Neighborhood Hits	553
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	0.00175202 (rank : 736)	NC score	0.534547 (rank : 822)
Query Neighborhood Hits	1407	Target Neighborhood Hits	639	Shared Neighborhood Hits	528
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
θ value	0.00175202 (rank : 737)	NC score	0.529907 (rank : 825)
Query Neighborhood Hits	1407	Target Neighborhood Hits	664	Shared Neighborhood Hits	536
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	0.00175202 (rank : 738)	NC score	0.526937 (rank : 826)
Query Neighborhood Hits	1407	Target Neighborhood Hits	765	Shared Neighborhood Hits	552
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

TULP4_HUMAN
θ value	0.00175202 (rank : 739)	NC score	0.043992 (rank : 1147)
Query Neighborhood Hits	1407	Target Neighborhood Hits	426	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

BSN_MOUSE
θ value	0.00228821 (rank : 740)	NC score	0.101710 (rank : 878)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2057	Shared Neighborhood Hits	496
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

EPHAA_HUMAN
θ value	0.00228821 (rank : 741)	NC score	0.629787 (rank : 795)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	705
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MDC1_MOUSE
θ value	0.00228821 (rank : 742)	NC score	0.093854 (rank : 890)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	294
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MLL3_HUMAN
θ value	0.00228821 (rank : 743)	NC score	0.065614 (rank : 998)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1644	Shared Neighborhood Hits	368
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PI5PA_HUMAN
θ value	0.00228821 (rank : 744)	NC score	0.072829 (rank : 951)
Query Neighborhood Hits	1407	Target Neighborhood Hits	749	Shared Neighborhood Hits	278
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

TCGAP_HUMAN
θ value	0.00228821 (rank : 745)	NC score	0.032474 (rank : 1218)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	246
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANPRB_MOUSE
θ value	0.00298849 (rank : 746)	NC score	0.536598 (rank : 819)
Query Neighborhood Hits	1407	Target Neighborhood Hits	607	Shared Neighborhood Hits	525
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

CBP_MOUSE
θ value	0.00298849 (rank : 747)	NC score	0.076123 (rank : 937)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1051	Shared Neighborhood Hits	327
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PDLI7_HUMAN
θ value	0.00298849 (rank : 748)	NC score	0.023309 (rank : 1294)
Query Neighborhood Hits	1407	Target Neighborhood Hits	547	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PXK_MOUSE
θ value	0.00298849 (rank : 749)	NC score	0.222183 (rank : 848)
Query Neighborhood Hits	1407	Target Neighborhood Hits	320	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

STK23_HUMAN
θ value	0.00298849 (rank : 750)	NC score	0.525021 (rank : 828)
Query Neighborhood Hits	1407	Target Neighborhood Hits	556	Shared Neighborhood Hits	513
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	0.00298849 (rank : 751)	NC score	0.526377 (rank : 827)
Query Neighborhood Hits	1407	Target Neighborhood Hits	572	Shared Neighborhood Hits	517
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

BCL3_MOUSE
θ value	0.00390308 (rank : 752)	NC score	0.022742 (rank : 1297)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

BCL9_HUMAN
θ value	0.00390308 (rank : 753)	NC score	0.071772 (rank : 952)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1008	Shared Neighborhood Hits	302
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

DDR1_MOUSE
θ value	0.00390308 (rank : 754)	NC score	0.686464 (rank : 745)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

HCLS1_MOUSE
θ value	0.00390308 (rank : 755)	NC score	0.050956 (rank : 1115)
Query Neighborhood Hits	1407	Target Neighborhood Hits	329	Shared Neighborhood Hits	104
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HIPK1_HUMAN
θ value	0.00390308 (rank : 756)	NC score	0.753783 (rank : 609)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	722
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	0.00390308 (rank : 757)	NC score	0.753460 (rank : 611)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	720
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK2_HUMAN
θ value	0.00390308 (rank : 758)	NC score	0.749318 (rank : 623)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	721
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	0.00390308 (rank : 759)	NC score	0.749027 (rank : 624)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	725
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

MAGD1_HUMAN
θ value	0.00390308 (rank : 760)	NC score	0.016451 (rank : 1354)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

NRX2A_HUMAN
θ value	0.00390308 (rank : 761)	NC score	0.016372 (rank : 1356)
Query Neighborhood Hits	1407	Target Neighborhood Hits	614	Shared Neighborhood Hits	150
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.00390308 (rank : 762)	NC score	0.030057 (rank : 1240)
Query Neighborhood Hits	1407	Target Neighborhood Hits	481	Shared Neighborhood Hits	144
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PXK_HUMAN
θ value	0.00390308 (rank : 763)	NC score	0.175614 (rank : 850)
Query Neighborhood Hits	1407	Target Neighborhood Hits	216	Shared Neighborhood Hits	145
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

ANK2_HUMAN
θ value	0.00509761 (rank : 764)	NC score	0.052548 (rank : 1101)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1615	Shared Neighborhood Hits	320
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

FGFR4_MOUSE
θ value	0.00509761 (rank : 765)	NC score	0.679632 (rank : 753)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	734
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

NCOA6_MOUSE
θ value	0.00509761 (rank : 766)	NC score	0.100435 (rank : 879)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1076	Shared Neighborhood Hits	321
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

R3HD2_MOUSE
θ value	0.00509761 (rank : 767)	NC score	0.064193 (rank : 1004)
Query Neighborhood Hits	1407	Target Neighborhood Hits	397	Shared Neighborhood Hits	129
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

SEPT9_HUMAN
θ value	0.00509761 (rank : 768)	NC score	0.033479 (rank : 1210)
Query Neighborhood Hits	1407	Target Neighborhood Hits	706	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

STK40_HUMAN
θ value	0.00509761 (rank : 769)	NC score	0.783454 (rank : 542)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	0.00509761 (rank : 770)	NC score	0.782986 (rank : 543)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

AAK1_MOUSE
θ value	0.00665767 (rank : 771)	NC score	0.820752 (rank : 471)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1051	Shared Neighborhood Hits	826
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

DDEF1_MOUSE
θ value	0.00665767 (rank : 772)	NC score	0.026758 (rank : 1269)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ELF4_MOUSE
θ value	0.00665767 (rank : 773)	NC score	0.025230 (rank : 1281)
Query Neighborhood Hits	1407	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z2U4	Gene names	Elf4, Mef
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

GUC2G_MOUSE
θ value	0.00665767 (rank : 774)	NC score	0.546246 (rank : 816)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	548
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

SOX30_HUMAN
θ value	0.00665767 (rank : 775)	NC score	0.028159 (rank : 1258)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	104
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

STAT2_MOUSE
θ value	0.00665767 (rank : 776)	NC score	0.020784 (rank : 1314)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

UHMK1_HUMAN
θ value	0.00665767 (rank : 777)	NC score	0.763333 (rank : 596)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	690
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	0.00665767 (rank : 778)	NC score	0.762861 (rank : 600)
Query Neighborhood Hits	1407	Target Neighborhood Hits	809	Shared Neighborhood Hits	690
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

AAK1_HUMAN
θ value	0.00869519 (rank : 779)	NC score	0.820792 (rank : 470)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1077	Shared Neighborhood Hits	847
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

HIPK3_HUMAN
θ value	0.00869519 (rank : 780)	NC score	0.755054 (rank : 607)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	727
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	0.00869519 (rank : 781)	NC score	0.756854 (rank : 605)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	731
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

KIT_HUMAN
θ value	0.00869519 (rank : 782)	NC score	0.647927 (rank : 770)
Query Neighborhood Hits	1407	Target Neighborhood Hits	953	Shared Neighborhood Hits	733
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

SC24C_HUMAN
θ value	0.00869519 (rank : 783)	NC score	0.058768 (rank : 1042)
Query Neighborhood Hits	1407	Target Neighborhood Hits	662	Shared Neighborhood Hits	223
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TRIB2_HUMAN
θ value	0.00869519 (rank : 784)	NC score	0.739686 (rank : 646)
Query Neighborhood Hits	1407	Target Neighborhood Hits	657	Shared Neighborhood Hits	608
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	0.00869519 (rank : 785)	NC score	0.739288 (rank : 647)
Query Neighborhood Hits	1407	Target Neighborhood Hits	653	Shared Neighborhood Hits	604
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

ZIM10_HUMAN
θ value	0.00869519 (rank : 786)	NC score	0.032331 (rank : 1219)
Query Neighborhood Hits	1407	Target Neighborhood Hits	577	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

BAZ2A_HUMAN
θ value	0.0113563 (rank : 787)	NC score	0.039816 (rank : 1170)
Query Neighborhood Hits	1407	Target Neighborhood Hits	780	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

PRP4B_HUMAN
θ value	0.0113563 (rank : 788)	NC score	0.749371 (rank : 622)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1030	Shared Neighborhood Hits	726
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	0.0113563 (rank : 789)	NC score	0.747394 (rank : 632)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1040	Shared Neighborhood Hits	723
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

ROR2_MOUSE
θ value	0.0113563 (rank : 790)	NC score	0.669341 (rank : 760)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1000	Shared Neighborhood Hits	719
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

CASL_HUMAN
θ value	0.0148317 (rank : 791)	NC score	0.030888 (rank : 1234)
Query Neighborhood Hits	1407	Target Neighborhood Hits	259	Shared Neighborhood Hits	63
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CO002_HUMAN
θ value	0.0148317 (rank : 792)	NC score	0.056176 (rank : 1064)
Query Neighborhood Hits	1407	Target Neighborhood Hits	387	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

KIT_MOUSE
θ value	0.0148317 (rank : 793)	NC score	0.639069 (rank : 779)
Query Neighborhood Hits	1407	Target Neighborhood Hits	949	Shared Neighborhood Hits	732
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MEGF9_HUMAN
θ value	0.0148317 (rank : 794)	NC score	0.025191 (rank : 1282)
Query Neighborhood Hits	1407	Target Neighborhood Hits	557	Shared Neighborhood Hits	149
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

OGFR_HUMAN
θ value	0.0148317 (rank : 795)	NC score	0.086123 (rank : 916)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1582	Shared Neighborhood Hits	396
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHC2_HUMAN
θ value	0.0148317 (rank : 796)	NC score	0.041429 (rank : 1162)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	147
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

ZEP1_HUMAN
θ value	0.0148317 (rank : 797)	NC score	-0.001105 (rank : 1575)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1036	Shared Neighborhood Hits	143
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ADA12_MOUSE
θ value	0.0193708 (rank : 798)	NC score	0.003619 (rank : 1509)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	119
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ATX2L_HUMAN
θ value	0.0193708 (rank : 799)	NC score	0.068392 (rank : 974)
Query Neighborhood Hits	1407	Target Neighborhood Hits	443	Shared Neighborhood Hits	179
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

GGA2_HUMAN
θ value	0.0193708 (rank : 800)	NC score	0.011643 (rank : 1407)
Query Neighborhood Hits	1407	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

IQEC3_MOUSE
θ value	0.0193708 (rank : 801)	NC score	0.027652 (rank : 1262)
Query Neighborhood Hits	1407	Target Neighborhood Hits	274	Shared Neighborhood Hits	116
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NTKL_MOUSE
θ value	0.0193708 (rank : 802)	NC score	0.398101 (rank : 837)
Query Neighborhood Hits	1407	Target Neighborhood Hits	326	Shared Neighborhood Hits	289
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PO6F1_MOUSE
θ value	0.0193708 (rank : 803)	NC score	0.013660 (rank : 1385)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	127
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

ATX2L_MOUSE
θ value	0.0252991 (rank : 804)	NC score	0.060892 (rank : 1029)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	154
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

CGRE1_HUMAN
θ value	0.0252991 (rank : 805)	NC score	0.025899 (rank : 1272)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	77
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

DOK2_MOUSE
θ value	0.0252991 (rank : 806)	NC score	0.028851 (rank : 1254)
Query Neighborhood Hits	1407	Target Neighborhood Hits	244	Shared Neighborhood Hits	83
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

NU214_HUMAN
θ value	0.0252991 (rank : 807)	NC score	0.075413 (rank : 942)
Query Neighborhood Hits	1407	Target Neighborhood Hits	657	Shared Neighborhood Hits	168
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

SOX13_HUMAN
θ value	0.0252991 (rank : 808)	NC score	0.027242 (rank : 1268)
Query Neighborhood Hits	1407	Target Neighborhood Hits	464	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SOX13_MOUSE
θ value	0.0252991 (rank : 809)	NC score	0.030345 (rank : 1237)
Query Neighborhood Hits	1407	Target Neighborhood Hits	495	Shared Neighborhood Hits	143
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SSBP4_HUMAN
θ value	0.0252991 (rank : 810)	NC score	0.037154 (rank : 1183)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

TRI66_MOUSE
θ value	0.0252991 (rank : 811)	NC score	0.030596 (rank : 1236)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	139
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

YLPM1_MOUSE
θ value	0.0252991 (rank : 812)	NC score	0.093720 (rank : 891)
Query Neighborhood Hits	1407	Target Neighborhood Hits	505	Shared Neighborhood Hits	222
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZEP1_MOUSE
θ value	0.0252991 (rank : 813)	NC score	-0.001822 (rank : 1582)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1063	Shared Neighborhood Hits	154
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

CI096_HUMAN
θ value	0.0330416 (rank : 814)	NC score	0.840186 (rank : 378)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	723
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

FMN1B_MOUSE
θ value	0.0330416 (rank : 815)	NC score	0.052992 (rank : 1097)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	173
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

IRAK3_MOUSE
θ value	0.0330416 (rank : 816)	NC score	0.700724 (rank : 725)
Query Neighborhood Hits	1407	Target Neighborhood Hits	628	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KLF17_HUMAN
θ value	0.0330416 (rank : 817)	NC score	-0.012103 (rank : 1623)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	128
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

NUMBL_HUMAN
θ value	0.0330416 (rank : 818)	NC score	0.031419 (rank : 1231)
Query Neighborhood Hits	1407	Target Neighborhood Hits	394	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

PSL1_HUMAN
θ value	0.0330416 (rank : 819)	NC score	0.042862 (rank : 1150)
Query Neighborhood Hits	1407	Target Neighborhood Hits	650	Shared Neighborhood Hits	195
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RYK_MOUSE
θ value	0.0330416 (rank : 820)	NC score	0.620924 (rank : 800)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	654
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

TARSH_HUMAN
θ value	0.0330416 (rank : 821)	NC score	0.099548 (rank : 880)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	270
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

DIDO1_HUMAN
θ value	0.0431538 (rank : 822)	NC score	0.045482 (rank : 1142)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	253
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GON4L_MOUSE
θ value	0.0431538 (rank : 823)	NC score	0.030237 (rank : 1238)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	112
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

SYNJ1_MOUSE
θ value	0.0431538 (rank : 824)	NC score	0.070963 (rank : 958)
Query Neighborhood Hits	1407	Target Neighborhood Hits	516	Shared Neighborhood Hits	250
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TPO_MOUSE
θ value	0.0431538 (rank : 825)	NC score	0.029950 (rank : 1242)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

DCP1A_HUMAN
θ value	0.0563607 (rank : 826)	NC score	0.051717 (rank : 1109)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

HXD3_HUMAN
θ value	0.0563607 (rank : 827)	NC score	-0.005919 (rank : 1602)
Query Neighborhood Hits	1407	Target Neighborhood Hits	433	Shared Neighborhood Hits	60
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

IWS1_MOUSE
θ value	0.0563607 (rank : 828)	NC score	0.035922 (rank : 1190)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1258	Shared Neighborhood Hits	216
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NSD1_MOUSE
θ value	0.0563607 (rank : 829)	NC score	0.029363 (rank : 1247)
Query Neighborhood Hits	1407	Target Neighborhood Hits	472	Shared Neighborhood Hits	109
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PCLO_HUMAN
θ value	0.0563607 (rank : 830)	NC score	0.090798 (rank : 895)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2046	Shared Neighborhood Hits	459
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PTPRN_MOUSE
θ value	0.0563607 (rank : 831)	NC score	0.002276 (rank : 1528)
Query Neighborhood Hits	1407	Target Neighborhood Hits	240	Shared Neighborhood Hits	68
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

CCNK_MOUSE
θ value	0.0736092 (rank : 832)	NC score	0.066939 (rank : 989)
Query Neighborhood Hits	1407	Target Neighborhood Hits	350	Shared Neighborhood Hits	189
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

KCNK4_MOUSE
θ value	0.0736092 (rank : 833)	NC score	0.008440 (rank : 1443)
Query Neighborhood Hits	1407	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

MINT_MOUSE
θ value	0.0736092 (rank : 834)	NC score	0.063749 (rank : 1010)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1514	Shared Neighborhood Hits	346
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PCLO_MOUSE
θ value	0.0736092 (rank : 835)	NC score	0.088946 (rank : 906)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2275	Shared Neighborhood Hits	512
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TBX21_MOUSE
θ value	0.0736092 (rank : 836)	NC score	0.006227 (rank : 1478)
Query Neighborhood Hits	1407	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

UBP42_HUMAN
θ value	0.0736092 (rank : 837)	NC score	0.014769 (rank : 1369)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

CBP_HUMAN
θ value	0.0961366 (rank : 838)	NC score	0.074595 (rank : 946)
Query Neighborhood Hits	1407	Target Neighborhood Hits	941	Shared Neighborhood Hits	307
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CECR2_HUMAN
θ value	0.0961366 (rank : 839)	NC score	0.031977 (rank : 1222)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	153
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CIC_HUMAN
θ value	0.0961366 (rank : 840)	NC score	0.070219 (rank : 962)
Query Neighborhood Hits	1407	Target Neighborhood Hits	992	Shared Neighborhood Hits	337
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO5A2_HUMAN
θ value	0.0961366 (rank : 841)	NC score	0.020303 (rank : 1319)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	178
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

EPN3_MOUSE
θ value	0.0961366 (rank : 842)	NC score	0.031812 (rank : 1224)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	120
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

MYO15_HUMAN
θ value	0.0961366 (rank : 843)	NC score	0.034150 (rank : 1204)
Query Neighborhood Hits	1407	Target Neighborhood Hits	671	Shared Neighborhood Hits	213
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PACE1_MOUSE
θ value	0.0961366 (rank : 844)	NC score	0.098909 (rank : 883)
Query Neighborhood Hits	1407	Target Neighborhood Hits	92	Shared Neighborhood Hits	62
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

REL_MOUSE
θ value	0.0961366 (rank : 845)	NC score	0.007836 (rank : 1457)
Query Neighborhood Hits	1407	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

SRRM2_MOUSE
θ value	0.0961366 (rank : 846)	NC score	0.104330 (rank : 874)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1470	Shared Neighborhood Hits	356
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ZN645_HUMAN
θ value	0.0961366 (rank : 847)	NC score	0.037721 (rank : 1180)
Query Neighborhood Hits	1407	Target Neighborhood Hits	265	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

DAB2_HUMAN
θ value	0.125558 (rank : 848)	NC score	0.024848 (rank : 1284)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	70
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

ENAH_HUMAN
θ value	0.125558 (rank : 849)	NC score	0.064113 (rank : 1005)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	202
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

NMDE4_HUMAN
θ value	0.125558 (rank : 850)	NC score	0.005557 (rank : 1486)
Query Neighborhood Hits	1407	Target Neighborhood Hits	133	Shared Neighborhood Hits	45
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

SIX5_MOUSE
θ value	0.125558 (rank : 851)	NC score	0.016693 (rank : 1353)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	75
SwissProt Accessions	P70178	Gene names	Six5, Dmahp
Domain Architecture
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein homolog).

AFF4_MOUSE
θ value	0.163984 (rank : 852)	NC score	0.027659 (rank : 1261)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	110
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ATX7_HUMAN
θ value	0.163984 (rank : 853)	NC score	0.031607 (rank : 1225)
Query Neighborhood Hits	1407	Target Neighborhood Hits	351	Shared Neighborhood Hits	104
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CG1_HUMAN
θ value	0.163984 (rank : 854)	NC score	0.048714 (rank : 1133)
Query Neighborhood Hits	1407	Target Neighborhood Hits	222	Shared Neighborhood Hits	99
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CSKI1_MOUSE
θ value	0.163984 (rank : 855)	NC score	0.075402 (rank : 943)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1031	Shared Neighborhood Hits	325
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ISY1_HUMAN
θ value	0.163984 (rank : 856)	NC score	0.014401 (rank : 1376)
Query Neighborhood Hits	1407	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

LIMD1_MOUSE
θ value	0.163984 (rank : 857)	NC score	0.023604 (rank : 1291)
Query Neighborhood Hits	1407	Target Neighborhood Hits	291	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

SP5_MOUSE
θ value	0.163984 (rank : 858)	NC score	-0.015959 (rank : 1633)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

UBQL3_HUMAN
θ value	0.163984 (rank : 859)	NC score	0.013070 (rank : 1389)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

X3CL1_HUMAN
θ value	0.163984 (rank : 860)	NC score	0.020144 (rank : 1321)
Query Neighborhood Hits	1407	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

ZN687_HUMAN
θ value	0.163984 (rank : 861)	NC score	-0.003048 (rank : 1590)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1244	Shared Neighborhood Hits	224
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

AATK_HUMAN
θ value	0.21417 (rank : 862)	NC score	0.716936 (rank : 694)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1243	Shared Neighborhood Hits	858
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

BSN_HUMAN
θ value	0.21417 (rank : 863)	NC score	0.097515 (rank : 886)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1537	Shared Neighborhood Hits	409
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CIC_MOUSE
θ value	0.21417 (rank : 864)	NC score	0.061649 (rank : 1020)
Query Neighborhood Hits	1407	Target Neighborhood Hits	742	Shared Neighborhood Hits	277
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

GAK10_HUMAN
θ value	0.21417 (rank : 865)	NC score	0.017575 (rank : 1347)
Query Neighborhood Hits	1407	Target Neighborhood Hits	289	Shared Neighborhood Hits	92
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

JPH2_HUMAN
θ value	0.21417 (rank : 866)	NC score	0.034775 (rank : 1199)
Query Neighborhood Hits	1407	Target Neighborhood Hits	639	Shared Neighborhood Hits	202
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K1802_HUMAN
θ value	0.21417 (rank : 867)	NC score	0.053442 (rank : 1094)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1378	Shared Neighborhood Hits	321
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MADCA_MOUSE
θ value	0.21417 (rank : 868)	NC score	0.013841 (rank : 1383)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

MAP1A_HUMAN
θ value	0.21417 (rank : 869)	NC score	0.050772 (rank : 1119)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1626	Shared Neighborhood Hits	300
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MLL2_HUMAN
θ value	0.21417 (rank : 870)	NC score	0.083365 (rank : 922)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1788	Shared Neighborhood Hits	437
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NTKL_HUMAN
θ value	0.21417 (rank : 871)	NC score	0.312500 (rank : 843)
Query Neighborhood Hits	1407	Target Neighborhood Hits	266	Shared Neighborhood Hits	224
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

OSBP2_MOUSE
θ value	0.21417 (rank : 872)	NC score	0.005801 (rank : 1483)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RC3H1_HUMAN
θ value	0.21417 (rank : 873)	NC score	0.012012 (rank : 1404)
Query Neighborhood Hits	1407	Target Neighborhood Hits	433	Shared Neighborhood Hits	87
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RYK_HUMAN
θ value	0.21417 (rank : 874)	NC score	0.605924 (rank : 807)
Query Neighborhood Hits	1407	Target Neighborhood Hits	701	Shared Neighborhood Hits	643
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

SP5_HUMAN
θ value	0.21417 (rank : 875)	NC score	-0.016287 (rank : 1635)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	91
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

ZAR1_HUMAN
θ value	0.21417 (rank : 876)	NC score	0.033932 (rank : 1206)
Query Neighborhood Hits	1407	Target Neighborhood Hits	163	Shared Neighborhood Hits	51
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ARMX2_MOUSE
θ value	0.279714 (rank : 877)	NC score	0.029555 (rank : 1245)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	129
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

CABIN_HUMAN
θ value	0.279714 (rank : 878)	NC score	0.051195 (rank : 1113)
Query Neighborhood Hits	1407	Target Neighborhood Hits	490	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CEL_HUMAN
θ value	0.279714 (rank : 879)	NC score	0.035449 (rank : 1195)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	265
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CN032_MOUSE
θ value	0.279714 (rank : 880)	NC score	0.088306 (rank : 908)
Query Neighborhood Hits	1407	Target Neighborhood Hits	233	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

CO039_HUMAN
θ value	0.279714 (rank : 881)	NC score	0.053618 (rank : 1092)
Query Neighborhood Hits	1407	Target Neighborhood Hits	264	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CO039_MOUSE
θ value	0.279714 (rank : 882)	NC score	0.059128 (rank : 1036)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	190
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CP045_MOUSE
θ value	0.279714 (rank : 883)	NC score	0.015285 (rank : 1364)
Query Neighborhood Hits	1407	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R1Y2, Q3UVX0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf45 homolog.

CSPG5_HUMAN
θ value	0.279714 (rank : 884)	NC score	0.027494 (rank : 1266)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	76
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

GA2L2_MOUSE
θ value	0.279714 (rank : 885)	NC score	0.034264 (rank : 1202)
Query Neighborhood Hits	1407	Target Neighborhood Hits	395	Shared Neighborhood Hits	133
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

HCN2_HUMAN
θ value	0.279714 (rank : 886)	NC score	0.027601 (rank : 1263)
Query Neighborhood Hits	1407	Target Neighborhood Hits	369	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HXD3_MOUSE
θ value	0.279714 (rank : 887)	NC score	-0.006553 (rank : 1605)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	60
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

K1849_MOUSE
θ value	0.279714 (rank : 888)	NC score	0.007087 (rank : 1471)
Query Neighborhood Hits	1407	Target Neighborhood Hits	335	Shared Neighborhood Hits	66
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KCNQ1_MOUSE
θ value	0.279714 (rank : 889)	NC score	0.001457 (rank : 1541)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

MAP4_HUMAN
θ value	0.279714 (rank : 890)	NC score	0.056971 (rank : 1057)
Query Neighborhood Hits	1407	Target Neighborhood Hits	428	Shared Neighborhood Hits	143
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MEF2B_HUMAN
θ value	0.279714 (rank : 891)	NC score	0.022522 (rank : 1300)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	71
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

NFRKB_MOUSE
θ value	0.279714 (rank : 892)	NC score	0.056717 (rank : 1059)
Query Neighborhood Hits	1407	Target Neighborhood Hits	393	Shared Neighborhood Hits	150
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

NOTC2_HUMAN
θ value	0.279714 (rank : 893)	NC score	0.004622 (rank : 1497)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1113	Shared Neighborhood Hits	162
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PI51C_MOUSE
θ value	0.279714 (rank : 894)	NC score	0.006388 (rank : 1477)
Query Neighborhood Hits	1407	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

PTN22_MOUSE
θ value	0.279714 (rank : 895)	NC score	0.001571 (rank : 1536)
Query Neighborhood Hits	1407	Target Neighborhood Hits	179	Shared Neighborhood Hits	43
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_MOUSE
θ value	0.279714 (rank : 896)	NC score	0.036811 (rank : 1186)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	265
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

APXL_HUMAN
θ value	0.365318 (rank : 897)	NC score	0.035518 (rank : 1194)
Query Neighborhood Hits	1407	Target Neighborhood Hits	553	Shared Neighborhood Hits	134
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

BAG3_MOUSE
θ value	0.365318 (rank : 898)	NC score	0.044968 (rank : 1144)
Query Neighborhood Hits	1407	Target Neighborhood Hits	513	Shared Neighborhood Hits	181
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BAI2_MOUSE
θ value	0.365318 (rank : 899)	NC score	-0.004863 (rank : 1600)
Query Neighborhood Hits	1407	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BRD8_MOUSE
θ value	0.365318 (rank : 900)	NC score	0.035359 (rank : 1196)
Query Neighborhood Hits	1407	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

CHD5_HUMAN
θ value	0.365318 (rank : 901)	NC score	0.001795 (rank : 1532)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CIKS_HUMAN
θ value	0.365318 (rank : 902)	NC score	0.023791 (rank : 1288)
Query Neighborhood Hits	1407	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

DAB1_HUMAN
θ value	0.365318 (rank : 903)	NC score	0.025564 (rank : 1279)
Query Neighborhood Hits	1407	Target Neighborhood Hits	219	Shared Neighborhood Hits	81
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

EFS_MOUSE
θ value	0.365318 (rank : 904)	NC score	0.052968 (rank : 1098)
Query Neighborhood Hits	1407	Target Neighborhood Hits	389	Shared Neighborhood Hits	133
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EHMT2_MOUSE
θ value	0.365318 (rank : 905)	NC score	0.025751 (rank : 1277)
Query Neighborhood Hits	1407	Target Neighborhood Hits	750	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GAK11_HUMAN
θ value	0.365318 (rank : 906)	NC score	0.019875 (rank : 1326)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	133
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
θ value	0.365318 (rank : 907)	NC score	0.019338 (rank : 1329)
Query Neighborhood Hits	1407	Target Neighborhood Hits	406	Shared Neighborhood Hits	132
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	0.365318 (rank : 908)	NC score	0.019457 (rank : 1328)
Query Neighborhood Hits	1407	Target Neighborhood Hits	415	Shared Neighborhood Hits	135
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	0.365318 (rank : 909)	NC score	0.020356 (rank : 1318)
Query Neighborhood Hits	1407	Target Neighborhood Hits	429	Shared Neighborhood Hits	135
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IER5_MOUSE
θ value	0.365318 (rank : 910)	NC score	0.031422 (rank : 1230)
Query Neighborhood Hits	1407	Target Neighborhood Hits	110	Shared Neighborhood Hits	47
SwissProt Accessions	O89113, Q8CGI0	Gene names	Ier5
Domain Architecture	No domain graphic available
Description	Immediate early response gene 5 protein.

KLF16_MOUSE
θ value	0.365318 (rank : 911)	NC score	-0.018710 (rank : 1645)
Query Neighborhood Hits	1407	Target Neighborhood Hits	719	Shared Neighborhood Hits	52
SwissProt Accessions	P58334, Q3U3Y4, Q8C8S2	Gene names	Klf16, Bteb4, Drrf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Dopamine receptor-regulating factor).

NCOA1_MOUSE
θ value	0.365318 (rank : 912)	NC score	0.008330 (rank : 1445)
Query Neighborhood Hits	1407	Target Neighborhood Hits	196	Shared Neighborhood Hits	48
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

PHLPP_HUMAN
θ value	0.365318 (rank : 913)	NC score	0.014761 (rank : 1371)
Query Neighborhood Hits	1407	Target Neighborhood Hits	604	Shared Neighborhood Hits	137
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

SL9A5_HUMAN
θ value	0.365318 (rank : 914)	NC score	0.004755 (rank : 1496)
Query Neighborhood Hits	1407	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

SPR1A_HUMAN
θ value	0.365318 (rank : 915)	NC score	0.034208 (rank : 1203)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

SYNJ1_HUMAN
θ value	0.365318 (rank : 916)	NC score	0.059884 (rank : 1032)
Query Neighborhood Hits	1407	Target Neighborhood Hits	498	Shared Neighborhood Hits	229
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCOF_HUMAN
θ value	0.365318 (rank : 917)	NC score	0.054267 (rank : 1085)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	154
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

ZIM10_MOUSE
θ value	0.365318 (rank : 918)	NC score	0.025514 (rank : 1280)
Query Neighborhood Hits	1407	Target Neighborhood Hits	430	Shared Neighborhood Hits	136
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

3BP1_HUMAN
θ value	0.47712 (rank : 919)	NC score	0.037814 (rank : 1179)
Query Neighborhood Hits	1407	Target Neighborhood Hits	376	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AIM1_HUMAN
θ value	0.47712 (rank : 920)	NC score	0.023641 (rank : 1290)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

AKAP8_HUMAN
θ value	0.47712 (rank : 921)	NC score	0.007279 (rank : 1468)
Query Neighborhood Hits	1407	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

BHLH2_HUMAN
θ value	0.47712 (rank : 922)	NC score	0.005389 (rank : 1490)
Query Neighborhood Hits	1407	Target Neighborhood Hits	80	Shared Neighborhood Hits	11
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

CSKI1_HUMAN
θ value	0.47712 (rank : 923)	NC score	0.076557 (rank : 936)
Query Neighborhood Hits	1407	Target Neighborhood Hits	997	Shared Neighborhood Hits	309
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DMP1_HUMAN
θ value	0.47712 (rank : 924)	NC score	0.019179 (rank : 1331)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	65
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

ELF1_MOUSE
θ value	0.47712 (rank : 925)	NC score	0.010548 (rank : 1415)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

FA47B_HUMAN
θ value	0.47712 (rank : 926)	NC score	0.048180 (rank : 1135)
Query Neighborhood Hits	1407	Target Neighborhood Hits	431	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GLI3_HUMAN
θ value	0.47712 (rank : 927)	NC score	-0.015817 (rank : 1632)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	102
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

MINT_HUMAN
θ value	0.47712 (rank : 928)	NC score	0.053338 (rank : 1095)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1291	Shared Neighborhood Hits	278
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NUP53_MOUSE
θ value	0.47712 (rank : 929)	NC score	0.021950 (rank : 1306)
Query Neighborhood Hits	1407	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

SCAP_HUMAN
θ value	0.47712 (rank : 930)	NC score	-0.000799 (rank : 1573)
Query Neighborhood Hits	1407	Target Neighborhood Hits	368	Shared Neighborhood Hits	52
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

SNPC4_MOUSE
θ value	0.47712 (rank : 931)	NC score	0.025096 (rank : 1283)
Query Neighborhood Hits	1407	Target Neighborhood Hits	237	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

SYNJ2_MOUSE
θ value	0.47712 (rank : 932)	NC score	0.019991 (rank : 1323)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SYNPO_MOUSE
θ value	0.47712 (rank : 933)	NC score	0.032768 (rank : 1214)
Query Neighborhood Hits	1407	Target Neighborhood Hits	242	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TENS4_MOUSE
θ value	0.47712 (rank : 934)	NC score	0.048871 (rank : 1132)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	0.47712 (rank : 935)	NC score	0.510268 (rank : 831)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	588
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TNR3_HUMAN
θ value	0.47712 (rank : 936)	NC score	0.003436 (rank : 1510)
Query Neighborhood Hits	1407	Target Neighborhood Hits	145	Shared Neighborhood Hits	24
SwissProt Accessions	P36941	Gene names	LTBR, TNFCR, TNFRSF3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor C receptor).

UBP6_HUMAN
θ value	0.47712 (rank : 937)	NC score	0.000407 (rank : 1558)
Query Neighborhood Hits	1407	Target Neighborhood Hits	188	Shared Neighborhood Hits	35
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

ZN385_HUMAN
θ value	0.47712 (rank : 938)	NC score	0.032709 (rank : 1216)
Query Neighborhood Hits	1407	Target Neighborhood Hits	614	Shared Neighborhood Hits	168
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZN687_MOUSE
θ value	0.47712 (rank : 939)	NC score	-0.007914 (rank : 1611)
Query Neighborhood Hits	1407	Target Neighborhood Hits	913	Shared Neighborhood Hits	131
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

BAZ2A_MOUSE
θ value	0.62314 (rank : 940)	NC score	0.044011 (rank : 1146)
Query Neighborhood Hits	1407	Target Neighborhood Hits	744	Shared Neighborhood Hits	205
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CS021_HUMAN
θ value	0.62314 (rank : 941)	NC score	0.016136 (rank : 1358)
Query Neighborhood Hits	1407	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

EP300_HUMAN
θ value	0.62314 (rank : 942)	NC score	0.075562 (rank : 940)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	292
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FBLN2_MOUSE
θ value	0.62314 (rank : 943)	NC score	-0.001267 (rank : 1577)
Query Neighborhood Hits	1407	Target Neighborhood Hits	505	Shared Neighborhood Hits	76
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

GAK6_HUMAN
θ value	0.62314 (rank : 944)	NC score	0.019889 (rank : 1325)
Query Neighborhood Hits	1407	Target Neighborhood Hits	392	Shared Neighborhood Hits	132
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IC1_MOUSE
θ value	0.62314 (rank : 945)	NC score	-0.002068 (rank : 1585)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	36
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

IP3KA_HUMAN
θ value	0.62314 (rank : 946)	NC score	0.007802 (rank : 1459)
Query Neighborhood Hits	1407	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

LPP_HUMAN
θ value	0.62314 (rank : 947)	NC score	0.046298 (rank : 1139)
Query Neighborhood Hits	1407	Target Neighborhood Hits	775	Shared Neighborhood Hits	226
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MLL3_MOUSE
θ value	0.62314 (rank : 948)	NC score	0.055222 (rank : 1072)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1399	Shared Neighborhood Hits	323
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PF21A_HUMAN
θ value	0.62314 (rank : 949)	NC score	0.016088 (rank : 1359)
Query Neighborhood Hits	1407	Target Neighborhood Hits	303	Shared Neighborhood Hits	57
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

SH22A_MOUSE
θ value	0.62314 (rank : 950)	NC score	0.042524 (rank : 1155)
Query Neighborhood Hits	1407	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

TULP4_MOUSE
θ value	0.62314 (rank : 951)	NC score	0.027550 (rank : 1265)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TXLNA_HUMAN
θ value	0.62314 (rank : 952)	NC score	0.029170 (rank : 1250)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	126
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

YAP1_HUMAN
θ value	0.62314 (rank : 953)	NC score	0.017989 (rank : 1340)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZC3H6_HUMAN
θ value	0.62314 (rank : 954)	NC score	0.020395 (rank : 1317)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ZN710_HUMAN
θ value	0.62314 (rank : 955)	NC score	-0.020502 (rank : 1652)
Query Neighborhood Hits	1407	Target Neighborhood Hits	796	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N1W2, Q6ZMK9, Q8NDU0	Gene names	ZNF710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.

ANKS1_MOUSE
θ value	0.813845 (rank : 956)	NC score	0.039944 (rank : 1169)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	85
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

BNC2_HUMAN
θ value	0.813845 (rank : 957)	NC score	0.007512 (rank : 1464)
Query Neighborhood Hits	1407	Target Neighborhood Hits	439	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZN30, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0	Gene names	BNC2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

BNC2_MOUSE
θ value	0.813845 (rank : 958)	NC score	0.007349 (rank : 1467)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMQ3, Q6T3A4	Gene names	Bnc2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

CI079_HUMAN
θ value	0.813845 (rank : 959)	NC score	0.040223 (rank : 1165)
Query Neighborhood Hits	1407	Target Neighborhood Hits	288	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CSPG5_MOUSE
θ value	0.813845 (rank : 960)	NC score	0.025652 (rank : 1278)
Query Neighborhood Hits	1407	Target Neighborhood Hits	211	Shared Neighborhood Hits	68
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

EP400_MOUSE
θ value	0.813845 (rank : 961)	NC score	0.039378 (rank : 1173)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	219
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

FMN1A_MOUSE
θ value	0.813845 (rank : 962)	NC score	0.051683 (rank : 1110)
Query Neighborhood Hits	1407	Target Neighborhood Hits	423	Shared Neighborhood Hits	179
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FOG1_MOUSE
θ value	0.813845 (rank : 963)	NC score	0.001644 (rank : 1533)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1237	Shared Neighborhood Hits	246
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GP152_HUMAN
θ value	0.813845 (rank : 964)	NC score	0.009510 (rank : 1429)
Query Neighborhood Hits	1407	Target Neighborhood Hits	636	Shared Neighborhood Hits	129
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

ITSN1_HUMAN
θ value	0.813845 (rank : 965)	NC score	0.058362 (rank : 1044)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1757	Shared Neighborhood Hits	244
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

KC1AL_HUMAN
θ value	0.813845 (rank : 966)	NC score	0.640572 (rank : 778)
Query Neighborhood Hits	1407	Target Neighborhood Hits	734	Shared Neighborhood Hits	674
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

MUC13_MOUSE
θ value	0.813845 (rank : 967)	NC score	0.056782 (rank : 1058)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	118
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

MUC7_HUMAN
θ value	0.813845 (rank : 968)	NC score	0.107251 (rank : 867)
Query Neighborhood Hits	1407	Target Neighborhood Hits	538	Shared Neighborhood Hits	238
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PCQAP_HUMAN
θ value	0.813845 (rank : 969)	NC score	0.090039 (rank : 897)
Query Neighborhood Hits	1407	Target Neighborhood Hits	549	Shared Neighborhood Hits	188
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PI51C_HUMAN
θ value	0.813845 (rank : 970)	NC score	0.008871 (rank : 1435)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	30
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

RECQ5_HUMAN
θ value	0.813845 (rank : 971)	NC score	0.007830 (rank : 1458)
Query Neighborhood Hits	1407	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SFR16_MOUSE
θ value	0.813845 (rank : 972)	NC score	0.028296 (rank : 1255)
Query Neighborhood Hits	1407	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

SYT8_HUMAN
θ value	0.813845 (rank : 973)	NC score	0.012528 (rank : 1394)
Query Neighborhood Hits	1407	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

ZDH14_HUMAN
θ value	0.813845 (rank : 974)	NC score	0.000588 (rank : 1553)
Query Neighborhood Hits	1407	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZN3, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q9H7F1	Gene names	ZDHHC14
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP).

ZN217_HUMAN
θ value	0.813845 (rank : 975)	NC score	-0.016436 (rank : 1636)
Query Neighborhood Hits	1407	Target Neighborhood Hits	905	Shared Neighborhood Hits	112
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

4ET_HUMAN
θ value	1.06291 (rank : 976)	NC score	0.010714 (rank : 1412)
Query Neighborhood Hits	1407	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

AKA10_MOUSE
θ value	1.06291 (rank : 977)	NC score	0.012133 (rank : 1401)
Query Neighborhood Hits	1407	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6	Gene names	Akap10
Domain Architecture	No domain graphic available
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

C1QR1_HUMAN
θ value	1.06291 (rank : 978)	NC score	-0.000522 (rank : 1566)
Query Neighborhood Hits	1407	Target Neighborhood Hits	493	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

CCD45_MOUSE
θ value	1.06291 (rank : 979)	NC score	0.039531 (rank : 1172)
Query Neighborhood Hits	1407	Target Neighborhood Hits	663	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CP045_HUMAN
θ value	1.06291 (rank : 980)	NC score	0.015171 (rank : 1365)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q96MC5, O00223, O75769, Q8IZ36, Q96H25	Gene names	C16orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf45.

EGR1_MOUSE
θ value	1.06291 (rank : 981)	NC score	-0.017663 (rank : 1639)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	85
SwissProt Accessions	P08046, Q61777	Gene names	Egr1, Egr-1, Krox-24
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A).

FGD3_HUMAN
θ value	1.06291 (rank : 982)	NC score	0.004770 (rank : 1495)
Query Neighborhood Hits	1407	Target Neighborhood Hits	249	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FOXN4_HUMAN
θ value	1.06291 (rank : 983)	NC score	-0.001948 (rank : 1584)
Query Neighborhood Hits	1407	Target Neighborhood Hits	248	Shared Neighborhood Hits	56
SwissProt Accessions	Q96NZ1, Q6ZMR4, Q96NZ0	Gene names	FOXN4
Domain Architecture	No domain graphic available
Description	Forkhead box protein N4.

GLI2_HUMAN
θ value	1.06291 (rank : 984)	NC score	-0.013881 (rank : 1629)
Query Neighborhood Hits	1407	Target Neighborhood Hits	971	Shared Neighborhood Hits	136
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

HDAC6_MOUSE
θ value	1.06291 (rank : 985)	NC score	0.000918 (rank : 1547)
Query Neighborhood Hits	1407	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

INVS_MOUSE
θ value	1.06291 (rank : 986)	NC score	0.029132 (rank : 1251)
Query Neighborhood Hits	1407	Target Neighborhood Hits	609	Shared Neighborhood Hits	127
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

LAD1_MOUSE
θ value	1.06291 (rank : 987)	NC score	0.038178 (rank : 1177)
Query Neighborhood Hits	1407	Target Neighborhood Hits	391	Shared Neighborhood Hits	113
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

MD1L1_HUMAN
θ value	1.06291 (rank : 988)	NC score	0.022532 (rank : 1299)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MKL1_MOUSE
θ value	1.06291 (rank : 989)	NC score	0.041836 (rank : 1161)
Query Neighborhood Hits	1407	Target Neighborhood Hits	667	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MLL4_HUMAN
θ value	1.06291 (rank : 990)	NC score	0.057846 (rank : 1046)
Query Neighborhood Hits	1407	Target Neighborhood Hits	722	Shared Neighborhood Hits	259
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MNT_MOUSE
θ value	1.06291 (rank : 991)	NC score	0.061395 (rank : 1023)
Query Neighborhood Hits	1407	Target Neighborhood Hits	432	Shared Neighborhood Hits	171
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NFAC4_HUMAN
θ value	1.06291 (rank : 992)	NC score	0.016876 (rank : 1352)
Query Neighborhood Hits	1407	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

OBF1_HUMAN
θ value	1.06291 (rank : 993)	NC score	0.037586 (rank : 1182)
Query Neighborhood Hits	1407	Target Neighborhood Hits	203	Shared Neighborhood Hits	103
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

PHF8_HUMAN
θ value	1.06291 (rank : 994)	NC score	0.003898 (rank : 1503)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

PRD16_HUMAN
θ value	1.06291 (rank : 995)	NC score	-0.018403 (rank : 1641)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

PRGR_MOUSE
θ value	1.06291 (rank : 996)	NC score	0.000158 (rank : 1560)
Query Neighborhood Hits	1407	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SC24A_MOUSE
θ value	1.06291 (rank : 997)	NC score	0.042558 (rank : 1153)
Query Neighborhood Hits	1407	Target Neighborhood Hits	394	Shared Neighborhood Hits	143
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SIP1_HUMAN
θ value	1.06291 (rank : 998)	NC score	-0.019009 (rank : 1647)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	68
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

SOX8_HUMAN
θ value	1.06291 (rank : 999)	NC score	0.002808 (rank : 1519)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

SRRM2_HUMAN
θ value	1.06291 (rank : 1000)	NC score	0.090757 (rank : 896)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1296	Shared Neighborhood Hits	339
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TTLL5_MOUSE
θ value	1.06291 (rank : 1001)	NC score	0.010562 (rank : 1414)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

ZBT16_HUMAN
θ value	1.06291 (rank : 1002)	NC score	-0.022277 (rank : 1656)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1010	Shared Neighborhood Hits	96
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

ZBT45_HUMAN
θ value	1.06291 (rank : 1003)	NC score	-0.016817 (rank : 1637)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	121
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

ABTAP_MOUSE
θ value	1.38821 (rank : 1004)	NC score	0.019943 (rank : 1324)
Query Neighborhood Hits	1407	Target Neighborhood Hits	381	Shared Neighborhood Hits	50
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

ASTL_HUMAN
θ value	1.38821 (rank : 1005)	NC score	0.021658 (rank : 1308)
Query Neighborhood Hits	1407	Target Neighborhood Hits	252	Shared Neighborhood Hits	97
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

CELR1_MOUSE
θ value	1.38821 (rank : 1006)	NC score	-0.013317 (rank : 1627)
Query Neighborhood Hits	1407	Target Neighborhood Hits	617	Shared Neighborhood Hits	42
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

CN155_HUMAN
θ value	1.38821 (rank : 1007)	NC score	0.089993 (rank : 898)
Query Neighborhood Hits	1407	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

COBA1_HUMAN
θ value	1.38821 (rank : 1008)	NC score	0.014764 (rank : 1370)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	124
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CRSP2_HUMAN
θ value	1.38821 (rank : 1009)	NC score	0.044866 (rank : 1145)
Query Neighborhood Hits	1407	Target Neighborhood Hits	380	Shared Neighborhood Hits	142
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

EGR3_HUMAN
θ value	1.38821 (rank : 1010)	NC score	-0.018543 (rank : 1643)
Query Neighborhood Hits	1407	Target Neighborhood Hits	746	Shared Neighborhood Hits	63
SwissProt Accessions	Q06889	Gene names	EGR3, PILOT
Domain Architecture	No domain graphic available
Description	Early growth response protein 3 (EGR-3) (Zinc finger protein pilot).

EGR3_MOUSE
θ value	1.38821 (rank : 1011)	NC score	-0.018530 (rank : 1642)
Query Neighborhood Hits	1407	Target Neighborhood Hits	747	Shared Neighborhood Hits	63
SwissProt Accessions	P43300, Q9R276	Gene names	Egr3, Egr-3
Domain Architecture
Description	Early growth response protein 3 (EGR-3).

ENAH_MOUSE
θ value	1.38821 (rank : 1012)	NC score	0.087621 (rank : 911)
Query Neighborhood Hits	1407	Target Neighborhood Hits	919	Shared Neighborhood Hits	298
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

FA47A_HUMAN
θ value	1.38821 (rank : 1013)	NC score	0.050804 (rank : 1118)
Query Neighborhood Hits	1407	Target Neighborhood Hits	451	Shared Neighborhood Hits	157
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FRM4B_HUMAN
θ value	1.38821 (rank : 1014)	NC score	0.000425 (rank : 1557)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

GLIS3_MOUSE
θ value	1.38821 (rank : 1015)	NC score	-0.014543 (rank : 1631)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	109
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

GP152_MOUSE
θ value	1.38821 (rank : 1016)	NC score	0.003126 (rank : 1514)
Query Neighborhood Hits	1407	Target Neighborhood Hits	607	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

GRIN1_MOUSE
θ value	1.38821 (rank : 1017)	NC score	0.042213 (rank : 1157)
Query Neighborhood Hits	1407	Target Neighborhood Hits	337	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HSF1_MOUSE
θ value	1.38821 (rank : 1018)	NC score	0.022842 (rank : 1296)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	91
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IF4G1_MOUSE
θ value	1.38821 (rank : 1019)	NC score	0.030684 (rank : 1235)
Query Neighborhood Hits	1407	Target Neighborhood Hits	534	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

IQEC2_HUMAN
θ value	1.38821 (rank : 1020)	NC score	0.029917 (rank : 1243)
Query Neighborhood Hits	1407	Target Neighborhood Hits	403	Shared Neighborhood Hits	149
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

K0310_HUMAN
θ value	1.38821 (rank : 1021)	NC score	0.056515 (rank : 1061)
Query Neighborhood Hits	1407	Target Neighborhood Hits	420	Shared Neighborhood Hits	164
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

K1543_HUMAN
θ value	1.38821 (rank : 1022)	NC score	0.042550 (rank : 1154)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MAGD4_HUMAN
θ value	1.38821 (rank : 1023)	NC score	0.020124 (rank : 1322)
Query Neighborhood Hits	1407	Target Neighborhood Hits	338	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

MNT_HUMAN
θ value	1.38821 (rank : 1024)	NC score	0.059758 (rank : 1033)
Query Neighborhood Hits	1407	Target Neighborhood Hits	496	Shared Neighborhood Hits	197
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MUC5B_HUMAN
θ value	1.38821 (rank : 1025)	NC score	0.042110 (rank : 1159)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	216
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MUCDL_HUMAN
θ value	1.38821 (rank : 1026)	NC score	0.043401 (rank : 1149)
Query Neighborhood Hits	1407	Target Neighborhood Hits	777	Shared Neighborhood Hits	225
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NAB2_MOUSE
θ value	1.38821 (rank : 1027)	NC score	0.006776 (rank : 1474)
Query Neighborhood Hits	1407	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61127	Gene names	Nab2
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2).

NECP2_MOUSE
θ value	1.38821 (rank : 1028)	NC score	0.007724 (rank : 1461)
Query Neighborhood Hits	1407	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1J1, Q3U1M1, Q9CV41	Gene names	Necap2
Domain Architecture	No domain graphic available
Description	Adaptin ear-binding coat-associated protein 2 (NECAP-2).

PCOC1_HUMAN
θ value	1.38821 (rank : 1029)	NC score	-0.001661 (rank : 1580)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PKNX2_MOUSE
θ value	1.38821 (rank : 1030)	NC score	0.004546 (rank : 1499)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BG99, Q8R4B0	Gene names	Pknox2, Prep2
Domain Architecture	No domain graphic available
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

RERE_HUMAN
θ value	1.38821 (rank : 1031)	NC score	0.080443 (rank : 929)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	293
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RERE_MOUSE
θ value	1.38821 (rank : 1032)	NC score	0.083608 (rank : 921)
Query Neighborhood Hits	1407	Target Neighborhood Hits	785	Shared Neighborhood Hits	283
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RP3A_HUMAN
θ value	1.38821 (rank : 1033)	NC score	0.028279 (rank : 1256)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	1.38821 (rank : 1034)	NC score	0.029030 (rank : 1252)
Query Neighborhood Hits	1407	Target Neighborhood Hits	510	Shared Neighborhood Hits	153
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SAV1_MOUSE
θ value	1.38821 (rank : 1035)	NC score	0.005462 (rank : 1487)
Query Neighborhood Hits	1407	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SETBP_HUMAN
θ value	1.38821 (rank : 1036)	NC score	0.033845 (rank : 1208)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SHAN1_HUMAN
θ value	1.38821 (rank : 1037)	NC score	0.067734 (rank : 983)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1041	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SNPC4_HUMAN
θ value	1.38821 (rank : 1038)	NC score	0.055234 (rank : 1071)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	192
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SOX30_MOUSE
θ value	1.38821 (rank : 1039)	NC score	0.019103 (rank : 1332)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

TACC3_HUMAN
θ value	1.38821 (rank : 1040)	NC score	0.021268 (rank : 1309)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TGIF_HUMAN
θ value	1.38821 (rank : 1041)	NC score	0.001076 (rank : 1545)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	Q15583, Q6ICR0, Q8N5X9, Q9NRS0	Gene names	TGIF
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

UBP31_HUMAN
θ value	1.38821 (rank : 1042)	NC score	0.013904 (rank : 1382)
Query Neighborhood Hits	1407	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

UBXD3_MOUSE
θ value	1.38821 (rank : 1043)	NC score	0.010491 (rank : 1417)
Query Neighborhood Hits	1407	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

ZFHX2_HUMAN
θ value	1.38821 (rank : 1044)	NC score	-0.002323 (rank : 1588)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1178	Shared Neighborhood Hits	161
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ZN692_MOUSE
θ value	1.38821 (rank : 1045)	NC score	-0.019436 (rank : 1648)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

AFF4_HUMAN
θ value	1.81305 (rank : 1046)	NC score	0.030036 (rank : 1241)
Query Neighborhood Hits	1407	Target Neighborhood Hits	611	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AKA10_HUMAN
θ value	1.81305 (rank : 1047)	NC score	0.011058 (rank : 1409)
Query Neighborhood Hits	1407	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

ATX1_HUMAN
θ value	1.81305 (rank : 1048)	NC score	0.012646 (rank : 1392)
Query Neighborhood Hits	1407	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	P54253, Q9UJG2, Q9Y4J1	Gene names	ATXN1, ATX1, SCA1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein).

BUB1_MOUSE
θ value	1.81305 (rank : 1049)	NC score	0.539814 (rank : 817)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	498
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CA106_HUMAN
θ value	1.81305 (rank : 1050)	NC score	0.020727 (rank : 1315)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	45
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CEA19_HUMAN
θ value	1.81305 (rank : 1051)	NC score	0.005769 (rank : 1485)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

CEP72_HUMAN
θ value	1.81305 (rank : 1052)	NC score	0.008025 (rank : 1452)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CIZ1_HUMAN
θ value	1.81305 (rank : 1053)	NC score	0.050496 (rank : 1122)
Query Neighborhood Hits	1407	Target Neighborhood Hits	359	Shared Neighborhood Hits	108
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

CO9A1_HUMAN
θ value	1.81305 (rank : 1054)	NC score	0.009969 (rank : 1424)
Query Neighborhood Hits	1407	Target Neighborhood Hits	420	Shared Neighborhood Hits	100
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CR025_HUMAN
θ value	1.81305 (rank : 1055)	NC score	0.009568 (rank : 1428)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q96B23, Q5XG78, Q6N058, Q86TB5, Q8TCQ5	Gene names	C18orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf25.

CT055_MOUSE
θ value	1.81305 (rank : 1056)	NC score	0.022134 (rank : 1303)
Query Neighborhood Hits	1407	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R184, Q8BQE5, Q8K024, Q8VEM7, Q9CU80	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55 homolog.

DNM3A_MOUSE
θ value	1.81305 (rank : 1057)	NC score	0.007107 (rank : 1470)
Query Neighborhood Hits	1407	Target Neighborhood Hits	91	Shared Neighborhood Hits	31
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

DSCL1_HUMAN
θ value	1.81305 (rank : 1058)	NC score	0.046623 (rank : 1138)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

FRM4B_MOUSE
θ value	1.81305 (rank : 1059)	NC score	0.001329 (rank : 1543)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

GLIS1_MOUSE
θ value	1.81305 (rank : 1060)	NC score	-0.017838 (rank : 1640)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).

HGS_MOUSE
θ value	1.81305 (rank : 1061)	NC score	0.027258 (rank : 1267)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	157
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IF31_HUMAN
θ value	1.81305 (rank : 1062)	NC score	0.014055 (rank : 1379)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75822, Q9BUD2, Q9H8Q2, Q9UI65	Gene names	EIF3S1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j).

IQEC2_MOUSE
θ value	1.81305 (rank : 1063)	NC score	0.030127 (rank : 1239)
Query Neighborhood Hits	1407	Target Neighborhood Hits	417	Shared Neighborhood Hits	152
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IRAK3_HUMAN
θ value	1.81305 (rank : 1064)	NC score	0.688940 (rank : 741)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	593
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MAP4_MOUSE
θ value	1.81305 (rank : 1065)	NC score	0.058319 (rank : 1045)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	139
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MDFI_HUMAN
θ value	1.81305 (rank : 1066)	NC score	0.012220 (rank : 1400)
Query Neighborhood Hits	1407	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

MTSS1_HUMAN
θ value	1.81305 (rank : 1067)	NC score	0.039599 (rank : 1171)
Query Neighborhood Hits	1407	Target Neighborhood Hits	504	Shared Neighborhood Hits	131
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

NUP53_HUMAN
θ value	1.81305 (rank : 1068)	NC score	0.021697 (rank : 1307)
Query Neighborhood Hits	1407	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

NUP98_HUMAN
θ value	1.81305 (rank : 1069)	NC score	0.012237 (rank : 1399)
Query Neighborhood Hits	1407	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

PCD16_HUMAN
θ value	1.81305 (rank : 1070)	NC score	-0.006671 (rank : 1606)
Query Neighborhood Hits	1407	Target Neighborhood Hits	245	Shared Neighborhood Hits	35
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

PCDGK_HUMAN
θ value	1.81305 (rank : 1071)	NC score	-0.009012 (rank : 1616)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UN70, O60622, Q08192, Q9Y5C4	Gene names	PCDHGC3, PCDH2
Domain Architecture
Description	Protocadherin gamma C3 precursor (PCDH-gamma-C3) (Protocadherin 43) (PC-43) (Protocadherin 2).

PCDH8_HUMAN
θ value	1.81305 (rank : 1072)	NC score	-0.008126 (rank : 1612)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	15
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

PTTG1_MOUSE
θ value	1.81305 (rank : 1073)	NC score	0.008544 (rank : 1441)
Query Neighborhood Hits	1407	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

PUNC_MOUSE
θ value	1.81305 (rank : 1074)	NC score	0.034109 (rank : 1205)
Query Neighborhood Hits	1407	Target Neighborhood Hits	501	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

RTEL1_HUMAN
θ value	1.81305 (rank : 1075)	NC score	0.006877 (rank : 1473)
Query Neighborhood Hits	1407	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

RUSC2_MOUSE
θ value	1.81305 (rank : 1076)	NC score	0.025895 (rank : 1273)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	112
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SF3B4_HUMAN
θ value	1.81305 (rank : 1077)	NC score	0.017299 (rank : 1349)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	130
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

SOX17_MOUSE
θ value	1.81305 (rank : 1078)	NC score	0.011538 (rank : 1408)
Query Neighborhood Hits	1407	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

SRBP1_MOUSE
θ value	1.81305 (rank : 1079)	NC score	0.032254 (rank : 1220)
Query Neighborhood Hits	1407	Target Neighborhood Hits	384	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TP53B_MOUSE
θ value	1.81305 (rank : 1080)	NC score	0.042573 (rank : 1152)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	166
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ZN598_HUMAN
θ value	1.81305 (rank : 1081)	NC score	0.034318 (rank : 1201)
Query Neighborhood Hits	1407	Target Neighborhood Hits	339	Shared Neighborhood Hits	97
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

ABTAP_HUMAN
θ value	2.36792 (rank : 1082)	NC score	0.017759 (rank : 1346)
Query Neighborhood Hits	1407	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

ARI1B_HUMAN
θ value	2.36792 (rank : 1083)	NC score	0.053722 (rank : 1091)
Query Neighborhood Hits	1407	Target Neighborhood Hits	567	Shared Neighborhood Hits	189
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

ARID2_HUMAN
θ value	2.36792 (rank : 1084)	NC score	0.040190 (rank : 1166)
Query Neighborhood Hits	1407	Target Neighborhood Hits	302	Shared Neighborhood Hits	90
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

ASPP1_MOUSE
θ value	2.36792 (rank : 1085)	NC score	0.062912 (rank : 1013)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1244	Shared Neighborhood Hits	272
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASXL1_HUMAN
θ value	2.36792 (rank : 1086)	NC score	0.016278 (rank : 1357)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

ATX2_MOUSE
θ value	2.36792 (rank : 1087)	NC score	0.051075 (rank : 1114)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	177
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

BCL7C_MOUSE
θ value	2.36792 (rank : 1088)	NC score	0.014425 (rank : 1375)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

BRD2_HUMAN
θ value	2.36792 (rank : 1089)	NC score	0.010413 (rank : 1421)
Query Neighborhood Hits	1407	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

CAC1G_HUMAN
θ value	2.36792 (rank : 1090)	NC score	0.013919 (rank : 1381)
Query Neighborhood Hits	1407	Target Neighborhood Hits	587	Shared Neighborhood Hits	164
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CDN1C_MOUSE
θ value	2.36792 (rank : 1091)	NC score	0.023603 (rank : 1292)
Query Neighborhood Hits	1407	Target Neighborhood Hits	161	Shared Neighborhood Hits	53
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CN004_HUMAN
θ value	2.36792 (rank : 1092)	NC score	0.021149 (rank : 1311)
Query Neighborhood Hits	1407	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

CO3A1_MOUSE
θ value	2.36792 (rank : 1093)	NC score	0.025759 (rank : 1276)
Query Neighborhood Hits	1407	Target Neighborhood Hits	466	Shared Neighborhood Hits	134
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO7A1_HUMAN
θ value	2.36792 (rank : 1094)	NC score	0.022199 (rank : 1302)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	196
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

COEA1_MOUSE
θ value	2.36792 (rank : 1095)	NC score	0.007769 (rank : 1460)
Query Neighborhood Hits	1407	Target Neighborhood Hits	402	Shared Neighborhood Hits	93
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

COG8_MOUSE
θ value	2.36792 (rank : 1096)	NC score	0.012571 (rank : 1393)
Query Neighborhood Hits	1407	Target Neighborhood Hits	147	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

COIA1_HUMAN
θ value	2.36792 (rank : 1097)	NC score	0.026252 (rank : 1271)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	157
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CP250_HUMAN
θ value	2.36792 (rank : 1098)	NC score	0.020166 (rank : 1320)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1805	Shared Neighborhood Hits	155
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CS007_MOUSE
θ value	2.36792 (rank : 1099)	NC score	0.045713 (rank : 1140)
Query Neighborhood Hits	1407	Target Neighborhood Hits	464	Shared Neighborhood Hits	158
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

CTND2_HUMAN
θ value	2.36792 (rank : 1100)	NC score	0.017809 (rank : 1344)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CYLD_MOUSE
θ value	2.36792 (rank : 1101)	NC score	0.003969 (rank : 1502)
Query Neighborhood Hits	1407	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

DMN_HUMAN
θ value	2.36792 (rank : 1102)	NC score	0.002215 (rank : 1529)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	85
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

EMSY_HUMAN
θ value	2.36792 (rank : 1103)	NC score	0.042116 (rank : 1158)
Query Neighborhood Hits	1407	Target Neighborhood Hits	296	Shared Neighborhood Hits	94
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

EP400_HUMAN
θ value	2.36792 (rank : 1104)	NC score	0.040166 (rank : 1167)
Query Neighborhood Hits	1407	Target Neighborhood Hits	556	Shared Neighborhood Hits	217
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FA8A1_HUMAN
θ value	2.36792 (rank : 1105)	NC score	0.019031 (rank : 1333)
Query Neighborhood Hits	1407	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBU6	Gene names	FAM8A1, AHCP
Domain Architecture	No domain graphic available
Description	Protein FAM8A1 (Autosomal highly conserved protein).

GAK12_HUMAN
θ value	2.36792 (rank : 1106)	NC score	0.017789 (rank : 1345)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	119
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HCLS1_HUMAN
θ value	2.36792 (rank : 1107)	NC score	0.048018 (rank : 1136)
Query Neighborhood Hits	1407	Target Neighborhood Hits	358	Shared Neighborhood Hits	118
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HELZ_HUMAN
θ value	2.36792 (rank : 1108)	NC score	0.012082 (rank : 1403)
Query Neighborhood Hits	1407	Target Neighborhood Hits	198	Shared Neighborhood Hits	58
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

HXA3_HUMAN
θ value	2.36792 (rank : 1109)	NC score	0.002684 (rank : 1522)
Query Neighborhood Hits	1407	Target Neighborhood Hits	535	Shared Neighborhood Hits	139
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

IL3B2_MOUSE
θ value	2.36792 (rank : 1110)	NC score	0.031357 (rank : 1232)
Query Neighborhood Hits	1407	Target Neighborhood Hits	372	Shared Neighborhood Hits	132
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

IL3RB_MOUSE
θ value	2.36792 (rank : 1111)	NC score	0.029342 (rank : 1248)
Query Neighborhood Hits	1407	Target Neighborhood Hits	355	Shared Neighborhood Hits	121
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

KCNH6_HUMAN
θ value	2.36792 (rank : 1112)	NC score	0.008556 (rank : 1440)
Query Neighborhood Hits	1407	Target Neighborhood Hits	222	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KI67_HUMAN
θ value	2.36792 (rank : 1113)	NC score	0.031589 (rank : 1226)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	107
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

MAGB6_HUMAN
θ value	2.36792 (rank : 1114)	NC score	0.012247 (rank : 1398)
Query Neighborhood Hits	1407	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MUC2_HUMAN
θ value	2.36792 (rank : 1115)	NC score	0.064857 (rank : 999)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	257
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NPAS4_MOUSE
θ value	2.36792 (rank : 1116)	NC score	0.028996 (rank : 1253)
Query Neighborhood Hits	1407	Target Neighborhood Hits	245	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

OGFR_MOUSE
θ value	2.36792 (rank : 1117)	NC score	0.032143 (rank : 1221)
Query Neighborhood Hits	1407	Target Neighborhood Hits	584	Shared Neighborhood Hits	137
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PF21A_MOUSE
θ value	2.36792 (rank : 1118)	NC score	0.019224 (rank : 1330)
Query Neighborhood Hits	1407	Target Neighborhood Hits	285	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

PLCB4_HUMAN
θ value	2.36792 (rank : 1119)	NC score	0.031586 (rank : 1227)
Query Neighborhood Hits	1407	Target Neighborhood Hits	658	Shared Neighborhood Hits	82
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PTN13_MOUSE
θ value	2.36792 (rank : 1120)	NC score	-0.002683 (rank : 1589)
Query Neighborhood Hits	1407	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RASF7_MOUSE
θ value	2.36792 (rank : 1121)	NC score	0.010004 (rank : 1423)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DD19	Gene names	Rassf7
Domain Architecture
Description	Ras association domain-containing protein 7.

SALL3_HUMAN
θ value	2.36792 (rank : 1122)	NC score	-0.006371 (rank : 1603)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1066	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SETBP_MOUSE
θ value	2.36792 (rank : 1123)	NC score	0.029185 (rank : 1249)
Query Neighborhood Hits	1407	Target Neighborhood Hits	352	Shared Neighborhood Hits	117
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SRTD1_MOUSE
θ value	2.36792 (rank : 1124)	NC score	0.008690 (rank : 1438)
Query Neighborhood Hits	1407	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

SYNP2_HUMAN
θ value	2.36792 (rank : 1125)	NC score	0.022249 (rank : 1301)
Query Neighborhood Hits	1407	Target Neighborhood Hits	323	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TENN_HUMAN
θ value	2.36792 (rank : 1126)	NC score	0.000397 (rank : 1559)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

XYLT2_HUMAN
θ value	2.36792 (rank : 1127)	NC score	0.003820 (rank : 1505)
Query Neighborhood Hits	1407	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H1B5, Q6UY41, Q86V00	Gene names	XYLT2, XT2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (xylT-II) (XT-II) (Peptide O-xylosyltransferase 1).

ZC3H6_MOUSE
θ value	2.36792 (rank : 1128)	NC score	0.012842 (rank : 1391)
Query Neighborhood Hits	1407	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ZIC5_HUMAN
θ value	2.36792 (rank : 1129)	NC score	-0.016216 (rank : 1634)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	88
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZIMP7_MOUSE
θ value	2.36792 (rank : 1130)	NC score	0.033883 (rank : 1207)
Query Neighborhood Hits	1407	Target Neighborhood Hits	566	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

BCL9_MOUSE
θ value	3.0926 (rank : 1131)	NC score	0.064606 (rank : 1000)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	258
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BTBDC_HUMAN
θ value	3.0926 (rank : 1132)	NC score	0.024126 (rank : 1287)
Query Neighborhood Hits	1407	Target Neighborhood Hits	248	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CAR10_HUMAN
θ value	3.0926 (rank : 1133)	NC score	0.010447 (rank : 1419)
Query Neighborhood Hits	1407	Target Neighborhood Hits	569	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CB010_HUMAN
θ value	3.0926 (rank : 1134)	NC score	0.020403 (rank : 1316)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

CO1A2_MOUSE
θ value	3.0926 (rank : 1135)	NC score	0.015536 (rank : 1360)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	109
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CP007_MOUSE
θ value	3.0926 (rank : 1136)	NC score	0.014581 (rank : 1373)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

CS007_HUMAN
θ value	3.0926 (rank : 1137)	NC score	0.038307 (rank : 1176)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

DAZP2_MOUSE
θ value	3.0926 (rank : 1138)	NC score	0.010760 (rank : 1410)
Query Neighborhood Hits	1407	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DCP9, O88675, Q3UVI4	Gene names	Dazap2, Prtb
Domain Architecture	No domain graphic available
Description	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich protein expressed in brain).

ETV5_MOUSE
θ value	3.0926 (rank : 1139)	NC score	0.008449 (rank : 1442)
Query Neighborhood Hits	1407	Target Neighborhood Hits	328	Shared Neighborhood Hits	105
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

EVL_HUMAN
θ value	3.0926 (rank : 1140)	NC score	0.024719 (rank : 1285)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

GNDS_HUMAN
θ value	3.0926 (rank : 1141)	NC score	0.021000 (rank : 1313)
Query Neighborhood Hits	1407	Target Neighborhood Hits	201	Shared Neighborhood Hits	84
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

HPS4_MOUSE
θ value	3.0926 (rank : 1142)	NC score	0.021166 (rank : 1310)
Query Neighborhood Hits	1407	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q99KG7	Gene names	Hps4, Le
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein homolog (Light-ear protein) (Le protein).

JADE2_HUMAN
θ value	3.0926 (rank : 1143)	NC score	0.010157 (rank : 1422)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

KLF10_HUMAN
θ value	3.0926 (rank : 1144)	NC score	-0.017062 (rank : 1638)
Query Neighborhood Hits	1407	Target Neighborhood Hits	744	Shared Neighborhood Hits	72
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

MEGF9_MOUSE
θ value	3.0926 (rank : 1145)	NC score	0.026303 (rank : 1270)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MISS_MOUSE
θ value	3.0926 (rank : 1146)	NC score	0.058833 (rank : 1040)
Query Neighborhood Hits	1407	Target Neighborhood Hits	444	Shared Neighborhood Hits	181
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MTSS1_MOUSE
θ value	3.0926 (rank : 1147)	NC score	0.039226 (rank : 1174)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	176
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

NOTC2_MOUSE
θ value	3.0926 (rank : 1148)	NC score	0.000813 (rank : 1550)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	131
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PARP4_HUMAN
θ value	3.0926 (rank : 1149)	NC score	0.008249 (rank : 1447)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

PELP1_MOUSE
θ value	3.0926 (rank : 1150)	NC score	0.061820 (rank : 1018)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	230
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PI5PA_MOUSE
θ value	3.0926 (rank : 1151)	NC score	0.057211 (rank : 1051)
Query Neighborhood Hits	1407	Target Neighborhood Hits	331	Shared Neighborhood Hits	167
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PINK1_MOUSE
θ value	3.0926 (rank : 1152)	NC score	0.734058 (rank : 655)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	668
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RTP3_MOUSE
θ value	3.0926 (rank : 1153)	NC score	0.040687 (rank : 1164)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	141
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SIX5_HUMAN
θ value	3.0926 (rank : 1154)	NC score	0.015130 (rank : 1366)
Query Neighborhood Hits	1407	Target Neighborhood Hits	386	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

SMOO_HUMAN
θ value	3.0926 (rank : 1155)	NC score	0.034727 (rank : 1200)
Query Neighborhood Hits	1407	Target Neighborhood Hits	391	Shared Neighborhood Hits	150
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SYNG_HUMAN
θ value	3.0926 (rank : 1156)	NC score	0.009859 (rank : 1427)
Query Neighborhood Hits	1407	Target Neighborhood Hits	160	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

TAF4_HUMAN
θ value	3.0926 (rank : 1157)	NC score	0.097854 (rank : 885)
Query Neighborhood Hits	1407	Target Neighborhood Hits	687	Shared Neighborhood Hits	251
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TLE1_MOUSE
θ value	3.0926 (rank : 1158)	NC score	-0.005114 (rank : 1601)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	81
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

TMEM8_HUMAN
θ value	3.0926 (rank : 1159)	NC score	0.005461 (rank : 1488)
Query Neighborhood Hits	1407	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCN3, Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9	Gene names	TMEM8
Domain Architecture	No domain graphic available
Description	Transmembrane protein 8 precursor (M83 protein).

TRI66_HUMAN
θ value	3.0926 (rank : 1160)	NC score	0.031541 (rank : 1228)
Query Neighborhood Hits	1407	Target Neighborhood Hits	479	Shared Neighborhood Hits	139
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TTBK1_HUMAN
θ value	3.0926 (rank : 1161)	NC score	0.683131 (rank : 750)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	745
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

ZAR1_MOUSE
θ value	3.0926 (rank : 1162)	NC score	0.025761 (rank : 1275)
Query Neighborhood Hits	1407	Target Neighborhood Hits	254	Shared Neighborhood Hits	66
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZDH14_MOUSE
θ value	3.0926 (rank : 1163)	NC score	-0.000416 (rank : 1564)
Query Neighborhood Hits	1407	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BQQ1, Q8BNR2, Q8CFN0	Gene names	Zdhhc14
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP).

ZYX_HUMAN
θ value	3.0926 (rank : 1164)	NC score	0.032750 (rank : 1215)
Query Neighborhood Hits	1407	Target Neighborhood Hits	387	Shared Neighborhood Hits	128
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

BCAR1_HUMAN
θ value	4.03905 (rank : 1165)	NC score	0.049307 (rank : 1131)
Query Neighborhood Hits	1407	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

C1QT5_HUMAN
θ value	4.03905 (rank : 1166)	NC score	0.000571 (rank : 1554)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BXJ0, Q8N6P2, Q9UFX4	Gene names	C1QTNF5, CTRP5
Domain Architecture
Description	Complement C1q tumor necrosis factor-related protein 5 precursor.

CA106_MOUSE
θ value	4.03905 (rank : 1167)	NC score	0.018171 (rank : 1338)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CCD91_MOUSE
θ value	4.03905 (rank : 1168)	NC score	0.016422 (rank : 1355)
Query Neighborhood Hits	1407	Target Neighborhood Hits	699	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CR025_MOUSE
θ value	4.03905 (rank : 1169)	NC score	0.008920 (rank : 1433)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BH50, Q3TQ72, Q8BU43	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf25 homolog.

CUTL1_HUMAN
θ value	4.03905 (rank : 1170)	NC score	0.015331 (rank : 1363)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1574	Shared Neighborhood Hits	203
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	4.03905 (rank : 1171)	NC score	0.018767 (rank : 1334)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1620	Shared Neighborhood Hits	222
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

DDX51_HUMAN
θ value	4.03905 (rank : 1172)	NC score	-0.001327 (rank : 1578)
Query Neighborhood Hits	1407	Target Neighborhood Hits	332	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DEMA_MOUSE
θ value	4.03905 (rank : 1173)	NC score	0.001817 (rank : 1531)
Query Neighborhood Hits	1407	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV69	Gene names	Epb49, Epb4.9
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

DLX4_HUMAN
θ value	4.03905 (rank : 1174)	NC score	-0.011499 (rank : 1621)
Query Neighborhood Hits	1407	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q92988, O60480, Q13265, Q6PJK0, Q9HBE0	Gene names	DLX4, BP1, DLX7, DLX8
Domain Architecture	No domain graphic available
Description	Homeobox protein DLX-4 (DLX-7) (DLX-8) (Beta protein 1).

EVX1_HUMAN
θ value	4.03905 (rank : 1175)	NC score	-0.012598 (rank : 1624)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

FLRT2_HUMAN
θ value	4.03905 (rank : 1176)	NC score	-0.006703 (rank : 1607)
Query Neighborhood Hits	1407	Target Neighborhood Hits	295	Shared Neighborhood Hits	27
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

FMN2_MOUSE
θ value	4.03905 (rank : 1177)	NC score	0.049866 (rank : 1129)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

GGA3_HUMAN
θ value	4.03905 (rank : 1178)	NC score	0.008888 (rank : 1434)
Query Neighborhood Hits	1407	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

GMIP_MOUSE
θ value	4.03905 (rank : 1179)	NC score	0.011940 (rank : 1405)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

IF35_MOUSE
θ value	4.03905 (rank : 1180)	NC score	0.040710 (rank : 1163)
Query Neighborhood Hits	1407	Target Neighborhood Hits	210	Shared Neighborhood Hits	111
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IL4RA_MOUSE
θ value	4.03905 (rank : 1181)	NC score	0.012501 (rank : 1395)
Query Neighborhood Hits	1407	Target Neighborhood Hits	194	Shared Neighborhood Hits	65
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

IRF7_MOUSE
θ value	4.03905 (rank : 1182)	NC score	-0.000050 (rank : 1562)
Query Neighborhood Hits	1407	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P70434	Gene names	Irf7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

LARP4_MOUSE
θ value	4.03905 (rank : 1183)	NC score	0.021145 (rank : 1312)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

MAGI2_MOUSE
θ value	4.03905 (rank : 1184)	NC score	0.013704 (rank : 1384)
Query Neighborhood Hits	1407	Target Neighborhood Hits	370	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAVS_MOUSE
θ value	4.03905 (rank : 1185)	NC score	0.023372 (rank : 1293)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

MAZ_HUMAN
θ value	4.03905 (rank : 1186)	NC score	-0.019934 (rank : 1650)
Query Neighborhood Hits	1407	Target Neighborhood Hits	757	Shared Neighborhood Hits	71
SwissProt Accessions	P56270, Q15703, Q99443	Gene names	MAZ
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1) (ZF87) (ZIF87).

MORC2_HUMAN
θ value	4.03905 (rank : 1187)	NC score	0.016884 (rank : 1350)
Query Neighborhood Hits	1407	Target Neighborhood Hits	207	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

NAT6_MOUSE
θ value	4.03905 (rank : 1188)	NC score	0.014375 (rank : 1378)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

PACE1_HUMAN
θ value	4.03905 (rank : 1189)	NC score	0.087047 (rank : 913)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PANK2_HUMAN
θ value	4.03905 (rank : 1190)	NC score	0.000787 (rank : 1552)
Query Neighborhood Hits	1407	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ23, Q5T7I2, Q8N7Q4, Q8TCR5, Q9BYW5, Q9HAF2	Gene names	PANK2, C20orf48
Domain Architecture
Description	Pantothenate kinase 2, mitochondrial precursor (EC 2.7.1.33) (Pantothenic acid kinase 2) (hPANK2).

PCQAP_MOUSE
θ value	4.03905 (rank : 1191)	NC score	0.075394 (rank : 944)
Query Neighborhood Hits	1407	Target Neighborhood Hits	506	Shared Neighborhood Hits	167
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PRDM2_HUMAN
θ value	4.03905 (rank : 1192)	NC score	-0.000272 (rank : 1563)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1135	Shared Neighborhood Hits	208
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

RGS12_HUMAN
θ value	4.03905 (rank : 1193)	NC score	0.007953 (rank : 1455)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	71
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RPGR1_MOUSE
θ value	4.03905 (rank : 1194)	NC score	0.013208 (rank : 1387)
Query Neighborhood Hits	1407	Target Neighborhood Hits	713	Shared Neighborhood Hits	82
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RUNX1_MOUSE
θ value	4.03905 (rank : 1195)	NC score	0.005814 (rank : 1482)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

SOX18_HUMAN
θ value	4.03905 (rank : 1196)	NC score	0.003889 (rank : 1504)
Query Neighborhood Hits	1407	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

SRRM1_MOUSE
θ value	4.03905 (rank : 1197)	NC score	0.103234 (rank : 876)
Query Neighborhood Hits	1407	Target Neighborhood Hits	966	Shared Neighborhood Hits	292
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ST5_HUMAN
θ value	4.03905 (rank : 1198)	NC score	0.009919 (rank : 1426)
Query Neighborhood Hits	1407	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

ST5_MOUSE
θ value	4.03905 (rank : 1199)	NC score	0.009225 (rank : 1431)
Query Neighborhood Hits	1407	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

TAF9_MOUSE
θ value	4.03905 (rank : 1200)	NC score	0.008838 (rank : 1436)
Query Neighborhood Hits	1407	Target Neighborhood Hits	69	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

TAU_MOUSE
θ value	4.03905 (rank : 1201)	NC score	0.043955 (rank : 1148)
Query Neighborhood Hits	1407	Target Neighborhood Hits	502	Shared Neighborhood Hits	182
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TCOF_MOUSE
θ value	4.03905 (rank : 1202)	NC score	0.061157 (rank : 1024)
Query Neighborhood Hits	1407	Target Neighborhood Hits	471	Shared Neighborhood Hits	137
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TMPSD_HUMAN
θ value	4.03905 (rank : 1203)	NC score	-0.006926 (rank : 1608)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TSH3_HUMAN
θ value	4.03905 (rank : 1204)	NC score	-0.006400 (rank : 1604)
Query Neighborhood Hits	1407	Target Neighborhood Hits	564	Shared Neighborhood Hits	41
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

VMDL1_HUMAN
θ value	4.03905 (rank : 1205)	NC score	0.001550 (rank : 1539)
Query Neighborhood Hits	1407	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFU1, Q9NXP0	Gene names	VMD2L1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

WBS14_HUMAN
θ value	4.03905 (rank : 1206)	NC score	0.050865 (rank : 1117)
Query Neighborhood Hits	1407	Target Neighborhood Hits	273	Shared Neighborhood Hits	139
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ZN516_MOUSE
θ value	4.03905 (rank : 1207)	NC score	-0.013488 (rank : 1628)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1197	Shared Neighborhood Hits	202
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

AMOT_HUMAN
θ value	5.27518 (rank : 1208)	NC score	0.037629 (rank : 1181)
Query Neighborhood Hits	1407	Target Neighborhood Hits	712	Shared Neighborhood Hits	156
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

ANR11_HUMAN
θ value	5.27518 (rank : 1209)	NC score	0.035844 (rank : 1192)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1289	Shared Neighborhood Hits	209
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ATN1_HUMAN
θ value	5.27518 (rank : 1210)	NC score	0.082047 (rank : 926)
Query Neighborhood Hits	1407	Target Neighborhood Hits	676	Shared Neighborhood Hits	251
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

B3A2_MOUSE
θ value	5.27518 (rank : 1211)	NC score	-0.000622 (rank : 1568)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	23
SwissProt Accessions	P13808, Q9ES09, Q9ES10, Q9ES11, Q9ES12, Q9ES13	Gene names	Slc4a2, Ae2
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (B3RP).

BAG3_HUMAN
θ value	5.27518 (rank : 1212)	NC score	0.045701 (rank : 1141)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	136
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

CAN3_MOUSE
θ value	5.27518 (rank : 1213)	NC score	-0.004382 (rank : 1597)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

CDC7_MOUSE
θ value	5.27518 (rank : 1214)	NC score	0.630283 (rank : 794)
Query Neighborhood Hits	1407	Target Neighborhood Hits	641	Shared Neighborhood Hits	583
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CEP68_HUMAN
θ value	5.27518 (rank : 1215)	NC score	0.012343 (rank : 1397)
Query Neighborhood Hits	1407	Target Neighborhood Hits	128	Shared Neighborhood Hits	46
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CJ108_HUMAN
θ value	5.27518 (rank : 1216)	NC score	0.023678 (rank : 1289)
Query Neighborhood Hits	1407	Target Neighborhood Hits	165	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

CN004_MOUSE
θ value	5.27518 (rank : 1217)	NC score	0.018376 (rank : 1335)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

CN032_HUMAN
θ value	5.27518 (rank : 1218)	NC score	0.082793 (rank : 924)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CO4A1_HUMAN
θ value	5.27518 (rank : 1219)	NC score	0.013361 (rank : 1386)
Query Neighborhood Hits	1407	Target Neighborhood Hits	425	Shared Neighborhood Hits	120
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO5A1_HUMAN
θ value	5.27518 (rank : 1220)	NC score	0.017844 (rank : 1342)
Query Neighborhood Hits	1407	Target Neighborhood Hits	434	Shared Neighborhood Hits	129
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

DAXX_MOUSE
θ value	5.27518 (rank : 1221)	NC score	0.005770 (rank : 1484)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	26
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

DCC_HUMAN
θ value	5.27518 (rank : 1222)	NC score	0.050493 (rank : 1123)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	123
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DPOLA_MOUSE
θ value	5.27518 (rank : 1223)	NC score	0.003214 (rank : 1513)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	12
SwissProt Accessions	P33609	Gene names	Pola1, Pola
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

ELK4_HUMAN
θ value	5.27518 (rank : 1224)	NC score	0.007596 (rank : 1463)
Query Neighborhood Hits	1407	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

ENW1_HUMAN
θ value	5.27518 (rank : 1225)	NC score	0.000835 (rank : 1549)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

ETV3_HUMAN
θ value	5.27518 (rank : 1226)	NC score	0.013076 (rank : 1388)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	87
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

EVI1_MOUSE
θ value	5.27518 (rank : 1227)	NC score	-0.019640 (rank : 1649)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	75
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

FOXP4_MOUSE
θ value	5.27518 (rank : 1228)	NC score	-0.001917 (rank : 1583)
Query Neighborhood Hits	1407	Target Neighborhood Hits	211	Shared Neighborhood Hits	46
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

GOGB1_HUMAN
θ value	5.27518 (rank : 1229)	NC score	0.017387 (rank : 1348)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2297	Shared Neighborhood Hits	201
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GP178_HUMAN
θ value	5.27518 (rank : 1230)	NC score	0.009932 (rank : 1425)
Query Neighborhood Hits	1407	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2C4, Q5VTU1	Gene names	GPR178, KIAA1423
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR178.

IRX6_MOUSE
θ value	5.27518 (rank : 1231)	NC score	-0.004796 (rank : 1599)
Query Neighborhood Hits	1407	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER75	Gene names	Irx6, Irxb3
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-6 (Iroquois homeobox protein 6) (Homeodomain protein IRXB3).

IWS1_HUMAN
θ value	5.27518 (rank : 1232)	NC score	0.032488 (rank : 1217)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1241	Shared Neighborhood Hits	199
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

K0586_HUMAN
θ value	5.27518 (rank : 1233)	NC score	0.031284 (rank : 1233)
Query Neighborhood Hits	1407	Target Neighborhood Hits	311	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

KCNC3_MOUSE
θ value	5.27518 (rank : 1234)	NC score	-0.003725 (rank : 1594)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	33
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

LAT_MOUSE
θ value	5.27518 (rank : 1235)	NC score	0.007963 (rank : 1454)
Query Neighborhood Hits	1407	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O54957	Gene names	Lat
Domain Architecture	No domain graphic available
Description	Linker for activation of T-cells family member 1 (36 kDa phospho- tyrosine adapter protein) (pp36) (p36-38).

MAGD1_MOUSE
θ value	5.27518 (rank : 1236)	NC score	0.010419 (rank : 1420)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

MAZ_MOUSE
θ value	5.27518 (rank : 1237)	NC score	-0.020487 (rank : 1651)
Query Neighborhood Hits	1407	Target Neighborhood Hits	745	Shared Neighborhood Hits	64
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).

MPP9_HUMAN
θ value	5.27518 (rank : 1238)	NC score	0.006496 (rank : 1476)
Query Neighborhood Hits	1407	Target Neighborhood Hits	529	Shared Neighborhood Hits	47
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

OSBL9_HUMAN
θ value	5.27518 (rank : 1239)	NC score	0.001421 (rank : 1542)
Query Neighborhood Hits	1407	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PAX3_MOUSE
θ value	5.27518 (rank : 1240)	NC score	-0.008629 (rank : 1614)
Query Neighborhood Hits	1407	Target Neighborhood Hits	478	Shared Neighborhood Hits	60
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

PAX7_HUMAN
θ value	5.27518 (rank : 1241)	NC score	-0.010214 (rank : 1619)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	52
SwissProt Accessions	P23759	Gene names	PAX7, HUP1
Domain Architecture
Description	Paired box protein Pax-7 (HUP1).

PAX7_MOUSE
θ value	5.27518 (rank : 1242)	NC score	-0.011717 (rank : 1622)
Query Neighborhood Hits	1407	Target Neighborhood Hits	422	Shared Neighborhood Hits	38
SwissProt Accessions	P47239, Q9ES16	Gene names	Pax7, Pax-7
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-7.

PDZD2_HUMAN
θ value	5.27518 (rank : 1243)	NC score	0.025873 (rank : 1274)
Query Neighborhood Hits	1407	Target Neighborhood Hits	772	Shared Neighborhood Hits	186
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PHLB1_HUMAN
θ value	5.27518 (rank : 1244)	NC score	0.032866 (rank : 1213)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1038	Shared Neighborhood Hits	206
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PI3R4_HUMAN
θ value	5.27518 (rank : 1245)	NC score	0.327246 (rank : 842)
Query Neighborhood Hits	1407	Target Neighborhood Hits	534	Shared Neighborhood Hits	341
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PRR12_HUMAN
θ value	5.27518 (rank : 1246)	NC score	0.103668 (rank : 875)
Query Neighborhood Hits	1407	Target Neighborhood Hits	460	Shared Neighborhood Hits	236
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RNF37_HUMAN
θ value	5.27518 (rank : 1247)	NC score	0.001855 (rank : 1530)
Query Neighborhood Hits	1407	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	O94941	Gene names	UBOX5, KIAA0860, RNF37, UBCE7IP5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (U-box domain-containing protein 5).

RTN1_MOUSE
θ value	5.27518 (rank : 1248)	NC score	0.017840 (rank : 1343)
Query Neighborhood Hits	1407	Target Neighborhood Hits	189	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SEPT9_MOUSE
θ value	5.27518 (rank : 1249)	NC score	0.011722 (rank : 1406)
Query Neighborhood Hits	1407	Target Neighborhood Hits	238	Shared Neighborhood Hits	67
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

SEZ6L_HUMAN
θ value	5.27518 (rank : 1250)	NC score	0.003708 (rank : 1507)
Query Neighborhood Hits	1407	Target Neighborhood Hits	289	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

SHD_HUMAN
θ value	5.27518 (rank : 1251)	NC score	0.054405 (rank : 1084)
Query Neighborhood Hits	1407	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SNRPA_HUMAN
θ value	5.27518 (rank : 1252)	NC score	0.005461 (rank : 1489)
Query Neighborhood Hits	1407	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	P09012	Gene names	SNRPA
Domain Architecture
Description	U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1A protein) (U1-A).

SNX15_HUMAN
θ value	5.27518 (rank : 1253)	NC score	0.010500 (rank : 1416)
Query Neighborhood Hits	1407	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

SPR1B_HUMAN
θ value	5.27518 (rank : 1254)	NC score	0.027730 (rank : 1260)
Query Neighborhood Hits	1407	Target Neighborhood Hits	102	Shared Neighborhood Hits	26
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

SRBS1_MOUSE
θ value	5.27518 (rank : 1255)	NC score	0.036277 (rank : 1189)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	104
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STA5B_MOUSE
θ value	5.27518 (rank : 1256)	NC score	0.003403 (rank : 1512)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	20
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

TBX2_HUMAN
θ value	5.27518 (rank : 1257)	NC score	0.002459 (rank : 1526)
Query Neighborhood Hits	1407	Target Neighborhood Hits	195	Shared Neighborhood Hits	52
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

THSD1_MOUSE
θ value	5.27518 (rank : 1258)	NC score	0.003066 (rank : 1515)
Query Neighborhood Hits	1407	Target Neighborhood Hits	153	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TMM26_MOUSE
θ value	5.27518 (rank : 1259)	NC score	0.004079 (rank : 1500)
Query Neighborhood Hits	1407	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UP23, Q8BN94	Gene names	Tmem26
Domain Architecture	No domain graphic available
Description	Transmembrane protein 26.

UBN1_HUMAN
θ value	5.27518 (rank : 1260)	NC score	0.018335 (rank : 1337)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

VAPB_HUMAN
θ value	5.27518 (rank : 1261)	NC score	0.002500 (rank : 1525)
Query Neighborhood Hits	1407	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

ZHX2_MOUSE
θ value	5.27518 (rank : 1262)	NC score	-0.001266 (rank : 1576)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

ZN235_MOUSE
θ value	5.27518 (rank : 1263)	NC score	-0.022533 (rank : 1657)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	52
SwissProt Accessions	Q61116, Q3UKA3, Q8CE70	Gene names	Znf235, Zfp93
Domain Architecture
Description	Zinc finger protein 235 (Zinc finger protein 93) (Zfp-93).

ZN263_HUMAN
θ value	5.27518 (rank : 1264)	NC score	-0.022256 (rank : 1655)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	53
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).

ACY1_HUMAN
θ value	6.88961 (rank : 1265)	NC score	0.004783 (rank : 1494)
Query Neighborhood Hits	1407	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q03154	Gene names	ACY1
Domain Architecture
Description	Aminoacylase-1 (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) (ACY-1).

AFF2_MOUSE
θ value	6.88961 (rank : 1266)	NC score	0.022116 (rank : 1304)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

APC_MOUSE
θ value	6.88961 (rank : 1267)	NC score	0.024712 (rank : 1286)
Query Neighborhood Hits	1407	Target Neighborhood Hits	441	Shared Neighborhood Hits	100
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

ATS16_HUMAN
θ value	6.88961 (rank : 1268)	NC score	-0.008218 (rank : 1613)
Query Neighborhood Hits	1407	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

B4GN1_HUMAN
θ value	6.88961 (rank : 1269)	NC score	0.001232 (rank : 1544)
Query Neighborhood Hits	1407	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q00973	Gene names	B4GALNT1, GALGT, SIAT2
Domain Architecture
Description	Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) ((N- acetylneuraminyl)-galactosylglucosylceramide) (GM2/GD2 synthase) (GalNAc-T).

BCAR1_MOUSE
θ value	6.88961 (rank : 1270)	NC score	0.046663 (rank : 1137)
Query Neighborhood Hits	1407	Target Neighborhood Hits	438	Shared Neighborhood Hits	163
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCOR_MOUSE
θ value	6.88961 (rank : 1271)	NC score	0.017922 (rank : 1341)
Query Neighborhood Hits	1407	Target Neighborhood Hits	521	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

BPTF_HUMAN
θ value	6.88961 (rank : 1272)	NC score	0.039967 (rank : 1168)
Query Neighborhood Hits	1407	Target Neighborhood Hits	786	Shared Neighborhood Hits	179
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BRD4_HUMAN
θ value	6.88961 (rank : 1273)	NC score	0.057804 (rank : 1048)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	282
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

C1QT5_MOUSE
θ value	6.88961 (rank : 1274)	NC score	-0.000459 (rank : 1565)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K479	Gene names	C1qtnf5, Ctrp5
Domain Architecture	No domain graphic available
Description	Complement C1q tumor necrosis factor-related protein 5 precursor.

CD008_HUMAN
θ value	6.88961 (rank : 1275)	NC score	0.033216 (rank : 1211)
Query Neighborhood Hits	1407	Target Neighborhood Hits	330	Shared Neighborhood Hits	83
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

CK035_MOUSE
θ value	6.88961 (rank : 1276)	NC score	0.005893 (rank : 1480)
Query Neighborhood Hits	1407	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

CO2A1_HUMAN
θ value	6.88961 (rank : 1277)	NC score	0.014525 (rank : 1374)
Query Neighborhood Hits	1407	Target Neighborhood Hits	486	Shared Neighborhood Hits	129
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO5A1_MOUSE
θ value	6.88961 (rank : 1278)	NC score	0.017990 (rank : 1339)
Query Neighborhood Hits	1407	Target Neighborhood Hits	419	Shared Neighborhood Hits	130
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO9A1_MOUSE
θ value	6.88961 (rank : 1279)	NC score	0.008973 (rank : 1432)
Query Neighborhood Hits	1407	Target Neighborhood Hits	477	Shared Neighborhood Hits	112
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

COEA1_HUMAN
θ value	6.88961 (rank : 1280)	NC score	0.008334 (rank : 1444)
Query Neighborhood Hits	1407	Target Neighborhood Hits	427	Shared Neighborhood Hits	105
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

CS016_HUMAN
θ value	6.88961 (rank : 1281)	NC score	0.068364 (rank : 975)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DEND_MOUSE
θ value	6.88961 (rank : 1282)	NC score	0.005058 (rank : 1492)
Query Neighborhood Hits	1407	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TS7	Gene names	Ddn, Kiaa0749
Domain Architecture	No domain graphic available
Description	Dendrin.

DMRTC_HUMAN
θ value	6.88961 (rank : 1283)	NC score	0.003765 (rank : 1506)
Query Neighborhood Hits	1407	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

DX26B_MOUSE
θ value	6.88961 (rank : 1284)	NC score	0.002553 (rank : 1524)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BND4	Gene names
Domain Architecture	No domain graphic available
Description	Protein DDX26B.

DYN3_HUMAN
θ value	6.88961 (rank : 1285)	NC score	0.010733 (rank : 1411)
Query Neighborhood Hits	1407	Target Neighborhood Hits	158	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

E2F1_MOUSE
θ value	6.88961 (rank : 1286)	NC score	-0.000574 (rank : 1567)
Query Neighborhood Hits	1407	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

ERCC5_MOUSE
θ value	6.88961 (rank : 1287)	NC score	0.007073 (rank : 1472)
Query Neighborhood Hits	1407	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

ETV4_HUMAN
θ value	6.88961 (rank : 1288)	NC score	0.001632 (rank : 1534)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

FLIP1_HUMAN
θ value	6.88961 (rank : 1289)	NC score	0.013014 (rank : 1390)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1405	Shared Neighborhood Hits	118
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FMNL_HUMAN
θ value	6.88961 (rank : 1290)	NC score	0.051869 (rank : 1108)
Query Neighborhood Hits	1407	Target Neighborhood Hits	529	Shared Neighborhood Hits	203
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

FOXQ1_HUMAN
θ value	6.88961 (rank : 1291)	NC score	-0.004791 (rank : 1598)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

FXR2_HUMAN
θ value	6.88961 (rank : 1292)	NC score	0.000426 (rank : 1556)
Query Neighborhood Hits	1407	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

GGN_HUMAN
θ value	6.88961 (rank : 1293)	NC score	0.071261 (rank : 955)
Query Neighborhood Hits	1407	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GR65_HUMAN
θ value	6.88961 (rank : 1294)	NC score	0.014377 (rank : 1377)
Query Neighborhood Hits	1407	Target Neighborhood Hits	148	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

GRIN1_HUMAN
θ value	6.88961 (rank : 1295)	NC score	0.052469 (rank : 1102)
Query Neighborhood Hits	1407	Target Neighborhood Hits	681	Shared Neighborhood Hits	213
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HCFC1_HUMAN
θ value	6.88961 (rank : 1296)	NC score	0.031878 (rank : 1223)
Query Neighborhood Hits	1407	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IRF3_HUMAN
θ value	6.88961 (rank : 1297)	NC score	0.003698 (rank : 1508)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

KC1A_HUMAN
θ value	6.88961 (rank : 1298)	NC score	0.640751 (rank : 776)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	666
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	6.88961 (rank : 1299)	NC score	0.640751 (rank : 777)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	666
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KLF5_MOUSE
θ value	6.88961 (rank : 1300)	NC score	-0.018867 (rank : 1646)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0Z7, Q9JMI2	Gene names	Klf5, Bteb2, Iklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2).

LAG3_HUMAN
θ value	6.88961 (rank : 1301)	NC score	0.004550 (rank : 1498)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	18
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LRP3_HUMAN
θ value	6.88961 (rank : 1302)	NC score	-0.003261 (rank : 1592)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	47
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

LTB1L_HUMAN
θ value	6.88961 (rank : 1303)	NC score	-0.007169 (rank : 1609)
Query Neighborhood Hits	1407	Target Neighborhood Hits	553	Shared Neighborhood Hits	68
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LV2H_HUMAN
θ value	6.88961 (rank : 1304)	NC score	-0.014119 (rank : 1630)
Query Neighborhood Hits	1407	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	P01711	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region VIL.

LYL1_HUMAN
θ value	6.88961 (rank : 1305)	NC score	-0.002116 (rank : 1586)
Query Neighborhood Hits	1407	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

MILK1_MOUSE
θ value	6.88961 (rank : 1306)	NC score	0.048489 (rank : 1134)
Query Neighborhood Hits	1407	Target Neighborhood Hits	788	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NPAS2_HUMAN
θ value	6.88961 (rank : 1307)	NC score	0.007259 (rank : 1469)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	45
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NUMBL_MOUSE
θ value	6.88961 (rank : 1308)	NC score	0.019517 (rank : 1327)
Query Neighborhood Hits	1407	Target Neighborhood Hits	147	Shared Neighborhood Hits	55
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

P73L_HUMAN
θ value	6.88961 (rank : 1309)	NC score	0.007442 (rank : 1466)
Query Neighborhood Hits	1407	Target Neighborhood Hits	102	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

PF21B_MOUSE
θ value	6.88961 (rank : 1310)	NC score	0.027797 (rank : 1259)
Query Neighborhood Hits	1407	Target Neighborhood Hits	278	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PHF22_HUMAN
θ value	6.88961 (rank : 1311)	NC score	0.007992 (rank : 1453)
Query Neighborhood Hits	1407	Target Neighborhood Hits	121	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

PKHA4_MOUSE
θ value	6.88961 (rank : 1312)	NC score	0.005876 (rank : 1481)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PTCD1_HUMAN
θ value	6.88961 (rank : 1313)	NC score	0.008192 (rank : 1450)
Query Neighborhood Hits	1407	Target Neighborhood Hits	52	Shared Neighborhood Hits	23
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

RFIP3_HUMAN
θ value	6.88961 (rank : 1314)	NC score	0.022736 (rank : 1298)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1055	Shared Neighborhood Hits	155
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RHG06_MOUSE
θ value	6.88961 (rank : 1315)	NC score	-0.000673 (rank : 1569)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RILP_HUMAN
θ value	6.88961 (rank : 1316)	NC score	0.008293 (rank : 1446)
Query Neighborhood Hits	1407	Target Neighborhood Hits	249	Shared Neighborhood Hits	36
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RIMB1_HUMAN
θ value	6.88961 (rank : 1317)	NC score	0.044986 (rank : 1143)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1479	Shared Neighborhood Hits	263
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIN3_HUMAN
θ value	6.88961 (rank : 1318)	NC score	0.035688 (rank : 1193)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RXRB_HUMAN
θ value	6.88961 (rank : 1319)	NC score	0.002594 (rank : 1523)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

SFPQ_MOUSE
θ value	6.88961 (rank : 1320)	NC score	0.067337 (rank : 986)
Query Neighborhood Hits	1407	Target Neighborhood Hits	958	Shared Neighborhood Hits	276
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SH23A_HUMAN
θ value	6.88961 (rank : 1321)	NC score	0.035896 (rank : 1191)
Query Neighborhood Hits	1407	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SIM2_HUMAN
θ value	6.88961 (rank : 1322)	NC score	-0.000749 (rank : 1571)
Query Neighborhood Hits	1407	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SMP1L_HUMAN
θ value	6.88961 (rank : 1323)	NC score	0.000459 (rank : 1555)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SYGP1_HUMAN
θ value	6.88961 (rank : 1324)	NC score	0.008228 (rank : 1448)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

SYNPO_HUMAN
θ value	6.88961 (rank : 1325)	NC score	0.037053 (rank : 1184)
Query Neighborhood Hits	1407	Target Neighborhood Hits	281	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TARA_HUMAN
θ value	6.88961 (rank : 1326)	NC score	0.052005 (rank : 1107)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1626	Shared Neighborhood Hits	311
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TBX21_HUMAN
θ value	6.88961 (rank : 1327)	NC score	0.001610 (rank : 1535)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

TBX4_HUMAN
θ value	6.88961 (rank : 1328)	NC score	-0.000690 (rank : 1570)
Query Neighborhood Hits	1407	Target Neighborhood Hits	70	Shared Neighborhood Hits	16
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

TITIN_HUMAN
θ value	6.88961 (rank : 1329)	NC score	0.656492 (rank : 767)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2923	Shared Neighborhood Hits	955
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TREF1_HUMAN
θ value	6.88961 (rank : 1330)	NC score	0.002994 (rank : 1516)
Query Neighborhood Hits	1407	Target Neighborhood Hits	651	Shared Neighborhood Hits	89
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

TRPC6_MOUSE
θ value	6.88961 (rank : 1331)	NC score	-0.002149 (rank : 1587)
Query Neighborhood Hits	1407	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TULP1_HUMAN
θ value	6.88961 (rank : 1332)	NC score	0.008777 (rank : 1437)
Query Neighborhood Hits	1407	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	O00294, O43536	Gene names	TULP1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

UBP30_HUMAN
θ value	6.88961 (rank : 1333)	NC score	-0.001099 (rank : 1574)
Query Neighborhood Hits	1407	Target Neighborhood Hits	94	Shared Neighborhood Hits	14
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

US6NL_HUMAN
θ value	6.88961 (rank : 1334)	NC score	0.007947 (rank : 1456)
Query Neighborhood Hits	1407	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

XPC_HUMAN
θ value	6.88961 (rank : 1335)	NC score	0.007499 (rank : 1465)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q01831, Q96AX0	Gene names	XPC, XPCC
Domain Architecture
Description	DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125).

ZN509_MOUSE
θ value	6.88961 (rank : 1336)	NC score	-0.021068 (rank : 1653)
Query Neighborhood Hits	1407	Target Neighborhood Hits	990	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ANR40_MOUSE
θ value	8.99809 (rank : 1337)	NC score	0.012372 (rank : 1396)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ARI1A_HUMAN
θ value	8.99809 (rank : 1338)	NC score	0.056421 (rank : 1062)
Query Neighborhood Hits	1407	Target Neighborhood Hits	787	Shared Neighborhood Hits	239
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

B4GT1_HUMAN
θ value	8.99809 (rank : 1339)	NC score	0.003426 (rank : 1511)
Query Neighborhood Hits	1407	Target Neighborhood Hits	168	Shared Neighborhood Hits	45
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

BAT2_HUMAN
θ value	8.99809 (rank : 1340)	NC score	0.080265 (rank : 930)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	352
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT3_HUMAN
θ value	8.99809 (rank : 1341)	NC score	0.036423 (rank : 1188)
Query Neighborhood Hits	1407	Target Neighborhood Hits	490	Shared Neighborhood Hits	163
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAT3_MOUSE
θ value	8.99809 (rank : 1342)	NC score	0.041861 (rank : 1160)
Query Neighborhood Hits	1407	Target Neighborhood Hits	518	Shared Neighborhood Hits	185
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CD5R2_HUMAN
θ value	8.99809 (rank : 1343)	NC score	0.007705 (rank : 1462)
Query Neighborhood Hits	1407	Target Neighborhood Hits	53	Shared Neighborhood Hits	30
SwissProt Accessions	Q13319, Q4ZFW6	Gene names	CDK5R2, NCK5AI
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

CD5R2_MOUSE
θ value	8.99809 (rank : 1344)	NC score	0.012092 (rank : 1402)
Query Neighborhood Hits	1407	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	O35926, O35277	Gene names	Cdk5r2, Nck5ai
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

CDX1_MOUSE
θ value	8.99809 (rank : 1345)	NC score	-0.007371 (rank : 1610)
Query Neighborhood Hits	1407	Target Neighborhood Hits	379	Shared Neighborhood Hits	60
SwissProt Accessions	P18111, Q8VCF7	Gene names	Cdx1, Cdx-1
Domain Architecture
Description	Homeobox protein CDX-1 (Caudal-type homeobox protein 1).

CECR6_HUMAN
θ value	8.99809 (rank : 1346)	NC score	0.002848 (rank : 1518)
Query Neighborhood Hits	1407	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BXQ6	Gene names	CECR6
Domain Architecture	No domain graphic available
Description	Cat eye syndrome critical region protein 6.

CENG1_HUMAN
θ value	8.99809 (rank : 1347)	NC score	0.008214 (rank : 1449)
Query Neighborhood Hits	1407	Target Neighborhood Hits	544	Shared Neighborhood Hits	91
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CM003_MOUSE
θ value	8.99809 (rank : 1348)	NC score	0.002344 (rank : 1527)
Query Neighborhood Hits	1407	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C263	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf3 homolog.

CO4A1_MOUSE
θ value	8.99809 (rank : 1349)	NC score	0.015362 (rank : 1362)
Query Neighborhood Hits	1407	Target Neighborhood Hits	450	Shared Neighborhood Hits	132
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CSF1_HUMAN
θ value	8.99809 (rank : 1350)	NC score	0.029633 (rank : 1244)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	94
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

DAZP2_HUMAN
θ value	8.99809 (rank : 1351)	NC score	0.008162 (rank : 1451)
Query Neighborhood Hits	1407	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q15038	Gene names	DAZAP2, KIAA0058
Domain Architecture	No domain graphic available
Description	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2).

DEMA_HUMAN
θ value	8.99809 (rank : 1352)	NC score	0.001564 (rank : 1537)
Query Neighborhood Hits	1407	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q08495, Q13215, Q9BRE3	Gene names	EPB49, DMT
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

DIAP1_HUMAN
θ value	8.99809 (rank : 1353)	NC score	0.033545 (rank : 1209)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	188
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

DNM3A_HUMAN
θ value	8.99809 (rank : 1354)	NC score	0.006618 (rank : 1475)
Query Neighborhood Hits	1407	Target Neighborhood Hits	104	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

ETV4_MOUSE
θ value	8.99809 (rank : 1355)	NC score	0.001563 (rank : 1538)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

FMN2_HUMAN
θ value	8.99809 (rank : 1356)	NC score	0.062098 (rank : 1017)
Query Neighborhood Hits	1407	Target Neighborhood Hits	484	Shared Neighborhood Hits	201
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FMNL_MOUSE
θ value	8.99809 (rank : 1357)	NC score	0.035236 (rank : 1197)
Query Neighborhood Hits	1407	Target Neighborhood Hits	428	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

FOXK2_HUMAN
θ value	8.99809 (rank : 1358)	NC score	-0.001767 (rank : 1581)
Query Neighborhood Hits	1407	Target Neighborhood Hits	190	Shared Neighborhood Hits	47
SwissProt Accessions	Q01167, Q13622, Q13623, Q13624	Gene names	FOXK2, ILF, ILF1
Domain Architecture
Description	Forkhead box protein K2 (Interleukin enhancer-binding factor 1) (Cellular transcription factor ILF-1).

FOXN1_HUMAN
θ value	8.99809 (rank : 1359)	NC score	0.002808 (rank : 1520)
Query Neighborhood Hits	1407	Target Neighborhood Hits	377	Shared Neighborhood Hits	116
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

FOXO4_HUMAN
θ value	8.99809 (rank : 1360)	NC score	-0.003808 (rank : 1595)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

FYB_HUMAN
θ value	8.99809 (rank : 1361)	NC score	0.036722 (rank : 1187)
Query Neighborhood Hits	1407	Target Neighborhood Hits	379	Shared Neighborhood Hits	124
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GAB1_HUMAN
θ value	8.99809 (rank : 1362)	NC score	0.013943 (rank : 1380)
Query Neighborhood Hits	1407	Target Neighborhood Hits	279	Shared Neighborhood Hits	84
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GMEB2_MOUSE
θ value	8.99809 (rank : 1363)	NC score	0.001503 (rank : 1540)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	P58929, Q6PCY0	Gene names	Gmeb2
Domain Architecture	No domain graphic available
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2).

GRIP1_HUMAN
θ value	8.99809 (rank : 1364)	NC score	0.005106 (rank : 1491)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GT2D1_HUMAN
θ value	8.99809 (rank : 1365)	NC score	0.001015 (rank : 1546)
Query Neighborhood Hits	1407	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHL9, O95444, Q75MX7, Q86UM3, Q8WVC4, Q9UHK8, Q9UI91	Gene names	GTF2IRD1, CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, WBSCR12
Domain Architecture
Description	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (Muscle TFII-I repeat domain-containing protein 1) (General transcription factor III) (Slow- muscle-fiber enhancer-binding protein) (USE B1-binding protein) (MusTRD1/BEN) (Williams-Beuren syndrome chromosome region 11 protein).

HME1_MOUSE
θ value	8.99809 (rank : 1366)	NC score	-0.008700 (rank : 1615)
Query Neighborhood Hits	1407	Target Neighborhood Hits	397	Shared Neighborhood Hits	50
SwissProt Accessions	P09065	Gene names	En1, En-1
Domain Architecture
Description	Homeobox protein engrailed-1 (Mo-En-1).

IASPP_HUMAN
θ value	8.99809 (rank : 1367)	NC score	0.069875 (rank : 964)
Query Neighborhood Hits	1407	Target Neighborhood Hits	688	Shared Neighborhood Hits	214
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IKAR_MOUSE
θ value	8.99809 (rank : 1368)	NC score	-0.021212 (rank : 1654)
Query Neighborhood Hits	1407	Target Neighborhood Hits	734	Shared Neighborhood Hits	47
SwissProt Accessions	Q03267, Q64044, Q64045, Q64051	Gene names	Ikzf1, Ikaros, Lyf1, Zfpn1a1, Znfn1a1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

IRS2_HUMAN
θ value	8.99809 (rank : 1369)	NC score	0.038549 (rank : 1175)
Query Neighborhood Hits	1407	Target Neighborhood Hits	262	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

JADE2_MOUSE
θ value	8.99809 (rank : 1370)	NC score	0.023284 (rank : 1295)
Query Neighborhood Hits	1407	Target Neighborhood Hits	560	Shared Neighborhood Hits	177
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

K0423_MOUSE
θ value	8.99809 (rank : 1371)	NC score	0.002934 (rank : 1517)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

KBTB9_HUMAN
θ value	8.99809 (rank : 1372)	NC score	-0.010854 (rank : 1620)
Query Neighborhood Hits	1407	Target Neighborhood Hits	192	Shared Neighborhood Hits	12
SwissProt Accessions	Q96CT2, Q8N388, Q96BF0, Q96PW7	Gene names	KBTBD9, KIAA1921
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 9.

KCD12_MOUSE
θ value	8.99809 (rank : 1373)	NC score	-0.003399 (rank : 1593)
Query Neighborhood Hits	1407	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q6WVG3	Gene names	Kctd12, Pfet1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain).

KLF13_HUMAN
θ value	8.99809 (rank : 1374)	NC score	-0.018580 (rank : 1644)
Query Neighborhood Hits	1407	Target Neighborhood Hits	739	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y2Y9, Q9Y356	Gene names	KLF13, BTEB3, NSLP1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor NSLP1) (Novel Sp1-like zinc finger transcription factor 1).

LRFN4_HUMAN
θ value	8.99809 (rank : 1375)	NC score	0.008582 (rank : 1439)
Query Neighborhood Hits	1407	Target Neighborhood Hits	462	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LSD1_HUMAN
θ value	8.99809 (rank : 1376)	NC score	0.014951 (rank : 1368)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	107
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

MYCL1_HUMAN
θ value	8.99809 (rank : 1377)	NC score	-0.000018 (rank : 1561)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYOD1_HUMAN
θ value	8.99809 (rank : 1378)	NC score	-0.000772 (rank : 1572)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	15
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

NFAC1_HUMAN
θ value	8.99809 (rank : 1379)	NC score	0.018359 (rank : 1336)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	126
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NGEF_MOUSE
θ value	8.99809 (rank : 1380)	NC score	0.004005 (rank : 1501)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NONO_HUMAN
θ value	8.99809 (rank : 1381)	NC score	0.009250 (rank : 1430)
Query Neighborhood Hits	1407	Target Neighborhood Hits	441	Shared Neighborhood Hits	42
SwissProt Accessions	Q15233, O00201, P30807, Q12786, Q9BQC5	Gene names	NONO, NRB54
Domain Architecture
Description	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit).

OAS3_HUMAN
θ value	8.99809 (rank : 1382)	NC score	0.000841 (rank : 1548)
Query Neighborhood Hits	1407	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

ODO2_HUMAN
θ value	8.99809 (rank : 1383)	NC score	0.010453 (rank : 1418)
Query Neighborhood Hits	1407	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

PALB2_HUMAN
θ value	8.99809 (rank : 1384)	NC score	0.006007 (rank : 1479)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	25
SwissProt Accessions	Q86YC2, Q8N7Y6, Q8ND31, Q9H6W1	Gene names	PALB2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

PALB2_MOUSE
θ value	8.99809 (rank : 1385)	NC score	0.014669 (rank : 1372)
Query Neighborhood Hits	1407	Target Neighborhood Hits	133	Shared Neighborhood Hits	44
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

PARC_MOUSE
θ value	8.99809 (rank : 1386)	NC score	-0.003179 (rank : 1591)
Query Neighborhood Hits	1407	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PCD15_MOUSE
θ value	8.99809 (rank : 1387)	NC score	-0.004047 (rank : 1596)
Query Neighborhood Hits	1407	Target Neighborhood Hits	262	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

PCDGI_HUMAN
θ value	8.99809 (rank : 1388)	NC score	-0.009712 (rank : 1618)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y5F9, Q9Y5C5	Gene names	PCDHGB6
Domain Architecture
Description	Protocadherin gamma B6 precursor (PCDH-gamma-B6).

PHLPL_HUMAN
θ value	8.99809 (rank : 1389)	NC score	-0.001492 (rank : 1579)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PLCB2_HUMAN
θ value	8.99809 (rank : 1390)	NC score	0.010571 (rank : 1413)
Query Neighborhood Hits	1407	Target Neighborhood Hits	608	Shared Neighborhood Hits	58
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLS1_HUMAN
θ value	8.99809 (rank : 1391)	NC score	0.000798 (rank : 1551)
Query Neighborhood Hits	1407	Target Neighborhood Hits	35	Shared Neighborhood Hits	13
SwissProt Accessions	O15162	Gene names	PLSCR1
Domain Architecture
Description	Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (MmTRA1b).

RBCC1_HUMAN
θ value	8.99809 (rank : 1392)	NC score	0.022037 (rank : 1305)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

SDK2_MOUSE
θ value	8.99809 (rank : 1393)	NC score	0.042335 (rank : 1156)
Query Neighborhood Hits	1407	Target Neighborhood Hits	480	Shared Neighborhood Hits	88
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SELPL_MOUSE
θ value	8.99809 (rank : 1394)	NC score	0.057097 (rank : 1054)
Query Neighborhood Hits	1407	Target Neighborhood Hits	588	Shared Neighborhood Hits	194
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SNRPA_MOUSE
θ value	8.99809 (rank : 1395)	NC score	0.004846 (rank : 1493)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	25
SwissProt Accessions	Q62189, Q52LA2	Gene names	Snrpa, Rnu1a-1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1A protein) (U1-A).

SRBP1_HUMAN
θ value	8.99809 (rank : 1396)	NC score	0.036866 (rank : 1185)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	93
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TGON2_HUMAN
θ value	8.99809 (rank : 1397)	NC score	0.050204 (rank : 1126)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	223
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TGON2_MOUSE
θ value	8.99809 (rank : 1398)	NC score	0.027575 (rank : 1264)
Query Neighborhood Hits	1407	Target Neighborhood Hits	277	Shared Neighborhood Hits	62
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

TIF1G_MOUSE
θ value	8.99809 (rank : 1399)	NC score	0.015511 (rank : 1361)
Query Neighborhood Hits	1407	Target Neighborhood Hits	498	Shared Neighborhood Hits	120
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TROAP_HUMAN
θ value	8.99809 (rank : 1400)	NC score	0.034993 (rank : 1198)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	104
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

TRYA1_HUMAN
θ value	8.99809 (rank : 1401)	NC score	-0.013268 (rank : 1626)
Query Neighborhood Hits	1407	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

TRYD_HUMAN
θ value	8.99809 (rank : 1402)	NC score	-0.012962 (rank : 1625)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

USH1C_MOUSE
θ value	8.99809 (rank : 1403)	NC score	0.016883 (rank : 1351)
Query Neighborhood Hits	1407	Target Neighborhood Hits	557	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

XYLT2_MOUSE
θ value	8.99809 (rank : 1404)	NC score	0.002749 (rank : 1521)
Query Neighborhood Hits	1407	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPL0, Q5SUY1, Q8K060	Gene names	Xylt2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (Peptide O- xylosyltransferase 2).

ZEP2_MOUSE
θ value	8.99809 (rank : 1405)	NC score	-0.009441 (rank : 1617)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	136
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZN750_HUMAN
θ value	8.99809 (rank : 1406)	NC score	0.015096 (rank : 1367)
Query Neighborhood Hits	1407	Target Neighborhood Hits	183	Shared Neighborhood Hits	60
SwissProt Accessions	Q32MQ0, Q9H899	Gene names	ZNF750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

ZYX_MOUSE
θ value	8.99809 (rank : 1407)	NC score	0.031478 (rank : 1229)
Query Neighborhood Hits	1407	Target Neighborhood Hits	347	Shared Neighborhood Hits	111
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ALEX_HUMAN
θ value	θ > 10 (rank : 1408)	NC score	0.065679 (rank : 997)
Query Neighborhood Hits	1407	Target Neighborhood Hits	361	Shared Neighborhood Hits	177
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALEX_MOUSE
θ value	θ > 10 (rank : 1409)	NC score	0.056979 (rank : 1056)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	105
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ALK_HUMAN
θ value	θ > 10 (rank : 1410)	NC score	0.679878 (rank : 752)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	683
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 1411)	NC score	0.677794 (rank : 755)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	695
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

APS_HUMAN
θ value	θ > 10 (rank : 1412)	NC score	0.061581 (rank : 1021)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	66
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ASPP1_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.056072 (rank : 1065)
Query Neighborhood Hits	1407	Target Neighborhood Hits	956	Shared Neighborhood Hits	187
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 1414)	NC score	0.052580 (rank : 1100)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1156	Shared Neighborhood Hits	217
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BASP_HUMAN
θ value	θ > 10 (rank : 1415)	NC score	0.064062 (rank : 1007)
Query Neighborhood Hits	1407	Target Neighborhood Hits	321	Shared Neighborhood Hits	111
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BASP_MOUSE
θ value	θ > 10 (rank : 1416)	NC score	0.064281 (rank : 1003)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	94
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BAT2_MOUSE
θ value	θ > 10 (rank : 1417)	NC score	0.060178 (rank : 1030)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	336
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BRD4_MOUSE
θ value	θ > 10 (rank : 1418)	NC score	0.061049 (rank : 1026)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	277
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.084777 (rank : 919)
Query Neighborhood Hits	1407	Target Neighborhood Hits	208	Shared Neighborhood Hits	108
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.068446 (rank : 973)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

BUB1_HUMAN
θ value	θ > 10 (rank : 1421)	NC score	0.362124 (rank : 838)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	388
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CDC7_HUMAN
θ value	θ > 10 (rank : 1422)	NC score	0.634072 (rank : 789)
Query Neighborhood Hits	1407	Target Neighborhood Hits	652	Shared Neighborhood Hits	584
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDN1C_HUMAN
θ value	θ > 10 (rank : 1423)	NC score	0.053760 (rank : 1090)
Query Neighborhood Hits	1407	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CHIN_HUMAN
θ value	θ > 10 (rank : 1424)	NC score	0.077542 (rank : 935)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	69
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1425)	NC score	0.078503 (rank : 931)
Query Neighborhood Hits	1407	Target Neighborhood Hits	229	Shared Neighborhood Hits	70
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1426)	NC score	0.078497 (rank : 932)
Query Neighborhood Hits	1407	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1427)	NC score	0.066499 (rank : 990)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CJ078_MOUSE
θ value	θ > 10 (rank : 1428)	NC score	0.069055 (rank : 972)
Query Neighborhood Hits	1407	Target Neighborhood Hits	559	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CK024_HUMAN
θ value	θ > 10 (rank : 1429)	NC score	0.069393 (rank : 970)
Query Neighborhood Hits	1407	Target Neighborhood Hits	408	Shared Neighborhood Hits	169
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CLK1_HUMAN
θ value	θ > 10 (rank : 1430)	NC score	0.716022 (rank : 697)
Query Neighborhood Hits	1407	Target Neighborhood Hits	756	Shared Neighborhood Hits	671
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
θ value	θ > 10 (rank : 1431)	NC score	0.718443 (rank : 686)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	677
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	θ > 10 (rank : 1432)	NC score	0.703149 (rank : 718)
Query Neighborhood Hits	1407	Target Neighborhood Hits	752	Shared Neighborhood Hits	664
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK2_MOUSE
θ value	θ > 10 (rank : 1433)	NC score	0.689228 (rank : 739)
Query Neighborhood Hits	1407	Target Neighborhood Hits	743	Shared Neighborhood Hits	660
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CLK3_HUMAN
θ value	θ > 10 (rank : 1434)	NC score	0.687216 (rank : 743)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	662
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	θ > 10 (rank : 1435)	NC score	0.686558 (rank : 744)
Query Neighborhood Hits	1407	Target Neighborhood Hits	761	Shared Neighborhood Hits	662
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK4_HUMAN
θ value	θ > 10 (rank : 1436)	NC score	0.712458 (rank : 703)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	681
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	θ > 10 (rank : 1437)	NC score	0.711130 (rank : 708)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	679
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CNOT3_HUMAN
θ value	θ > 10 (rank : 1438)	NC score	0.051509 (rank : 1111)
Query Neighborhood Hits	1407	Target Neighborhood Hits	425	Shared Neighborhood Hits	133
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNOT3_MOUSE
θ value	θ > 10 (rank : 1439)	NC score	0.051328 (rank : 1112)
Query Neighborhood Hits	1407	Target Neighborhood Hits	504	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CPSF6_HUMAN
θ value	θ > 10 (rank : 1440)	NC score	0.053992 (rank : 1088)
Query Neighborhood Hits	1407	Target Neighborhood Hits	359	Shared Neighborhood Hits	165
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	θ > 10 (rank : 1441)	NC score	0.054883 (rank : 1075)
Query Neighborhood Hits	1407	Target Neighborhood Hits	356	Shared Neighborhood Hits	166
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CRKL_HUMAN
θ value	θ > 10 (rank : 1442)	NC score	0.073818 (rank : 948)
Query Neighborhood Hits	1407	Target Neighborhood Hits	313	Shared Neighborhood Hits	73
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1443)	NC score	0.074329 (rank : 947)
Query Neighborhood Hits	1407	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1444)	NC score	0.063850 (rank : 1009)
Query Neighborhood Hits	1407	Target Neighborhood Hits	308	Shared Neighborhood Hits	70
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1445)	NC score	0.062416 (rank : 1016)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	73
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSF1R_HUMAN
θ value	θ > 10 (rank : 1446)	NC score	0.611338 (rank : 801)
Query Neighborhood Hits	1407	Target Neighborhood Hits	943	Shared Neighborhood Hits	726
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 1447)	NC score	0.606855 (rank : 806)
Query Neighborhood Hits	1407	Target Neighborhood Hits	983	Shared Neighborhood Hits	729
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSKI2_HUMAN
θ value	θ > 10 (rank : 1448)	NC score	0.065777 (rank : 995)
Query Neighborhood Hits	1407	Target Neighborhood Hits	747	Shared Neighborhood Hits	238
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	θ > 10 (rank : 1449)	NC score	0.061760 (rank : 1019)
Query Neighborhood Hits	1407	Target Neighborhood Hits	812	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DAPP1_HUMAN
θ value	θ > 10 (rank : 1450)	NC score	0.077616 (rank : 934)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1451)	NC score	0.075358 (rank : 945)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCX_HUMAN
θ value	θ > 10 (rank : 1452)	NC score	0.059003 (rank : 1038)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	54
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1453)	NC score	0.054652 (rank : 1079)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	42
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DDR2_HUMAN
θ value	θ > 10 (rank : 1454)	NC score	0.699506 (rank : 728)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DGKD_HUMAN
θ value	θ > 10 (rank : 1455)	NC score	0.076074 (rank : 938)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	77
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1456)	NC score	0.069990 (rank : 963)
Query Neighborhood Hits	1407	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	θ > 10 (rank : 1457)	NC score	0.068123 (rank : 978)
Query Neighborhood Hits	1407	Target Neighborhood Hits	378	Shared Neighborhood Hits	175
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1458)	NC score	0.062532 (rank : 1015)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DYRK2_HUMAN
θ value	θ > 10 (rank : 1459)	NC score	0.769299 (rank : 575)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	707
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DYRK3_HUMAN
θ value	θ > 10 (rank : 1460)	NC score	0.764306 (rank : 594)
Query Neighborhood Hits	1407	Target Neighborhood Hits	798	Shared Neighborhood Hits	710
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

DYRK4_HUMAN
θ value	θ > 10 (rank : 1461)	NC score	0.742133 (rank : 645)
Query Neighborhood Hits	1407	Target Neighborhood Hits	750	Shared Neighborhood Hits	675
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

EFS_HUMAN
θ value	θ > 10 (rank : 1462)	NC score	0.050240 (rank : 1125)
Query Neighborhood Hits	1407	Target Neighborhood Hits	348	Shared Neighborhood Hits	137
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ERBB3_HUMAN
θ value	θ > 10 (rank : 1463)	NC score	0.703099 (rank : 719)
Query Neighborhood Hits	1407	Target Neighborhood Hits	918	Shared Neighborhood Hits	727
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ES8L3_HUMAN
θ value	θ > 10 (rank : 1464)	NC score	0.054612 (rank : 1081)
Query Neighborhood Hits	1407	Target Neighborhood Hits	206	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FLT3_HUMAN
θ value	θ > 10 (rank : 1465)	NC score	0.637143 (rank : 785)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	723
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 1466)	NC score	0.632767 (rank : 792)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	727
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GGN_MOUSE
θ value	θ > 10 (rank : 1467)	NC score	0.077982 (rank : 933)
Query Neighborhood Hits	1407	Target Neighborhood Hits	311	Shared Neighborhood Hits	173
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRAP2_HUMAN
θ value	θ > 10 (rank : 1468)	NC score	0.111428 (rank : 863)
Query Neighborhood Hits	1407	Target Neighborhood Hits	304	Shared Neighborhood Hits	73
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1469)	NC score	0.109403 (rank : 864)
Query Neighborhood Hits	1407	Target Neighborhood Hits	297	Shared Neighborhood Hits	69
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1470)	NC score	0.113391 (rank : 860)
Query Neighborhood Hits	1407	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1471)	NC score	0.112799 (rank : 862)
Query Neighborhood Hits	1407	Target Neighborhood Hits	309	Shared Neighborhood Hits	74
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB14_HUMAN
θ value	θ > 10 (rank : 1472)	NC score	0.060170 (rank : 1031)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1473)	NC score	0.065684 (rank : 996)
Query Neighborhood Hits	1407	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1474)	NC score	0.109194 (rank : 865)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1475)	NC score	0.109160 (rank : 866)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	71
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_HUMAN
θ value	θ > 10 (rank : 1476)	NC score	0.052218 (rank : 1105)
Query Neighborhood Hits	1407	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 1477)	NC score	0.056387 (rank : 1063)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRK4_MOUSE
θ value	θ > 10 (rank : 1478)	NC score	0.802241 (rank : 517)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	727
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 1479)	NC score	0.808689 (rank : 505)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	732
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 1480)	NC score	0.809155 (rank : 502)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	732
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 1481)	NC score	0.812634 (rank : 493)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	737
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 1482)	NC score	0.812420 (rank : 495)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	738
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRP3_HUMAN
θ value	θ > 10 (rank : 1483)	NC score	0.093394 (rank : 892)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2C_HUMAN
θ value	θ > 10 (rank : 1484)	NC score	0.557410 (rank : 814)
Query Neighborhood Hits	1407	Target Neighborhood Hits	624	Shared Neighborhood Hits	543
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 1485)	NC score	0.547872 (rank : 815)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	627
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 1486)	NC score	0.531322 (rank : 824)
Query Neighborhood Hits	1407	Target Neighborhood Hits	692	Shared Neighborhood Hits	605
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

HSH2D_HUMAN
θ value	θ > 10 (rank : 1487)	NC score	0.071173 (rank : 956)
Query Neighborhood Hits	1407	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_MOUSE
θ value	θ > 10 (rank : 1488)	NC score	0.068047 (rank : 981)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1024	Shared Neighborhood Hits	286
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

INVO_MOUSE
θ value	θ > 10 (rank : 1489)	NC score	0.055376 (rank : 1069)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	94
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK2_HUMAN
θ value	θ > 10 (rank : 1490)	NC score	0.700381 (rank : 726)
Query Neighborhood Hits	1407	Target Neighborhood Hits	714	Shared Neighborhood Hits	650
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ITSN1_MOUSE
θ value	θ > 10 (rank : 1491)	NC score	0.057165 (rank : 1052)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1669	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 1492)	NC score	0.054688 (rank : 1077)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1173	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 1493)	NC score	0.050887 (rank : 1116)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1371	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JAK3_MOUSE
θ value	θ > 10 (rank : 1494)	NC score	0.787084 (rank : 538)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	738
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K2002_HUMAN
θ value	θ > 10 (rank : 1495)	NC score	0.281119 (rank : 845)
Query Neighborhood Hits	1407	Target Neighborhood Hits	274	Shared Neighborhood Hits	237
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 1496)	NC score	0.231508 (rank : 847)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	210
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KC1D_HUMAN
θ value	θ > 10 (rank : 1497)	NC score	0.637565 (rank : 783)
Query Neighborhood Hits	1407	Target Neighborhood Hits	737	Shared Neighborhood Hits	663
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 1498)	NC score	0.637580 (rank : 782)
Query Neighborhood Hits	1407	Target Neighborhood Hits	737	Shared Neighborhood Hits	663
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 1499)	NC score	0.633166 (rank : 790)
Query Neighborhood Hits	1407	Target Neighborhood Hits	732	Shared Neighborhood Hits	663
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 1500)	NC score	0.633136 (rank : 791)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	662
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G1_HUMAN
θ value	θ > 10 (rank : 1501)	NC score	0.607760 (rank : 805)
Query Neighborhood Hits	1407	Target Neighborhood Hits	708	Shared Neighborhood Hits	638
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	θ > 10 (rank : 1502)	NC score	0.609031 (rank : 803)
Query Neighborhood Hits	1407	Target Neighborhood Hits	713	Shared Neighborhood Hits	640
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G2_HUMAN
θ value	θ > 10 (rank : 1503)	NC score	0.580503 (rank : 811)
Query Neighborhood Hits	1407	Target Neighborhood Hits	693	Shared Neighborhood Hits	627
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	θ > 10 (rank : 1504)	NC score	0.582303 (rank : 810)
Query Neighborhood Hits	1407	Target Neighborhood Hits	695	Shared Neighborhood Hits	628
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	θ > 10 (rank : 1505)	NC score	0.603352 (rank : 808)
Query Neighborhood Hits	1407	Target Neighborhood Hits	711	Shared Neighborhood Hits	639
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KS6C1_HUMAN
θ value	θ > 10 (rank : 1506)	NC score	0.623445 (rank : 799)
Query Neighborhood Hits	1407	Target Neighborhood Hits	682	Shared Neighborhood Hits	597
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 1507)	NC score	0.629674 (rank : 796)
Query Neighborhood Hits	1407	Target Neighborhood Hits	700	Shared Neighborhood Hits	600
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LCP2_HUMAN
θ value	θ > 10 (rank : 1508)	NC score	0.067600 (rank : 985)
Query Neighborhood Hits	1407	Target Neighborhood Hits	531	Shared Neighborhood Hits	193
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 1509)	NC score	0.056057 (rank : 1066)
Query Neighborhood Hits	1407	Target Neighborhood Hits	151	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MAPK5_HUMAN
θ value	θ > 10 (rank : 1510)	NC score	0.806099 (rank : 513)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	715
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 1511)	NC score	0.807122 (rank : 508)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARCS_HUMAN
θ value	θ > 10 (rank : 1512)	NC score	0.057080 (rank : 1055)
Query Neighborhood Hits	1407	Target Neighborhood Hits	204	Shared Neighborhood Hits	85
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

MARCS_MOUSE
θ value	θ > 10 (rank : 1513)	NC score	0.052382 (rank : 1104)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	89
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

MAVS_HUMAN
θ value	θ > 10 (rank : 1514)	NC score	0.052214 (rank : 1106)
Query Neighborhood Hits	1407	Target Neighborhood Hits	271	Shared Neighborhood Hits	117
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MBD6_HUMAN
θ value	θ > 10 (rank : 1515)	NC score	0.086346 (rank : 914)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	180
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MELK_HUMAN
θ value	θ > 10 (rank : 1516)	NC score	0.858209 (rank : 275)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	749
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MET_HUMAN
θ value	θ > 10 (rank : 1517)	NC score	0.719088 (rank : 684)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	734
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 1518)	NC score	0.721460 (rank : 682)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	737
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MK01_HUMAN
θ value	θ > 10 (rank : 1519)	NC score	0.816111 (rank : 484)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 1520)	NC score	0.816024 (rank : 485)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MUC1_MOUSE
θ value	θ > 10 (rank : 1521)	NC score	0.068063 (rank : 980)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	113
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUSK_HUMAN
θ value	θ > 10 (rank : 1522)	NC score	0.645225 (rank : 772)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1074	Shared Neighborhood Hits	722
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 1523)	NC score	0.641367 (rank : 775)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1057	Shared Neighborhood Hits	722
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

NCK1_HUMAN
θ value	θ > 10 (rank : 1524)	NC score	0.106013 (rank : 870)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	71
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1525)	NC score	0.106842 (rank : 869)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	73
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOR2_HUMAN
θ value	θ > 10 (rank : 1526)	NC score	0.057342 (rank : 1050)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	255
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NEO1_HUMAN
θ value	θ > 10 (rank : 1527)	NC score	0.053476 (rank : 1093)
Query Neighborhood Hits	1407	Target Neighborhood Hits	530	Shared Neighborhood Hits	95
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1528)	NC score	0.054217 (rank : 1086)
Query Neighborhood Hits	1407	Target Neighborhood Hits	523	Shared Neighborhood Hits	103
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NPHP1_HUMAN
θ value	θ > 10 (rank : 1529)	NC score	0.055507 (rank : 1067)
Query Neighborhood Hits	1407	Target Neighborhood Hits	288	Shared Neighborhood Hits	60
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1530)	NC score	0.057824 (rank : 1047)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRBP2_HUMAN
θ value	θ > 10 (rank : 1531)	NC score	0.064453 (rank : 1002)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSY0, Q597G7, Q8NCX8, Q8WYS5	Gene names	NRBP2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein 2 (Transformation-related protein 16).

NRBP2_MOUSE
θ value	θ > 10 (rank : 1532)	NC score	0.066178 (rank : 994)
Query Neighborhood Hits	1407	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q91V36, Q8R3M0	Gene names	Nrbp2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein 2.

OSTF1_HUMAN
θ value	θ > 10 (rank : 1533)	NC score	0.058819 (rank : 1041)
Query Neighborhood Hits	1407	Target Neighborhood Hits	466	Shared Neighborhood Hits	77
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 1534)	NC score	0.054646 (rank : 1080)
Query Neighborhood Hits	1407	Target Neighborhood Hits	467	Shared Neighborhood Hits	77
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 1535)	NC score	0.064568 (rank : 1001)
Query Neighborhood Hits	1407	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1536)	NC score	0.066232 (rank : 993)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	71
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1537)	NC score	0.055141 (rank : 1073)
Query Neighborhood Hits	1407	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1538)	NC score	0.054418 (rank : 1083)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	78
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1539)	NC score	0.067332 (rank : 987)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	108
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1540)	NC score	0.067927 (rank : 982)
Query Neighborhood Hits	1407	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PDZD8_HUMAN
θ value	θ > 10 (rank : 1541)	NC score	0.075416 (rank : 941)
Query Neighborhood Hits	1407	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PGFRA_HUMAN
θ value	θ > 10 (rank : 1542)	NC score	0.643574 (rank : 773)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	729
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 1543)	NC score	0.642813 (rank : 774)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	727
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 1544)	NC score	0.637991 (rank : 781)
Query Neighborhood Hits	1407	Target Neighborhood Hits	962	Shared Neighborhood Hits	731
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 1545)	NC score	0.636907 (rank : 786)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	732
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PI3R4_MOUSE
θ value	θ > 10 (rank : 1546)	NC score	0.340238 (rank : 840)
Query Neighborhood Hits	1407	Target Neighborhood Hits	535	Shared Neighborhood Hits	351
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PINK1_HUMAN
θ value	θ > 10 (rank : 1547)	NC score	0.716158 (rank : 696)
Query Neighborhood Hits	1407	Target Neighborhood Hits	741	Shared Neighborhood Hits	664
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PLCG1_HUMAN
θ value	θ > 10 (rank : 1548)	NC score	0.069129 (rank : 971)
Query Neighborhood Hits	1407	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1549)	NC score	0.069769 (rank : 965)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1550)	NC score	0.068193 (rank : 977)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	63
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PO121_HUMAN
θ value	θ > 10 (rank : 1551)	NC score	0.063022 (rank : 1012)
Query Neighborhood Hits	1407	Target Neighborhood Hits	344	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

PO121_MOUSE
θ value	θ > 10 (rank : 1552)	NC score	0.058855 (rank : 1039)
Query Neighborhood Hits	1407	Target Neighborhood Hits	345	Shared Neighborhood Hits	133
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

PRB3_HUMAN
θ value	θ > 10 (rank : 1553)	NC score	0.086238 (rank : 915)
Query Neighborhood Hits	1407	Target Neighborhood Hits	318	Shared Neighborhood Hits	148
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PRB4S_HUMAN
θ value	θ > 10 (rank : 1554)	NC score	0.089576 (rank : 902)
Query Neighborhood Hits	1407	Target Neighborhood Hits	330	Shared Neighborhood Hits	161
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRG4_HUMAN
θ value	θ > 10 (rank : 1555)	NC score	0.099237 (rank : 881)
Query Neighborhood Hits	1407	Target Neighborhood Hits	764	Shared Neighborhood Hits	265
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_MOUSE
θ value	θ > 10 (rank : 1556)	NC score	0.083264 (rank : 923)
Query Neighborhood Hits	1407	Target Neighborhood Hits	624	Shared Neighborhood Hits	208
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 1557)	NC score	0.098439 (rank : 884)
Query Neighborhood Hits	1407	Target Neighborhood Hits	385	Shared Neighborhood Hits	184
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 1558)	NC score	0.105035 (rank : 871)
Query Neighborhood Hits	1407	Target Neighborhood Hits	347	Shared Neighborhood Hits	180
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRPK_HUMAN
θ value	θ > 10 (rank : 1559)	NC score	0.151655 (rank : 854)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	119
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1560)	NC score	0.154663 (rank : 851)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	125
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRR13_HUMAN
θ value	θ > 10 (rank : 1561)	NC score	0.061548 (rank : 1022)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

RAPH1_HUMAN
θ value	θ > 10 (rank : 1562)	NC score	0.070374 (rank : 960)
Query Neighborhood Hits	1407	Target Neighborhood Hits	593	Shared Neighborhood Hits	247
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 1563)	NC score	0.087066 (rank : 912)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1564)	NC score	0.059093 (rank : 1037)
Query Neighborhood Hits	1407	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1565)	NC score	0.071360 (rank : 954)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RN5A_HUMAN
θ value	θ > 10 (rank : 1566)	NC score	0.153854 (rank : 852)
Query Neighborhood Hits	1407	Target Neighborhood Hits	608	Shared Neighborhood Hits	332
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RN5A_MOUSE
θ value	θ > 10 (rank : 1567)	NC score	0.334801 (rank : 841)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	585
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RPKL1_HUMAN
θ value	θ > 10 (rank : 1568)	NC score	0.647802 (rank : 771)
Query Neighborhood Hits	1407	Target Neighborhood Hits	708	Shared Neighborhood Hits	613
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 1569)	NC score	0.651370 (rank : 769)
Query Neighborhood Hits	1407	Target Neighborhood Hits	704	Shared Neighborhood Hits	623
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 1570)	NC score	0.588194 (rank : 809)
Query Neighborhood Hits	1407	Target Neighborhood Hits	632	Shared Neighborhood Hits	538
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1571)	NC score	0.565174 (rank : 812)
Query Neighborhood Hits	1407	Target Neighborhood Hits	603	Shared Neighborhood Hits	517
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SET1A_HUMAN
θ value	θ > 10 (rank : 1572)	NC score	0.059734 (rank : 1034)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	228
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SF01_HUMAN
θ value	θ > 10 (rank : 1573)	NC score	0.050759 (rank : 1120)
Query Neighborhood Hits	1407	Target Neighborhood Hits	287	Shared Neighborhood Hits	152
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF3A2_HUMAN
θ value	θ > 10 (rank : 1574)	NC score	0.068116 (rank : 979)
Query Neighborhood Hits	1407	Target Neighborhood Hits	263	Shared Neighborhood Hits	145
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SF3A2_MOUSE
θ value	θ > 10 (rank : 1575)	NC score	0.070718 (rank : 959)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	139
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SFPQ_HUMAN
θ value	θ > 10 (rank : 1576)	NC score	0.071021 (rank : 957)
Query Neighborhood Hits	1407	Target Neighborhood Hits	986	Shared Neighborhood Hits	290
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SFR15_HUMAN
θ value	θ > 10 (rank : 1577)	NC score	0.060912 (rank : 1028)
Query Neighborhood Hits	1407	Target Neighborhood Hits	368	Shared Neighborhood Hits	162
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SH21A_HUMAN
θ value	θ > 10 (rank : 1578)	NC score	0.082143 (rank : 925)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1579)	NC score	0.088495 (rank : 907)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1580)	NC score	0.088255 (rank : 909)
Query Neighborhood Hits	1407	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1581)	NC score	0.098992 (rank : 882)
Query Neighborhood Hits	1407	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 1582)	NC score	0.063260 (rank : 1011)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHAN2_MOUSE
θ value	θ > 10 (rank : 1583)	NC score	0.054187 (rank : 1087)
Query Neighborhood Hits	1407	Target Neighborhood Hits	446	Shared Neighborhood Hits	138
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 1584)	NC score	0.055055 (rank : 1074)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	51
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 1585)	NC score	0.057485 (rank : 1049)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 1586)	NC score	0.055432 (rank : 1068)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 1587)	NC score	0.054685 (rank : 1078)
Query Neighborhood Hits	1407	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 1588)	NC score	0.054579 (rank : 1082)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHD_MOUSE
θ value	θ > 10 (rank : 1589)	NC score	0.055270 (rank : 1070)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 1590)	NC score	0.068283 (rank : 976)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1591)	NC score	0.069398 (rank : 969)
Query Neighborhood Hits	1407	Target Neighborhood Hits	169	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 1592)	NC score	0.145680 (rank : 856)
Query Neighborhood Hits	1407	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1593)	NC score	0.143842 (rank : 857)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1594)	NC score	0.147923 (rank : 855)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1595)	NC score	0.152231 (rank : 853)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMR3A_HUMAN
θ value	θ > 10 (rank : 1596)	NC score	0.050050 (rank : 1128)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

SPN90_HUMAN
θ value	θ > 10 (rank : 1597)	NC score	0.061127 (rank : 1025)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 1598)	NC score	0.058368 (rank : 1043)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRRM1_HUMAN
θ value	θ > 10 (rank : 1599)	NC score	0.089526 (rank : 903)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	222
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

STAC3_HUMAN
θ value	θ > 10 (rank : 1600)	NC score	0.104505 (rank : 873)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1601)	NC score	0.104758 (rank : 872)
Query Neighborhood Hits	1407	Target Neighborhood Hits	232	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1602)	NC score	0.095570 (rank : 888)
Query Neighborhood Hits	1407	Target Neighborhood Hits	276	Shared Neighborhood Hits	88
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1603)	NC score	0.102798 (rank : 877)
Query Neighborhood Hits	1407	Target Neighborhood Hits	268	Shared Neighborhood Hits	91
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STK31_HUMAN
θ value	θ > 10 (rank : 1604)	NC score	0.356523 (rank : 839)
Query Neighborhood Hits	1407	Target Neighborhood Hits	570	Shared Neighborhood Hits	352
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1605)	NC score	0.302827 (rank : 844)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	293
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

STYK1_HUMAN
θ value	θ > 10 (rank : 1606)	NC score	0.703569 (rank : 716)
Query Neighborhood Hits	1407	Target Neighborhood Hits	786	Shared Neighborhood Hits	712
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1607)	NC score	0.690085 (rank : 738)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	704
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYN1_HUMAN
θ value	θ > 10 (rank : 1608)	NC score	0.054714 (rank : 1076)
Query Neighborhood Hits	1407	Target Neighborhood Hits	419	Shared Neighborhood Hits	211
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SYN1_MOUSE
θ value	θ > 10 (rank : 1609)	NC score	0.050501 (rank : 1121)
Query Neighborhood Hits	1407	Target Neighborhood Hits	363	Shared Neighborhood Hits	187
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

T22D2_HUMAN
θ value	θ > 10 (rank : 1610)	NC score	0.059470 (rank : 1035)
Query Neighborhood Hits	1407	Target Neighborhood Hits	250	Shared Neighborhood Hits	127
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TCRG1_HUMAN
θ value	θ > 10 (rank : 1611)	NC score	0.050337 (rank : 1124)
Query Neighborhood Hits	1407	Target Neighborhood Hits	929	Shared Neighborhood Hits	192
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 1612)	NC score	0.053960 (rank : 1089)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	198
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TEX14_MOUSE
θ value	θ > 10 (rank : 1613)	NC score	0.535092 (rank : 821)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1333	Shared Neighborhood Hits	629
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIE1_HUMAN
θ value	θ > 10 (rank : 1614)	NC score	0.687280 (rank : 742)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1241	Shared Neighborhood Hits	756
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 1615)	NC score	0.688982 (rank : 740)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1266	Shared Neighborhood Hits	758
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 1616)	NC score	0.705427 (rank : 713)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1192	Shared Neighborhood Hits	752
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 1617)	NC score	0.704657 (rank : 714)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1204	Shared Neighborhood Hits	754
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TRIB1_HUMAN
θ value	θ > 10 (rank : 1618)	NC score	0.698482 (rank : 729)
Query Neighborhood Hits	1407	Target Neighborhood Hits	598	Shared Neighborhood Hits	548
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 1619)	NC score	0.697467 (rank : 732)
Query Neighborhood Hits	1407	Target Neighborhood Hits	593	Shared Neighborhood Hits	550
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB3_HUMAN
θ value	θ > 10 (rank : 1620)	NC score	0.652665 (rank : 768)
Query Neighborhood Hits	1407	Target Neighborhood Hits	519	Shared Neighborhood Hits	493
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 1621)	NC score	0.686117 (rank : 746)
Query Neighborhood Hits	1407	Target Neighborhood Hits	578	Shared Neighborhood Hits	551
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 1622)	NC score	0.660414 (rank : 765)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	675
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 1623)	NC score	0.657915 (rank : 766)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	658
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTK_HUMAN
θ value	θ > 10 (rank : 1624)	NC score	0.837902 (rank : 389)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	701
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TYK2_MOUSE
θ value	θ > 10 (rank : 1625)	NC score	0.794212 (rank : 523)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	745
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UN13A_HUMAN
θ value	θ > 10 (rank : 1626)	NC score	0.069655 (rank : 967)
Query Neighborhood Hits	1407	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1627)	NC score	0.066477 (rank : 992)
Query Neighborhood Hits	1407	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1628)	NC score	0.063961 (rank : 1008)
Query Neighborhood Hits	1407	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1629)	NC score	0.089820 (rank : 901)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	107
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1630)	NC score	0.085578 (rank : 917)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	108
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1631)	NC score	0.093116 (rank : 893)
Query Neighborhood Hits	1407	Target Neighborhood Hits	398	Shared Neighborhood Hits	104
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1632)	NC score	0.092758 (rank : 894)
Query Neighborhood Hits	1407	Target Neighborhood Hits	404	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1633)	NC score	0.089920 (rank : 900)
Query Neighborhood Hits	1407	Target Neighborhood Hits	452	Shared Neighborhood Hits	105
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1634)	NC score	0.084088 (rank : 920)
Query Neighborhood Hits	1407	Target Neighborhood Hits	430	Shared Neighborhood Hits	102
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VGFR1_HUMAN
θ value	θ > 10 (rank : 1635)	NC score	0.630399 (rank : 793)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1109	Shared Neighborhood Hits	738
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1636)	NC score	0.625890 (rank : 797)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	739
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1637)	NC score	0.634344 (rank : 788)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1089	Shared Neighborhood Hits	739
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1638)	NC score	0.635760 (rank : 787)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	733
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1639)	NC score	0.637305 (rank : 784)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	734
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VRK1_HUMAN
θ value	θ > 10 (rank : 1640)	NC score	0.439967 (rank : 836)
Query Neighborhood Hits	1407	Target Neighborhood Hits	584	Shared Neighborhood Hits	532
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 1641)	NC score	0.442938 (rank : 835)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	530
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
θ value	θ > 10 (rank : 1642)	NC score	0.445549 (rank : 834)
Query Neighborhood Hits	1407	Target Neighborhood Hits	582	Shared Neighborhood Hits	521
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_MOUSE
θ value	θ > 10 (rank : 1643)	NC score	0.447514 (rank : 833)
Query Neighborhood Hits	1407	Target Neighborhood Hits	586	Shared Neighborhood Hits	531
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK3_HUMAN
θ value	θ > 10 (rank : 1644)	NC score	0.235046 (rank : 846)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	293
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
θ value	θ > 10 (rank : 1645)	NC score	0.219498 (rank : 849)
Query Neighborhood Hits	1407	Target Neighborhood Hits	342	Shared Neighborhood Hits	287
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WASF2_MOUSE
θ value	θ > 10 (rank : 1646)	NC score	0.053161 (rank : 1096)
Query Neighborhood Hits	1407	Target Neighborhood Hits	315	Shared Neighborhood Hits	179
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WASF4_HUMAN
θ value	θ > 10 (rank : 1647)	NC score	0.050161 (rank : 1127)
Query Neighborhood Hits	1407	Target Neighborhood Hits	282	Shared Neighborhood Hits	161
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASIP_HUMAN
θ value	θ > 10 (rank : 1648)	NC score	0.095513 (rank : 889)
Query Neighborhood Hits	1407	Target Neighborhood Hits	458	Shared Neighborhood Hits	233
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 1649)	NC score	0.087935 (rank : 910)
Query Neighborhood Hits	1407	Target Neighborhood Hits	392	Shared Neighborhood Hits	215
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WASL_HUMAN
θ value	θ > 10 (rank : 1650)	NC score	0.069726 (rank : 966)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	186
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASL_MOUSE
θ value	θ > 10 (rank : 1651)	NC score	0.071492 (rank : 953)
Query Neighborhood Hits	1407	Target Neighborhood Hits	339	Shared Neighborhood Hits	187
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WBP11_HUMAN
θ value	θ > 10 (rank : 1652)	NC score	0.070257 (rank : 961)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	θ > 10 (rank : 1653)	NC score	0.067716 (rank : 984)
Query Neighborhood Hits	1407	Target Neighborhood Hits	362	Shared Neighborhood Hits	165
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

WIRE_HUMAN
θ value	θ > 10 (rank : 1654)	NC score	0.072925 (rank : 950)
Query Neighborhood Hits	1407	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	θ > 10 (rank : 1655)	NC score	0.066478 (rank : 991)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

YLPM1_HUMAN
θ value	θ > 10 (rank : 1656)	NC score	0.066964 (rank : 988)
Query Neighborhood Hits	1407	Target Neighborhood Hits	670	Shared Neighborhood Hits	244
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZN207_HUMAN
θ value	θ > 10 (rank : 1657)	NC score	0.069473 (rank : 968)
Query Neighborhood Hits	1407	Target Neighborhood Hits	326	Shared Neighborhood Hits	113
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

Hits sorted by NC score

WNK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1407	Shared Neighborhood Hits	1407
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

WNK1_HUMAN
NC score	0.969827 (rank : 2)	θ value	2.56852e-180 (rank : 4)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1158	Shared Neighborhood Hits	886
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
NC score	0.967089 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1179	Shared Neighborhood Hits	875
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK3_HUMAN
NC score	0.965377 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	1407	Target Neighborhood Hits	948	Shared Neighborhood Hits	780
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
NC score	0.963387 (rank : 5)	θ value	7.54289e-148 (rank : 5)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1043	Shared Neighborhood Hits	867
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
NC score	0.961894 (rank : 6)	θ value	3.87392e-144 (rank : 6)
Query Neighborhood Hits	1407	Target Neighborhood Hits	961	Shared Neighborhood Hits	822
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

M3K3_HUMAN
NC score	0.908408 (rank : 7)	θ value	1.80048e-24 (rank : 9)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	760
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K2_HUMAN
NC score	0.907863 (rank : 8)	θ value	1.6852e-22 (rank : 19)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	752
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_MOUSE
NC score	0.907748 (rank : 9)	θ value	1.80048e-24 (rank : 10)
Query Neighborhood Hits	1407	Target Neighborhood Hits	876	Shared Neighborhood Hits	758
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

YSK4_HUMAN
NC score	0.906791 (rank : 10)	θ value	7.56453e-23 (rank : 16)
Query Neighborhood Hits	1407	Target Neighborhood Hits	921	Shared Neighborhood Hits	763
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

NEK4_MOUSE
NC score	0.906614 (rank : 11)	θ value	7.56453e-23 (rank : 15)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	763
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK7_MOUSE
NC score	0.906474 (rank : 12)	θ value	3.39556e-23 (rank : 13)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	756
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

M3K2_MOUSE
NC score	0.906306 (rank : 13)	θ value	6.40375e-22 (rank : 21)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	746
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

NEK6_HUMAN
NC score	0.906052 (rank : 14)	θ value	3.07116e-24 (rank : 11)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	756
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.906049 (rank : 15)	θ value	5.79196e-23 (rank : 14)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	756
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
NC score	0.905943 (rank : 16)	θ value	1.99067e-23 (rank : 12)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK2_HUMAN
NC score	0.905169 (rank : 17)	θ value	1.74391e-19 (rank : 50)
Query Neighborhood Hits	1407	Target Neighborhood Hits	908	Shared Neighborhood Hits	760
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK4_HUMAN
NC score	0.904897 (rank : 18)	θ value	9.87957e-23 (rank : 17)
Query Neighborhood Hits	1407	Target Neighborhood Hits	883	Shared Neighborhood Hits	756
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK2_MOUSE
NC score	0.904706 (rank : 19)	θ value	6.85773e-16 (rank : 148)
Query Neighborhood Hits	1407	Target Neighborhood Hits	876	Shared Neighborhood Hits	754
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

M3K4_HUMAN
NC score	0.904530 (rank : 20)	θ value	7.0802e-21 (rank : 32)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
NC score	0.904522 (rank : 21)	θ value	7.0802e-21 (rank : 33)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	770
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K6_HUMAN
NC score	0.904363 (rank : 22)	θ value	1.47631e-18 (rank : 68)
Query Neighborhood Hits	1407	Target Neighborhood Hits	889	Shared Neighborhood Hits	773
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K1_MOUSE
NC score	0.904293 (rank : 23)	θ value	1.24977e-17 (rank : 86)
Query Neighborhood Hits	1407	Target Neighborhood Hits	952	Shared Neighborhood Hits	784
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

OXSR1_HUMAN
NC score	0.903936 (rank : 24)	θ value	7.82807e-20 (rank : 43)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	764
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK2_HUMAN
NC score	0.903849 (rank : 25)	θ value	1.29031e-22 (rank : 18)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	759
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.903367 (rank : 26)	θ value	1.09232e-21 (rank : 23)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

OXSR1_MOUSE
NC score	0.903356 (rank : 27)	θ value	2.97466e-19 (rank : 59)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	758
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_MOUSE
NC score	0.903282 (rank : 28)	θ value	2.27762e-19 (rank : 56)
Query Neighborhood Hits	1407	Target Neighborhood Hits	915	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK39_HUMAN
NC score	0.902700 (rank : 29)	θ value	2.27762e-19 (rank : 55)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

PAK6_HUMAN
NC score	0.902639 (rank : 30)	θ value	9.56915e-18 (rank : 82)
Query Neighborhood Hits	1407	Target Neighborhood Hits	915	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

NEK11_MOUSE
NC score	0.902515 (rank : 31)	θ value	4.02038e-16 (rank : 135)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	756
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK1_HUMAN
NC score	0.902242 (rank : 32)	θ value	3.17815e-21 (rank : 26)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK3_HUMAN
NC score	0.901641 (rank : 33)	θ value	1.2077e-20 (rank : 36)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	763
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

STK25_HUMAN
NC score	0.901594 (rank : 34)	θ value	7.82807e-20 (rank : 44)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	755
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

M3K15_HUMAN
NC score	0.901564 (rank : 35)	θ value	7.0802e-21 (rank : 31)
Query Neighborhood Hits	1407	Target Neighborhood Hits	914	Shared Neighborhood Hits	758
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PAK3_MOUSE
NC score	0.901558 (rank : 36)	θ value	5.42112e-21 (rank : 28)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	759
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

STK4_HUMAN
NC score	0.901434 (rank : 37)	θ value	7.82807e-20 (rank : 45)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	754
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PAK1_MOUSE
NC score	0.901353 (rank : 38)	θ value	3.51386e-20 (rank : 40)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	759
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

STK25_MOUSE
NC score	0.901341 (rank : 39)	θ value	1.33526e-19 (rank : 49)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	755
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK4_MOUSE
NC score	0.901137 (rank : 40)	θ value	7.82807e-20 (rank : 46)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	754
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK3_HUMAN
NC score	0.901076 (rank : 41)	θ value	1.92812e-18 (rank : 72)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	754
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PAK4_HUMAN
NC score	0.900597 (rank : 42)	θ value	1.16975e-15 (rank : 156)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	798
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

STK3_MOUSE
NC score	0.900582 (rank : 43)	θ value	4.29542e-18 (rank : 76)
Query Neighborhood Hits	1407	Target Neighborhood Hits	869	Shared Neighborhood Hits	754
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK24_HUMAN
NC score	0.900521 (rank : 44)	θ value	5.60996e-18 (rank : 77)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	757
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
NC score	0.900366 (rank : 45)	θ value	9.56915e-18 (rank : 84)
Query Neighborhood Hits	1407	Target Neighborhood Hits	856	Shared Neighborhood Hits	757
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NEK11_HUMAN
NC score	0.899822 (rank : 46)	θ value	6.85773e-16 (rank : 147)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1043	Shared Neighborhood Hits	772
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK7_HUMAN
NC score	0.899764 (rank : 47)	θ value	4.02038e-16 (rank : 136)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	758
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

NEK3_MOUSE
NC score	0.899632 (rank : 48)	θ value	2.13179e-17 (rank : 91)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	753
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PAK7_MOUSE
NC score	0.899553 (rank : 49)	θ value	1.80466e-16 (rank : 121)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	759
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

STK36_HUMAN
NC score	0.899331 (rank : 50)	θ value	8.36355e-22 (rank : 22)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	761
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEK1_HUMAN
NC score	0.899242 (rank : 51)	θ value	9.56915e-18 (rank : 81)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1129	Shared Neighborhood Hits	777
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
NC score	0.899084 (rank : 52)	θ value	2.06002e-20 (rank : 37)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1311	Shared Neighborhood Hits	800
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PAK4_MOUSE
NC score	0.899011 (rank : 53)	θ value	4.16044e-13 (rank : 246)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1098	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK3_HUMAN
NC score	0.898864 (rank : 54)	θ value	4.74913e-17 (rank : 105)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	755
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

MST4_MOUSE
NC score	0.898439 (rank : 55)	θ value	3.40345e-15 (rank : 164)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	754
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.898399 (rank : 56)	θ value	2.60593e-15 (rank : 163)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	754
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

E2AK2_MOUSE
NC score	0.897876 (rank : 57)	θ value	1.058e-16 (rank : 113)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	751
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

M3K5_MOUSE
NC score	0.897565 (rank : 58)	θ value	1.47631e-18 (rank : 67)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.897355 (rank : 59)	θ value	8.65492e-19 (rank : 63)
Query Neighborhood Hits	1407	Target Neighborhood Hits	868	Shared Neighborhood Hits	752
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

ULK1_HUMAN
NC score	0.896884 (rank : 60)	θ value	9.24701e-21 (rank : 35)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1121	Shared Neighborhood Hits	844
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
NC score	0.895477 (rank : 61)	θ value	2.06002e-20 (rank : 38)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1214	Shared Neighborhood Hits	877
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK3_HUMAN
NC score	0.895382 (rank : 62)	θ value	7.32683e-18 (rank : 80)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	740
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK36_MOUSE
NC score	0.895063 (rank : 63)	θ value	1.058e-16 (rank : 116)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	759
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ULK2_MOUSE
NC score	0.894895 (rank : 64)	θ value	2.35696e-16 (rank : 126)
Query Neighborhood Hits	1407	Target Neighborhood Hits	943	Shared Neighborhood Hits	785
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

MP2K5_MOUSE
NC score	0.894792 (rank : 65)	θ value	3.76295e-14 (rank : 195)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	749
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

E2AK2_HUMAN
NC score	0.894234 (rank : 66)	θ value	1.68911e-14 (rank : 180)
Query Neighborhood Hits	1407	Target Neighborhood Hits	856	Shared Neighborhood Hits	743
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

MP2K1_HUMAN
NC score	0.894105 (rank : 67)	θ value	3.63628e-17 (rank : 100)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.894039 (rank : 68)	θ value	4.74913e-17 (rank : 104)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	744
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_MOUSE
NC score	0.894019 (rank : 69)	θ value	3.07829e-16 (rank : 130)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	746
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

ULK2_HUMAN
NC score	0.893925 (rank : 70)	θ value	5.25075e-16 (rank : 141)
Query Neighborhood Hits	1407	Target Neighborhood Hits	979	Shared Neighborhood Hits	795
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

MP2K2_HUMAN
NC score	0.893832 (rank : 71)	θ value	4.44505e-15 (rank : 168)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	746
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M4K1_MOUSE
NC score	0.893429 (rank : 72)	θ value	5.8054e-15 (rank : 170)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	759
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

PLK2_HUMAN
NC score	0.893110 (rank : 73)	θ value	5.42112e-21 (rank : 29)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MP2K5_HUMAN
NC score	0.892961 (rank : 74)	θ value	3.52202e-12 (rank : 305)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PLK2_MOUSE
NC score	0.892750 (rank : 75)	θ value	5.42112e-21 (rank : 30)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	755
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

M4K3_HUMAN
NC score	0.892685 (rank : 76)	θ value	9.90251e-15 (rank : 176)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	758
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

AURKC_HUMAN
NC score	0.891846 (rank : 77)	θ value	3.63628e-17 (rank : 99)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	754
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

M4K1_HUMAN
NC score	0.891800 (rank : 78)	θ value	1.09485e-13 (rank : 216)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	764
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

STK6_HUMAN
NC score	0.891757 (rank : 79)	θ value	2.7842e-17 (rank : 96)
Query Neighborhood Hits	1407	Target Neighborhood Hits	916	Shared Neighborhood Hits	769
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
NC score	0.891489 (rank : 80)	θ value	2.5182e-18 (rank : 73)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	764
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

AURKC_MOUSE
NC score	0.891384 (rank : 81)	θ value	8.10077e-17 (rank : 111)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	754
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

M4K2_MOUSE
NC score	0.891341 (rank : 82)	θ value	4.44505e-15 (rank : 167)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	748
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

ULK3_MOUSE
NC score	0.891074 (rank : 83)	θ value	1.02238e-19 (rank : 48)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	754
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

M4K2_HUMAN
NC score	0.890992 (rank : 84)	θ value	5.8054e-15 (rank : 171)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	756
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

NEK8_HUMAN
NC score	0.890893 (rank : 85)	θ value	2.97466e-19 (rank : 58)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	754
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
NC score	0.890525 (rank : 86)	θ value	2.27762e-19 (rank : 52)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	753
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PLK3_MOUSE
NC score	0.890521 (rank : 87)	θ value	9.24701e-21 (rank : 34)
Query Neighborhood Hits	1407	Target Neighborhood Hits	863	Shared Neighborhood Hits	758
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK3_HUMAN
NC score	0.890466 (rank : 88)	θ value	2.69047e-20 (rank : 39)
Query Neighborhood Hits	1407	Target Neighborhood Hits	865	Shared Neighborhood Hits	757
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

TAOK2_HUMAN
NC score	0.889280 (rank : 89)	θ value	6.85773e-16 (rank : 149)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1172	Shared Neighborhood Hits	790
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

PLK4_MOUSE
NC score	0.888769 (rank : 90)	θ value	1.74391e-19 (rank : 51)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	758
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

NIM1_HUMAN
NC score	0.888685 (rank : 91)	θ value	2.27762e-19 (rank : 53)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	752
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PLK4_HUMAN
NC score	0.888523 (rank : 92)	θ value	4.15078e-21 (rank : 27)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	758
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

M4K5_MOUSE
NC score	0.887936 (rank : 93)	θ value	3.76295e-14 (rank : 194)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

PLK1_HUMAN
NC score	0.887670 (rank : 94)	θ value	7.58209e-15 (rank : 173)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	749
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

NIM1_MOUSE
NC score	0.887366 (rank : 95)	θ value	5.07402e-19 (rank : 62)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	751
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

STK33_HUMAN
NC score	0.887224 (rank : 96)	θ value	5.25075e-16 (rank : 140)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	752
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

MP2K7_HUMAN
NC score	0.887135 (rank : 97)	θ value	2.0648e-12 (rank : 288)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	748
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

M4K5_HUMAN
NC score	0.887091 (rank : 98)	θ value	4.91457e-14 (rank : 200)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

PLK1_MOUSE
NC score	0.886618 (rank : 99)	θ value	1.16975e-15 (rank : 157)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	749
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

AURKB_MOUSE
NC score	0.886135 (rank : 100)	θ value	4.91457e-14 (rank : 198)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	758
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKB_HUMAN
NC score	0.886130 (rank : 101)	θ value	2.20605e-14 (rank : 182)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	753
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

NEK9_HUMAN
NC score	0.885934 (rank : 102)	θ value	1.38178e-16 (rank : 119)
Query Neighborhood Hits	1407	Target Neighborhood Hits	900	Shared Neighborhood Hits	760
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

STK11_HUMAN
NC score	0.884932 (rank : 103)	θ value	1.09485e-13 (rank : 217)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

NEK9_MOUSE
NC score	0.884619 (rank : 104)	θ value	5.25075e-16 (rank : 139)
Query Neighborhood Hits	1407	Target Neighborhood Hits	890	Shared Neighborhood Hits	760
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NUAK1_HUMAN
NC score	0.884601 (rank : 105)	θ value	1.42992e-13 (rank : 224)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	760
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

CHK1_MOUSE
NC score	0.884460 (rank : 106)	θ value	1.47974e-10 (rank : 406)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	747
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MP2K6_MOUSE
NC score	0.884452 (rank : 107)	θ value	4.16044e-13 (rank : 245)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	744
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

CHK1_HUMAN
NC score	0.884394 (rank : 108)	θ value	1.47974e-10 (rank : 405)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	746
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MP2K4_HUMAN
NC score	0.883924 (rank : 109)	θ value	1.86753e-13 (rank : 230)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	751
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MARK4_HUMAN
NC score	0.883873 (rank : 110)	θ value	4.74913e-17 (rank : 102)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	769
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MP2K6_HUMAN
NC score	0.883824 (rank : 111)	θ value	3.18553e-13 (rank : 242)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	743
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K4_MOUSE
NC score	0.883807 (rank : 112)	θ value	1.86753e-13 (rank : 231)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MARK4_MOUSE
NC score	0.883686 (rank : 113)	θ value	4.74913e-17 (rank : 103)
Query Neighborhood Hits	1407	Target Neighborhood Hits	898	Shared Neighborhood Hits	769
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NUAK1_MOUSE
NC score	0.883534 (rank : 114)	θ value	3.76295e-14 (rank : 196)
Query Neighborhood Hits	1407	Target Neighborhood Hits	881	Shared Neighborhood Hits	765
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
NC score	0.883170 (rank : 115)	θ value	8.95645e-16 (rank : 152)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	759
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

BRSK2_HUMAN
NC score	0.882875 (rank : 116)	θ value	1.92812e-18 (rank : 71)
Query Neighborhood Hits	1407	Target Neighborhood Hits	897	Shared Neighborhood Hits	772
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

AAPK1_HUMAN
NC score	0.882809 (rank : 117)	θ value	3.18553e-13 (rank : 236)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

MARK2_HUMAN
NC score	0.882620 (rank : 118)	θ value	1.058e-16 (rank : 115)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	811
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

TSSK4_MOUSE
NC score	0.882487 (rank : 119)	θ value	3.89403e-11 (rank : 368)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	745
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

AAPK1_MOUSE
NC score	0.882455 (rank : 120)	θ value	3.18553e-13 (rank : 237)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	749
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

SN1L2_HUMAN
NC score	0.882204 (rank : 121)	θ value	1.16975e-15 (rank : 158)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	818
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

HUNK_MOUSE
NC score	0.882146 (rank : 122)	θ value	6.41864e-14 (rank : 205)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	757
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

TSSK4_HUMAN
NC score	0.882129 (rank : 123)	θ value	5.08577e-11 (rank : 376)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	747
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

HUNK_HUMAN
NC score	0.882010 (rank : 124)	θ value	2.88119e-14 (rank : 186)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	759
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

MARK1_MOUSE
NC score	0.881846 (rank : 125)	θ value	5.25075e-16 (rank : 138)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	762
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

BRSK1_HUMAN
NC score	0.881830 (rank : 126)	θ value	1.47631e-18 (rank : 66)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	785
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

MARK3_MOUSE
NC score	0.881788 (rank : 127)	θ value	4.02038e-16 (rank : 134)
Query Neighborhood Hits	1407	Target Neighborhood Hits	919	Shared Neighborhood Hits	771
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK1_HUMAN
NC score	0.881510 (rank : 128)	θ value	1.38178e-16 (rank : 118)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	758
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

SN1L2_MOUSE
NC score	0.881509 (rank : 129)	θ value	8.95645e-16 (rank : 153)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	806
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MP2K3_MOUSE
NC score	0.881476 (rank : 130)	θ value	6.41864e-14 (rank : 212)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MARK2_MOUSE
NC score	0.881214 (rank : 131)	θ value	9.90251e-15 (rank : 177)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1018	Shared Neighborhood Hits	804
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

NUAK2_MOUSE
NC score	0.880888 (rank : 132)	θ value	3.76295e-14 (rank : 197)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	756
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

K0999_MOUSE
NC score	0.880473 (rank : 133)	θ value	2.7842e-17 (rank : 93)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	772
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_HUMAN
NC score	0.880454 (rank : 134)	θ value	2.7842e-17 (rank : 92)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

ST17B_MOUSE
NC score	0.879916 (rank : 135)	θ value	1.42992e-13 (rank : 226)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	739
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

IKKB_HUMAN
NC score	0.879908 (rank : 136)	θ value	6.41864e-14 (rank : 206)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	755
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KKCC2_HUMAN
NC score	0.879747 (rank : 137)	θ value	3.76295e-14 (rank : 191)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	749
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
NC score	0.879744 (rank : 138)	θ value	3.76295e-14 (rank : 192)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	751
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

NRK_HUMAN
NC score	0.879462 (rank : 139)	θ value	6.41864e-14 (rank : 213)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	753
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

SN1L1_MOUSE
NC score	0.879426 (rank : 140)	θ value	9.90251e-15 (rank : 178)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	768
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

MP2K3_HUMAN
NC score	0.879292 (rank : 141)	θ value	5.43371e-13 (rank : 250)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	742
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

NRK_MOUSE
NC score	0.879171 (rank : 142)	θ value	1.2105e-12 (rank : 275)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	756
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

AAPK2_HUMAN
NC score	0.879125 (rank : 143)	θ value	1.58096e-12 (rank : 279)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	749
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

IKKE_HUMAN
NC score	0.878871 (rank : 144)	θ value	2.79066e-09 (rank : 486)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	736
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKA_MOUSE
NC score	0.878844 (rank : 145)	θ value	1.2105e-12 (rank : 270)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SN1L1_HUMAN
NC score	0.878764 (rank : 146)	θ value	2.88119e-14 (rank : 189)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	776
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

IKKE_MOUSE
NC score	0.878523 (rank : 147)	θ value	1.63604e-09 (rank : 468)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	739
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M3K14_HUMAN
NC score	0.878107 (rank : 148)	θ value	6.64225e-11 (rank : 388)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	768
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

PDK1L_HUMAN
NC score	0.877930 (rank : 149)	θ value	1.9326e-10 (rank : 418)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	743
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

SNRK_HUMAN
NC score	0.877717 (rank : 150)	θ value	7.58209e-15 (rank : 174)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MINK1_HUMAN
NC score	0.877642 (rank : 151)	θ value	1.99529e-15 (rank : 161)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1477	Shared Neighborhood Hits	846
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

IKKA_HUMAN
NC score	0.877623 (rank : 152)	θ value	7.09661e-13 (rank : 256)
Query Neighborhood Hits	1407	Target Neighborhood Hits	863	Shared Neighborhood Hits	747
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SNRK_MOUSE
NC score	0.877521 (rank : 153)	θ value	1.86753e-13 (rank : 232)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	739
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PDK1L_MOUSE
NC score	0.877443 (rank : 154)	θ value	1.9326e-10 (rank : 419)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	743
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

DAPK3_MOUSE
NC score	0.877432 (rank : 155)	θ value	1.80466e-16 (rank : 120)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	737
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

MINK1_MOUSE
NC score	0.877197 (rank : 156)	θ value	1.16975e-15 (rank : 155)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1451	Shared Neighborhood Hits	831
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

KKCC1_MOUSE
NC score	0.877121 (rank : 157)	θ value	1.42992e-13 (rank : 221)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	755
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

M3K13_HUMAN
NC score	0.877037 (rank : 158)	θ value	7.32683e-18 (rank : 78)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	767
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

KKCC1_HUMAN
NC score	0.876570 (rank : 159)	θ value	6.41864e-14 (rank : 207)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	753
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

IKKB_MOUSE
NC score	0.876340 (rank : 160)	θ value	5.43371e-13 (rank : 247)
Query Neighborhood Hits	1407	Target Neighborhood Hits	984	Shared Neighborhood Hits	751
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

TAOK2_MOUSE
NC score	0.876259 (rank : 161)	θ value	2.35696e-16 (rank : 125)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1373	Shared Neighborhood Hits	801
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

DAPK3_HUMAN
NC score	0.876148 (rank : 162)	θ value	8.10077e-17 (rank : 112)
Query Neighborhood Hits	1407	Target Neighborhood Hits	945	Shared Neighborhood Hits	741
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

TNIK_HUMAN
NC score	0.875817 (rank : 163)	θ value	1.63225e-17 (rank : 88)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1570	Shared Neighborhood Hits	837
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

DAPK2_MOUSE
NC score	0.875708 (rank : 164)	θ value	6.20254e-17 (rank : 107)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	740
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST17B_HUMAN
NC score	0.874585 (rank : 165)	θ value	2.0648e-12 (rank : 289)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	735
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KPCD2_HUMAN
NC score	0.874539 (rank : 166)	θ value	1.13037e-18 (rank : 65)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	748
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

TLK1_HUMAN
NC score	0.874171 (rank : 167)	θ value	3.07829e-16 (rank : 131)
Query Neighborhood Hits	1407	Target Neighborhood Hits	967	Shared Neighborhood Hits	732
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.874047 (rank : 168)	θ value	3.07829e-16 (rank : 132)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	728
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

MARK3_HUMAN
NC score	0.873849 (rank : 169)	θ value	4.59992e-12 (rank : 310)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	759
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

ST17A_HUMAN
NC score	0.873790 (rank : 170)	θ value	9.56915e-18 (rank : 83)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	731
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

PHKG2_MOUSE
NC score	0.873042 (rank : 171)	θ value	4.91457e-14 (rank : 203)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	747
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

MYLK2_HUMAN
NC score	0.872693 (rank : 172)	θ value	1.33837e-11 (rank : 339)
Query Neighborhood Hits	1407	Target Neighborhood Hits	920	Shared Neighborhood Hits	772
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PMYT1_MOUSE
NC score	0.872690 (rank : 173)	θ value	6.00763e-12 (rank : 316)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	764
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

STK35_HUMAN
NC score	0.872646 (rank : 174)	θ value	2.13673e-09 (rank : 480)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	738
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

PHKG1_HUMAN
NC score	0.872568 (rank : 175)	θ value	4.91457e-14 (rank : 201)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	748
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

M3K14_MOUSE
NC score	0.872557 (rank : 176)	θ value	3.29651e-10 (rank : 430)
Query Neighborhood Hits	1407	Target Neighborhood Hits	889	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

TLK2_HUMAN
NC score	0.872237 (rank : 177)	θ value	2.7842e-17 (rank : 97)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1044	Shared Neighborhood Hits	742
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

KPCD1_HUMAN
NC score	0.872232 (rank : 178)	θ value	2.7842e-17 (rank : 94)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	742
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
NC score	0.872106 (rank : 179)	θ value	2.7842e-17 (rank : 95)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	742
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

DAPK2_HUMAN
NC score	0.871631 (rank : 180)	θ value	5.25075e-16 (rank : 137)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	736
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

TESK1_MOUSE
NC score	0.871495 (rank : 181)	θ value	1.58096e-12 (rank : 283)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	764
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

IRAK4_MOUSE
NC score	0.871011 (rank : 182)	θ value	3.76295e-14 (rank : 190)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	735
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

PHKG2_HUMAN
NC score	0.870918 (rank : 183)	θ value	4.91457e-14 (rank : 202)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	746
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

M3K12_HUMAN
NC score	0.870867 (rank : 184)	θ value	8.95645e-16 (rank : 150)
Query Neighborhood Hits	1407	Target Neighborhood Hits	940	Shared Neighborhood Hits	784
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K8_HUMAN
NC score	0.870656 (rank : 185)	θ value	2.36244e-08 (rank : 542)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	720
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TESK1_HUMAN
NC score	0.870609 (rank : 186)	θ value	1.58096e-12 (rank : 282)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	762
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K12_MOUSE
NC score	0.870589 (rank : 187)	θ value	8.95645e-16 (rank : 151)
Query Neighborhood Hits	1407	Target Neighborhood Hits	957	Shared Neighborhood Hits	780
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

TSSK1_MOUSE
NC score	0.870496 (rank : 188)	θ value	1.47974e-10 (rank : 413)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	741
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

M3K7_MOUSE
NC score	0.870285 (rank : 189)	θ value	6.85773e-16 (rank : 146)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	754
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_MOUSE
NC score	0.870269 (rank : 190)	θ value	6.87365e-08 (rank : 568)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	721
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TSSK2_HUMAN
NC score	0.870255 (rank : 191)	θ value	9.26847e-13 (rank : 269)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	738
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

DCAK3_HUMAN
NC score	0.870100 (rank : 192)	θ value	7.09661e-13 (rank : 255)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	752
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

TBK1_HUMAN
NC score	0.870076 (rank : 193)	θ value	6.87365e-08 (rank : 572)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	733
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

M3K7_HUMAN
NC score	0.870053 (rank : 194)	θ value	6.85773e-16 (rank : 145)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	753
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

CHK2_MOUSE
NC score	0.870034 (rank : 195)	θ value	7.84624e-12 (rank : 321)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

ULK4_MOUSE
NC score	0.869920 (rank : 196)	θ value	3.52202e-12 (rank : 306)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	706
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

TLK2_MOUSE
NC score	0.869832 (rank : 197)	θ value	2.7842e-17 (rank : 98)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1088	Shared Neighborhood Hits	740
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

KPCD3_HUMAN
NC score	0.869711 (rank : 198)	θ value	1.63225e-17 (rank : 87)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	742
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

DCAK3_MOUSE
NC score	0.869668 (rank : 199)	θ value	5.08577e-11 (rank : 371)
Query Neighborhood Hits	1407	Target Neighborhood Hits	922	Shared Neighborhood Hits	753
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KPCD3_MOUSE
NC score	0.869466 (rank : 200)	θ value	1.24977e-17 (rank : 85)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	740
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

PHKG1_MOUSE
NC score	0.869443 (rank : 201)	θ value	5.08577e-11 (rank : 374)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	747
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TBK1_MOUSE
NC score	0.869072 (rank : 202)	θ value	8.97725e-08 (rank : 579)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	734
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

CHK2_HUMAN
NC score	0.868679 (rank : 203)	θ value	1.02475e-11 (rank : 330)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	743
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

KCC1B_MOUSE
NC score	0.868359 (rank : 204)	θ value	1.2105e-12 (rank : 271)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1B_HUMAN
NC score	0.868169 (rank : 205)	θ value	5.43371e-13 (rank : 248)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

BRAF1_HUMAN
NC score	0.868051 (rank : 206)	θ value	4.9032e-22 (rank : 20)
Query Neighborhood Hits	1407	Target Neighborhood Hits	883	Shared Neighborhood Hits	755
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

KCC1G_HUMAN
NC score	0.868025 (rank : 207)	θ value	4.74913e-17 (rank : 101)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	744
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC4_MOUSE
NC score	0.867984 (rank : 208)	θ value	2.20605e-14 (rank : 183)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	752
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1G_MOUSE
NC score	0.867961 (rank : 209)	θ value	6.85773e-16 (rank : 144)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	748
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KPSH1_MOUSE
NC score	0.867935 (rank : 210)	θ value	1.86753e-13 (rank : 229)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	743
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

SLK_MOUSE
NC score	0.867710 (rank : 211)	θ value	2.43343e-21 (rank : 25)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1798	Shared Neighborhood Hits	819
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

PMYT1_HUMAN
NC score	0.867563 (rank : 212)	θ value	1.33837e-11 (rank : 340)
Query Neighborhood Hits	1407	Target Neighborhood Hits	814	Shared Neighborhood Hits	734
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KCC4_HUMAN
NC score	0.867559 (rank : 213)	θ value	3.18553e-13 (rank : 241)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	742
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KPSH1_HUMAN
NC score	0.867443 (rank : 214)	θ value	6.41864e-14 (rank : 209)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	745
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

TAOK3_MOUSE
NC score	0.867427 (rank : 215)	θ value	2.5182e-18 (rank : 74)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1458	Shared Neighborhood Hits	783
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

IRAK4_HUMAN
NC score	0.867415 (rank : 216)	θ value	1.42992e-13 (rank : 218)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	736
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

PDPK1_HUMAN
NC score	0.866672 (rank : 217)	θ value	4.59992e-12 (rank : 311)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	751
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
NC score	0.866391 (rank : 218)	θ value	7.84624e-12 (rank : 328)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	749
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

SBK1_MOUSE
NC score	0.866275 (rank : 219)	θ value	3.08544e-08 (rank : 555)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	733
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

RAF1_HUMAN
NC score	0.866128 (rank : 220)	θ value	3.51386e-20 (rank : 41)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	756
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CDKL3_MOUSE
NC score	0.866098 (rank : 221)	θ value	3.52202e-12 (rank : 300)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	751
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KCC2G_MOUSE
NC score	0.866082 (rank : 222)	θ value	6.20254e-17 (rank : 109)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	743
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.866080 (rank : 223)	θ value	6.20254e-17 (rank : 108)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	742
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PRKY_HUMAN
NC score	0.866076 (rank : 224)	θ value	1.2105e-12 (rank : 277)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	754
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

CDKL3_HUMAN
NC score	0.865825 (rank : 225)	θ value	3.52202e-12 (rank : 299)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	749
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

RAF1_MOUSE
NC score	0.865747 (rank : 226)	θ value	2.27762e-19 (rank : 54)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	760
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SLK_HUMAN
NC score	0.865649 (rank : 227)	θ value	2.43343e-21 (rank : 24)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1775	Shared Neighborhood Hits	814
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KCC1A_MOUSE
NC score	0.865533 (rank : 228)	θ value	2.0648e-12 (rank : 287)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	747
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
NC score	0.865268 (rank : 229)	θ value	4.59992e-12 (rank : 309)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	747
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC2D_HUMAN
NC score	0.865018 (rank : 230)	θ value	2.13179e-17 (rank : 89)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	741
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

TESK2_MOUSE
NC score	0.864928 (rank : 231)	θ value	2.13673e-09 (rank : 481)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TSSK1_HUMAN
NC score	0.864899 (rank : 232)	θ value	1.47974e-10 (rank : 412)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	738
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

PASK_MOUSE
NC score	0.864862 (rank : 233)	θ value	1.99992e-07 (rank : 594)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	744
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

TAOK3_HUMAN
NC score	0.864797 (rank : 234)	θ value	2.27762e-19 (rank : 57)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1494	Shared Neighborhood Hits	788
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

KCC2A_HUMAN
NC score	0.864700 (rank : 235)	θ value	1.38178e-16 (rank : 117)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	739
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

E2AK1_HUMAN
NC score	0.864642 (rank : 236)	θ value	1.47974e-10 (rank : 407)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	739
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

TSSK3_MOUSE
NC score	0.864410 (rank : 237)	θ value	4.76016e-09 (rank : 507)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	723
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

E2AK1_MOUSE
NC score	0.864294 (rank : 238)	θ value	3.64472e-09 (rank : 493)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	738
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

KCC1D_HUMAN
NC score	0.864173 (rank : 239)	θ value	9.26847e-13 (rank : 263)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	744
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

TSSK2_MOUSE
NC score	0.864046 (rank : 240)	θ value	7.09661e-13 (rank : 259)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	732
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

KCC1D_MOUSE
NC score	0.864026 (rank : 241)	θ value	1.2105e-12 (rank : 272)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

TESK2_HUMAN
NC score	0.864012 (rank : 242)	θ value	2.79066e-09 (rank : 489)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	745
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

SBK1_HUMAN
NC score	0.863834 (rank : 243)	θ value	8.97725e-08 (rank : 578)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	734
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ST32A_MOUSE
NC score	0.863780 (rank : 244)	θ value	5.08577e-11 (rank : 375)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

TSSK3_HUMAN
NC score	0.863736 (rank : 245)	θ value	6.21693e-09 (rank : 513)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	723
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CDK3_MOUSE
NC score	0.863729 (rank : 246)	θ value	2.13673e-09 (rank : 473)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

TSSK6_MOUSE
NC score	0.863535 (rank : 247)	θ value	1.17247e-07 (rank : 585)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	735
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_HUMAN
NC score	0.863334 (rank : 248)	θ value	1.99992e-07 (rank : 599)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	736
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CDKL4_MOUSE
NC score	0.863224 (rank : 249)	θ value	6.00763e-12 (rank : 313)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	744
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDC2_HUMAN
NC score	0.863114 (rank : 250)	θ value	3.18553e-13 (rank : 238)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	754
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KCC2B_HUMAN
NC score	0.862848 (rank : 251)	θ value	2.35696e-16 (rank : 124)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	756
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

CDC2_MOUSE
NC score	0.862799 (rank : 252)	θ value	3.18553e-13 (rank : 239)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	751
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KCC2A_MOUSE
NC score	0.862211 (rank : 253)	θ value	2.60593e-15 (rank : 162)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	737
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KPSH2_HUMAN
NC score	0.862023 (rank : 254)	θ value	4.30538e-10 (rank : 441)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	731
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

ST32A_HUMAN
NC score	0.861980 (rank : 255)	θ value	1.74796e-11 (rank : 345)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	741
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

M4K4_MOUSE
NC score	0.861531 (rank : 256)	θ value	1.02475e-11 (rank : 332)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1560	Shared Neighborhood Hits	802
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PASK_HUMAN
NC score	0.861428 (rank : 257)	θ value	1.80886e-08 (rank : 537)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	741
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

STK16_MOUSE
NC score	0.861069 (rank : 258)	θ value	7.1131e-05 (rank : 693)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	737
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

MLTK_MOUSE
NC score	0.861064 (rank : 259)	θ value	5.07402e-19 (rank : 61)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	749
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

M4K4_HUMAN
NC score	0.860905 (rank : 260)	θ value	5.43371e-13 (rank : 249)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1589	Shared Neighborhood Hits	794
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MLTK_HUMAN
NC score	0.860823 (rank : 261)	θ value	8.65492e-19 (rank : 64)
Query Neighborhood Hits	1407	Target Neighborhood Hits	911	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

CDKL2_MOUSE
NC score	0.860660 (rank : 262)	θ value	2.69671e-12 (rank : 292)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	748
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

ARAF_HUMAN
NC score	0.860646 (rank : 263)	θ value	3.28887e-18 (rank : 75)
Query Neighborhood Hits	1407	Target Neighborhood Hits	924	Shared Neighborhood Hits	768
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

CDKL4_HUMAN
NC score	0.860282 (rank : 264)	θ value	8.67504e-11 (rank : 393)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	742
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KCC2B_MOUSE
NC score	0.860086 (rank : 265)	θ value	4.02038e-16 (rank : 133)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	740
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

DCAK2_MOUSE
NC score	0.859980 (rank : 266)	θ value	4.44505e-15 (rank : 165)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	744
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

MELK_MOUSE
NC score	0.859646 (rank : 267)	θ value	6.64225e-11 (rank : 389)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	752
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

ARAF_MOUSE
NC score	0.859588 (rank : 268)	θ value	6.20254e-17 (rank : 106)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CDKL2_HUMAN
NC score	0.859318 (rank : 269)	θ value	1.02475e-11 (rank : 329)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	746
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

DCAK2_HUMAN
NC score	0.859051 (rank : 270)	θ value	5.8054e-15 (rank : 169)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	745
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

E2AK4_HUMAN
NC score	0.858989 (rank : 271)	θ value	1.80886e-08 (rank : 535)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1012	Shared Neighborhood Hits	766
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

ST32B_MOUSE
NC score	0.858871 (rank : 272)	θ value	3.29651e-10 (rank : 433)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	740
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

MOS_MOUSE
NC score	0.858581 (rank : 273)	θ value	5.81887e-07 (rank : 624)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	752
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ERN1_HUMAN
NC score	0.858311 (rank : 274)	θ value	2.0648e-12 (rank : 286)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	735
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MELK_HUMAN
NC score	0.858209 (rank : 275)	θ value	θ > 10 (rank : 1516)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	749
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

E2AK4_MOUSE
NC score	0.857846 (rank : 276)	θ value	1.9326e-10 (rank : 415)
Query Neighborhood Hits	1407	Target Neighborhood Hits	984	Shared Neighborhood Hits	763
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

ST32B_HUMAN
NC score	0.857644 (rank : 277)	θ value	2.52405e-10 (rank : 422)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	741
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

M3K10_HUMAN
NC score	0.856958 (rank : 278)	θ value	5.07402e-19 (rank : 60)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1071	Shared Neighborhood Hits	780
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

STK16_HUMAN
NC score	0.856888 (rank : 279)	θ value	0.00035302 (rank : 720)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	739
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

DCAK1_MOUSE
NC score	0.856297 (rank : 280)	θ value	3.52202e-12 (rank : 301)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	746
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CDK2_HUMAN
NC score	0.856263 (rank : 281)	θ value	7.84624e-12 (rank : 320)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	749
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

DCAK1_HUMAN
NC score	0.856114 (rank : 282)	θ value	6.64225e-11 (rank : 379)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	751
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CDK2_MOUSE
NC score	0.856014 (rank : 283)	θ value	6.64225e-11 (rank : 378)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	745
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

PRKX_HUMAN
NC score	0.855917 (rank : 284)	θ value	1.58096e-12 (rank : 281)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	752
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

MOS_HUMAN
NC score	0.855833 (rank : 285)	θ value	5.44631e-05 (rank : 687)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	750
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CDK3_HUMAN
NC score	0.855573 (rank : 286)	θ value	4.16044e-13 (rank : 244)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	748
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

SGK1_HUMAN
NC score	0.855361 (rank : 287)	θ value	2.43908e-13 (rank : 235)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	753
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

CDKL1_MOUSE
NC score	0.855197 (rank : 288)	θ value	9.59137e-10 (rank : 455)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

PRKX_MOUSE
NC score	0.855052 (rank : 289)	θ value	1.74796e-11 (rank : 344)
Query Neighborhood Hits	1407	Target Neighborhood Hits	846	Shared Neighborhood Hits	754
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

RIPK5_HUMAN
NC score	0.855003 (rank : 290)	θ value	2.98157e-11 (rank : 359)
Query Neighborhood Hits	1407	Target Neighborhood Hits	864	Shared Neighborhood Hits	754
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
NC score	0.854949 (rank : 291)	θ value	2.98157e-11 (rank : 360)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	754
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

CDKL1_HUMAN
NC score	0.854899 (rank : 292)	θ value	7.34386e-10 (rank : 453)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	745
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

SGK1_MOUSE
NC score	0.854819 (rank : 293)	θ value	7.09661e-13 (rank : 257)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	755
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

ERN1_MOUSE
NC score	0.854817 (rank : 294)	θ value	1.02475e-11 (rank : 331)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	735
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KSR2_HUMAN
NC score	0.854747 (rank : 295)	θ value	5.62301e-10 (rank : 451)
Query Neighborhood Hits	1407	Target Neighborhood Hits	920	Shared Neighborhood Hits	777
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RIPK1_HUMAN
NC score	0.854506 (rank : 296)	θ value	4.76016e-09 (rank : 506)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	757
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

M3K11_HUMAN
NC score	0.854239 (rank : 297)	θ value	1.058e-16 (rank : 114)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1136	Shared Neighborhood Hits	831
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PFTK1_HUMAN
NC score	0.853941 (rank : 298)	θ value	5.43371e-13 (rank : 251)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	742
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

ST32C_MOUSE
NC score	0.853781 (rank : 299)	θ value	1.06045e-08 (rank : 526)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	738
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

PFTK1_MOUSE
NC score	0.853604 (rank : 300)	θ value	1.2105e-12 (rank : 276)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	742
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KAPCG_HUMAN
NC score	0.853465 (rank : 301)	θ value	1.42992e-13 (rank : 220)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	751
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

RIPK3_MOUSE
NC score	0.853438 (rank : 302)	θ value	1.53129e-07 (rank : 588)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	757
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

CDK7_MOUSE
NC score	0.852574 (rank : 303)	θ value	5.62301e-10 (rank : 447)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK7_HUMAN
NC score	0.851961 (rank : 304)	θ value	5.62301e-10 (rank : 446)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	747
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

KS6A2_HUMAN
NC score	0.851904 (rank : 305)	θ value	9.26847e-13 (rank : 264)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	759
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
NC score	0.851669 (rank : 306)	θ value	3.52202e-12 (rank : 303)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	757
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

AKT3_HUMAN
NC score	0.851275 (rank : 307)	θ value	1.52774e-15 (rank : 159)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	748
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.851248 (rank : 308)	θ value	1.52774e-15 (rank : 160)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

ST32C_HUMAN
NC score	0.850834 (rank : 309)	θ value	5.26297e-08 (rank : 563)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	741
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

E2AK3_MOUSE
NC score	0.850754 (rank : 310)	θ value	3.08544e-08 (rank : 548)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	747
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

RIPK3_HUMAN
NC score	0.850681 (rank : 311)	θ value	8.11959e-09 (rank : 520)
Query Neighborhood Hits	1407	Target Neighborhood Hits	828	Shared Neighborhood Hits	743
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

TAOK1_MOUSE
NC score	0.850647 (rank : 312)	θ value	1.47631e-18 (rank : 70)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1720	Shared Neighborhood Hits	806
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

M3K9_HUMAN
NC score	0.850528 (rank : 313)	θ value	3.76295e-14 (rank : 193)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	795
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SGK2_MOUSE
NC score	0.850312 (rank : 314)	θ value	7.34386e-10 (rank : 454)
Query Neighborhood Hits	1407	Target Neighborhood Hits	833	Shared Neighborhood Hits	747
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KS6A1_HUMAN
NC score	0.850285 (rank : 315)	θ value	1.42992e-13 (rank : 222)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	756
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

TAOK1_HUMAN
NC score	0.850272 (rank : 316)	θ value	1.47631e-18 (rank : 69)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1734	Shared Neighborhood Hits	809
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

AKT2_HUMAN
NC score	0.849604 (rank : 317)	θ value	1.16975e-15 (rank : 154)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	747
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KS6A3_MOUSE
NC score	0.849599 (rank : 318)	θ value	9.26847e-13 (rank : 266)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	760
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.849579 (rank : 319)	θ value	9.26847e-13 (rank : 265)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	760
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6B2_HUMAN
NC score	0.849424 (rank : 320)	θ value	7.84624e-12 (rank : 323)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	760
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KAPCA_HUMAN
NC score	0.849358 (rank : 321)	θ value	4.44505e-15 (rank : 166)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

RIPK1_MOUSE
NC score	0.849127 (rank : 322)	θ value	9.92553e-07 (rank : 633)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	757
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ICK_MOUSE
NC score	0.848905 (rank : 323)	θ value	2.98157e-11 (rank : 350)
Query Neighborhood Hits	1407	Target Neighborhood Hits	860	Shared Neighborhood Hits	751
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

AKT2_MOUSE
NC score	0.848794 (rank : 324)	θ value	7.58209e-15 (rank : 172)
Query Neighborhood Hits	1407	Target Neighborhood Hits	875	Shared Neighborhood Hits	747
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CDK6_MOUSE
NC score	0.848764 (rank : 325)	θ value	4.59992e-12 (rank : 307)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

AL2S7_HUMAN
NC score	0.848730 (rank : 326)	θ value	3.52202e-12 (rank : 296)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	743
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

KAPCA_MOUSE
NC score	0.848690 (rank : 327)	θ value	9.90251e-15 (rank : 175)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

CD2L7_HUMAN
NC score	0.848278 (rank : 328)	θ value	1.47974e-10 (rank : 404)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1275	Shared Neighborhood Hits	912
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

KS6A6_HUMAN
NC score	0.848269 (rank : 329)	θ value	3.52202e-12 (rank : 304)
Query Neighborhood Hits	1407	Target Neighborhood Hits	853	Shared Neighborhood Hits	753
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

SGK2_HUMAN
NC score	0.848189 (rank : 330)	θ value	1.9326e-10 (rank : 420)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ICK_HUMAN
NC score	0.847922 (rank : 331)	θ value	2.98157e-11 (rank : 349)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	751
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

E2AK3_HUMAN
NC score	0.847761 (rank : 332)	θ value	3.77169e-06 (rank : 653)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	743
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

KAPCB_MOUSE
NC score	0.847468 (rank : 333)	θ value	1.29331e-14 (rank : 179)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	748
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

CDK6_HUMAN
NC score	0.847442 (rank : 334)	θ value	6.00763e-12 (rank : 312)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

KAPCB_HUMAN
NC score	0.847338 (rank : 335)	θ value	4.91457e-14 (rank : 199)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

PCTK3_MOUSE
NC score	0.847284 (rank : 336)	θ value	2.69671e-12 (rank : 293)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	744
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

STK10_HUMAN
NC score	0.847227 (rank : 337)	θ value	6.20254e-17 (rank : 110)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1921	Shared Neighborhood Hits	845
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MAPK2_HUMAN
NC score	0.847118 (rank : 338)	θ value	9.59137e-10 (rank : 459)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	739
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

RK_MOUSE
NC score	0.847000 (rank : 339)	θ value	1.02475e-11 (rank : 333)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	742
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

SGK3_MOUSE
NC score	0.846867 (rank : 340)	θ value	1.42992e-13 (rank : 225)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	748
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

KS6B2_MOUSE
NC score	0.846854 (rank : 341)	θ value	3.89403e-11 (rank : 362)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	768
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

MAK_MOUSE
NC score	0.846792 (rank : 342)	θ value	3.89403e-11 (rank : 364)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	759
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

AKT1_HUMAN
NC score	0.846542 (rank : 343)	θ value	6.85773e-16 (rank : 142)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	751
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

SGK3_HUMAN
NC score	0.846541 (rank : 344)	θ value	2.69671e-12 (rank : 295)
Query Neighborhood Hits	1407	Target Neighborhood Hits	877	Shared Neighborhood Hits	748
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

CDK5_HUMAN
NC score	0.846515 (rank : 345)	θ value	3.52202e-12 (rank : 297)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

AKT1_MOUSE
NC score	0.846482 (rank : 346)	θ value	3.07829e-16 (rank : 127)
Query Neighborhood Hits	1407	Target Neighborhood Hits	878	Shared Neighborhood Hits	751
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CDK5_MOUSE
NC score	0.846443 (rank : 347)	θ value	3.52202e-12 (rank : 298)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	742
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

PCTK1_MOUSE
NC score	0.846081 (rank : 348)	θ value	1.47974e-10 (rank : 411)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	746
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

KS6A1_MOUSE
NC score	0.846039 (rank : 349)	θ value	1.58096e-12 (rank : 280)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	753
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PCTK1_HUMAN
NC score	0.845935 (rank : 350)	θ value	1.9326e-10 (rank : 417)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	748
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK2_HUMAN
NC score	0.845897 (rank : 351)	θ value	7.84624e-12 (rank : 325)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	746
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
NC score	0.845802 (rank : 352)	θ value	7.84624e-12 (rank : 326)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	746
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

KS6B1_HUMAN
NC score	0.845719 (rank : 353)	θ value	6.21693e-09 (rank : 510)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	747
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.845715 (rank : 354)	θ value	6.21693e-09 (rank : 511)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	747
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

PCTK3_HUMAN
NC score	0.845491 (rank : 355)	θ value	7.84624e-12 (rank : 327)
Query Neighborhood Hits	1407	Target Neighborhood Hits	827	Shared Neighborhood Hits	744
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

RK_HUMAN
NC score	0.845269 (rank : 356)	θ value	9.26847e-13 (rank : 268)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	741
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MAPK2_MOUSE
NC score	0.844700 (rank : 357)	θ value	1.63604e-09 (rank : 469)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	729
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAK_HUMAN
NC score	0.844450 (rank : 358)	θ value	1.133e-10 (rank : 400)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	750
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

CDKL5_HUMAN
NC score	0.844250 (rank : 359)	θ value	3.41135e-07 (rank : 610)
Query Neighborhood Hits	1407	Target Neighborhood Hits	967	Shared Neighborhood Hits	768
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KPCT_MOUSE
NC score	0.844072 (rank : 360)	θ value	1.2105e-12 (rank : 273)
Query Neighborhood Hits	1407	Target Neighborhood Hits	895	Shared Neighborhood Hits	753
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

ERN2_HUMAN
NC score	0.843939 (rank : 361)	θ value	8.11959e-09 (rank : 517)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	737
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KPCT_HUMAN
NC score	0.843809 (rank : 362)	θ value	1.133e-10 (rank : 399)
Query Neighborhood Hits	1407	Target Neighborhood Hits	897	Shared Neighborhood Hits	756
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CD2L5_HUMAN
NC score	0.843645 (rank : 363)	θ value	7.84624e-12 (rank : 318)
Query Neighborhood Hits	1407	Target Neighborhood Hits	987	Shared Neighborhood Hits	777
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
NC score	0.843640 (rank : 364)	θ value	7.84624e-12 (rank : 319)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1011	Shared Neighborhood Hits	785
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDK9_HUMAN
NC score	0.843326 (rank : 365)	θ value	1.06045e-08 (rank : 521)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	743
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
NC score	0.843153 (rank : 366)	θ value	3.64472e-09 (rank : 492)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	743
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

MAPK3_MOUSE
NC score	0.842855 (rank : 367)	θ value	3.89403e-11 (rank : 365)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

PKN2_HUMAN
NC score	0.842219 (rank : 368)	θ value	4.30538e-10 (rank : 442)
Query Neighborhood Hits	1407	Target Neighborhood Hits	892	Shared Neighborhood Hits	745
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MASTL_MOUSE
NC score	0.842206 (rank : 369)	θ value	4.92598e-06 (rank : 655)
Query Neighborhood Hits	1407	Target Neighborhood Hits	862	Shared Neighborhood Hits	746
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PKN2_MOUSE
NC score	0.842084 (rank : 370)	θ value	4.30538e-10 (rank : 443)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	745
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MASTL_HUMAN
NC score	0.841885 (rank : 371)	θ value	1.69304e-06 (rank : 640)
Query Neighborhood Hits	1407	Target Neighborhood Hits	894	Shared Neighborhood Hits	750
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

KS6A5_HUMAN
NC score	0.841619 (rank : 372)	θ value	6.64225e-11 (rank : 385)
Query Neighborhood Hits	1407	Target Neighborhood Hits	855	Shared Neighborhood Hits	752
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

LIMK2_HUMAN
NC score	0.841532 (rank : 373)	θ value	6.41864e-14 (rank : 210)
Query Neighborhood Hits	1407	Target Neighborhood Hits	986	Shared Neighborhood Hits	749
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CDK4_MOUSE
NC score	0.841501 (rank : 374)	θ value	2.69671e-12 (rank : 291)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	747
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

KS6A4_MOUSE
NC score	0.841190 (rank : 375)	θ value	6.00763e-12 (rank : 314)
Query Neighborhood Hits	1407	Target Neighborhood Hits	866	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

CDK4_HUMAN
NC score	0.840589 (rank : 376)	θ value	3.18553e-13 (rank : 240)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MK07_HUMAN
NC score	0.840584 (rank : 377)	θ value	3.08544e-08 (rank : 551)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1087	Shared Neighborhood Hits	883
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

CI096_HUMAN
NC score	0.840186 (rank : 378)	θ value	0.0330416 (rank : 814)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	723
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

KS6A4_HUMAN
NC score	0.840003 (rank : 379)	θ value	8.67504e-11 (rank : 395)
Query Neighborhood Hits	1407	Target Neighborhood Hits	868	Shared Neighborhood Hits	760
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

ERN2_MOUSE
NC score	0.839769 (rank : 380)	θ value	8.40245e-06 (rank : 662)
Query Neighborhood Hits	1407	Target Neighborhood Hits	825	Shared Neighborhood Hits	729
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK07_MOUSE
NC score	0.839574 (rank : 381)	θ value	6.87365e-08 (rank : 569)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1054	Shared Neighborhood Hits	870
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

LIMK2_MOUSE
NC score	0.838797 (rank : 382)	θ value	6.41864e-14 (rank : 211)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	747
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

WEE1_MOUSE
NC score	0.838671 (rank : 383)	θ value	2.88788e-06 (rank : 652)
Query Neighborhood Hits	1407	Target Neighborhood Hits	794	Shared Neighborhood Hits	701
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

PKN1_MOUSE
NC score	0.838661 (rank : 384)	θ value	3.64472e-09 (rank : 497)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	749
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

MAST3_HUMAN
NC score	0.838511 (rank : 385)	θ value	3.89403e-11 (rank : 366)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1128	Shared Neighborhood Hits	846
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAPK3_HUMAN
NC score	0.838453 (rank : 386)	θ value	2.13673e-09 (rank : 478)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	710
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

PKN1_HUMAN
NC score	0.838410 (rank : 387)	θ value	4.76016e-09 (rank : 505)
Query Neighborhood Hits	1407	Target Neighborhood Hits	886	Shared Neighborhood Hits	757
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

CDK10_HUMAN
NC score	0.838132 (rank : 388)	θ value	2.21117e-06 (rank : 642)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	742
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

TTK_HUMAN
NC score	0.837902 (rank : 389)	θ value	θ > 10 (rank : 1624)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	701
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

CCRK_MOUSE
NC score	0.837750 (rank : 390)	θ value	3.64472e-09 (rank : 491)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	743
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

M3KL4_HUMAN
NC score	0.837724 (rank : 391)	θ value	2.20605e-14 (rank : 185)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1087	Shared Neighborhood Hits	779
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PIM2_MOUSE
NC score	0.837439 (rank : 392)	θ value	2.36244e-08 (rank : 545)
Query Neighborhood Hits	1407	Target Neighborhood Hits	809	Shared Neighborhood Hits	726
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

MK12_MOUSE
NC score	0.837324 (rank : 393)	θ value	3.29651e-10 (rank : 431)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CCRK_HUMAN
NC score	0.837160 (rank : 394)	θ value	6.87365e-08 (rank : 564)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	744
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

KGP2_HUMAN
NC score	0.836881 (rank : 395)	θ value	3.41135e-07 (rank : 611)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	761
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KPCI_HUMAN
NC score	0.836736 (rank : 396)	θ value	2.98157e-11 (rank : 351)
Query Neighborhood Hits	1407	Target Neighborhood Hits	885	Shared Neighborhood Hits	751
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

PKN3_HUMAN
NC score	0.836577 (rank : 397)	θ value	9.59137e-10 (rank : 461)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	765
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KPCI_MOUSE
NC score	0.836528 (rank : 398)	θ value	2.98157e-11 (rank : 352)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	751
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

PIM1_HUMAN
NC score	0.836474 (rank : 399)	θ value	6.87365e-08 (rank : 570)
Query Neighborhood Hits	1407	Target Neighborhood Hits	797	Shared Neighborhood Hits	719
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

KGP2_MOUSE
NC score	0.836460 (rank : 400)	θ value	3.41135e-07 (rank : 612)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1029	Shared Neighborhood Hits	757
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KPCE_MOUSE
NC score	0.836403 (rank : 401)	θ value	7.84624e-12 (rank : 322)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MK12_HUMAN
NC score	0.836348 (rank : 402)	θ value	9.59137e-10 (rank : 460)
Query Neighborhood Hits	1407	Target Neighborhood Hits	830	Shared Neighborhood Hits	746
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

KS6A5_MOUSE
NC score	0.836275 (rank : 403)	θ value	1.38499e-08 (rank : 530)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	750
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MKNK2_HUMAN
NC score	0.836140 (rank : 404)	θ value	3.41135e-07 (rank : 614)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	736
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KPCE_HUMAN
NC score	0.835886 (rank : 405)	θ value	1.33837e-11 (rank : 336)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PKN3_MOUSE
NC score	0.835800 (rank : 406)	θ value	3.64472e-09 (rank : 498)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	789
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

MK15_HUMAN
NC score	0.835708 (rank : 407)	θ value	3.64472e-09 (rank : 496)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1038	Shared Neighborhood Hits	806
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK14_HUMAN
NC score	0.835548 (rank : 408)	θ value	5.08577e-11 (rank : 373)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	749
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
NC score	0.835279 (rank : 409)	θ value	1.47974e-10 (rank : 410)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	749
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

LIMK1_HUMAN
NC score	0.835131 (rank : 410)	θ value	2.88119e-14 (rank : 187)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

PIM2_HUMAN
NC score	0.834990 (rank : 411)	θ value	7.59969e-07 (rank : 631)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	731
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

TTK_MOUSE
NC score	0.834797 (rank : 412)	θ value	2.0648e-12 (rank : 290)
Query Neighborhood Hits	1407	Target Neighborhood Hits	803	Shared Neighborhood Hits	691
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

MAST2_MOUSE
NC score	0.834442 (rank : 413)	θ value	2.98157e-11 (rank : 355)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1110	Shared Neighborhood Hits	803
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KGP1A_HUMAN
NC score	0.834279 (rank : 414)	θ value	6.64225e-11 (rank : 381)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	747
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

PIM1_MOUSE
NC score	0.834138 (rank : 415)	θ value	6.87365e-08 (rank : 571)
Query Neighborhood Hits	1407	Target Neighborhood Hits	787	Shared Neighborhood Hits	706
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

LIMK1_MOUSE
NC score	0.834063 (rank : 416)	θ value	2.20605e-14 (rank : 184)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1008	Shared Neighborhood Hits	758
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MKNK2_MOUSE
NC score	0.834058 (rank : 417)	θ value	1.80886e-08 (rank : 536)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	734
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

NLK_MOUSE
NC score	0.833896 (rank : 418)	θ value	4.0297e-08 (rank : 561)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	748
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

KGP1B_MOUSE
NC score	0.833835 (rank : 419)	θ value	6.64225e-11 (rank : 383)
Query Neighborhood Hits	1407	Target Neighborhood Hits	922	Shared Neighborhood Hits	748
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

NLK_HUMAN
NC score	0.833819 (rank : 420)	θ value	4.0297e-08 (rank : 560)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

KGP1B_HUMAN
NC score	0.833792 (rank : 421)	θ value	6.64225e-11 (rank : 382)
Query Neighborhood Hits	1407	Target Neighborhood Hits	921	Shared Neighborhood Hits	748
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

GRK7_HUMAN
NC score	0.833713 (rank : 422)	θ value	4.76016e-09 (rank : 501)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	741
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

MAST2_HUMAN
NC score	0.833582 (rank : 423)	θ value	2.98157e-11 (rank : 354)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1189	Shared Neighborhood Hits	830
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MKNK1_MOUSE
NC score	0.833332 (rank : 424)	θ value	8.11959e-09 (rank : 518)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	720
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MK13_MOUSE
NC score	0.833223 (rank : 425)	θ value	2.98157e-11 (rank : 357)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	745
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

GAK_HUMAN
NC score	0.833020 (rank : 426)	θ value	5.08577e-11 (rank : 372)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1028	Shared Neighborhood Hits	794
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCL_MOUSE
NC score	0.832801 (rank : 427)	θ value	1.25267e-09 (rank : 464)
Query Neighborhood Hits	1407	Target Neighborhood Hits	891	Shared Neighborhood Hits	745
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MK13_HUMAN
NC score	0.832797 (rank : 428)	θ value	3.89403e-11 (rank : 367)
Query Neighborhood Hits	1407	Target Neighborhood Hits	829	Shared Neighborhood Hits	745
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

KPCD_HUMAN
NC score	0.832437 (rank : 429)	θ value	2.13673e-09 (rank : 476)
Query Neighborhood Hits	1407	Target Neighborhood Hits	900	Shared Neighborhood Hits	748
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCZ_HUMAN
NC score	0.832169 (rank : 430)	θ value	6.41864e-14 (rank : 208)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	749
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

CAMKV_MOUSE
NC score	0.832017 (rank : 431)	θ value	3.29651e-10 (rank : 424)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	719
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

KPCZ_MOUSE
NC score	0.831972 (rank : 432)	θ value	8.38298e-14 (rank : 215)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	749
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MAST1_HUMAN
NC score	0.831350 (rank : 433)	θ value	2.98157e-11 (rank : 353)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1146	Shared Neighborhood Hits	830
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PIM3_HUMAN
NC score	0.831016 (rank : 434)	θ value	1.69304e-06 (rank : 641)
Query Neighborhood Hits	1407	Target Neighborhood Hits	789	Shared Neighborhood Hits	719
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

MK03_HUMAN
NC score	0.830861 (rank : 435)	θ value	4.76016e-09 (rank : 504)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	748
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MAST1_MOUSE
NC score	0.830846 (rank : 436)	θ value	2.28291e-11 (rank : 347)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	820
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MK03_MOUSE
NC score	0.830056 (rank : 437)	θ value	1.38499e-08 (rank : 531)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	748
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MAST4_HUMAN
NC score	0.830025 (rank : 438)	θ value	2.98157e-11 (rank : 356)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1804	Shared Neighborhood Hits	979
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

CAMKV_HUMAN
NC score	0.829632 (rank : 439)	θ value	3.29651e-10 (rank : 423)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1084	Shared Neighborhood Hits	788
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

AL2S2_HUMAN
NC score	0.829381 (rank : 440)	θ value	1.29631e-06 (rank : 636)
Query Neighborhood Hits	1407	Target Neighborhood Hits	727	Shared Neighborhood Hits	668
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

MK04_HUMAN
NC score	0.829331 (rank : 441)	θ value	4.0297e-08 (rank : 559)
Query Neighborhood Hits	1407	Target Neighborhood Hits	837	Shared Neighborhood Hits	740
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

KPCD_MOUSE
NC score	0.829217 (rank : 442)	θ value	4.76016e-09 (rank : 502)
Query Neighborhood Hits	1407	Target Neighborhood Hits	888	Shared Neighborhood Hits	744
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MK11_MOUSE
NC score	0.829184 (rank : 443)	θ value	1.63604e-09 (rank : 470)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	747
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

KPCL_HUMAN
NC score	0.829025 (rank : 444)	θ value	1.25267e-09 (rank : 463)
Query Neighborhood Hits	1407	Target Neighborhood Hits	887	Shared Neighborhood Hits	745
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MK15_MOUSE
NC score	0.828480 (rank : 445)	θ value	2.13673e-09 (rank : 479)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	750
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

ARBK1_HUMAN
NC score	0.828099 (rank : 446)	θ value	2.79066e-09 (rank : 483)
Query Neighborhood Hits	1407	Target Neighborhood Hits	859	Shared Neighborhood Hits	741
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

CD2L6_MOUSE
NC score	0.827886 (rank : 447)	θ value	3.29651e-10 (rank : 426)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	733
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.827854 (rank : 448)	θ value	3.29651e-10 (rank : 425)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	738
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

PIM3_MOUSE
NC score	0.827591 (rank : 449)	θ value	1.09739e-05 (rank : 664)
Query Neighborhood Hits	1407	Target Neighborhood Hits	783	Shared Neighborhood Hits	712
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

GSK3A_HUMAN
NC score	0.827282 (rank : 450)	θ value	1.06045e-08 (rank : 525)
Query Neighborhood Hits	1407	Target Neighborhood Hits	835	Shared Neighborhood Hits	735
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

MK04_MOUSE
NC score	0.826973 (rank : 451)	θ value	2.36244e-08 (rank : 543)
Query Neighborhood Hits	1407	Target Neighborhood Hits	852	Shared Neighborhood Hits	741
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

ARBK2_HUMAN
NC score	0.826652 (rank : 452)	θ value	5.62301e-10 (rank : 444)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	737
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARBK1_MOUSE
NC score	0.826606 (rank : 453)	θ value	2.13673e-09 (rank : 472)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	740
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

GAK_MOUSE
NC score	0.826520 (rank : 454)	θ value	4.59992e-12 (rank : 308)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	767
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

RIPK2_HUMAN
NC score	0.825814 (rank : 455)	θ value	6.00763e-12 (rank : 317)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

F5006_MOUSE
NC score	0.825783 (rank : 456)	θ value	0.000270298 (rank : 712)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	716
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

STK10_MOUSE
NC score	0.825311 (rank : 457)	θ value	1.80466e-16 (rank : 122)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2132	Shared Neighborhood Hits	858
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CD2L2_HUMAN
NC score	0.823848 (rank : 458)	θ value	1.53129e-07 (rank : 586)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1439	Shared Neighborhood Hits	791
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

WEE1_HUMAN
NC score	0.823478 (rank : 459)	θ value	7.1131e-05 (rank : 695)
Query Neighborhood Hits	1407	Target Neighborhood Hits	777	Shared Neighborhood Hits	682
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

CDK8_HUMAN
NC score	0.823099 (rank : 460)	θ value	3.29651e-10 (rank : 427)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	734
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

MK11_HUMAN
NC score	0.822858 (rank : 461)	θ value	3.08544e-08 (rank : 552)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	741
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

RIPK2_MOUSE
NC score	0.822727 (rank : 462)	θ value	2.69671e-12 (rank : 294)
Query Neighborhood Hits	1407	Target Neighborhood Hits	776	Shared Neighborhood Hits	707
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

GSK3B_MOUSE
NC score	0.822695 (rank : 463)	θ value	8.97725e-08 (rank : 577)
Query Neighborhood Hits	1407	Target Neighborhood Hits	800	Shared Neighborhood Hits	720
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_HUMAN
NC score	0.822693 (rank : 464)	θ value	8.97725e-08 (rank : 576)
Query Neighborhood Hits	1407	Target Neighborhood Hits	801	Shared Neighborhood Hits	720
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

BMP2K_HUMAN
NC score	0.822004 (rank : 465)	θ value	4.1701e-05 (rank : 680)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	724
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

KSR1_MOUSE
NC score	0.821974 (rank : 466)	θ value	1.53129e-07 (rank : 587)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	745
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

BMP2K_MOUSE
NC score	0.821759 (rank : 467)	θ value	0.00020696 (rank : 707)
Query Neighborhood Hits	1407	Target Neighborhood Hits	874	Shared Neighborhood Hits	721
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

MK09_HUMAN
NC score	0.821147 (rank : 468)	θ value	2.21117e-06 (rank : 644)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	748
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

CD2L1_HUMAN
NC score	0.821032 (rank : 469)	θ value	2.61198e-07 (rank : 601)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1467	Shared Neighborhood Hits	790
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

AAK1_HUMAN
NC score	0.820792 (rank : 470)	θ value	0.00869519 (rank : 779)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1077	Shared Neighborhood Hits	847
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
NC score	0.820752 (rank : 471)	θ value	0.00665767 (rank : 771)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1051	Shared Neighborhood Hits	826
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CD2L1_MOUSE
NC score	0.820461 (rank : 472)	θ value	4.45536e-07 (rank : 617)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1463	Shared Neighborhood Hits	790
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

KPCA_MOUSE
NC score	0.819463 (rank : 473)	θ value	5.62301e-10 (rank : 450)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1067	Shared Neighborhood Hits	748
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MK09_MOUSE
NC score	0.818872 (rank : 474)	θ value	7.59969e-07 (rank : 629)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	747
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CSKP_MOUSE
NC score	0.818853 (rank : 475)	θ value	7.09661e-13 (rank : 254)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1027	Shared Neighborhood Hits	740
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

WEE1B_HUMAN
NC score	0.818805 (rank : 476)	θ value	4.1701e-05 (rank : 682)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	696
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

AL2S2_MOUSE
NC score	0.818777 (rank : 477)	θ value	2.88788e-06 (rank : 648)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	651
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

KPCA_HUMAN
NC score	0.818028 (rank : 478)	θ value	1.47974e-10 (rank : 408)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1070	Shared Neighborhood Hits	751
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

GRK4_HUMAN
NC score	0.817777 (rank : 479)	θ value	1.69304e-06 (rank : 639)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	734
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

F5006_HUMAN
NC score	0.817623 (rank : 480)	θ value	0.000270298 (rank : 711)
Query Neighborhood Hits	1407	Target Neighborhood Hits	794	Shared Neighborhood Hits	714
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MK10_HUMAN
NC score	0.817388 (rank : 481)	θ value	2.44474e-05 (rank : 672)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
NC score	0.817325 (rank : 482)	θ value	2.44474e-05 (rank : 673)
Query Neighborhood Hits	1407	Target Neighborhood Hits	849	Shared Neighborhood Hits	747
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

CSKP_HUMAN
NC score	0.816204 (rank : 483)	θ value	2.0648e-12 (rank : 284)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1022	Shared Neighborhood Hits	738
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

MK01_HUMAN
NC score	0.816111 (rank : 484)	θ value	θ > 10 (rank : 1519)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
NC score	0.816024 (rank : 485)	θ value	θ > 10 (rank : 1520)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK08_MOUSE
NC score	0.815862 (rank : 486)	θ value	5.44631e-05 (rank : 686)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK08_HUMAN
NC score	0.815178 (rank : 487)	θ value	5.44631e-05 (rank : 685)
Query Neighborhood Hits	1407	Target Neighborhood Hits	834	Shared Neighborhood Hits	745
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

JAK2_HUMAN
NC score	0.814469 (rank : 488)	θ value	3.07829e-16 (rank : 128)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	748
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

WEE1B_MOUSE
NC score	0.814413 (rank : 489)	θ value	2.21117e-06 (rank : 646)
Query Neighborhood Hits	1407	Target Neighborhood Hits	765	Shared Neighborhood Hits	690
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

KSR1_HUMAN
NC score	0.814124 (rank : 490)	θ value	1.17247e-07 (rank : 582)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	730
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MK06_HUMAN
NC score	0.813747 (rank : 491)	θ value	2.61198e-07 (rank : 604)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	716
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.813413 (rank : 492)	θ value	2.61198e-07 (rank : 605)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

GRK6_HUMAN
NC score	0.812634 (rank : 493)	θ value	θ > 10 (rank : 1481)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	737
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

JAK2_MOUSE
NC score	0.812622 (rank : 494)	θ value	3.07829e-16 (rank : 129)
Query Neighborhood Hits	1407	Target Neighborhood Hits	839	Shared Neighborhood Hits	744
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

GRK6_MOUSE
NC score	0.812420 (rank : 495)	θ value	θ > 10 (rank : 1482)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	738
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

DMPK_MOUSE
NC score	0.811793 (rank : 496)	θ value	7.1131e-05 (rank : 688)
Query Neighborhood Hits	1407	Target Neighborhood Hits	908	Shared Neighborhood Hits	740
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ST38L_HUMAN
NC score	0.811670 (rank : 497)	θ value	2.79066e-09 (rank : 487)
Query Neighborhood Hits	1407	Target Neighborhood Hits	824	Shared Neighborhood Hits	718
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

DMPK_HUMAN
NC score	0.811155 (rank : 498)	θ value	3.19293e-05 (rank : 676)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	739
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

STK38_MOUSE
NC score	0.810662 (rank : 499)	θ value	2.61198e-07 (rank : 607)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	723
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.810269 (rank : 500)	θ value	2.61198e-07 (rank : 606)
Query Neighborhood Hits	1407	Target Neighborhood Hits	840	Shared Neighborhood Hits	723
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KPCG_MOUSE
NC score	0.809439 (rank : 501)	θ value	6.64225e-11 (rank : 384)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1123	Shared Neighborhood Hits	750
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

GRK5_MOUSE
NC score	0.809155 (rank : 502)	θ value	θ > 10 (rank : 1480)
Query Neighborhood Hits	1407	Target Neighborhood Hits	823	Shared Neighborhood Hits	732
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

IRAK1_HUMAN
NC score	0.809029 (rank : 503)	θ value	5.26297e-08 (rank : 562)
Query Neighborhood Hits	1407	Target Neighborhood Hits	820	Shared Neighborhood Hits	723
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

KPCB_MOUSE
NC score	0.808792 (rank : 504)	θ value	4.30538e-10 (rank : 440)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1117	Shared Neighborhood Hits	753
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

GRK5_HUMAN
NC score	0.808689 (rank : 505)	θ value	θ > 10 (rank : 1479)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	732
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCG_HUMAN
NC score	0.808521 (rank : 506)	θ value	1.47974e-10 (rank : 409)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1126	Shared Neighborhood Hits	750
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_HUMAN
NC score	0.807945 (rank : 507)	θ value	4.30538e-10 (rank : 439)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1121	Shared Neighborhood Hits	753
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MAPK5_MOUSE
NC score	0.807122 (rank : 508)	θ value	θ > 10 (rank : 1511)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

IRAK1_MOUSE
NC score	0.806936 (rank : 509)	θ value	6.21693e-09 (rank : 509)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	706
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

MOK_HUMAN
NC score	0.806935 (rank : 510)	θ value	1.43324e-05 (rank : 665)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	718
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MYLK_HUMAN
NC score	0.806228 (rank : 511)	θ value	7.82807e-20 (rank : 42)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1328	Shared Neighborhood Hits	777
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
NC score	0.806154 (rank : 512)	θ value	1.02238e-19 (rank : 47)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1489	Shared Neighborhood Hits	828
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MAPK5_HUMAN
NC score	0.806099 (rank : 513)	θ value	θ > 10 (rank : 1510)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	715
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MOK_MOUSE
NC score	0.803222 (rank : 514)	θ value	3.19293e-05 (rank : 678)
Query Neighborhood Hits	1407	Target Neighborhood Hits	796	Shared Neighborhood Hits	714
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

ST38L_MOUSE
NC score	0.802666 (rank : 515)	θ value	2.79066e-09 (rank : 488)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	712
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TYK2_HUMAN
NC score	0.802417 (rank : 516)	θ value	3.29651e-10 (rank : 435)
Query Neighborhood Hits	1407	Target Neighborhood Hits	841	Shared Neighborhood Hits	745
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

GRK4_MOUSE
NC score	0.802241 (rank : 517)	θ value	θ > 10 (rank : 1478)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	727
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

SPEG_HUMAN
NC score	0.798786 (rank : 518)	θ value	1.33837e-11 (rank : 341)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1762	Shared Neighborhood Hits	979
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CSK21_MOUSE
NC score	0.797607 (rank : 519)	θ value	5.81887e-07 (rank : 621)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	693
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_HUMAN
NC score	0.796579 (rank : 520)	θ value	5.81887e-07 (rank : 620)
Query Neighborhood Hits	1407	Target Neighborhood Hits	772	Shared Neighborhood Hits	693
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

HIPK4_HUMAN
NC score	0.795497 (rank : 521)	θ value	0.000121331 (rank : 700)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	716
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

LATS1_HUMAN
NC score	0.795425 (rank : 522)	θ value	0.00102713 (rank : 727)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1057	Shared Neighborhood Hits	821
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

TYK2_MOUSE
NC score	0.794212 (rank : 523)	θ value	θ > 10 (rank : 1625)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	745
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

SPEG_MOUSE
NC score	0.794083 (rank : 524)	θ value	1.02475e-11 (rank : 334)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1022
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DAPK1_HUMAN
NC score	0.793888 (rank : 525)	θ value	2.35696e-16 (rank : 123)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1130	Shared Neighborhood Hits	757
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

JAK3_HUMAN
NC score	0.793796 (rank : 526)	θ value	8.38298e-14 (rank : 214)
Query Neighborhood Hits	1407	Target Neighborhood Hits	827	Shared Neighborhood Hits	746
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

LATS1_MOUSE
NC score	0.793713 (rank : 527)	θ value	0.00134147 (rank : 731)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1027	Shared Neighborhood Hits	806
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

JAK1_HUMAN
NC score	0.792467 (rank : 528)	θ value	5.62301e-10 (rank : 449)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	745
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

DAPK1_MOUSE
NC score	0.790211 (rank : 529)	θ value	6.85773e-16 (rank : 143)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1138	Shared Neighborhood Hits	756
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

LATS2_HUMAN
NC score	0.789345 (rank : 530)	θ value	4.1701e-05 (rank : 681)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	760
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

CSK22_MOUSE
NC score	0.789243 (rank : 531)	θ value	7.59969e-07 (rank : 626)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	683
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

MRCKG_HUMAN
NC score	0.789166 (rank : 532)	θ value	6.21693e-09 (rank : 512)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1519	Shared Neighborhood Hits	789
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

CSK22_HUMAN
NC score	0.788424 (rank : 533)	θ value	9.92553e-07 (rank : 632)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	683
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DUET_HUMAN
NC score	0.788292 (rank : 534)	θ value	9.26847e-13 (rank : 260)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1220	Shared Neighborhood Hits	758
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FES_MOUSE
NC score	0.787667 (rank : 535)	θ value	2.36244e-08 (rank : 541)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	756
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.787342 (rank : 536)	θ value	3.08544e-08 (rank : 549)
Query Neighborhood Hits	1407	Target Neighborhood Hits	978	Shared Neighborhood Hits	749
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

JAK1_MOUSE
NC score	0.787331 (rank : 537)	θ value	9.59137e-10 (rank : 458)
Query Neighborhood Hits	1407	Target Neighborhood Hits	854	Shared Neighborhood Hits	744
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK3_MOUSE
NC score	0.787084 (rank : 538)	θ value	θ > 10 (rank : 1494)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	738
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

LATS2_MOUSE
NC score	0.786721 (rank : 539)	θ value	0.00035302 (rank : 718)
Query Neighborhood Hits	1407	Target Neighborhood Hits	879	Shared Neighborhood Hits	749
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MYO3A_MOUSE
NC score	0.785604 (rank : 540)	θ value	7.32683e-18 (rank : 79)
Query Neighborhood Hits	1407	Target Neighborhood Hits	902	Shared Neighborhood Hits	745
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MRCKG_MOUSE
NC score	0.785007 (rank : 541)	θ value	1.38499e-08 (rank : 532)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1466	Shared Neighborhood Hits	769
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

STK40_HUMAN
NC score	0.783454 (rank : 542)	θ value	0.00509761 (rank : 769)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
NC score	0.782986 (rank : 543)	θ value	0.00509761 (rank : 770)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	675
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

PTK6_HUMAN
NC score	0.782587 (rank : 544)	θ value	5.43371e-13 (rank : 252)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	757
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TRIO_HUMAN
NC score	0.780720 (rank : 545)	θ value	5.62301e-10 (rank : 452)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1580	Shared Neighborhood Hits	814
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DYR1B_MOUSE
NC score	0.780020 (rank : 546)	θ value	6.64225e-11 (rank : 380)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	711
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

PTK6_MOUSE
NC score	0.779682 (rank : 547)	θ value	2.98157e-11 (rank : 358)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	757
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

FAK1_HUMAN
NC score	0.779463 (rank : 548)	θ value	4.30538e-10 (rank : 437)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	751
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

BMX_HUMAN
NC score	0.779360 (rank : 549)	θ value	1.86753e-13 (rank : 227)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	736
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

MYO3A_HUMAN
NC score	0.779040 (rank : 550)	θ value	2.13179e-17 (rank : 90)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1033	Shared Neighborhood Hits	757
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

BMX_MOUSE
NC score	0.778837 (rank : 551)	θ value	6.41864e-14 (rank : 204)
Query Neighborhood Hits	1407	Target Neighborhood Hits	912	Shared Neighborhood Hits	733
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

FAK1_MOUSE
NC score	0.778599 (rank : 552)	θ value	6.87365e-08 (rank : 567)
Query Neighborhood Hits	1407	Target Neighborhood Hits	850	Shared Neighborhood Hits	747
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

TEC_MOUSE
NC score	0.778436 (rank : 553)	θ value	6.64225e-11 (rank : 391)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1006	Shared Neighborhood Hits	745
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DYR1B_HUMAN
NC score	0.778340 (rank : 554)	θ value	1.9326e-10 (rank : 414)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	723
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

AVR2A_MOUSE
NC score	0.776761 (rank : 555)	θ value	8.11959e-09 (rank : 515)
Query Neighborhood Hits	1407	Target Neighborhood Hits	767	Shared Neighborhood Hits	710
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.776748 (rank : 556)	θ value	8.11959e-09 (rank : 514)
Query Neighborhood Hits	1407	Target Neighborhood Hits	767	Shared Neighborhood Hits	710
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

TGFR2_MOUSE
NC score	0.776129 (rank : 557)	θ value	2.13673e-09 (rank : 482)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	695
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TXK_HUMAN
NC score	0.776076 (rank : 558)	θ value	3.89403e-11 (rank : 369)
Query Neighborhood Hits	1407	Target Neighborhood Hits	971	Shared Neighborhood Hits	741
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ITK_MOUSE
NC score	0.775688 (rank : 559)	θ value	1.42992e-13 (rank : 219)
Query Neighborhood Hits	1407	Target Neighborhood Hits	985	Shared Neighborhood Hits	749
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TGFR2_HUMAN
NC score	0.775235 (rank : 560)	θ value	1.63604e-09 (rank : 471)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	694
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ITK_HUMAN
NC score	0.775005 (rank : 561)	θ value	1.86753e-13 (rank : 228)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1016	Shared Neighborhood Hits	751
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TEC_HUMAN
NC score	0.774889 (rank : 562)	θ value	1.133e-10 (rank : 401)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1006	Shared Neighborhood Hits	747
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MKNK1_HUMAN
NC score	0.774174 (rank : 563)	θ value	1.87187e-05 (rank : 668)
Query Neighborhood Hits	1407	Target Neighborhood Hits	701	Shared Neighborhood Hits	629
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

ABL1_MOUSE
NC score	0.773880 (rank : 564)	θ value	1.133e-10 (rank : 398)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1178	Shared Neighborhood Hits	830
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK_MOUSE
NC score	0.773300 (rank : 565)	θ value	2.21117e-06 (rank : 643)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	754
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

FER_HUMAN
NC score	0.773291 (rank : 566)	θ value	3.52202e-12 (rank : 302)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1278	Shared Neighborhood Hits	753
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

OBSCN_HUMAN
NC score	0.772422 (rank : 567)	θ value	7.84624e-12 (rank : 324)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1931	Shared Neighborhood Hits	922
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MYO3B_HUMAN
NC score	0.772144 (rank : 568)	θ value	1.42992e-13 (rank : 223)
Query Neighborhood Hits	1407	Target Neighborhood Hits	923	Shared Neighborhood Hits	754
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

LRRK1_MOUSE
NC score	0.771872 (rank : 569)	θ value	2.88119e-14 (rank : 188)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1267	Shared Neighborhood Hits	740
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ABL1_HUMAN
NC score	0.771806 (rank : 570)	θ value	1.133e-10 (rank : 397)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1220	Shared Neighborhood Hits	827
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

LRRK1_HUMAN
NC score	0.771183 (rank : 571)	θ value	1.2105e-12 (rank : 274)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1237	Shared Neighborhood Hits	734
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ZAP70_HUMAN
NC score	0.770147 (rank : 572)	θ value	5.81887e-07 (rank : 625)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	743
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FRK_HUMAN
NC score	0.769511 (rank : 573)	θ value	2.28291e-11 (rank : 346)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	767
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

TXK_MOUSE
NC score	0.769341 (rank : 574)	θ value	6.64225e-11 (rank : 392)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	743
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

DYRK2_HUMAN
NC score	0.769299 (rank : 575)	θ value	θ > 10 (rank : 1459)
Query Neighborhood Hits	1407	Target Neighborhood Hits	799	Shared Neighborhood Hits	707
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

LYN_MOUSE
NC score	0.768884 (rank : 576)	θ value	6.00763e-12 (rank : 315)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	767
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FAK2_MOUSE
NC score	0.768867 (rank : 577)	θ value	2.98157e-11 (rank : 348)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	738
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LYN_HUMAN
NC score	0.768575 (rank : 578)	θ value	1.33837e-11 (rank : 338)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1022	Shared Neighborhood Hits	765
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MLKL_MOUSE
NC score	0.767021 (rank : 579)	θ value	4.45536e-07 (rank : 618)
Query Neighborhood Hits	1407	Target Neighborhood Hits	707	Shared Neighborhood Hits	651
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ABL2_HUMAN
NC score	0.766901 (rank : 580)	θ value	4.76016e-09 (rank : 499)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1045	Shared Neighborhood Hits	762
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SRMS_MOUSE
NC score	0.766814 (rank : 581)	θ value	8.67504e-11 (rank : 396)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	755
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ZAP70_MOUSE
NC score	0.766786 (rank : 582)	θ value	1.29631e-06 (rank : 638)
Query Neighborhood Hits	1407	Target Neighborhood Hits	905	Shared Neighborhood Hits	748
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MATK_MOUSE
NC score	0.766274 (rank : 583)	θ value	2.61198e-07 (rank : 603)
Query Neighborhood Hits	1407	Target Neighborhood Hits	952	Shared Neighborhood Hits	752
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

KSYK_MOUSE
NC score	0.766266 (rank : 584)	θ value	6.64225e-11 (rank : 386)
Query Neighborhood Hits	1407	Target Neighborhood Hits	944	Shared Neighborhood Hits	755
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CSK_HUMAN
NC score	0.766107 (rank : 585)	θ value	8.40245e-06 (rank : 661)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	754
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DYR1A_MOUSE
NC score	0.766029 (rank : 586)	θ value	1.80886e-08 (rank : 534)
Query Neighborhood Hits	1407	Target Neighborhood Hits	762	Shared Neighborhood Hits	687
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.766020 (rank : 587)	θ value	1.80886e-08 (rank : 533)
Query Neighborhood Hits	1407	Target Neighborhood Hits	764	Shared Neighborhood Hits	687
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

BTK_HUMAN
NC score	0.765647 (rank : 588)	θ value	5.08577e-11 (rank : 370)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	746
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ACVR1_MOUSE
NC score	0.765530 (rank : 589)	θ value	3.41135e-07 (rank : 609)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	712
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

BTK_MOUSE
NC score	0.765486 (rank : 590)	θ value	1.47974e-10 (rank : 403)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1017	Shared Neighborhood Hits	746
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

KSYK_HUMAN
NC score	0.765474 (rank : 591)	θ value	2.13673e-09 (rank : 477)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	743
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FAK2_HUMAN
NC score	0.765287 (rank : 592)	θ value	8.67504e-11 (rank : 394)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	737
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LRRK2_HUMAN
NC score	0.764603 (rank : 593)	θ value	1.33837e-11 (rank : 337)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1382	Shared Neighborhood Hits	748
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

DYRK3_HUMAN
NC score	0.764306 (rank : 594)	θ value	θ > 10 (rank : 1460)
Query Neighborhood Hits	1407	Target Neighborhood Hits	798	Shared Neighborhood Hits	710
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

LCK_MOUSE
NC score	0.763380 (rank : 595)	θ value	3.89403e-11 (rank : 363)
Query Neighborhood Hits	1407	Target Neighborhood Hits	981	Shared Neighborhood Hits	756
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

UHMK1_HUMAN
NC score	0.763333 (rank : 596)	θ value	0.00665767 (rank : 777)
Query Neighborhood Hits	1407	Target Neighborhood Hits	808	Shared Neighborhood Hits	690
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ACVR1_HUMAN
NC score	0.763236 (rank : 597)	θ value	4.0297e-08 (rank : 556)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	706
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

AVR2B_MOUSE
NC score	0.763218 (rank : 598)	θ value	2.36244e-08 (rank : 539)
Query Neighborhood Hits	1407	Target Neighborhood Hits	749	Shared Neighborhood Hits	695
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.762984 (rank : 599)	θ value	2.36244e-08 (rank : 538)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	695
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

UHMK1_MOUSE
NC score	0.762861 (rank : 600)	θ value	0.00665767 (rank : 778)
Query Neighborhood Hits	1407	Target Neighborhood Hits	809	Shared Neighborhood Hits	690
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MATK_HUMAN
NC score	0.762799 (rank : 601)	θ value	3.77169e-06 (rank : 654)
Query Neighborhood Hits	1407	Target Neighborhood Hits	954	Shared Neighborhood Hits	751
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SRMS_HUMAN
NC score	0.761040 (rank : 602)	θ value	9.59137e-10 (rank : 462)
Query Neighborhood Hits	1407	Target Neighborhood Hits	946	Shared Neighborhood Hits	755
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BLK_HUMAN
NC score	0.758915 (rank : 603)	θ value	6.64225e-11 (rank : 377)
Query Neighborhood Hits	1407	Target Neighborhood Hits	994	Shared Neighborhood Hits	758
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LCK_HUMAN
NC score	0.757266 (rank : 604)	θ value	1.9326e-10 (rank : 416)
Query Neighborhood Hits	1407	Target Neighborhood Hits	987	Shared Neighborhood Hits	759
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

HIPK3_MOUSE
NC score	0.756854 (rank : 605)	θ value	0.00869519 (rank : 781)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	731
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

BLK_MOUSE
NC score	0.755431 (rank : 606)	θ value	5.62301e-10 (rank : 445)
Query Neighborhood Hits	1407	Target Neighborhood Hits	992	Shared Neighborhood Hits	759
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HIPK3_HUMAN
NC score	0.755054 (rank : 607)	θ value	0.00869519 (rank : 780)
Query Neighborhood Hits	1407	Target Neighborhood Hits	867	Shared Neighborhood Hits	727
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

TNK1_MOUSE
NC score	0.754872 (rank : 608)	θ value	9.29e-05 (rank : 698)
Query Neighborhood Hits	1407	Target Neighborhood Hits	806	Shared Neighborhood Hits	728
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

HIPK1_HUMAN
NC score	0.753783 (rank : 609)	θ value	0.00390308 (rank : 756)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	722
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

BMR1A_HUMAN
NC score	0.753681 (rank : 610)	θ value	3.08544e-08 (rank : 546)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	698
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

HIPK1_MOUSE
NC score	0.753460 (rank : 611)	θ value	0.00390308 (rank : 757)
Query Neighborhood Hits	1407	Target Neighborhood Hits	838	Shared Neighborhood Hits	720
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

TNI3K_MOUSE
NC score	0.753049 (rank : 612)	θ value	5.43371e-13 (rank : 253)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1079	Shared Neighborhood Hits	736
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

BMR1A_MOUSE
NC score	0.752699 (rank : 613)	θ value	3.08544e-08 (rank : 547)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	699
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

HCK_MOUSE
NC score	0.752639 (rank : 614)	θ value	4.30538e-10 (rank : 438)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1029	Shared Neighborhood Hits	762
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ERBB4_HUMAN
NC score	0.751417 (rank : 615)	θ value	2.43908e-13 (rank : 234)
Query Neighborhood Hits	1407	Target Neighborhood Hits	910	Shared Neighborhood Hits	745
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

HCK_HUMAN
NC score	0.751226 (rank : 616)	θ value	3.89403e-11 (rank : 361)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1035	Shared Neighborhood Hits	763
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FYN_HUMAN
NC score	0.751079 (rank : 617)	θ value	3.29651e-10 (rank : 428)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1078	Shared Neighborhood Hits	763
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.751000 (rank : 618)	θ value	7.09661e-13 (rank : 258)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	755
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.750144 (rank : 619)	θ value	3.29651e-10 (rank : 429)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1073	Shared Neighborhood Hits	763
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TNK1_HUMAN
NC score	0.749859 (rank : 620)	θ value	2.88788e-06 (rank : 651)
Query Neighborhood Hits	1407	Target Neighborhood Hits	815	Shared Neighborhood Hits	740
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

LRRK2_MOUSE
NC score	0.749696 (rank : 621)	θ value	6.64225e-11 (rank : 387)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1359	Shared Neighborhood Hits	746
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

PRP4B_HUMAN
NC score	0.749371 (rank : 622)	θ value	0.0113563 (rank : 788)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1030	Shared Neighborhood Hits	726
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

HIPK2_HUMAN
NC score	0.749318 (rank : 623)	θ value	0.00390308 (rank : 758)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	721
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.749027 (rank : 624)	θ value	0.00390308 (rank : 759)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	725
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

SRC_MOUSE
NC score	0.748501 (rank : 625)	θ value	1.2105e-12 (rank : 278)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1033	Shared Neighborhood Hits	754
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ACK1_HUMAN
NC score	0.748303 (rank : 626)	θ value	0.00020696 (rank : 705)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1140	Shared Neighborhood Hits	876
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TGFR1_HUMAN
NC score	0.748202 (rank : 627)	θ value	1.17247e-07 (rank : 583)
Query Neighborhood Hits	1407	Target Neighborhood Hits	755	Shared Neighborhood Hits	703
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TNI3K_HUMAN
NC score	0.748050 (rank : 628)	θ value	1.86753e-13 (rank : 233)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1084	Shared Neighborhood Hits	742
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

EGFR_MOUSE
NC score	0.747956 (rank : 629)	θ value	9.26847e-13 (rank : 262)
Query Neighborhood Hits	1407	Target Neighborhood Hits	927	Shared Neighborhood Hits	741
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

TGFR1_MOUSE
NC score	0.747670 (rank : 630)	θ value	1.17247e-07 (rank : 584)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	703
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

EGFR_HUMAN
NC score	0.747448 (rank : 631)	θ value	9.26847e-13 (rank : 261)
Query Neighborhood Hits	1407	Target Neighborhood Hits	939	Shared Neighborhood Hits	739
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

PRP4B_MOUSE
NC score	0.747394 (rank : 632)	θ value	0.0113563 (rank : 789)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1040	Shared Neighborhood Hits	723
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

EPHA5_MOUSE
NC score	0.747084 (rank : 633)	θ value	1.06045e-08 (rank : 522)
Query Neighborhood Hits	1407	Target Neighborhood Hits	950	Shared Neighborhood Hits	754
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ACK1_MOUSE
NC score	0.746671 (rank : 634)	θ value	4.1701e-05 (rank : 679)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1080	Shared Neighborhood Hits	853
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

YES_HUMAN
NC score	0.746340 (rank : 635)	θ value	1.33837e-11 (rank : 342)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1059	Shared Neighborhood Hits	756
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.745870 (rank : 636)	θ value	1.33837e-11 (rank : 343)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1052	Shared Neighborhood Hits	754
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BMR1B_MOUSE
NC score	0.744324 (rank : 637)	θ value	1.17247e-07 (rank : 581)
Query Neighborhood Hits	1407	Target Neighborhood Hits	758	Shared Neighborhood Hits	696
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.743687 (rank : 638)	θ value	1.17247e-07 (rank : 580)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	696
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

EPHB1_HUMAN
NC score	0.743346 (rank : 639)	θ value	2.0648e-12 (rank : 285)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	751
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TOPK_MOUSE
NC score	0.742768 (rank : 640)	θ value	3.29651e-10 (rank : 434)
Query Neighborhood Hits	1407	Target Neighborhood Hits	618	Shared Neighborhood Hits	563
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

BMPR2_HUMAN
NC score	0.742735 (rank : 641)	θ value	2.79066e-09 (rank : 484)
Query Neighborhood Hits	1407	Target Neighborhood Hits	736	Shared Neighborhood Hits	663
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

ACV1B_MOUSE
NC score	0.742445 (rank : 642)	θ value	1.99992e-07 (rank : 591)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	706
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

BMPR2_MOUSE
NC score	0.742414 (rank : 643)	θ value	1.63604e-09 (rank : 465)
Query Neighborhood Hits	1407	Target Neighborhood Hits	738	Shared Neighborhood Hits	665
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ACV1B_HUMAN
NC score	0.742367 (rank : 644)	θ value	1.99992e-07 (rank : 590)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	707
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

DYRK4_HUMAN
NC score	0.742133 (rank : 645)	θ value	θ > 10 (rank : 1461)
Query Neighborhood Hits	1407	Target Neighborhood Hits	750	Shared Neighborhood Hits	675
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

TRIB2_HUMAN
NC score	0.739686 (rank : 646)	θ value	0.00869519 (rank : 784)
Query Neighborhood Hits	1407	Target Neighborhood Hits	657	Shared Neighborhood Hits	608
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.739288 (rank : 647)	θ value	0.00869519 (rank : 785)
Query Neighborhood Hits	1407	Target Neighborhood Hits	653	Shared Neighborhood Hits	604
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TOPK_HUMAN
NC score	0.739155 (rank : 648)	θ value	1.133e-10 (rank : 402)
Query Neighborhood Hits	1407	Target Neighborhood Hits	605	Shared Neighborhood Hits	549
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

MRCKA_HUMAN
NC score	0.737626 (rank : 649)	θ value	8.11959e-09 (rank : 519)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1999	Shared Neighborhood Hits	800
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CTRO_HUMAN
NC score	0.735643 (rank : 650)	θ value	4.0297e-08 (rank : 557)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2092	Shared Neighborhood Hits	819
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

RET_HUMAN
NC score	0.735528 (rank : 651)	θ value	0.000461057 (rank : 723)
Query Neighborhood Hits	1407	Target Neighborhood Hits	873	Shared Neighborhood Hits	744
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
NC score	0.735126 (rank : 652)	θ value	0.000270298 (rank : 715)
Query Neighborhood Hits	1407	Target Neighborhood Hits	884	Shared Neighborhood Hits	741
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ERBB2_MOUSE
NC score	0.734571 (rank : 653)	θ value	1.63604e-09 (rank : 467)
Query Neighborhood Hits	1407	Target Neighborhood Hits	918	Shared Neighborhood Hits	752
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EPHA3_HUMAN
NC score	0.734172 (rank : 654)	θ value	4.30538e-10 (rank : 436)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1005	Shared Neighborhood Hits	763
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

PINK1_MOUSE
NC score	0.734058 (rank : 655)	θ value	3.0926 (rank : 1152)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	668
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

FGR_HUMAN
NC score	0.733852 (rank : 656)	θ value	1.06045e-08 (rank : 524)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1067	Shared Neighborhood Hits	762
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ROCK2_HUMAN
NC score	0.733546 (rank : 657)	θ value	9.92553e-07 (rank : 634)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2073	Shared Neighborhood Hits	800
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ERBB2_HUMAN
NC score	0.733006 (rank : 658)	θ value	1.63604e-09 (rank : 466)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1073	Shared Neighborhood Hits	799
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHB4_MOUSE
NC score	0.732318 (rank : 659)	θ value	9.59137e-10 (rank : 457)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1013	Shared Neighborhood Hits	754
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ROCK1_HUMAN
NC score	0.731859 (rank : 660)	θ value	1.99992e-07 (rank : 595)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2000	Shared Neighborhood Hits	805
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

FGR_MOUSE
NC score	0.730735 (rank : 661)	θ value	2.79066e-09 (rank : 485)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	761
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

EPHA1_HUMAN
NC score	0.729545 (rank : 662)	θ value	2.36244e-08 (rank : 540)
Query Neighborhood Hits	1407	Target Neighborhood Hits	997	Shared Neighborhood Hits	754
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA2_HUMAN
NC score	0.728957 (rank : 663)	θ value	6.21693e-09 (rank : 508)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1021	Shared Neighborhood Hits	759
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB4_HUMAN
NC score	0.728932 (rank : 664)	θ value	9.59137e-10 (rank : 456)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	757
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA5_HUMAN
NC score	0.728611 (rank : 665)	θ value	1.38499e-08 (rank : 527)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	759
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA3_MOUSE
NC score	0.728444 (rank : 666)	θ value	2.52405e-10 (rank : 421)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1009	Shared Neighborhood Hits	763
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

NTRK2_MOUSE
NC score	0.727820 (rank : 667)	θ value	1.29631e-06 (rank : 637)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1088	Shared Neighborhood Hits	742
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.727642 (rank : 668)	θ value	2.21117e-06 (rank : 645)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1081	Shared Neighborhood Hits	742
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

RON_HUMAN
NC score	0.727584 (rank : 669)	θ value	0.000461057 (rank : 724)
Query Neighborhood Hits	1407	Target Neighborhood Hits	842	Shared Neighborhood Hits	740
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROCK2_MOUSE
NC score	0.727524 (rank : 670)	θ value	9.92553e-07 (rank : 635)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2072	Shared Neighborhood Hits	795
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

EPHA7_MOUSE
NC score	0.725930 (rank : 671)	θ value	4.76016e-09 (rank : 500)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1025	Shared Neighborhood Hits	756
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

ACVL1_MOUSE
NC score	0.725868 (rank : 672)	θ value	8.97725e-08 (rank : 573)
Query Neighborhood Hits	1407	Target Neighborhood Hits	739	Shared Neighborhood Hits	690
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

MRCKB_MOUSE
NC score	0.724524 (rank : 673)	θ value	2.36244e-08 (rank : 544)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2180	Shared Neighborhood Hits	820
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

EPHB2_MOUSE
NC score	0.724495 (rank : 674)	θ value	1.38499e-08 (rank : 529)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	751
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA7_HUMAN
NC score	0.724420 (rank : 675)	θ value	8.11959e-09 (rank : 516)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1053	Shared Neighborhood Hits	760
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB2_HUMAN
NC score	0.724408 (rank : 676)	θ value	1.38499e-08 (rank : 528)
Query Neighborhood Hits	1407	Target Neighborhood Hits	983	Shared Neighborhood Hits	751
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

FGFR2_MOUSE
NC score	0.723996 (rank : 677)	θ value	9.29e-05 (rank : 697)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1062	Shared Neighborhood Hits	747
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

EPHA2_MOUSE
NC score	0.722970 (rank : 678)	θ value	6.87365e-08 (rank : 566)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FGFR2_HUMAN
NC score	0.721966 (rank : 679)	θ value	9.29e-05 (rank : 696)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1062	Shared Neighborhood Hits	747
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

EPHA4_HUMAN
NC score	0.721682 (rank : 680)	θ value	8.97725e-08 (rank : 574)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	758
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.721474 (rank : 681)	θ value	8.97725e-08 (rank : 575)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	758
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

MET_MOUSE
NC score	0.721460 (rank : 682)	θ value	θ > 10 (rank : 1518)
Query Neighborhood Hits	1407	Target Neighborhood Hits	844	Shared Neighborhood Hits	737
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA8_HUMAN
NC score	0.720246 (rank : 683)	θ value	2.61198e-07 (rank : 602)
Query Neighborhood Hits	1407	Target Neighborhood Hits	956	Shared Neighborhood Hits	752
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

MET_HUMAN
NC score	0.719088 (rank : 684)	θ value	θ > 10 (rank : 1517)
Query Neighborhood Hits	1407	Target Neighborhood Hits	831	Shared Neighborhood Hits	734
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA1_MOUSE
NC score	0.718709 (rank : 685)	θ value	6.87365e-08 (rank : 565)
Query Neighborhood Hits	1407	Target Neighborhood Hits	958	Shared Neighborhood Hits	742
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

CLK1_MOUSE
NC score	0.718443 (rank : 686)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	677
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

INSR_HUMAN
NC score	0.718403 (rank : 687)	θ value	3.64472e-09 (rank : 495)
Query Neighborhood Hits	1407	Target Neighborhood Hits	963	Shared Neighborhood Hits	748
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

RON_MOUSE
NC score	0.717740 (rank : 688)	θ value	0.00020696 (rank : 710)
Query Neighborhood Hits	1407	Target Neighborhood Hits	836	Shared Neighborhood Hits	734
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

CTRO_MOUSE
NC score	0.717591 (rank : 689)	θ value	5.81887e-07 (rank : 622)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2344	Shared Neighborhood Hits	836
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

FGFR1_MOUSE
NC score	0.717071 (rank : 690)	θ value	0.000270298 (rank : 714)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1068	Shared Neighborhood Hits	750
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

MRCKB_HUMAN
NC score	0.717052 (rank : 691)	θ value	3.08544e-08 (rank : 553)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2239	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

ROCK1_MOUSE
NC score	0.717019 (rank : 692)	θ value	1.99992e-07 (rank : 596)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2126	Shared Neighborhood Hits	813
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

FGFR1_HUMAN
NC score	0.716977 (rank : 693)	θ value	0.000270298 (rank : 713)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	751
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

AATK_HUMAN
NC score	0.716936 (rank : 694)	θ value	0.21417 (rank : 862)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1243	Shared Neighborhood Hits	858
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHB3_HUMAN
NC score	0.716543 (rank : 695)	θ value	5.62301e-10 (rank : 448)
Query Neighborhood Hits	1407	Target Neighborhood Hits	996	Shared Neighborhood Hits	756
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

PINK1_HUMAN
NC score	0.716158 (rank : 696)	θ value	θ > 10 (rank : 1547)
Query Neighborhood Hits	1407	Target Neighborhood Hits	741	Shared Neighborhood Hits	664
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

CLK1_HUMAN
NC score	0.716022 (rank : 697)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	1407	Target Neighborhood Hits	756	Shared Neighborhood Hits	671
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

EPHA8_MOUSE
NC score	0.715943 (rank : 698)	θ value	7.59969e-07 (rank : 627)
Query Neighborhood Hits	1407	Target Neighborhood Hits	969	Shared Neighborhood Hits	753
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

AATK_MOUSE
NC score	0.715906 (rank : 699)	θ value	5.81887e-07 (rank : 619)
Query Neighborhood Hits	1407	Target Neighborhood Hits	942	Shared Neighborhood Hits	768
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

INSR_MOUSE
NC score	0.715464 (rank : 700)	θ value	3.08544e-08 (rank : 550)
Query Neighborhood Hits	1407	Target Neighborhood Hits	968	Shared Neighborhood Hits	744
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHB3_MOUSE
NC score	0.714893 (rank : 701)	θ value	2.13673e-09 (rank : 474)
Query Neighborhood Hits	1407	Target Neighborhood Hits	996	Shared Neighborhood Hits	755
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ERBB3_MOUSE
NC score	0.713749 (rank : 702)	θ value	1.06045e-08 (rank : 523)
Query Neighborhood Hits	1407	Target Neighborhood Hits	898	Shared Neighborhood Hits	729
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

CLK4_HUMAN
NC score	0.712458 (rank : 703)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	681
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

DDR2_MOUSE
NC score	0.711894 (rank : 704)	θ value	0.000461057 (rank : 721)
Query Neighborhood Hits	1407	Target Neighborhood Hits	813	Shared Neighborhood Hits	721
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FGFR3_HUMAN
NC score	0.711585 (rank : 705)	θ value	3.19293e-05 (rank : 677)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1042	Shared Neighborhood Hits	747
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ROS_HUMAN
NC score	0.711474 (rank : 706)	θ value	1.99992e-07 (rank : 597)
Query Neighborhood Hits	1407	Target Neighborhood Hits	907	Shared Neighborhood Hits	716
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

NTRK1_HUMAN
NC score	0.711357 (rank : 707)	θ value	3.08544e-08 (rank : 554)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	728
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

CLK4_MOUSE
NC score	0.711130 (rank : 708)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	1407	Target Neighborhood Hits	759	Shared Neighborhood Hits	679
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

ROR1_MOUSE
NC score	0.709701 (rank : 709)	θ value	0.00134147 (rank : 732)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1025	Shared Neighborhood Hits	740
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FGFR3_MOUSE
NC score	0.708410 (rank : 710)	θ value	0.00020696 (rank : 709)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1059	Shared Neighborhood Hits	750
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

ROR1_HUMAN
NC score	0.707408 (rank : 711)	θ value	0.00102713 (rank : 728)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1018	Shared Neighborhood Hits	741
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ACVL1_HUMAN
NC score	0.707267 (rank : 712)	θ value	2.88788e-06 (rank : 647)
Query Neighborhood Hits	1407	Target Neighborhood Hits	716	Shared Neighborhood Hits	666
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TIE2_HUMAN
NC score	0.705427 (rank : 713)	θ value	θ > 10 (rank : 1616)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1192	Shared Neighborhood Hits	752
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.704657 (rank : 714)	θ value	θ > 10 (rank : 1617)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1204	Shared Neighborhood Hits	754
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

UFO_MOUSE
NC score	0.704118 (rank : 715)	θ value	1.53129e-07 (rank : 589)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	711
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

STYK1_HUMAN
NC score	0.703569 (rank : 716)	θ value	θ > 10 (rank : 1606)
Query Neighborhood Hits	1407	Target Neighborhood Hits	786	Shared Neighborhood Hits	712
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

IGF1R_MOUSE
NC score	0.703378 (rank : 717)	θ value	3.64472e-09 (rank : 494)
Query Neighborhood Hits	1407	Target Neighborhood Hits	973	Shared Neighborhood Hits	735
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

CLK2_HUMAN
NC score	0.703149 (rank : 718)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	1407	Target Neighborhood Hits	752	Shared Neighborhood Hits	664
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

ERBB3_HUMAN
NC score	0.703099 (rank : 719)	θ value	θ > 10 (rank : 1463)
Query Neighborhood Hits	1407	Target Neighborhood Hits	918	Shared Neighborhood Hits	727
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

IGF1R_HUMAN
NC score	0.702709 (rank : 720)	θ value	2.13673e-09 (rank : 475)
Query Neighborhood Hits	1407	Target Neighborhood Hits	977	Shared Neighborhood Hits	734
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

FGFR4_HUMAN
NC score	0.702188 (rank : 721)	θ value	0.000121331 (rank : 699)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	742
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

NTRK3_HUMAN
NC score	0.701764 (rank : 722)	θ value	7.59969e-07 (rank : 630)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1115	Shared Neighborhood Hits	739
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

ACV1C_MOUSE
NC score	0.701083 (rank : 723)	θ value	2.61198e-07 (rank : 600)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	656
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

INSRR_MOUSE
NC score	0.700784 (rank : 724)	θ value	4.0297e-08 (rank : 558)
Query Neighborhood Hits	1407	Target Neighborhood Hits	961	Shared Neighborhood Hits	727
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IRAK3_MOUSE
NC score	0.700724 (rank : 725)	θ value	0.0330416 (rank : 816)
Query Neighborhood Hits	1407	Target Neighborhood Hits	628	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK2_HUMAN
NC score	0.700381 (rank : 726)	θ value	θ > 10 (rank : 1490)
Query Neighborhood Hits	1407	Target Neighborhood Hits	714	Shared Neighborhood Hits	650
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

UFO_HUMAN
NC score	0.700200 (rank : 727)	θ value	2.61198e-07 (rank : 608)
Query Neighborhood Hits	1407	Target Neighborhood Hits	981	Shared Neighborhood Hits	714
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

DDR2_HUMAN
NC score	0.699506 (rank : 728)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

TRIB1_HUMAN
NC score	0.698482 (rank : 729)	θ value	θ > 10 (rank : 1618)
Query Neighborhood Hits	1407	Target Neighborhood Hits	598	Shared Neighborhood Hits	548
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

INSRR_HUMAN
NC score	0.697814 (rank : 730)	θ value	5.81887e-07 (rank : 623)
Query Neighborhood Hits	1407	Target Neighborhood Hits	950	Shared Neighborhood Hits	729
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ACV1C_HUMAN
NC score	0.697791 (rank : 731)	θ value	4.45536e-07 (rank : 616)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	652
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

TRIB1_MOUSE
NC score	0.697467 (rank : 732)	θ value	θ > 10 (rank : 1619)
Query Neighborhood Hits	1407	Target Neighborhood Hits	593	Shared Neighborhood Hits	550
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

MLKL_HUMAN
NC score	0.697397 (rank : 733)	θ value	3.29651e-10 (rank : 432)
Query Neighborhood Hits	1407	Target Neighborhood Hits	600	Shared Neighborhood Hits	541
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TYRO3_HUMAN
NC score	0.693400 (rank : 734)	θ value	1.87187e-05 (rank : 671)
Query Neighborhood Hits	1407	Target Neighborhood Hits	995	Shared Neighborhood Hits	725
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
NC score	0.693096 (rank : 735)	θ value	4.92598e-06 (rank : 656)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1007	Shared Neighborhood Hits	726
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ROR2_HUMAN
NC score	0.692834 (rank : 736)	θ value	0.00102713 (rank : 729)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1014	Shared Neighborhood Hits	739
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

MERTK_MOUSE
NC score	0.691838 (rank : 737)	θ value	7.59969e-07 (rank : 628)
Query Neighborhood Hits	1407	Target Neighborhood Hits	974	Shared Neighborhood Hits	712
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

STYK1_MOUSE
NC score	0.690085 (rank : 738)	θ value	θ > 10 (rank : 1607)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	704
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CLK2_MOUSE
NC score	0.689228 (rank : 739)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	1407	Target Neighborhood Hits	743	Shared Neighborhood Hits	660
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

TIE1_MOUSE
NC score	0.688982 (rank : 740)	θ value	θ > 10 (rank : 1615)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1266	Shared Neighborhood Hits	758
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

IRAK3_HUMAN
NC score	0.688940 (rank : 741)	θ value	1.81305 (rank : 1064)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	593
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TIE1_HUMAN
NC score	0.687280 (rank : 742)	θ value	θ > 10 (rank : 1614)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1241	Shared Neighborhood Hits	756
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CLK3_HUMAN
NC score	0.687216 (rank : 743)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	1407	Target Neighborhood Hits	748	Shared Neighborhood Hits	662
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.686558 (rank : 744)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	1407	Target Neighborhood Hits	761	Shared Neighborhood Hits	662
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

DDR1_MOUSE
NC score	0.686464 (rank : 745)	θ value	0.00390308 (rank : 754)
Query Neighborhood Hits	1407	Target Neighborhood Hits	818	Shared Neighborhood Hits	718
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

TRIB3_MOUSE
NC score	0.686117 (rank : 746)	θ value	θ > 10 (rank : 1621)
Query Neighborhood Hits	1407	Target Neighborhood Hits	578	Shared Neighborhood Hits	551
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

DDR1_HUMAN
NC score	0.684662 (rank : 747)	θ value	0.000602161 (rank : 726)
Query Neighborhood Hits	1407	Target Neighborhood Hits	819	Shared Neighborhood Hits	722
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

MERTK_HUMAN
NC score	0.684205 (rank : 748)	θ value	2.88788e-06 (rank : 649)
Query Neighborhood Hits	1407	Target Neighborhood Hits	988	Shared Neighborhood Hits	721
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ANKK1_MOUSE
NC score	0.684200 (rank : 749)	θ value	1.33837e-11 (rank : 335)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1072	Shared Neighborhood Hits	741
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

TTBK1_HUMAN
NC score	0.683131 (rank : 750)	θ value	3.0926 (rank : 1161)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1058	Shared Neighborhood Hits	745
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EPHA6_MOUSE
NC score	0.681191 (rank : 751)	θ value	7.1131e-05 (rank : 689)
Query Neighborhood Hits	1407	Target Neighborhood Hits	946	Shared Neighborhood Hits	748
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ALK_HUMAN
NC score	0.679878 (rank : 752)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	683
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

FGFR4_MOUSE
NC score	0.679632 (rank : 753)	θ value	0.00509761 (rank : 765)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1026	Shared Neighborhood Hits	734
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

RIPK4_HUMAN
NC score	0.679239 (rank : 754)	θ value	6.64225e-11 (rank : 390)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1094	Shared Neighborhood Hits	749
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ALK_MOUSE
NC score	0.677794 (rank : 755)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	695
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.675303 (rank : 756)	θ value	6.43352e-06 (rank : 660)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	691
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LTK_HUMAN
NC score	0.674741 (rank : 757)	θ value	3.41135e-07 (rank : 613)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	689
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

ANKK1_HUMAN
NC score	0.673140 (rank : 758)	θ value	3.64472e-09 (rank : 490)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1075	Shared Neighborhood Hits	738
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

EPHA6_HUMAN
NC score	0.671074 (rank : 759)	θ value	0.00020696 (rank : 708)
Query Neighborhood Hits	1407	Target Neighborhood Hits	959	Shared Neighborhood Hits	749
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ROR2_MOUSE
NC score	0.669341 (rank : 760)	θ value	0.0113563 (rank : 790)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1000	Shared Neighborhood Hits	719
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

NRBP_HUMAN
NC score	0.665183 (rank : 761)	θ value	5.22648e-32 (rank : 7)
Query Neighborhood Hits	1407	Target Neighborhood Hits	448	Shared Neighborhood Hits	405
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

PTK7_HUMAN
NC score	0.662974 (rank : 762)	θ value	2.44474e-05 (rank : 674)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	729
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

AMHR2_HUMAN
NC score	0.662565 (rank : 763)	θ value	1.99992e-07 (rank : 592)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	636
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

NRBP_MOUSE
NC score	0.662236 (rank : 764)	θ value	4.42448e-31 (rank : 8)
Query Neighborhood Hits	1407	Target Neighborhood Hits	442	Shared Neighborhood Hits	402
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

TTBK2_HUMAN
NC score	0.660414 (rank : 765)	θ value	θ > 10 (rank : 1622)
Query Neighborhood Hits	1407	Target Neighborhood Hits	822	Shared Neighborhood Hits	675
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
NC score	0.657915 (rank : 766)	θ value	θ > 10 (rank : 1623)
Query Neighborhood Hits	1407	Target Neighborhood Hits	811	Shared Neighborhood Hits	658
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TITIN_HUMAN
NC score	0.656492 (rank : 767)	θ value	6.88961 (rank : 1329)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2923	Shared Neighborhood Hits	955
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRIB3_HUMAN
NC score	0.652665 (rank : 768)	θ value	θ > 10 (rank : 1620)
Query Neighborhood Hits	1407	Target Neighborhood Hits	519	Shared Neighborhood Hits	493
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

RPKL1_MOUSE
NC score	0.651370 (rank : 769)	θ value	θ > 10 (rank : 1569)
Query Neighborhood Hits	1407	Target Neighborhood Hits	704	Shared Neighborhood Hits	623
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

KIT_HUMAN
NC score	0.647927 (rank : 770)	θ value	0.00869519 (rank : 782)
Query Neighborhood Hits	1407	Target Neighborhood Hits	953	Shared Neighborhood Hits	733
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

RPKL1_HUMAN
NC score	0.647802 (rank : 771)	θ value	θ > 10 (rank : 1568)
Query Neighborhood Hits	1407	Target Neighborhood Hits	708	Shared Neighborhood Hits	613
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

MUSK_HUMAN
NC score	0.645225 (rank : 772)	θ value	θ > 10 (rank : 1522)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1074	Shared Neighborhood Hits	722
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

PGFRA_HUMAN
NC score	0.643574 (rank : 773)	θ value	θ > 10 (rank : 1542)
Query Neighborhood Hits	1407	Target Neighborhood Hits	980	Shared Neighborhood Hits	729
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
NC score	0.642813 (rank : 774)	θ value	θ > 10 (rank : 1543)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	727
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

MUSK_MOUSE
NC score	0.641367 (rank : 775)	θ value	θ > 10 (rank : 1523)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1057	Shared Neighborhood Hits	722
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

KC1A_HUMAN
NC score	0.640751 (rank : 776)	θ value	6.88961 (rank : 1298)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	666
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.640751 (rank : 777)	θ value	6.88961 (rank : 1299)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	666
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1AL_HUMAN
NC score	0.640572 (rank : 778)	θ value	0.813845 (rank : 966)
Query Neighborhood Hits	1407	Target Neighborhood Hits	734	Shared Neighborhood Hits	674
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KIT_MOUSE
NC score	0.639069 (rank : 779)	θ value	0.0148317 (rank : 793)
Query Neighborhood Hits	1407	Target Neighborhood Hits	949	Shared Neighborhood Hits	732
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

VGFR1_MOUSE
NC score	0.638243 (rank : 780)	θ value	7.1131e-05 (rank : 694)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1118	Shared Neighborhood Hits	739
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

PGFRB_HUMAN
NC score	0.637991 (rank : 781)	θ value	θ > 10 (rank : 1544)
Query Neighborhood Hits	1407	Target Neighborhood Hits	962	Shared Neighborhood Hits	731
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KC1D_MOUSE
NC score	0.637580 (rank : 782)	θ value	θ > 10 (rank : 1498)
Query Neighborhood Hits	1407	Target Neighborhood Hits	737	Shared Neighborhood Hits	663
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_HUMAN
NC score	0.637565 (rank : 783)	θ value	θ > 10 (rank : 1497)
Query Neighborhood Hits	1407	Target Neighborhood Hits	737	Shared Neighborhood Hits	663
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

VGFR3_MOUSE
NC score	0.637305 (rank : 784)	θ value	θ > 10 (rank : 1639)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1056	Shared Neighborhood Hits	734
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FLT3_HUMAN
NC score	0.637143 (rank : 785)	θ value	θ > 10 (rank : 1465)
Query Neighborhood Hits	1407	Target Neighborhood Hits	843	Shared Neighborhood Hits	723
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

PGFRB_MOUSE
NC score	0.636907 (rank : 786)	θ value	θ > 10 (rank : 1545)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	732
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VGFR3_HUMAN
NC score	0.635760 (rank : 787)	θ value	θ > 10 (rank : 1638)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	733
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR2_MOUSE
NC score	0.634344 (rank : 788)	θ value	θ > 10 (rank : 1637)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1089	Shared Neighborhood Hits	739
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

CDC7_HUMAN
NC score	0.634072 (rank : 789)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	1407	Target Neighborhood Hits	652	Shared Neighborhood Hits	584
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

KC1E_HUMAN
NC score	0.633166 (rank : 790)	θ value	θ > 10 (rank : 1499)
Query Neighborhood Hits	1407	Target Neighborhood Hits	732	Shared Neighborhood Hits	663
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.633136 (rank : 791)	θ value	θ > 10 (rank : 1500)
Query Neighborhood Hits	1407	Target Neighborhood Hits	728	Shared Neighborhood Hits	662
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

FLT3_MOUSE
NC score	0.632767 (rank : 792)	θ value	θ > 10 (rank : 1466)
Query Neighborhood Hits	1407	Target Neighborhood Hits	847	Shared Neighborhood Hits	727
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

VGFR1_HUMAN
NC score	0.630399 (rank : 793)	θ value	θ > 10 (rank : 1635)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1109	Shared Neighborhood Hits	738
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

CDC7_MOUSE
NC score	0.630283 (rank : 794)	θ value	5.27518 (rank : 1214)
Query Neighborhood Hits	1407	Target Neighborhood Hits	641	Shared Neighborhood Hits	583
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

EPHAA_HUMAN
NC score	0.629787 (rank : 795)	θ value	0.00228821 (rank : 741)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	705
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

KS6C1_MOUSE
NC score	0.629674 (rank : 796)	θ value	θ > 10 (rank : 1507)
Query Neighborhood Hits	1407	Target Neighborhood Hits	700	Shared Neighborhood Hits	600
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

VGFR2_HUMAN
NC score	0.625890 (rank : 797)	θ value	θ > 10 (rank : 1636)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	739
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

EPHB6_MOUSE
NC score	0.625198 (rank : 798)	θ value	6.43352e-06 (rank : 658)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	679
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

KS6C1_HUMAN
NC score	0.623445 (rank : 799)	θ value	θ > 10 (rank : 1506)
Query Neighborhood Hits	1407	Target Neighborhood Hits	682	Shared Neighborhood Hits	597
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

RYK_MOUSE
NC score	0.620924 (rank : 800)	θ value	0.0330416 (rank : 820)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	654
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

CSF1R_HUMAN
NC score	0.611338 (rank : 801)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	1407	Target Neighborhood Hits	943	Shared Neighborhood Hits	726
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

GUC2F_HUMAN
NC score	0.610338 (rank : 802)	θ value	0.000158464 (rank : 703)
Query Neighborhood Hits	1407	Target Neighborhood Hits	740	Shared Neighborhood Hits	636
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

KC1G1_MOUSE
NC score	0.609031 (rank : 803)	θ value	θ > 10 (rank : 1502)
Query Neighborhood Hits	1407	Target Neighborhood Hits	713	Shared Neighborhood Hits	640
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

EPHB6_HUMAN
NC score	0.608767 (rank : 804)	θ value	7.1131e-05 (rank : 690)
Query Neighborhood Hits	1407	Target Neighborhood Hits	912	Shared Neighborhood Hits	661
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

KC1G1_HUMAN
NC score	0.607760 (rank : 805)	θ value	θ > 10 (rank : 1501)
Query Neighborhood Hits	1407	Target Neighborhood Hits	708	Shared Neighborhood Hits	638
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

CSF1R_MOUSE
NC score	0.606855 (rank : 806)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	1407	Target Neighborhood Hits	983	Shared Neighborhood Hits	729
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

RYK_HUMAN
NC score	0.605924 (rank : 807)	θ value	0.21417 (rank : 874)
Query Neighborhood Hits	1407	Target Neighborhood Hits	701	Shared Neighborhood Hits	643
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

KC1G3_HUMAN
NC score	0.603352 (rank : 808)	θ value	θ > 10 (rank : 1505)
Query Neighborhood Hits	1407	Target Neighborhood Hits	711	Shared Neighborhood Hits	639
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

SCYL2_HUMAN
NC score	0.588194 (rank : 809)	θ value	θ > 10 (rank : 1570)
Query Neighborhood Hits	1407	Target Neighborhood Hits	632	Shared Neighborhood Hits	538
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

KC1G2_MOUSE
NC score	0.582303 (rank : 810)	θ value	θ > 10 (rank : 1504)
Query Neighborhood Hits	1407	Target Neighborhood Hits	695	Shared Neighborhood Hits	628
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_HUMAN
NC score	0.580503 (rank : 811)	θ value	θ > 10 (rank : 1503)
Query Neighborhood Hits	1407	Target Neighborhood Hits	693	Shared Neighborhood Hits	627
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

SCYL2_MOUSE
NC score	0.565174 (rank : 812)	θ value	θ > 10 (rank : 1571)
Query Neighborhood Hits	1407	Target Neighborhood Hits	603	Shared Neighborhood Hits	517
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ANPRB_HUMAN
NC score	0.564712 (rank : 813)	θ value	0.000602161 (rank : 725)
Query Neighborhood Hits	1407	Target Neighborhood Hits	646	Shared Neighborhood Hits	546
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.557410 (rank : 814)	θ value	θ > 10 (rank : 1484)
Query Neighborhood Hits	1407	Target Neighborhood Hits	624	Shared Neighborhood Hits	543
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
NC score	0.547872 (rank : 815)	θ value	θ > 10 (rank : 1485)
Query Neighborhood Hits	1407	Target Neighborhood Hits	715	Shared Neighborhood Hits	627
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
NC score	0.546246 (rank : 816)	θ value	0.00665767 (rank : 774)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	548
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

BUB1_MOUSE
NC score	0.539814 (rank : 817)	θ value	1.81305 (rank : 1049)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	498
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

ANPRA_MOUSE
NC score	0.536714 (rank : 818)	θ value	6.43352e-06 (rank : 657)
Query Neighborhood Hits	1407	Target Neighborhood Hits	600	Shared Neighborhood Hits	507
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_MOUSE
NC score	0.536598 (rank : 819)	θ value	0.00298849 (rank : 746)
Query Neighborhood Hits	1407	Target Neighborhood Hits	607	Shared Neighborhood Hits	525
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
NC score	0.535096 (rank : 820)	θ value	0.00020696 (rank : 706)
Query Neighborhood Hits	1407	Target Neighborhood Hits	612	Shared Neighborhood Hits	511
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

TEX14_MOUSE
NC score	0.535092 (rank : 821)	θ value	θ > 10 (rank : 1613)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1333	Shared Neighborhood Hits	629
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

SRPK1_MOUSE
NC score	0.534547 (rank : 822)	θ value	0.00175202 (rank : 736)
Query Neighborhood Hits	1407	Target Neighborhood Hits	639	Shared Neighborhood Hits	528
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_HUMAN
NC score	0.533635 (rank : 823)	θ value	0.00175202 (rank : 735)
Query Neighborhood Hits	1407	Target Neighborhood Hits	706	Shared Neighborhood Hits	553
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

GUC2E_MOUSE
NC score	0.531322 (rank : 824)	θ value	θ > 10 (rank : 1486)
Query Neighborhood Hits	1407	Target Neighborhood Hits	692	Shared Neighborhood Hits	605
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

SRPK2_HUMAN
NC score	0.529907 (rank : 825)	θ value	0.00175202 (rank : 737)
Query Neighborhood Hits	1407	Target Neighborhood Hits	664	Shared Neighborhood Hits	536
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
NC score	0.526937 (rank : 826)	θ value	0.00175202 (rank : 738)
Query Neighborhood Hits	1407	Target Neighborhood Hits	765	Shared Neighborhood Hits	552
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_MOUSE
NC score	0.526377 (rank : 827)	θ value	0.00298849 (rank : 751)
Query Neighborhood Hits	1407	Target Neighborhood Hits	572	Shared Neighborhood Hits	517
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.525021 (rank : 828)	θ value	0.00298849 (rank : 750)
Query Neighborhood Hits	1407	Target Neighborhood Hits	556	Shared Neighborhood Hits	513
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

ILK1_HUMAN
NC score	0.523956 (rank : 829)	θ value	5.44631e-05 (rank : 684)
Query Neighborhood Hits	1407	Target Neighborhood Hits	857	Shared Neighborhood Hits	552
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.521548 (rank : 830)	θ value	0.000121331 (rank : 701)
Query Neighborhood Hits	1407	Target Neighborhood Hits	858	Shared Neighborhood Hits	553
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

TEX14_HUMAN
NC score	0.510268 (rank : 831)	θ value	0.47712 (rank : 935)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1103	Shared Neighborhood Hits	588
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ILK2_HUMAN
NC score	0.509525 (rank : 832)	θ value	7.1131e-05 (rank : 691)
Query Neighborhood Hits	1407	Target Neighborhood Hits	848	Shared Neighborhood Hits	545
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

VRK2_MOUSE
NC score	0.447514 (rank : 833)	θ value	θ > 10 (rank : 1643)
Query Neighborhood Hits	1407	Target Neighborhood Hits	586	Shared Neighborhood Hits	531
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_HUMAN
NC score	0.445549 (rank : 834)	θ value	θ > 10 (rank : 1642)
Query Neighborhood Hits	1407	Target Neighborhood Hits	582	Shared Neighborhood Hits	521
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.442938 (rank : 835)	θ value	θ > 10 (rank : 1641)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	530
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK1_HUMAN
NC score	0.439967 (rank : 836)	θ value	θ > 10 (rank : 1640)
Query Neighborhood Hits	1407	Target Neighborhood Hits	584	Shared Neighborhood Hits	532
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

NTKL_MOUSE
NC score	0.398101 (rank : 837)	θ value	0.0193708 (rank : 802)
Query Neighborhood Hits	1407	Target Neighborhood Hits	326	Shared Neighborhood Hits	289
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

BUB1_HUMAN
NC score	0.362124 (rank : 838)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	388
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

STK31_HUMAN
NC score	0.356523 (rank : 839)	θ value	θ > 10 (rank : 1604)
Query Neighborhood Hits	1407	Target Neighborhood Hits	570	Shared Neighborhood Hits	352
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

PI3R4_MOUSE
NC score	0.340238 (rank : 840)	θ value	θ > 10 (rank : 1546)
Query Neighborhood Hits	1407	Target Neighborhood Hits	535	Shared Neighborhood Hits	351
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

RN5A_MOUSE
NC score	0.334801 (rank : 841)	θ value	θ > 10 (rank : 1567)
Query Neighborhood Hits	1407	Target Neighborhood Hits	899	Shared Neighborhood Hits	585
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

PI3R4_HUMAN
NC score	0.327246 (rank : 842)	θ value	5.27518 (rank : 1245)
Query Neighborhood Hits	1407	Target Neighborhood Hits	534	Shared Neighborhood Hits	341
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

NTKL_HUMAN
NC score	0.312500 (rank : 843)	θ value	0.21417 (rank : 871)
Query Neighborhood Hits	1407	Target Neighborhood Hits	266	Shared Neighborhood Hits	224
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

STK31_MOUSE
NC score	0.302827 (rank : 844)	θ value	θ > 10 (rank : 1605)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	293
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

K2002_HUMAN
NC score	0.281119 (rank : 845)	θ value	θ > 10 (rank : 1495)
Query Neighborhood Hits	1407	Target Neighborhood Hits	274	Shared Neighborhood Hits	237
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

VRK3_HUMAN
NC score	0.235046 (rank : 846)	θ value	θ > 10 (rank : 1644)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	293
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

K2002_MOUSE
NC score	0.231508 (rank : 847)	θ value	θ > 10 (rank : 1496)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	210
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PXK_MOUSE
NC score	0.222183 (rank : 848)	θ value	0.00298849 (rank : 749)
Query Neighborhood Hits	1407	Target Neighborhood Hits	320	Shared Neighborhood Hits	218
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

VRK3_MOUSE
NC score	0.219498 (rank : 849)	θ value	θ > 10 (rank : 1645)
Query Neighborhood Hits	1407	Target Neighborhood Hits	342	Shared Neighborhood Hits	287
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

PXK_HUMAN
NC score	0.175614 (rank : 850)	θ value	0.00390308 (rank : 763)
Query Neighborhood Hits	1407	Target Neighborhood Hits	216	Shared Neighborhood Hits	145
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PRPK_MOUSE
NC score	0.154663 (rank : 851)	θ value	θ > 10 (rank : 1560)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	125
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

RN5A_HUMAN
NC score	0.153854 (rank : 852)	θ value	θ > 10 (rank : 1566)
Query Neighborhood Hits	1407	Target Neighborhood Hits	608	Shared Neighborhood Hits	332
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SLAP2_MOUSE
NC score	0.152231 (rank : 853)	θ value	θ > 10 (rank : 1595)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

PRPK_HUMAN
NC score	0.151655 (rank : 854)	θ value	θ > 10 (rank : 1559)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	119
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

SLAP2_HUMAN
NC score	0.147923 (rank : 855)	θ value	θ > 10 (rank : 1594)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_HUMAN
NC score	0.145680 (rank : 856)	θ value	θ > 10 (rank : 1592)
Query Neighborhood Hits	1407	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.143842 (rank : 857)	θ value	θ > 10 (rank : 1593)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

NACAM_MOUSE
NC score	0.125191 (rank : 858)	θ value	8.40245e-06 (rank : 663)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1866	Shared Neighborhood Hits	482
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GSCR1_HUMAN
NC score	0.124649 (rank : 859)	θ value	0.00035302 (rank : 717)
Query Neighborhood Hits	1407	Target Neighborhood Hits	674	Shared Neighborhood Hits	311
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

GRAP_HUMAN
NC score	0.113391 (rank : 860)	θ value	θ > 10 (rank : 1470)
Query Neighborhood Hits	1407	Target Neighborhood Hits	307	Shared Neighborhood Hits	77
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SON_HUMAN
NC score	0.113221 (rank : 861)	θ value	3.18553e-13 (rank : 243)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1568	Shared Neighborhood Hits	415
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GRAP_MOUSE
NC score	0.112799 (rank : 862)	θ value	θ > 10 (rank : 1471)
Query Neighborhood Hits	1407	Target Neighborhood Hits	309	Shared Neighborhood Hits	74
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP2_HUMAN
NC score	0.111428 (rank : 863)	θ value	θ > 10 (rank : 1468)
Query Neighborhood Hits	1407	Target Neighborhood Hits	304	Shared Neighborhood Hits	73
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.109403 (rank : 864)	θ value	θ > 10 (rank : 1469)
Query Neighborhood Hits	1407	Target Neighborhood Hits	297	Shared Neighborhood Hits	69
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB2_HUMAN
NC score	0.109194 (rank : 865)	θ value	θ > 10 (rank : 1474)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.109160 (rank : 866)	θ value	θ > 10 (rank : 1475)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	71
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MUC7_HUMAN
NC score	0.107251 (rank : 867)	θ value	0.813845 (rank : 968)
Query Neighborhood Hits	1407	Target Neighborhood Hits	538	Shared Neighborhood Hits	238
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MDC1_HUMAN
NC score	0.107205 (rank : 868)	θ value	1.99992e-07 (rank : 593)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1446	Shared Neighborhood Hits	341
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NCK2_HUMAN
NC score	0.106842 (rank : 869)	θ value	θ > 10 (rank : 1525)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	73
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.106013 (rank : 870)	θ value	θ > 10 (rank : 1524)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	71
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PRP2_MOUSE
NC score	0.105035 (rank : 871)	θ value	θ > 10 (rank : 1558)
Query Neighborhood Hits	1407	Target Neighborhood Hits	347	Shared Neighborhood Hits	180
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

STAC3_MOUSE
NC score	0.104758 (rank : 872)	θ value	θ > 10 (rank : 1601)
Query Neighborhood Hits	1407	Target Neighborhood Hits	232	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.104505 (rank : 873)	θ value	θ > 10 (rank : 1600)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	76
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRRM2_MOUSE
NC score	0.104330 (rank : 874)	θ value	0.0961366 (rank : 846)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1470	Shared Neighborhood Hits	356
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PRR12_HUMAN
NC score	0.103668 (rank : 875)	θ value	5.27518 (rank : 1246)
Query Neighborhood Hits	1407	Target Neighborhood Hits	460	Shared Neighborhood Hits	236
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SRRM1_MOUSE
NC score	0.103234 (rank : 876)	θ value	4.03905 (rank : 1197)
Query Neighborhood Hits	1407	Target Neighborhood Hits	966	Shared Neighborhood Hits	292
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STAC_MOUSE
NC score	0.102798 (rank : 877)	θ value	θ > 10 (rank : 1603)
Query Neighborhood Hits	1407	Target Neighborhood Hits	268	Shared Neighborhood Hits	91
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BSN_MOUSE
NC score	0.101710 (rank : 878)	θ value	0.00228821 (rank : 740)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2057	Shared Neighborhood Hits	496
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

NCOA6_MOUSE
NC score	0.100435 (rank : 879)	θ value	0.00509761 (rank : 766)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1076	Shared Neighborhood Hits	321
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

TARSH_HUMAN
NC score	0.099548 (rank : 880)	θ value	0.0330416 (rank : 821)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	270
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

PRG4_HUMAN
NC score	0.099237 (rank : 881)	θ value	θ > 10 (rank : 1555)
Query Neighborhood Hits	1407	Target Neighborhood Hits	764	Shared Neighborhood Hits	265
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SH21B_MOUSE
NC score	0.098992 (rank : 882)	θ value	θ > 10 (rank : 1581)
Query Neighborhood Hits	1407	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PACE1_MOUSE
NC score	0.098909 (rank : 883)	θ value	0.0961366 (rank : 844)
Query Neighborhood Hits	1407	Target Neighborhood Hits	92	Shared Neighborhood Hits	62
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PRP1_HUMAN
NC score	0.098439 (rank : 884)	θ value	θ > 10 (rank : 1557)
Query Neighborhood Hits	1407	Target Neighborhood Hits	385	Shared Neighborhood Hits	184
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

TAF4_HUMAN
NC score	0.097854 (rank : 885)	θ value	3.0926 (rank : 1157)
Query Neighborhood Hits	1407	Target Neighborhood Hits	687	Shared Neighborhood Hits	251
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

BSN_HUMAN
NC score	0.097515 (rank : 886)	θ value	0.21417 (rank : 863)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1537	Shared Neighborhood Hits	409
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

NCOA6_HUMAN
NC score	0.096971 (rank : 887)	θ value	7.1131e-05 (rank : 692)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1202	Shared Neighborhood Hits	352
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

STAC_HUMAN
NC score	0.095570 (rank : 888)	θ value	θ > 10 (rank : 1602)
Query Neighborhood Hits	1407	Target Neighborhood Hits	276	Shared Neighborhood Hits	88
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

WASIP_HUMAN
NC score	0.095513 (rank : 889)	θ value	θ > 10 (rank : 1648)
Query Neighborhood Hits	1407	Target Neighborhood Hits	458	Shared Neighborhood Hits	233
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

MDC1_MOUSE
NC score	0.093854 (rank : 890)	θ value	0.00228821 (rank : 742)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	294
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

YLPM1_MOUSE
NC score	0.093720 (rank : 891)	θ value	0.0252991 (rank : 812)
Query Neighborhood Hits	1407	Target Neighborhood Hits	505	Shared Neighborhood Hits	222
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

GRP3_HUMAN
NC score	0.093394 (rank : 892)	θ value	θ > 10 (rank : 1483)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

VAV3_HUMAN
NC score	0.093116 (rank : 893)	θ value	θ > 10 (rank : 1631)
Query Neighborhood Hits	1407	Target Neighborhood Hits	398	Shared Neighborhood Hits	104
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.092758 (rank : 894)	θ value	θ > 10 (rank : 1632)
Query Neighborhood Hits	1407	Target Neighborhood Hits	404	Shared Neighborhood Hits	105
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PCLO_HUMAN
NC score	0.090798 (rank : 895)	θ value	0.0563607 (rank : 830)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2046	Shared Neighborhood Hits	459
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SRRM2_HUMAN
NC score	0.090757 (rank : 896)	θ value	1.06291 (rank : 1000)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1296	Shared Neighborhood Hits	339
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PCQAP_HUMAN
NC score	0.090039 (rank : 897)	θ value	0.813845 (rank : 969)
Query Neighborhood Hits	1407	Target Neighborhood Hits	549	Shared Neighborhood Hits	188
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

CN155_HUMAN
NC score	0.089993 (rank : 898)	θ value	1.38821 (rank : 1007)
Query Neighborhood Hits	1407	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

MUC1_HUMAN
NC score	0.089943 (rank : 899)	θ value	1.68911e-14 (rank : 181)
Query Neighborhood Hits	1407	Target Neighborhood Hits	975	Shared Neighborhood Hits	300
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

VAV_HUMAN
NC score	0.089920 (rank : 900)	θ value	θ > 10 (rank : 1633)
Query Neighborhood Hits	1407	Target Neighborhood Hits	452	Shared Neighborhood Hits	105
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.089820 (rank : 901)	θ value	θ > 10 (rank : 1629)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	107
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PRB4S_HUMAN
NC score	0.089576 (rank : 902)	θ value	θ > 10 (rank : 1554)
Query Neighborhood Hits	1407	Target Neighborhood Hits	330	Shared Neighborhood Hits	161
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SRRM1_HUMAN
NC score	0.089526 (rank : 903)	θ value	θ > 10 (rank : 1599)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	222
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SON_MOUSE
NC score	0.089126 (rank : 904)	θ value	0.00134147 (rank : 734)
Query Neighborhood Hits	1407	Target Neighborhood Hits	957	Shared Neighborhood Hits	270
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

PRRT3_HUMAN
NC score	0.089056 (rank : 905)	θ value	0.00035302 (rank : 719)
Query Neighborhood Hits	1407	Target Neighborhood Hits	998	Shared Neighborhood Hits	322
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PCLO_MOUSE
NC score	0.088946 (rank : 906)	θ value	0.0736092 (rank : 835)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2275	Shared Neighborhood Hits	512
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SH21A_MOUSE
NC score	0.088495 (rank : 907)	θ value	θ > 10 (rank : 1579)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

CN032_MOUSE
NC score	0.088306 (rank : 908)	θ value	0.279714 (rank : 880)
Query Neighborhood Hits	1407	Target Neighborhood Hits	233	Shared Neighborhood Hits	140
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

SH21B_HUMAN
NC score	0.088255 (rank : 909)	θ value	θ > 10 (rank : 1580)
Query Neighborhood Hits	1407	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

WASIP_MOUSE
NC score	0.087935 (rank : 910)	θ value	θ > 10 (rank : 1649)
Query Neighborhood Hits	1407	Target Neighborhood Hits	392	Shared Neighborhood Hits	215
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ENAH_MOUSE
NC score	0.087621 (rank : 911)	θ value	1.38821 (rank : 1012)
Query Neighborhood Hits	1407	Target Neighborhood Hits	919	Shared Neighborhood Hits	298
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

RASA1_HUMAN
NC score	0.087066 (rank : 912)	θ value	θ > 10 (rank : 1563)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PACE1_HUMAN
NC score	0.087047 (rank : 913)	θ value	4.03905 (rank : 1189)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

MBD6_HUMAN
NC score	0.086346 (rank : 914)	θ value	θ > 10 (rank : 1515)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	180
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

PRB3_HUMAN
NC score	0.086238 (rank : 915)	θ value	θ > 10 (rank : 1553)
Query Neighborhood Hits	1407	Target Neighborhood Hits	318	Shared Neighborhood Hits	148
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

OGFR_HUMAN
NC score	0.086123 (rank : 916)	θ value	0.0148317 (rank : 795)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1582	Shared Neighborhood Hits	396
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

VAV2_MOUSE
NC score	0.085578 (rank : 917)	θ value	θ > 10 (rank : 1630)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	108
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

RGS3_MOUSE
NC score	0.085080 (rank : 918)	θ value	3.41135e-07 (rank : 615)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1621	Shared Neighborhood Hits	405
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BUB1B_HUMAN
NC score	0.084777 (rank : 919)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1407	Target Neighborhood Hits	208	Shared Neighborhood Hits	108
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

VAV_MOUSE
NC score	0.084088 (rank : 920)	θ value	θ > 10 (rank : 1634)
Query Neighborhood Hits	1407	Target Neighborhood Hits	430	Shared Neighborhood Hits	102
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

RERE_MOUSE
NC score	0.083608 (rank : 921)	θ value	1.38821 (rank : 1032)
Query Neighborhood Hits	1407	Target Neighborhood Hits	785	Shared Neighborhood Hits	283
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

MLL2_HUMAN
NC score	0.083365 (rank : 922)	θ value	0.21417 (rank : 870)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1788	Shared Neighborhood Hits	437
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PRG4_MOUSE
NC score	0.083264 (rank : 923)	θ value	θ > 10 (rank : 1556)
Query Neighborhood Hits	1407	Target Neighborhood Hits	624	Shared Neighborhood Hits	208
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CN032_HUMAN
NC score	0.082793 (rank : 924)	θ value	5.27518 (rank : 1218)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

SH21A_HUMAN
NC score	0.082143 (rank : 925)	θ value	θ > 10 (rank : 1578)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

ATN1_HUMAN
NC score	0.082047 (rank : 926)	θ value	5.27518 (rank : 1210)
Query Neighborhood Hits	1407	Target Neighborhood Hits	676	Shared Neighborhood Hits	251
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

PRAX_HUMAN
NC score	0.081480 (rank : 927)	θ value	9.26847e-13 (rank : 267)
Query Neighborhood Hits	1407	Target Neighborhood Hits	215	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

MAGE1_HUMAN
NC score	0.080548 (rank : 928)	θ value	4.76016e-09 (rank : 503)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1389	Shared Neighborhood Hits	378
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

RERE_HUMAN
NC score	0.080443 (rank : 929)	θ value	1.38821 (rank : 1031)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	293
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

BAT2_HUMAN
NC score	0.080265 (rank : 930)	θ value	8.99809 (rank : 1340)
Query Neighborhood Hits	1407	Target Neighborhood Hits	931	Shared Neighborhood Hits	352
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CHIN_MOUSE
NC score	0.078503 (rank : 931)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	1407	Target Neighborhood Hits	229	Shared Neighborhood Hits	70
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.078497 (rank : 932)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	1407	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GGN_MOUSE
NC score	0.077982 (rank : 933)	θ value	θ > 10 (rank : 1467)
Query Neighborhood Hits	1407	Target Neighborhood Hits	311	Shared Neighborhood Hits	173
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

DAPP1_HUMAN
NC score	0.077616 (rank : 934)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CHIN_HUMAN
NC score	0.077542 (rank : 935)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	69
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CSKI1_HUMAN
NC score	0.076557 (rank : 936)	θ value	0.47712 (rank : 923)
Query Neighborhood Hits	1407	Target Neighborhood Hits	997	Shared Neighborhood Hits	309
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CBP_MOUSE
NC score	0.076123 (rank : 937)	θ value	0.00298849 (rank : 747)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1051	Shared Neighborhood Hits	327
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DGKD_HUMAN
NC score	0.076074 (rank : 938)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	77
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

PRAX_MOUSE
NC score	0.075611 (rank : 939)	θ value	2.88788e-06 (rank : 650)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	78
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

EP300_HUMAN
NC score	0.075562 (rank : 940)	θ value	0.62314 (rank : 942)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	292
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

PDZD8_HUMAN
NC score	0.075416 (rank : 941)	θ value	θ > 10 (rank : 1541)
Query Neighborhood Hits	1407	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

NU214_HUMAN
NC score	0.075413 (rank : 942)	θ value	0.0252991 (rank : 807)
Query Neighborhood Hits	1407	Target Neighborhood Hits	657	Shared Neighborhood Hits	168
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

CSKI1_MOUSE
NC score	0.075402 (rank : 943)	θ value	0.163984 (rank : 855)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1031	Shared Neighborhood Hits	325
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PCQAP_MOUSE
NC score	0.075394 (rank : 944)	θ value	4.03905 (rank : 1191)
Query Neighborhood Hits	1407	Target Neighborhood Hits	506	Shared Neighborhood Hits	167
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

DAPP1_MOUSE
NC score	0.075358 (rank : 945)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CBP_HUMAN
NC score	0.074595 (rank : 946)	θ value	0.0961366 (rank : 838)
Query Neighborhood Hits	1407	Target Neighborhood Hits	941	Shared Neighborhood Hits	307
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CRKL_MOUSE
NC score	0.074329 (rank : 947)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	1407	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.073818 (rank : 948)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	1407	Target Neighborhood Hits	313	Shared Neighborhood Hits	73
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

RGS3_HUMAN
NC score	0.073708 (rank : 949)	θ value	2.44474e-05 (rank : 675)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1375	Shared Neighborhood Hits	337
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

WIRE_HUMAN
NC score	0.072925 (rank : 950)	θ value	θ > 10 (rank : 1654)
Query Neighborhood Hits	1407	Target Neighborhood Hits	329	Shared Neighborhood Hits	172
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

PI5PA_HUMAN
NC score	0.072829 (rank : 951)	θ value	0.00228821 (rank : 744)
Query Neighborhood Hits	1407	Target Neighborhood Hits	749	Shared Neighborhood Hits	278
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

BCL9_HUMAN
NC score	0.071772 (rank : 952)	θ value	0.00390308 (rank : 753)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1008	Shared Neighborhood Hits	302
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

WASL_MOUSE
NC score	0.071492 (rank : 953)	θ value	θ > 10 (rank : 1651)
Query Neighborhood Hits	1407	Target Neighborhood Hits	339	Shared Neighborhood Hits	187
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

RASF1_MOUSE
NC score	0.071360 (rank : 954)	θ value	θ > 10 (rank : 1565)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

GGN_HUMAN
NC score	0.071261 (rank : 955)	θ value	6.88961 (rank : 1293)
Query Neighborhood Hits	1407	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

HSH2D_HUMAN
NC score	0.071173 (rank : 956)	θ value	θ > 10 (rank : 1487)
Query Neighborhood Hits	1407	Target Neighborhood Hits	159	Shared Neighborhood Hits	48
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SFPQ_HUMAN
NC score	0.071021 (rank : 957)	θ value	θ > 10 (rank : 1576)
Query Neighborhood Hits	1407	Target Neighborhood Hits	986	Shared Neighborhood Hits	290
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SYNJ1_MOUSE
NC score	0.070963 (rank : 958)	θ value	0.0431538 (rank : 824)
Query Neighborhood Hits	1407	Target Neighborhood Hits	516	Shared Neighborhood Hits	250
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SF3A2_MOUSE
NC score	0.070718 (rank : 959)	θ value	θ > 10 (rank : 1575)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	139
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

RAPH1_HUMAN
NC score	0.070374 (rank : 960)	θ value	θ > 10 (rank : 1562)
Query Neighborhood Hits	1407	Target Neighborhood Hits	593	Shared Neighborhood Hits	247
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

WBP11_HUMAN
NC score	0.070257 (rank : 961)	θ value	θ > 10 (rank : 1652)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

CIC_HUMAN
NC score	0.070219 (rank : 962)	θ value	0.0961366 (rank : 840)
Query Neighborhood Hits	1407	Target Neighborhood Hits	992	Shared Neighborhood Hits	337
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DGKH_HUMAN
NC score	0.069990 (rank : 963)	θ value	θ > 10 (rank : 1456)
Query Neighborhood Hits	1407	Target Neighborhood Hits	255	Shared Neighborhood Hits	74
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

IASPP_HUMAN
NC score	0.069875 (rank : 964)	θ value	8.99809 (rank : 1367)
Query Neighborhood Hits	1407	Target Neighborhood Hits	688	Shared Neighborhood Hits	214
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PLCG1_MOUSE
NC score	0.069769 (rank : 965)	θ value	θ > 10 (rank : 1549)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	76
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

WASL_HUMAN
NC score	0.069726 (rank : 966)	θ value	θ > 10 (rank : 1650)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	186
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

UN13A_HUMAN
NC score	0.069655 (rank : 967)	θ value	θ > 10 (rank : 1626)
Query Neighborhood Hits	1407	Target Neighborhood Hits	285	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ZN207_HUMAN
NC score	0.069473 (rank : 968)	θ value	θ > 10 (rank : 1657)
Query Neighborhood Hits	1407	Target Neighborhood Hits	326	Shared Neighborhood Hits	113
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

SHE_MOUSE
NC score	0.069398 (rank : 969)	θ value	θ > 10 (rank : 1591)
Query Neighborhood Hits	1407	Target Neighborhood Hits	169	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

CK024_HUMAN
NC score	0.069393 (rank : 970)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	1407	Target Neighborhood Hits	408	Shared Neighborhood Hits	169
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

PLCG1_HUMAN
NC score	0.069129 (rank : 971)	θ value	θ > 10 (rank : 1548)
Query Neighborhood Hits	1407	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CJ078_MOUSE
NC score	0.069055 (rank : 972)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	1407	Target Neighborhood Hits	559	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

BUB1B_MOUSE
NC score	0.068446 (rank : 973)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

ATX2L_HUMAN
NC score	0.068392 (rank : 974)	θ value	0.0193708 (rank : 799)
Query Neighborhood Hits	1407	Target Neighborhood Hits	443	Shared Neighborhood Hits	179
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

CS016_HUMAN
NC score	0.068364 (rank : 975)	θ value	6.88961 (rank : 1281)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

SHE_HUMAN
NC score	0.068283 (rank : 976)	θ value	θ > 10 (rank : 1590)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PLCG2_HUMAN
NC score	0.068193 (rank : 977)	θ value	θ > 10 (rank : 1550)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	63
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

DGKK_HUMAN
NC score	0.068123 (rank : 978)	θ value	θ > 10 (rank : 1457)
Query Neighborhood Hits	1407	Target Neighborhood Hits	378	Shared Neighborhood Hits	175
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

SF3A2_HUMAN
NC score	0.068116 (rank : 979)	θ value	θ > 10 (rank : 1574)
Query Neighborhood Hits	1407	Target Neighborhood Hits	263	Shared Neighborhood Hits	145
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

MUC1_MOUSE
NC score	0.068063 (rank : 980)	θ value	θ > 10 (rank : 1521)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	113
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

IASPP_MOUSE
NC score	0.068047 (rank : 981)	θ value	θ > 10 (rank : 1488)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1024	Shared Neighborhood Hits	286
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

P85B_MOUSE
NC score	0.067927 (rank : 982)	θ value	θ > 10 (rank : 1540)
Query Neighborhood Hits	1407	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SHAN1_HUMAN
NC score	0.067734 (rank : 983)	θ value	1.38821 (rank : 1037)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1041	Shared Neighborhood Hits	282
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

WBP11_MOUSE
NC score	0.067716 (rank : 984)	θ value	θ > 10 (rank : 1653)
Query Neighborhood Hits	1407	Target Neighborhood Hits	362	Shared Neighborhood Hits	165
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

LCP2_HUMAN
NC score	0.067600 (rank : 985)	θ value	θ > 10 (rank : 1508)
Query Neighborhood Hits	1407	Target Neighborhood Hits	531	Shared Neighborhood Hits	193
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SFPQ_MOUSE
NC score	0.067337 (rank : 986)	θ value	6.88961 (rank : 1320)
Query Neighborhood Hits	1407	Target Neighborhood Hits	958	Shared Neighborhood Hits	276
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

P85B_HUMAN
NC score	0.067332 (rank : 987)	θ value	θ > 10 (rank : 1539)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	108
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

YLPM1_HUMAN
NC score	0.066964 (rank : 988)	θ value	θ > 10 (rank : 1656)
Query Neighborhood Hits	1407	Target Neighborhood Hits	670	Shared Neighborhood Hits	244
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

CCNK_MOUSE
NC score	0.066939 (rank : 989)	θ value	0.0736092 (rank : 832)
Query Neighborhood Hits	1407	Target Neighborhood Hits	350	Shared Neighborhood Hits	189
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CHIO_MOUSE
NC score	0.066499 (rank : 990)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

WIRE_MOUSE
NC score	0.066478 (rank : 991)	θ value	θ > 10 (rank : 1655)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

UN13B_HUMAN
NC score	0.066477 (rank : 992)	θ value	θ > 10 (rank : 1627)
Query Neighborhood Hits	1407	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

P55G_MOUSE
NC score	0.066232 (rank : 993)	θ value	θ > 10 (rank : 1536)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	71
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

NRBP2_MOUSE
NC score	0.066178 (rank : 994)	θ value	θ > 10 (rank : 1532)
Query Neighborhood Hits	1407	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q91V36, Q8R3M0	Gene names	Nrbp2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein 2.

CSKI2_HUMAN
NC score	0.065777 (rank : 995)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	1407	Target Neighborhood Hits	747	Shared Neighborhood Hits	238
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GRB14_MOUSE
NC score	0.065684 (rank : 996)	θ value	θ > 10 (rank : 1473)
Query Neighborhood Hits	1407	Target Neighborhood Hits	149	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ALEX_HUMAN
NC score	0.065679 (rank : 997)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1407	Target Neighborhood Hits	361	Shared Neighborhood Hits	177
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

MLL3_HUMAN
NC score	0.065614 (rank : 998)	θ value	0.00228821 (rank : 743)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1644	Shared Neighborhood Hits	368
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MUC2_HUMAN
NC score	0.064857 (rank : 999)	θ value	2.36792 (rank : 1115)
Query Neighborhood Hits	1407	Target Neighborhood Hits	906	Shared Neighborhood Hits	257
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

BCL9_MOUSE
NC score	0.064606 (rank : 1000)	θ value	3.0926 (rank : 1131)
Query Neighborhood Hits	1407	Target Neighborhood Hits	770	Shared Neighborhood Hits	258
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

P55G_HUMAN
NC score	0.064568 (rank : 1001)	θ value	θ > 10 (rank : 1535)
Query Neighborhood Hits	1407	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

NRBP2_HUMAN
NC score	0.064453 (rank : 1002)	θ value	θ > 10 (rank : 1531)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSY0, Q597G7, Q8NCX8, Q8WYS5	Gene names	NRBP2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein 2 (Transformation-related protein 16).

BASP_MOUSE
NC score	0.064281 (rank : 1003)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	94
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

R3HD2_MOUSE
NC score	0.064193 (rank : 1004)	θ value	0.00509761 (rank : 767)
Query Neighborhood Hits	1407	Target Neighborhood Hits	397	Shared Neighborhood Hits	129
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

ENAH_HUMAN
NC score	0.064113 (rank : 1005)	θ value	0.125558 (rank : 849)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	202
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

SPR1B_MOUSE
NC score	0.064099 (rank : 1006)	θ value	1.99992e-07 (rank : 598)
Query Neighborhood Hits	1407	Target Neighborhood Hits	395	Shared Neighborhood Hits	135
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

BASP_HUMAN
NC score	0.064062 (rank : 1007)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1407	Target Neighborhood Hits	321	Shared Neighborhood Hits	111
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

UN13B_MOUSE
NC score	0.063961 (rank : 1008)	θ value	θ > 10 (rank : 1628)
Query Neighborhood Hits	1407	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CRK_HUMAN
NC score	0.063850 (rank : 1009)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	1407	Target Neighborhood Hits	308	Shared Neighborhood Hits	70
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MINT_MOUSE
NC score	0.063749 (rank : 1010)	θ value	0.0736092 (rank : 834)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1514	Shared Neighborhood Hits	346
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SH24A_HUMAN
NC score	0.063260 (rank : 1011)	θ value	θ > 10 (rank : 1582)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

PO121_HUMAN
NC score	0.063022 (rank : 1012)	θ value	θ > 10 (rank : 1551)
Query Neighborhood Hits	1407	Target Neighborhood Hits	344	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

ASPP1_MOUSE
NC score	0.062912 (rank : 1013)	θ value	2.36792 (rank : 1085)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1244	Shared Neighborhood Hits	272
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DCC_MOUSE
NC score	0.062879 (rank : 1014)	θ value	0.00134147 (rank : 730)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	225
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DGKQ_HUMAN
NC score	0.062532 (rank : 1015)	θ value	θ > 10 (rank : 1458)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	40
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

CRK_MOUSE
NC score	0.062416 (rank : 1016)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	73
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FMN2_HUMAN
NC score	0.062098 (rank : 1017)	θ value	8.99809 (rank : 1356)
Query Neighborhood Hits	1407	Target Neighborhood Hits	484	Shared Neighborhood Hits	201
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

PELP1_MOUSE
NC score	0.061820 (rank : 1018)	θ value	3.0926 (rank : 1150)
Query Neighborhood Hits	1407	Target Neighborhood Hits	709	Shared Neighborhood Hits	230
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

CSKI2_MOUSE
NC score	0.061760 (rank : 1019)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	1407	Target Neighborhood Hits	812	Shared Neighborhood Hits	230
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CIC_MOUSE
NC score	0.061649 (rank : 1020)	θ value	0.21417 (rank : 864)
Query Neighborhood Hits	1407	Target Neighborhood Hits	742	Shared Neighborhood Hits	277
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

APS_HUMAN
NC score	0.061581 (rank : 1021)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	66
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

PRR13_HUMAN
NC score	0.061548 (rank : 1022)	θ value	θ > 10 (rank : 1561)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

MNT_MOUSE
NC score	0.061395 (rank : 1023)	θ value	1.06291 (rank : 991)
Query Neighborhood Hits	1407	Target Neighborhood Hits	432	Shared Neighborhood Hits	171
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

TCOF_MOUSE
NC score	0.061157 (rank : 1024)	θ value	4.03905 (rank : 1202)
Query Neighborhood Hits	1407	Target Neighborhood Hits	471	Shared Neighborhood Hits	137
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SPN90_HUMAN
NC score	0.061127 (rank : 1025)	θ value	θ > 10 (rank : 1597)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

BRD4_MOUSE
NC score	0.061049 (rank : 1026)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1407	Target Neighborhood Hits	845	Shared Neighborhood Hits	277
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

NFH_MOUSE
NC score	0.060977 (rank : 1027)	θ value	1.87187e-05 (rank : 669)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2247	Shared Neighborhood Hits	438
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SFR15_HUMAN
NC score	0.060912 (rank : 1028)	θ value	θ > 10 (rank : 1577)
Query Neighborhood Hits	1407	Target Neighborhood Hits	368	Shared Neighborhood Hits	162
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

ATX2L_MOUSE
NC score	0.060892 (rank : 1029)	θ value	0.0252991 (rank : 804)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	154
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

BAT2_MOUSE
NC score	0.060178 (rank : 1030)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	336
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

GRB14_HUMAN
NC score	0.060170 (rank : 1031)	θ value	θ > 10 (rank : 1472)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SYNJ1_HUMAN
NC score	0.059884 (rank : 1032)	θ value	0.365318 (rank : 916)
Query Neighborhood Hits	1407	Target Neighborhood Hits	498	Shared Neighborhood Hits	229
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

MNT_HUMAN
NC score	0.059758 (rank : 1033)	θ value	1.38821 (rank : 1024)
Query Neighborhood Hits	1407	Target Neighborhood Hits	496	Shared Neighborhood Hits	197
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SET1A_HUMAN
NC score	0.059734 (rank : 1034)	θ value	θ > 10 (rank : 1572)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	228
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

T22D2_HUMAN
NC score	0.059470 (rank : 1035)	θ value	θ > 10 (rank : 1610)
Query Neighborhood Hits	1407	Target Neighborhood Hits	250	Shared Neighborhood Hits	127
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

CO039_MOUSE
NC score	0.059128 (rank : 1036)	θ value	0.279714 (rank : 882)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	190
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

RASF1_HUMAN
NC score	0.059093 (rank : 1037)	θ value	θ > 10 (rank : 1564)
Query Neighborhood Hits	1407	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

DCX_HUMAN
NC score	0.059003 (rank : 1038)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	54
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

PO121_MOUSE
NC score	0.058855 (rank : 1039)	θ value	θ > 10 (rank : 1552)
Query Neighborhood Hits	1407	Target Neighborhood Hits	345	Shared Neighborhood Hits	133
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

MISS_MOUSE
NC score	0.058833 (rank : 1040)	θ value	3.0926 (rank : 1146)
Query Neighborhood Hits	1407	Target Neighborhood Hits	444	Shared Neighborhood Hits	181
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

OSTF1_HUMAN
NC score	0.058819 (rank : 1041)	θ value	θ > 10 (rank : 1533)
Query Neighborhood Hits	1407	Target Neighborhood Hits	466	Shared Neighborhood Hits	77
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SC24C_HUMAN
NC score	0.058768 (rank : 1042)	θ value	0.00869519 (rank : 783)
Query Neighborhood Hits	1407	Target Neighborhood Hits	662	Shared Neighborhood Hits	223
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SPN90_MOUSE
NC score	0.058368 (rank : 1043)	θ value	θ > 10 (rank : 1598)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ITSN1_HUMAN
NC score	0.058362 (rank : 1044)	θ value	0.813845 (rank : 965)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1757	Shared Neighborhood Hits	244
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MAP4_MOUSE
NC score	0.058319 (rank : 1045)	θ value	1.81305 (rank : 1065)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	139
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MLL4_HUMAN
NC score	0.057846 (rank : 1046)	θ value	1.06291 (rank : 990)
Query Neighborhood Hits	1407	Target Neighborhood Hits	722	Shared Neighborhood Hits	259
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NPHP1_MOUSE
NC score	0.057824 (rank : 1047)	θ value	θ > 10 (rank : 1530)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

BRD4_HUMAN
NC score	0.057804 (rank : 1048)	θ value	6.88961 (rank : 1273)
Query Neighborhood Hits	1407	Target Neighborhood Hits	851	Shared Neighborhood Hits	282
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

SHB_MOUSE
NC score	0.057485 (rank : 1049)	θ value	θ > 10 (rank : 1585)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

NCOR2_HUMAN
NC score	0.057342 (rank : 1050)	θ value	θ > 10 (rank : 1526)
Query Neighborhood Hits	1407	Target Neighborhood Hits	870	Shared Neighborhood Hits	255
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PI5PA_MOUSE
NC score	0.057211 (rank : 1051)	θ value	3.0926 (rank : 1151)
Query Neighborhood Hits	1407	Target Neighborhood Hits	331	Shared Neighborhood Hits	167
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

ITSN1_MOUSE
NC score	0.057165 (rank : 1052)	θ value	θ > 10 (rank : 1491)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1669	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TXND2_HUMAN
NC score	0.057138 (rank : 1053)	θ value	1.43324e-05 (rank : 666)
Query Neighborhood Hits	1407	Target Neighborhood Hits	793	Shared Neighborhood Hits	189
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

SELPL_MOUSE
NC score	0.057097 (rank : 1054)	θ value	8.99809 (rank : 1394)
Query Neighborhood Hits	1407	Target Neighborhood Hits	588	Shared Neighborhood Hits	194
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MARCS_HUMAN
NC score	0.057080 (rank : 1055)	θ value	θ > 10 (rank : 1512)
Query Neighborhood Hits	1407	Target Neighborhood Hits	204	Shared Neighborhood Hits	85
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

ALEX_MOUSE
NC score	0.056979 (rank : 1056)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	105
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

MAP4_HUMAN
NC score	0.056971 (rank : 1057)	θ value	0.279714 (rank : 890)
Query Neighborhood Hits	1407	Target Neighborhood Hits	428	Shared Neighborhood Hits	143
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MUC13_MOUSE
NC score	0.056782 (rank : 1058)	θ value	0.813845 (rank : 967)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	118
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

NFRKB_MOUSE
NC score	0.056717 (rank : 1059)	θ value	0.279714 (rank : 892)
Query Neighborhood Hits	1407	Target Neighborhood Hits	393	Shared Neighborhood Hits	150
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

K1802_MOUSE
NC score	0.056593 (rank : 1060)	θ value	1.87187e-05 (rank : 667)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1596	Shared Neighborhood Hits	350
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

K0310_HUMAN
NC score	0.056515 (rank : 1061)	θ value	1.38821 (rank : 1021)
Query Neighborhood Hits	1407	Target Neighborhood Hits	420	Shared Neighborhood Hits	164
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

ARI1A_HUMAN
NC score	0.056421 (rank : 1062)	θ value	8.99809 (rank : 1338)
Query Neighborhood Hits	1407	Target Neighborhood Hits	787	Shared Neighborhood Hits	239
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

GRB7_MOUSE
NC score	0.056387 (rank : 1063)	θ value	θ > 10 (rank : 1477)
Query Neighborhood Hits	1407	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CO002_HUMAN
NC score	0.056176 (rank : 1064)	θ value	0.0148317 (rank : 792)
Query Neighborhood Hits	1407	Target Neighborhood Hits	387	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ASPP1_HUMAN
NC score	0.056072 (rank : 1065)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1407	Target Neighborhood Hits	956	Shared Neighborhood Hits	187
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

LNK_HUMAN
NC score	0.056057 (rank : 1066)	θ value	θ > 10 (rank : 1509)
Query Neighborhood Hits	1407	Target Neighborhood Hits	151	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

NPHP1_HUMAN
NC score	0.055507 (rank : 1067)	θ value	θ > 10 (rank : 1529)
Query Neighborhood Hits	1407	Target Neighborhood Hits	288	Shared Neighborhood Hits	60
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SHC1_HUMAN
NC score	0.055432 (rank : 1068)	θ value	θ > 10 (rank : 1586)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

INVO_MOUSE
NC score	0.055376 (rank : 1069)	θ value	θ > 10 (rank : 1489)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	94
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

SHD_MOUSE
NC score	0.055270 (rank : 1070)	θ value	θ > 10 (rank : 1589)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SNPC4_HUMAN
NC score	0.055234 (rank : 1071)	θ value	1.38821 (rank : 1038)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	192
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

MLL3_MOUSE
NC score	0.055222 (rank : 1072)	θ value	0.62314 (rank : 948)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1399	Shared Neighborhood Hits	323
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

P85A_HUMAN
NC score	0.055141 (rank : 1073)	θ value	θ > 10 (rank : 1537)
Query Neighborhood Hits	1407	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHB_HUMAN
NC score	0.055055 (rank : 1074)	θ value	θ > 10 (rank : 1584)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	51
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CPSF6_MOUSE
NC score	0.054883 (rank : 1075)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	1407	Target Neighborhood Hits	356	Shared Neighborhood Hits	166
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

SYN1_HUMAN
NC score	0.054714 (rank : 1076)	θ value	θ > 10 (rank : 1608)
Query Neighborhood Hits	1407	Target Neighborhood Hits	419	Shared Neighborhood Hits	211
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

ITSN2_HUMAN
NC score	0.054688 (rank : 1077)	θ value	θ > 10 (rank : 1492)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1173	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SHC1_MOUSE
NC score	0.054685 (rank : 1078)	θ value	θ > 10 (rank : 1587)
Query Neighborhood Hits	1407	Target Neighborhood Hits	180	Shared Neighborhood Hits	60
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

DCX_MOUSE
NC score	0.054652 (rank : 1079)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	42
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

OSTF1_MOUSE
NC score	0.054646 (rank : 1080)	θ value	θ > 10 (rank : 1534)
Query Neighborhood Hits	1407	Target Neighborhood Hits	467	Shared Neighborhood Hits	77
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ES8L3_HUMAN
NC score	0.054612 (rank : 1081)	θ value	θ > 10 (rank : 1464)
Query Neighborhood Hits	1407	Target Neighborhood Hits	206	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SHC2_HUMAN
NC score	0.054579 (rank : 1082)	θ value	θ > 10 (rank : 1588)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	58
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

P85A_MOUSE
NC score	0.054418 (rank : 1083)	θ value	θ > 10 (rank : 1538)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	78
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHD_HUMAN
NC score	0.054405 (rank : 1084)	θ value	5.27518 (rank : 1251)
Query Neighborhood Hits	1407	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

TCOF_HUMAN
NC score	0.054267 (rank : 1085)	θ value	0.365318 (rank : 917)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	154
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

NEO1_MOUSE
NC score	0.054217 (rank : 1086)	θ value	θ > 10 (rank : 1528)
Query Neighborhood Hits	1407	Target Neighborhood Hits	523	Shared Neighborhood Hits	103
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

SHAN2_MOUSE
NC score	0.054187 (rank : 1087)	θ value	θ > 10 (rank : 1583)
Query Neighborhood Hits	1407	Target Neighborhood Hits	446	Shared Neighborhood Hits	138
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

CPSF6_HUMAN
NC score	0.053992 (rank : 1088)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	1407	Target Neighborhood Hits	359	Shared Neighborhood Hits	165
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

TCRG1_MOUSE
NC score	0.053960 (rank : 1089)	θ value	θ > 10 (rank : 1612)
Query Neighborhood Hits	1407	Target Neighborhood Hits	947	Shared Neighborhood Hits	198
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

CDN1C_HUMAN
NC score	0.053760 (rank : 1090)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	1407	Target Neighborhood Hits	168	Shared Neighborhood Hits	100
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

ARI1B_HUMAN
NC score	0.053722 (rank : 1091)	θ value	2.36792 (rank : 1083)
Query Neighborhood Hits	1407	Target Neighborhood Hits	567	Shared Neighborhood Hits	189
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CO039_HUMAN
NC score	0.053618 (rank : 1092)	θ value	0.279714 (rank : 881)
Query Neighborhood Hits	1407	Target Neighborhood Hits	264	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

NEO1_HUMAN
NC score	0.053476 (rank : 1093)	θ value	θ > 10 (rank : 1527)
Query Neighborhood Hits	1407	Target Neighborhood Hits	530	Shared Neighborhood Hits	95
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

K1802_HUMAN
NC score	0.053442 (rank : 1094)	θ value	0.21417 (rank : 867)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1378	Shared Neighborhood Hits	321
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MINT_HUMAN
NC score	0.053338 (rank : 1095)	θ value	0.47712 (rank : 928)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1291	Shared Neighborhood Hits	278
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

WASF2_MOUSE
NC score	0.053161 (rank : 1096)	θ value	θ > 10 (rank : 1646)
Query Neighborhood Hits	1407	Target Neighborhood Hits	315	Shared Neighborhood Hits	179
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

FMN1B_MOUSE
NC score	0.052992 (rank : 1097)	θ value	0.0330416 (rank : 815)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	173
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

EFS_MOUSE
NC score	0.052968 (rank : 1098)	θ value	0.365318 (rank : 904)
Query Neighborhood Hits	1407	Target Neighborhood Hits	389	Shared Neighborhood Hits	133
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SPR1A_MOUSE
NC score	0.052911 (rank : 1099)	θ value	0.000121331 (rank : 702)
Query Neighborhood Hits	1407	Target Neighborhood Hits	343	Shared Neighborhood Hits	105
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ASPP2_HUMAN
NC score	0.052580 (rank : 1100)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1156	Shared Neighborhood Hits	217
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ANK2_HUMAN
NC score	0.052548 (rank : 1101)	θ value	0.00509761 (rank : 764)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1615	Shared Neighborhood Hits	320
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

GRIN1_HUMAN
NC score	0.052469 (rank : 1102)	θ value	6.88961 (rank : 1295)
Query Neighborhood Hits	1407	Target Neighborhood Hits	681	Shared Neighborhood Hits	213
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SAPS1_HUMAN
NC score	0.052399 (rank : 1103)	θ value	0.00134147 (rank : 733)
Query Neighborhood Hits	1407	Target Neighborhood Hits	704	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

MARCS_MOUSE
NC score	0.052382 (rank : 1104)	θ value	θ > 10 (rank : 1513)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	89
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

GRB7_HUMAN
NC score	0.052218 (rank : 1105)	θ value	θ > 10 (rank : 1476)
Query Neighborhood Hits	1407	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

MAVS_HUMAN
NC score	0.052214 (rank : 1106)	θ value	θ > 10 (rank : 1514)
Query Neighborhood Hits	1407	Target Neighborhood Hits	271	Shared Neighborhood Hits	117
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

TARA_HUMAN
NC score	0.052005 (rank : 1107)	θ value	6.88961 (rank : 1326)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1626	Shared Neighborhood Hits	311
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

FMNL_HUMAN
NC score	0.051869 (rank : 1108)	θ value	6.88961 (rank : 1290)
Query Neighborhood Hits	1407	Target Neighborhood Hits	529	Shared Neighborhood Hits	203
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

DCP1A_HUMAN
NC score	0.051717 (rank : 1109)	θ value	0.0563607 (rank : 826)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

FMN1A_MOUSE
NC score	0.051683 (rank : 1110)	θ value	0.813845 (rank : 962)
Query Neighborhood Hits	1407	Target Neighborhood Hits	423	Shared Neighborhood Hits	179
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

CNOT3_HUMAN
NC score	0.051509 (rank : 1111)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	1407	Target Neighborhood Hits	425	Shared Neighborhood Hits	133
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNOT3_MOUSE
NC score	0.051328 (rank : 1112)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	1407	Target Neighborhood Hits	504	Shared Neighborhood Hits	143
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CABIN_HUMAN
NC score	0.051195 (rank : 1113)	θ value	0.279714 (rank : 878)
Query Neighborhood Hits	1407	Target Neighborhood Hits	490	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

ATX2_MOUSE
NC score	0.051075 (rank : 1114)	θ value	2.36792 (rank : 1087)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	177
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

HCLS1_MOUSE
NC score	0.050956 (rank : 1115)	θ value	0.00390308 (rank : 755)
Query Neighborhood Hits	1407	Target Neighborhood Hits	329	Shared Neighborhood Hits	104
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN2_MOUSE
NC score	0.050887 (rank : 1116)	θ value	θ > 10 (rank : 1493)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1371	Shared Neighborhood Hits	165
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

WBS14_HUMAN
NC score	0.050865 (rank : 1117)	θ value	4.03905 (rank : 1206)
Query Neighborhood Hits	1407	Target Neighborhood Hits	273	Shared Neighborhood Hits	139
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

FA47A_HUMAN
NC score	0.050804 (rank : 1118)	θ value	1.38821 (rank : 1013)
Query Neighborhood Hits	1407	Target Neighborhood Hits	451	Shared Neighborhood Hits	157
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

MAP1A_HUMAN
NC score	0.050772 (rank : 1119)	θ value	0.21417 (rank : 869)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1626	Shared Neighborhood Hits	300
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

SF01_HUMAN
NC score	0.050759 (rank : 1120)	θ value	θ > 10 (rank : 1573)
Query Neighborhood Hits	1407	Target Neighborhood Hits	287	Shared Neighborhood Hits	152
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SYN1_MOUSE
NC score	0.050501 (rank : 1121)	θ value	θ > 10 (rank : 1609)
Query Neighborhood Hits	1407	Target Neighborhood Hits	363	Shared Neighborhood Hits	187
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

CIZ1_HUMAN
NC score	0.050496 (rank : 1122)	θ value	1.81305 (rank : 1053)
Query Neighborhood Hits	1407	Target Neighborhood Hits	359	Shared Neighborhood Hits	108
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

DCC_HUMAN
NC score	0.050493 (rank : 1123)	θ value	5.27518 (rank : 1222)
Query Neighborhood Hits	1407	Target Neighborhood Hits	583	Shared Neighborhood Hits	123
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

TCRG1_HUMAN
NC score	0.050337 (rank : 1124)	θ value	θ > 10 (rank : 1611)
Query Neighborhood Hits	1407	Target Neighborhood Hits	929	Shared Neighborhood Hits	192
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

EFS_HUMAN
NC score	0.050240 (rank : 1125)	θ value	θ > 10 (rank : 1462)
Query Neighborhood Hits	1407	Target Neighborhood Hits	348	Shared Neighborhood Hits	137
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

TGON2_HUMAN
NC score	0.050204 (rank : 1126)	θ value	8.99809 (rank : 1397)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1037	Shared Neighborhood Hits	223
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

WASF4_HUMAN
NC score	0.050161 (rank : 1127)	θ value	θ > 10 (rank : 1647)
Query Neighborhood Hits	1407	Target Neighborhood Hits	282	Shared Neighborhood Hits	161
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

SMR3A_HUMAN
NC score	0.050050 (rank : 1128)	θ value	θ > 10 (rank : 1596)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

FMN2_MOUSE
NC score	0.049866 (rank : 1129)	θ value	4.03905 (rank : 1177)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	159
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

LR37A_HUMAN
NC score	0.049489 (rank : 1130)	θ value	6.43352e-06 (rank : 659)
Query Neighborhood Hits	1407	Target Neighborhood Hits	720	Shared Neighborhood Hits	194
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

BCAR1_HUMAN
NC score	0.049307 (rank : 1131)	θ value	4.03905 (rank : 1165)
Query Neighborhood Hits	1407	Target Neighborhood Hits	554	Shared Neighborhood Hits	175
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

TENS4_MOUSE
NC score	0.048871 (rank : 1132)	θ value	0.47712 (rank : 934)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

CG1_HUMAN
NC score	0.048714 (rank : 1133)	θ value	0.163984 (rank : 854)
Query Neighborhood Hits	1407	Target Neighborhood Hits	222	Shared Neighborhood Hits	99
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

MILK1_MOUSE
NC score	0.048489 (rank : 1134)	θ value	6.88961 (rank : 1306)
Query Neighborhood Hits	1407	Target Neighborhood Hits	788	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

FA47B_HUMAN
NC score	0.048180 (rank : 1135)	θ value	0.47712 (rank : 926)
Query Neighborhood Hits	1407	Target Neighborhood Hits	431	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

HCLS1_HUMAN
NC score	0.048018 (rank : 1136)	θ value	2.36792 (rank : 1107)
Query Neighborhood Hits	1407	Target Neighborhood Hits	358	Shared Neighborhood Hits	118
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

BCAR1_MOUSE
NC score	0.046663 (rank : 1137)	θ value	6.88961 (rank : 1270)
Query Neighborhood Hits	1407	Target Neighborhood Hits	438	Shared Neighborhood Hits	163
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

DSCL1_HUMAN
NC score	0.046623 (rank : 1138)	θ value	1.81305 (rank : 1058)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

LPP_HUMAN
NC score	0.046298 (rank : 1139)	θ value	0.62314 (rank : 947)
Query Neighborhood Hits	1407	Target Neighborhood Hits	775	Shared Neighborhood Hits	226
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

CS007_MOUSE
NC score	0.045713 (rank : 1140)	θ value	2.36792 (rank : 1099)
Query Neighborhood Hits	1407	Target Neighborhood Hits	464	Shared Neighborhood Hits	158
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

BAG3_HUMAN
NC score	0.045701 (rank : 1141)	θ value	5.27518 (rank : 1212)
Query Neighborhood Hits	1407	Target Neighborhood Hits	314	Shared Neighborhood Hits	136
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

DIDO1_HUMAN
NC score	0.045482 (rank : 1142)	θ value	0.0431538 (rank : 822)
Query Neighborhood Hits	1407	Target Neighborhood Hits	960	Shared Neighborhood Hits	253
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

RIMB1_HUMAN
NC score	0.044986 (rank : 1143)	θ value	6.88961 (rank : 1317)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1479	Shared Neighborhood Hits	263
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

BAG3_MOUSE
NC score	0.044968 (rank : 1144)	θ value	0.365318 (rank : 898)
Query Neighborhood Hits	1407	Target Neighborhood Hits	513	Shared Neighborhood Hits	181
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CRSP2_HUMAN
NC score	0.044866 (rank : 1145)	θ value	1.38821 (rank : 1009)
Query Neighborhood Hits	1407	Target Neighborhood Hits	380	Shared Neighborhood Hits	142
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

BAZ2A_MOUSE
NC score	0.044011 (rank : 1146)	θ value	0.62314 (rank : 940)
Query Neighborhood Hits	1407	Target Neighborhood Hits	744	Shared Neighborhood Hits	205
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

TULP4_HUMAN
NC score	0.043992 (rank : 1147)	θ value	0.00175202 (rank : 739)
Query Neighborhood Hits	1407	Target Neighborhood Hits	426	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TAU_MOUSE
NC score	0.043955 (rank : 1148)	θ value	4.03905 (rank : 1201)
Query Neighborhood Hits	1407	Target Neighborhood Hits	502	Shared Neighborhood Hits	182
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MUCDL_HUMAN
NC score	0.043401 (rank : 1149)	θ value	1.38821 (rank : 1026)
Query Neighborhood Hits	1407	Target Neighborhood Hits	777	Shared Neighborhood Hits	225
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PSL1_HUMAN
NC score	0.042862 (rank : 1150)	θ value	0.0330416 (rank : 819)
Query Neighborhood Hits	1407	Target Neighborhood Hits	650	Shared Neighborhood Hits	195
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

CD248_HUMAN
NC score	0.042730 (rank : 1151)	θ value	5.44631e-05 (rank : 683)
Query Neighborhood Hits	1407	Target Neighborhood Hits	679	Shared Neighborhood Hits	179
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

TP53B_MOUSE
NC score	0.042573 (rank : 1152)	θ value	1.81305 (rank : 1080)
Query Neighborhood Hits	1407	Target Neighborhood Hits	644	Shared Neighborhood Hits	166
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

SC24A_MOUSE
NC score	0.042558 (rank : 1153)	θ value	1.06291 (rank : 997)
Query Neighborhood Hits	1407	Target Neighborhood Hits	394	Shared Neighborhood Hits	143
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

K1543_HUMAN
NC score	0.042550 (rank : 1154)	θ value	1.38821 (rank : 1022)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

SH22A_MOUSE
NC score	0.042524 (rank : 1155)	θ value	0.62314 (rank : 950)
Query Neighborhood Hits	1407	Target Neighborhood Hits	179	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SDK2_MOUSE
NC score	0.042335 (rank : 1156)	θ value	8.99809 (rank : 1393)
Query Neighborhood Hits	1407	Target Neighborhood Hits	480	Shared Neighborhood Hits	88
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

GRIN1_MOUSE
NC score	0.042213 (rank : 1157)	θ value	1.38821 (rank : 1017)
Query Neighborhood Hits	1407	Target Neighborhood Hits	337	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

EMSY_HUMAN
NC score	0.042116 (rank : 1158)	θ value	2.36792 (rank : 1103)
Query Neighborhood Hits	1407	Target Neighborhood Hits	296	Shared Neighborhood Hits	94
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

MUC5B_HUMAN
NC score	0.042110 (rank : 1159)	θ value	1.38821 (rank : 1025)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1020	Shared Neighborhood Hits	216
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

BAT3_MOUSE
NC score	0.041861 (rank : 1160)	θ value	8.99809 (rank : 1342)
Query Neighborhood Hits	1407	Target Neighborhood Hits	518	Shared Neighborhood Hits	185
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

MKL1_MOUSE
NC score	0.041836 (rank : 1161)	θ value	1.06291 (rank : 989)
Query Neighborhood Hits	1407	Target Neighborhood Hits	667	Shared Neighborhood Hits	212
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

PHC2_HUMAN
NC score	0.041429 (rank : 1162)	θ value	0.0148317 (rank : 796)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	147
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

IF35_MOUSE
NC score	0.040710 (rank : 1163)	θ value	4.03905 (rank : 1180)
Query Neighborhood Hits	1407	Target Neighborhood Hits	210	Shared Neighborhood Hits	111
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

RTP3_MOUSE
NC score	0.040687 (rank : 1164)	θ value	3.0926 (rank : 1153)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	141
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

CI079_HUMAN
NC score	0.040223 (rank : 1165)	θ value	0.813845 (rank : 959)
Query Neighborhood Hits	1407	Target Neighborhood Hits	288	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

ARID2_HUMAN
NC score	0.040190 (rank : 1166)	θ value	2.36792 (rank : 1084)
Query Neighborhood Hits	1407	Target Neighborhood Hits	302	Shared Neighborhood Hits	90
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

EP400_HUMAN
NC score	0.040166 (rank : 1167)	θ value	2.36792 (rank : 1104)
Query Neighborhood Hits	1407	Target Neighborhood Hits	556	Shared Neighborhood Hits	217
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

BPTF_HUMAN
NC score	0.039967 (rank : 1168)	θ value	6.88961 (rank : 1272)
Query Neighborhood Hits	1407	Target Neighborhood Hits	786	Shared Neighborhood Hits	179
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

ANKS1_MOUSE
NC score	0.039944 (rank : 1169)	θ value	0.813845 (rank : 956)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	85
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

BAZ2A_HUMAN
NC score	0.039816 (rank : 1170)	θ value	0.0113563 (rank : 787)
Query Neighborhood Hits	1407	Target Neighborhood Hits	780	Shared Neighborhood Hits	192
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

MTSS1_HUMAN
NC score	0.039599 (rank : 1171)	θ value	1.81305 (rank : 1067)
Query Neighborhood Hits	1407	Target Neighborhood Hits	504	Shared Neighborhood Hits	131
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

CCD45_MOUSE
NC score	0.039531 (rank : 1172)	θ value	1.06291 (rank : 979)
Query Neighborhood Hits	1407	Target Neighborhood Hits	663	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

EP400_MOUSE
NC score	0.039378 (rank : 1173)	θ value	0.813845 (rank : 961)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	219
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MTSS1_MOUSE
NC score	0.039226 (rank : 1174)	θ value	3.0926 (rank : 1147)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	176
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

IRS2_HUMAN
NC score	0.038549 (rank : 1175)	θ value	8.99809 (rank : 1369)
Query Neighborhood Hits	1407	Target Neighborhood Hits	262	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

CS007_HUMAN
NC score	0.038307 (rank : 1176)	θ value	3.0926 (rank : 1137)
Query Neighborhood Hits	1407	Target Neighborhood Hits	401	Shared Neighborhood Hits	138
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

LAD1_MOUSE
NC score	0.038178 (rank : 1177)	θ value	1.06291 (rank : 987)
Query Neighborhood Hits	1407	Target Neighborhood Hits	391	Shared Neighborhood Hits	113
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PER2_MOUSE
NC score	0.037945 (rank : 1178)	θ value	1.87187e-05 (rank : 670)
Query Neighborhood Hits	1407	Target Neighborhood Hits	325	Shared Neighborhood Hits	108
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

3BP1_HUMAN
NC score	0.037814 (rank : 1179)	θ value	0.47712 (rank : 919)
Query Neighborhood Hits	1407	Target Neighborhood Hits	376	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ZN645_HUMAN
NC score	0.037721 (rank : 1180)	θ value	0.0961366 (rank : 847)
Query Neighborhood Hits	1407	Target Neighborhood Hits	265	Shared Neighborhood Hits	85
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

AMOT_HUMAN
NC score	0.037629 (rank : 1181)	θ value	5.27518 (rank : 1208)
Query Neighborhood Hits	1407	Target Neighborhood Hits	712	Shared Neighborhood Hits	156
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

OBF1_HUMAN
NC score	0.037586 (rank : 1182)	θ value	1.06291 (rank : 993)
Query Neighborhood Hits	1407	Target Neighborhood Hits	203	Shared Neighborhood Hits	103
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

SSBP4_HUMAN
NC score	0.037154 (rank : 1183)	θ value	0.0252991 (rank : 810)
Query Neighborhood Hits	1407	Target Neighborhood Hits	753	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SYNPO_HUMAN
NC score	0.037053 (rank : 1184)	θ value	6.88961 (rank : 1325)
Query Neighborhood Hits	1407	Target Neighborhood Hits	281	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

SRBP1_HUMAN
NC score	0.036866 (rank : 1185)	θ value	8.99809 (rank : 1396)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	93
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

PTN23_MOUSE
NC score	0.036811 (rank : 1186)	θ value	0.279714 (rank : 896)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	265
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

FYB_HUMAN
NC score	0.036722 (rank : 1187)	θ value	8.99809 (rank : 1361)
Query Neighborhood Hits	1407	Target Neighborhood Hits	379	Shared Neighborhood Hits	124
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

BAT3_HUMAN
NC score	0.036423 (rank : 1188)	θ value	8.99809 (rank : 1341)
Query Neighborhood Hits	1407	Target Neighborhood Hits	490	Shared Neighborhood Hits	163
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SRBS1_MOUSE
NC score	0.036277 (rank : 1189)	θ value	5.27518 (rank : 1255)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	104
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

IWS1_MOUSE
NC score	0.035922 (rank : 1190)	θ value	0.0563607 (rank : 828)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1258	Shared Neighborhood Hits	216
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SH23A_HUMAN
NC score	0.035896 (rank : 1191)	θ value	6.88961 (rank : 1321)
Query Neighborhood Hits	1407	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

ANR11_HUMAN
NC score	0.035844 (rank : 1192)	θ value	5.27518 (rank : 1209)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1289	Shared Neighborhood Hits	209
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

RIN3_HUMAN
NC score	0.035688 (rank : 1193)	θ value	6.88961 (rank : 1318)
Query Neighborhood Hits	1407	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

APXL_HUMAN
NC score	0.035518 (rank : 1194)	θ value	0.365318 (rank : 897)
Query Neighborhood Hits	1407	Target Neighborhood Hits	553	Shared Neighborhood Hits	134
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CEL_HUMAN
NC score	0.035449 (rank : 1195)	θ value	0.279714 (rank : 879)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	265
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

BRD8_MOUSE
NC score	0.035359 (rank : 1196)	θ value	0.365318 (rank : 900)
Query Neighborhood Hits	1407	Target Neighborhood Hits	422	Shared Neighborhood Hits	108
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

FMNL_MOUSE
NC score	0.035236 (rank : 1197)	θ value	8.99809 (rank : 1357)
Query Neighborhood Hits	1407	Target Neighborhood Hits	428	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

TROAP_HUMAN
NC score	0.034993 (rank : 1198)	θ value	8.99809 (rank : 1400)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	104
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

JPH2_HUMAN
NC score	0.034775 (rank : 1199)	θ value	0.21417 (rank : 866)
Query Neighborhood Hits	1407	Target Neighborhood Hits	639	Shared Neighborhood Hits	202
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

SMOO_HUMAN
NC score	0.034727 (rank : 1200)	θ value	3.0926 (rank : 1155)
Query Neighborhood Hits	1407	Target Neighborhood Hits	391	Shared Neighborhood Hits	150
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

ZN598_HUMAN
NC score	0.034318 (rank : 1201)	θ value	1.81305 (rank : 1081)
Query Neighborhood Hits	1407	Target Neighborhood Hits	339	Shared Neighborhood Hits	97
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

GA2L2_MOUSE
NC score	0.034264 (rank : 1202)	θ value	0.279714 (rank : 885)
Query Neighborhood Hits	1407	Target Neighborhood Hits	395	Shared Neighborhood Hits	133
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

SPR1A_HUMAN
NC score	0.034208 (rank : 1203)	θ value	0.365318 (rank : 915)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

MYO15_HUMAN
NC score	0.034150 (rank : 1204)	θ value	0.0961366 (rank : 843)
Query Neighborhood Hits	1407	Target Neighborhood Hits	671	Shared Neighborhood Hits	213
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PUNC_MOUSE
NC score	0.034109 (rank : 1205)	θ value	1.81305 (rank : 1074)
Query Neighborhood Hits	1407	Target Neighborhood Hits	501	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ZAR1_HUMAN
NC score	0.033932 (rank : 1206)	θ value	0.21417 (rank : 876)
Query Neighborhood Hits	1407	Target Neighborhood Hits	163	Shared Neighborhood Hits	51
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZIMP7_MOUSE
NC score	0.033883 (rank : 1207)	θ value	2.36792 (rank : 1130)
Query Neighborhood Hits	1407	Target Neighborhood Hits	566	Shared Neighborhood Hits	183
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

SETBP_HUMAN
NC score	0.033845 (rank : 1208)	θ value	1.38821 (rank : 1036)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

DIAP1_HUMAN
NC score	0.033545 (rank : 1209)	θ value	8.99809 (rank : 1353)
Query Neighborhood Hits	1407	Target Neighborhood Hits	784	Shared Neighborhood Hits	188
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

SEPT9_HUMAN
NC score	0.033479 (rank : 1210)	θ value	0.00509761 (rank : 768)
Query Neighborhood Hits	1407	Target Neighborhood Hits	706	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

CD008_HUMAN
NC score	0.033216 (rank : 1211)	θ value	6.88961 (rank : 1275)
Query Neighborhood Hits	1407	Target Neighborhood Hits	330	Shared Neighborhood Hits	83
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

MYO15_MOUSE
NC score	0.033140 (rank : 1212)	θ value	0.000158464 (rank : 704)
Query Neighborhood Hits	1407	Target Neighborhood Hits	467	Shared Neighborhood Hits	144
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PHLB1_HUMAN
NC score	0.032866 (rank : 1213)	θ value	5.27518 (rank : 1244)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1038	Shared Neighborhood Hits	206
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SYNPO_MOUSE
NC score	0.032768 (rank : 1214)	θ value	0.47712 (rank : 933)
Query Neighborhood Hits	1407	Target Neighborhood Hits	242	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

ZYX_HUMAN
NC score	0.032750 (rank : 1215)	θ value	3.0926 (rank : 1164)
Query Neighborhood Hits	1407	Target Neighborhood Hits	387	Shared Neighborhood Hits	128
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ZN385_HUMAN
NC score	0.032709 (rank : 1216)	θ value	0.47712 (rank : 938)
Query Neighborhood Hits	1407	Target Neighborhood Hits	614	Shared Neighborhood Hits	168
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

IWS1_HUMAN
NC score	0.032488 (rank : 1217)	θ value	5.27518 (rank : 1232)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1241	Shared Neighborhood Hits	199
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TCGAP_HUMAN
NC score	0.032474 (rank : 1218)	θ value	0.00228821 (rank : 745)
Query Neighborhood Hits	1407	Target Neighborhood Hits	872	Shared Neighborhood Hits	246
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ZIM10_HUMAN
NC score	0.032331 (rank : 1219)	θ value	0.00869519 (rank : 786)
Query Neighborhood Hits	1407	Target Neighborhood Hits	577	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

SRBP1_MOUSE
NC score	0.032254 (rank : 1220)	θ value	1.81305 (rank : 1079)
Query Neighborhood Hits	1407	Target Neighborhood Hits	384	Shared Neighborhood Hits	141
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

OGFR_MOUSE
NC score	0.032143 (rank : 1221)	θ value	2.36792 (rank : 1117)
Query Neighborhood Hits	1407	Target Neighborhood Hits	584	Shared Neighborhood Hits	137
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

CECR2_HUMAN
NC score	0.031977 (rank : 1222)	θ value	0.0961366 (rank : 839)
Query Neighborhood Hits	1407	Target Neighborhood Hits	543	Shared Neighborhood Hits	153
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

HCFC1_HUMAN
NC score	0.031878 (rank : 1223)	θ value	6.88961 (rank : 1296)
Query Neighborhood Hits	1407	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

EPN3_MOUSE
NC score	0.031812 (rank : 1224)	θ value	0.0961366 (rank : 842)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	120
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ATX7_HUMAN
NC score	0.031607 (rank : 1225)	θ value	0.163984 (rank : 853)
Query Neighborhood Hits	1407	Target Neighborhood Hits	351	Shared Neighborhood Hits	104
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

KI67_HUMAN
NC score	0.031589 (rank : 1226)	θ value	2.36792 (rank : 1113)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	107
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

PLCB4_HUMAN
NC score	0.031586 (rank : 1227)	θ value	2.36792 (rank : 1119)
Query Neighborhood Hits	1407	Target Neighborhood Hits	658	Shared Neighborhood Hits	82
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

TRI66_HUMAN
NC score	0.031541 (rank : 1228)	θ value	3.0926 (rank : 1160)
Query Neighborhood Hits	1407	Target Neighborhood Hits	479	Shared Neighborhood Hits	139
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ZYX_MOUSE
NC score	0.031478 (rank : 1229)	θ value	8.99809 (rank : 1407)
Query Neighborhood Hits	1407	Target Neighborhood Hits	347	Shared Neighborhood Hits	111
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

IER5_MOUSE
NC score	0.031422 (rank : 1230)	θ value	0.365318 (rank : 910)
Query Neighborhood Hits	1407	Target Neighborhood Hits	110	Shared Neighborhood Hits	47
SwissProt Accessions	O89113, Q8CGI0	Gene names	Ier5
Domain Architecture	No domain graphic available
Description	Immediate early response gene 5 protein.

NUMBL_HUMAN
NC score	0.031419 (rank : 1231)	θ value	0.0330416 (rank : 818)
Query Neighborhood Hits	1407	Target Neighborhood Hits	394	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

IL3B2_MOUSE
NC score	0.031357 (rank : 1232)	θ value	2.36792 (rank : 1110)
Query Neighborhood Hits	1407	Target Neighborhood Hits	372	Shared Neighborhood Hits	132
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

K0586_HUMAN
NC score	0.031284 (rank : 1233)	θ value	5.27518 (rank : 1233)
Query Neighborhood Hits	1407	Target Neighborhood Hits	311	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

CASL_HUMAN
NC score	0.030888 (rank : 1234)	θ value	0.0148317 (rank : 791)
Query Neighborhood Hits	1407	Target Neighborhood Hits	259	Shared Neighborhood Hits	63
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

IF4G1_MOUSE
NC score	0.030684 (rank : 1235)	θ value	1.38821 (rank : 1019)
Query Neighborhood Hits	1407	Target Neighborhood Hits	534	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

TRI66_MOUSE
NC score	0.030596 (rank : 1236)	θ value	0.0252991 (rank : 811)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	139
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

SOX13_MOUSE
NC score	0.030345 (rank : 1237)	θ value	0.0252991 (rank : 809)
Query Neighborhood Hits	1407	Target Neighborhood Hits	495	Shared Neighborhood Hits	143
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

GON4L_MOUSE
NC score	0.030237 (rank : 1238)	θ value	0.0431538 (rank : 823)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	112
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

IQEC2_MOUSE
NC score	0.030127 (rank : 1239)	θ value	1.81305 (rank : 1063)
Query Neighborhood Hits	1407	Target Neighborhood Hits	417	Shared Neighborhood Hits	152
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

NRX2B_HUMAN
NC score	0.030057 (rank : 1240)	θ value	0.00390308 (rank : 762)
Query Neighborhood Hits	1407	Target Neighborhood Hits	481	Shared Neighborhood Hits	144
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

AFF4_HUMAN
NC score	0.030036 (rank : 1241)	θ value	1.81305 (rank : 1046)
Query Neighborhood Hits	1407	Target Neighborhood Hits	611	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

TPO_MOUSE
NC score	0.029950 (rank : 1242)	θ value	0.0431538 (rank : 825)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

IQEC2_HUMAN
NC score	0.029917 (rank : 1243)	θ value	1.38821 (rank : 1020)
Query Neighborhood Hits	1407	Target Neighborhood Hits	403	Shared Neighborhood Hits	149
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

CSF1_HUMAN
NC score	0.029633 (rank : 1244)	θ value	8.99809 (rank : 1350)
Query Neighborhood Hits	1407	Target Neighborhood Hits	258	Shared Neighborhood Hits	94
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

ARMX2_MOUSE
NC score	0.029555 (rank : 1245)	θ value	0.279714 (rank : 877)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	129
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

CD248_MOUSE
NC score	0.029417 (rank : 1246)	θ value	0.00035302 (rank : 716)
Query Neighborhood Hits	1407	Target Neighborhood Hits	578	Shared Neighborhood Hits	142
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

NSD1_MOUSE
NC score	0.029363 (rank : 1247)	θ value	0.0563607 (rank : 829)
Query Neighborhood Hits	1407	Target Neighborhood Hits	472	Shared Neighborhood Hits	109
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

IL3RB_MOUSE
NC score	0.029342 (rank : 1248)	θ value	2.36792 (rank : 1111)
Query Neighborhood Hits	1407	Target Neighborhood Hits	355	Shared Neighborhood Hits	121
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

SETBP_MOUSE
NC score	0.029185 (rank : 1249)	θ value	2.36792 (rank : 1123)
Query Neighborhood Hits	1407	Target Neighborhood Hits	352	Shared Neighborhood Hits	117
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

TXLNA_HUMAN
NC score	0.029170 (rank : 1250)	θ value	0.62314 (rank : 952)
Query Neighborhood Hits	1407	Target Neighborhood Hits	982	Shared Neighborhood Hits	126
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

INVS_MOUSE
NC score	0.029132 (rank : 1251)	θ value	1.06291 (rank : 986)
Query Neighborhood Hits	1407	Target Neighborhood Hits	609	Shared Neighborhood Hits	127
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

RP3A_MOUSE
NC score	0.029030 (rank : 1252)	θ value	1.38821 (rank : 1034)
Query Neighborhood Hits	1407	Target Neighborhood Hits	510	Shared Neighborhood Hits	153
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

NPAS4_MOUSE
NC score	0.028996 (rank : 1253)	θ value	2.36792 (rank : 1116)
Query Neighborhood Hits	1407	Target Neighborhood Hits	245	Shared Neighborhood Hits	87
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

DOK2_MOUSE
NC score	0.028851 (rank : 1254)	θ value	0.0252991 (rank : 806)
Query Neighborhood Hits	1407	Target Neighborhood Hits	244	Shared Neighborhood Hits	83
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

SFR16_MOUSE
NC score	0.028296 (rank : 1255)	θ value	0.813845 (rank : 972)
Query Neighborhood Hits	1407	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

RP3A_HUMAN
NC score	0.028279 (rank : 1256)	θ value	1.38821 (rank : 1033)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

GNAS1_MOUSE
NC score	0.028247 (rank : 1257)	θ value	0.000461057 (rank : 722)
Query Neighborhood Hits	1407	Target Neighborhood Hits	651	Shared Neighborhood Hits	196
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SOX30_HUMAN
NC score	0.028159 (rank : 1258)	θ value	0.00665767 (rank : 775)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	104
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

PF21B_MOUSE
NC score	0.027797 (rank : 1259)	θ value	6.88961 (rank : 1310)
Query Neighborhood Hits	1407	Target Neighborhood Hits	278	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

SPR1B_HUMAN
NC score	0.027730 (rank : 1260)	θ value	5.27518 (rank : 1254)
Query Neighborhood Hits	1407	Target Neighborhood Hits	102	Shared Neighborhood Hits	26
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

AFF4_MOUSE
NC score	0.027659 (rank : 1261)	θ value	0.163984 (rank : 852)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	110
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

IQEC3_MOUSE
NC score	0.027652 (rank : 1262)	θ value	0.0193708 (rank : 801)
Query Neighborhood Hits	1407	Target Neighborhood Hits	274	Shared Neighborhood Hits	116
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

HCN2_HUMAN
NC score	0.027601 (rank : 1263)	θ value	0.279714 (rank : 886)
Query Neighborhood Hits	1407	Target Neighborhood Hits	369	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

TGON2_MOUSE
NC score	0.027575 (rank : 1264)	θ value	8.99809 (rank : 1398)
Query Neighborhood Hits	1407	Target Neighborhood Hits	277	Shared Neighborhood Hits	62
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

TULP4_MOUSE
NC score	0.027550 (rank : 1265)	θ value	0.62314 (rank : 951)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

CSPG5_HUMAN
NC score	0.027494 (rank : 1266)	θ value	0.279714 (rank : 884)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	76
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

HGS_MOUSE
NC score	0.027258 (rank : 1267)	θ value	1.81305 (rank : 1061)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	157
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SOX13_HUMAN
NC score	0.027242 (rank : 1268)	θ value	0.0252991 (rank : 808)
Query Neighborhood Hits	1407	Target Neighborhood Hits	464	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

DDEF1_MOUSE
NC score	0.026758 (rank : 1269)	θ value	0.00665767 (rank : 772)
Query Neighborhood Hits	1407	Target Neighborhood Hits	592	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MEGF9_MOUSE
NC score	0.026303 (rank : 1270)	θ value	3.0926 (rank : 1145)
Query Neighborhood Hits	1407	Target Neighborhood Hits	896	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

COIA1_HUMAN
NC score	0.026252 (rank : 1271)	θ value	2.36792 (rank : 1097)
Query Neighborhood Hits	1407	Target Neighborhood Hits	447	Shared Neighborhood Hits	157
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CGRE1_HUMAN
NC score	0.025899 (rank : 1272)	θ value	0.0252991 (rank : 805)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	77
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

RUSC2_MOUSE
NC score	0.025895 (rank : 1273)	θ value	1.81305 (rank : 1076)
Query Neighborhood Hits	1407	Target Neighborhood Hits	305	Shared Neighborhood Hits	112
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

PDZD2_HUMAN
NC score	0.025873 (rank : 1274)	θ value	5.27518 (rank : 1243)
Query Neighborhood Hits	1407	Target Neighborhood Hits	772	Shared Neighborhood Hits	186
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

ZAR1_MOUSE
NC score	0.025761 (rank : 1275)	θ value	3.0926 (rank : 1162)
Query Neighborhood Hits	1407	Target Neighborhood Hits	254	Shared Neighborhood Hits	66
SwissProt Accessions	Q80SU3	Gene names	Zar1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

CO3A1_MOUSE
NC score	0.025759 (rank : 1276)	θ value	2.36792 (rank : 1093)
Query Neighborhood Hits	1407	Target Neighborhood Hits	466	Shared Neighborhood Hits	134
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

EHMT2_MOUSE
NC score	0.025751 (rank : 1277)	θ value	0.365318 (rank : 905)
Query Neighborhood Hits	1407	Target Neighborhood Hits	750	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

CSPG5_MOUSE
NC score	0.025652 (rank : 1278)	θ value	0.813845 (rank : 960)
Query Neighborhood Hits	1407	Target Neighborhood Hits	211	Shared Neighborhood Hits	68
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

DAB1_HUMAN
NC score	0.025564 (rank : 1279)	θ value	0.365318 (rank : 903)
Query Neighborhood Hits	1407	Target Neighborhood Hits	219	Shared Neighborhood Hits	81
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

ZIM10_MOUSE
NC score	0.025514 (rank : 1280)	θ value	0.365318 (rank : 918)
Query Neighborhood Hits	1407	Target Neighborhood Hits	430	Shared Neighborhood Hits	136
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ELF4_MOUSE
NC score	0.025230 (rank : 1281)	θ value	0.00665767 (rank : 773)
Query Neighborhood Hits	1407	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z2U4	Gene names	Elf4, Mef
Domain Architecture	No domain graphic available
Description	ETS-related transcription factor Elf-4 (E74-like factor 4) (Myeloid Elf-1-like factor).

MEGF9_HUMAN
NC score	0.025191 (rank : 1282)	θ value	0.0148317 (rank : 794)
Query Neighborhood Hits	1407	Target Neighborhood Hits	557	Shared Neighborhood Hits	149
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

SNPC4_MOUSE
NC score	0.025096 (rank : 1283)	θ value	0.47712 (rank : 931)
Query Neighborhood Hits	1407	Target Neighborhood Hits	237	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

DAB2_HUMAN
NC score	0.024848 (rank : 1284)	θ value	0.125558 (rank : 848)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	70
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

EVL_HUMAN
NC score	0.024719 (rank : 1285)	θ value	3.0926 (rank : 1140)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

APC_MOUSE
NC score	0.024712 (rank : 1286)	θ value	6.88961 (rank : 1267)
Query Neighborhood Hits	1407	Target Neighborhood Hits	441	Shared Neighborhood Hits	100
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

BTBDC_HUMAN
NC score	0.024126 (rank : 1287)	θ value	3.0926 (rank : 1132)
Query Neighborhood Hits	1407	Target Neighborhood Hits	248	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CIKS_HUMAN
NC score	0.023791 (rank : 1288)	θ value	0.365318 (rank : 902)
Query Neighborhood Hits	1407	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CJ108_HUMAN
NC score	0.023678 (rank : 1289)	θ value	5.27518 (rank : 1216)
Query Neighborhood Hits	1407	Target Neighborhood Hits	165	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

AIM1_HUMAN
NC score	0.023641 (rank : 1290)	θ value	0.47712 (rank : 920)
Query Neighborhood Hits	1407	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

LIMD1_MOUSE
NC score	0.023604 (rank : 1291)	θ value	0.163984 (rank : 857)
Query Neighborhood Hits	1407	Target Neighborhood Hits	291	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

CDN1C_MOUSE
NC score	0.023603 (rank : 1292)	θ value	2.36792 (rank : 1091)
Query Neighborhood Hits	1407	Target Neighborhood Hits	161	Shared Neighborhood Hits	53
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

MAVS_MOUSE
NC score	0.023372 (rank : 1293)	θ value	4.03905 (rank : 1185)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

PDLI7_HUMAN
NC score	0.023309 (rank : 1294)	θ value	0.00298849 (rank : 748)
Query Neighborhood Hits	1407	Target Neighborhood Hits	547	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

JADE2_MOUSE
NC score	0.023284 (rank : 1295)	θ value	8.99809 (rank : 1370)
Query Neighborhood Hits	1407	Target Neighborhood Hits	560	Shared Neighborhood Hits	177
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

HSF1_MOUSE
NC score	0.022842 (rank : 1296)	θ value	1.38821 (rank : 1018)
Query Neighborhood Hits	1407	Target Neighborhood Hits	267	Shared Neighborhood Hits	91
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

BCL3_MOUSE
NC score	0.022742 (rank : 1297)	θ value	0.00390308 (rank : 752)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

RFIP3_HUMAN
NC score	0.022736 (rank : 1298)	θ value	6.88961 (rank : 1314)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1055	Shared Neighborhood Hits	155
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

MD1L1_HUMAN
NC score	0.022532 (rank : 1299)	θ value	1.06291 (rank : 988)
Query Neighborhood Hits	1407	Target Neighborhood Hits	893	Shared Neighborhood Hits	81
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MEF2B_HUMAN
NC score	0.022522 (rank : 1300)	θ value	0.279714 (rank : 891)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	71
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

SYNP2_HUMAN
NC score	0.022249 (rank : 1301)	θ value	2.36792 (rank : 1125)
Query Neighborhood Hits	1407	Target Neighborhood Hits	323	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

CO7A1_HUMAN
NC score	0.022199 (rank : 1302)	θ value	2.36792 (rank : 1094)
Query Neighborhood Hits	1407	Target Neighborhood Hits	807	Shared Neighborhood Hits	196
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CT055_MOUSE
NC score	0.022134 (rank : 1303)	θ value	1.81305 (rank : 1056)
Query Neighborhood Hits	1407	Target Neighborhood Hits	52	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R184, Q8BQE5, Q8K024, Q8VEM7, Q9CU80	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf55 homolog.

AFF2_MOUSE
NC score	0.022116 (rank : 1304)	θ value	6.88961 (rank : 1266)
Query Neighborhood Hits	1407	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

RBCC1_HUMAN
NC score	0.022037 (rank : 1305)	θ value	8.99809 (rank : 1392)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1023	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

NUP53_MOUSE
NC score	0.021950 (rank : 1306)	θ value	0.47712 (rank : 929)
Query Neighborhood Hits	1407	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

NUP53_HUMAN
NC score	0.021697 (rank : 1307)	θ value	1.81305 (rank : 1068)
Query Neighborhood Hits	1407	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

ASTL_HUMAN
NC score	0.021658 (rank : 1308)	θ value	1.38821 (rank : 1005)
Query Neighborhood Hits	1407	Target Neighborhood Hits	252	Shared Neighborhood Hits	97
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

TACC3_HUMAN
NC score	0.021268 (rank : 1309)	θ value	1.38821 (rank : 1040)
Query Neighborhood Hits	1407	Target Neighborhood Hits	779	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

HPS4_MOUSE
NC score	0.021166 (rank : 1310)	θ value	3.0926 (rank : 1142)
Query Neighborhood Hits	1407	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q99KG7	Gene names	Hps4, Le
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein homolog (Light-ear protein) (Le protein).

CN004_HUMAN
NC score	0.021149 (rank : 1311)	θ value	2.36792 (rank : 1092)
Query Neighborhood Hits	1407	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

LARP4_MOUSE
NC score	0.021145 (rank : 1312)	θ value	4.03905 (rank : 1183)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

GNDS_HUMAN
NC score	0.021000 (rank : 1313)	θ value	3.0926 (rank : 1141)
Query Neighborhood Hits	1407	Target Neighborhood Hits	201	Shared Neighborhood Hits	84
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

STAT2_MOUSE
NC score	0.020784 (rank : 1314)	θ value	0.00665767 (rank : 776)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

CA106_HUMAN
NC score	0.020727 (rank : 1315)	θ value	1.81305 (rank : 1050)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	45
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CB010_HUMAN
NC score	0.020403 (rank : 1316)	θ value	3.0926 (rank : 1134)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

ZC3H6_HUMAN
NC score	0.020395 (rank : 1317)	θ value	0.62314 (rank : 954)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

GAK5_HUMAN
NC score	0.020356 (rank : 1318)	θ value	0.365318 (rank : 909)
Query Neighborhood Hits	1407	Target Neighborhood Hits	429	Shared Neighborhood Hits	135
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CO5A2_HUMAN
NC score	0.020303 (rank : 1319)	θ value	0.0961366 (rank : 841)
Query Neighborhood Hits	1407	Target Neighborhood Hits	760	Shared Neighborhood Hits	178
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CP250_HUMAN
NC score	0.020166 (rank : 1320)	θ value	2.36792 (rank : 1098)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1805	Shared Neighborhood Hits	155
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

X3CL1_HUMAN
NC score	0.020144 (rank : 1321)	θ value	0.163984 (rank : 860)
Query Neighborhood Hits	1407	Target Neighborhood Hits	152	Shared Neighborhood Hits	51
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

MAGD4_HUMAN
NC score	0.020124 (rank : 1322)	θ value	1.38821 (rank : 1023)
Query Neighborhood Hits	1407	Target Neighborhood Hits	338	Shared Neighborhood Hits	121
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

SYNJ2_MOUSE
NC score	0.019991 (rank : 1323)	θ value	0.47712 (rank : 932)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	45
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

ABTAP_MOUSE
NC score	0.019943 (rank : 1324)	θ value	1.38821 (rank : 1004)
Query Neighborhood Hits	1407	Target Neighborhood Hits	381	Shared Neighborhood Hits	50
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

GAK6_HUMAN
NC score	0.019889 (rank : 1325)	θ value	0.62314 (rank : 944)
Query Neighborhood Hits	1407	Target Neighborhood Hits	392	Shared Neighborhood Hits	132
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.019875 (rank : 1326)	θ value	0.365318 (rank : 906)
Query Neighborhood Hits	1407	Target Neighborhood Hits	409	Shared Neighborhood Hits	133
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

NUMBL_MOUSE
NC score	0.019517 (rank : 1327)	θ value	6.88961 (rank : 1308)
Query Neighborhood Hits	1407	Target Neighborhood Hits	147	Shared Neighborhood Hits	55
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

GAK4_HUMAN
NC score	0.019457 (rank : 1328)	θ value	0.365318 (rank : 908)
Query Neighborhood Hits	1407	Target Neighborhood Hits	415	Shared Neighborhood Hits	135
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK2_HUMAN
NC score	0.019338 (rank : 1329)	θ value	0.365318 (rank : 907)
Query Neighborhood Hits	1407	Target Neighborhood Hits	406	Shared Neighborhood Hits	132
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PF21A_MOUSE
NC score	0.019224 (rank : 1330)	θ value	2.36792 (rank : 1118)
Query Neighborhood Hits	1407	Target Neighborhood Hits	285	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZPK0, Q6XVG0, Q80Z33, Q8CAZ4, Q8VEC8	Gene names	Phf21a, Bhc80, Kiaa1696, Pftf1
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (mBHC80) (BHC80a).

DMP1_HUMAN
NC score	0.019179 (rank : 1331)	θ value	0.47712 (rank : 924)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	65
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

SOX30_MOUSE
NC score	0.019103 (rank : 1332)	θ value	1.38821 (rank : 1039)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	112
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

FA8A1_HUMAN
NC score	0.019031 (rank : 1333)	θ value	2.36792 (rank : 1105)
Query Neighborhood Hits	1407	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBU6	Gene names	FAM8A1, AHCP
Domain Architecture	No domain graphic available
Description	Protein FAM8A1 (Autosomal highly conserved protein).

CUTL1_MOUSE
NC score	0.018767 (rank : 1334)	θ value	4.03905 (rank : 1171)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1620	Shared Neighborhood Hits	222
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CN004_MOUSE
NC score	0.018376 (rank : 1335)	θ value	5.27518 (rank : 1217)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

NFAC1_HUMAN
NC score	0.018359 (rank : 1336)	θ value	8.99809 (rank : 1379)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	126
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

UBN1_HUMAN
NC score	0.018335 (rank : 1337)	θ value	5.27518 (rank : 1260)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

CA106_MOUSE
NC score	0.018171 (rank : 1338)	θ value	4.03905 (rank : 1167)
Query Neighborhood Hits	1407	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CO5A1_MOUSE
NC score	0.017990 (rank : 1339)	θ value	6.88961 (rank : 1278)
Query Neighborhood Hits	1407	Target Neighborhood Hits	419	Shared Neighborhood Hits	130
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

YAP1_HUMAN
NC score	0.017989 (rank : 1340)	θ value	0.62314 (rank : 953)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	65
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BCOR_MOUSE
NC score	0.017922 (rank : 1341)	θ value	6.88961 (rank : 1271)
Query Neighborhood Hits	1407	Target Neighborhood Hits	521	Shared Neighborhood Hits	97
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CO5A1_HUMAN
NC score	0.017844 (rank : 1342)	θ value	5.27518 (rank : 1220)
Query Neighborhood Hits	1407	Target Neighborhood Hits	434	Shared Neighborhood Hits	129
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

RTN1_MOUSE
NC score	0.017840 (rank : 1343)	θ value	5.27518 (rank : 1248)
Query Neighborhood Hits	1407	Target Neighborhood Hits	189	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

CTND2_HUMAN
NC score	0.017809 (rank : 1344)	θ value	2.36792 (rank : 1100)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

GAK12_HUMAN
NC score	0.017789 (rank : 1345)	θ value	2.36792 (rank : 1106)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	119
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ABTAP_HUMAN
NC score	0.017759 (rank : 1346)	θ value	2.36792 (rank : 1082)
Query Neighborhood Hits	1407	Target Neighborhood Hits	290	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

GAK10_HUMAN
NC score	0.017575 (rank : 1347)	θ value	0.21417 (rank : 865)
Query Neighborhood Hits	1407	Target Neighborhood Hits	289	Shared Neighborhood Hits	92
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GOGB1_HUMAN
NC score	0.017387 (rank : 1348)	θ value	5.27518 (rank : 1229)
Query Neighborhood Hits	1407	Target Neighborhood Hits	2297	Shared Neighborhood Hits	201
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SF3B4_HUMAN
NC score	0.017299 (rank : 1349)	θ value	1.81305 (rank : 1077)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	130
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

MORC2_HUMAN
NC score	0.016884 (rank : 1350)	θ value	4.03905 (rank : 1187)
Query Neighborhood Hits	1407	Target Neighborhood Hits	207	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

USH1C_MOUSE
NC score	0.016883 (rank : 1351)	θ value	8.99809 (rank : 1403)
Query Neighborhood Hits	1407	Target Neighborhood Hits	557	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

NFAC4_HUMAN
NC score	0.016876 (rank : 1352)	θ value	1.06291 (rank : 992)
Query Neighborhood Hits	1407	Target Neighborhood Hits	165	Shared Neighborhood Hits	69
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

SIX5_MOUSE
NC score	0.016693 (rank : 1353)	θ value	0.125558 (rank : 851)
Query Neighborhood Hits	1407	Target Neighborhood Hits	354	Shared Neighborhood Hits	75
SwissProt Accessions	P70178	Gene names	Six5, Dmahp
Domain Architecture
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein homolog).

MAGD1_HUMAN
NC score	0.016451 (rank : 1354)	θ value	0.00390308 (rank : 760)
Query Neighborhood Hits	1407	Target Neighborhood Hits	130	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5V3, Q5VSH6, Q8IZ84, Q8WY92, Q9H352, Q9HBT4, Q9UF36	Gene names	MAGED1, NRAGE
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (MAGE tumor antigen CCF).

CCD91_MOUSE
NC score	0.016422 (rank : 1355)	θ value	4.03905 (rank : 1168)
Query Neighborhood Hits	1407	Target Neighborhood Hits	699	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

NRX2A_HUMAN
NC score	0.016372 (rank : 1356)	θ value	0.00390308 (rank : 761)
Query Neighborhood Hits	1407	Target Neighborhood Hits	614	Shared Neighborhood Hits	150
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

ASXL1_HUMAN
NC score	0.016278 (rank : 1357)	θ value	2.36792 (rank : 1086)
Query Neighborhood Hits	1407	Target Neighborhood Hits	260	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

CS021_HUMAN
NC score	0.016136 (rank : 1358)	θ value	0.62314 (rank : 941)
Query Neighborhood Hits	1407	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

PF21A_HUMAN
NC score	0.016088 (rank : 1359)	θ value	0.62314 (rank : 949)
Query Neighborhood Hits	1407	Target Neighborhood Hits	303	Shared Neighborhood Hits	57
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

CO1A2_MOUSE
NC score	0.015536 (rank : 1360)	θ value	3.0926 (rank : 1135)
Query Neighborhood Hits	1407	Target Neighborhood Hits	388	Shared Neighborhood Hits	109
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

TIF1G_MOUSE
NC score	0.015511 (rank : 1361)	θ value	8.99809 (rank : 1399)
Query Neighborhood Hits	1407	Target Neighborhood Hits	498	Shared Neighborhood Hits	120
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

CO4A1_MOUSE
NC score	0.015362 (rank : 1362)	θ value	8.99809 (rank : 1349)
Query Neighborhood Hits	1407	Target Neighborhood Hits	450	Shared Neighborhood Hits	132
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CUTL1_HUMAN
NC score	0.015331 (rank : 1363)	θ value	4.03905 (rank : 1170)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1574	Shared Neighborhood Hits	203
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CP045_MOUSE
NC score	0.015285 (rank : 1364)	θ value	0.279714 (rank : 883)
Query Neighborhood Hits	1407	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R1Y2, Q3UVX0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf45 homolog.

CP045_HUMAN
NC score	0.015171 (rank : 1365)	θ value	1.06291 (rank : 980)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q96MC5, O00223, O75769, Q8IZ36, Q96H25	Gene names	C16orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf45.

SIX5_HUMAN
NC score	0.015130 (rank : 1366)	θ value	3.0926 (rank : 1154)
Query Neighborhood Hits	1407	Target Neighborhood Hits	386	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

ZN750_HUMAN
NC score	0.015096 (rank : 1367)	θ value	8.99809 (rank : 1406)
Query Neighborhood Hits	1407	Target Neighborhood Hits	183	Shared Neighborhood Hits	60
SwissProt Accessions	Q32MQ0, Q9H899	Gene names	ZNF750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

LSD1_HUMAN
NC score	0.014951 (rank : 1368)	θ value	8.99809 (rank : 1376)
Query Neighborhood Hits	1407	Target Neighborhood Hits	455	Shared Neighborhood Hits	107
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

UBP42_HUMAN
NC score	0.014769 (rank : 1369)	θ value	0.0736092 (rank : 837)
Query Neighborhood Hits	1407	Target Neighborhood Hits	445	Shared Neighborhood Hits	125
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

COBA1_HUMAN
NC score	0.014764 (rank : 1370)	θ value	1.38821 (rank : 1008)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	124
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

PHLPP_HUMAN
NC score	0.014761 (rank : 1371)	θ value	0.365318 (rank : 913)
Query Neighborhood Hits	1407	Target Neighborhood Hits	604	Shared Neighborhood Hits	137
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PALB2_MOUSE
NC score	0.014669 (rank : 1372)	θ value	8.99809 (rank : 1385)
Query Neighborhood Hits	1407	Target Neighborhood Hits	133	Shared Neighborhood Hits	44
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

CP007_MOUSE
NC score	0.014581 (rank : 1373)	θ value	3.0926 (rank : 1136)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

CO2A1_HUMAN
NC score	0.014525 (rank : 1374)	θ value	6.88961 (rank : 1277)
Query Neighborhood Hits	1407	Target Neighborhood Hits	486	Shared Neighborhood Hits	129
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

BCL7C_MOUSE
NC score	0.014425 (rank : 1375)	θ value	2.36792 (rank : 1088)
Query Neighborhood Hits	1407	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

ISY1_HUMAN
NC score	0.014401 (rank : 1376)	θ value	0.163984 (rank : 856)
Query Neighborhood Hits	1407	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULR0, Q96IL2, Q9BT05	Gene names	KIAA1160
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor ISY1 homolog.

GR65_HUMAN
NC score	0.014377 (rank : 1377)	θ value	6.88961 (rank : 1294)
Query Neighborhood Hits	1407	Target Neighborhood Hits	148	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

NAT6_MOUSE
NC score	0.014375 (rank : 1378)	θ value	4.03905 (rank : 1188)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

IF31_HUMAN
NC score	0.014055 (rank : 1379)	θ value	1.81305 (rank : 1062)
Query Neighborhood Hits	1407	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75822, Q9BUD2, Q9H8Q2, Q9UI65	Gene names	EIF3S1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 1 (eIF-3 alpha) (eIF3 p35) (eIF3j).

GAB1_HUMAN
NC score	0.013943 (rank : 1380)	θ value	8.99809 (rank : 1362)
Query Neighborhood Hits	1407	Target Neighborhood Hits	279	Shared Neighborhood Hits	84
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CAC1G_HUMAN
NC score	0.013919 (rank : 1381)	θ value	2.36792 (rank : 1090)
Query Neighborhood Hits	1407	Target Neighborhood Hits	587	Shared Neighborhood Hits	164
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

UBP31_HUMAN
NC score	0.013904 (rank : 1382)	θ value	1.38821 (rank : 1042)
Query Neighborhood Hits	1407	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

MADCA_MOUSE
NC score	0.013841 (rank : 1383)	θ value	0.21417 (rank : 868)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	Q61826, O35530, Q61278, Q64275, Q8R1M6	Gene names	Madcam1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (mMAdCAM-1).

MAGI2_MOUSE
NC score	0.013704 (rank : 1384)	θ value	4.03905 (rank : 1184)
Query Neighborhood Hits	1407	Target Neighborhood Hits	370	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PO6F1_MOUSE
NC score	0.013660 (rank : 1385)	θ value	0.0193708 (rank : 803)
Query Neighborhood Hits	1407	Target Neighborhood Hits	581	Shared Neighborhood Hits	127
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

CO4A1_HUMAN
NC score	0.013361 (rank : 1386)	θ value	5.27518 (rank : 1219)
Query Neighborhood Hits	1407	Target Neighborhood Hits	425	Shared Neighborhood Hits	120
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

RPGR1_MOUSE
NC score	0.013208 (rank : 1387)	θ value	4.03905 (rank : 1194)
Query Neighborhood Hits	1407	Target Neighborhood Hits	713	Shared Neighborhood Hits	82
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

ETV3_HUMAN
NC score	0.013076 (rank : 1388)	θ value	5.27518 (rank : 1226)
Query Neighborhood Hits	1407	Target Neighborhood Hits	312	Shared Neighborhood Hits	87
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

UBQL3_HUMAN
NC score	0.013070 (rank : 1389)	θ value	0.163984 (rank : 859)
Query Neighborhood Hits	1407	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H347, Q9NRE0	Gene names	UBQLN3
Domain Architecture
Description	Ubiquilin-3.

FLIP1_HUMAN
NC score	0.013014 (rank : 1390)	θ value	6.88961 (rank : 1289)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1405	Shared Neighborhood Hits	118
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

ZC3H6_MOUSE
NC score	0.012842 (rank : 1391)	θ value	2.36792 (rank : 1128)
Query Neighborhood Hits	1407	Target Neighborhood Hits	239	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYK8, Q80UK3, Q8C1H1, Q9D604	Gene names	Zc3h6, Zc3hdc6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

ATX1_HUMAN
NC score	0.012646 (rank : 1392)	θ value	1.81305 (rank : 1048)
Query Neighborhood Hits	1407	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	P54253, Q9UJG2, Q9Y4J1	Gene names	ATXN1, ATX1, SCA1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein).

COG8_MOUSE
NC score	0.012571 (rank : 1393)	θ value	2.36792 (rank : 1096)
Query Neighborhood Hits	1407	Target Neighborhood Hits	147	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JJA2	Gene names	Cog8
Domain Architecture
Description	Conserved oligomeric Golgi complex component 8.

SYT8_HUMAN
NC score	0.012528 (rank : 1394)	θ value	0.813845 (rank : 973)
Query Neighborhood Hits	1407	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NBV8, Q9NSV9	Gene names	SYT8
Domain Architecture	No domain graphic available
Description	Synaptotagmin-8 (Synaptotagmin VIII) (SytVIII).

IL4RA_MOUSE
NC score	0.012501 (rank : 1395)	θ value	4.03905 (rank : 1181)
Query Neighborhood Hits	1407	Target Neighborhood Hits	194	Shared Neighborhood Hits	65
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

ANR40_MOUSE
NC score	0.012372 (rank : 1396)	θ value	8.99809 (rank : 1337)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

CEP68_HUMAN
NC score	0.012343 (rank : 1397)	θ value	5.27518 (rank : 1215)
Query Neighborhood Hits	1407	Target Neighborhood Hits	128	Shared Neighborhood Hits	46
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

MAGB6_HUMAN
NC score	0.012247 (rank : 1398)	θ value	2.36792 (rank : 1114)
Query Neighborhood Hits	1407	Target Neighborhood Hits	184	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

NUP98_HUMAN
NC score	0.012237 (rank : 1399)	θ value	1.81305 (rank : 1069)
Query Neighborhood Hits	1407	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	P52948, Q8IUT2, Q8WYB0, Q96E54, Q9H3Q4, Q9NT02, Q9UF57, Q9UHX0, Q9Y6J4, Q9Y6J5	Gene names	NUP98
Domain Architecture
Description	Nuclear pore complex protein Nup98-Nup96 precursor [Contains: Nuclear pore complex protein Nup98 (Nucleoporin Nup98) (98 kDa nucleoporin); Nuclear pore complex protein Nup96 (Nucleoporin Nup96) (96 kDa nucleoporin)].

MDFI_HUMAN
NC score	0.012220 (rank : 1400)	θ value	1.81305 (rank : 1066)
Query Neighborhood Hits	1407	Target Neighborhood Hits	45	Shared Neighborhood Hits	11
SwissProt Accessions	Q99750	Gene names	MDFI
Domain Architecture	No domain graphic available
Description	MyoD family inhibitor (Myogenic repressor I-mf).

AKA10_MOUSE
NC score	0.012133 (rank : 1401)	θ value	1.06291 (rank : 977)
Query Neighborhood Hits	1407	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	O88845, Q5SUB5, Q5SUB7, Q7TPE7, Q8BQL6	Gene names	Akap10
Domain Architecture	No domain graphic available
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

CD5R2_MOUSE
NC score	0.012092 (rank : 1402)	θ value	8.99809 (rank : 1344)
Query Neighborhood Hits	1407	Target Neighborhood Hits	57	Shared Neighborhood Hits	31
SwissProt Accessions	O35926, O35277	Gene names	Cdk5r2, Nck5ai
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

HELZ_HUMAN
NC score	0.012082 (rank : 1403)	θ value	2.36792 (rank : 1108)
Query Neighborhood Hits	1407	Target Neighborhood Hits	198	Shared Neighborhood Hits	58
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

RC3H1_HUMAN
NC score	0.012012 (rank : 1404)	θ value	0.21417 (rank : 873)
Query Neighborhood Hits	1407	Target Neighborhood Hits	433	Shared Neighborhood Hits	87
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

GMIP_MOUSE
NC score	0.011940 (rank : 1405)	θ value	4.03905 (rank : 1179)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SEPT9_MOUSE
NC score	0.011722 (rank : 1406)	θ value	5.27518 (rank : 1249)
Query Neighborhood Hits	1407	Target Neighborhood Hits	238	Shared Neighborhood Hits	67
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

GGA2_HUMAN
NC score	0.011643 (rank : 1407)	θ value	0.0193708 (rank : 800)
Query Neighborhood Hits	1407	Target Neighborhood Hits	114	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

SOX17_MOUSE
NC score	0.011538 (rank : 1408)	θ value	1.81305 (rank : 1078)
Query Neighborhood Hits	1407	Target Neighborhood Hits	223	Shared Neighborhood Hits	71
SwissProt Accessions	Q61473, Q61472, Q62248	Gene names	Sox17, Sox-17
Domain Architecture
Description	Transcription factor SOX-17.

AKA10_HUMAN
NC score	0.011058 (rank : 1409)	θ value	1.81305 (rank : 1047)
Query Neighborhood Hits	1407	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	O43572, Q96AJ7	Gene names	AKAP10
Domain Architecture
Description	A kinase anchor protein 10, mitochondrial precursor (Protein kinase A- anchoring protein 10) (PRKA10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2).

DAZP2_MOUSE
NC score	0.010760 (rank : 1410)	θ value	3.0926 (rank : 1138)
Query Neighborhood Hits	1407	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DCP9, O88675, Q3UVI4	Gene names	Dazap2, Prtb
Domain Architecture	No domain graphic available
Description	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich protein expressed in brain).

DYN3_HUMAN
NC score	0.010733 (rank : 1411)	θ value	6.88961 (rank : 1285)
Query Neighborhood Hits	1407	Target Neighborhood Hits	158	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

4ET_HUMAN
NC score	0.010714 (rank : 1412)	θ value	1.06291 (rank : 976)
Query Neighborhood Hits	1407	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NRA8, Q8NCF2, Q9H708	Gene names	EIF4ENIF1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

PLCB2_HUMAN
NC score	0.010571 (rank : 1413)	θ value	8.99809 (rank : 1390)
Query Neighborhood Hits	1407	Target Neighborhood Hits	608	Shared Neighborhood Hits	58
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

TTLL5_MOUSE
NC score	0.010562 (rank : 1414)	θ value	1.06291 (rank : 1001)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

ELF1_MOUSE
NC score	0.010548 (rank : 1415)	θ value	0.47712 (rank : 925)
Query Neighborhood Hits	1407	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

SNX15_HUMAN
NC score	0.010500 (rank : 1416)	θ value	5.27518 (rank : 1253)
Query Neighborhood Hits	1407	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRS6, Q9NRS5	Gene names	SNX15
Domain Architecture
Description	Sorting nexin-15.

UBXD3_MOUSE
NC score	0.010491 (rank : 1417)	θ value	1.38821 (rank : 1043)
Query Neighborhood Hits	1407	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

ODO2_HUMAN
NC score	0.010453 (rank : 1418)	θ value	8.99809 (rank : 1383)
Query Neighborhood Hits	1407	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

CAR10_HUMAN
NC score	0.010447 (rank : 1419)	θ value	3.0926 (rank : 1133)
Query Neighborhood Hits	1407	Target Neighborhood Hits	569	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

MAGD1_MOUSE
NC score	0.010419 (rank : 1420)	θ value	5.27518 (rank : 1236)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QYH6, Q543L6, Q99PB5, Q9CYX1	Gene names	Maged1, Nrage
Domain Architecture
Description	Melanoma-associated antigen D1 (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog) (Dlxin-1).

BRD2_HUMAN
NC score	0.010413 (rank : 1421)	θ value	2.36792 (rank : 1089)
Query Neighborhood Hits	1407	Target Neighborhood Hits	242	Shared Neighborhood Hits	48
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

JADE2_HUMAN
NC score	0.010157 (rank : 1422)	θ value	3.0926 (rank : 1143)
Query Neighborhood Hits	1407	Target Neighborhood Hits	199	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

RASF7_MOUSE
NC score	0.010004 (rank : 1423)	θ value	2.36792 (rank : 1121)
Query Neighborhood Hits	1407	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DD19	Gene names	Rassf7
Domain Architecture
Description	Ras association domain-containing protein 7.

CO9A1_HUMAN
NC score	0.009969 (rank : 1424)	θ value	1.81305 (rank : 1054)
Query Neighborhood Hits	1407	Target Neighborhood Hits	420	Shared Neighborhood Hits	100
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

GP178_HUMAN
NC score	0.009932 (rank : 1425)	θ value	5.27518 (rank : 1230)
Query Neighborhood Hits	1407	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2C4, Q5VTU1	Gene names	GPR178, KIAA1423
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR178.

ST5_HUMAN
NC score	0.009919 (rank : 1426)	θ value	4.03905 (rank : 1198)
Query Neighborhood Hits	1407	Target Neighborhood Hits	151	Shared Neighborhood Hits	57
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

SYNG_HUMAN
NC score	0.009859 (rank : 1427)	θ value	3.0926 (rank : 1156)
Query Neighborhood Hits	1407	Target Neighborhood Hits	160	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UMZ2, Q6ZT17	Gene names	AP1GBP1, SYNG
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

CR025_HUMAN
NC score	0.009568 (rank : 1428)	θ value	1.81305 (rank : 1055)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q96B23, Q5XG78, Q6N058, Q86TB5, Q8TCQ5	Gene names	C18orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf25.

GP152_HUMAN
NC score	0.009510 (rank : 1429)	θ value	0.813845 (rank : 964)
Query Neighborhood Hits	1407	Target Neighborhood Hits	636	Shared Neighborhood Hits	129
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

NONO_HUMAN
NC score	0.009250 (rank : 1430)	θ value	8.99809 (rank : 1381)
Query Neighborhood Hits	1407	Target Neighborhood Hits	441	Shared Neighborhood Hits	42
SwissProt Accessions	Q15233, O00201, P30807, Q12786, Q9BQC5	Gene names	NONO, NRB54
Domain Architecture
Description	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit).

ST5_MOUSE
NC score	0.009225 (rank : 1431)	θ value	4.03905 (rank : 1199)
Query Neighborhood Hits	1407	Target Neighborhood Hits	126	Shared Neighborhood Hits	49
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

CO9A1_MOUSE
NC score	0.008973 (rank : 1432)	θ value	6.88961 (rank : 1279)
Query Neighborhood Hits	1407	Target Neighborhood Hits	477	Shared Neighborhood Hits	112
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CR025_MOUSE
NC score	0.008920 (rank : 1433)	θ value	4.03905 (rank : 1169)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BH50, Q3TQ72, Q8BU43	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf25 homolog.

GGA3_HUMAN
NC score	0.008888 (rank : 1434)	θ value	4.03905 (rank : 1178)
Query Neighborhood Hits	1407	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

PI51C_HUMAN
NC score	0.008871 (rank : 1435)	θ value	0.813845 (rank : 970)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	30
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

TAF9_MOUSE
NC score	0.008838 (rank : 1436)	θ value	4.03905 (rank : 1200)
Query Neighborhood Hits	1407	Target Neighborhood Hits	69	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VI33, Q32P09, Q80XS3, Q9CV61	Gene names	Taf9, Taf2g
Domain Architecture
Description	Transcription initiation factor TFIID subunit 9 (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII-32) (TAFII32).

TULP1_HUMAN
NC score	0.008777 (rank : 1437)	θ value	6.88961 (rank : 1332)
Query Neighborhood Hits	1407	Target Neighborhood Hits	144	Shared Neighborhood Hits	37
SwissProt Accessions	O00294, O43536	Gene names	TULP1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

SRTD1_MOUSE
NC score	0.008690 (rank : 1438)	θ value	2.36792 (rank : 1124)
Query Neighborhood Hits	1407	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

LRFN4_HUMAN
NC score	0.008582 (rank : 1439)	θ value	8.99809 (rank : 1375)
Query Neighborhood Hits	1407	Target Neighborhood Hits	462	Shared Neighborhood Hits	50
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

KCNH6_HUMAN
NC score	0.008556 (rank : 1440)	θ value	2.36792 (rank : 1112)
Query Neighborhood Hits	1407	Target Neighborhood Hits	222	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

PTTG1_MOUSE
NC score	0.008544 (rank : 1441)	θ value	1.81305 (rank : 1073)
Query Neighborhood Hits	1407	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

ETV5_MOUSE
NC score	0.008449 (rank : 1442)	θ value	3.0926 (rank : 1139)
Query Neighborhood Hits	1407	Target Neighborhood Hits	328	Shared Neighborhood Hits	105
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

KCNK4_MOUSE
NC score	0.008440 (rank : 1443)	θ value	0.0736092 (rank : 833)
Query Neighborhood Hits	1407	Target Neighborhood Hits	118	Shared Neighborhood Hits	30
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

COEA1_HUMAN
NC score	0.008334 (rank : 1444)	θ value	6.88961 (rank : 1280)
Query Neighborhood Hits	1407	Target Neighborhood Hits	427	Shared Neighborhood Hits	105
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

NCOA1_MOUSE
NC score	0.008330 (rank : 1445)	θ value	0.365318 (rank : 912)
Query Neighborhood Hits	1407	Target Neighborhood Hits	196	Shared Neighborhood Hits	48
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

RILP_HUMAN
NC score	0.008293 (rank : 1446)	θ value	6.88961 (rank : 1316)
Query Neighborhood Hits	1407	Target Neighborhood Hits	249	Shared Neighborhood Hits	36
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

PARP4_HUMAN
NC score	0.008249 (rank : 1447)	θ value	3.0926 (rank : 1149)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

SYGP1_HUMAN
NC score	0.008228 (rank : 1448)	θ value	6.88961 (rank : 1324)
Query Neighborhood Hits	1407	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

CENG1_HUMAN
NC score	0.008214 (rank : 1449)	θ value	8.99809 (rank : 1347)
Query Neighborhood Hits	1407	Target Neighborhood Hits	544	Shared Neighborhood Hits	91
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

PTCD1_HUMAN
NC score	0.008192 (rank : 1450)	θ value	6.88961 (rank : 1313)
Query Neighborhood Hits	1407	Target Neighborhood Hits	52	Shared Neighborhood Hits	23
SwissProt Accessions	O75127, Q66K60, Q9UDV2	Gene names	PTCD1, KIAA0632
Domain Architecture	No domain graphic available
Description	Pentatricopeptide repeat protein 1.

DAZP2_HUMAN
NC score	0.008162 (rank : 1451)	θ value	8.99809 (rank : 1351)
Query Neighborhood Hits	1407	Target Neighborhood Hits	33	Shared Neighborhood Hits	14
SwissProt Accessions	Q15038	Gene names	DAZAP2, KIAA0058
Domain Architecture	No domain graphic available
Description	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2).

CEP72_HUMAN
NC score	0.008025 (rank : 1452)	θ value	1.81305 (rank : 1052)
Query Neighborhood Hits	1407	Target Neighborhood Hits	374	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

PHF22_HUMAN
NC score	0.007992 (rank : 1453)	θ value	6.88961 (rank : 1311)
Query Neighborhood Hits	1407	Target Neighborhood Hits	121	Shared Neighborhood Hits	34
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

LAT_MOUSE
NC score	0.007963 (rank : 1454)	θ value	5.27518 (rank : 1235)
Query Neighborhood Hits	1407	Target Neighborhood Hits	31	Shared Neighborhood Hits	15
SwissProt Accessions	O54957	Gene names	Lat
Domain Architecture	No domain graphic available
Description	Linker for activation of T-cells family member 1 (36 kDa phospho- tyrosine adapter protein) (pp36) (p36-38).

RGS12_HUMAN
NC score	0.007953 (rank : 1455)	θ value	4.03905 (rank : 1193)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	71
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

US6NL_HUMAN
NC score	0.007947 (rank : 1456)	θ value	6.88961 (rank : 1334)
Query Neighborhood Hits	1407	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

REL_MOUSE
NC score	0.007836 (rank : 1457)	θ value	0.0961366 (rank : 845)
Query Neighborhood Hits	1407	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

RECQ5_HUMAN
NC score	0.007830 (rank : 1458)	θ value	0.813845 (rank : 971)
Query Neighborhood Hits	1407	Target Neighborhood Hits	390	Shared Neighborhood Hits	101
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

IP3KA_HUMAN
NC score	0.007802 (rank : 1459)	θ value	0.62314 (rank : 946)
Query Neighborhood Hits	1407	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

COEA1_MOUSE
NC score	0.007769 (rank : 1460)	θ value	2.36792 (rank : 1095)
Query Neighborhood Hits	1407	Target Neighborhood Hits	402	Shared Neighborhood Hits	93
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

NECP2_MOUSE
NC score	0.007724 (rank : 1461)	θ value	1.38821 (rank : 1028)
Query Neighborhood Hits	1407	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D1J1, Q3U1M1, Q9CV41	Gene names	Necap2
Domain Architecture	No domain graphic available
Description	Adaptin ear-binding coat-associated protein 2 (NECAP-2).

CD5R2_HUMAN
NC score	0.007705 (rank : 1462)	θ value	8.99809 (rank : 1343)
Query Neighborhood Hits	1407	Target Neighborhood Hits	53	Shared Neighborhood Hits	30
SwissProt Accessions	Q13319, Q4ZFW6	Gene names	CDK5R2, NCK5AI
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

ELK4_HUMAN
NC score	0.007596 (rank : 1463)	θ value	5.27518 (rank : 1224)
Query Neighborhood Hits	1407	Target Neighborhood Hits	184	Shared Neighborhood Hits	63
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

BNC2_HUMAN
NC score	0.007512 (rank : 1464)	θ value	0.813845 (rank : 957)
Query Neighborhood Hits	1407	Target Neighborhood Hits	439	Shared Neighborhood Hits	47
SwissProt Accessions	Q6ZN30, Q6T3A3, Q8NAR2, Q9H6J0, Q9NXV0	Gene names	BNC2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

XPC_HUMAN
NC score	0.007499 (rank : 1465)	θ value	6.88961 (rank : 1335)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	17
SwissProt Accessions	Q01831, Q96AX0	Gene names	XPC, XPCC
Domain Architecture
Description	DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125).

P73L_HUMAN
NC score	0.007442 (rank : 1466)	θ value	6.88961 (rank : 1309)
Query Neighborhood Hits	1407	Target Neighborhood Hits	102	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

BNC2_MOUSE
NC score	0.007349 (rank : 1467)	θ value	0.813845 (rank : 958)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BMQ3, Q6T3A4	Gene names	Bnc2
Domain Architecture	No domain graphic available
Description	Zinc finger protein basonuclin-2.

AKAP8_HUMAN
NC score	0.007279 (rank : 1468)	θ value	0.47712 (rank : 921)
Query Neighborhood Hits	1407	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

NPAS2_HUMAN
NC score	0.007259 (rank : 1469)	θ value	6.88961 (rank : 1307)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	45
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

DNM3A_MOUSE
NC score	0.007107 (rank : 1470)	θ value	1.81305 (rank : 1057)
Query Neighborhood Hits	1407	Target Neighborhood Hits	91	Shared Neighborhood Hits	31
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

K1849_MOUSE
NC score	0.007087 (rank : 1471)	θ value	0.279714 (rank : 888)
Query Neighborhood Hits	1407	Target Neighborhood Hits	335	Shared Neighborhood Hits	66
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ERCC5_MOUSE
NC score	0.007073 (rank : 1472)	θ value	6.88961 (rank : 1287)
Query Neighborhood Hits	1407	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

RTEL1_HUMAN
NC score	0.006877 (rank : 1473)	θ value	1.81305 (rank : 1075)
Query Neighborhood Hits	1407	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

NAB2_MOUSE
NC score	0.006776 (rank : 1474)	θ value	1.38821 (rank : 1027)
Query Neighborhood Hits	1407	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61127	Gene names	Nab2
Domain Architecture
Description	NGFI-A-binding protein 2 (EGR-1-binding protein 2).

DNM3A_HUMAN
NC score	0.006618 (rank : 1475)	θ value	8.99809 (rank : 1354)
Query Neighborhood Hits	1407	Target Neighborhood Hits	104	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

MPP9_HUMAN
NC score	0.006496 (rank : 1476)	θ value	5.27518 (rank : 1238)
Query Neighborhood Hits	1407	Target Neighborhood Hits	529	Shared Neighborhood Hits	47
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

PI51C_MOUSE
NC score	0.006388 (rank : 1477)	θ value	0.279714 (rank : 894)
Query Neighborhood Hits	1407	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

TBX21_MOUSE
NC score	0.006227 (rank : 1478)	θ value	0.0736092 (rank : 836)
Query Neighborhood Hits	1407	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

PALB2_HUMAN
NC score	0.006007 (rank : 1479)	θ value	8.99809 (rank : 1384)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	25
SwissProt Accessions	Q86YC2, Q8N7Y6, Q8ND31, Q9H6W1	Gene names	PALB2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

CK035_MOUSE
NC score	0.005893 (rank : 1480)	θ value	6.88961 (rank : 1276)
Query Neighborhood Hits	1407	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

PKHA4_MOUSE
NC score	0.005876 (rank : 1481)	θ value	6.88961 (rank : 1312)
Query Neighborhood Hits	1407	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RUNX1_MOUSE
NC score	0.005814 (rank : 1482)	θ value	4.03905 (rank : 1195)
Query Neighborhood Hits	1407	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

OSBP2_MOUSE
NC score	0.005801 (rank : 1483)	θ value	0.21417 (rank : 872)
Query Neighborhood Hits	1407	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

DAXX_MOUSE
NC score	0.005770 (rank : 1484)	θ value	5.27518 (rank : 1221)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	26
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

CEA19_HUMAN
NC score	0.005769 (rank : 1485)	θ value	1.81305 (rank : 1051)
Query Neighborhood Hits	1407	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

NMDE4_HUMAN
NC score	0.005557 (rank : 1486)	θ value	0.125558 (rank : 850)
Query Neighborhood Hits	1407	Target Neighborhood Hits	133	Shared Neighborhood Hits	45
SwissProt Accessions	O15399	Gene names	GRIN2D
Domain Architecture
Description	Glutamate [NMDA] receptor subunit epsilon 4 precursor (N-methyl D- aspartate receptor subtype 2D) (NR2D) (NMDAR2D) (EB11).

SAV1_MOUSE
NC score	0.005462 (rank : 1487)	θ value	1.38821 (rank : 1035)
Query Neighborhood Hits	1407	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

TMEM8_HUMAN
NC score	0.005461 (rank : 1488)	θ value	3.0926 (rank : 1159)
Query Neighborhood Hits	1407	Target Neighborhood Hits	27	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCN3, Q4TT35, Q8WU24, Q96S25, Q9BR03, Q9BT97, Q9H7B9	Gene names	TMEM8
Domain Architecture	No domain graphic available
Description	Transmembrane protein 8 precursor (M83 protein).

SNRPA_HUMAN
NC score	0.005461 (rank : 1489)	θ value	5.27518 (rank : 1252)
Query Neighborhood Hits	1407	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	P09012	Gene names	SNRPA
Domain Architecture
Description	U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1A protein) (U1-A).

BHLH2_HUMAN
NC score	0.005389 (rank : 1490)	θ value	0.47712 (rank : 922)
Query Neighborhood Hits	1407	Target Neighborhood Hits	80	Shared Neighborhood Hits	11
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

GRIP1_HUMAN
NC score	0.005106 (rank : 1491)	θ value	8.99809 (rank : 1364)
Query Neighborhood Hits	1407	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DEND_MOUSE
NC score	0.005058 (rank : 1492)	θ value	6.88961 (rank : 1282)
Query Neighborhood Hits	1407	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q80TS7	Gene names	Ddn, Kiaa0749
Domain Architecture	No domain graphic available
Description	Dendrin.

SNRPA_MOUSE
NC score	0.004846 (rank : 1493)	θ value	8.99809 (rank : 1395)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	25
SwissProt Accessions	Q62189, Q52LA2	Gene names	Snrpa, Rnu1a-1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1A protein) (U1-A).

ACY1_HUMAN
NC score	0.004783 (rank : 1494)	θ value	6.88961 (rank : 1265)
Query Neighborhood Hits	1407	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q03154	Gene names	ACY1
Domain Architecture
Description	Aminoacylase-1 (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) (ACY-1).

FGD3_HUMAN
NC score	0.004770 (rank : 1495)	θ value	1.06291 (rank : 982)
Query Neighborhood Hits	1407	Target Neighborhood Hits	249	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

SL9A5_HUMAN
NC score	0.004755 (rank : 1496)	θ value	0.365318 (rank : 914)
Query Neighborhood Hits	1407	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

NOTC2_HUMAN
NC score	0.004622 (rank : 1497)	θ value	0.279714 (rank : 893)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1113	Shared Neighborhood Hits	162
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

LAG3_HUMAN
NC score	0.004550 (rank : 1498)	θ value	6.88961 (rank : 1301)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	18
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

PKNX2_MOUSE
NC score	0.004546 (rank : 1499)	θ value	1.38821 (rank : 1030)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BG99, Q8R4B0	Gene names	Pknox2, Prep2
Domain Architecture	No domain graphic available
Description	Homeobox protein PKNOX2 (PBX/knotted homeobox 2) (Homeobox protein PREP-2).

TMM26_MOUSE
NC score	0.004079 (rank : 1500)	θ value	5.27518 (rank : 1259)
Query Neighborhood Hits	1407	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UP23, Q8BN94	Gene names	Tmem26
Domain Architecture	No domain graphic available
Description	Transmembrane protein 26.

NGEF_MOUSE
NC score	0.004005 (rank : 1501)	θ value	8.99809 (rank : 1380)
Query Neighborhood Hits	1407	Target Neighborhood Hits	228	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

CYLD_MOUSE
NC score	0.003969 (rank : 1502)	θ value	2.36792 (rank : 1101)
Query Neighborhood Hits	1407	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0	Gene names	Cyld, Cyld1, Kiaa0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

PHF8_HUMAN
NC score	0.003898 (rank : 1503)	θ value	1.06291 (rank : 994)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

SOX18_HUMAN
NC score	0.003889 (rank : 1504)	θ value	4.03905 (rank : 1196)
Query Neighborhood Hits	1407	Target Neighborhood Hits	106	Shared Neighborhood Hits	21
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

XYLT2_HUMAN
NC score	0.003820 (rank : 1505)	θ value	2.36792 (rank : 1127)
Query Neighborhood Hits	1407	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H1B5, Q6UY41, Q86V00	Gene names	XYLT2, XT2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (xylT-II) (XT-II) (Peptide O-xylosyltransferase 1).

DMRTC_HUMAN
NC score	0.003765 (rank : 1506)	θ value	6.88961 (rank : 1283)
Query Neighborhood Hits	1407	Target Neighborhood Hits	15	Shared Neighborhood Hits	5
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

SEZ6L_HUMAN
NC score	0.003708 (rank : 1507)	θ value	5.27518 (rank : 1250)
Query Neighborhood Hits	1407	Target Neighborhood Hits	289	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

IRF3_HUMAN
NC score	0.003698 (rank : 1508)	θ value	6.88961 (rank : 1297)
Query Neighborhood Hits	1407	Target Neighborhood Hits	129	Shared Neighborhood Hits	37
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

ADA12_MOUSE
NC score	0.003619 (rank : 1509)	θ value	0.0193708 (rank : 798)
Query Neighborhood Hits	1407	Target Neighborhood Hits	474	Shared Neighborhood Hits	119
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

TNR3_HUMAN
NC score	0.003436 (rank : 1510)	θ value	0.47712 (rank : 936)
Query Neighborhood Hits	1407	Target Neighborhood Hits	145	Shared Neighborhood Hits	24
SwissProt Accessions	P36941	Gene names	LTBR, TNFCR, TNFRSF3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor C receptor).

B4GT1_HUMAN
NC score	0.003426 (rank : 1511)	θ value	8.99809 (rank : 1339)
Query Neighborhood Hits	1407	Target Neighborhood Hits	168	Shared Neighborhood Hits	45
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

STA5B_MOUSE
NC score	0.003403 (rank : 1512)	θ value	5.27518 (rank : 1256)
Query Neighborhood Hits	1407	Target Neighborhood Hits	124	Shared Neighborhood Hits	20
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

DPOLA_MOUSE
NC score	0.003214 (rank : 1513)	θ value	5.27518 (rank : 1223)
Query Neighborhood Hits	1407	Target Neighborhood Hits	56	Shared Neighborhood Hits	12
SwissProt Accessions	P33609	Gene names	Pola1, Pola
Domain Architecture
Description	DNA polymerase alpha catalytic subunit (EC 2.7.7.7).

GP152_MOUSE
NC score	0.003126 (rank : 1514)	θ value	1.38821 (rank : 1016)
Query Neighborhood Hits	1407	Target Neighborhood Hits	607	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

THSD1_MOUSE
NC score	0.003066 (rank : 1515)	θ value	5.27518 (rank : 1258)
Query Neighborhood Hits	1407	Target Neighborhood Hits	153	Shared Neighborhood Hits	25
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TREF1_HUMAN
NC score	0.002994 (rank : 1516)	θ value	6.88961 (rank : 1330)
Query Neighborhood Hits	1407	Target Neighborhood Hits	651	Shared Neighborhood Hits	89
SwissProt Accessions	Q96PN7, Q7Z6T2, Q7Z6T3, Q9NQ72, Q9NQ73, Q9NUN9	Gene names	TRERF1, RAPA, TREP132
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132) (Zinc finger protein rapa).

K0423_MOUSE
NC score	0.002934 (rank : 1517)	θ value	8.99809 (rank : 1371)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q6A070	Gene names	Kiaa0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

CECR6_HUMAN
NC score	0.002848 (rank : 1518)	θ value	8.99809 (rank : 1346)
Query Neighborhood Hits	1407	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BXQ6	Gene names	CECR6
Domain Architecture	No domain graphic available
Description	Cat eye syndrome critical region protein 6.

SOX8_HUMAN
NC score	0.002808 (rank : 1519)	θ value	1.06291 (rank : 999)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

FOXN1_HUMAN
NC score	0.002808 (rank : 1520)	θ value	8.99809 (rank : 1359)
Query Neighborhood Hits	1407	Target Neighborhood Hits	377	Shared Neighborhood Hits	116
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

XYLT2_MOUSE
NC score	0.002749 (rank : 1521)	θ value	8.99809 (rank : 1404)
Query Neighborhood Hits	1407	Target Neighborhood Hits	30	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EPL0, Q5SUY1, Q8K060	Gene names	Xylt2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (Peptide O- xylosyltransferase 2).

HXA3_HUMAN
NC score	0.002684 (rank : 1522)	θ value	2.36792 (rank : 1109)
Query Neighborhood Hits	1407	Target Neighborhood Hits	535	Shared Neighborhood Hits	139
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

RXRB_HUMAN
NC score	0.002594 (rank : 1523)	θ value	6.88961 (rank : 1319)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	104
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

DX26B_MOUSE
NC score	0.002553 (rank : 1524)	θ value	6.88961 (rank : 1284)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BND4	Gene names
Domain Architecture	No domain graphic available
Description	Protein DDX26B.

VAPB_HUMAN
NC score	0.002500 (rank : 1525)	θ value	5.27518 (rank : 1261)
Query Neighborhood Hits	1407	Target Neighborhood Hits	39	Shared Neighborhood Hits	6
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

TBX2_HUMAN
NC score	0.002459 (rank : 1526)	θ value	5.27518 (rank : 1257)
Query Neighborhood Hits	1407	Target Neighborhood Hits	195	Shared Neighborhood Hits	52
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

CM003_MOUSE
NC score	0.002344 (rank : 1527)	θ value	8.99809 (rank : 1348)
Query Neighborhood Hits	1407	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C263	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf3 homolog.

PTPRN_MOUSE
NC score	0.002276 (rank : 1528)	θ value	0.0563607 (rank : 831)
Query Neighborhood Hits	1407	Target Neighborhood Hits	240	Shared Neighborhood Hits	68
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

DMN_HUMAN
NC score	0.002215 (rank : 1529)	θ value	2.36792 (rank : 1102)
Query Neighborhood Hits	1407	Target Neighborhood Hits	690	Shared Neighborhood Hits	85
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

RNF37_HUMAN
NC score	0.001855 (rank : 1530)	θ value	5.27518 (rank : 1247)
Query Neighborhood Hits	1407	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	O94941	Gene names	UBOX5, KIAA0860, RNF37, UBCE7IP5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (U-box domain-containing protein 5).

DEMA_MOUSE
NC score	0.001817 (rank : 1531)	θ value	4.03905 (rank : 1173)
Query Neighborhood Hits	1407	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV69	Gene names	Epb49, Epb4.9
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

CHD5_HUMAN
NC score	0.001795 (rank : 1532)	θ value	0.365318 (rank : 901)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

FOG1_MOUSE
NC score	0.001644 (rank : 1533)	θ value	0.813845 (rank : 963)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1237	Shared Neighborhood Hits	246
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ETV4_HUMAN
NC score	0.001632 (rank : 1534)	θ value	6.88961 (rank : 1288)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	P43268, Q96AW9	Gene names	ETV4, E1AF
Domain Architecture	No domain graphic available
Description	ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F).

TBX21_HUMAN
NC score	0.001610 (rank : 1535)	θ value	6.88961 (rank : 1327)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL17	Gene names	TBX21, TBET, TBLYM
Domain Architecture
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

PTN22_MOUSE
NC score	0.001571 (rank : 1536)	θ value	0.279714 (rank : 895)
Query Neighborhood Hits	1407	Target Neighborhood Hits	179	Shared Neighborhood Hits	43
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

DEMA_HUMAN
NC score	0.001564 (rank : 1537)	θ value	8.99809 (rank : 1352)
Query Neighborhood Hits	1407	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q08495, Q13215, Q9BRE3	Gene names	EPB49, DMT
Domain Architecture
Description	Dematin (Erythrocyte membrane protein band 4.9).

ETV4_MOUSE
NC score	0.001563 (rank : 1538)	θ value	8.99809 (rank : 1355)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

VMDL1_HUMAN
NC score	0.001550 (rank : 1539)	θ value	4.03905 (rank : 1205)
Query Neighborhood Hits	1407	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFU1, Q9NXP0	Gene names	VMD2L1
Domain Architecture
Description	Bestrophin-2 (Vitelliform macular dystrophy 2-like protein 1).

GMEB2_MOUSE
NC score	0.001503 (rank : 1540)	θ value	8.99809 (rank : 1363)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	P58929, Q6PCY0	Gene names	Gmeb2
Domain Architecture	No domain graphic available
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2).

KCNQ1_MOUSE
NC score	0.001457 (rank : 1541)	θ value	0.279714 (rank : 889)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

OSBL9_HUMAN
NC score	0.001421 (rank : 1542)	θ value	5.27518 (rank : 1239)
Query Neighborhood Hits	1407	Target Neighborhood Hits	138	Shared Neighborhood Hits	22
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

FRM4B_MOUSE
NC score	0.001329 (rank : 1543)	θ value	1.81305 (rank : 1059)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

B4GN1_HUMAN
NC score	0.001232 (rank : 1544)	θ value	6.88961 (rank : 1269)
Query Neighborhood Hits	1407	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q00973	Gene names	B4GALNT1, GALGT, SIAT2
Domain Architecture
Description	Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) ((N- acetylneuraminyl)-galactosylglucosylceramide) (GM2/GD2 synthase) (GalNAc-T).

TGIF_HUMAN
NC score	0.001076 (rank : 1545)	θ value	1.38821 (rank : 1041)
Query Neighborhood Hits	1407	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	Q15583, Q6ICR0, Q8N5X9, Q9NRS0	Gene names	TGIF
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

GT2D1_HUMAN
NC score	0.001015 (rank : 1546)	θ value	8.99809 (rank : 1365)
Query Neighborhood Hits	1407	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UHL9, O95444, Q75MX7, Q86UM3, Q8WVC4, Q9UHK8, Q9UI91	Gene names	GTF2IRD1, CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, WBSCR12
Domain Architecture
Description	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (Muscle TFII-I repeat domain-containing protein 1) (General transcription factor III) (Slow- muscle-fiber enhancer-binding protein) (USE B1-binding protein) (MusTRD1/BEN) (Williams-Beuren syndrome chromosome region 11 protein).

HDAC6_MOUSE
NC score	0.000918 (rank : 1547)	θ value	1.06291 (rank : 985)
Query Neighborhood Hits	1407	Target Neighborhood Hits	88	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

OAS3_HUMAN
NC score	0.000841 (rank : 1548)	θ value	8.99809 (rank : 1382)
Query Neighborhood Hits	1407	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6K5, Q9H3P5	Gene names	OAS3
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 3 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 3) (2-5A synthetase 3) (p100 OAS) (p100OAS).

ENW1_HUMAN
NC score	0.000835 (rank : 1549)	θ value	5.27518 (rank : 1225)
Query Neighborhood Hits	1407	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQF0, O95244, O95245, Q8NHY7, Q9NRZ2, Q9NZG3	Gene names	ERVWE1
Domain Architecture
Description	HERV-W_7q21.2 provirus ancestral Env polyprotein precursor (Envelope polyprotein gPr73) (HERV-7q Envelope protein) (HERV-W envelope protein) (Syncytin) (Syncytin-1) (Enverin) (Env-W) [Contains: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)].

NOTC2_MOUSE
NC score	0.000813 (rank : 1550)	θ value	3.0926 (rank : 1148)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1069	Shared Neighborhood Hits	131
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PLS1_HUMAN
NC score	0.000798 (rank : 1551)	θ value	8.99809 (rank : 1391)
Query Neighborhood Hits	1407	Target Neighborhood Hits	35	Shared Neighborhood Hits	13
SwissProt Accessions	O15162	Gene names	PLSCR1
Domain Architecture
Description	Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (MmTRA1b).

PANK2_HUMAN
NC score	0.000787 (rank : 1552)	θ value	4.03905 (rank : 1190)
Query Neighborhood Hits	1407	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ23, Q5T7I2, Q8N7Q4, Q8TCR5, Q9BYW5, Q9HAF2	Gene names	PANK2, C20orf48
Domain Architecture
Description	Pantothenate kinase 2, mitochondrial precursor (EC 2.7.1.33) (Pantothenic acid kinase 2) (hPANK2).

ZDH14_HUMAN
NC score	0.000588 (rank : 1553)	θ value	0.813845 (rank : 974)
Query Neighborhood Hits	1407	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZN3, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q9H7F1	Gene names	ZDHHC14
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP).

C1QT5_HUMAN
NC score	0.000571 (rank : 1554)	θ value	4.03905 (rank : 1166)
Query Neighborhood Hits	1407	Target Neighborhood Hits	137	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BXJ0, Q8N6P2, Q9UFX4	Gene names	C1QTNF5, CTRP5
Domain Architecture
Description	Complement C1q tumor necrosis factor-related protein 5 precursor.

SMP1L_HUMAN
NC score	0.000459 (rank : 1555)	θ value	6.88961 (rank : 1323)
Query Neighborhood Hits	1407	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

FXR2_HUMAN
NC score	0.000426 (rank : 1556)	θ value	6.88961 (rank : 1292)
Query Neighborhood Hits	1407	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

FRM4B_HUMAN
NC score	0.000425 (rank : 1557)	θ value	1.38821 (rank : 1014)
Query Neighborhood Hits	1407	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y2L6, Q8TAI3	Gene names	FRMD4B, KIAA1013
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1).

UBP6_HUMAN
NC score	0.000407 (rank : 1558)	θ value	0.47712 (rank : 937)
Query Neighborhood Hits	1407	Target Neighborhood Hits	188	Shared Neighborhood Hits	35
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

TENN_HUMAN
NC score	0.000397 (rank : 1559)	θ value	2.36792 (rank : 1126)
Query Neighborhood Hits	1407	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

PRGR_MOUSE
NC score	0.000158 (rank : 1560)	θ value	1.06291 (rank : 996)
Query Neighborhood Hits	1407	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

MYCL1_HUMAN
NC score	-0.000018 (rank : 1561)	θ value	8.99809 (rank : 1377)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

IRF7_MOUSE
NC score	-0.000050 (rank : 1562)	θ value	4.03905 (rank : 1182)
Query Neighborhood Hits	1407	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P70434	Gene names	Irf7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

PRDM2_HUMAN
NC score	-0.000272 (rank : 1563)	θ value	4.03905 (rank : 1192)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1135	Shared Neighborhood Hits	208
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

ZDH14_MOUSE
NC score	-0.000416 (rank : 1564)	θ value	3.0926 (rank : 1163)
Query Neighborhood Hits	1407	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BQQ1, Q8BNR2, Q8CFN0	Gene names	Zdhhc14
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC14 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 14) (DHHC-14) (NEW1 domain-containing protein) (NEW1CP).

C1QT5_MOUSE
NC score	-0.000459 (rank : 1565)	θ value	6.88961 (rank : 1274)
Query Neighborhood Hits	1407	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K479	Gene names	C1qtnf5, Ctrp5
Domain Architecture	No domain graphic available
Description	Complement C1q tumor necrosis factor-related protein 5 precursor.

C1QR1_HUMAN
NC score	-0.000522 (rank : 1566)	θ value	1.06291 (rank : 978)
Query Neighborhood Hits	1407	Target Neighborhood Hits	493	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NPY3, O00274	Gene names	CD93, C1QR1, MXRA4
Domain Architecture
Description	Complement component C1q receptor precursor (Complement component 1 q subcomponent receptor 1) (C1qR) (C1qRp) (C1qR(p)) (C1q/MBL/SPA receptor) (CD93 antigen) (CDw93).

E2F1_MOUSE
NC score	-0.000574 (rank : 1567)	θ value	6.88961 (rank : 1286)
Query Neighborhood Hits	1407	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q61501, Q80VZ3	Gene names	E2f1
Domain Architecture
Description	Transcription factor E2F1 (E2F-1).

B3A2_MOUSE
NC score	-0.000622 (rank : 1568)	θ value	5.27518 (rank : 1211)
Query Neighborhood Hits	1407	Target Neighborhood Hits	64	Shared Neighborhood Hits	23
SwissProt Accessions	P13808, Q9ES09, Q9ES10, Q9ES11, Q9ES12, Q9ES13	Gene names	Slc4a2, Ae2
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (B3RP).

RHG06_MOUSE
NC score	-0.000673 (rank : 1569)	θ value	6.88961 (rank : 1315)
Query Neighborhood Hits	1407	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

TBX4_HUMAN
NC score	-0.000690 (rank : 1570)	θ value	6.88961 (rank : 1328)
Query Neighborhood Hits	1407	Target Neighborhood Hits	70	Shared Neighborhood Hits	16
SwissProt Accessions	P57082	Gene names	TBX4
Domain Architecture
Description	T-box transcription factor TBX4 (T-box protein 4).

SIM2_HUMAN
NC score	-0.000749 (rank : 1571)	θ value	6.88961 (rank : 1322)
Query Neighborhood Hits	1407	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

MYOD1_HUMAN
NC score	-0.000772 (rank : 1572)	θ value	8.99809 (rank : 1378)
Query Neighborhood Hits	1407	Target Neighborhood Hits	100	Shared Neighborhood Hits	15
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

SCAP_HUMAN
NC score	-0.000799 (rank : 1573)	θ value	0.47712 (rank : 930)
Query Neighborhood Hits	1407	Target Neighborhood Hits	368	Shared Neighborhood Hits	52
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

UBP30_HUMAN
NC score	-0.001099 (rank : 1574)	θ value	6.88961 (rank : 1333)
Query Neighborhood Hits	1407	Target Neighborhood Hits	94	Shared Neighborhood Hits	14
SwissProt Accessions	Q70CQ3, Q8WTU7, Q96JX4, Q9BSS3	Gene names	USP30
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 30 (EC 3.1.2.15) (Ubiquitin thioesterase 30) (Ubiquitin-specific-processing protease 30) (Deubiquitinating enzyme 30).

ZEP1_HUMAN
NC score	-0.001105 (rank : 1575)	θ value	0.0148317 (rank : 797)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1036	Shared Neighborhood Hits	143
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZHX2_MOUSE
NC score	-0.001266 (rank : 1576)	θ value	5.27518 (rank : 1262)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	51
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

FBLN2_MOUSE
NC score	-0.001267 (rank : 1577)	θ value	0.62314 (rank : 943)
Query Neighborhood Hits	1407	Target Neighborhood Hits	505	Shared Neighborhood Hits	76
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

DDX51_HUMAN
NC score	-0.001327 (rank : 1578)	θ value	4.03905 (rank : 1172)
Query Neighborhood Hits	1407	Target Neighborhood Hits	332	Shared Neighborhood Hits	57
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

PHLPL_HUMAN
NC score	-0.001492 (rank : 1579)	θ value	8.99809 (rank : 1389)
Query Neighborhood Hits	1407	Target Neighborhood Hits	310	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZVD8, Q9NV17, Q9Y2E3	Gene names	PHLPPL, KIAA0931
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat protein phosphatase-like (EC 3.1.3.16).

PCOC1_HUMAN
NC score	-0.001661 (rank : 1580)	θ value	1.38821 (rank : 1029)
Query Neighborhood Hits	1407	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

FOXK2_HUMAN
NC score	-0.001767 (rank : 1581)	θ value	8.99809 (rank : 1358)
Query Neighborhood Hits	1407	Target Neighborhood Hits	190	Shared Neighborhood Hits	47
SwissProt Accessions	Q01167, Q13622, Q13623, Q13624	Gene names	FOXK2, ILF, ILF1
Domain Architecture
Description	Forkhead box protein K2 (Interleukin enhancer-binding factor 1) (Cellular transcription factor ILF-1).

ZEP1_MOUSE
NC score	-0.001822 (rank : 1582)	θ value	0.0252991 (rank : 813)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1063	Shared Neighborhood Hits	154
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

FOXP4_MOUSE
NC score	-0.001917 (rank : 1583)	θ value	5.27518 (rank : 1228)
Query Neighborhood Hits	1407	Target Neighborhood Hits	211	Shared Neighborhood Hits	46
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

FOXN4_HUMAN
NC score	-0.001948 (rank : 1584)	θ value	1.06291 (rank : 983)
Query Neighborhood Hits	1407	Target Neighborhood Hits	248	Shared Neighborhood Hits	56
SwissProt Accessions	Q96NZ1, Q6ZMR4, Q96NZ0	Gene names	FOXN4
Domain Architecture	No domain graphic available
Description	Forkhead box protein N4.

IC1_MOUSE
NC score	-0.002068 (rank : 1585)	θ value	0.62314 (rank : 945)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	36
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

LYL1_HUMAN
NC score	-0.002116 (rank : 1586)	θ value	6.88961 (rank : 1305)
Query Neighborhood Hits	1407	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

TRPC6_MOUSE
NC score	-0.002149 (rank : 1587)	θ value	6.88961 (rank : 1331)
Query Neighborhood Hits	1407	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

ZFHX2_HUMAN
NC score	-0.002323 (rank : 1588)	θ value	1.38821 (rank : 1044)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1178	Shared Neighborhood Hits	161
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

PTN13_MOUSE
NC score	-0.002683 (rank : 1589)	θ value	2.36792 (rank : 1120)
Query Neighborhood Hits	1407	Target Neighborhood Hits	426	Shared Neighborhood Hits	60
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

ZN687_HUMAN
NC score	-0.003048 (rank : 1590)	θ value	0.163984 (rank : 861)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1244	Shared Neighborhood Hits	224
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

PARC_MOUSE
NC score	-0.003179 (rank : 1591)	θ value	8.99809 (rank : 1386)
Query Neighborhood Hits	1407	Target Neighborhood Hits	114	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

LRP3_HUMAN
NC score	-0.003261 (rank : 1592)	θ value	6.88961 (rank : 1302)
Query Neighborhood Hits	1407	Target Neighborhood Hits	280	Shared Neighborhood Hits	47
SwissProt Accessions	O75074	Gene names	LRP3
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 3 precursor (hLRp105).

KCD12_MOUSE
NC score	-0.003399 (rank : 1593)	θ value	8.99809 (rank : 1373)
Query Neighborhood Hits	1407	Target Neighborhood Hits	66	Shared Neighborhood Hits	9
SwissProt Accessions	Q6WVG3	Gene names	Kctd12, Pfet1
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain).

KCNC3_MOUSE
NC score	-0.003725 (rank : 1594)	θ value	5.27518 (rank : 1234)
Query Neighborhood Hits	1407	Target Neighborhood Hits	173	Shared Neighborhood Hits	33
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

FOXO4_HUMAN
NC score	-0.003808 (rank : 1595)	θ value	8.99809 (rank : 1360)
Query Neighborhood Hits	1407	Target Neighborhood Hits	197	Shared Neighborhood Hits	42
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

PCD15_MOUSE
NC score	-0.004047 (rank : 1596)	θ value	8.99809 (rank : 1387)
Query Neighborhood Hits	1407	Target Neighborhood Hits	262	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PJ1	Gene names	Pcdh15
Domain Architecture
Description	Protocadherin-15 precursor.

CAN3_MOUSE
NC score	-0.004382 (rank : 1597)	θ value	5.27518 (rank : 1213)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	Q64691, Q9WUC5	Gene names	Capn3
Domain Architecture
Description	Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).

FOXQ1_HUMAN
NC score	-0.004791 (rank : 1598)	θ value	6.88961 (rank : 1291)
Query Neighborhood Hits	1407	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

IRX6_MOUSE
NC score	-0.004796 (rank : 1599)	θ value	5.27518 (rank : 1231)
Query Neighborhood Hits	1407	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER75	Gene names	Irx6, Irxb3
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-6 (Iroquois homeobox protein 6) (Homeodomain protein IRXB3).

BAI2_MOUSE
NC score	-0.004863 (rank : 1600)	θ value	0.365318 (rank : 899)
Query Neighborhood Hits	1407	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

TLE1_MOUSE
NC score	-0.005114 (rank : 1601)	θ value	3.0926 (rank : 1158)
Query Neighborhood Hits	1407	Target Neighborhood Hits	491	Shared Neighborhood Hits	81
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

HXD3_HUMAN
NC score	-0.005919 (rank : 1602)	θ value	0.0563607 (rank : 827)
Query Neighborhood Hits	1407	Target Neighborhood Hits	433	Shared Neighborhood Hits	60
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

SALL3_HUMAN
NC score	-0.006371 (rank : 1603)	θ value	2.36792 (rank : 1122)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1066	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TSH3_HUMAN
NC score	-0.006400 (rank : 1604)	θ value	4.03905 (rank : 1204)
Query Neighborhood Hits	1407	Target Neighborhood Hits	564	Shared Neighborhood Hits	41
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

HXD3_MOUSE
NC score	-0.006553 (rank : 1605)	θ value	0.279714 (rank : 887)
Query Neighborhood Hits	1407	Target Neighborhood Hits	435	Shared Neighborhood Hits	60
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

PCD16_HUMAN
NC score	-0.006671 (rank : 1606)	θ value	1.81305 (rank : 1070)
Query Neighborhood Hits	1407	Target Neighborhood Hits	245	Shared Neighborhood Hits	35
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

FLRT2_HUMAN
NC score	-0.006703 (rank : 1607)	θ value	4.03905 (rank : 1176)
Query Neighborhood Hits	1407	Target Neighborhood Hits	295	Shared Neighborhood Hits	27
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

TMPSD_HUMAN
NC score	-0.006926 (rank : 1608)	θ value	4.03905 (rank : 1203)
Query Neighborhood Hits	1407	Target Neighborhood Hits	333	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

LTB1L_HUMAN
NC score	-0.007169 (rank : 1609)	θ value	6.88961 (rank : 1303)
Query Neighborhood Hits	1407	Target Neighborhood Hits	553	Shared Neighborhood Hits	68
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

CDX1_MOUSE
NC score	-0.007371 (rank : 1610)	θ value	8.99809 (rank : 1345)
Query Neighborhood Hits	1407	Target Neighborhood Hits	379	Shared Neighborhood Hits	60
SwissProt Accessions	P18111, Q8VCF7	Gene names	Cdx1, Cdx-1
Domain Architecture
Description	Homeobox protein CDX-1 (Caudal-type homeobox protein 1).

ZN687_MOUSE
NC score	-0.007914 (rank : 1611)	θ value	0.47712 (rank : 939)
Query Neighborhood Hits	1407	Target Neighborhood Hits	913	Shared Neighborhood Hits	131
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

PCDH8_HUMAN
NC score	-0.008126 (rank : 1612)	θ value	1.81305 (rank : 1072)
Query Neighborhood Hits	1407	Target Neighborhood Hits	164	Shared Neighborhood Hits	15
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

ATS16_HUMAN
NC score	-0.008218 (rank : 1613)	θ value	6.88961 (rank : 1268)
Query Neighborhood Hits	1407	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

PAX3_MOUSE
NC score	-0.008629 (rank : 1614)	θ value	5.27518 (rank : 1240)
Query Neighborhood Hits	1407	Target Neighborhood Hits	478	Shared Neighborhood Hits	60
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

HME1_MOUSE
NC score	-0.008700 (rank : 1615)	θ value	8.99809 (rank : 1366)
Query Neighborhood Hits	1407	Target Neighborhood Hits	397	Shared Neighborhood Hits	50
SwissProt Accessions	P09065	Gene names	En1, En-1
Domain Architecture
Description	Homeobox protein engrailed-1 (Mo-En-1).

PCDGK_HUMAN
NC score	-0.009012 (rank : 1616)	θ value	1.81305 (rank : 1071)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UN70, O60622, Q08192, Q9Y5C4	Gene names	PCDHGC3, PCDH2
Domain Architecture
Description	Protocadherin gamma C3 precursor (PCDH-gamma-C3) (Protocadherin 43) (PC-43) (Protocadherin 2).

ZEP2_MOUSE
NC score	-0.009441 (rank : 1617)	θ value	8.99809 (rank : 1405)
Query Neighborhood Hits	1407	Target Neighborhood Hits	964	Shared Neighborhood Hits	136
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

PCDGI_HUMAN
NC score	-0.009712 (rank : 1618)	θ value	8.99809 (rank : 1388)
Query Neighborhood Hits	1407	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y5F9, Q9Y5C5	Gene names	PCDHGB6
Domain Architecture
Description	Protocadherin gamma B6 precursor (PCDH-gamma-B6).

PAX7_HUMAN
NC score	-0.010214 (rank : 1619)	θ value	5.27518 (rank : 1241)
Query Neighborhood Hits	1407	Target Neighborhood Hits	456	Shared Neighborhood Hits	52
SwissProt Accessions	P23759	Gene names	PAX7, HUP1
Domain Architecture
Description	Paired box protein Pax-7 (HUP1).

KBTB9_HUMAN
NC score	-0.010854 (rank : 1620)	θ value	8.99809 (rank : 1372)
Query Neighborhood Hits	1407	Target Neighborhood Hits	192	Shared Neighborhood Hits	12
SwissProt Accessions	Q96CT2, Q8N388, Q96BF0, Q96PW7	Gene names	KBTBD9, KIAA1921
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 9.

DLX4_HUMAN
NC score	-0.011499 (rank : 1621)	θ value	4.03905 (rank : 1174)
Query Neighborhood Hits	1407	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q92988, O60480, Q13265, Q6PJK0, Q9HBE0	Gene names	DLX4, BP1, DLX7, DLX8
Domain Architecture	No domain graphic available
Description	Homeobox protein DLX-4 (DLX-7) (DLX-8) (Beta protein 1).

PAX7_MOUSE
NC score	-0.011717 (rank : 1622)	θ value	5.27518 (rank : 1242)
Query Neighborhood Hits	1407	Target Neighborhood Hits	422	Shared Neighborhood Hits	38
SwissProt Accessions	P47239, Q9ES16	Gene names	Pax7, Pax-7
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-7.

KLF17_HUMAN
NC score	-0.012103 (rank : 1623)	θ value	0.0330416 (rank : 817)
Query Neighborhood Hits	1407	Target Neighborhood Hits	882	Shared Neighborhood Hits	128
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

EVX1_HUMAN
NC score	-0.012598 (rank : 1624)	θ value	4.03905 (rank : 1175)
Query Neighborhood Hits	1407	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

TRYD_HUMAN
NC score	-0.012962 (rank : 1625)	θ value	8.99809 (rank : 1402)
Query Neighborhood Hits	1407	Target Neighborhood Hits	175	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZJ3, O95824, Q8TDI6, Q96L36, Q96RZ5, Q9H2Y6, Q9UQI8	Gene names	TPSD1
Domain Architecture
Description	Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).

TRYA1_HUMAN
NC score	-0.013268 (rank : 1626)	θ value	8.99809 (rank : 1401)
Query Neighborhood Hits	1407	Target Neighborhood Hits	177	Shared Neighborhood Hits	4
SwissProt Accessions	P15157, Q9H2Y5, Q9UQI1	Gene names	TPSAB1, TPS1
Domain Architecture
Description	Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).

CELR1_MOUSE
NC score	-0.013317 (rank : 1627)	θ value	1.38821 (rank : 1006)
Query Neighborhood Hits	1407	Target Neighborhood Hits	617	Shared Neighborhood Hits	42
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

ZN516_MOUSE
NC score	-0.013488 (rank : 1628)	θ value	4.03905 (rank : 1207)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1197	Shared Neighborhood Hits	202
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

GLI2_HUMAN
NC score	-0.013881 (rank : 1629)	θ value	1.06291 (rank : 984)
Query Neighborhood Hits	1407	Target Neighborhood Hits	971	Shared Neighborhood Hits	136
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

LV2H_HUMAN
NC score	-0.014119 (rank : 1630)	θ value	6.88961 (rank : 1304)
Query Neighborhood Hits	1407	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	P01711	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region VIL.

GLIS3_MOUSE
NC score	-0.014543 (rank : 1631)	θ value	1.38821 (rank : 1015)
Query Neighborhood Hits	1407	Target Neighborhood Hits	861	Shared Neighborhood Hits	109
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

GLI3_HUMAN
NC score	-0.015817 (rank : 1632)	θ value	0.47712 (rank : 927)
Query Neighborhood Hits	1407	Target Neighborhood Hits	871	Shared Neighborhood Hits	102
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

SP5_MOUSE
NC score	-0.015959 (rank : 1633)	θ value	0.163984 (rank : 858)
Query Neighborhood Hits	1407	Target Neighborhood Hits	821	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

ZIC5_HUMAN
NC score	-0.016216 (rank : 1634)	θ value	2.36792 (rank : 1129)
Query Neighborhood Hits	1407	Target Neighborhood Hits	774	Shared Neighborhood Hits	88
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

SP5_HUMAN
NC score	-0.016287 (rank : 1635)	θ value	0.21417 (rank : 875)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	91
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

ZN217_HUMAN
NC score	-0.016436 (rank : 1636)	θ value	0.813845 (rank : 975)
Query Neighborhood Hits	1407	Target Neighborhood Hits	905	Shared Neighborhood Hits	112
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

ZBT45_HUMAN
NC score	-0.016817 (rank : 1637)	θ value	1.06291 (rank : 1003)
Query Neighborhood Hits	1407	Target Neighborhood Hits	901	Shared Neighborhood Hits	121
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

KLF10_HUMAN
NC score	-0.017062 (rank : 1638)	θ value	3.0926 (rank : 1144)
Query Neighborhood Hits	1407	Target Neighborhood Hits	744	Shared Neighborhood Hits	72
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

EGR1_MOUSE
NC score	-0.017663 (rank : 1639)	θ value	1.06291 (rank : 981)
Query Neighborhood Hits	1407	Target Neighborhood Hits	816	Shared Neighborhood Hits	85
SwissProt Accessions	P08046, Q61777	Gene names	Egr1, Egr-1, Krox-24
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A).

GLIS1_MOUSE
NC score	-0.017838 (rank : 1640)	θ value	1.81305 (rank : 1060)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K1M4, Q6NZF6, Q8R4Z3	Gene names	Glis1, Gli5
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1) (Gli homologous protein 1) (GliH1).

PRD16_HUMAN
NC score	-0.018403 (rank : 1641)	θ value	1.06291 (rank : 995)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

EGR3_MOUSE
NC score	-0.018530 (rank : 1642)	θ value	1.38821 (rank : 1011)
Query Neighborhood Hits	1407	Target Neighborhood Hits	747	Shared Neighborhood Hits	63
SwissProt Accessions	P43300, Q9R276	Gene names	Egr3, Egr-3
Domain Architecture
Description	Early growth response protein 3 (EGR-3).

EGR3_HUMAN
NC score	-0.018543 (rank : 1643)	θ value	1.38821 (rank : 1010)
Query Neighborhood Hits	1407	Target Neighborhood Hits	746	Shared Neighborhood Hits	63
SwissProt Accessions	Q06889	Gene names	EGR3, PILOT
Domain Architecture	No domain graphic available
Description	Early growth response protein 3 (EGR-3) (Zinc finger protein pilot).

KLF13_HUMAN
NC score	-0.018580 (rank : 1644)	θ value	8.99809 (rank : 1374)
Query Neighborhood Hits	1407	Target Neighborhood Hits	739	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y2Y9, Q9Y356	Gene names	KLF13, BTEB3, NSLP1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor NSLP1) (Novel Sp1-like zinc finger transcription factor 1).

KLF16_MOUSE
NC score	-0.018710 (rank : 1645)	θ value	0.365318 (rank : 911)
Query Neighborhood Hits	1407	Target Neighborhood Hits	719	Shared Neighborhood Hits	52
SwissProt Accessions	P58334, Q3U3Y4, Q8C8S2	Gene names	Klf16, Bteb4, Drrf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Dopamine receptor-regulating factor).

KLF5_MOUSE
NC score	-0.018867 (rank : 1646)	θ value	6.88961 (rank : 1300)
Query Neighborhood Hits	1407	Target Neighborhood Hits	726	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0Z7, Q9JMI2	Gene names	Klf5, Bteb2, Iklf
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2).

SIP1_HUMAN
NC score	-0.019009 (rank : 1647)	θ value	1.06291 (rank : 998)
Query Neighborhood Hits	1407	Target Neighborhood Hits	832	Shared Neighborhood Hits	68
SwissProt Accessions	O60315, Q9UED1	Gene names	ZFHX1B, KIAA0569, SIP1, ZFX1B
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1) (SMADIP1).

ZN692_MOUSE
NC score	-0.019436 (rank : 1648)	θ value	1.38821 (rank : 1045)
Query Neighborhood Hits	1407	Target Neighborhood Hits	751	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

EVI1_MOUSE
NC score	-0.019640 (rank : 1649)	θ value	5.27518 (rank : 1227)
Query Neighborhood Hits	1407	Target Neighborhood Hits	826	Shared Neighborhood Hits	75
SwissProt Accessions	P14404	Gene names	Evi1, Evi-1
Domain Architecture	No domain graphic available
Description	Ecotropic virus integration 1 site protein.

MAZ_HUMAN
NC score	-0.019934 (rank : 1650)	θ value	4.03905 (rank : 1186)
Query Neighborhood Hits	1407	Target Neighborhood Hits	757	Shared Neighborhood Hits	71
SwissProt Accessions	P56270, Q15703, Q99443	Gene names	MAZ
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1) (ZF87) (ZIF87).

MAZ_MOUSE
NC score	-0.020487 (rank : 1651)	θ value	5.27518 (rank : 1237)
Query Neighborhood Hits	1407	Target Neighborhood Hits	745	Shared Neighborhood Hits	64
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).

ZN710_HUMAN
NC score	-0.020502 (rank : 1652)	θ value	0.62314 (rank : 955)
Query Neighborhood Hits	1407	Target Neighborhood Hits	796	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N1W2, Q6ZMK9, Q8NDU0	Gene names	ZNF710
Domain Architecture	No domain graphic available
Description	Zinc finger protein 710.

ZN509_MOUSE
NC score	-0.021068 (rank : 1653)	θ value	6.88961 (rank : 1336)
Query Neighborhood Hits	1407	Target Neighborhood Hits	990	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

IKAR_MOUSE
NC score	-0.021212 (rank : 1654)	θ value	8.99809 (rank : 1368)
Query Neighborhood Hits	1407	Target Neighborhood Hits	734	Shared Neighborhood Hits	47
SwissProt Accessions	Q03267, Q64044, Q64045, Q64051	Gene names	Ikzf1, Ikaros, Lyf1, Zfpn1a1, Znfn1a1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

ZN263_HUMAN
NC score	-0.022256 (rank : 1655)	θ value	5.27518 (rank : 1264)
Query Neighborhood Hits	1407	Target Neighborhood Hits	795	Shared Neighborhood Hits	53
SwissProt Accessions	O14978, O43387, Q96H95	Gene names	ZNF263, FPM315
Domain Architecture
Description	Zinc finger protein 263 (Zinc finger protein FPM315).

ZBT16_HUMAN
NC score	-0.022277 (rank : 1656)	θ value	1.06291 (rank : 1002)
Query Neighborhood Hits	1407	Target Neighborhood Hits	1010	Shared Neighborhood Hits	96
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

ZN235_MOUSE
NC score	-0.022533 (rank : 1657)	θ value	5.27518 (rank : 1263)
Query Neighborhood Hits	1407	Target Neighborhood Hits	768	Shared Neighborhood Hits	52
SwissProt Accessions	Q61116, Q3UKA3, Q8CE70	Gene names	Znf235, Zfp93
Domain Architecture
Description	Zinc finger protein 235 (Zinc finger protein 93) (Zfp-93).