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Network neighborhood for query Sequence : DCC_HUMAN

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DCC_HUMAN
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DCC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	583	Target Neighborhood Hits	583	Shared Neighborhood Hits	583
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	0 (rank : 2)	NC score	0.980641 (rank : 2)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	548
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NEO1_HUMAN
θ value	0 (rank : 3)	NC score	0.976628 (rank : 3)
Query Neighborhood Hits	583	Target Neighborhood Hits	530	Shared Neighborhood Hits	410
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	0 (rank : 4)	NC score	0.975594 (rank : 4)
Query Neighborhood Hits	583	Target Neighborhood Hits	523	Shared Neighborhood Hits	410
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DSCL1_HUMAN
θ value	4.37348e-71 (rank : 5)	NC score	0.930405 (rank : 6)
Query Neighborhood Hits	583	Target Neighborhood Hits	589	Shared Neighborhood Hits	417
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

PTPRD_HUMAN
θ value	1.66191e-70 (rank : 6)	NC score	0.737436 (rank : 75)
Query Neighborhood Hits	583	Target Neighborhood Hits	485	Shared Neighborhood Hits	363
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PUNC_HUMAN
θ value	5.91091e-68 (rank : 7)	NC score	0.922211 (rank : 9)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	354
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

DSCAM_HUMAN
θ value	1.00825e-67 (rank : 8)	NC score	0.931651 (rank : 5)
Query Neighborhood Hits	583	Target Neighborhood Hits	524	Shared Neighborhood Hits	410
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

PUNC_MOUSE
θ value	2.24614e-67 (rank : 9)	NC score	0.917808 (rank : 12)
Query Neighborhood Hits	583	Target Neighborhood Hits	501	Shared Neighborhood Hits	349
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

SDK1_MOUSE
θ value	2.24614e-67 (rank : 10)	NC score	0.920196 (rank : 11)
Query Neighborhood Hits	583	Target Neighborhood Hits	495	Shared Neighborhood Hits	406
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_HUMAN
θ value	2.93355e-67 (rank : 11)	NC score	0.921132 (rank : 10)
Query Neighborhood Hits	583	Target Neighborhood Hits	511	Shared Neighborhood Hits	407
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_MOUSE
θ value	1.90147e-66 (rank : 12)	NC score	0.922673 (rank : 8)
Query Neighborhood Hits	583	Target Neighborhood Hits	480	Shared Neighborhood Hits	402
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

PTPRD_MOUSE
θ value	2.4834e-66 (rank : 13)	NC score	0.748564 (rank : 69)
Query Neighborhood Hits	583	Target Neighborhood Hits	491	Shared Neighborhood Hits	370
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SDK2_HUMAN
θ value	5.17823e-64 (rank : 14)	NC score	0.924106 (rank : 7)
Query Neighborhood Hits	583	Target Neighborhood Hits	495	Shared Neighborhood Hits	404
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

L1CAM_HUMAN
θ value	1.19377e-60 (rank : 15)	NC score	0.912396 (rank : 13)
Query Neighborhood Hits	583	Target Neighborhood Hits	457	Shared Neighborhood Hits	388
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PTPRF_HUMAN
θ value	7.24236e-58 (rank : 16)	NC score	0.742998 (rank : 73)
Query Neighborhood Hits	583	Target Neighborhood Hits	489	Shared Neighborhood Hits	374
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

CHL1_HUMAN
θ value	6.77864e-56 (rank : 17)	NC score	0.896747 (rank : 23)
Query Neighborhood Hits	583	Target Neighborhood Hits	413	Shared Neighborhood Hits	367
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

L1CAM_MOUSE
θ value	3.36421e-55 (rank : 18)	NC score	0.908165 (rank : 17)
Query Neighborhood Hits	583	Target Neighborhood Hits	457	Shared Neighborhood Hits	388
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PTPRS_HUMAN
θ value	3.36421e-55 (rank : 19)	NC score	0.728141 (rank : 76)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	358
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

NRCAM_HUMAN
θ value	1.08223e-53 (rank : 20)	NC score	0.910815 (rank : 15)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	381
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROBO3_HUMAN
θ value	5.93839e-52 (rank : 21)	NC score	0.902781 (rank : 18)
Query Neighborhood Hits	583	Target Neighborhood Hits	570	Shared Neighborhood Hits	400
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

NRCAM_MOUSE
θ value	7.75577e-52 (rank : 22)	NC score	0.911783 (rank : 14)
Query Neighborhood Hits	583	Target Neighborhood Hits	432	Shared Neighborhood Hits	374
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NFASC_HUMAN
θ value	1.72781e-51 (rank : 23)	NC score	0.908678 (rank : 16)
Query Neighborhood Hits	583	Target Neighborhood Hits	497	Shared Neighborhood Hits	394
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

ROBO2_HUMAN
θ value	1.72781e-51 (rank : 24)	NC score	0.901760 (rank : 20)
Query Neighborhood Hits	583	Target Neighborhood Hits	479	Shared Neighborhood Hits	387
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO1_MOUSE
θ value	2.94719e-51 (rank : 25)	NC score	0.894856 (rank : 26)
Query Neighborhood Hits	583	Target Neighborhood Hits	559	Shared Neighborhood Hits	391
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO1_HUMAN
θ value	3.84914e-51 (rank : 26)	NC score	0.890777 (rank : 29)
Query Neighborhood Hits	583	Target Neighborhood Hits	529	Shared Neighborhood Hits	382
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO3_MOUSE
θ value	3.84914e-51 (rank : 27)	NC score	0.901833 (rank : 19)
Query Neighborhood Hits	583	Target Neighborhood Hits	524	Shared Neighborhood Hits	391
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

ROBO2_MOUSE
θ value	1.91031e-50 (rank : 28)	NC score	0.901626 (rank : 21)
Query Neighborhood Hits	583	Target Neighborhood Hits	504	Shared Neighborhood Hits	402
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CNTN4_HUMAN
θ value	1.36902e-48 (rank : 29)	NC score	0.888498 (rank : 31)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	382
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CHL1_MOUSE
θ value	8.87376e-48 (rank : 30)	NC score	0.888796 (rank : 30)
Query Neighborhood Hits	583	Target Neighborhood Hits	402	Shared Neighborhood Hits	364
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN4_MOUSE
θ value	8.87376e-48 (rank : 31)	NC score	0.888155 (rank : 33)
Query Neighborhood Hits	583	Target Neighborhood Hits	445	Shared Neighborhood Hits	384
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN6_HUMAN
θ value	4.86918e-46 (rank : 32)	NC score	0.882813 (rank : 37)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	370
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

BOC_HUMAN
θ value	2.04573e-44 (rank : 33)	NC score	0.882547 (rank : 38)
Query Neighborhood Hits	583	Target Neighborhood Hits	543	Shared Neighborhood Hits	357
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CNTN6_MOUSE
θ value	5.95217e-44 (rank : 34)	NC score	0.881244 (rank : 39)
Query Neighborhood Hits	583	Target Neighborhood Hits	429	Shared Neighborhood Hits	375
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTN5_HUMAN
θ value	6.58091e-43 (rank : 35)	NC score	0.895337 (rank : 25)
Query Neighborhood Hits	583	Target Neighborhood Hits	446	Shared Neighborhood Hits	394
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTN3_HUMAN
θ value	2.50074e-42 (rank : 36)	NC score	0.893380 (rank : 28)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	395
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

NFASC_MOUSE
θ value	3.26607e-42 (rank : 37)	NC score	0.900938 (rank : 22)
Query Neighborhood Hits	583	Target Neighborhood Hits	475	Shared Neighborhood Hits	391
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

CNTN3_MOUSE
θ value	6.15952e-41 (rank : 38)	NC score	0.887955 (rank : 34)
Query Neighborhood Hits	583	Target Neighborhood Hits	447	Shared Neighborhood Hits	387
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

BOC_MOUSE
θ value	1.05066e-40 (rank : 39)	NC score	0.877478 (rank : 40)
Query Neighborhood Hits	583	Target Neighborhood Hits	433	Shared Neighborhood Hits	341
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CNTN5_MOUSE
θ value	2.58786e-39 (rank : 40)	NC score	0.888259 (rank : 32)
Query Neighborhood Hits	583	Target Neighborhood Hits	434	Shared Neighborhood Hits	382
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

HMCN1_HUMAN
θ value	1.85459e-37 (rank : 41)	NC score	0.615906 (rank : 119)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	377
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

CNTN2_HUMAN
θ value	1.73584e-35 (rank : 42)	NC score	0.895640 (rank : 24)
Query Neighborhood Hits	583	Target Neighborhood Hits	440	Shared Neighborhood Hits	393
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN1_HUMAN
θ value	2.96089e-35 (rank : 43)	NC score	0.883167 (rank : 36)
Query Neighborhood Hits	583	Target Neighborhood Hits	431	Shared Neighborhood Hits	379
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN1_MOUSE
θ value	3.27365e-34 (rank : 44)	NC score	0.883627 (rank : 35)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	381
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_MOUSE
θ value	6.82597e-32 (rank : 45)	NC score	0.893756 (rank : 27)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	392
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

NCA12_HUMAN
θ value	8.91499e-32 (rank : 46)	NC score	0.836827 (rank : 46)
Query Neighborhood Hits	583	Target Neighborhood Hits	437	Shared Neighborhood Hits	363
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA11_HUMAN
θ value	1.16434e-31 (rank : 47)	NC score	0.843799 (rank : 45)
Query Neighborhood Hits	583	Target Neighborhood Hits	443	Shared Neighborhood Hits	368
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

TITIN_HUMAN
θ value	2.59387e-31 (rank : 48)	NC score	0.553886 (rank : 145)
Query Neighborhood Hits	583	Target Neighborhood Hits	2923	Shared Neighborhood Hits	498
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NCA12_MOUSE
θ value	1.08979e-29 (rank : 49)	NC score	0.836738 (rank : 47)
Query Neighborhood Hits	583	Target Neighborhood Hits	399	Shared Neighborhood Hits	350
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCAM2_MOUSE
θ value	1.85889e-29 (rank : 50)	NC score	0.867085 (rank : 41)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	400
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCA11_MOUSE
θ value	3.17079e-29 (rank : 51)	NC score	0.824646 (rank : 48)
Query Neighborhood Hits	583	Target Neighborhood Hits	661	Shared Neighborhood Hits	383
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CDON_MOUSE
θ value	1.57365e-28 (rank : 52)	NC score	0.866702 (rank : 42)
Query Neighborhood Hits	583	Target Neighborhood Hits	410	Shared Neighborhood Hits	347
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_HUMAN
θ value	1.73987e-27 (rank : 53)	NC score	0.865779 (rank : 43)
Query Neighborhood Hits	583	Target Neighborhood Hits	412	Shared Neighborhood Hits	345
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

USH2A_MOUSE
θ value	1.73987e-27 (rank : 54)	NC score	0.418674 (rank : 183)
Query Neighborhood Hits	583	Target Neighborhood Hits	626	Shared Neighborhood Hits	181
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

SPEG_MOUSE
θ value	7.30988e-26 (rank : 55)	NC score	0.396758 (rank : 197)
Query Neighborhood Hits	583	Target Neighborhood Hits	1959	Shared Neighborhood Hits	398
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

NCAM2_HUMAN
θ value	1.62847e-25 (rank : 56)	NC score	0.858601 (rank : 44)
Query Neighborhood Hits	583	Target Neighborhood Hits	441	Shared Neighborhood Hits	389
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

SPEG_HUMAN
θ value	2.12685e-25 (rank : 57)	NC score	0.392243 (rank : 199)
Query Neighborhood Hits	583	Target Neighborhood Hits	1762	Shared Neighborhood Hits	370
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

USH2A_HUMAN
θ value	6.18819e-25 (rank : 58)	NC score	0.434107 (rank : 175)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	187
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

LRIG2_HUMAN
θ value	1.5242e-23 (rank : 59)	NC score	0.603220 (rank : 125)
Query Neighborhood Hits	583	Target Neighborhood Hits	595	Shared Neighborhood Hits	312
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

LRIG1_MOUSE
θ value	3.39556e-23 (rank : 60)	NC score	0.594073 (rank : 131)
Query Neighborhood Hits	583	Target Neighborhood Hits	627	Shared Neighborhood Hits	313
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYLK_MOUSE
θ value	3.39556e-23 (rank : 61)	NC score	0.397032 (rank : 196)
Query Neighborhood Hits	583	Target Neighborhood Hits	1489	Shared Neighborhood Hits	392
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PGBM_HUMAN
θ value	3.39556e-23 (rank : 62)	NC score	0.616404 (rank : 118)
Query Neighborhood Hits	583	Target Neighborhood Hits	1113	Shared Neighborhood Hits	385
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

MYLK_HUMAN
θ value	9.87957e-23 (rank : 63)	NC score	0.399387 (rank : 192)
Query Neighborhood Hits	583	Target Neighborhood Hits	1328	Shared Neighborhood Hits	371
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYPN_HUMAN
θ value	1.29031e-22 (rank : 64)	NC score	0.794132 (rank : 52)
Query Neighborhood Hits	583	Target Neighborhood Hits	418	Shared Neighborhood Hits	294
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MUSK_MOUSE
θ value	1.6852e-22 (rank : 65)	NC score	0.468042 (rank : 162)
Query Neighborhood Hits	583	Target Neighborhood Hits	1057	Shared Neighborhood Hits	338
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYOM1_HUMAN
θ value	2.87452e-22 (rank : 66)	NC score	0.770591 (rank : 59)
Query Neighborhood Hits	583	Target Neighborhood Hits	405	Shared Neighborhood Hits	315
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

PTK7_HUMAN
θ value	2.87452e-22 (rank : 67)	NC score	0.504585 (rank : 153)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	356
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

LRIG2_MOUSE
θ value	3.75424e-22 (rank : 68)	NC score	0.599620 (rank : 128)
Query Neighborhood Hits	583	Target Neighborhood Hits	586	Shared Neighborhood Hits	309
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

MUSK_HUMAN
θ value	3.75424e-22 (rank : 69)	NC score	0.467033 (rank : 164)
Query Neighborhood Hits	583	Target Neighborhood Hits	1074	Shared Neighborhood Hits	342
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MYPN_MOUSE
θ value	8.36355e-22 (rank : 70)	NC score	0.785175 (rank : 57)
Query Neighborhood Hits	583	Target Neighborhood Hits	421	Shared Neighborhood Hits	288
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

LRIG1_HUMAN
θ value	2.43343e-21 (rank : 71)	NC score	0.604665 (rank : 124)
Query Neighborhood Hits	583	Target Neighborhood Hits	654	Shared Neighborhood Hits	317
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYOM2_HUMAN
θ value	3.17815e-21 (rank : 72)	NC score	0.778021 (rank : 58)
Query Neighborhood Hits	583	Target Neighborhood Hits	341	Shared Neighborhood Hits	301
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

FINC_MOUSE
θ value	4.15078e-21 (rank : 73)	NC score	0.565915 (rank : 140)
Query Neighborhood Hits	583	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

LRIG3_MOUSE
θ value	1.2077e-20 (rank : 74)	NC score	0.577434 (rank : 136)
Query Neighborhood Hits	583	Target Neighborhood Hits	611	Shared Neighborhood Hits	314
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

LRIG3_HUMAN
θ value	1.5773e-20 (rank : 75)	NC score	0.571247 (rank : 138)
Query Neighborhood Hits	583	Target Neighborhood Hits	601	Shared Neighborhood Hits	311
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

PGBM_MOUSE
θ value	1.5773e-20 (rank : 76)	NC score	0.602947 (rank : 126)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	374
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

OBSL1_HUMAN
θ value	5.99374e-20 (rank : 77)	NC score	0.814468 (rank : 49)
Query Neighborhood Hits	583	Target Neighborhood Hits	354	Shared Neighborhood Hits	288
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

FINC_HUMAN
θ value	2.97466e-19 (rank : 78)	NC score	0.559342 (rank : 143)
Query Neighborhood Hits	583	Target Neighborhood Hits	302	Shared Neighborhood Hits	183
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

FNDC3_HUMAN
θ value	5.07402e-19 (rank : 79)	NC score	0.694668 (rank : 82)
Query Neighborhood Hits	583	Target Neighborhood Hits	196	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

TYRO3_HUMAN
θ value	8.65492e-19 (rank : 80)	NC score	0.365520 (rank : 214)
Query Neighborhood Hits	583	Target Neighborhood Hits	995	Shared Neighborhood Hits	286
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	1.13037e-18 (rank : 81)	NC score	0.363466 (rank : 217)
Query Neighborhood Hits	583	Target Neighborhood Hits	1007	Shared Neighborhood Hits	295
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

MYOM1_MOUSE
θ value	2.5182e-18 (rank : 82)	NC score	0.766304 (rank : 62)
Query Neighborhood Hits	583	Target Neighborhood Hits	415	Shared Neighborhood Hits	329
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

OBSCN_HUMAN
θ value	2.5182e-18 (rank : 83)	NC score	0.412137 (rank : 186)
Query Neighborhood Hits	583	Target Neighborhood Hits	1931	Shared Neighborhood Hits	423
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ROBO4_HUMAN
θ value	3.28887e-18 (rank : 84)	NC score	0.796166 (rank : 50)
Query Neighborhood Hits	583	Target Neighborhood Hits	364	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

PTPRT_MOUSE
θ value	1.63225e-17 (rank : 85)	NC score	0.356081 (rank : 223)
Query Neighborhood Hits	583	Target Neighborhood Hits	219	Shared Neighborhood Hits	142
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

FGRL1_HUMAN
θ value	2.13179e-17 (rank : 86)	NC score	0.792314 (rank : 53)
Query Neighborhood Hits	583	Target Neighborhood Hits	335	Shared Neighborhood Hits	284
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

PTPRT_HUMAN
θ value	4.74913e-17 (rank : 87)	NC score	0.354913 (rank : 225)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	141
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

MYPC2_MOUSE
θ value	8.10077e-17 (rank : 88)	NC score	0.702673 (rank : 79)
Query Neighborhood Hits	583	Target Neighborhood Hits	297	Shared Neighborhood Hits	271
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

COCA1_HUMAN
θ value	1.058e-16 (rank : 89)	NC score	0.424923 (rank : 180)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

FGRL1_MOUSE
θ value	1.80466e-16 (rank : 90)	NC score	0.789035 (rank : 56)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	292
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

MYPC2_HUMAN
θ value	2.35696e-16 (rank : 91)	NC score	0.701184 (rank : 80)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	285
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

FNDC3_MOUSE
θ value	3.07829e-16 (rank : 92)	NC score	0.692099 (rank : 84)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	170
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

VGFR1_HUMAN
θ value	5.25075e-16 (rank : 93)	NC score	0.425321 (rank : 179)
Query Neighborhood Hits	583	Target Neighborhood Hits	1109	Shared Neighborhood Hits	341
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

MAMC1_HUMAN
θ value	8.95645e-16 (rank : 94)	NC score	0.768446 (rank : 60)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	301
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
θ value	8.95645e-16 (rank : 95)	NC score	0.767371 (rank : 61)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	301
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

PTPRM_HUMAN
θ value	1.52774e-15 (rank : 96)	NC score	0.385403 (rank : 203)
Query Neighborhood Hits	583	Target Neighborhood Hits	244	Shared Neighborhood Hits	167
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

COCA1_MOUSE
θ value	4.44505e-15 (rank : 97)	NC score	0.438519 (rank : 173)
Query Neighborhood Hits	583	Target Neighborhood Hits	467	Shared Neighborhood Hits	175
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

FGFR3_MOUSE
θ value	7.58209e-15 (rank : 98)	NC score	0.361576 (rank : 219)
Query Neighborhood Hits	583	Target Neighborhood Hits	1059	Shared Neighborhood Hits	307
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR3_HUMAN
θ value	1.29331e-14 (rank : 99)	NC score	0.350931 (rank : 232)
Query Neighborhood Hits	583	Target Neighborhood Hits	1042	Shared Neighborhood Hits	298
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

NPHN_HUMAN
θ value	1.68911e-14 (rank : 100)	NC score	0.762066 (rank : 64)
Query Neighborhood Hits	583	Target Neighborhood Hits	362	Shared Neighborhood Hits	301
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MYPC1_HUMAN
θ value	2.20605e-14 (rank : 101)	NC score	0.703466 (rank : 78)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	273
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

KIRR2_MOUSE
θ value	4.91457e-14 (rank : 102)	NC score	0.685518 (rank : 88)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	255
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

ROBO4_MOUSE
θ value	4.91457e-14 (rank : 103)	NC score	0.795573 (rank : 51)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	280
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

PTPRM_MOUSE
θ value	6.41864e-14 (rank : 104)	NC score	0.380632 (rank : 207)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	164
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

LSAMP_MOUSE
θ value	1.09485e-13 (rank : 105)	NC score	0.764291 (rank : 63)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

FSTL5_MOUSE
θ value	3.18553e-13 (rank : 106)	NC score	0.676816 (rank : 94)
Query Neighborhood Hits	583	Target Neighborhood Hits	355	Shared Neighborhood Hits	258
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

MDGA1_HUMAN
θ value	3.18553e-13 (rank : 107)	NC score	0.758907 (rank : 66)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	300
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MAG_MOUSE
θ value	9.26847e-13 (rank : 108)	NC score	0.692780 (rank : 83)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	252
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MERTK_MOUSE
θ value	9.26847e-13 (rank : 109)	NC score	0.319286 (rank : 261)
Query Neighborhood Hits	583	Target Neighborhood Hits	974	Shared Neighborhood Hits	267
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MYOTI_MOUSE
θ value	9.26847e-13 (rank : 110)	NC score	0.790769 (rank : 54)
Query Neighborhood Hits	583	Target Neighborhood Hits	297	Shared Neighborhood Hits	264
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC3_MOUSE
θ value	1.2105e-12 (rank : 111)	NC score	0.678628 (rank : 91)
Query Neighborhood Hits	583	Target Neighborhood Hits	310	Shared Neighborhood Hits	281
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

OPCM_HUMAN
θ value	1.58096e-12 (rank : 112)	NC score	0.752045 (rank : 67)
Query Neighborhood Hits	583	Target Neighborhood Hits	332	Shared Neighborhood Hits	298
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

VGFR1_MOUSE
θ value	1.58096e-12 (rank : 113)	NC score	0.420634 (rank : 182)
Query Neighborhood Hits	583	Target Neighborhood Hits	1118	Shared Neighborhood Hits	345
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

CO7A1_HUMAN
θ value	2.0648e-12 (rank : 114)	NC score	0.306150 (rank : 276)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	173
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

DUET_HUMAN
θ value	2.0648e-12 (rank : 115)	NC score	0.278610 (rank : 293)
Query Neighborhood Hits	583	Target Neighborhood Hits	1220	Shared Neighborhood Hits	294
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TIE2_HUMAN
θ value	2.0648e-12 (rank : 116)	NC score	0.253506 (rank : 326)
Query Neighborhood Hits	583	Target Neighborhood Hits	1192	Shared Neighborhood Hits	201
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

KIRR1_MOUSE
θ value	3.52202e-12 (rank : 117)	NC score	0.635965 (rank : 112)
Query Neighborhood Hits	583	Target Neighborhood Hits	403	Shared Neighborhood Hits	260
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KIRR2_HUMAN
θ value	3.52202e-12 (rank : 118)	NC score	0.691811 (rank : 85)
Query Neighborhood Hits	583	Target Neighborhood Hits	321	Shared Neighborhood Hits	249
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

MYOTI_HUMAN
θ value	3.52202e-12 (rank : 119)	NC score	0.789148 (rank : 55)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	266
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

LSAMP_HUMAN
θ value	4.59992e-12 (rank : 120)	NC score	0.761636 (rank : 65)
Query Neighborhood Hits	583	Target Neighborhood Hits	347	Shared Neighborhood Hits	302
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

FSTL5_HUMAN
θ value	6.00763e-12 (rank : 121)	NC score	0.680851 (rank : 89)
Query Neighborhood Hits	583	Target Neighborhood Hits	347	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

MUC18_MOUSE
θ value	1.02475e-11 (rank : 122)	NC score	0.653407 (rank : 101)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	233
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

UFO_HUMAN
θ value	1.33837e-11 (rank : 123)	NC score	0.305196 (rank : 277)
Query Neighborhood Hits	583	Target Neighborhood Hits	981	Shared Neighborhood Hits	260
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

TENR_HUMAN
θ value	2.28291e-11 (rank : 124)	NC score	0.346691 (rank : 233)
Query Neighborhood Hits	583	Target Neighborhood Hits	526	Shared Neighborhood Hits	168
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

KIRR1_HUMAN
θ value	2.98157e-11 (rank : 125)	NC score	0.637958 (rank : 109)
Query Neighborhood Hits	583	Target Neighborhood Hits	401	Shared Neighborhood Hits	258
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

MYPC3_HUMAN
θ value	2.98157e-11 (rank : 126)	NC score	0.678823 (rank : 90)
Query Neighborhood Hits	583	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NEGR1_HUMAN
θ value	3.89403e-11 (rank : 127)	NC score	0.750843 (rank : 68)
Query Neighborhood Hits	583	Target Neighborhood Hits	346	Shared Neighborhood Hits	302
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

TENN_MOUSE
θ value	5.08577e-11 (rank : 128)	NC score	0.352613 (rank : 231)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	155
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENR_MOUSE
θ value	6.64225e-11 (rank : 129)	NC score	0.337548 (rank : 243)
Query Neighborhood Hits	583	Target Neighborhood Hits	531	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

CEAM5_HUMAN
θ value	8.67504e-11 (rank : 130)	NC score	0.637182 (rank : 110)
Query Neighborhood Hits	583	Target Neighborhood Hits	343	Shared Neighborhood Hits	279
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

NEGR1_MOUSE
θ value	8.67504e-11 (rank : 131)	NC score	0.748129 (rank : 70)
Query Neighborhood Hits	583	Target Neighborhood Hits	349	Shared Neighborhood Hits	301
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NTRI_HUMAN
θ value	8.67504e-11 (rank : 132)	NC score	0.741041 (rank : 74)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	304
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

TENN_HUMAN
θ value	8.67504e-11 (rank : 133)	NC score	0.316538 (rank : 265)
Query Neighborhood Hits	583	Target Neighborhood Hits	453	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TIE2_MOUSE
θ value	8.67504e-11 (rank : 134)	NC score	0.254739 (rank : 323)
Query Neighborhood Hits	583	Target Neighborhood Hits	1204	Shared Neighborhood Hits	202
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

COEA1_MOUSE
θ value	1.133e-10 (rank : 135)	NC score	0.372236 (rank : 209)
Query Neighborhood Hits	583	Target Neighborhood Hits	402	Shared Neighborhood Hits	121
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

NPHN_MOUSE
θ value	1.133e-10 (rank : 136)	NC score	0.745553 (rank : 71)
Query Neighborhood Hits	583	Target Neighborhood Hits	370	Shared Neighborhood Hits	301
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MERTK_HUMAN
θ value	1.47974e-10 (rank : 137)	NC score	0.323785 (rank : 253)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	276
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PTPRB_HUMAN
θ value	1.47974e-10 (rank : 138)	NC score	0.262822 (rank : 312)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	111
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

SORL_HUMAN
θ value	1.47974e-10 (rank : 139)	NC score	0.260286 (rank : 316)
Query Neighborhood Hits	583	Target Neighborhood Hits	440	Shared Neighborhood Hits	133
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

MAG_HUMAN
θ value	2.52405e-10 (rank : 140)	NC score	0.688863 (rank : 86)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	254
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

CEAM1_MOUSE
θ value	3.29651e-10 (rank : 141)	NC score	0.625956 (rank : 116)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	272
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

FGFR4_MOUSE
θ value	4.30538e-10 (rank : 142)	NC score	0.368417 (rank : 211)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	305
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

NTRI_MOUSE
θ value	5.62301e-10 (rank : 143)	NC score	0.743835 (rank : 72)
Query Neighborhood Hits	583	Target Neighborhood Hits	342	Shared Neighborhood Hits	303
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

FGFR4_HUMAN
θ value	1.25267e-09 (rank : 144)	NC score	0.361556 (rank : 220)
Query Neighborhood Hits	583	Target Neighborhood Hits	1037	Shared Neighborhood Hits	303
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

CI094_HUMAN
θ value	1.63604e-09 (rank : 145)	NC score	0.571122 (rank : 139)
Query Neighborhood Hits	583	Target Neighborhood Hits	310	Shared Neighborhood Hits	231
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

FGFR2_HUMAN
θ value	2.13673e-09 (rank : 146)	NC score	0.343184 (rank : 237)
Query Neighborhood Hits	583	Target Neighborhood Hits	1062	Shared Neighborhood Hits	295
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

ICAM5_MOUSE
θ value	2.13673e-09 (rank : 147)	NC score	0.650132 (rank : 104)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	250
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

INSRR_HUMAN
θ value	2.13673e-09 (rank : 148)	NC score	0.207015 (rank : 372)
Query Neighborhood Hits	583	Target Neighborhood Hits	950	Shared Neighborhood Hits	146
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ITB4_HUMAN
θ value	2.13673e-09 (rank : 149)	NC score	0.395549 (rank : 198)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	163
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

MUC18_HUMAN
θ value	2.79066e-09 (rank : 150)	NC score	0.665666 (rank : 97)
Query Neighborhood Hits	583	Target Neighborhood Hits	275	Shared Neighborhood Hits	229
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

FSTL4_MOUSE
θ value	3.64472e-09 (rank : 151)	NC score	0.671810 (rank : 95)
Query Neighborhood Hits	583	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL4_HUMAN
θ value	4.76016e-09 (rank : 152)	NC score	0.678235 (rank : 92)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	268
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

KAZD1_MOUSE
θ value	8.11959e-09 (rank : 153)	NC score	0.592969 (rank : 132)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

KIRR3_MOUSE
θ value	8.11959e-09 (rank : 154)	NC score	0.636038 (rank : 111)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

ROR2_HUMAN
θ value	8.11959e-09 (rank : 155)	NC score	0.299855 (rank : 279)
Query Neighborhood Hits	583	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHA7_HUMAN
θ value	1.06045e-08 (rank : 156)	NC score	0.246201 (rank : 333)
Query Neighborhood Hits	583	Target Neighborhood Hits	1053	Shared Neighborhood Hits	195
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FGFR1_HUMAN
θ value	1.06045e-08 (rank : 157)	NC score	0.354065 (rank : 226)
Query Neighborhood Hits	583	Target Neighborhood Hits	1069	Shared Neighborhood Hits	305
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.06045e-08 (rank : 158)	NC score	0.353524 (rank : 229)
Query Neighborhood Hits	583	Target Neighborhood Hits	1068	Shared Neighborhood Hits	304
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

ICAM5_HUMAN
θ value	1.06045e-08 (rank : 159)	NC score	0.632375 (rank : 114)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	238
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KIRR3_HUMAN
θ value	1.06045e-08 (rank : 160)	NC score	0.642095 (rank : 107)
Query Neighborhood Hits	583	Target Neighborhood Hits	302	Shared Neighborhood Hits	246
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

LRFN4_MOUSE
θ value	1.06045e-08 (rank : 161)	NC score	0.397459 (rank : 195)
Query Neighborhood Hits	583	Target Neighborhood Hits	442	Shared Neighborhood Hits	213
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

UFO_MOUSE
θ value	1.06045e-08 (rank : 162)	NC score	0.310333 (rank : 271)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	260
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

TENX_HUMAN
θ value	1.38499e-08 (rank : 163)	NC score	0.267365 (rank : 306)
Query Neighborhood Hits	583	Target Neighborhood Hits	789	Shared Neighborhood Hits	168
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

COKA1_HUMAN
θ value	1.80886e-08 (rank : 164)	NC score	0.310079 (rank : 272)
Query Neighborhood Hits	583	Target Neighborhood Hits	403	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

EPHA5_HUMAN
θ value	1.80886e-08 (rank : 165)	NC score	0.230741 (rank : 355)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	196
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PTPRK_HUMAN
θ value	1.80886e-08 (rank : 166)	NC score	0.317599 (rank : 263)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	144
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	1.80886e-08 (rank : 167)	NC score	0.321008 (rank : 260)
Query Neighborhood Hits	583	Target Neighborhood Hits	223	Shared Neighborhood Hits	143
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

ATL3_HUMAN
θ value	2.36244e-08 (rank : 168)	NC score	0.450059 (rank : 169)
Query Neighborhood Hits	583	Target Neighborhood Hits	414	Shared Neighborhood Hits	264
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ROR2_MOUSE
θ value	2.36244e-08 (rank : 169)	NC score	0.309760 (rank : 274)
Query Neighborhood Hits	583	Target Neighborhood Hits	1000	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

VGFR2_MOUSE
θ value	2.36244e-08 (rank : 170)	NC score	0.397554 (rank : 194)
Query Neighborhood Hits	583	Target Neighborhood Hits	1089	Shared Neighborhood Hits	329
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA7_MOUSE
θ value	3.08544e-08 (rank : 171)	NC score	0.244100 (rank : 334)
Query Neighborhood Hits	583	Target Neighborhood Hits	1025	Shared Neighborhood Hits	194
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

TENA_HUMAN
θ value	3.08544e-08 (rank : 172)	NC score	0.267864 (rank : 305)
Query Neighborhood Hits	583	Target Neighborhood Hits	631	Shared Neighborhood Hits	161
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

CEA20_HUMAN
θ value	4.0297e-08 (rank : 173)	NC score	0.598244 (rank : 129)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	203
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

LRFN4_HUMAN
θ value	4.0297e-08 (rank : 174)	NC score	0.401807 (rank : 189)
Query Neighborhood Hits	583	Target Neighborhood Hits	462	Shared Neighborhood Hits	220
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

PSG3_HUMAN
θ value	4.0297e-08 (rank : 175)	NC score	0.450834 (rank : 168)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	214
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

SORL_MOUSE
θ value	4.0297e-08 (rank : 176)	NC score	0.252678 (rank : 327)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	132
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

EPHB4_MOUSE
θ value	5.26297e-08 (rank : 177)	NC score	0.234913 (rank : 349)
Query Neighborhood Hits	583	Target Neighborhood Hits	1013	Shared Neighborhood Hits	187
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

NTRK3_HUMAN
θ value	5.26297e-08 (rank : 178)	NC score	0.296858 (rank : 280)
Query Neighborhood Hits	583	Target Neighborhood Hits	1115	Shared Neighborhood Hits	256
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

SN_HUMAN
θ value	6.87365e-08 (rank : 179)	NC score	0.656858 (rank : 100)
Query Neighborhood Hits	583	Target Neighborhood Hits	434	Shared Neighborhood Hits	292
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

FGFR2_MOUSE
θ value	8.97725e-08 (rank : 180)	NC score	0.332586 (rank : 248)
Query Neighborhood Hits	583	Target Neighborhood Hits	1062	Shared Neighborhood Hits	295
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PSG2_HUMAN
θ value	8.97725e-08 (rank : 181)	NC score	0.425721 (rank : 178)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	207
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

TMIGD_MOUSE
θ value	8.97725e-08 (rank : 182)	NC score	0.650839 (rank : 103)
Query Neighborhood Hits	583	Target Neighborhood Hits	234	Shared Neighborhood Hits	224
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

VGFR3_MOUSE
θ value	8.97725e-08 (rank : 183)	NC score	0.344450 (rank : 236)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	312
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

INSRR_MOUSE
θ value	1.17247e-07 (rank : 184)	NC score	0.205737 (rank : 373)
Query Neighborhood Hits	583	Target Neighborhood Hits	961	Shared Neighborhood Hits	146
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PSG4_HUMAN
θ value	1.17247e-07 (rank : 185)	NC score	0.447510 (rank : 170)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	211
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

KAZD1_HUMAN
θ value	1.53129e-07 (rank : 186)	NC score	0.547330 (rank : 147)
Query Neighborhood Hits	583	Target Neighborhood Hits	248	Shared Neighborhood Hits	170
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NTRK2_HUMAN
θ value	1.53129e-07 (rank : 187)	NC score	0.293182 (rank : 282)
Query Neighborhood Hits	583	Target Neighborhood Hits	1081	Shared Neighborhood Hits	264
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

VCAM1_MOUSE
θ value	1.53129e-07 (rank : 188)	NC score	0.704792 (rank : 77)
Query Neighborhood Hits	583	Target Neighborhood Hits	320	Shared Neighborhood Hits	267
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

VGFR3_HUMAN
θ value	1.53129e-07 (rank : 189)	NC score	0.345883 (rank : 235)
Query Neighborhood Hits	583	Target Neighborhood Hits	1037	Shared Neighborhood Hits	299
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

IGS4B_HUMAN
θ value	1.99992e-07 (rank : 190)	NC score	0.594397 (rank : 130)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

VCAM1_HUMAN
θ value	2.61198e-07 (rank : 191)	NC score	0.697518 (rank : 81)
Query Neighborhood Hits	583	Target Neighborhood Hits	352	Shared Neighborhood Hits	271
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

VGFR2_HUMAN
θ value	2.61198e-07 (rank : 192)	NC score	0.401325 (rank : 191)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	337
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

COEA1_HUMAN
θ value	3.41135e-07 (rank : 193)	NC score	0.323462 (rank : 255)
Query Neighborhood Hits	583	Target Neighborhood Hits	427	Shared Neighborhood Hits	132
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

ROS_HUMAN
θ value	3.41135e-07 (rank : 194)	NC score	0.243724 (rank : 335)
Query Neighborhood Hits	583	Target Neighborhood Hits	907	Shared Neighborhood Hits	193
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

IGS4B_MOUSE
θ value	4.45536e-07 (rank : 195)	NC score	0.604760 (rank : 123)
Query Neighborhood Hits	583	Target Neighborhood Hits	328	Shared Neighborhood Hits	262
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

NTRK2_MOUSE
θ value	4.45536e-07 (rank : 196)	NC score	0.292440 (rank : 283)
Query Neighborhood Hits	583	Target Neighborhood Hits	1088	Shared Neighborhood Hits	262
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

CEAM1_HUMAN
θ value	5.81887e-07 (rank : 197)	NC score	0.573469 (rank : 137)
Query Neighborhood Hits	583	Target Neighborhood Hits	348	Shared Neighborhood Hits	262
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

PSG7_HUMAN
θ value	5.81887e-07 (rank : 198)	NC score	0.434528 (rank : 174)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	211
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PSG8_HUMAN
θ value	5.81887e-07 (rank : 199)	NC score	0.443975 (rank : 171)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	213
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

ROR1_HUMAN
θ value	5.81887e-07 (rank : 200)	NC score	0.285564 (rank : 287)
Query Neighborhood Hits	583	Target Neighborhood Hits	1018	Shared Neighborhood Hits	259
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

CEAM8_HUMAN
θ value	7.59969e-07 (rank : 201)	NC score	0.462286 (rank : 166)
Query Neighborhood Hits	583	Target Neighborhood Hits	264	Shared Neighborhood Hits	229
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

IL6RB_HUMAN
θ value	7.59969e-07 (rank : 202)	NC score	0.438954 (rank : 172)
Query Neighborhood Hits	583	Target Neighborhood Hits	181	Shared Neighborhood Hits	131
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

TRIO_HUMAN
θ value	7.59969e-07 (rank : 203)	NC score	0.193224 (rank : 387)
Query Neighborhood Hits	583	Target Neighborhood Hits	1580	Shared Neighborhood Hits	290
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PSG6_HUMAN
θ value	9.92553e-07 (rank : 204)	NC score	0.422423 (rank : 181)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	201
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

CD276_HUMAN
θ value	1.29631e-06 (rank : 205)	NC score	0.384022 (rank : 205)
Query Neighborhood Hits	583	Target Neighborhood Hits	261	Shared Neighborhood Hits	177
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

EPHB4_HUMAN
θ value	1.29631e-06 (rank : 206)	NC score	0.228584 (rank : 356)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	193
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PSG1_HUMAN
θ value	1.29631e-06 (rank : 207)	NC score	0.428257 (rank : 177)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	207
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

TIE1_HUMAN
θ value	1.29631e-06 (rank : 208)	NC score	0.259665 (rank : 317)
Query Neighborhood Hits	583	Target Neighborhood Hits	1241	Shared Neighborhood Hits	223
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

LAG3_HUMAN
θ value	1.69304e-06 (rank : 209)	NC score	0.225738 (rank : 358)
Query Neighborhood Hits	583	Target Neighborhood Hits	129	Shared Neighborhood Hits	85
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

MYBPH_HUMAN
θ value	1.69304e-06 (rank : 210)	NC score	0.592013 (rank : 133)
Query Neighborhood Hits	583	Target Neighborhood Hits	256	Shared Neighborhood Hits	232
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

IL1R2_HUMAN
θ value	2.21117e-06 (rank : 211)	NC score	0.408902 (rank : 187)
Query Neighborhood Hits	583	Target Neighborhood Hits	153	Shared Neighborhood Hits	140
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

PSG10_HUMAN
θ value	2.88788e-06 (rank : 212)	NC score	0.417471 (rank : 184)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	197
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PTPRU_HUMAN
θ value	2.88788e-06 (rank : 213)	NC score	0.331896 (rank : 249)
Query Neighborhood Hits	583	Target Neighborhood Hits	237	Shared Neighborhood Hits	160
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

ROR1_MOUSE
θ value	2.88788e-06 (rank : 214)	NC score	0.283146 (rank : 289)
Query Neighborhood Hits	583	Target Neighborhood Hits	1025	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

SN_MOUSE
θ value	2.88788e-06 (rank : 215)	NC score	0.659204 (rank : 99)
Query Neighborhood Hits	583	Target Neighborhood Hits	416	Shared Neighborhood Hits	298
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

EPHA3_MOUSE
θ value	3.77169e-06 (rank : 216)	NC score	0.239719 (rank : 343)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	198
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

LRFN2_MOUSE
θ value	4.92598e-06 (rank : 217)	NC score	0.388735 (rank : 202)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	224
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PGFRA_MOUSE
θ value	4.92598e-06 (rank : 218)	NC score	0.283039 (rank : 290)
Query Neighborhood Hits	583	Target Neighborhood Hits	975	Shared Neighborhood Hits	244
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PSG5_HUMAN
θ value	4.92598e-06 (rank : 219)	NC score	0.401435 (rank : 190)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	204
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

LRFN2_HUMAN
θ value	6.43352e-06 (rank : 220)	NC score	0.389069 (rank : 201)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	219
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PSG9_HUMAN
θ value	6.43352e-06 (rank : 221)	NC score	0.403898 (rank : 188)
Query Neighborhood Hits	583	Target Neighborhood Hits	221	Shared Neighborhood Hits	198
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

VSIG2_HUMAN
θ value	6.43352e-06 (rank : 222)	NC score	0.578750 (rank : 135)
Query Neighborhood Hits	583	Target Neighborhood Hits	321	Shared Neighborhood Hits	250
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CD22_HUMAN
θ value	8.40245e-06 (rank : 223)	NC score	0.646854 (rank : 105)
Query Neighborhood Hits	583	Target Neighborhood Hits	365	Shared Neighborhood Hits	265
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

EPHA3_HUMAN
θ value	1.09739e-05 (rank : 224)	NC score	0.235217 (rank : 348)
Query Neighborhood Hits	583	Target Neighborhood Hits	1005	Shared Neighborhood Hits	196
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

PGFRA_HUMAN
θ value	1.09739e-05 (rank : 225)	NC score	0.284850 (rank : 288)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	243
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TENA_MOUSE
θ value	1.09739e-05 (rank : 226)	NC score	0.250020 (rank : 331)
Query Neighborhood Hits	583	Target Neighborhood Hits	596	Shared Neighborhood Hits	146
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

EPHA2_HUMAN
θ value	1.43324e-05 (rank : 227)	NC score	0.217800 (rank : 365)
Query Neighborhood Hits	583	Target Neighborhood Hits	1021	Shared Neighborhood Hits	180
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

IL6RB_MOUSE
θ value	1.43324e-05 (rank : 228)	NC score	0.398553 (rank : 193)
Query Neighborhood Hits	583	Target Neighborhood Hits	168	Shared Neighborhood Hits	129
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

JAM3_HUMAN
θ value	1.43324e-05 (rank : 229)	NC score	0.634180 (rank : 113)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	245
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

LRFN3_HUMAN
θ value	1.43324e-05 (rank : 230)	NC score	0.367560 (rank : 212)
Query Neighborhood Hits	583	Target Neighborhood Hits	444	Shared Neighborhood Hits	208
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

RAGE_MOUSE
θ value	1.43324e-05 (rank : 231)	NC score	0.644228 (rank : 106)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	225
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

TARSH_HUMAN
θ value	1.43324e-05 (rank : 232)	NC score	0.273833 (rank : 295)
Query Neighborhood Hits	583	Target Neighborhood Hits	768	Shared Neighborhood Hits	167
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

LRRN5_HUMAN
θ value	1.87187e-05 (rank : 233)	NC score	0.312705 (rank : 269)
Query Neighborhood Hits	583	Target Neighborhood Hits	493	Shared Neighborhood Hits	238
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

MYBPH_MOUSE
θ value	1.87187e-05 (rank : 234)	NC score	0.601401 (rank : 127)
Query Neighborhood Hits	583	Target Neighborhood Hits	290	Shared Neighborhood Hits	242
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

PSG11_HUMAN
θ value	1.87187e-05 (rank : 235)	NC score	0.429999 (rank : 176)
Query Neighborhood Hits	583	Target Neighborhood Hits	223	Shared Neighborhood Hits	203
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

CILP2_HUMAN
θ value	3.19293e-05 (rank : 236)	NC score	0.389957 (rank : 200)
Query Neighborhood Hits	583	Target Neighborhood Hits	307	Shared Neighborhood Hits	192
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LU_HUMAN
θ value	3.19293e-05 (rank : 237)	NC score	0.688319 (rank : 87)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	253
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

PGFRB_MOUSE
θ value	3.19293e-05 (rank : 238)	NC score	0.276580 (rank : 294)
Query Neighborhood Hits	583	Target Neighborhood Hits	960	Shared Neighborhood Hits	228
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHB1_HUMAN
θ value	4.1701e-05 (rank : 239)	NC score	0.221915 (rank : 364)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	181
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

INSR_MOUSE
θ value	4.1701e-05 (rank : 240)	NC score	0.197625 (rank : 382)
Query Neighborhood Hits	583	Target Neighborhood Hits	968	Shared Neighborhood Hits	147
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

EPHB3_HUMAN
θ value	5.44631e-05 (rank : 241)	NC score	0.240298 (rank : 340)
Query Neighborhood Hits	583	Target Neighborhood Hits	996	Shared Neighborhood Hits	190
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA4_MOUSE
θ value	7.1131e-05 (rank : 242)	NC score	0.236826 (rank : 347)
Query Neighborhood Hits	583	Target Neighborhood Hits	982	Shared Neighborhood Hits	188
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

IRPL2_HUMAN
θ value	7.1131e-05 (rank : 243)	NC score	0.341911 (rank : 239)
Query Neighborhood Hits	583	Target Neighborhood Hits	194	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

PCLO_MOUSE
θ value	7.1131e-05 (rank : 244)	NC score	0.042124 (rank : 1183)
Query Neighborhood Hits	583	Target Neighborhood Hits	2275	Shared Neighborhood Hits	115
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

EPHB2_HUMAN
θ value	9.29e-05 (rank : 245)	NC score	0.222023 (rank : 363)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	177
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	9.29e-05 (rank : 246)	NC score	0.222038 (rank : 362)
Query Neighborhood Hits	583	Target Neighborhood Hits	982	Shared Neighborhood Hits	177
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

GPA33_MOUSE
θ value	9.29e-05 (rank : 247)	NC score	0.496188 (rank : 158)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	214
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

ILRL1_HUMAN
θ value	9.29e-05 (rank : 248)	NC score	0.260810 (rank : 315)
Query Neighborhood Hits	583	Target Neighborhood Hits	167	Shared Neighborhood Hits	133
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

RAGE_HUMAN
θ value	9.29e-05 (rank : 249)	NC score	0.677074 (rank : 93)
Query Neighborhood Hits	583	Target Neighborhood Hits	269	Shared Neighborhood Hits	243
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CSF3R_HUMAN
θ value	0.000121331 (rank : 250)	NC score	0.323551 (rank : 254)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	104
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

EPHA2_MOUSE
θ value	0.000121331 (rank : 251)	NC score	0.211821 (rank : 368)
Query Neighborhood Hits	583	Target Neighborhood Hits	1020	Shared Neighborhood Hits	175
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA4_HUMAN
θ value	0.000121331 (rank : 252)	NC score	0.233840 (rank : 351)
Query Neighborhood Hits	583	Target Neighborhood Hits	975	Shared Neighborhood Hits	185
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

IRPL2_MOUSE
θ value	0.000121331 (rank : 253)	NC score	0.338098 (rank : 241)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	149
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

LAG3_MOUSE
θ value	0.000121331 (rank : 254)	NC score	0.240153 (rank : 341)
Query Neighborhood Hits	583	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

LRRN3_HUMAN
θ value	0.000121331 (rank : 255)	NC score	0.335673 (rank : 244)
Query Neighborhood Hits	583	Target Neighborhood Hits	461	Shared Neighborhood Hits	225
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

TMIGD_HUMAN
θ value	0.000121331 (rank : 256)	NC score	0.668894 (rank : 96)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	222
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

EPHB3_MOUSE
θ value	0.000158464 (rank : 257)	NC score	0.242215 (rank : 336)
Query Neighborhood Hits	583	Target Neighborhood Hits	996	Shared Neighborhood Hits	191
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

LRFN5_MOUSE
θ value	0.000158464 (rank : 258)	NC score	0.364123 (rank : 216)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	228
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

NPTN_HUMAN
θ value	0.000158464 (rank : 259)	NC score	0.618768 (rank : 117)
Query Neighborhood Hits	583	Target Neighborhood Hits	212	Shared Neighborhood Hits	201
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

JAM3_MOUSE
θ value	0.00020696 (rank : 260)	NC score	0.631724 (rank : 115)
Query Neighborhood Hits	583	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

NTRK1_HUMAN
θ value	0.00020696 (rank : 261)	NC score	0.208578 (rank : 369)
Query Neighborhood Hits	583	Target Neighborhood Hits	1023	Shared Neighborhood Hits	196
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SIG11_HUMAN
θ value	0.00020696 (rank : 262)	NC score	0.563638 (rank : 142)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	246
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

CEAM6_HUMAN
θ value	0.000270298 (rank : 263)	NC score	0.512689 (rank : 152)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	260
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

EPHAA_HUMAN
θ value	0.000270298 (rank : 264)	NC score	0.207598 (rank : 370)
Query Neighborhood Hits	583	Target Neighborhood Hits	960	Shared Neighborhood Hits	160
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

GPA33_HUMAN
θ value	0.000270298 (rank : 265)	NC score	0.464749 (rank : 165)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

JAM2_HUMAN
θ value	0.000270298 (rank : 266)	NC score	0.606306 (rank : 121)
Query Neighborhood Hits	583	Target Neighborhood Hits	304	Shared Neighborhood Hits	276
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LRFN5_HUMAN
θ value	0.000270298 (rank : 267)	NC score	0.357056 (rank : 222)
Query Neighborhood Hits	583	Target Neighborhood Hits	464	Shared Neighborhood Hits	224
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PTPRV_MOUSE
θ value	0.000270298 (rank : 268)	NC score	0.226843 (rank : 357)
Query Neighborhood Hits	583	Target Neighborhood Hits	179	Shared Neighborhood Hits	83
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

TIE1_MOUSE
θ value	0.000270298 (rank : 269)	NC score	0.267998 (rank : 304)
Query Neighborhood Hits	583	Target Neighborhood Hits	1266	Shared Neighborhood Hits	237
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	0.000461057 (rank : 270)	NC score	0.256504 (rank : 320)
Query Neighborhood Hits	583	Target Neighborhood Hits	912	Shared Neighborhood Hits	193
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

LRC4B_HUMAN
θ value	0.000461057 (rank : 271)	NC score	0.261045 (rank : 314)
Query Neighborhood Hits	583	Target Neighborhood Hits	479	Shared Neighborhood Hits	216
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	0.000461057 (rank : 272)	NC score	0.264037 (rank : 309)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	218
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRFN3_MOUSE
θ value	0.000461057 (rank : 273)	NC score	0.384862 (rank : 204)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

PTPRJ_HUMAN
θ value	0.000461057 (rank : 274)	NC score	0.224597 (rank : 359)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

CSF1R_MOUSE
θ value	0.000786445 (rank : 275)	NC score	0.309986 (rank : 273)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	254
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FCRL5_HUMAN
θ value	0.000786445 (rank : 276)	NC score	0.564135 (rank : 141)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	223
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

JAM1_MOUSE
θ value	0.000786445 (rank : 277)	NC score	0.613283 (rank : 120)
Query Neighborhood Hits	583	Target Neighborhood Hits	287	Shared Neighborhood Hits	245
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

CD166_MOUSE
θ value	0.00102713 (rank : 278)	NC score	0.502506 (rank : 154)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	203
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

INSR_HUMAN
θ value	0.00102713 (rank : 279)	NC score	0.192147 (rank : 388)
Query Neighborhood Hits	583	Target Neighborhood Hits	963	Shared Neighborhood Hits	143
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

JAM2_MOUSE
θ value	0.00102713 (rank : 280)	NC score	0.587183 (rank : 134)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

LIFR_HUMAN
θ value	0.00102713 (rank : 281)	NC score	0.383784 (rank : 206)
Query Neighborhood Hits	583	Target Neighborhood Hits	130	Shared Neighborhood Hits	96
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

NPTN_MOUSE
θ value	0.00102713 (rank : 282)	NC score	0.605541 (rank : 122)
Query Neighborhood Hits	583	Target Neighborhood Hits	216	Shared Neighborhood Hits	201
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

SIG10_HUMAN
θ value	0.00102713 (rank : 283)	NC score	0.553872 (rank : 146)
Query Neighborhood Hits	583	Target Neighborhood Hits	363	Shared Neighborhood Hits	244
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

EPHB6_MOUSE
θ value	0.00134147 (rank : 284)	NC score	0.249492 (rank : 332)
Query Neighborhood Hits	583	Target Neighborhood Hits	906	Shared Neighborhood Hits	182
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

IRPL1_MOUSE
θ value	0.00134147 (rank : 285)	NC score	0.340697 (rank : 240)
Query Neighborhood Hits	583	Target Neighborhood Hits	186	Shared Neighborhood Hits	161
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

JAM1_HUMAN
θ value	0.00134147 (rank : 286)	NC score	0.640132 (rank : 108)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

OX2G_MOUSE
θ value	0.00134147 (rank : 287)	NC score	0.241775 (rank : 337)
Query Neighborhood Hits	583	Target Neighborhood Hits	105	Shared Neighborhood Hits	89
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

PTPRJ_MOUSE
θ value	0.00134147 (rank : 288)	NC score	0.223861 (rank : 360)
Query Neighborhood Hits	583	Target Neighborhood Hits	188	Shared Neighborhood Hits	97
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

I11RA_HUMAN
θ value	0.00175202 (rank : 289)	NC score	0.140131 (rank : 433)
Query Neighborhood Hits	583	Target Neighborhood Hits	138	Shared Neighborhood Hits	70
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I12R2_MOUSE
θ value	0.00175202 (rank : 290)	NC score	0.361615 (rank : 218)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	116
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LRRN1_HUMAN
θ value	0.00175202 (rank : 291)	NC score	0.332803 (rank : 247)
Query Neighborhood Hits	583	Target Neighborhood Hits	518	Shared Neighborhood Hits	260
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

ANKF1_HUMAN
θ value	0.00228821 (rank : 292)	NC score	0.190772 (rank : 389)
Query Neighborhood Hits	583	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

CD45_HUMAN
θ value	0.00228821 (rank : 293)	NC score	0.168375 (rank : 403)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	78
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

IRPL1_HUMAN
θ value	0.00228821 (rank : 294)	NC score	0.330755 (rank : 250)
Query Neighborhood Hits	583	Target Neighborhood Hits	196	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

LIFR_MOUSE
θ value	0.00228821 (rank : 295)	NC score	0.373846 (rank : 208)
Query Neighborhood Hits	583	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

NGL1_HUMAN
θ value	0.00228821 (rank : 296)	NC score	0.264994 (rank : 308)
Query Neighborhood Hits	583	Target Neighborhood Hits	511	Shared Neighborhood Hits	230
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PVRL1_HUMAN
θ value	0.00228821 (rank : 297)	NC score	0.322230 (rank : 256)
Query Neighborhood Hits	583	Target Neighborhood Hits	219	Shared Neighborhood Hits	168
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

VSIG2_MOUSE
θ value	0.00228821 (rank : 298)	NC score	0.556298 (rank : 144)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	235
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

EPHA5_MOUSE
θ value	0.00298849 (rank : 299)	NC score	0.207450 (rank : 371)
Query Neighborhood Hits	583	Target Neighborhood Hits	950	Shared Neighborhood Hits	184
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

MALT1_HUMAN
θ value	0.00298849 (rank : 300)	NC score	0.662606 (rank : 98)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

NGL1_MOUSE
θ value	0.00298849 (rank : 301)	NC score	0.265235 (rank : 307)
Query Neighborhood Hits	583	Target Neighborhood Hits	512	Shared Neighborhood Hits	230
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

PTPRO_HUMAN
θ value	0.00298849 (rank : 302)	NC score	0.193386 (rank : 386)
Query Neighborhood Hits	583	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

LRRC4_HUMAN
θ value	0.00390308 (rank : 303)	NC score	0.234137 (rank : 350)
Query Neighborhood Hits	583	Target Neighborhood Hits	444	Shared Neighborhood Hits	198
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

BASI_MOUSE
θ value	0.00509761 (rank : 304)	NC score	0.542471 (rank : 149)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	205
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

CEAM7_HUMAN
θ value	0.00509761 (rank : 305)	NC score	0.315915 (rank : 266)
Query Neighborhood Hits	583	Target Neighborhood Hits	170	Shared Neighborhood Hits	140
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

EMB_MOUSE
θ value	0.00509761 (rank : 306)	NC score	0.280855 (rank : 292)
Query Neighborhood Hits	583	Target Neighborhood Hits	83	Shared Neighborhood Hits	80
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

LRRN1_MOUSE
θ value	0.00509761 (rank : 307)	NC score	0.321941 (rank : 257)
Query Neighborhood Hits	583	Target Neighborhood Hits	508	Shared Neighborhood Hits	256
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

RIMB2_HUMAN
θ value	0.00509761 (rank : 308)	NC score	0.176691 (rank : 400)
Query Neighborhood Hits	583	Target Neighborhood Hits	263	Shared Neighborhood Hits	63
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SIGL5_MOUSE
θ value	0.00509761 (rank : 309)	NC score	0.451965 (rank : 167)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	238
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

EPHA8_HUMAN
θ value	0.00665767 (rank : 310)	NC score	0.237840 (rank : 344)
Query Neighborhood Hits	583	Target Neighborhood Hits	956	Shared Neighborhood Hits	192
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	0.00665767 (rank : 311)	NC score	0.240821 (rank : 338)
Query Neighborhood Hits	583	Target Neighborhood Hits	969	Shared Neighborhood Hits	195
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

SEM4D_HUMAN
θ value	0.00665767 (rank : 312)	NC score	0.053955 (rank : 1066)
Query Neighborhood Hits	583	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

UNC5C_HUMAN
θ value	0.00665767 (rank : 313)	NC score	0.269399 (rank : 301)
Query Neighborhood Hits	583	Target Neighborhood Hits	226	Shared Neighborhood Hits	125
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

BT2A3_HUMAN
θ value	0.00869519 (rank : 314)	NC score	0.045705 (rank : 1179)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

CD248_HUMAN
θ value	0.00869519 (rank : 315)	NC score	0.038362 (rank : 1190)
Query Neighborhood Hits	583	Target Neighborhood Hits	679	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MOX2R_MOUSE
θ value	0.0113563 (rank : 316)	NC score	0.317513 (rank : 264)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

OX2G_HUMAN
θ value	0.0113563 (rank : 317)	NC score	0.217466 (rank : 366)
Query Neighborhood Hits	583	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

PVRL3_HUMAN
θ value	0.0113563 (rank : 318)	NC score	0.317617 (rank : 262)
Query Neighborhood Hits	583	Target Neighborhood Hits	204	Shared Neighborhood Hits	164
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

CD166_HUMAN
θ value	0.0148317 (rank : 319)	NC score	0.474954 (rank : 161)
Query Neighborhood Hits	583	Target Neighborhood Hits	247	Shared Neighborhood Hits	194
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

LRRN3_MOUSE
θ value	0.0148317 (rank : 320)	NC score	0.315327 (rank : 268)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PVRL3_MOUSE
θ value	0.0148317 (rank : 321)	NC score	0.334747 (rank : 245)
Query Neighborhood Hits	583	Target Neighborhood Hits	212	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

SIG12_HUMAN
θ value	0.0148317 (rank : 322)	NC score	0.342181 (rank : 238)
Query Neighborhood Hits	583	Target Neighborhood Hits	245	Shared Neighborhood Hits	222
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

AMGO3_HUMAN
θ value	0.0193708 (rank : 323)	NC score	0.121496 (rank : 490)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

EPHA6_HUMAN
θ value	0.0193708 (rank : 324)	NC score	0.214408 (rank : 367)
Query Neighborhood Hits	583	Target Neighborhood Hits	959	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IBP7_MOUSE
θ value	0.0193708 (rank : 325)	NC score	0.483793 (rank : 160)
Query Neighborhood Hits	583	Target Neighborhood Hits	230	Shared Neighborhood Hits	163
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IL1R1_HUMAN
θ value	0.0193708 (rank : 326)	NC score	0.289662 (rank : 286)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	123
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IL1R2_MOUSE
θ value	0.0193708 (rank : 327)	NC score	0.330024 (rank : 252)
Query Neighborhood Hits	583	Target Neighborhood Hits	125	Shared Neighborhood Hits	108
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

MFA3L_MOUSE
θ value	0.0193708 (rank : 328)	NC score	0.467520 (rank : 163)
Query Neighborhood Hits	583	Target Neighborhood Hits	214	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

PGFRB_HUMAN
θ value	0.0193708 (rank : 329)	NC score	0.263940 (rank : 310)
Query Neighborhood Hits	583	Target Neighborhood Hits	962	Shared Neighborhood Hits	234
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

UNC5C_MOUSE
θ value	0.0193708 (rank : 330)	NC score	0.270120 (rank : 300)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	129
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5D_HUMAN
θ value	0.0193708 (rank : 331)	NC score	0.330306 (rank : 251)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

DCP1A_HUMAN
θ value	0.0252991 (rank : 332)	NC score	0.036668 (rank : 1192)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

HCFC1_MOUSE
θ value	0.0252991 (rank : 333)	NC score	0.141764 (rank : 431)
Query Neighborhood Hits	583	Target Neighborhood Hits	348	Shared Neighborhood Hits	84
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

UNC5D_MOUSE
θ value	0.0252991 (rank : 334)	NC score	0.337900 (rank : 242)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	179
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

VSIG4_HUMAN
θ value	0.0252991 (rank : 335)	NC score	0.498536 (rank : 157)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

BASI_HUMAN
θ value	0.0330416 (rank : 336)	NC score	0.544597 (rank : 148)
Query Neighborhood Hits	583	Target Neighborhood Hits	211	Shared Neighborhood Hits	196
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

CD22_MOUSE
θ value	0.0330416 (rank : 337)	NC score	0.651359 (rank : 102)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	251
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD4_HUMAN
θ value	0.0330416 (rank : 338)	NC score	0.155617 (rank : 413)
Query Neighborhood Hits	583	Target Neighborhood Hits	122	Shared Neighborhood Hits	66
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

JAML1_MOUSE
θ value	0.0330416 (rank : 339)	NC score	0.240349 (rank : 339)
Query Neighborhood Hits	583	Target Neighborhood Hits	185	Shared Neighborhood Hits	137
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

LRRC4_MOUSE
θ value	0.0330416 (rank : 340)	NC score	0.202523 (rank : 378)
Query Neighborhood Hits	583	Target Neighborhood Hits	412	Shared Neighborhood Hits	168
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

MFA3L_HUMAN
θ value	0.0330416 (rank : 341)	NC score	0.540676 (rank : 150)
Query Neighborhood Hits	583	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

MLL2_HUMAN
θ value	0.0330416 (rank : 342)	NC score	0.021098 (rank : 1241)
Query Neighborhood Hits	583	Target Neighborhood Hits	1788	Shared Neighborhood Hits	83
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RIMB2_MOUSE
θ value	0.0330416 (rank : 343)	NC score	0.164959 (rank : 406)
Query Neighborhood Hits	583	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SIGL8_HUMAN
θ value	0.0330416 (rank : 344)	NC score	0.355508 (rank : 224)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	221
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

BT1A1_MOUSE
θ value	0.0431538 (rank : 345)	NC score	0.111111 (rank : 542)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	131
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

EPHA6_MOUSE
θ value	0.0431538 (rank : 346)	NC score	0.205142 (rank : 374)
Query Neighborhood Hits	583	Target Neighborhood Hits	946	Shared Neighborhood Hits	162
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ESAM_HUMAN
θ value	0.0431538 (rank : 347)	NC score	0.414694 (rank : 185)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

GGA3_HUMAN
θ value	0.0431538 (rank : 348)	NC score	0.021521 (rank : 1237)
Query Neighborhood Hits	583	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

RIMS1_HUMAN
θ value	0.0431538 (rank : 349)	NC score	0.016068 (rank : 1257)
Query Neighborhood Hits	583	Target Neighborhood Hits	437	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

UNC5B_HUMAN
θ value	0.0431538 (rank : 350)	NC score	0.258652 (rank : 318)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	0.0431538 (rank : 351)	NC score	0.253756 (rank : 325)
Query Neighborhood Hits	583	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

CCNK_MOUSE
θ value	0.0563607 (rank : 352)	NC score	0.030600 (rank : 1204)
Query Neighborhood Hits	583	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

ESAM_MOUSE
θ value	0.0563607 (rank : 353)	NC score	0.366518 (rank : 213)
Query Neighborhood Hits	583	Target Neighborhood Hits	222	Shared Neighborhood Hits	179
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

LEPR_MOUSE
θ value	0.0563607 (rank : 354)	NC score	0.120345 (rank : 494)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	60
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

LY9_MOUSE
θ value	0.0563607 (rank : 355)	NC score	0.135123 (rank : 446)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	78
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

PI5PA_MOUSE
θ value	0.0563607 (rank : 356)	NC score	0.031982 (rank : 1199)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	36
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PO121_HUMAN
θ value	0.0563607 (rank : 357)	NC score	0.038712 (rank : 1189)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

AMGO3_MOUSE
θ value	0.0736092 (rank : 358)	NC score	0.113896 (rank : 531)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

CD45_MOUSE
θ value	0.0736092 (rank : 359)	NC score	0.164125 (rank : 407)
Query Neighborhood Hits	583	Target Neighborhood Hits	178	Shared Neighborhood Hits	59
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

HCFC1_HUMAN
θ value	0.0736092 (rank : 360)	NC score	0.118065 (rank : 511)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	72
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

LRC24_HUMAN
θ value	0.0736092 (rank : 361)	NC score	0.281275 (rank : 291)
Query Neighborhood Hits	583	Target Neighborhood Hits	404	Shared Neighborhood Hits	189
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

BCOR_MOUSE
θ value	0.0961366 (rank : 362)	NC score	0.004061 (rank : 1293)
Query Neighborhood Hits	583	Target Neighborhood Hits	521	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

HCFC2_MOUSE
θ value	0.0961366 (rank : 363)	NC score	0.311485 (rank : 270)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IL27B_MOUSE
θ value	0.0961366 (rank : 364)	NC score	0.099314 (rank : 581)
Query Neighborhood Hits	583	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

LEPR_HUMAN
θ value	0.0961366 (rank : 365)	NC score	0.121182 (rank : 492)
Query Neighborhood Hits	583	Target Neighborhood Hits	112	Shared Neighborhood Hits	69
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

PRRT3_HUMAN
θ value	0.0961366 (rank : 366)	NC score	0.050243 (rank : 1175)
Query Neighborhood Hits	583	Target Neighborhood Hits	998	Shared Neighborhood Hits	78
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RERE_HUMAN
θ value	0.0961366 (rank : 367)	NC score	0.025600 (rank : 1223)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RPB1_HUMAN
θ value	0.0961366 (rank : 368)	NC score	0.035364 (rank : 1195)
Query Neighborhood Hits	583	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.0961366 (rank : 369)	NC score	0.035352 (rank : 1196)
Query Neighborhood Hits	583	Target Neighborhood Hits	363	Shared Neighborhood Hits	41
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

TRI42_HUMAN
θ value	0.0961366 (rank : 370)	NC score	0.070820 (rank : 700)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI42_MOUSE
θ value	0.0961366 (rank : 371)	NC score	0.058166 (rank : 919)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

UNC5A_HUMAN
θ value	0.0961366 (rank : 372)	NC score	0.272670 (rank : 297)
Query Neighborhood Hits	583	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ILRL1_MOUSE
θ value	0.125558 (rank : 373)	NC score	0.204471 (rank : 375)
Query Neighborhood Hits	583	Target Neighborhood Hits	172	Shared Neighborhood Hits	133
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

KALM_HUMAN
θ value	0.125558 (rank : 374)	NC score	0.321774 (rank : 258)
Query Neighborhood Hits	583	Target Neighborhood Hits	114	Shared Neighborhood Hits	79
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

MFAP3_HUMAN
θ value	0.125558 (rank : 375)	NC score	0.168367 (rank : 404)
Query Neighborhood Hits	583	Target Neighborhood Hits	91	Shared Neighborhood Hits	84
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MUC2_HUMAN
θ value	0.125558 (rank : 376)	NC score	0.039154 (rank : 1187)
Query Neighborhood Hits	583	Target Neighborhood Hits	906	Shared Neighborhood Hits	81
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ZPBP2_HUMAN
θ value	0.125558 (rank : 377)	NC score	0.038764 (rank : 1188)
Query Neighborhood Hits	583	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X784, Q6X783, Q86XL5	Gene names	ZPBP2, ZPBPL
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor (ZPBP-like protein).

ALEX_HUMAN
θ value	0.163984 (rank : 378)	NC score	0.043662 (rank : 1181)
Query Neighborhood Hits	583	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

I12R2_HUMAN
θ value	0.163984 (rank : 379)	NC score	0.353848 (rank : 227)
Query Neighborhood Hits	583	Target Neighborhood Hits	163	Shared Neighborhood Hits	114
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

MOX2R_HUMAN
θ value	0.163984 (rank : 380)	NC score	0.160669 (rank : 408)
Query Neighborhood Hits	583	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

SEM4D_MOUSE
θ value	0.163984 (rank : 381)	NC score	0.037654 (rank : 1191)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

SIGL5_HUMAN
θ value	0.163984 (rank : 382)	NC score	0.368648 (rank : 210)
Query Neighborhood Hits	583	Target Neighborhood Hits	246	Shared Neighborhood Hits	200
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

CSF1R_HUMAN
θ value	0.21417 (rank : 383)	NC score	0.255770 (rank : 322)
Query Neighborhood Hits	583	Target Neighborhood Hits	943	Shared Neighborhood Hits	215
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHA1_MOUSE
θ value	0.21417 (rank : 384)	NC score	0.187243 (rank : 392)
Query Neighborhood Hits	583	Target Neighborhood Hits	958	Shared Neighborhood Hits	152
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

GGA3_MOUSE
θ value	0.21417 (rank : 385)	NC score	0.023154 (rank : 1231)
Query Neighborhood Hits	583	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

IBP7_HUMAN
θ value	0.21417 (rank : 386)	NC score	0.498651 (rank : 156)
Query Neighborhood Hits	583	Target Neighborhood Hits	220	Shared Neighborhood Hits	166
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IL27B_HUMAN
θ value	0.21417 (rank : 387)	NC score	0.179663 (rank : 396)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

KIT_MOUSE
θ value	0.21417 (rank : 388)	NC score	0.268335 (rank : 302)
Query Neighborhood Hits	583	Target Neighborhood Hits	949	Shared Neighborhood Hits	229
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LRC21_HUMAN
θ value	0.21417 (rank : 389)	NC score	0.353801 (rank : 228)
Query Neighborhood Hits	583	Target Neighborhood Hits	456	Shared Neighborhood Hits	234
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRC24_MOUSE
θ value	0.21417 (rank : 390)	NC score	0.255810 (rank : 321)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	186
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

NRG2_HUMAN
θ value	0.21417 (rank : 391)	NC score	0.500736 (rank : 155)
Query Neighborhood Hits	583	Target Neighborhood Hits	419	Shared Neighborhood Hits	237
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

NRG2_MOUSE
θ value	0.21417 (rank : 392)	NC score	0.494103 (rank : 159)
Query Neighborhood Hits	583	Target Neighborhood Hits	392	Shared Neighborhood Hits	237
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

SVIL_MOUSE
θ value	0.21417 (rank : 393)	NC score	0.017265 (rank : 1251)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

B4GN3_HUMAN
θ value	0.279714 (rank : 394)	NC score	0.012577 (rank : 1265)
Query Neighborhood Hits	583	Target Neighborhood Hits	128	Shared Neighborhood Hits	13
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

BT3A3_HUMAN
θ value	0.279714 (rank : 395)	NC score	0.081815 (rank : 650)
Query Neighborhood Hits	583	Target Neighborhood Hits	233	Shared Neighborhood Hits	115
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

CRLF1_HUMAN
θ value	0.279714 (rank : 396)	NC score	0.190378 (rank : 390)
Query Neighborhood Hits	583	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CRLF1_MOUSE
θ value	0.279714 (rank : 397)	NC score	0.182508 (rank : 394)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

IL6RA_MOUSE
θ value	0.279714 (rank : 398)	NC score	0.138697 (rank : 438)
Query Neighborhood Hits	583	Target Neighborhood Hits	104	Shared Neighborhood Hits	77
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

SIG12_MOUSE
θ value	0.279714 (rank : 399)	NC score	0.233450 (rank : 352)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	167
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

TRIM9_HUMAN
θ value	0.279714 (rank : 400)	NC score	0.075381 (rank : 675)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

IGS21_MOUSE
θ value	0.365318 (rank : 401)	NC score	0.262752 (rank : 313)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

PRG4_HUMAN
θ value	0.365318 (rank : 402)	NC score	0.032211 (rank : 1198)
Query Neighborhood Hits	583	Target Neighborhood Hits	764	Shared Neighborhood Hits	58
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

TREM2_HUMAN
θ value	0.365318 (rank : 403)	NC score	0.045046 (rank : 1180)
Query Neighborhood Hits	583	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

WASF2_HUMAN
θ value	0.365318 (rank : 404)	NC score	0.030914 (rank : 1202)
Query Neighborhood Hits	583	Target Neighborhood Hits	280	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

EMD_HUMAN
θ value	0.47712 (rank : 405)	NC score	0.022241 (rank : 1234)
Query Neighborhood Hits	583	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P50402	Gene names	EMD, EDMD, STA
Domain Architecture
Description	Emerin.

FCRL2_HUMAN
θ value	0.47712 (rank : 406)	NC score	0.530194 (rank : 151)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

GP116_HUMAN
θ value	0.47712 (rank : 407)	NC score	0.091733 (rank : 614)
Query Neighborhood Hits	583	Target Neighborhood Hits	167	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

HCFC2_HUMAN
θ value	0.47712 (rank : 408)	NC score	0.203733 (rank : 377)
Query Neighborhood Hits	583	Target Neighborhood Hits	154	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

IL1R1_MOUSE
θ value	0.47712 (rank : 409)	NC score	0.273315 (rank : 296)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	125
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

K1802_HUMAN
θ value	0.47712 (rank : 410)	NC score	0.011226 (rank : 1267)
Query Neighborhood Hits	583	Target Neighborhood Hits	1378	Shared Neighborhood Hits	69
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MFAP3_MOUSE
θ value	0.47712 (rank : 411)	NC score	0.151159 (rank : 416)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

PECA1_HUMAN
θ value	0.47712 (rank : 412)	NC score	0.315912 (rank : 267)
Query Neighborhood Hits	583	Target Neighborhood Hits	178	Shared Neighborhood Hits	149
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

SYNJ1_MOUSE
θ value	0.47712 (rank : 413)	NC score	0.023264 (rank : 1230)
Query Neighborhood Hits	583	Target Neighborhood Hits	516	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

UNC5A_MOUSE
θ value	0.47712 (rank : 414)	NC score	0.239803 (rank : 342)
Query Neighborhood Hits	583	Target Neighborhood Hits	203	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

WASF2_MOUSE
θ value	0.47712 (rank : 415)	NC score	0.029768 (rank : 1209)
Query Neighborhood Hits	583	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

AMGO1_HUMAN
θ value	0.62314 (rank : 416)	NC score	0.107693 (rank : 552)
Query Neighborhood Hits	583	Target Neighborhood Hits	353	Shared Neighborhood Hits	105
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

CSPG3_HUMAN
θ value	0.62314 (rank : 417)	NC score	0.024633 (rank : 1225)
Query Neighborhood Hits	583	Target Neighborhood Hits	676	Shared Neighborhood Hits	73
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

ENAH_MOUSE
θ value	0.62314 (rank : 418)	NC score	0.018416 (rank : 1247)
Query Neighborhood Hits	583	Target Neighborhood Hits	919	Shared Neighborhood Hits	41
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EPHA1_HUMAN
θ value	0.62314 (rank : 419)	NC score	0.181113 (rank : 395)
Query Neighborhood Hits	583	Target Neighborhood Hits	997	Shared Neighborhood Hits	144
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

IGS21_HUMAN
θ value	0.62314 (rank : 420)	NC score	0.263353 (rank : 311)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	108
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IL1AP_MOUSE
θ value	0.62314 (rank : 421)	NC score	0.105879 (rank : 564)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	57
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

PIGR_MOUSE
θ value	0.62314 (rank : 422)	NC score	0.296108 (rank : 281)
Query Neighborhood Hits	583	Target Neighborhood Hits	214	Shared Neighborhood Hits	154
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

UBQL4_MOUSE
θ value	0.62314 (rank : 423)	NC score	0.006841 (rank : 1281)
Query Neighborhood Hits	583	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

ZAN_HUMAN
θ value	0.62314 (rank : 424)	NC score	0.051457 (rank : 1138)
Query Neighborhood Hits	583	Target Neighborhood Hits	679	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

BT3A1_HUMAN
θ value	0.813845 (rank : 425)	NC score	0.080102 (rank : 662)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

CHCH6_MOUSE
θ value	0.813845 (rank : 426)	NC score	0.020271 (rank : 1244)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VN4	Gene names	Chchd6
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 6.

CILP1_HUMAN
θ value	0.813845 (rank : 427)	NC score	0.300337 (rank : 278)
Query Neighborhood Hits	583	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

MDC1_HUMAN
θ value	0.813845 (rank : 428)	NC score	0.041828 (rank : 1184)
Query Neighborhood Hits	583	Target Neighborhood Hits	1446	Shared Neighborhood Hits	95
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PGFRL_HUMAN
θ value	0.813845 (rank : 429)	NC score	0.272481 (rank : 299)
Query Neighborhood Hits	583	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PIGR_HUMAN
θ value	0.813845 (rank : 430)	NC score	0.268098 (rank : 303)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	115
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

SEM3C_MOUSE
θ value	0.813845 (rank : 431)	NC score	0.036269 (rank : 1193)
Query Neighborhood Hits	583	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

SIGL6_HUMAN
θ value	0.813845 (rank : 432)	NC score	0.333568 (rank : 246)
Query Neighborhood Hits	583	Target Neighborhood Hits	233	Shared Neighborhood Hits	206
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

SLAF9_HUMAN
θ value	0.813845 (rank : 433)	NC score	0.026766 (rank : 1220)
Query Neighborhood Hits	583	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q96A28, Q5JRQ9, Q5JRR0, Q6UWG1	Gene names	SLAMF9, CD2F10
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor (CD2 family member 10) (CD2F-10) (CD84 homolog 1) (CD84-H1).

BT3A2_HUMAN
θ value	1.06291 (rank : 434)	NC score	0.132459 (rank : 459)
Query Neighborhood Hits	583	Target Neighborhood Hits	158	Shared Neighborhood Hits	108
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

CXAR_HUMAN
θ value	1.06291 (rank : 435)	NC score	0.365435 (rank : 215)
Query Neighborhood Hits	583	Target Neighborhood Hits	245	Shared Neighborhood Hits	181
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

FPRP_HUMAN
θ value	1.06291 (rank : 436)	NC score	0.138862 (rank : 436)
Query Neighborhood Hits	583	Target Neighborhood Hits	130	Shared Neighborhood Hits	99
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

KCNQ4_HUMAN
θ value	1.06291 (rank : 437)	NC score	0.007043 (rank : 1280)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KIT_HUMAN
θ value	1.06291 (rank : 438)	NC score	0.253889 (rank : 324)
Query Neighborhood Hits	583	Target Neighborhood Hits	953	Shared Neighborhood Hits	219
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LDB3_MOUSE
θ value	1.06291 (rank : 439)	NC score	0.005900 (rank : 1283)
Query Neighborhood Hits	583	Target Neighborhood Hits	510	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LRC21_MOUSE
θ value	1.06291 (rank : 440)	NC score	0.358934 (rank : 221)
Query Neighborhood Hits	583	Target Neighborhood Hits	462	Shared Neighborhood Hits	238
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

NFAT5_HUMAN
θ value	1.06291 (rank : 441)	NC score	0.015303 (rank : 1258)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

PGRP3_HUMAN
θ value	1.06291 (rank : 442)	NC score	0.015185 (rank : 1259)
Query Neighborhood Hits	583	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LB9	Gene names	PGLYRP3, PGRPIA
Domain Architecture
Description	Peptidoglycan recognition protein I-alpha precursor (Peptidoglycan recognition protein intermediate alpha) (PGRP-I-alpha) (PGLYRPIalpha) (Peptidoglycan recognition protein 3).

PPRB_HUMAN
θ value	1.06291 (rank : 443)	NC score	0.027399 (rank : 1218)
Query Neighborhood Hits	583	Target Neighborhood Hits	311	Shared Neighborhood Hits	23
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

SHPS1_HUMAN
θ value	1.06291 (rank : 444)	NC score	0.174190 (rank : 402)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	120
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SIGL7_HUMAN
θ value	1.06291 (rank : 445)	NC score	0.250169 (rank : 330)
Query Neighborhood Hits	583	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

TACC3_HUMAN
θ value	1.06291 (rank : 446)	NC score	0.003497 (rank : 1296)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TAU_HUMAN
θ value	1.06291 (rank : 447)	NC score	0.030497 (rank : 1206)
Query Neighborhood Hits	583	Target Neighborhood Hits	448	Shared Neighborhood Hits	44
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

YETS2_MOUSE
θ value	1.06291 (rank : 448)	NC score	0.022220 (rank : 1235)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	34
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

BTNL2_HUMAN
θ value	1.38821 (rank : 449)	NC score	0.149370 (rank : 419)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

CD2L1_MOUSE
θ value	1.38821 (rank : 450)	NC score	0.051931 (rank : 1123)
Query Neighborhood Hits	583	Target Neighborhood Hits	1463	Shared Neighborhood Hits	97
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

ENAM_HUMAN
θ value	1.38821 (rank : 451)	NC score	0.030433 (rank : 1207)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

I12R1_HUMAN
θ value	1.38821 (rank : 452)	NC score	0.160457 (rank : 409)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

IGF1R_HUMAN
θ value	1.38821 (rank : 453)	NC score	0.195584 (rank : 384)
Query Neighborhood Hits	583	Target Neighborhood Hits	977	Shared Neighborhood Hits	149
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

K0310_HUMAN
θ value	1.38821 (rank : 454)	NC score	0.029109 (rank : 1212)
Query Neighborhood Hits	583	Target Neighborhood Hits	420	Shared Neighborhood Hits	44
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

LIRB3_HUMAN
θ value	1.38821 (rank : 455)	NC score	0.021033 (rank : 1242)
Query Neighborhood Hits	583	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	O75022, O15471, Q86U49	Gene names	LILRB3, ILT5, LIR3
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor (Leukocyte immunoglobulin-like receptor 3) (LIR-3) (Immunoglobulin- like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD85a antigen).

SAM68_MOUSE
θ value	1.38821 (rank : 456)	NC score	0.022842 (rank : 1232)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

SIRB1_HUMAN
θ value	1.38821 (rank : 457)	NC score	0.157910 (rank : 410)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	113
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

SLAF8_MOUSE
θ value	1.38821 (rank : 458)	NC score	0.072259 (rank : 690)
Query Neighborhood Hits	583	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

TIMD1_MOUSE
θ value	1.38821 (rank : 459)	NC score	0.058869 (rank : 896)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

AMGO1_MOUSE
θ value	1.81305 (rank : 460)	NC score	0.089689 (rank : 622)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	83
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

CSKI1_MOUSE
θ value	1.81305 (rank : 461)	NC score	0.021139 (rank : 1240)
Query Neighborhood Hits	583	Target Neighborhood Hits	1031	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FCGR1_HUMAN
θ value	1.81305 (rank : 462)	NC score	0.189995 (rank : 391)
Query Neighborhood Hits	583	Target Neighborhood Hits	145	Shared Neighborhood Hits	106
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

GGN_MOUSE
θ value	1.81305 (rank : 463)	NC score	0.023908 (rank : 1226)
Query Neighborhood Hits	583	Target Neighborhood Hits	311	Shared Neighborhood Hits	31
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

IGF1R_MOUSE
θ value	1.81305 (rank : 464)	NC score	0.194117 (rank : 385)
Query Neighborhood Hits	583	Target Neighborhood Hits	973	Shared Neighborhood Hits	147
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGSF8_MOUSE
θ value	1.81305 (rank : 465)	NC score	0.081592 (rank : 654)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

ILRL2_MOUSE
θ value	1.81305 (rank : 466)	NC score	0.272511 (rank : 298)
Query Neighborhood Hits	583	Target Neighborhood Hits	158	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

MTFR1_MOUSE
θ value	1.81305 (rank : 467)	NC score	0.022212 (rank : 1236)
Query Neighborhood Hits	583	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

NCOA6_HUMAN
θ value	1.81305 (rank : 468)	NC score	0.028666 (rank : 1215)
Query Neighborhood Hits	583	Target Neighborhood Hits	1202	Shared Neighborhood Hits	88
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCOA6_MOUSE
θ value	1.81305 (rank : 469)	NC score	0.025619 (rank : 1222)
Query Neighborhood Hits	583	Target Neighborhood Hits	1076	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NRG1_HUMAN
θ value	1.81305 (rank : 470)	NC score	0.346531 (rank : 234)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	164
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

PGFRL_MOUSE
θ value	1.81305 (rank : 471)	NC score	0.237330 (rank : 345)
Query Neighborhood Hits	583	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PRG4_MOUSE
θ value	1.81305 (rank : 472)	NC score	0.031220 (rank : 1201)
Query Neighborhood Hits	583	Target Neighborhood Hits	624	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PTPRG_HUMAN
θ value	1.81305 (rank : 473)	NC score	0.138852 (rank : 437)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	66
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

PTPRG_MOUSE
θ value	1.81305 (rank : 474)	NC score	0.137624 (rank : 440)
Query Neighborhood Hits	583	Target Neighborhood Hits	260	Shared Neighborhood Hits	63
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

SF3A1_HUMAN
θ value	1.81305 (rank : 475)	NC score	0.025378 (rank : 1224)
Query Neighborhood Hits	583	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SF3A1_MOUSE
θ value	1.81305 (rank : 476)	NC score	0.023348 (rank : 1229)
Query Neighborhood Hits	583	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

ZPBP1_HUMAN
θ value	1.81305 (rank : 477)	NC score	0.031698 (rank : 1200)
Query Neighborhood Hits	583	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BS86, Q15941, Q75KX9, Q75MI3	Gene names	ZPBP, ZPBP1
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 1 precursor (Sp38).

CCAR1_MOUSE
θ value	2.36792 (rank : 478)	NC score	0.007538 (rank : 1276)
Query Neighborhood Hits	583	Target Neighborhood Hits	414	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

DSG1C_MOUSE
θ value	2.36792 (rank : 479)	NC score	-0.003277 (rank : 1309)
Query Neighborhood Hits	583	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TSF0, Q7TQ61	Gene names	Dsg1c, Dsg6
Domain Architecture	No domain graphic available
Description	Desmoglein-1 gamma precursor (Dsg1-gamma) (Desmoglein-6).

ERMAP_MOUSE
θ value	2.36792 (rank : 480)	NC score	0.039294 (rank : 1186)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

IGX1_MOUSE
θ value	2.36792 (rank : 481)	NC score	0.022801 (rank : 1233)
Query Neighborhood Hits	583	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0A6	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

KV1M_HUMAN
θ value	2.36792 (rank : 482)	NC score	0.003955 (rank : 1294)
Query Neighborhood Hits	583	Target Neighborhood Hits	249	Shared Neighborhood Hits	29
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

NACAM_MOUSE
θ value	2.36792 (rank : 483)	NC score	0.052038 (rank : 1119)
Query Neighborhood Hits	583	Target Neighborhood Hits	1866	Shared Neighborhood Hits	137
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PCDA5_HUMAN
θ value	2.36792 (rank : 484)	NC score	-0.003786 (rank : 1310)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

PPRB_MOUSE
θ value	2.36792 (rank : 485)	NC score	0.017377 (rank : 1249)
Query Neighborhood Hits	583	Target Neighborhood Hits	354	Shared Neighborhood Hits	27
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

TRIM9_MOUSE
θ value	2.36792 (rank : 486)	NC score	0.067055 (rank : 739)
Query Neighborhood Hits	583	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

TTBK1_HUMAN
θ value	2.36792 (rank : 487)	NC score	0.026817 (rank : 1219)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	70
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

UN13A_HUMAN
θ value	2.36792 (rank : 488)	NC score	0.003492 (rank : 1297)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ZEP1_MOUSE
θ value	2.36792 (rank : 489)	NC score	-0.006731 (rank : 1314)
Query Neighborhood Hits	583	Target Neighborhood Hits	1063	Shared Neighborhood Hits	40
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

3BP2_MOUSE
θ value	3.0926 (rank : 490)	NC score	0.016660 (rank : 1255)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CD48_MOUSE
θ value	3.0926 (rank : 491)	NC score	0.121363 (rank : 491)
Query Neighborhood Hits	583	Target Neighborhood Hits	96	Shared Neighborhood Hits	63
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

CILP1_MOUSE
θ value	3.0926 (rank : 492)	NC score	0.321526 (rank : 259)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	190
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ESX1L_HUMAN
θ value	3.0926 (rank : 493)	NC score	0.002301 (rank : 1302)
Query Neighborhood Hits	583	Target Neighborhood Hits	498	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

HCN2_MOUSE
θ value	3.0926 (rank : 494)	NC score	0.004211 (rank : 1291)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	23
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

LV5A_HUMAN
θ value	3.0926 (rank : 495)	NC score	0.010867 (rank : 1269)
Query Neighborhood Hits	583	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	P01719	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-V region DEL.

MTFR1_HUMAN
θ value	3.0926 (rank : 496)	NC score	0.017185 (rank : 1252)
Query Neighborhood Hits	583	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q15390, Q6IB94, Q86XH5, Q8IVD7	Gene names	MTFR1, CHPPR, KIAA0009
Domain Architecture
Description	Mitochondrial fission regulator 1 (Chondrocyte protein with a poly- proline region).

POLH_MOUSE
θ value	3.0926 (rank : 497)	NC score	0.014174 (rank : 1263)
Query Neighborhood Hits	583	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

TIMD4_MOUSE
θ value	3.0926 (rank : 498)	NC score	0.034188 (rank : 1197)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	Q6U7R4, Q6U7R3, Q8CIC7	Gene names	Timd4, Tim4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4) (Spleen, mucin- containing, knockout of lymphotoxin protein) (SMUCKLER).

WBS14_HUMAN
θ value	3.0926 (rank : 499)	NC score	0.023514 (rank : 1228)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ZF106_MOUSE
θ value	3.0926 (rank : 500)	NC score	-0.001336 (rank : 1307)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

CD276_MOUSE
θ value	4.03905 (rank : 501)	NC score	0.306906 (rank : 275)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	182
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CEP68_HUMAN
θ value	4.03905 (rank : 502)	NC score	0.012613 (rank : 1264)
Query Neighborhood Hits	583	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CXAR_MOUSE
θ value	4.03905 (rank : 503)	NC score	0.353028 (rank : 230)
Query Neighborhood Hits	583	Target Neighborhood Hits	250	Shared Neighborhood Hits	184
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

EVI2B_HUMAN
θ value	4.03905 (rank : 504)	NC score	0.015110 (rank : 1260)
Query Neighborhood Hits	583	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

FANK1_HUMAN
θ value	4.03905 (rank : 505)	NC score	0.030376 (rank : 1208)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

FCG3A_HUMAN
θ value	4.03905 (rank : 506)	NC score	0.069653 (rank : 709)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	49
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

FRM4B_MOUSE
θ value	4.03905 (rank : 507)	NC score	-0.000651 (rank : 1304)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

JAML1_HUMAN
θ value	4.03905 (rank : 508)	NC score	0.130748 (rank : 465)
Query Neighborhood Hits	583	Target Neighborhood Hits	108	Shared Neighborhood Hits	77
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

LDB3_HUMAN
θ value	4.03905 (rank : 509)	NC score	0.003946 (rank : 1295)
Query Neighborhood Hits	583	Target Neighborhood Hits	497	Shared Neighborhood Hits	35
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

NP1L3_HUMAN
θ value	4.03905 (rank : 510)	NC score	0.004708 (rank : 1288)
Query Neighborhood Hits	583	Target Neighborhood Hits	172	Shared Neighborhood Hits	8
SwissProt Accessions	Q99457, O60788	Gene names	NAP1L3, BNAP
Domain Architecture
Description	Nucleosome assembly protein 1-like 3.

PDL1_MOUSE
θ value	4.03905 (rank : 511)	NC score	0.237066 (rank : 346)
Query Neighborhood Hits	583	Target Neighborhood Hits	168	Shared Neighborhood Hits	136
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

RGS3_MOUSE
θ value	4.03905 (rank : 512)	NC score	0.028992 (rank : 1213)
Query Neighborhood Hits	583	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SEM3F_MOUSE
θ value	4.03905 (rank : 513)	NC score	0.018408 (rank : 1248)
Query Neighborhood Hits	583	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	O88632, O88633	Gene names	Sema3f
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV).

WBS14_MOUSE
θ value	4.03905 (rank : 514)	NC score	0.030639 (rank : 1203)
Query Neighborhood Hits	583	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

BT2A2_HUMAN
θ value	5.27518 (rank : 515)	NC score	0.029561 (rank : 1211)
Query Neighborhood Hits	583	Target Neighborhood Hits	191	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

CD80_HUMAN
θ value	5.27518 (rank : 516)	NC score	0.202045 (rank : 379)
Query Neighborhood Hits	583	Target Neighborhood Hits	129	Shared Neighborhood Hits	108
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CI106_HUMAN
θ value	5.27518 (rank : 517)	NC score	0.016518 (rank : 1256)
Query Neighborhood Hits	583	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NAJ2	Gene names	C9orf106
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C9orf106.

CNOT4_HUMAN
θ value	5.27518 (rank : 518)	NC score	0.005552 (rank : 1284)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CRLF2_MOUSE
θ value	5.27518 (rank : 519)	NC score	0.056220 (rank : 982)
Query Neighborhood Hits	583	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

EPN1_HUMAN
θ value	5.27518 (rank : 520)	NC score	0.011042 (rank : 1268)
Query Neighborhood Hits	583	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

FANK1_MOUSE
θ value	5.27518 (rank : 521)	NC score	0.028684 (rank : 1214)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

FCGR1_MOUSE
θ value	5.27518 (rank : 522)	NC score	0.152811 (rank : 415)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	90
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

FIP1_HUMAN
θ value	5.27518 (rank : 523)	NC score	0.014579 (rank : 1262)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

ICOSL_HUMAN
θ value	5.27518 (rank : 524)	NC score	0.072334 (rank : 689)
Query Neighborhood Hits	583	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

IL1AP_HUMAN
θ value	5.27518 (rank : 525)	NC score	0.087518 (rank : 631)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

KV1H_HUMAN
θ value	5.27518 (rank : 526)	NC score	0.002996 (rank : 1299)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	P01600	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Hau.

KV5D_MOUSE
θ value	5.27518 (rank : 527)	NC score	0.007497 (rank : 1277)
Query Neighborhood Hits	583	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	P01636	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 149.

LRP10_HUMAN
θ value	5.27518 (rank : 528)	NC score	0.035500 (rank : 1194)
Query Neighborhood Hits	583	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

P3C2A_HUMAN
θ value	5.27518 (rank : 529)	NC score	0.002691 (rank : 1301)
Query Neighborhood Hits	583	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PCDA2_HUMAN
θ value	5.27518 (rank : 530)	NC score	-0.004073 (rank : 1312)
Query Neighborhood Hits	583	Target Neighborhood Hits	192	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

PCDA8_HUMAN
θ value	5.27518 (rank : 531)	NC score	-0.004069 (rank : 1311)
Query Neighborhood Hits	583	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5H6, O75281	Gene names	PCDHA8
Domain Architecture
Description	Protocadherin alpha 8 precursor (PCDH-alpha8).

PDL1_HUMAN
θ value	5.27518 (rank : 532)	NC score	0.291853 (rank : 284)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PGCA_MOUSE
θ value	5.27518 (rank : 533)	NC score	0.026566 (rank : 1221)
Query Neighborhood Hits	583	Target Neighborhood Hits	643	Shared Neighborhood Hits	90
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

SAM68_HUMAN
θ value	5.27518 (rank : 534)	NC score	0.016777 (rank : 1254)
Query Neighborhood Hits	583	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

SEM3C_HUMAN
θ value	5.27518 (rank : 535)	NC score	0.030587 (rank : 1205)
Query Neighborhood Hits	583	Target Neighborhood Hits	106	Shared Neighborhood Hits	51
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

SIN3A_HUMAN
θ value	5.27518 (rank : 536)	NC score	0.010426 (rank : 1270)
Query Neighborhood Hits	583	Target Neighborhood Hits	180	Shared Neighborhood Hits	18
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SMAD6_HUMAN
θ value	5.27518 (rank : 537)	NC score	0.007992 (rank : 1274)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

TIMD1_HUMAN
θ value	5.27518 (rank : 538)	NC score	0.062556 (rank : 805)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

TPSNR_MOUSE
θ value	5.27518 (rank : 539)	NC score	0.129198 (rank : 469)
Query Neighborhood Hits	583	Target Neighborhood Hits	336	Shared Neighborhood Hits	115
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

WNK2_HUMAN
θ value	5.27518 (rank : 540)	NC score	0.050493 (rank : 1168)
Query Neighborhood Hits	583	Target Neighborhood Hits	1407	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

BRD3_HUMAN
θ value	6.88961 (rank : 541)	NC score	0.004971 (rank : 1287)
Query Neighborhood Hits	583	Target Neighborhood Hits	369	Shared Neighborhood Hits	24
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

BTNL1_MOUSE
θ value	6.88961 (rank : 542)	NC score	0.096850 (rank : 592)
Query Neighborhood Hits	583	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

EGR2_MOUSE
θ value	6.88961 (rank : 543)	NC score	-0.014085 (rank : 1315)
Query Neighborhood Hits	583	Target Neighborhood Hits	745	Shared Neighborhood Hits	12
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

HECD2_HUMAN
θ value	6.88961 (rank : 544)	NC score	-0.001001 (rank : 1305)
Query Neighborhood Hits	583	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

IF35_MOUSE
θ value	6.88961 (rank : 545)	NC score	0.016779 (rank : 1253)
Query Neighborhood Hits	583	Target Neighborhood Hits	210	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IGSF2_HUMAN
θ value	6.88961 (rank : 546)	NC score	0.140540 (rank : 432)
Query Neighborhood Hits	583	Target Neighborhood Hits	208	Shared Neighborhood Hits	109
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

MAGE1_HUMAN
θ value	6.88961 (rank : 547)	NC score	0.028194 (rank : 1216)
Query Neighborhood Hits	583	Target Neighborhood Hits	1389	Shared Neighborhood Hits	111
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MLL3_MOUSE
θ value	6.88961 (rank : 548)	NC score	0.009829 (rank : 1271)
Query Neighborhood Hits	583	Target Neighborhood Hits	1399	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NFRKB_MOUSE
θ value	6.88961 (rank : 549)	NC score	0.019849 (rank : 1245)
Query Neighborhood Hits	583	Target Neighborhood Hits	393	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

PDL2_MOUSE
θ value	6.88961 (rank : 550)	NC score	0.233141 (rank : 353)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PGCB_MOUSE
θ value	6.88961 (rank : 551)	NC score	0.011481 (rank : 1266)
Query Neighborhood Hits	583	Target Neighborhood Hits	459	Shared Neighborhood Hits	44
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.

PKN3_HUMAN
θ value	6.88961 (rank : 552)	NC score	0.059222 (rank : 887)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	94
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PTN23_MOUSE
θ value	6.88961 (rank : 553)	NC score	0.096795 (rank : 593)
Query Neighborhood Hits	583	Target Neighborhood Hits	726	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SHPS1_MOUSE
θ value	6.88961 (rank : 554)	NC score	0.112624 (rank : 537)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	107
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

SOX30_HUMAN
θ value	6.88961 (rank : 555)	NC score	0.007798 (rank : 1275)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	35
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

TACC2_MOUSE
θ value	6.88961 (rank : 556)	NC score	0.004075 (rank : 1292)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

US6NL_HUMAN
θ value	6.88961 (rank : 557)	NC score	0.005187 (rank : 1285)
Query Neighborhood Hits	583	Target Neighborhood Hits	201	Shared Neighborhood Hits	18
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

VPREB_HUMAN
θ value	6.88961 (rank : 558)	NC score	0.000950 (rank : 1303)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	P12018	Gene names	VPREB1, VPREB
Domain Architecture
Description	Immunoglobulin iota chain precursor (V(pre)B protein) (VpreB protein) (CD179a antigen).

WASIP_HUMAN
θ value	6.88961 (rank : 559)	NC score	0.021305 (rank : 1238)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	32
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

XRN1_MOUSE
θ value	6.88961 (rank : 560)	NC score	0.003467 (rank : 1298)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

YLPM1_MOUSE
θ value	6.88961 (rank : 561)	NC score	0.020766 (rank : 1243)
Query Neighborhood Hits	583	Target Neighborhood Hits	505	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZPBP2_MOUSE
θ value	6.88961 (rank : 562)	NC score	0.017374 (rank : 1250)
Query Neighborhood Hits	583	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q6X786, Q6X785, Q9DA91	Gene names	Zpbp2
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor.

AFF4_MOUSE
θ value	8.99809 (rank : 563)	NC score	0.005140 (rank : 1286)
Query Neighborhood Hits	583	Target Neighborhood Hits	581	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

BCOR_HUMAN
θ value	8.99809 (rank : 564)	NC score	0.002894 (rank : 1300)
Query Neighborhood Hits	583	Target Neighborhood Hits	609	Shared Neighborhood Hits	40
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

BRCA1_HUMAN
θ value	8.99809 (rank : 565)	NC score	-0.004253 (rank : 1313)
Query Neighborhood Hits	583	Target Neighborhood Hits	381	Shared Neighborhood Hits	10
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

CREB5_HUMAN
θ value	8.99809 (rank : 566)	NC score	0.007259 (rank : 1279)
Query Neighborhood Hits	583	Target Neighborhood Hits	222	Shared Neighborhood Hits	8
SwissProt Accessions	Q02930, Q05886, Q06246	Gene names	CREB5, CREBPA
Domain Architecture
Description	cAMP response element-binding protein 5 (CRE-BPa).

CUTL2_MOUSE
θ value	8.99809 (rank : 567)	NC score	0.004326 (rank : 1289)
Query Neighborhood Hits	583	Target Neighborhood Hits	771	Shared Neighborhood Hits	27
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ERMAP_HUMAN
θ value	8.99809 (rank : 568)	NC score	0.014876 (rank : 1261)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

F113A_HUMAN
θ value	8.99809 (rank : 569)	NC score	0.007390 (rank : 1278)
Query Neighborhood Hits	583	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H1Q7, Q5JUA5, Q5JUA6, Q6PK19, Q86WF5, Q96CG7, Q9H1Q6, Q9H6D1	Gene names	FAM113A, C20orf81
Domain Architecture	No domain graphic available
Description	Protein FAM113A (Sarcoma antigen NY-SAR-23).

FA47A_HUMAN
θ value	8.99809 (rank : 570)	NC score	0.023550 (rank : 1227)
Query Neighborhood Hits	583	Target Neighborhood Hits	451	Shared Neighborhood Hits	45
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GSCR1_HUMAN
θ value	8.99809 (rank : 571)	NC score	0.027618 (rank : 1217)
Query Neighborhood Hits	583	Target Neighborhood Hits	674	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

IC1_MOUSE
θ value	8.99809 (rank : 572)	NC score	-0.003085 (rank : 1308)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	14
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

LARP1_HUMAN
θ value	8.99809 (rank : 573)	NC score	0.008390 (rank : 1273)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

MKL2_MOUSE
θ value	8.99809 (rank : 574)	NC score	0.006017 (rank : 1282)
Query Neighborhood Hits	583	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

NOTC2_HUMAN
θ value	8.99809 (rank : 575)	NC score	0.029717 (rank : 1210)
Query Neighborhood Hits	583	Target Neighborhood Hits	1113	Shared Neighborhood Hits	94
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PGCB_HUMAN
θ value	8.99809 (rank : 576)	NC score	0.009749 (rank : 1272)
Query Neighborhood Hits	583	Target Neighborhood Hits	478	Shared Neighborhood Hits	44
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

PVRL2_HUMAN
θ value	8.99809 (rank : 577)	NC score	0.232678 (rank : 354)
Query Neighborhood Hits	583	Target Neighborhood Hits	185	Shared Neighborhood Hits	129
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

RAPH1_HUMAN
θ value	8.99809 (rank : 578)	NC score	0.021250 (rank : 1239)
Query Neighborhood Hits	583	Target Neighborhood Hits	593	Shared Neighborhood Hits	42
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RU1C_MOUSE
θ value	8.99809 (rank : 579)	NC score	0.018434 (rank : 1246)
Query Neighborhood Hits	583	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

SCYB5_MOUSE
θ value	8.99809 (rank : 580)	NC score	0.004297 (rank : 1290)
Query Neighborhood Hits	583	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P50228	Gene names	Cxcl5, Scyb5
Domain Architecture
Description	Small inducible cytokine B5 precursor (CXCL5) (Cytokine LIX) [Contains: GCP-2(1-78); GCP-2(9-78)].

TIMD2_MOUSE
θ value	8.99809 (rank : 581)	NC score	0.042958 (rank : 1182)
Query Neighborhood Hits	583	Target Neighborhood Hits	51	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

TIMD3_MOUSE
θ value	8.99809 (rank : 582)	NC score	0.039530 (rank : 1185)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VIM0	Gene names	Havcr2, Tim3, Timd3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 homolog precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

VPRE2_MOUSE
θ value	8.99809 (rank : 583)	NC score	-0.001213 (rank : 1306)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	P13373	Gene names	Vpreb2
Domain Architecture
Description	Immunoglobulin omega chain precursor (VpreB2 protein).

A1BG_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.079272 (rank : 666)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

A2GL_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.055239 (rank : 1019)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

AAPK1_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.061252 (rank : 835)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.061012 (rank : 841)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	89
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.059143 (rank : 890)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AATK_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.132853 (rank : 457)
Query Neighborhood Hits	583	Target Neighborhood Hits	1243	Shared Neighborhood Hits	124
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.135631 (rank : 442)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	105
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.118981 (rank : 499)
Query Neighborhood Hits	583	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.119969 (rank : 496)
Query Neighborhood Hits	583	Target Neighborhood Hits	1178	Shared Neighborhood Hits	104
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.118816 (rank : 500)
Query Neighborhood Hits	583	Target Neighborhood Hits	1045	Shared Neighborhood Hits	91
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.133484 (rank : 453)
Query Neighborhood Hits	583	Target Neighborhood Hits	1140	Shared Neighborhood Hits	120
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.134708 (rank : 448)
Query Neighborhood Hits	583	Target Neighborhood Hits	1080	Shared Neighborhood Hits	118
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.060972 (rank : 844)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.061372 (rank : 827)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.067094 (rank : 737)
Query Neighborhood Hits	583	Target Neighborhood Hits	709	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 599)	NC score	0.062137 (rank : 812)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 600)	NC score	0.075002 (rank : 677)
Query Neighborhood Hits	583	Target Neighborhood Hits	716	Shared Neighborhood Hits	80
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.078244 (rank : 668)
Query Neighborhood Hits	583	Target Neighborhood Hits	739	Shared Neighborhood Hits	81
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.065330 (rank : 760)
Query Neighborhood Hits	583	Target Neighborhood Hits	760	Shared Neighborhood Hits	84
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 603)	NC score	0.066213 (rank : 751)
Query Neighborhood Hits	583	Target Neighborhood Hits	768	Shared Neighborhood Hits	84
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AGRIN_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.055976 (rank : 993)
Query Neighborhood Hits	583	Target Neighborhood Hits	582	Shared Neighborhood Hits	53
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AKT2_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.050416 (rank : 1171)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	88
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.050112 (rank : 1176)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AL2S2_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.052282 (rank : 1114)
Query Neighborhood Hits	583	Target Neighborhood Hits	709	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.055414 (rank : 1012)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	87
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.147682 (rank : 422)
Query Neighborhood Hits	583	Target Neighborhood Hits	795	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.148940 (rank : 420)
Query Neighborhood Hits	583	Target Neighborhood Hits	811	Shared Neighborhood Hits	96
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALS_HUMAN
θ value	θ > 10 (rank : 611)	NC score	0.062243 (rank : 809)
Query Neighborhood Hits	583	Target Neighborhood Hits	280	Shared Neighborhood Hits	39
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

ALS_MOUSE
θ value	θ > 10 (rank : 612)	NC score	0.060771 (rank : 852)
Query Neighborhood Hits	583	Target Neighborhood Hits	275	Shared Neighborhood Hits	37
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

AMGO2_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.134305 (rank : 450)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	129
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

AMGO2_MOUSE
θ value	θ > 10 (rank : 614)	NC score	0.113412 (rank : 534)
Query Neighborhood Hits	583	Target Neighborhood Hits	329	Shared Neighborhood Hits	101
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

AMHR2_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.059404 (rank : 881)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.065494 (rank : 756)
Query Neighborhood Hits	583	Target Neighborhood Hits	1075	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.068103 (rank : 721)
Query Neighborhood Hits	583	Target Neighborhood Hits	1072	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANPRA_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.080319 (rank : 661)
Query Neighborhood Hits	583	Target Neighborhood Hits	612	Shared Neighborhood Hits	81
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.080382 (rank : 660)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	81
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.075296 (rank : 676)
Query Neighborhood Hits	583	Target Neighborhood Hits	646	Shared Neighborhood Hits	81
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.074241 (rank : 681)
Query Neighborhood Hits	583	Target Neighborhood Hits	607	Shared Neighborhood Hits	81
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARAF_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.096002 (rank : 598)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	94
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.096243 (rank : 595)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ASPN_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.054871 (rank : 1034)
Query Neighborhood Hits	583	Target Neighborhood Hits	274	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

ASPN_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.055479 (rank : 1007)
Query Neighborhood Hits	583	Target Neighborhood Hits	277	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

AURKB_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.061920 (rank : 815)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 627)	NC score	0.060103 (rank : 866)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.062806 (rank : 799)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 629)	NC score	0.061943 (rank : 814)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AVR2A_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.061310 (rank : 831)
Query Neighborhood Hits	583	Target Neighborhood Hits	767	Shared Neighborhood Hits	83
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 631)	NC score	0.061311 (rank : 830)
Query Neighborhood Hits	583	Target Neighborhood Hits	767	Shared Neighborhood Hits	83
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BLK_HUMAN
θ value	θ > 10 (rank : 632)	NC score	0.117125 (rank : 517)
Query Neighborhood Hits	583	Target Neighborhood Hits	994	Shared Neighborhood Hits	89
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.118344 (rank : 505)
Query Neighborhood Hits	583	Target Neighborhood Hits	992	Shared Neighborhood Hits	89
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMPR2_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.064931 (rank : 764)
Query Neighborhood Hits	583	Target Neighborhood Hits	736	Shared Neighborhood Hits	83
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.063171 (rank : 794)
Query Neighborhood Hits	583	Target Neighborhood Hits	738	Shared Neighborhood Hits	84
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 636)	NC score	0.067211 (rank : 735)
Query Neighborhood Hits	583	Target Neighborhood Hits	759	Shared Neighborhood Hits	86
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.067005 (rank : 741)
Query Neighborhood Hits	583	Target Neighborhood Hits	758	Shared Neighborhood Hits	85
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.066489 (rank : 746)
Query Neighborhood Hits	583	Target Neighborhood Hits	760	Shared Neighborhood Hits	84
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.067761 (rank : 725)
Query Neighborhood Hits	583	Target Neighborhood Hits	758	Shared Neighborhood Hits	84
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMX_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.119326 (rank : 498)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.120286 (rank : 495)
Query Neighborhood Hits	583	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.095973 (rank : 599)
Query Neighborhood Hits	583	Target Neighborhood Hits	883	Shared Neighborhood Hits	91
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

BRSK1_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.053893 (rank : 1069)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.054034 (rank : 1062)
Query Neighborhood Hits	583	Target Neighborhood Hits	897	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

BT1A1_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.094012 (rank : 607)
Query Neighborhood Hits	583	Target Neighborhood Hits	322	Shared Neighborhood Hits	127
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BTK_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.118276 (rank : 506)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	90
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.118187 (rank : 508)
Query Neighborhood Hits	583	Target Neighborhood Hits	1017	Shared Neighborhood Hits	90
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CCRK_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.053516 (rank : 1085)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.051417 (rank : 1141)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD180_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.052427 (rank : 1111)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	34
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

CD180_MOUSE
θ value	θ > 10 (rank : 651)	NC score	0.055985 (rank : 992)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

CD226_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.097594 (rank : 590)
Query Neighborhood Hits	583	Target Neighborhood Hits	87	Shared Neighborhood Hits	68
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

CD226_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.064519 (rank : 770)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

CD244_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.086444 (rank : 636)
Query Neighborhood Hits	583	Target Neighborhood Hits	72	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

CD2L5_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.061323 (rank : 829)
Query Neighborhood Hits	583	Target Neighborhood Hits	987	Shared Neighborhood Hits	95
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.061393 (rank : 826)
Query Neighborhood Hits	583	Target Neighborhood Hits	1011	Shared Neighborhood Hits	96
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.065652 (rank : 754)
Query Neighborhood Hits	583	Target Neighborhood Hits	1275	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD33_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.067894 (rank : 723)
Query Neighborhood Hits	583	Target Neighborhood Hits	50	Shared Neighborhood Hits	36
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

CD33_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.063613 (rank : 788)
Query Neighborhood Hits	583	Target Neighborhood Hits	45	Shared Neighborhood Hits	31
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

CD48_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.093089 (rank : 612)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

CD79A_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.174752 (rank : 401)
Query Neighborhood Hits	583	Target Neighborhood Hits	102	Shared Neighborhood Hits	66
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD79B_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.055354 (rank : 1015)
Query Neighborhood Hits	583	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CD80_MOUSE
θ value	θ > 10 (rank : 663)	NC score	0.195857 (rank : 383)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CD86_HUMAN
θ value	θ > 10 (rank : 664)	NC score	0.066888 (rank : 742)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

CD86_MOUSE
θ value	θ > 10 (rank : 665)	NC score	0.068962 (rank : 714)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

CDC2_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.058777 (rank : 900)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	87
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDC2_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.058452 (rank : 910)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK10_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.051616 (rank : 1131)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CDK2_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.059425 (rank : 878)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK2_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.059362 (rank : 882)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.060670 (rank : 854)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	87
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK3_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.056020 (rank : 991)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	87
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.064034 (rank : 779)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	88
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	θ > 10 (rank : 674)	NC score	0.065201 (rank : 761)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	88
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDK5_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.057392 (rank : 943)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	85
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.057489 (rank : 940)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	85
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDK6_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.064343 (rank : 772)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	88
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK6_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.064649 (rank : 767)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	88
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK7_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.058666 (rank : 905)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.059089 (rank : 891)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK9_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.054923 (rank : 1031)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.054694 (rank : 1042)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDKL1_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.052601 (rank : 1106)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	86
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.051822 (rank : 1125)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.059041 (rank : 892)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL2_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.057077 (rank : 951)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	87
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL3_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.056034 (rank : 990)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.055509 (rank : 1005)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL4_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.055343 (rank : 1016)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	86
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL4_MOUSE
θ value	θ > 10 (rank : 690)	NC score	0.057967 (rank : 926)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	86
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	θ > 10 (rank : 691)	NC score	0.053980 (rank : 1065)
Query Neighborhood Hits	583	Target Neighborhood Hits	967	Shared Neighborhood Hits	97
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CEA19_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.074104 (rank : 682)
Query Neighborhood Hits	583	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

CEAM3_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.120494 (rank : 493)
Query Neighborhood Hits	583	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

CEAMA_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.122646 (rank : 487)
Query Neighborhood Hits	583	Target Neighborhood Hits	41	Shared Neighborhood Hits	36
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

CHAD_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.065067 (rank : 762)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	37
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHAD_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.063418 (rank : 790)
Query Neighborhood Hits	583	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

CHK1_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.054186 (rank : 1054)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.054079 (rank : 1059)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	87
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CI096_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.053381 (rank : 1089)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CNTFR_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.067056 (rank : 738)
Query Neighborhood Hits	583	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CNTFR_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.069268 (rank : 711)
Query Neighborhood Hits	583	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CPN2_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.060473 (rank : 856)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CPN2_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.059279 (rank : 884)
Query Neighborhood Hits	583	Target Neighborhood Hits	291	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

CSF3R_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.251861 (rank : 328)
Query Neighborhood Hits	583	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSK_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.117274 (rank : 516)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.115490 (rank : 526)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT075_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.179273 (rank : 397)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	117
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

CT075_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.144068 (rank : 424)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	97
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

DAPK1_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.058545 (rank : 908)
Query Neighborhood Hits	583	Target Neighborhood Hits	1130	Shared Neighborhood Hits	101
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.058051 (rank : 922)
Query Neighborhood Hits	583	Target Neighborhood Hits	1138	Shared Neighborhood Hits	101
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.066800 (rank : 743)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.067049 (rank : 740)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.067126 (rank : 736)
Query Neighborhood Hits	583	Target Neighborhood Hits	945	Shared Neighborhood Hits	88
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.066606 (rank : 745)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.054974 (rank : 1030)
Query Neighborhood Hits	583	Target Neighborhood Hits	877	Shared Neighborhood Hits	90
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.054806 (rank : 1035)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.050439 (rank : 1170)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.051024 (rank : 1159)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	θ > 10 (rank : 719)	NC score	0.051986 (rank : 1121)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	91
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.051142 (rank : 1154)
Query Neighborhood Hits	583	Target Neighborhood Hits	922	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DDR1_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.142529 (rank : 430)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	90
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 722)	NC score	0.142639 (rank : 428)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	91
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.139409 (rank : 435)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	89
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 724)	NC score	0.138057 (rank : 439)
Query Neighborhood Hits	583	Target Neighborhood Hits	813	Shared Neighborhood Hits	90
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK1_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.059845 (rank : 871)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK1_MOUSE
θ value	θ > 10 (rank : 726)	NC score	0.060344 (rank : 857)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK2_HUMAN
θ value	θ > 10 (rank : 727)	NC score	0.067871 (rank : 724)
Query Neighborhood Hits	583	Target Neighborhood Hits	856	Shared Neighborhood Hits	87
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 728)	NC score	0.065409 (rank : 758)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	89
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK3_HUMAN
θ value	θ > 10 (rank : 729)	NC score	0.062372 (rank : 808)
Query Neighborhood Hits	583	Target Neighborhood Hits	859	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.064233 (rank : 774)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

EGFR_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.127488 (rank : 474)
Query Neighborhood Hits	583	Target Neighborhood Hits	939	Shared Neighborhood Hits	93
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.128018 (rank : 472)
Query Neighborhood Hits	583	Target Neighborhood Hits	927	Shared Neighborhood Hits	95
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EMB_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.143683 (rank : 426)
Query Neighborhood Hits	583	Target Neighborhood Hits	54	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

ERBB2_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.130377 (rank : 466)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	113
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 735)	NC score	0.129593 (rank : 468)
Query Neighborhood Hits	583	Target Neighborhood Hits	918	Shared Neighborhood Hits	99
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.130228 (rank : 467)
Query Neighborhood Hits	583	Target Neighborhood Hits	918	Shared Neighborhood Hits	90
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 737)	NC score	0.129062 (rank : 470)
Query Neighborhood Hits	583	Target Neighborhood Hits	898	Shared Neighborhood Hits	88
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 738)	NC score	0.129008 (rank : 471)
Query Neighborhood Hits	583	Target Neighborhood Hits	910	Shared Neighborhood Hits	98
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERN1_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.052238 (rank : 1115)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	85
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN1_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.051247 (rank : 1149)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	84
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FAK1_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.132022 (rank : 461)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	90
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.131726 (rank : 463)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	90
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.132381 (rank : 460)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 744)	NC score	0.131759 (rank : 462)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FCERA_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.200202 (rank : 380)
Query Neighborhood Hits	583	Target Neighborhood Hits	150	Shared Neighborhood Hits	117
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCERA_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.062224 (rank : 810)
Query Neighborhood Hits	583	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FCG2A_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.103001 (rank : 571)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	68
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

FCG2B_HUMAN
θ value	θ > 10 (rank : 748)	NC score	0.126604 (rank : 477)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	78
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.126016 (rank : 479)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	79
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FCG3B_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.076431 (rank : 672)
Query Neighborhood Hits	583	Target Neighborhood Hits	67	Shared Neighborhood Hits	51
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

FCGR2_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.061673 (rank : 821)
Query Neighborhood Hits	583	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

FCGR3_MOUSE
θ value	θ > 10 (rank : 752)	NC score	0.050341 (rank : 1173)
Query Neighborhood Hits	583	Target Neighborhood Hits	98	Shared Neighborhood Hits	44
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

FCRLA_HUMAN
θ value	θ > 10 (rank : 753)	NC score	0.111362 (rank : 541)
Query Neighborhood Hits	583	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FCRLA_MOUSE
θ value	θ > 10 (rank : 754)	NC score	0.107960 (rank : 551)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	62
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FER_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.121787 (rank : 489)
Query Neighborhood Hits	583	Target Neighborhood Hits	1278	Shared Neighborhood Hits	91
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.124949 (rank : 481)
Query Neighborhood Hits	583	Target Neighborhood Hits	978	Shared Neighborhood Hits	88
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 757)	NC score	0.124777 (rank : 482)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGR_HUMAN
θ value	θ > 10 (rank : 758)	NC score	0.116135 (rank : 521)
Query Neighborhood Hits	583	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.115960 (rank : 523)
Query Neighborhood Hits	583	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FLRT1_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.070220 (rank : 706)
Query Neighborhood Hits	583	Target Neighborhood Hits	286	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

FLRT2_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.064711 (rank : 766)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	48
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

FLRT3_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.071795 (rank : 693)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

FLT3_HUMAN
θ value	θ > 10 (rank : 763)	NC score	0.179263 (rank : 398)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	132
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.198907 (rank : 381)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	140
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FPRP_MOUSE
θ value	θ > 10 (rank : 765)	NC score	0.123267 (rank : 486)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

FRK_HUMAN
θ value	θ > 10 (rank : 766)	NC score	0.118121 (rank : 510)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.112526 (rank : 538)
Query Neighborhood Hits	583	Target Neighborhood Hits	1078	Shared Neighborhood Hits	88
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 768)	NC score	0.113389 (rank : 535)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	88
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GP124_HUMAN
θ value	θ > 10 (rank : 769)	NC score	0.061283 (rank : 833)
Query Neighborhood Hits	583	Target Neighborhood Hits	304	Shared Neighborhood Hits	46
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP124_MOUSE
θ value	θ > 10 (rank : 770)	NC score	0.061288 (rank : 832)
Query Neighborhood Hits	583	Target Neighborhood Hits	423	Shared Neighborhood Hits	57
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP125_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.079291 (rank : 665)
Query Neighborhood Hits	583	Target Neighborhood Hits	327	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GP125_MOUSE
θ value	θ > 10 (rank : 772)	NC score	0.081033 (rank : 657)
Query Neighborhood Hits	583	Target Neighborhood Hits	329	Shared Neighborhood Hits	66
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GP1BA_HUMAN
θ value	θ > 10 (rank : 773)	NC score	0.058706 (rank : 904)
Query Neighborhood Hits	583	Target Neighborhood Hits	407	Shared Neighborhood Hits	53
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

GP1BB_MOUSE
θ value	θ > 10 (rank : 774)	NC score	0.052958 (rank : 1101)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

GPIX_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.056475 (rank : 975)
Query Neighborhood Hits	583	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

GPV_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.058487 (rank : 909)
Query Neighborhood Hits	583	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GPV_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.060114 (rank : 864)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

GRK4_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.054647 (rank : 1043)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	89
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 779)	NC score	0.056175 (rank : 983)
Query Neighborhood Hits	583	Target Neighborhood Hits	808	Shared Neighborhood Hits	87
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.051755 (rank : 1128)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.051796 (rank : 1127)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.053349 (rank : 1090)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	87
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.053201 (rank : 1093)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	87
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GUC2C_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.103327 (rank : 570)
Query Neighborhood Hits	583	Target Neighborhood Hits	624	Shared Neighborhood Hits	79
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 785)	NC score	0.081744 (rank : 651)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	86
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.087282 (rank : 632)
Query Neighborhood Hits	583	Target Neighborhood Hits	692	Shared Neighborhood Hits	84
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.101203 (rank : 576)
Query Neighborhood Hits	583	Target Neighborhood Hits	740	Shared Neighborhood Hits	86
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.081261 (rank : 656)
Query Neighborhood Hits	583	Target Neighborhood Hits	644	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCK_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.118531 (rank : 503)
Query Neighborhood Hits	583	Target Neighborhood Hits	1035	Shared Neighborhood Hits	89
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.118762 (rank : 501)
Query Neighborhood Hits	583	Target Neighborhood Hits	1029	Shared Neighborhood Hits	88
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HHLA2_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.203740 (rank : 376)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HUNK_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.055545 (rank : 1004)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	90
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 793)	NC score	0.055157 (rank : 1024)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

I11RA_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.123657 (rank : 484)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

I11RB_MOUSE
θ value	θ > 10 (rank : 795)	NC score	0.134175 (rank : 451)
Query Neighborhood Hits	583	Target Neighborhood Hits	101	Shared Neighborhood Hits	66
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

I12R1_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.139852 (rank : 434)
Query Neighborhood Hits	583	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

I18RA_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.099349 (rank : 580)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	66
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

I18RA_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.095571 (rank : 602)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

I27RA_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.137356 (rank : 441)
Query Neighborhood Hits	583	Target Neighborhood Hits	60	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

I27RA_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.080032 (rank : 663)
Query Neighborhood Hits	583	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

ICAM1_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.147942 (rank : 421)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ICAM1_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.167551 (rank : 405)
Query Neighborhood Hits	583	Target Neighborhood Hits	99	Shared Neighborhood Hits	86
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ICAM3_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.156309 (rank : 411)
Query Neighborhood Hits	583	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

ICK_HUMAN
θ value	θ > 10 (rank : 804)	NC score	0.064316 (rank : 773)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 805)	NC score	0.064000 (rank : 780)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ICOSL_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.091176 (rank : 618)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

IGSF8_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.081545 (rank : 655)
Query Neighborhood Hits	583	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

IKKA_HUMAN
θ value	θ > 10 (rank : 808)	NC score	0.074517 (rank : 678)
Query Neighborhood Hits	583	Target Neighborhood Hits	863	Shared Neighborhood Hits	88
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 809)	NC score	0.074315 (rank : 680)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 810)	NC score	0.067695 (rank : 729)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 811)	NC score	0.067463 (rank : 731)
Query Neighborhood Hits	583	Target Neighborhood Hits	984	Shared Neighborhood Hits	88
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 812)	NC score	0.057864 (rank : 931)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.057814 (rank : 933)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IL18R_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.062779 (rank : 803)
Query Neighborhood Hits	583	Target Neighborhood Hits	81	Shared Neighborhood Hits	40
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

IL18R_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.072136 (rank : 691)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

IL6RA_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.097151 (rank : 591)
Query Neighborhood Hits	583	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 817)	NC score	0.093701 (rank : 610)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	90
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.091650 (rank : 616)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	90
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 819)	NC score	0.094211 (rank : 606)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	90
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL2_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.177310 (rank : 399)
Query Neighborhood Hits	583	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

IRAK1_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.077608 (rank : 670)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	93
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.077490 (rank : 671)
Query Neighborhood Hits	583	Target Neighborhood Hits	784	Shared Neighborhood Hits	95
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.061031 (rank : 840)
Query Neighborhood Hits	583	Target Neighborhood Hits	714	Shared Neighborhood Hits	76
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.080619 (rank : 659)
Query Neighborhood Hits	583	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 825)	NC score	0.086869 (rank : 634)
Query Neighborhood Hits	583	Target Neighborhood Hits	628	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 826)	NC score	0.086991 (rank : 633)
Query Neighborhood Hits	583	Target Neighborhood Hits	816	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.085162 (rank : 639)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	89
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.117917 (rank : 513)
Query Neighborhood Hits	583	Target Neighborhood Hits	1016	Shared Neighborhood Hits	88
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.118539 (rank : 502)
Query Neighborhood Hits	583	Target Neighborhood Hits	985	Shared Neighborhood Hits	88
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.116159 (rank : 520)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 831)	NC score	0.116028 (rank : 522)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.113833 (rank : 532)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 833)	NC score	0.113677 (rank : 533)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.115219 (rank : 529)
Query Neighborhood Hits	583	Target Neighborhood Hits	827	Shared Neighborhood Hits	87
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.111414 (rank : 540)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	86
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

K0999_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.056836 (rank : 960)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.056925 (rank : 959)
Query Neighborhood Hits	583	Target Neighborhood Hits	931	Shared Neighborhood Hits	95
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCG_HUMAN
θ value	θ > 10 (rank : 838)	NC score	0.051053 (rank : 1157)
Query Neighborhood Hits	583	Target Neighborhood Hits	845	Shared Neighborhood Hits	88
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KCC1A_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.058280 (rank : 915)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.058189 (rank : 918)
Query Neighborhood Hits	583	Target Neighborhood Hits	845	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.055462 (rank : 1010)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.055701 (rank : 997)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.054355 (rank : 1050)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.054533 (rank : 1047)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.054757 (rank : 1039)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	89
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.054696 (rank : 1041)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.050532 (rank : 1167)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2G_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.051276 (rank : 1148)
Query Neighborhood Hits	583	Target Neighborhood Hits	841	Shared Neighborhood Hits	87
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	θ > 10 (rank : 849)	NC score	0.051279 (rank : 1147)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KGP1A_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.051309 (rank : 1146)
Query Neighborhood Hits	583	Target Neighborhood Hits	901	Shared Neighborhood Hits	90
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.051199 (rank : 1151)
Query Neighborhood Hits	583	Target Neighborhood Hits	921	Shared Neighborhood Hits	89
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.051196 (rank : 1152)
Query Neighborhood Hits	583	Target Neighborhood Hits	922	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KKCC1_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.055383 (rank : 1013)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.055230 (rank : 1020)
Query Neighborhood Hits	583	Target Neighborhood Hits	866	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.058914 (rank : 894)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	90
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.058884 (rank : 895)
Query Neighborhood Hits	583	Target Neighborhood Hits	855	Shared Neighborhood Hits	89
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCA_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.054201 (rank : 1052)
Query Neighborhood Hits	583	Target Neighborhood Hits	1070	Shared Neighborhood Hits	92
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.055618 (rank : 1000)
Query Neighborhood Hits	583	Target Neighborhood Hits	1067	Shared Neighborhood Hits	92
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCB_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.054777 (rank : 1037)
Query Neighborhood Hits	583	Target Neighborhood Hits	1121	Shared Neighborhood Hits	92
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.055045 (rank : 1028)
Query Neighborhood Hits	583	Target Neighborhood Hits	1117	Shared Neighborhood Hits	92
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD2_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.051546 (rank : 1133)
Query Neighborhood Hits	583	Target Neighborhood Hits	910	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.058407 (rank : 912)
Query Neighborhood Hits	583	Target Neighborhood Hits	900	Shared Neighborhood Hits	89
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.057661 (rank : 937)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	89
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.057220 (rank : 947)
Query Neighborhood Hits	583	Target Neighborhood Hits	897	Shared Neighborhood Hits	90
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	θ > 10 (rank : 865)	NC score	0.056572 (rank : 970)
Query Neighborhood Hits	583	Target Neighborhood Hits	895	Shared Neighborhood Hits	90
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.054899 (rank : 1032)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	89
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.055035 (rank : 1029)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 868)	NC score	0.058743 (rank : 901)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.063110 (rank : 795)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.060225 (rank : 860)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.063224 (rank : 792)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	88
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.062690 (rank : 804)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.064129 (rank : 776)
Query Neighborhood Hits	583	Target Neighborhood Hits	859	Shared Neighborhood Hits	88
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.064074 (rank : 778)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.061784 (rank : 820)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.052881 (rank : 1103)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 877)	NC score	0.052936 (rank : 1102)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 878)	NC score	0.050108 (rank : 1177)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KSR1_HUMAN
θ value	θ > 10 (rank : 879)	NC score	0.090501 (rank : 619)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 880)	NC score	0.090296 (rank : 621)
Query Neighborhood Hits	583	Target Neighborhood Hits	870	Shared Neighborhood Hits	92
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 881)	NC score	0.080805 (rank : 658)
Query Neighborhood Hits	583	Target Neighborhood Hits	920	Shared Neighborhood Hits	98
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.126963 (rank : 476)
Query Neighborhood Hits	583	Target Neighborhood Hits	901	Shared Neighborhood Hits	87
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.127295 (rank : 475)
Query Neighborhood Hits	583	Target Neighborhood Hits	944	Shared Neighborhood Hits	95
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAMA5_HUMAN
θ value	θ > 10 (rank : 884)	NC score	0.053823 (rank : 1073)
Query Neighborhood Hits	583	Target Neighborhood Hits	976	Shared Neighborhood Hits	82
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMA5_MOUSE
θ value	θ > 10 (rank : 885)	NC score	0.053444 (rank : 1088)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	68
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LCK_HUMAN
θ value	θ > 10 (rank : 886)	NC score	0.118216 (rank : 507)
Query Neighborhood Hits	583	Target Neighborhood Hits	987	Shared Neighborhood Hits	91
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 887)	NC score	0.117646 (rank : 514)
Query Neighborhood Hits	583	Target Neighborhood Hits	981	Shared Neighborhood Hits	88
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LGI1_HUMAN
θ value	θ > 10 (rank : 888)	NC score	0.053729 (rank : 1075)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

LGI1_MOUSE
θ value	θ > 10 (rank : 889)	NC score	0.054032 (rank : 1063)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

LGI2_HUMAN
θ value	θ > 10 (rank : 890)	NC score	0.053950 (rank : 1067)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

LGI3_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.054168 (rank : 1056)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

LGI3_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.052975 (rank : 1099)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

LGI4_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.056542 (rank : 973)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGI4_MOUSE
θ value	θ > 10 (rank : 894)	NC score	0.053527 (rank : 1084)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

LGR4_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.051510 (rank : 1135)
Query Neighborhood Hits	583	Target Neighborhood Hits	481	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

LGR5_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.052493 (rank : 1108)
Query Neighborhood Hits	583	Target Neighborhood Hits	452	Shared Neighborhood Hits	37
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

LGR5_MOUSE
θ value	θ > 10 (rank : 897)	NC score	0.051541 (rank : 1134)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

LGR6_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.050652 (rank : 1164)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

LIMK1_HUMAN
θ value	θ > 10 (rank : 899)	NC score	0.088556 (rank : 627)
Query Neighborhood Hits	583	Target Neighborhood Hits	1005	Shared Neighborhood Hits	91
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 900)	NC score	0.088361 (rank : 628)
Query Neighborhood Hits	583	Target Neighborhood Hits	1008	Shared Neighborhood Hits	92
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 901)	NC score	0.087859 (rank : 629)
Query Neighborhood Hits	583	Target Neighborhood Hits	986	Shared Neighborhood Hits	90
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 902)	NC score	0.087756 (rank : 630)
Query Neighborhood Hits	583	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LR37A_HUMAN
θ value	θ > 10 (rank : 903)	NC score	0.060710 (rank : 853)
Query Neighborhood Hits	583	Target Neighborhood Hits	720	Shared Neighborhood Hits	86
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LR37B_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.057663 (rank : 936)
Query Neighborhood Hits	583	Target Neighborhood Hits	392	Shared Neighborhood Hits	55
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

LRC15_HUMAN
θ value	θ > 10 (rank : 905)	NC score	0.060259 (rank : 859)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

LRC15_MOUSE
θ value	θ > 10 (rank : 906)	NC score	0.062926 (rank : 798)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	38
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

LRC17_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.051063 (rank : 1156)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

LRC17_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.054894 (rank : 1033)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

LRC19_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.051980 (rank : 1122)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC19_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.054488 (rank : 1048)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC32_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.055334 (rank : 1017)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	37
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

LRC33_HUMAN
θ value	θ > 10 (rank : 912)	NC score	0.053037 (rank : 1098)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC33_MOUSE
θ value	θ > 10 (rank : 913)	NC score	0.050471 (rank : 1169)
Query Neighborhood Hits	583	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LRC52_HUMAN
θ value	θ > 10 (rank : 914)	NC score	0.053663 (rank : 1079)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC52_MOUSE
θ value	θ > 10 (rank : 915)	NC score	0.054241 (rank : 1051)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	37
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

LRC55_HUMAN
θ value	θ > 10 (rank : 916)	NC score	0.054367 (rank : 1049)
Query Neighborhood Hits	583	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRC55_MOUSE
θ value	θ > 10 (rank : 917)	NC score	0.054765 (rank : 1038)
Query Neighborhood Hits	583	Target Neighborhood Hits	254	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

LRRC3_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.050564 (rank : 1166)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRC3_MOUSE
θ value	θ > 10 (rank : 919)	NC score	0.055147 (rank : 1025)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

LRRK1_HUMAN
θ value	θ > 10 (rank : 920)	NC score	0.098457 (rank : 588)
Query Neighborhood Hits	583	Target Neighborhood Hits	1237	Shared Neighborhood Hits	123
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 921)	NC score	0.100789 (rank : 577)
Query Neighborhood Hits	583	Target Neighborhood Hits	1267	Shared Neighborhood Hits	124
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 922)	NC score	0.085983 (rank : 637)
Query Neighborhood Hits	583	Target Neighborhood Hits	1382	Shared Neighborhood Hits	117
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 923)	NC score	0.084154 (rank : 642)
Query Neighborhood Hits	583	Target Neighborhood Hits	1359	Shared Neighborhood Hits	119
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LRTM1_HUMAN
θ value	θ > 10 (rank : 924)	NC score	0.056795 (rank : 962)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM1_MOUSE
θ value	θ > 10 (rank : 925)	NC score	0.058062 (rank : 921)
Query Neighborhood Hits	583	Target Neighborhood Hits	264	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

LRTM2_HUMAN
θ value	θ > 10 (rank : 926)	NC score	0.056716 (rank : 965)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

LRTM2_MOUSE
θ value	θ > 10 (rank : 927)	NC score	0.056721 (rank : 964)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

LRTM3_HUMAN
θ value	θ > 10 (rank : 928)	NC score	0.055173 (rank : 1022)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	38
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM3_MOUSE
θ value	θ > 10 (rank : 929)	NC score	0.054567 (rank : 1046)
Query Neighborhood Hits	583	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

LRTM4_HUMAN
θ value	θ > 10 (rank : 930)	NC score	0.057050 (rank : 953)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	40
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LRTM4_MOUSE
θ value	θ > 10 (rank : 931)	NC score	0.057463 (rank : 942)
Query Neighborhood Hits	583	Target Neighborhood Hits	284	Shared Neighborhood Hits	39
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

LTK_HUMAN
θ value	θ > 10 (rank : 932)	NC score	0.151064 (rank : 417)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	91
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 933)	NC score	0.150473 (rank : 418)
Query Neighborhood Hits	583	Target Neighborhood Hits	770	Shared Neighborhood Hits	89
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LY9_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.072720 (rank : 685)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

LYN_HUMAN
θ value	θ > 10 (rank : 935)	NC score	0.116267 (rank : 519)
Query Neighborhood Hits	583	Target Neighborhood Hits	1022	Shared Neighborhood Hits	88
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 936)	NC score	0.116416 (rank : 518)
Query Neighborhood Hits	583	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 937)	NC score	0.098574 (rank : 587)
Query Neighborhood Hits	583	Target Neighborhood Hits	1071	Shared Neighborhood Hits	95
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.098172 (rank : 589)
Query Neighborhood Hits	583	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 939)	NC score	0.098903 (rank : 583)
Query Neighborhood Hits	583	Target Neighborhood Hits	940	Shared Neighborhood Hits	94
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 940)	NC score	0.098997 (rank : 582)
Query Neighborhood Hits	583	Target Neighborhood Hits	957	Shared Neighborhood Hits	95
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 941)	NC score	0.096555 (rank : 594)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	89
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K15_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.061868 (rank : 816)
Query Neighborhood Hits	583	Target Neighborhood Hits	914	Shared Neighborhood Hits	88
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.060882 (rank : 850)
Query Neighborhood Hits	583	Target Neighborhood Hits	952	Shared Neighborhood Hits	93
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 944)	NC score	0.053473 (rank : 1087)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 945)	NC score	0.051328 (rank : 1145)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 946)	NC score	0.057373 (rank : 944)
Query Neighborhood Hits	583	Target Neighborhood Hits	885	Shared Neighborhood Hits	90
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 947)	NC score	0.057146 (rank : 950)
Query Neighborhood Hits	583	Target Neighborhood Hits	876	Shared Neighborhood Hits	88
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.055106 (rank : 1026)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 949)	NC score	0.054057 (rank : 1060)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	89
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 950)	NC score	0.061175 (rank : 836)
Query Neighborhood Hits	583	Target Neighborhood Hits	868	Shared Neighborhood Hits	88
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 951)	NC score	0.061394 (rank : 825)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	89
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 952)	NC score	0.058805 (rank : 898)
Query Neighborhood Hits	583	Target Neighborhood Hits	889	Shared Neighborhood Hits	95
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K7_HUMAN
θ value	θ > 10 (rank : 953)	NC score	0.093859 (rank : 609)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	90
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 954)	NC score	0.093894 (rank : 608)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	90
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_HUMAN
θ value	θ > 10 (rank : 955)	NC score	0.056047 (rank : 989)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	81
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_MOUSE
θ value	θ > 10 (rank : 956)	NC score	0.053919 (rank : 1068)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	81
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K9_HUMAN
θ value	θ > 10 (rank : 957)	NC score	0.098618 (rank : 585)
Query Neighborhood Hits	583	Target Neighborhood Hits	1123	Shared Neighborhood Hits	106
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.102050 (rank : 574)
Query Neighborhood Hits	583	Target Neighborhood Hits	1087	Shared Neighborhood Hits	93
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

M4K1_HUMAN
θ value	θ > 10 (rank : 959)	NC score	0.057944 (rank : 927)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	92
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 960)	NC score	0.057606 (rank : 939)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 961)	NC score	0.052216 (rank : 1116)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	89
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 962)	NC score	0.052845 (rank : 1104)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	87
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 963)	NC score	0.054577 (rank : 1045)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	89
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K4_HUMAN
θ value	θ > 10 (rank : 964)	NC score	0.053841 (rank : 1072)
Query Neighborhood Hits	583	Target Neighborhood Hits	1589	Shared Neighborhood Hits	93
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	θ > 10 (rank : 965)	NC score	0.057838 (rank : 932)
Query Neighborhood Hits	583	Target Neighborhood Hits	1560	Shared Neighborhood Hits	93
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MAK_HUMAN
θ value	θ > 10 (rank : 966)	NC score	0.064951 (rank : 763)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	87
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	θ > 10 (rank : 967)	NC score	0.065438 (rank : 757)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	91
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAMC2_HUMAN
θ value	θ > 10 (rank : 968)	NC score	0.061790 (rank : 819)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAMC2_MOUSE
θ value	θ > 10 (rank : 969)	NC score	0.062216 (rank : 811)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

MAPK2_HUMAN
θ value	θ > 10 (rank : 970)	NC score	0.051491 (rank : 1136)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	91
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 971)	NC score	0.051081 (rank : 1155)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_MOUSE
θ value	θ > 10 (rank : 972)	NC score	0.052075 (rank : 1118)
Query Neighborhood Hits	583	Target Neighborhood Hits	811	Shared Neighborhood Hits	86
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MARK1_HUMAN
θ value	θ > 10 (rank : 973)	NC score	0.059216 (rank : 888)
Query Neighborhood Hits	583	Target Neighborhood Hits	887	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 974)	NC score	0.058708 (rank : 903)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 975)	NC score	0.060074 (rank : 867)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	111
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 976)	NC score	0.058215 (rank : 917)
Query Neighborhood Hits	583	Target Neighborhood Hits	1018	Shared Neighborhood Hits	103
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 977)	NC score	0.059522 (rank : 877)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	95
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 978)	NC score	0.058346 (rank : 914)
Query Neighborhood Hits	583	Target Neighborhood Hits	919	Shared Neighborhood Hits	91
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 979)	NC score	0.057058 (rank : 952)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	91
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 980)	NC score	0.056994 (rank : 957)
Query Neighborhood Hits	583	Target Neighborhood Hits	898	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MATK_HUMAN
θ value	θ > 10 (rank : 981)	NC score	0.123323 (rank : 485)
Query Neighborhood Hits	583	Target Neighborhood Hits	954	Shared Neighborhood Hits	88
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 982)	NC score	0.122562 (rank : 488)
Query Neighborhood Hits	583	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MEGF9_HUMAN
θ value	θ > 10 (rank : 983)	NC score	0.054190 (rank : 1053)
Query Neighborhood Hits	583	Target Neighborhood Hits	557	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MEGF9_MOUSE
θ value	θ > 10 (rank : 984)	NC score	0.054792 (rank : 1036)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MELK_HUMAN
θ value	θ > 10 (rank : 985)	NC score	0.055773 (rank : 995)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	87
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 986)	NC score	0.056593 (rank : 969)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MET_HUMAN
θ value	θ > 10 (rank : 987)	NC score	0.133178 (rank : 456)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 988)	NC score	0.133292 (rank : 455)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MINK1_HUMAN
θ value	θ > 10 (rank : 989)	NC score	0.059238 (rank : 886)
Query Neighborhood Hits	583	Target Neighborhood Hits	1477	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	θ > 10 (rank : 990)	NC score	0.058628 (rank : 906)
Query Neighborhood Hits	583	Target Neighborhood Hits	1451	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK01_HUMAN
θ value	θ > 10 (rank : 991)	NC score	0.056106 (rank : 986)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	87
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	θ > 10 (rank : 992)	NC score	0.056174 (rank : 984)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	87
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	θ > 10 (rank : 993)	NC score	0.055819 (rank : 994)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	87
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	θ > 10 (rank : 994)	NC score	0.055606 (rank : 1002)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK04_HUMAN
θ value	θ > 10 (rank : 995)	NC score	0.056331 (rank : 978)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
θ value	θ > 10 (rank : 996)	NC score	0.055316 (rank : 1018)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	81
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK06_HUMAN
θ value	θ > 10 (rank : 997)	NC score	0.051153 (rank : 1153)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	80
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	θ > 10 (rank : 998)	NC score	0.051229 (rank : 1150)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	80
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK07_HUMAN
θ value	θ > 10 (rank : 999)	NC score	0.059540 (rank : 876)
Query Neighborhood Hits	583	Target Neighborhood Hits	1087	Shared Neighborhood Hits	110
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	θ > 10 (rank : 1000)	NC score	0.060931 (rank : 845)
Query Neighborhood Hits	583	Target Neighborhood Hits	1054	Shared Neighborhood Hits	108
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK10_HUMAN
θ value	θ > 10 (rank : 1001)	NC score	0.050372 (rank : 1172)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	90
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK11_HUMAN
θ value	θ > 10 (rank : 1002)	NC score	0.053668 (rank : 1078)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	86
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MK11_MOUSE
θ value	θ > 10 (rank : 1003)	NC score	0.051433 (rank : 1139)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	θ > 10 (rank : 1004)	NC score	0.053806 (rank : 1074)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	87
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_MOUSE
θ value	θ > 10 (rank : 1005)	NC score	0.053115 (rank : 1094)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK13_HUMAN
θ value	θ > 10 (rank : 1006)	NC score	0.053581 (rank : 1082)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	87
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	θ > 10 (rank : 1007)	NC score	0.053569 (rank : 1083)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	θ > 10 (rank : 1008)	NC score	0.053326 (rank : 1091)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	θ > 10 (rank : 1009)	NC score	0.052486 (rank : 1109)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK15_HUMAN
θ value	θ > 10 (rank : 1010)	NC score	0.054641 (rank : 1044)
Query Neighborhood Hits	583	Target Neighborhood Hits	1038	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MLKL_HUMAN
θ value	θ > 10 (rank : 1011)	NC score	0.102036 (rank : 575)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 1012)	NC score	0.095654 (rank : 600)
Query Neighborhood Hits	583	Target Neighborhood Hits	707	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 1013)	NC score	0.099539 (rank : 579)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 1014)	NC score	0.099729 (rank : 578)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOK_HUMAN
θ value	θ > 10 (rank : 1015)	NC score	0.053687 (rank : 1076)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
θ value	θ > 10 (rank : 1016)	NC score	0.054092 (rank : 1058)
Query Neighborhood Hits	583	Target Neighborhood Hits	796	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOS_HUMAN
θ value	θ > 10 (rank : 1017)	NC score	0.093109 (rank : 611)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	88
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 1018)	NC score	0.088643 (rank : 626)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	89
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K1_HUMAN
θ value	θ > 10 (rank : 1019)	NC score	0.056292 (rank : 979)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 1020)	NC score	0.056229 (rank : 981)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 1021)	NC score	0.056558 (rank : 971)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 1022)	NC score	0.055496 (rank : 1006)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_HUMAN
θ value	θ > 10 (rank : 1023)	NC score	0.056688 (rank : 966)
Query Neighborhood Hits	583	Target Neighborhood Hits	825	Shared Neighborhood Hits	88
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	θ > 10 (rank : 1024)	NC score	0.055686 (rank : 998)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
θ value	θ > 10 (rank : 1025)	NC score	0.057241 (rank : 946)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	θ > 10 (rank : 1026)	NC score	0.057328 (rank : 945)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K5_HUMAN
θ value	θ > 10 (rank : 1027)	NC score	0.067742 (rank : 726)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	89
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 1028)	NC score	0.068596 (rank : 718)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.057212 (rank : 948)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_MOUSE
θ value	θ > 10 (rank : 1030)	NC score	0.056490 (rank : 974)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
θ value	θ > 10 (rank : 1031)	NC score	0.057207 (rank : 949)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	87
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 1032)	NC score	0.071367 (rank : 695)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 1033)	NC score	0.071254 (rank : 698)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYLK2_HUMAN
θ value	θ > 10 (rank : 1034)	NC score	0.071317 (rank : 696)
Query Neighborhood Hits	583	Target Neighborhood Hits	920	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NAGPA_HUMAN
θ value	θ > 10 (rank : 1035)	NC score	0.051397 (rank : 1142)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NAGPA_MOUSE
θ value	θ > 10 (rank : 1036)	NC score	0.053844 (rank : 1071)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

NEK11_HUMAN
θ value	θ > 10 (rank : 1037)	NC score	0.072631 (rank : 686)
Query Neighborhood Hits	583	Target Neighborhood Hits	1043	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 1038)	NC score	0.073897 (rank : 683)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 1039)	NC score	0.062781 (rank : 802)
Query Neighborhood Hits	583	Target Neighborhood Hits	1129	Shared Neighborhood Hits	90
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 1040)	NC score	0.062989 (rank : 797)
Query Neighborhood Hits	583	Target Neighborhood Hits	1311	Shared Neighborhood Hits	96
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 1041)	NC score	0.061077 (rank : 838)
Query Neighborhood Hits	583	Target Neighborhood Hits	908	Shared Neighborhood Hits	88
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 1042)	NC score	0.057907 (rank : 929)
Query Neighborhood Hits	583	Target Neighborhood Hits	876	Shared Neighborhood Hits	89
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 1043)	NC score	0.064172 (rank : 775)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	88
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 1044)	NC score	0.063756 (rank : 782)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 1045)	NC score	0.068957 (rank : 715)
Query Neighborhood Hits	583	Target Neighborhood Hits	883	Shared Neighborhood Hits	89
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 1046)	NC score	0.068615 (rank : 717)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 1047)	NC score	0.070355 (rank : 705)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 1048)	NC score	0.070168 (rank : 707)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 1049)	NC score	0.071877 (rank : 692)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 1050)	NC score	0.071788 (rank : 694)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK8_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.059882 (rank : 870)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	88
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.059907 (rank : 869)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	89
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 1053)	NC score	0.062447 (rank : 807)
Query Neighborhood Hits	583	Target Neighborhood Hits	900	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 1054)	NC score	0.061361 (rank : 828)
Query Neighborhood Hits	583	Target Neighborhood Hits	890	Shared Neighborhood Hits	89
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NIM1_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.058390 (rank : 913)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 1056)	NC score	0.056101 (rank : 987)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NLK_HUMAN
θ value	θ > 10 (rank : 1057)	NC score	0.057979 (rank : 924)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	θ > 10 (rank : 1058)	NC score	0.057971 (rank : 925)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	89
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.058569 (rank : 907)
Query Neighborhood Hits	583	Target Neighborhood Hits	931	Shared Neighborhood Hits	90
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.055608 (rank : 1001)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUAK1_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.061412 (rank : 824)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 1062)	NC score	0.061048 (rank : 839)
Query Neighborhood Hits	583	Target Neighborhood Hits	881	Shared Neighborhood Hits	89
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 1063)	NC score	0.063640 (rank : 786)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 1064)	NC score	0.061852 (rank : 817)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NYX_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.064594 (rank : 769)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

NYX_MOUSE
θ value	θ > 10 (rank : 1066)	NC score	0.065687 (rank : 753)
Query Neighborhood Hits	583	Target Neighborhood Hits	241	Shared Neighborhood Hits	37
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

OXSR1_HUMAN
θ value	θ > 10 (rank : 1067)	NC score	0.064110 (rank : 777)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	90
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 1068)	NC score	0.063667 (rank : 785)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 1069)	NC score	0.058013 (rank : 923)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	92
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 1070)	NC score	0.057781 (rank : 934)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	93
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 1071)	NC score	0.057879 (rank : 930)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	89
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 1072)	NC score	0.057926 (rank : 928)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 1073)	NC score	0.056403 (rank : 977)
Query Neighborhood Hits	583	Target Neighborhood Hits	887	Shared Neighborhood Hits	89
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 1074)	NC score	0.056444 (rank : 976)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 1075)	NC score	0.058800 (rank : 899)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	100
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 1076)	NC score	0.058816 (rank : 897)
Query Neighborhood Hits	583	Target Neighborhood Hits	1098	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 1077)	NC score	0.063014 (rank : 796)
Query Neighborhood Hits	583	Target Neighborhood Hits	915	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 1078)	NC score	0.060989 (rank : 843)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 1079)	NC score	0.060549 (rank : 855)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PASK_HUMAN
θ value	θ > 10 (rank : 1080)	NC score	0.051632 (rank : 1130)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	88
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 1081)	NC score	0.051571 (rank : 1132)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCTK1_HUMAN
θ value	θ > 10 (rank : 1082)	NC score	0.056271 (rank : 980)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	θ > 10 (rank : 1083)	NC score	0.056656 (rank : 967)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_HUMAN
θ value	θ > 10 (rank : 1084)	NC score	0.056555 (rank : 972)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	86
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	θ > 10 (rank : 1085)	NC score	0.056611 (rank : 968)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	θ > 10 (rank : 1086)	NC score	0.054716 (rank : 1040)
Query Neighborhood Hits	583	Target Neighborhood Hits	827	Shared Neighborhood Hits	85
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PCTK3_MOUSE
θ value	θ > 10 (rank : 1087)	NC score	0.055358 (rank : 1014)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	86
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PDK1L_HUMAN
θ value	θ > 10 (rank : 1088)	NC score	0.053583 (rank : 1081)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 1089)	NC score	0.053858 (rank : 1070)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	87
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDL2_HUMAN
θ value	θ > 10 (rank : 1090)	NC score	0.185441 (rank : 393)
Query Neighborhood Hits	583	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDPK1_HUMAN
θ value	θ > 10 (rank : 1091)	NC score	0.056804 (rank : 961)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 1092)	NC score	0.057039 (rank : 955)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PECA1_MOUSE
θ value	θ > 10 (rank : 1093)	NC score	0.223576 (rank : 361)
Query Neighborhood Hits	583	Target Neighborhood Hits	126	Shared Neighborhood Hits	104
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

PFTK1_HUMAN
θ value	θ > 10 (rank : 1094)	NC score	0.055580 (rank : 1003)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	88
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	θ > 10 (rank : 1095)	NC score	0.055468 (rank : 1009)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PGS1_HUMAN
θ value	θ > 10 (rank : 1096)	NC score	0.052974 (rank : 1100)
Query Neighborhood Hits	583	Target Neighborhood Hits	261	Shared Neighborhood Hits	38
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS1_MOUSE
θ value	θ > 10 (rank : 1097)	NC score	0.053062 (rank : 1095)
Query Neighborhood Hits	583	Target Neighborhood Hits	265	Shared Neighborhood Hits	38
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

PGS2_HUMAN
θ value	θ > 10 (rank : 1098)	NC score	0.051048 (rank : 1158)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	35
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PGS2_MOUSE
θ value	θ > 10 (rank : 1099)	NC score	0.052427 (rank : 1110)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

PINK1_HUMAN
θ value	θ > 10 (rank : 1100)	NC score	0.055670 (rank : 999)
Query Neighborhood Hits	583	Target Neighborhood Hits	741	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 1101)	NC score	0.059411 (rank : 880)
Query Neighborhood Hits	583	Target Neighborhood Hits	726	Shared Neighborhood Hits	80
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKD1_HUMAN
θ value	θ > 10 (rank : 1102)	NC score	0.060104 (rank : 865)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	47
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PKN1_HUMAN
θ value	θ > 10 (rank : 1103)	NC score	0.062548 (rank : 806)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	89
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 1104)	NC score	0.062787 (rank : 801)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	88
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 1105)	NC score	0.059578 (rank : 874)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	88
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 1106)	NC score	0.059309 (rank : 883)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_MOUSE
θ value	θ > 10 (rank : 1107)	NC score	0.060166 (rank : 862)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	100
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 1108)	NC score	0.060802 (rank : 851)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 1109)	NC score	0.058448 (rank : 911)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 1110)	NC score	0.060897 (rank : 847)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 1111)	NC score	0.060993 (rank : 842)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 1112)	NC score	0.059255 (rank : 885)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 1113)	NC score	0.060310 (rank : 858)
Query Neighborhood Hits	583	Target Neighborhood Hits	863	Shared Neighborhood Hits	89
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 1114)	NC score	0.063200 (rank : 793)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	91
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 1115)	NC score	0.063616 (rank : 787)
Query Neighborhood Hits	583	Target Neighborhood Hits	879	Shared Neighborhood Hits	88
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PP1R7_HUMAN
θ value	θ > 10 (rank : 1116)	NC score	0.051838 (rank : 1124)
Query Neighborhood Hits	583	Target Neighborhood Hits	265	Shared Neighborhood Hits	31
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

PRKX_HUMAN
θ value	θ > 10 (rank : 1117)	NC score	0.052024 (rank : 1120)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 1118)	NC score	0.053629 (rank : 1080)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 1119)	NC score	0.055443 (rank : 1011)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PRLR_HUMAN
θ value	θ > 10 (rank : 1120)	NC score	0.066333 (rank : 749)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	46
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_MOUSE
θ value	θ > 10 (rank : 1121)	NC score	0.066359 (rank : 748)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PTK6_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.115446 (rank : 527)
Query Neighborhood Hits	583	Target Neighborhood Hits	1020	Shared Neighborhood Hits	88
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 1123)	NC score	0.118160 (rank : 509)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	88
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 1124)	NC score	0.096167 (rank : 596)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 1125)	NC score	0.096146 (rank : 597)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN12_HUMAN
θ value	θ > 10 (rank : 1126)	NC score	0.104466 (rank : 568)
Query Neighborhood Hits	583	Target Neighborhood Hits	102	Shared Neighborhood Hits	22
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
θ value	θ > 10 (rank : 1127)	NC score	0.103933 (rank : 569)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

PTN13_HUMAN
θ value	θ > 10 (rank : 1128)	NC score	0.075611 (rank : 674)
Query Neighborhood Hits	583	Target Neighborhood Hits	471	Shared Neighborhood Hits	34
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PTN13_MOUSE
θ value	θ > 10 (rank : 1129)	NC score	0.076408 (rank : 673)
Query Neighborhood Hits	583	Target Neighborhood Hits	426	Shared Neighborhood Hits	31
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN14_HUMAN
θ value	θ > 10 (rank : 1130)	NC score	0.085176 (rank : 638)
Query Neighborhood Hits	583	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

PTN14_MOUSE
θ value	θ > 10 (rank : 1131)	NC score	0.083989 (rank : 644)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN18_HUMAN
θ value	θ > 10 (rank : 1132)	NC score	0.104670 (rank : 567)
Query Neighborhood Hits	583	Target Neighborhood Hits	73	Shared Neighborhood Hits	24
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN18_MOUSE
θ value	θ > 10 (rank : 1133)	NC score	0.106092 (rank : 563)
Query Neighborhood Hits	583	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

PTN1_HUMAN
θ value	θ > 10 (rank : 1134)	NC score	0.106877 (rank : 557)
Query Neighborhood Hits	583	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
θ value	θ > 10 (rank : 1135)	NC score	0.106738 (rank : 558)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN21_HUMAN
θ value	θ > 10 (rank : 1136)	NC score	0.083275 (rank : 647)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	24
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

PTN21_MOUSE
θ value	θ > 10 (rank : 1137)	NC score	0.083878 (rank : 645)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	26
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

PTN22_HUMAN
θ value	θ > 10 (rank : 1138)	NC score	0.106685 (rank : 559)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN22_MOUSE
θ value	θ > 10 (rank : 1139)	NC score	0.104698 (rank : 566)
Query Neighborhood Hits	583	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	θ > 10 (rank : 1140)	NC score	0.091561 (rank : 617)
Query Neighborhood Hits	583	Target Neighborhood Hits	646	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PTN2_HUMAN
θ value	θ > 10 (rank : 1141)	NC score	0.108350 (rank : 550)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	22
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

PTN2_MOUSE
θ value	θ > 10 (rank : 1142)	NC score	0.107572 (rank : 553)
Query Neighborhood Hits	583	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTN3_HUMAN
θ value	θ > 10 (rank : 1143)	NC score	0.082254 (rank : 649)
Query Neighborhood Hits	583	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

PTN4_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.079672 (rank : 664)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	30
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN5_HUMAN
θ value	θ > 10 (rank : 1145)	NC score	0.109173 (rank : 549)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_MOUSE
θ value	θ > 10 (rank : 1146)	NC score	0.109248 (rank : 548)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN6_HUMAN
θ value	θ > 10 (rank : 1147)	NC score	0.098734 (rank : 584)
Query Neighborhood Hits	583	Target Neighborhood Hits	234	Shared Neighborhood Hits	23
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 1148)	NC score	0.098595 (rank : 586)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PTN7_HUMAN
θ value	θ > 10 (rank : 1149)	NC score	0.109678 (rank : 545)
Query Neighborhood Hits	583	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

PTN7_MOUSE
θ value	θ > 10 (rank : 1150)	NC score	0.109753 (rank : 543)
Query Neighborhood Hits	583	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_HUMAN
θ value	θ > 10 (rank : 1151)	NC score	0.109393 (rank : 547)
Query Neighborhood Hits	583	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN9_MOUSE
θ value	θ > 10 (rank : 1152)	NC score	0.109730 (rank : 544)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTPR2_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.106336 (rank : 562)
Query Neighborhood Hits	583	Target Neighborhood Hits	103	Shared Neighborhood Hits	21
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTPR2_MOUSE
θ value	θ > 10 (rank : 1154)	NC score	0.106566 (rank : 560)
Query Neighborhood Hits	583	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRA_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.135455 (rank : 444)
Query Neighborhood Hits	583	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRA_MOUSE
θ value	θ > 10 (rank : 1156)	NC score	0.134643 (rank : 449)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

PTPRE_HUMAN
θ value	θ > 10 (rank : 1157)	NC score	0.135235 (rank : 445)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRE_MOUSE
θ value	θ > 10 (rank : 1158)	NC score	0.135541 (rank : 443)
Query Neighborhood Hits	583	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRN_HUMAN
θ value	θ > 10 (rank : 1159)	NC score	0.106491 (rank : 561)
Query Neighborhood Hits	583	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPRN_MOUSE
θ value	θ > 10 (rank : 1160)	NC score	0.107526 (rank : 554)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRR_HUMAN
θ value	θ > 10 (rank : 1161)	NC score	0.107180 (rank : 555)
Query Neighborhood Hits	583	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
θ value	θ > 10 (rank : 1162)	NC score	0.106984 (rank : 556)
Query Neighborhood Hits	583	Target Neighborhood Hits	84	Shared Neighborhood Hits	22
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTPRZ_HUMAN
θ value	θ > 10 (rank : 1163)	NC score	0.133361 (rank : 454)
Query Neighborhood Hits	583	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PVRL1_MOUSE
θ value	θ > 10 (rank : 1164)	NC score	0.290986 (rank : 285)
Query Neighborhood Hits	583	Target Neighborhood Hits	201	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL2_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.251054 (rank : 329)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	143
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVR_HUMAN
θ value	θ > 10 (rank : 1166)	NC score	0.256676 (rank : 319)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	139
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

R4RL1_HUMAN
θ value	θ > 10 (rank : 1167)	NC score	0.059419 (rank : 879)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL1_MOUSE
θ value	θ > 10 (rank : 1168)	NC score	0.056119 (rank : 985)
Query Neighborhood Hits	583	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

R4RL2_HUMAN
θ value	θ > 10 (rank : 1169)	NC score	0.061648 (rank : 822)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	36
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
θ value	θ > 10 (rank : 1170)	NC score	0.061610 (rank : 823)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

RAF1_HUMAN
θ value	θ > 10 (rank : 1171)	NC score	0.095069 (rank : 603)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 1172)	NC score	0.095625 (rank : 601)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RET_HUMAN
θ value	θ > 10 (rank : 1173)	NC score	0.142536 (rank : 429)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 1174)	NC score	0.143209 (rank : 427)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	91
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_HUMAN
θ value	θ > 10 (rank : 1175)	NC score	0.091720 (rank : 615)
Query Neighborhood Hits	583	Target Neighborhood Hits	891	Shared Neighborhood Hits	90
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 1176)	NC score	0.092186 (rank : 613)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 1177)	NC score	0.086466 (rank : 635)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 1178)	NC score	0.089497 (rank : 624)
Query Neighborhood Hits	583	Target Neighborhood Hits	776	Shared Neighborhood Hits	86
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.089640 (rank : 623)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 1180)	NC score	0.070399 (rank : 704)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 1181)	NC score	0.066240 (rank : 750)
Query Neighborhood Hits	583	Target Neighborhood Hits	1094	Shared Neighborhood Hits	94
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 1182)	NC score	0.084191 (rank : 641)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	88
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 1183)	NC score	0.084192 (rank : 640)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 1184)	NC score	0.131470 (rank : 464)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	87
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 1185)	NC score	0.133501 (rank : 452)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	86
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RTN4R_HUMAN
θ value	θ > 10 (rank : 1186)	NC score	0.060897 (rank : 848)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RTN4R_MOUSE
θ value	θ > 10 (rank : 1187)	NC score	0.057733 (rank : 935)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

RYK_HUMAN
θ value	θ > 10 (rank : 1188)	NC score	0.156210 (rank : 412)
Query Neighborhood Hits	583	Target Neighborhood Hits	701	Shared Neighborhood Hits	85
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1189)	NC score	0.154368 (rank : 414)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	84
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SCYL2_HUMAN
θ value	θ > 10 (rank : 1190)	NC score	0.050765 (rank : 1162)
Query Neighborhood Hits	583	Target Neighborhood Hits	632	Shared Neighborhood Hits	70
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1191)	NC score	0.052498 (rank : 1107)
Query Neighborhood Hits	583	Target Neighborhood Hits	603	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SIGIR_HUMAN
θ value	θ > 10 (rank : 1192)	NC score	0.050820 (rank : 1160)
Query Neighborhood Hits	583	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SIGIR_MOUSE
θ value	θ > 10 (rank : 1193)	NC score	0.102916 (rank : 573)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SIGL9_HUMAN
θ value	θ > 10 (rank : 1194)	NC score	0.104748 (rank : 565)
Query Neighborhood Hits	583	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SIRPG_HUMAN
θ value	θ > 10 (rank : 1195)	NC score	0.102928 (rank : 572)
Query Neighborhood Hits	583	Target Neighborhood Hits	359	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SLAF5_HUMAN
θ value	θ > 10 (rank : 1196)	NC score	0.058921 (rank : 893)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIB8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7	Gene names	CD84, SLAMF5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen) (Cell surface antigen MAX.3) (Hly9-beta).

SLAF5_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.059684 (rank : 873)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

SLAF9_MOUSE
θ value	θ > 10 (rank : 1198)	NC score	0.070732 (rank : 703)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

SLIT1_HUMAN
θ value	θ > 10 (rank : 1199)	NC score	0.067454 (rank : 732)
Query Neighborhood Hits	583	Target Neighborhood Hits	700	Shared Neighborhood Hits	66
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SLIT1_MOUSE
θ value	θ > 10 (rank : 1200)	NC score	0.069035 (rank : 713)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	67
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

SLIT2_HUMAN
θ value	θ > 10 (rank : 1201)	NC score	0.070811 (rank : 701)
Query Neighborhood Hits	583	Target Neighborhood Hits	708	Shared Neighborhood Hits	68
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	θ > 10 (rank : 1202)	NC score	0.069795 (rank : 708)
Query Neighborhood Hits	583	Target Neighborhood Hits	684	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT3_HUMAN
θ value	θ > 10 (rank : 1203)	NC score	0.068004 (rank : 722)
Query Neighborhood Hits	583	Target Neighborhood Hits	682	Shared Neighborhood Hits	66
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

SLIT3_MOUSE
θ value	θ > 10 (rank : 1204)	NC score	0.067734 (rank : 727)
Query Neighborhood Hits	583	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

SLK_HUMAN
θ value	θ > 10 (rank : 1205)	NC score	0.060150 (rank : 863)
Query Neighborhood Hits	583	Target Neighborhood Hits	1775	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	θ > 10 (rank : 1206)	NC score	0.059998 (rank : 868)
Query Neighborhood Hits	583	Target Neighborhood Hits	1798	Shared Neighborhood Hits	102
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

SN1L1_HUMAN
θ value	θ > 10 (rank : 1207)	NC score	0.059180 (rank : 889)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	93
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 1208)	NC score	0.060173 (rank : 861)
Query Neighborhood Hits	583	Target Neighborhood Hits	895	Shared Neighborhood Hits	94
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 1209)	NC score	0.061276 (rank : 834)
Query Neighborhood Hits	583	Target Neighborhood Hits	964	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 1210)	NC score	0.060891 (rank : 849)
Query Neighborhood Hits	583	Target Neighborhood Hits	944	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 1211)	NC score	0.050074 (rank : 1178)
Query Neighborhood Hits	583	Target Neighborhood Hits	855	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SRC_HUMAN
θ value	θ > 10 (rank : 1212)	NC score	0.115114 (rank : 530)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	90
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 1213)	NC score	0.115771 (rank : 524)
Query Neighborhood Hits	583	Target Neighborhood Hits	1033	Shared Neighborhood Hits	89
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SREC2_HUMAN
θ value	θ > 10 (rank : 1214)	NC score	0.059542 (rank : 875)
Query Neighborhood Hits	583	Target Neighborhood Hits	645	Shared Neighborhood Hits	62
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SREC2_MOUSE
θ value	θ > 10 (rank : 1215)	NC score	0.052639 (rank : 1105)
Query Neighborhood Hits	583	Target Neighborhood Hits	605	Shared Neighborhood Hits	56
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SREC_HUMAN
θ value	θ > 10 (rank : 1216)	NC score	0.055162 (rank : 1023)
Query Neighborhood Hits	583	Target Neighborhood Hits	645	Shared Neighborhood Hits	49
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

SRMS_HUMAN
θ value	θ > 10 (rank : 1217)	NC score	0.125380 (rank : 480)
Query Neighborhood Hits	583	Target Neighborhood Hits	946	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 1218)	NC score	0.124055 (rank : 483)
Query Neighborhood Hits	583	Target Neighborhood Hits	964	Shared Neighborhood Hits	88
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ST17A_HUMAN
θ value	θ > 10 (rank : 1219)	NC score	0.062788 (rank : 800)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 1220)	NC score	0.063349 (rank : 791)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 1221)	NC score	0.067320 (rank : 733)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_MOUSE
θ value	θ > 10 (rank : 1222)	NC score	0.050331 (rank : 1174)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

STK10_HUMAN
θ value	θ > 10 (rank : 1223)	NC score	0.056930 (rank : 958)
Query Neighborhood Hits	583	Target Neighborhood Hits	1921	Shared Neighborhood Hits	106
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
θ value	θ > 10 (rank : 1224)	NC score	0.053044 (rank : 1097)
Query Neighborhood Hits	583	Target Neighborhood Hits	2132	Shared Neighborhood Hits	100
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK11_HUMAN
θ value	θ > 10 (rank : 1225)	NC score	0.058732 (rank : 902)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	87
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK16_HUMAN
θ value	θ > 10 (rank : 1226)	NC score	0.061798 (rank : 818)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	86
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 1227)	NC score	0.061945 (rank : 813)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	86
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 1228)	NC score	0.072390 (rank : 688)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 1229)	NC score	0.072415 (rank : 687)
Query Neighborhood Hits	583	Target Neighborhood Hits	856	Shared Neighborhood Hits	88
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 1230)	NC score	0.068205 (rank : 720)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 1231)	NC score	0.068517 (rank : 719)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 1232)	NC score	0.066375 (rank : 747)
Query Neighborhood Hits	583	Target Neighborhood Hits	879	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 1233)	NC score	0.053240 (rank : 1092)
Query Neighborhood Hits	583	Target Neighborhood Hits	825	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 1234)	NC score	0.064452 (rank : 771)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 1235)	NC score	0.065613 (rank : 755)
Query Neighborhood Hits	583	Target Neighborhood Hits	877	Shared Neighborhood Hits	88
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK39_HUMAN
θ value	θ > 10 (rank : 1236)	NC score	0.063458 (rank : 789)
Query Neighborhood Hits	583	Target Neighborhood Hits	882	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 1237)	NC score	0.063910 (rank : 781)
Query Neighborhood Hits	583	Target Neighborhood Hits	915	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK3_HUMAN
θ value	θ > 10 (rank : 1238)	NC score	0.066636 (rank : 744)
Query Neighborhood Hits	583	Target Neighborhood Hits	861	Shared Neighborhood Hits	89
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK3_MOUSE
θ value	θ > 10 (rank : 1239)	NC score	0.067271 (rank : 734)
Query Neighborhood Hits	583	Target Neighborhood Hits	869	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

STK4_HUMAN
θ value	θ > 10 (rank : 1240)	NC score	0.067489 (rank : 730)
Query Neighborhood Hits	583	Target Neighborhood Hits	870	Shared Neighborhood Hits	89
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	θ > 10 (rank : 1241)	NC score	0.067703 (rank : 728)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_HUMAN
θ value	θ > 10 (rank : 1242)	NC score	0.060928 (rank : 846)
Query Neighborhood Hits	583	Target Neighborhood Hits	916	Shared Neighborhood Hits	92
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 1243)	NC score	0.059726 (rank : 872)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	92
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STYK1_HUMAN
θ value	θ > 10 (rank : 1244)	NC score	0.143781 (rank : 425)
Query Neighborhood Hits	583	Target Neighborhood Hits	786	Shared Neighborhood Hits	88
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 1245)	NC score	0.146355 (rank : 423)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	87
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK1_HUMAN
θ value	θ > 10 (rank : 1246)	NC score	0.051459 (rank : 1137)
Query Neighborhood Hits	583	Target Neighborhood Hits	1734	Shared Neighborhood Hits	98
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	θ > 10 (rank : 1247)	NC score	0.051372 (rank : 1143)
Query Neighborhood Hits	583	Target Neighborhood Hits	1720	Shared Neighborhood Hits	98
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	θ > 10 (rank : 1248)	NC score	0.058112 (rank : 920)
Query Neighborhood Hits	583	Target Neighborhood Hits	1172	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	θ > 10 (rank : 1249)	NC score	0.056060 (rank : 988)
Query Neighborhood Hits	583	Target Neighborhood Hits	1373	Shared Neighborhood Hits	91
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK3_HUMAN
θ value	θ > 10 (rank : 1250)	NC score	0.052348 (rank : 1112)
Query Neighborhood Hits	583	Target Neighborhood Hits	1494	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TAOK3_MOUSE
θ value	θ > 10 (rank : 1251)	NC score	0.051431 (rank : 1140)
Query Neighborhood Hits	583	Target Neighborhood Hits	1458	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TBK1_HUMAN
θ value	θ > 10 (rank : 1252)	NC score	0.053504 (rank : 1086)
Query Neighborhood Hits	583	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 1253)	NC score	0.053059 (rank : 1096)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TEC_HUMAN
θ value	θ > 10 (rank : 1254)	NC score	0.117976 (rank : 512)
Query Neighborhood Hits	583	Target Neighborhood Hits	1006	Shared Neighborhood Hits	88
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 1255)	NC score	0.117492 (rank : 515)
Query Neighborhood Hits	583	Target Neighborhood Hits	1006	Shared Neighborhood Hits	88
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK1_HUMAN
θ value	θ > 10 (rank : 1256)	NC score	0.089015 (rank : 625)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	93
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 1257)	NC score	0.090330 (rank : 620)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	96
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 1258)	NC score	0.094931 (rank : 604)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	90
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 1259)	NC score	0.094797 (rank : 605)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 1260)	NC score	0.083405 (rank : 646)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1261)	NC score	0.083008 (rank : 648)
Query Neighborhood Hits	583	Target Neighborhood Hits	1333	Shared Neighborhood Hits	96
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 1262)	NC score	0.068951 (rank : 716)
Query Neighborhood Hits	583	Target Neighborhood Hits	755	Shared Neighborhood Hits	87
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 1263)	NC score	0.069313 (rank : 710)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	87
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TGFR2_HUMAN
θ value	θ > 10 (rank : 1264)	NC score	0.074505 (rank : 679)
Query Neighborhood Hits	583	Target Neighborhood Hits	748	Shared Neighborhood Hits	85
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	θ > 10 (rank : 1265)	NC score	0.073513 (rank : 684)
Query Neighborhood Hits	583	Target Neighborhood Hits	748	Shared Neighborhood Hits	86
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TLR13_MOUSE
θ value	θ > 10 (rank : 1266)	NC score	0.055209 (rank : 1021)
Query Neighborhood Hits	583	Target Neighborhood Hits	335	Shared Neighborhood Hits	48
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

TLR3_HUMAN
θ value	θ > 10 (rank : 1267)	NC score	0.052111 (rank : 1117)
Query Neighborhood Hits	583	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR3_MOUSE
θ value	θ > 10 (rank : 1268)	NC score	0.054170 (rank : 1055)
Query Neighborhood Hits	583	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

TLR4_HUMAN
θ value	θ > 10 (rank : 1269)	NC score	0.050641 (rank : 1165)
Query Neighborhood Hits	583	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

TLR4_MOUSE
θ value	θ > 10 (rank : 1270)	NC score	0.051358 (rank : 1144)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUK6, Q9D691, Q9QZF5, Q9Z203	Gene names	Tlr4, Lps
Domain Architecture
Description	Toll-like receptor 4 precursor (CD284 antigen).

TLR5_HUMAN
θ value	θ > 10 (rank : 1271)	NC score	0.055060 (rank : 1027)
Query Neighborhood Hits	583	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

TLR5_MOUSE
θ value	θ > 10 (rank : 1272)	NC score	0.051714 (rank : 1129)
Query Neighborhood Hits	583	Target Neighborhood Hits	287	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

TLR9_HUMAN
θ value	θ > 10 (rank : 1273)	NC score	0.050695 (rank : 1163)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

TMM25_HUMAN
θ value	θ > 10 (rank : 1274)	NC score	0.071289 (rank : 697)
Query Neighborhood Hits	583	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TMM25_MOUSE
θ value	θ > 10 (rank : 1275)	NC score	0.081606 (rank : 653)
Query Neighborhood Hits	583	Target Neighborhood Hits	46	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TNI3K_HUMAN
θ value	θ > 10 (rank : 1276)	NC score	0.077769 (rank : 669)
Query Neighborhood Hits	583	Target Neighborhood Hits	1084	Shared Neighborhood Hits	90
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 1277)	NC score	0.078461 (rank : 667)
Query Neighborhood Hits	583	Target Neighborhood Hits	1079	Shared Neighborhood Hits	92
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIK_HUMAN
θ value	θ > 10 (rank : 1278)	NC score	0.057020 (rank : 956)
Query Neighborhood Hits	583	Target Neighborhood Hits	1570	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TNK1_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.134754 (rank : 447)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	89
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1280)	NC score	0.132606 (rank : 458)
Query Neighborhood Hits	583	Target Neighborhood Hits	806	Shared Neighborhood Hits	93
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 1281)	NC score	0.081676 (rank : 652)
Query Neighborhood Hits	583	Target Neighborhood Hits	605	Shared Neighborhood Hits	77
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 1282)	NC score	0.084145 (rank : 643)
Query Neighborhood Hits	583	Target Neighborhood Hits	618	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TPBG_HUMAN
θ value	θ > 10 (rank : 1283)	NC score	0.057486 (rank : 941)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	37
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

TPBG_MOUSE
θ value	θ > 10 (rank : 1284)	NC score	0.054162 (rank : 1057)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

TPSNR_HUMAN
θ value	θ > 10 (rank : 1285)	NC score	0.109656 (rank : 546)
Query Neighborhood Hits	583	Target Neighborhood Hits	330	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

TSK_HUMAN
θ value	θ > 10 (rank : 1286)	NC score	0.061106 (rank : 837)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

TSK_MOUSE
θ value	θ > 10 (rank : 1287)	NC score	0.053677 (rank : 1077)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

TSSK1_MOUSE
θ value	θ > 10 (rank : 1288)	NC score	0.055759 (rank : 996)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	86
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 1289)	NC score	0.054057 (rank : 1061)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	86
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 1290)	NC score	0.052348 (rank : 1113)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	86
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK4_HUMAN
θ value	θ > 10 (rank : 1291)	NC score	0.051808 (rank : 1126)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	88
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 1292)	NC score	0.055471 (rank : 1008)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	88
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 1293)	NC score	0.056760 (rank : 963)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 1294)	NC score	0.057049 (rank : 954)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	88
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTK_HUMAN
θ value	θ > 10 (rank : 1295)	NC score	0.050817 (rank : 1161)
Query Neighborhood Hits	583	Target Neighborhood Hits	816	Shared Neighborhood Hits	80
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TXK_HUMAN
θ value	θ > 10 (rank : 1296)	NC score	0.118384 (rank : 504)
Query Neighborhood Hits	583	Target Neighborhood Hits	971	Shared Neighborhood Hits	88
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 1297)	NC score	0.119526 (rank : 497)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	87
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TYK2_HUMAN
θ value	θ > 10 (rank : 1298)	NC score	0.111894 (rank : 539)
Query Neighborhood Hits	583	Target Neighborhood Hits	841	Shared Neighborhood Hits	88
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1299)	NC score	0.112779 (rank : 536)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UHMK1_HUMAN
θ value	θ > 10 (rank : 1300)	NC score	0.057659 (rank : 938)
Query Neighborhood Hits	583	Target Neighborhood Hits	808	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	θ > 10 (rank : 1301)	NC score	0.058220 (rank : 916)
Query Neighborhood Hits	583	Target Neighborhood Hits	809	Shared Neighborhood Hits	80
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ULK1_HUMAN
θ value	θ > 10 (rank : 1302)	NC score	0.063751 (rank : 783)
Query Neighborhood Hits	583	Target Neighborhood Hits	1121	Shared Neighborhood Hits	106
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 1303)	NC score	0.064874 (rank : 765)
Query Neighborhood Hits	583	Target Neighborhood Hits	1214	Shared Neighborhood Hits	128
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 1304)	NC score	0.064606 (rank : 768)
Query Neighborhood Hits	583	Target Neighborhood Hits	979	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 1305)	NC score	0.063747 (rank : 784)
Query Neighborhood Hits	583	Target Neighborhood Hits	943	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 1306)	NC score	0.065372 (rank : 759)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 1307)	NC score	0.065881 (rank : 752)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	88
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

VASN_HUMAN
θ value	θ > 10 (rank : 1308)	NC score	0.069070 (rank : 712)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	62
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

VASN_MOUSE
θ value	θ > 10 (rank : 1309)	NC score	0.070747 (rank : 702)
Query Neighborhood Hits	583	Target Neighborhood Hits	426	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

WEE1_MOUSE
θ value	θ > 10 (rank : 1310)	NC score	0.053997 (rank : 1064)
Query Neighborhood Hits	583	Target Neighborhood Hits	794	Shared Neighborhood Hits	79
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

YES_HUMAN
θ value	θ > 10 (rank : 1311)	NC score	0.115520 (rank : 525)
Query Neighborhood Hits	583	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 1312)	NC score	0.115419 (rank : 528)
Query Neighborhood Hits	583	Target Neighborhood Hits	1052	Shared Neighborhood Hits	90
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YSK4_HUMAN
θ value	θ > 10 (rank : 1313)	NC score	0.070988 (rank : 699)
Query Neighborhood Hits	583	Target Neighborhood Hits	921	Shared Neighborhood Hits	91
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ZAP70_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.126457 (rank : 478)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	87
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 1315)	NC score	0.127808 (rank : 473)
Query Neighborhood Hits	583	Target Neighborhood Hits	905	Shared Neighborhood Hits	89
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

DCC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	583	Target Neighborhood Hits	583	Shared Neighborhood Hits	583
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
NC score	0.980641 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	548
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NEO1_HUMAN
NC score	0.976628 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	583	Target Neighborhood Hits	530	Shared Neighborhood Hits	410
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
NC score	0.975594 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	583	Target Neighborhood Hits	523	Shared Neighborhood Hits	410
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DSCAM_HUMAN
NC score	0.931651 (rank : 5)	θ value	1.00825e-67 (rank : 8)
Query Neighborhood Hits	583	Target Neighborhood Hits	524	Shared Neighborhood Hits	410
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
NC score	0.930405 (rank : 6)	θ value	4.37348e-71 (rank : 5)
Query Neighborhood Hits	583	Target Neighborhood Hits	589	Shared Neighborhood Hits	417
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

SDK2_HUMAN
NC score	0.924106 (rank : 7)	θ value	5.17823e-64 (rank : 14)
Query Neighborhood Hits	583	Target Neighborhood Hits	495	Shared Neighborhood Hits	404
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
NC score	0.922673 (rank : 8)	θ value	1.90147e-66 (rank : 12)
Query Neighborhood Hits	583	Target Neighborhood Hits	480	Shared Neighborhood Hits	402
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

PUNC_HUMAN
NC score	0.922211 (rank : 9)	θ value	5.91091e-68 (rank : 7)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	354
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

SDK1_HUMAN
NC score	0.921132 (rank : 10)	θ value	2.93355e-67 (rank : 11)
Query Neighborhood Hits	583	Target Neighborhood Hits	511	Shared Neighborhood Hits	407
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
NC score	0.920196 (rank : 11)	θ value	2.24614e-67 (rank : 10)
Query Neighborhood Hits	583	Target Neighborhood Hits	495	Shared Neighborhood Hits	406
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PUNC_MOUSE
NC score	0.917808 (rank : 12)	θ value	2.24614e-67 (rank : 9)
Query Neighborhood Hits	583	Target Neighborhood Hits	501	Shared Neighborhood Hits	349
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

L1CAM_HUMAN
NC score	0.912396 (rank : 13)	θ value	1.19377e-60 (rank : 15)
Query Neighborhood Hits	583	Target Neighborhood Hits	457	Shared Neighborhood Hits	388
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NRCAM_MOUSE
NC score	0.911783 (rank : 14)	θ value	7.75577e-52 (rank : 22)
Query Neighborhood Hits	583	Target Neighborhood Hits	432	Shared Neighborhood Hits	374
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NRCAM_HUMAN
NC score	0.910815 (rank : 15)	θ value	1.08223e-53 (rank : 20)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	381
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NFASC_HUMAN
NC score	0.908678 (rank : 16)	θ value	1.72781e-51 (rank : 23)
Query Neighborhood Hits	583	Target Neighborhood Hits	497	Shared Neighborhood Hits	394
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

L1CAM_MOUSE
NC score	0.908165 (rank : 17)	θ value	3.36421e-55 (rank : 18)
Query Neighborhood Hits	583	Target Neighborhood Hits	457	Shared Neighborhood Hits	388
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

ROBO3_HUMAN
NC score	0.902781 (rank : 18)	θ value	5.93839e-52 (rank : 21)
Query Neighborhood Hits	583	Target Neighborhood Hits	570	Shared Neighborhood Hits	400
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO3_MOUSE
NC score	0.901833 (rank : 19)	θ value	3.84914e-51 (rank : 27)
Query Neighborhood Hits	583	Target Neighborhood Hits	524	Shared Neighborhood Hits	391
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

ROBO2_HUMAN
NC score	0.901760 (rank : 20)	θ value	1.72781e-51 (rank : 24)
Query Neighborhood Hits	583	Target Neighborhood Hits	479	Shared Neighborhood Hits	387
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
NC score	0.901626 (rank : 21)	θ value	1.91031e-50 (rank : 28)
Query Neighborhood Hits	583	Target Neighborhood Hits	504	Shared Neighborhood Hits	402
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

NFASC_MOUSE
NC score	0.900938 (rank : 22)	θ value	3.26607e-42 (rank : 37)
Query Neighborhood Hits	583	Target Neighborhood Hits	475	Shared Neighborhood Hits	391
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

CHL1_HUMAN
NC score	0.896747 (rank : 23)	θ value	6.77864e-56 (rank : 17)
Query Neighborhood Hits	583	Target Neighborhood Hits	413	Shared Neighborhood Hits	367
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

CNTN2_HUMAN
NC score	0.895640 (rank : 24)	θ value	1.73584e-35 (rank : 42)
Query Neighborhood Hits	583	Target Neighborhood Hits	440	Shared Neighborhood Hits	393
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN5_HUMAN
NC score	0.895337 (rank : 25)	θ value	6.58091e-43 (rank : 35)
Query Neighborhood Hits	583	Target Neighborhood Hits	446	Shared Neighborhood Hits	394
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

ROBO1_MOUSE
NC score	0.894856 (rank : 26)	θ value	2.94719e-51 (rank : 25)
Query Neighborhood Hits	583	Target Neighborhood Hits	559	Shared Neighborhood Hits	391
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

CNTN2_MOUSE
NC score	0.893756 (rank : 27)	θ value	6.82597e-32 (rank : 45)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	392
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN3_HUMAN
NC score	0.893380 (rank : 28)	θ value	2.50074e-42 (rank : 36)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	395
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

ROBO1_HUMAN
NC score	0.890777 (rank : 29)	θ value	3.84914e-51 (rank : 26)
Query Neighborhood Hits	583	Target Neighborhood Hits	529	Shared Neighborhood Hits	382
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

CHL1_MOUSE
NC score	0.888796 (rank : 30)	θ value	8.87376e-48 (rank : 30)
Query Neighborhood Hits	583	Target Neighborhood Hits	402	Shared Neighborhood Hits	364
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN4_HUMAN
NC score	0.888498 (rank : 31)	θ value	1.36902e-48 (rank : 29)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	382
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN5_MOUSE
NC score	0.888259 (rank : 32)	θ value	2.58786e-39 (rank : 40)
Query Neighborhood Hits	583	Target Neighborhood Hits	434	Shared Neighborhood Hits	382
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

CNTN4_MOUSE
NC score	0.888155 (rank : 33)	θ value	8.87376e-48 (rank : 31)
Query Neighborhood Hits	583	Target Neighborhood Hits	445	Shared Neighborhood Hits	384
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN3_MOUSE
NC score	0.887955 (rank : 34)	θ value	6.15952e-41 (rank : 38)
Query Neighborhood Hits	583	Target Neighborhood Hits	447	Shared Neighborhood Hits	387
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN1_MOUSE
NC score	0.883627 (rank : 35)	θ value	3.27365e-34 (rank : 44)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	381
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN1_HUMAN
NC score	0.883167 (rank : 36)	θ value	2.96089e-35 (rank : 43)
Query Neighborhood Hits	583	Target Neighborhood Hits	431	Shared Neighborhood Hits	379
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

CNTN6_HUMAN
NC score	0.882813 (rank : 37)	θ value	4.86918e-46 (rank : 32)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	370
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

BOC_HUMAN
NC score	0.882547 (rank : 38)	θ value	2.04573e-44 (rank : 33)
Query Neighborhood Hits	583	Target Neighborhood Hits	543	Shared Neighborhood Hits	357
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CNTN6_MOUSE
NC score	0.881244 (rank : 39)	θ value	5.95217e-44 (rank : 34)
Query Neighborhood Hits	583	Target Neighborhood Hits	429	Shared Neighborhood Hits	375
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

BOC_MOUSE
NC score	0.877478 (rank : 40)	θ value	1.05066e-40 (rank : 39)
Query Neighborhood Hits	583	Target Neighborhood Hits	433	Shared Neighborhood Hits	341
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

NCAM2_MOUSE
NC score	0.867085 (rank : 41)	θ value	1.85889e-29 (rank : 50)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	400
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

CDON_MOUSE
NC score	0.866702 (rank : 42)	θ value	1.57365e-28 (rank : 52)
Query Neighborhood Hits	583	Target Neighborhood Hits	410	Shared Neighborhood Hits	347
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_HUMAN
NC score	0.865779 (rank : 43)	θ value	1.73987e-27 (rank : 53)
Query Neighborhood Hits	583	Target Neighborhood Hits	412	Shared Neighborhood Hits	345
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NCAM2_HUMAN
NC score	0.858601 (rank : 44)	θ value	1.62847e-25 (rank : 56)
Query Neighborhood Hits	583	Target Neighborhood Hits	441	Shared Neighborhood Hits	389
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCA11_HUMAN
NC score	0.843799 (rank : 45)	θ value	1.16434e-31 (rank : 47)
Query Neighborhood Hits	583	Target Neighborhood Hits	443	Shared Neighborhood Hits	368
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA12_HUMAN
NC score	0.836827 (rank : 46)	θ value	8.91499e-32 (rank : 46)
Query Neighborhood Hits	583	Target Neighborhood Hits	437	Shared Neighborhood Hits	363
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCA12_MOUSE
NC score	0.836738 (rank : 47)	θ value	1.08979e-29 (rank : 49)
Query Neighborhood Hits	583	Target Neighborhood Hits	399	Shared Neighborhood Hits	350
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NCA11_MOUSE
NC score	0.824646 (rank : 48)	θ value	3.17079e-29 (rank : 51)
Query Neighborhood Hits	583	Target Neighborhood Hits	661	Shared Neighborhood Hits	383
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

OBSL1_HUMAN
NC score	0.814468 (rank : 49)	θ value	5.99374e-20 (rank : 77)
Query Neighborhood Hits	583	Target Neighborhood Hits	354	Shared Neighborhood Hits	288
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ROBO4_HUMAN
NC score	0.796166 (rank : 50)	θ value	3.28887e-18 (rank : 84)
Query Neighborhood Hits	583	Target Neighborhood Hits	364	Shared Neighborhood Hits	274
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

ROBO4_MOUSE
NC score	0.795573 (rank : 51)	θ value	4.91457e-14 (rank : 103)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	280
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MYPN_HUMAN
NC score	0.794132 (rank : 52)	θ value	1.29031e-22 (rank : 64)
Query Neighborhood Hits	583	Target Neighborhood Hits	418	Shared Neighborhood Hits	294
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

FGRL1_HUMAN
NC score	0.792314 (rank : 53)	θ value	2.13179e-17 (rank : 86)
Query Neighborhood Hits	583	Target Neighborhood Hits	335	Shared Neighborhood Hits	284
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

MYOTI_MOUSE
NC score	0.790769 (rank : 54)	θ value	9.26847e-13 (rank : 110)
Query Neighborhood Hits	583	Target Neighborhood Hits	297	Shared Neighborhood Hits	264
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYOTI_HUMAN
NC score	0.789148 (rank : 55)	θ value	3.52202e-12 (rank : 119)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	266
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

FGRL1_MOUSE
NC score	0.789035 (rank : 56)	θ value	1.80466e-16 (rank : 90)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	292
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

MYPN_MOUSE
NC score	0.785175 (rank : 57)	θ value	8.36355e-22 (rank : 70)
Query Neighborhood Hits	583	Target Neighborhood Hits	421	Shared Neighborhood Hits	288
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

MYOM2_HUMAN
NC score	0.778021 (rank : 58)	θ value	3.17815e-21 (rank : 72)
Query Neighborhood Hits	583	Target Neighborhood Hits	341	Shared Neighborhood Hits	301
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOM1_HUMAN
NC score	0.770591 (rank : 59)	θ value	2.87452e-22 (rank : 66)
Query Neighborhood Hits	583	Target Neighborhood Hits	405	Shared Neighborhood Hits	315
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MAMC1_HUMAN
NC score	0.768446 (rank : 60)	θ value	8.95645e-16 (rank : 94)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	301
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
NC score	0.767371 (rank : 61)	θ value	8.95645e-16 (rank : 95)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	301
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYOM1_MOUSE
NC score	0.766304 (rank : 62)	θ value	2.5182e-18 (rank : 82)
Query Neighborhood Hits	583	Target Neighborhood Hits	415	Shared Neighborhood Hits	329
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

LSAMP_MOUSE
NC score	0.764291 (rank : 63)	θ value	1.09485e-13 (rank : 105)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

NPHN_HUMAN
NC score	0.762066 (rank : 64)	θ value	1.68911e-14 (rank : 100)
Query Neighborhood Hits	583	Target Neighborhood Hits	362	Shared Neighborhood Hits	301
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

LSAMP_HUMAN
NC score	0.761636 (rank : 65)	θ value	4.59992e-12 (rank : 120)
Query Neighborhood Hits	583	Target Neighborhood Hits	347	Shared Neighborhood Hits	302
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MDGA1_HUMAN
NC score	0.758907 (rank : 66)	θ value	3.18553e-13 (rank : 107)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	300
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

OPCM_HUMAN
NC score	0.752045 (rank : 67)	θ value	1.58096e-12 (rank : 112)
Query Neighborhood Hits	583	Target Neighborhood Hits	332	Shared Neighborhood Hits	298
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

NEGR1_HUMAN
NC score	0.750843 (rank : 68)	θ value	3.89403e-11 (rank : 127)
Query Neighborhood Hits	583	Target Neighborhood Hits	346	Shared Neighborhood Hits	302
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

PTPRD_MOUSE
NC score	0.748564 (rank : 69)	θ value	2.4834e-66 (rank : 13)
Query Neighborhood Hits	583	Target Neighborhood Hits	491	Shared Neighborhood Hits	370
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

NEGR1_MOUSE
NC score	0.748129 (rank : 70)	θ value	8.67504e-11 (rank : 131)
Query Neighborhood Hits	583	Target Neighborhood Hits	349	Shared Neighborhood Hits	301
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

NPHN_MOUSE
NC score	0.745553 (rank : 71)	θ value	1.133e-10 (rank : 136)
Query Neighborhood Hits	583	Target Neighborhood Hits	370	Shared Neighborhood Hits	301
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NTRI_MOUSE
NC score	0.743835 (rank : 72)	θ value	5.62301e-10 (rank : 143)
Query Neighborhood Hits	583	Target Neighborhood Hits	342	Shared Neighborhood Hits	303
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

PTPRF_HUMAN
NC score	0.742998 (rank : 73)	θ value	7.24236e-58 (rank : 16)
Query Neighborhood Hits	583	Target Neighborhood Hits	489	Shared Neighborhood Hits	374
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

NTRI_HUMAN
NC score	0.741041 (rank : 74)	θ value	8.67504e-11 (rank : 132)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	304
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

PTPRD_HUMAN
NC score	0.737436 (rank : 75)	θ value	1.66191e-70 (rank : 6)
Query Neighborhood Hits	583	Target Neighborhood Hits	485	Shared Neighborhood Hits	363
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRS_HUMAN
NC score	0.728141 (rank : 76)	θ value	3.36421e-55 (rank : 19)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	358
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

VCAM1_MOUSE
NC score	0.704792 (rank : 77)	θ value	1.53129e-07 (rank : 188)
Query Neighborhood Hits	583	Target Neighborhood Hits	320	Shared Neighborhood Hits	267
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

MYPC1_HUMAN
NC score	0.703466 (rank : 78)	θ value	2.20605e-14 (rank : 101)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	273
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYPC2_MOUSE
NC score	0.702673 (rank : 79)	θ value	8.10077e-17 (rank : 88)
Query Neighborhood Hits	583	Target Neighborhood Hits	297	Shared Neighborhood Hits	271
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MYPC2_HUMAN
NC score	0.701184 (rank : 80)	θ value	2.35696e-16 (rank : 91)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	285
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

VCAM1_HUMAN
NC score	0.697518 (rank : 81)	θ value	2.61198e-07 (rank : 191)
Query Neighborhood Hits	583	Target Neighborhood Hits	352	Shared Neighborhood Hits	271
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

FNDC3_HUMAN
NC score	0.694668 (rank : 82)	θ value	5.07402e-19 (rank : 79)
Query Neighborhood Hits	583	Target Neighborhood Hits	196	Shared Neighborhood Hits	167
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

MAG_MOUSE
NC score	0.692780 (rank : 83)	θ value	9.26847e-13 (rank : 108)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	252
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

FNDC3_MOUSE
NC score	0.692099 (rank : 84)	θ value	3.07829e-16 (rank : 92)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	170
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

KIRR2_HUMAN
NC score	0.691811 (rank : 85)	θ value	3.52202e-12 (rank : 118)
Query Neighborhood Hits	583	Target Neighborhood Hits	321	Shared Neighborhood Hits	249
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

MAG_HUMAN
NC score	0.688863 (rank : 86)	θ value	2.52405e-10 (rank : 140)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	254
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

LU_HUMAN
NC score	0.688319 (rank : 87)	θ value	3.19293e-05 (rank : 237)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	253
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

KIRR2_MOUSE
NC score	0.685518 (rank : 88)	θ value	4.91457e-14 (rank : 102)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	255
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

FSTL5_HUMAN
NC score	0.680851 (rank : 89)	θ value	6.00763e-12 (rank : 121)
Query Neighborhood Hits	583	Target Neighborhood Hits	347	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

MYPC3_HUMAN
NC score	0.678823 (rank : 90)	θ value	2.98157e-11 (rank : 126)
Query Neighborhood Hits	583	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
NC score	0.678628 (rank : 91)	θ value	1.2105e-12 (rank : 111)
Query Neighborhood Hits	583	Target Neighborhood Hits	310	Shared Neighborhood Hits	281
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

FSTL4_HUMAN
NC score	0.678235 (rank : 92)	θ value	4.76016e-09 (rank : 152)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	268
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

RAGE_HUMAN
NC score	0.677074 (rank : 93)	θ value	9.29e-05 (rank : 249)
Query Neighborhood Hits	583	Target Neighborhood Hits	269	Shared Neighborhood Hits	243
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

FSTL5_MOUSE
NC score	0.676816 (rank : 94)	θ value	3.18553e-13 (rank : 106)
Query Neighborhood Hits	583	Target Neighborhood Hits	355	Shared Neighborhood Hits	258
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

FSTL4_MOUSE
NC score	0.671810 (rank : 95)	θ value	3.64472e-09 (rank : 151)
Query Neighborhood Hits	583	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

TMIGD_HUMAN
NC score	0.668894 (rank : 96)	θ value	0.000121331 (rank : 256)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	222
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

MUC18_HUMAN
NC score	0.665666 (rank : 97)	θ value	2.79066e-09 (rank : 150)
Query Neighborhood Hits	583	Target Neighborhood Hits	275	Shared Neighborhood Hits	229
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

MALT1_HUMAN
NC score	0.662606 (rank : 98)	θ value	0.00298849 (rank : 300)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	211
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

SN_MOUSE
NC score	0.659204 (rank : 99)	θ value	2.88788e-06 (rank : 215)
Query Neighborhood Hits	583	Target Neighborhood Hits	416	Shared Neighborhood Hits	298
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

SN_HUMAN
NC score	0.656858 (rank : 100)	θ value	6.87365e-08 (rank : 179)
Query Neighborhood Hits	583	Target Neighborhood Hits	434	Shared Neighborhood Hits	292
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

MUC18_MOUSE
NC score	0.653407 (rank : 101)	θ value	1.02475e-11 (rank : 122)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	233
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

CD22_MOUSE
NC score	0.651359 (rank : 102)	θ value	0.0330416 (rank : 337)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	251
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

TMIGD_MOUSE
NC score	0.650839 (rank : 103)	θ value	8.97725e-08 (rank : 182)
Query Neighborhood Hits	583	Target Neighborhood Hits	234	Shared Neighborhood Hits	224
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

ICAM5_MOUSE
NC score	0.650132 (rank : 104)	θ value	2.13673e-09 (rank : 147)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	250
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

CD22_HUMAN
NC score	0.646854 (rank : 105)	θ value	8.40245e-06 (rank : 223)
Query Neighborhood Hits	583	Target Neighborhood Hits	365	Shared Neighborhood Hits	265
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

RAGE_MOUSE
NC score	0.644228 (rank : 106)	θ value	1.43324e-05 (rank : 231)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	225
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

KIRR3_HUMAN
NC score	0.642095 (rank : 107)	θ value	1.06045e-08 (rank : 160)
Query Neighborhood Hits	583	Target Neighborhood Hits	302	Shared Neighborhood Hits	246
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

JAM1_HUMAN
NC score	0.640132 (rank : 108)	θ value	0.00134147 (rank : 286)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

KIRR1_HUMAN
NC score	0.637958 (rank : 109)	θ value	2.98157e-11 (rank : 125)
Query Neighborhood Hits	583	Target Neighborhood Hits	401	Shared Neighborhood Hits	258
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

CEAM5_HUMAN
NC score	0.637182 (rank : 110)	θ value	8.67504e-11 (rank : 130)
Query Neighborhood Hits	583	Target Neighborhood Hits	343	Shared Neighborhood Hits	279
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

KIRR3_MOUSE
NC score	0.636038 (rank : 111)	θ value	8.11959e-09 (rank : 154)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

KIRR1_MOUSE
NC score	0.635965 (rank : 112)	θ value	3.52202e-12 (rank : 117)
Query Neighborhood Hits	583	Target Neighborhood Hits	403	Shared Neighborhood Hits	260
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

JAM3_HUMAN
NC score	0.634180 (rank : 113)	θ value	1.43324e-05 (rank : 229)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	245
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

ICAM5_HUMAN
NC score	0.632375 (rank : 114)	θ value	1.06045e-08 (rank : 159)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	238
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

JAM3_MOUSE
NC score	0.631724 (rank : 115)	θ value	0.00020696 (rank : 260)
Query Neighborhood Hits	583	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

CEAM1_MOUSE
NC score	0.625956 (rank : 116)	θ value	3.29651e-10 (rank : 141)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	272
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

NPTN_HUMAN
NC score	0.618768 (rank : 117)	θ value	0.000158464 (rank : 259)
Query Neighborhood Hits	583	Target Neighborhood Hits	212	Shared Neighborhood Hits	201
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PGBM_HUMAN
NC score	0.616404 (rank : 118)	θ value	3.39556e-23 (rank : 62)
Query Neighborhood Hits	583	Target Neighborhood Hits	1113	Shared Neighborhood Hits	385
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

HMCN1_HUMAN
NC score	0.615906 (rank : 119)	θ value	1.85459e-37 (rank : 41)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	377
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

JAM1_MOUSE
NC score	0.613283 (rank : 120)	θ value	0.000786445 (rank : 277)
Query Neighborhood Hits	583	Target Neighborhood Hits	287	Shared Neighborhood Hits	245
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

JAM2_HUMAN
NC score	0.606306 (rank : 121)	θ value	0.000270298 (rank : 266)
Query Neighborhood Hits	583	Target Neighborhood Hits	304	Shared Neighborhood Hits	276
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

NPTN_MOUSE
NC score	0.605541 (rank : 122)	θ value	0.00102713 (rank : 282)
Query Neighborhood Hits	583	Target Neighborhood Hits	216	Shared Neighborhood Hits	201
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

IGS4B_MOUSE
NC score	0.604760 (rank : 123)	θ value	4.45536e-07 (rank : 195)
Query Neighborhood Hits	583	Target Neighborhood Hits	328	Shared Neighborhood Hits	262
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

LRIG1_HUMAN
NC score	0.604665 (rank : 124)	θ value	2.43343e-21 (rank : 71)
Query Neighborhood Hits	583	Target Neighborhood Hits	654	Shared Neighborhood Hits	317
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG2_HUMAN
NC score	0.603220 (rank : 125)	θ value	1.5242e-23 (rank : 59)
Query Neighborhood Hits	583	Target Neighborhood Hits	595	Shared Neighborhood Hits	312
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

PGBM_MOUSE
NC score	0.602947 (rank : 126)	θ value	1.5773e-20 (rank : 76)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	374
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

MYBPH_MOUSE
NC score	0.601401 (rank : 127)	θ value	1.87187e-05 (rank : 234)
Query Neighborhood Hits	583	Target Neighborhood Hits	290	Shared Neighborhood Hits	242
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

LRIG2_MOUSE
NC score	0.599620 (rank : 128)	θ value	3.75424e-22 (rank : 68)
Query Neighborhood Hits	583	Target Neighborhood Hits	586	Shared Neighborhood Hits	309
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

CEA20_HUMAN
NC score	0.598244 (rank : 129)	θ value	4.0297e-08 (rank : 173)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	203
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

IGS4B_HUMAN
NC score	0.594397 (rank : 130)	θ value	1.99992e-07 (rank : 190)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	249
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

LRIG1_MOUSE
NC score	0.594073 (rank : 131)	θ value	3.39556e-23 (rank : 60)
Query Neighborhood Hits	583	Target Neighborhood Hits	627	Shared Neighborhood Hits	313
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

KAZD1_MOUSE
NC score	0.592969 (rank : 132)	θ value	8.11959e-09 (rank : 153)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

MYBPH_HUMAN
NC score	0.592013 (rank : 133)	θ value	1.69304e-06 (rank : 210)
Query Neighborhood Hits	583	Target Neighborhood Hits	256	Shared Neighborhood Hits	232
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

JAM2_MOUSE
NC score	0.587183 (rank : 134)	θ value	0.00102713 (rank : 280)
Query Neighborhood Hits	583	Target Neighborhood Hits	292	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

VSIG2_HUMAN
NC score	0.578750 (rank : 135)	θ value	6.43352e-06 (rank : 222)
Query Neighborhood Hits	583	Target Neighborhood Hits	321	Shared Neighborhood Hits	250
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

LRIG3_MOUSE
NC score	0.577434 (rank : 136)	θ value	1.2077e-20 (rank : 74)
Query Neighborhood Hits	583	Target Neighborhood Hits	611	Shared Neighborhood Hits	314
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

CEAM1_HUMAN
NC score	0.573469 (rank : 137)	θ value	5.81887e-07 (rank : 197)
Query Neighborhood Hits	583	Target Neighborhood Hits	348	Shared Neighborhood Hits	262
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

LRIG3_HUMAN
NC score	0.571247 (rank : 138)	θ value	1.5773e-20 (rank : 75)
Query Neighborhood Hits	583	Target Neighborhood Hits	601	Shared Neighborhood Hits	311
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

CI094_HUMAN
NC score	0.571122 (rank : 139)	θ value	1.63604e-09 (rank : 145)
Query Neighborhood Hits	583	Target Neighborhood Hits	310	Shared Neighborhood Hits	231
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

FINC_MOUSE
NC score	0.565915 (rank : 140)	θ value	4.15078e-21 (rank : 73)
Query Neighborhood Hits	583	Target Neighborhood Hits	309	Shared Neighborhood Hits	181
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FCRL5_HUMAN
NC score	0.564135 (rank : 141)	θ value	0.000786445 (rank : 276)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	223
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

SIG11_HUMAN
NC score	0.563638 (rank : 142)	θ value	0.00020696 (rank : 262)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	246
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

FINC_HUMAN
NC score	0.559342 (rank : 143)	θ value	2.97466e-19 (rank : 78)
Query Neighborhood Hits	583	Target Neighborhood Hits	302	Shared Neighborhood Hits	183
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

VSIG2_MOUSE
NC score	0.556298 (rank : 144)	θ value	0.00228821 (rank : 298)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	235
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

TITIN_HUMAN
NC score	0.553886 (rank : 145)	θ value	2.59387e-31 (rank : 48)
Query Neighborhood Hits	583	Target Neighborhood Hits	2923	Shared Neighborhood Hits	498
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

SIG10_HUMAN
NC score	0.553872 (rank : 146)	θ value	0.00102713 (rank : 283)
Query Neighborhood Hits	583	Target Neighborhood Hits	363	Shared Neighborhood Hits	244
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

KAZD1_HUMAN
NC score	0.547330 (rank : 147)	θ value	1.53129e-07 (rank : 186)
Query Neighborhood Hits	583	Target Neighborhood Hits	248	Shared Neighborhood Hits	170
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

BASI_HUMAN
NC score	0.544597 (rank : 148)	θ value	0.0330416 (rank : 336)
Query Neighborhood Hits	583	Target Neighborhood Hits	211	Shared Neighborhood Hits	196
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

BASI_MOUSE
NC score	0.542471 (rank : 149)	θ value	0.00509761 (rank : 304)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	205
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

MFA3L_HUMAN
NC score	0.540676 (rank : 150)	θ value	0.0330416 (rank : 341)
Query Neighborhood Hits	583	Target Neighborhood Hits	230	Shared Neighborhood Hits	209
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

FCRL2_HUMAN
NC score	0.530194 (rank : 151)	θ value	0.47712 (rank : 406)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

CEAM6_HUMAN
NC score	0.512689 (rank : 152)	θ value	0.000270298 (rank : 263)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	260
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

PTK7_HUMAN
NC score	0.504585 (rank : 153)	θ value	2.87452e-22 (rank : 67)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	356
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

CD166_MOUSE
NC score	0.502506 (rank : 154)	θ value	0.00102713 (rank : 278)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	203
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

NRG2_HUMAN
NC score	0.500736 (rank : 155)	θ value	0.21417 (rank : 391)
Query Neighborhood Hits	583	Target Neighborhood Hits	419	Shared Neighborhood Hits	237
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

IBP7_HUMAN
NC score	0.498651 (rank : 156)	θ value	0.21417 (rank : 386)
Query Neighborhood Hits	583	Target Neighborhood Hits	220	Shared Neighborhood Hits	166
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

VSIG4_HUMAN
NC score	0.498536 (rank : 157)	θ value	0.0252991 (rank : 335)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

GPA33_MOUSE
NC score	0.496188 (rank : 158)	θ value	9.29e-05 (rank : 247)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	214
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

NRG2_MOUSE
NC score	0.494103 (rank : 159)	θ value	0.21417 (rank : 392)
Query Neighborhood Hits	583	Target Neighborhood Hits	392	Shared Neighborhood Hits	237
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

IBP7_MOUSE
NC score	0.483793 (rank : 160)	θ value	0.0193708 (rank : 325)
Query Neighborhood Hits	583	Target Neighborhood Hits	230	Shared Neighborhood Hits	163
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

CD166_HUMAN
NC score	0.474954 (rank : 161)	θ value	0.0148317 (rank : 319)
Query Neighborhood Hits	583	Target Neighborhood Hits	247	Shared Neighborhood Hits	194
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

MUSK_MOUSE
NC score	0.468042 (rank : 162)	θ value	1.6852e-22 (rank : 65)
Query Neighborhood Hits	583	Target Neighborhood Hits	1057	Shared Neighborhood Hits	338
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MFA3L_MOUSE
NC score	0.467520 (rank : 163)	θ value	0.0193708 (rank : 328)
Query Neighborhood Hits	583	Target Neighborhood Hits	214	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

MUSK_HUMAN
NC score	0.467033 (rank : 164)	θ value	3.75424e-22 (rank : 69)
Query Neighborhood Hits	583	Target Neighborhood Hits	1074	Shared Neighborhood Hits	342
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

GPA33_HUMAN
NC score	0.464749 (rank : 165)	θ value	0.000270298 (rank : 265)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

CEAM8_HUMAN
NC score	0.462286 (rank : 166)	θ value	7.59969e-07 (rank : 201)
Query Neighborhood Hits	583	Target Neighborhood Hits	264	Shared Neighborhood Hits	229
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

SIGL5_MOUSE
NC score	0.451965 (rank : 167)	θ value	0.00509761 (rank : 309)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	238
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

PSG3_HUMAN
NC score	0.450834 (rank : 168)	θ value	4.0297e-08 (rank : 175)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	214
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

ATL3_HUMAN
NC score	0.450059 (rank : 169)	θ value	2.36244e-08 (rank : 168)
Query Neighborhood Hits	583	Target Neighborhood Hits	414	Shared Neighborhood Hits	264
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PSG4_HUMAN
NC score	0.447510 (rank : 170)	θ value	1.17247e-07 (rank : 185)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	211
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

PSG8_HUMAN
NC score	0.443975 (rank : 171)	θ value	5.81887e-07 (rank : 199)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	213
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

IL6RB_HUMAN
NC score	0.438954 (rank : 172)	θ value	7.59969e-07 (rank : 202)
Query Neighborhood Hits	583	Target Neighborhood Hits	181	Shared Neighborhood Hits	131
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

COCA1_MOUSE
NC score	0.438519 (rank : 173)	θ value	4.44505e-15 (rank : 97)
Query Neighborhood Hits	583	Target Neighborhood Hits	467	Shared Neighborhood Hits	175
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PSG7_HUMAN
NC score	0.434528 (rank : 174)	θ value	5.81887e-07 (rank : 198)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	211
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

USH2A_HUMAN
NC score	0.434107 (rank : 175)	θ value	6.18819e-25 (rank : 58)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	187
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

PSG11_HUMAN
NC score	0.429999 (rank : 176)	θ value	1.87187e-05 (rank : 235)
Query Neighborhood Hits	583	Target Neighborhood Hits	223	Shared Neighborhood Hits	203
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG1_HUMAN
NC score	0.428257 (rank : 177)	θ value	1.29631e-06 (rank : 207)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	207
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG2_HUMAN
NC score	0.425721 (rank : 178)	θ value	8.97725e-08 (rank : 181)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	207
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

VGFR1_HUMAN
NC score	0.425321 (rank : 179)	θ value	5.25075e-16 (rank : 93)
Query Neighborhood Hits	583	Target Neighborhood Hits	1109	Shared Neighborhood Hits	341
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

COCA1_HUMAN
NC score	0.424923 (rank : 180)	θ value	1.058e-16 (rank : 89)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	169
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PSG6_HUMAN
NC score	0.422423 (rank : 181)	θ value	9.92553e-07 (rank : 204)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	201
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

VGFR1_MOUSE
NC score	0.420634 (rank : 182)	θ value	1.58096e-12 (rank : 113)
Query Neighborhood Hits	583	Target Neighborhood Hits	1118	Shared Neighborhood Hits	345
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

USH2A_MOUSE
NC score	0.418674 (rank : 183)	θ value	1.73987e-27 (rank : 54)
Query Neighborhood Hits	583	Target Neighborhood Hits	626	Shared Neighborhood Hits	181
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

PSG10_HUMAN
NC score	0.417471 (rank : 184)	θ value	2.88788e-06 (rank : 212)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	197
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

ESAM_HUMAN
NC score	0.414694 (rank : 185)	θ value	0.0431538 (rank : 347)
Query Neighborhood Hits	583	Target Neighborhood Hits	251	Shared Neighborhood Hits	191
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

OBSCN_HUMAN
NC score	0.412137 (rank : 186)	θ value	2.5182e-18 (rank : 83)
Query Neighborhood Hits	583	Target Neighborhood Hits	1931	Shared Neighborhood Hits	423
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

IL1R2_HUMAN
NC score	0.408902 (rank : 187)	θ value	2.21117e-06 (rank : 211)
Query Neighborhood Hits	583	Target Neighborhood Hits	153	Shared Neighborhood Hits	140
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

PSG9_HUMAN
NC score	0.403898 (rank : 188)	θ value	6.43352e-06 (rank : 221)
Query Neighborhood Hits	583	Target Neighborhood Hits	221	Shared Neighborhood Hits	198
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

LRFN4_HUMAN
NC score	0.401807 (rank : 189)	θ value	4.0297e-08 (rank : 174)
Query Neighborhood Hits	583	Target Neighborhood Hits	462	Shared Neighborhood Hits	220
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

PSG5_HUMAN
NC score	0.401435 (rank : 190)	θ value	4.92598e-06 (rank : 219)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	204
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

VGFR2_HUMAN
NC score	0.401325 (rank : 191)	θ value	2.61198e-07 (rank : 192)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	337
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

MYLK_HUMAN
NC score	0.399387 (rank : 192)	θ value	9.87957e-23 (rank : 63)
Query Neighborhood Hits	583	Target Neighborhood Hits	1328	Shared Neighborhood Hits	371
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

IL6RB_MOUSE
NC score	0.398553 (rank : 193)	θ value	1.43324e-05 (rank : 228)
Query Neighborhood Hits	583	Target Neighborhood Hits	168	Shared Neighborhood Hits	129
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

VGFR2_MOUSE
NC score	0.397554 (rank : 194)	θ value	2.36244e-08 (rank : 170)
Query Neighborhood Hits	583	Target Neighborhood Hits	1089	Shared Neighborhood Hits	329
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

LRFN4_MOUSE
NC score	0.397459 (rank : 195)	θ value	1.06045e-08 (rank : 161)
Query Neighborhood Hits	583	Target Neighborhood Hits	442	Shared Neighborhood Hits	213
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MYLK_MOUSE
NC score	0.397032 (rank : 196)	θ value	3.39556e-23 (rank : 61)
Query Neighborhood Hits	583	Target Neighborhood Hits	1489	Shared Neighborhood Hits	392
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SPEG_MOUSE
NC score	0.396758 (rank : 197)	θ value	7.30988e-26 (rank : 55)
Query Neighborhood Hits	583	Target Neighborhood Hits	1959	Shared Neighborhood Hits	398
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ITB4_HUMAN
NC score	0.395549 (rank : 198)	θ value	2.13673e-09 (rank : 149)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	163
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

SPEG_HUMAN
NC score	0.392243 (rank : 199)	θ value	2.12685e-25 (rank : 57)
Query Neighborhood Hits	583	Target Neighborhood Hits	1762	Shared Neighborhood Hits	370
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CILP2_HUMAN
NC score	0.389957 (rank : 200)	θ value	3.19293e-05 (rank : 236)
Query Neighborhood Hits	583	Target Neighborhood Hits	307	Shared Neighborhood Hits	192
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LRFN2_HUMAN
NC score	0.389069 (rank : 201)	θ value	6.43352e-06 (rank : 220)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	219
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_MOUSE
NC score	0.388735 (rank : 202)	θ value	4.92598e-06 (rank : 217)
Query Neighborhood Hits	583	Target Neighborhood Hits	450	Shared Neighborhood Hits	224
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

PTPRM_HUMAN
NC score	0.385403 (rank : 203)	θ value	1.52774e-15 (rank : 96)
Query Neighborhood Hits	583	Target Neighborhood Hits	244	Shared Neighborhood Hits	167
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

LRFN3_MOUSE
NC score	0.384862 (rank : 204)	θ value	0.000461057 (rank : 273)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CD276_HUMAN
NC score	0.384022 (rank : 205)	θ value	1.29631e-06 (rank : 205)
Query Neighborhood Hits	583	Target Neighborhood Hits	261	Shared Neighborhood Hits	177
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

LIFR_HUMAN
NC score	0.383784 (rank : 206)	θ value	0.00102713 (rank : 281)
Query Neighborhood Hits	583	Target Neighborhood Hits	130	Shared Neighborhood Hits	96
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

PTPRM_MOUSE
NC score	0.380632 (rank : 207)	θ value	6.41864e-14 (rank : 104)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	164
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

LIFR_MOUSE
NC score	0.373846 (rank : 208)	θ value	0.00228821 (rank : 295)
Query Neighborhood Hits	583	Target Neighborhood Hits	127	Shared Neighborhood Hits	95
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

COEA1_MOUSE
NC score	0.372236 (rank : 209)	θ value	1.133e-10 (rank : 135)
Query Neighborhood Hits	583	Target Neighborhood Hits	402	Shared Neighborhood Hits	121
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

SIGL5_HUMAN
NC score	0.368648 (rank : 210)	θ value	0.163984 (rank : 382)
Query Neighborhood Hits	583	Target Neighborhood Hits	246	Shared Neighborhood Hits	200
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

FGFR4_MOUSE
NC score	0.368417 (rank : 211)	θ value	4.30538e-10 (rank : 142)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	305
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LRFN3_HUMAN
NC score	0.367560 (rank : 212)	θ value	1.43324e-05 (rank : 230)
Query Neighborhood Hits	583	Target Neighborhood Hits	444	Shared Neighborhood Hits	208
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

ESAM_MOUSE
NC score	0.366518 (rank : 213)	θ value	0.0563607 (rank : 353)
Query Neighborhood Hits	583	Target Neighborhood Hits	222	Shared Neighborhood Hits	179
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

TYRO3_HUMAN
NC score	0.365520 (rank : 214)	θ value	8.65492e-19 (rank : 80)
Query Neighborhood Hits	583	Target Neighborhood Hits	995	Shared Neighborhood Hits	286
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

CXAR_HUMAN
NC score	0.365435 (rank : 215)	θ value	1.06291 (rank : 435)
Query Neighborhood Hits	583	Target Neighborhood Hits	245	Shared Neighborhood Hits	181
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

LRFN5_MOUSE
NC score	0.364123 (rank : 216)	θ value	0.000158464 (rank : 258)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	228
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

TYRO3_MOUSE
NC score	0.363466 (rank : 217)	θ value	1.13037e-18 (rank : 81)
Query Neighborhood Hits	583	Target Neighborhood Hits	1007	Shared Neighborhood Hits	295
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

I12R2_MOUSE
NC score	0.361615 (rank : 218)	θ value	0.00175202 (rank : 290)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	116
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

FGFR3_MOUSE
NC score	0.361576 (rank : 219)	θ value	7.58209e-15 (rank : 98)
Query Neighborhood Hits	583	Target Neighborhood Hits	1059	Shared Neighborhood Hits	307
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
NC score	0.361556 (rank : 220)	θ value	1.25267e-09 (rank : 144)
Query Neighborhood Hits	583	Target Neighborhood Hits	1037	Shared Neighborhood Hits	303
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

LRC21_MOUSE
NC score	0.358934 (rank : 221)	θ value	1.06291 (rank : 440)
Query Neighborhood Hits	583	Target Neighborhood Hits	462	Shared Neighborhood Hits	238
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRFN5_HUMAN
NC score	0.357056 (rank : 222)	θ value	0.000270298 (rank : 267)
Query Neighborhood Hits	583	Target Neighborhood Hits	464	Shared Neighborhood Hits	224
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PTPRT_MOUSE
NC score	0.356081 (rank : 223)	θ value	1.63225e-17 (rank : 85)
Query Neighborhood Hits	583	Target Neighborhood Hits	219	Shared Neighborhood Hits	142
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

SIGL8_HUMAN
NC score	0.355508 (rank : 224)	θ value	0.0330416 (rank : 344)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	221
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

PTPRT_HUMAN
NC score	0.354913 (rank : 225)	θ value	4.74913e-17 (rank : 87)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	141
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

FGFR1_HUMAN
NC score	0.354065 (rank : 226)	θ value	1.06045e-08 (rank : 157)
Query Neighborhood Hits	583	Target Neighborhood Hits	1069	Shared Neighborhood Hits	305
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

I12R2_HUMAN
NC score	0.353848 (rank : 227)	θ value	0.163984 (rank : 379)
Query Neighborhood Hits	583	Target Neighborhood Hits	163	Shared Neighborhood Hits	114
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LRC21_HUMAN
NC score	0.353801 (rank : 228)	θ value	0.21417 (rank : 389)
Query Neighborhood Hits	583	Target Neighborhood Hits	456	Shared Neighborhood Hits	234
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

FGFR1_MOUSE
NC score	0.353524 (rank : 229)	θ value	1.06045e-08 (rank : 158)
Query Neighborhood Hits	583	Target Neighborhood Hits	1068	Shared Neighborhood Hits	304
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

CXAR_MOUSE
NC score	0.353028 (rank : 230)	θ value	4.03905 (rank : 503)
Query Neighborhood Hits	583	Target Neighborhood Hits	250	Shared Neighborhood Hits	184
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

TENN_MOUSE
NC score	0.352613 (rank : 231)	θ value	5.08577e-11 (rank : 128)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	155
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

FGFR3_HUMAN
NC score	0.350931 (rank : 232)	θ value	1.29331e-14 (rank : 99)
Query Neighborhood Hits	583	Target Neighborhood Hits	1042	Shared Neighborhood Hits	298
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TENR_HUMAN
NC score	0.346691 (rank : 233)	θ value	2.28291e-11 (rank : 124)
Query Neighborhood Hits	583	Target Neighborhood Hits	526	Shared Neighborhood Hits	168
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

NRG1_HUMAN
NC score	0.346531 (rank : 234)	θ value	1.81305 (rank : 470)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	164
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

VGFR3_HUMAN
NC score	0.345883 (rank : 235)	θ value	1.53129e-07 (rank : 189)
Query Neighborhood Hits	583	Target Neighborhood Hits	1037	Shared Neighborhood Hits	299
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
NC score	0.344450 (rank : 236)	θ value	8.97725e-08 (rank : 183)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	312
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR2_HUMAN
NC score	0.343184 (rank : 237)	θ value	2.13673e-09 (rank : 146)
Query Neighborhood Hits	583	Target Neighborhood Hits	1062	Shared Neighborhood Hits	295
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

SIG12_HUMAN
NC score	0.342181 (rank : 238)	θ value	0.0148317 (rank : 322)
Query Neighborhood Hits	583	Target Neighborhood Hits	245	Shared Neighborhood Hits	222
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

IRPL2_HUMAN
NC score	0.341911 (rank : 239)	θ value	7.1131e-05 (rank : 243)
Query Neighborhood Hits	583	Target Neighborhood Hits	194	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL1_MOUSE
NC score	0.340697 (rank : 240)	θ value	0.00134147 (rank : 285)
Query Neighborhood Hits	583	Target Neighborhood Hits	186	Shared Neighborhood Hits	161
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

IRPL2_MOUSE
NC score	0.338098 (rank : 241)	θ value	0.000121331 (rank : 253)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	149
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

UNC5D_MOUSE
NC score	0.337900 (rank : 242)	θ value	0.0252991 (rank : 334)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	179
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

TENR_MOUSE
NC score	0.337548 (rank : 243)	θ value	6.64225e-11 (rank : 129)
Query Neighborhood Hits	583	Target Neighborhood Hits	531	Shared Neighborhood Hits	165
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

LRRN3_HUMAN
NC score	0.335673 (rank : 244)	θ value	0.000121331 (rank : 255)
Query Neighborhood Hits	583	Target Neighborhood Hits	461	Shared Neighborhood Hits	225
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PVRL3_MOUSE
NC score	0.334747 (rank : 245)	θ value	0.0148317 (rank : 321)
Query Neighborhood Hits	583	Target Neighborhood Hits	212	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

SIGL6_HUMAN
NC score	0.333568 (rank : 246)	θ value	0.813845 (rank : 432)
Query Neighborhood Hits	583	Target Neighborhood Hits	233	Shared Neighborhood Hits	206
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

LRRN1_HUMAN
NC score	0.332803 (rank : 247)	θ value	0.00175202 (rank : 291)
Query Neighborhood Hits	583	Target Neighborhood Hits	518	Shared Neighborhood Hits	260
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

FGFR2_MOUSE
NC score	0.332586 (rank : 248)	θ value	8.97725e-08 (rank : 180)
Query Neighborhood Hits	583	Target Neighborhood Hits	1062	Shared Neighborhood Hits	295
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PTPRU_HUMAN
NC score	0.331896 (rank : 249)	θ value	2.88788e-06 (rank : 213)
Query Neighborhood Hits	583	Target Neighborhood Hits	237	Shared Neighborhood Hits	160
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

IRPL1_HUMAN
NC score	0.330755 (rank : 250)	θ value	0.00228821 (rank : 294)
Query Neighborhood Hits	583	Target Neighborhood Hits	196	Shared Neighborhood Hits	165
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

UNC5D_HUMAN
NC score	0.330306 (rank : 251)	θ value	0.0193708 (rank : 331)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

IL1R2_MOUSE
NC score	0.330024 (rank : 252)	θ value	0.0193708 (rank : 327)
Query Neighborhood Hits	583	Target Neighborhood Hits	125	Shared Neighborhood Hits	108
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

MERTK_HUMAN
NC score	0.323785 (rank : 253)	θ value	1.47974e-10 (rank : 137)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	276
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

CSF3R_HUMAN
NC score	0.323551 (rank : 254)	θ value	0.000121331 (rank : 250)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	104
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

COEA1_HUMAN
NC score	0.323462 (rank : 255)	θ value	3.41135e-07 (rank : 193)
Query Neighborhood Hits	583	Target Neighborhood Hits	427	Shared Neighborhood Hits	132
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

PVRL1_HUMAN
NC score	0.322230 (rank : 256)	θ value	0.00228821 (rank : 297)
Query Neighborhood Hits	583	Target Neighborhood Hits	219	Shared Neighborhood Hits	168
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

LRRN1_MOUSE
NC score	0.321941 (rank : 257)	θ value	0.00509761 (rank : 307)
Query Neighborhood Hits	583	Target Neighborhood Hits	508	Shared Neighborhood Hits	256
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

KALM_HUMAN
NC score	0.321774 (rank : 258)	θ value	0.125558 (rank : 374)
Query Neighborhood Hits	583	Target Neighborhood Hits	114	Shared Neighborhood Hits	79
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

CILP1_MOUSE
NC score	0.321526 (rank : 259)	θ value	3.0926 (rank : 492)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	190
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PTPRK_MOUSE
NC score	0.321008 (rank : 260)	θ value	1.80886e-08 (rank : 167)
Query Neighborhood Hits	583	Target Neighborhood Hits	223	Shared Neighborhood Hits	143
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

MERTK_MOUSE
NC score	0.319286 (rank : 261)	θ value	9.26847e-13 (rank : 109)
Query Neighborhood Hits	583	Target Neighborhood Hits	974	Shared Neighborhood Hits	267
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PVRL3_HUMAN
NC score	0.317617 (rank : 262)	θ value	0.0113563 (rank : 318)
Query Neighborhood Hits	583	Target Neighborhood Hits	204	Shared Neighborhood Hits	164
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PTPRK_HUMAN
NC score	0.317599 (rank : 263)	θ value	1.80886e-08 (rank : 166)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	144
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

MOX2R_MOUSE
NC score	0.317513 (rank : 264)	θ value	0.0113563 (rank : 316)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	103
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

TENN_HUMAN
NC score	0.316538 (rank : 265)	θ value	8.67504e-11 (rank : 133)
Query Neighborhood Hits	583	Target Neighborhood Hits	453	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

CEAM7_HUMAN
NC score	0.315915 (rank : 266)	θ value	0.00509761 (rank : 305)
Query Neighborhood Hits	583	Target Neighborhood Hits	170	Shared Neighborhood Hits	140
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

PECA1_HUMAN
NC score	0.315912 (rank : 267)	θ value	0.47712 (rank : 412)
Query Neighborhood Hits	583	Target Neighborhood Hits	178	Shared Neighborhood Hits	149
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

LRRN3_MOUSE
NC score	0.315327 (rank : 268)	θ value	0.0148317 (rank : 320)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	220
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LRRN5_HUMAN
NC score	0.312705 (rank : 269)	θ value	1.87187e-05 (rank : 233)
Query Neighborhood Hits	583	Target Neighborhood Hits	493	Shared Neighborhood Hits	238
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

HCFC2_MOUSE
NC score	0.311485 (rank : 270)	θ value	0.0961366 (rank : 363)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

UFO_MOUSE
NC score	0.310333 (rank : 271)	θ value	1.06045e-08 (rank : 162)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	260
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

COKA1_HUMAN
NC score	0.310079 (rank : 272)	θ value	1.80886e-08 (rank : 164)
Query Neighborhood Hits	583	Target Neighborhood Hits	403	Shared Neighborhood Hits	121
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CSF1R_MOUSE
NC score	0.309986 (rank : 273)	θ value	0.000786445 (rank : 275)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	254
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ROR2_MOUSE
NC score	0.309760 (rank : 274)	θ value	2.36244e-08 (rank : 169)
Query Neighborhood Hits	583	Target Neighborhood Hits	1000	Shared Neighborhood Hits	263
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

CD276_MOUSE
NC score	0.306906 (rank : 275)	θ value	4.03905 (rank : 501)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	182
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CO7A1_HUMAN
NC score	0.306150 (rank : 276)	θ value	2.0648e-12 (rank : 114)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	173
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

UFO_HUMAN
NC score	0.305196 (rank : 277)	θ value	1.33837e-11 (rank : 123)
Query Neighborhood Hits	583	Target Neighborhood Hits	981	Shared Neighborhood Hits	260
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

CILP1_HUMAN
NC score	0.300337 (rank : 278)	θ value	0.813845 (rank : 427)
Query Neighborhood Hits	583	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ROR2_HUMAN
NC score	0.299855 (rank : 279)	θ value	8.11959e-09 (rank : 155)
Query Neighborhood Hits	583	Target Neighborhood Hits	1014	Shared Neighborhood Hits	260
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

NTRK3_HUMAN
NC score	0.296858 (rank : 280)	θ value	5.26297e-08 (rank : 178)
Query Neighborhood Hits	583	Target Neighborhood Hits	1115	Shared Neighborhood Hits	256
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PIGR_MOUSE
NC score	0.296108 (rank : 281)	θ value	0.62314 (rank : 422)
Query Neighborhood Hits	583	Target Neighborhood Hits	214	Shared Neighborhood Hits	154
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

NTRK2_HUMAN
NC score	0.293182 (rank : 282)	θ value	1.53129e-07 (rank : 187)
Query Neighborhood Hits	583	Target Neighborhood Hits	1081	Shared Neighborhood Hits	264
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.292440 (rank : 283)	θ value	4.45536e-07 (rank : 196)
Query Neighborhood Hits	583	Target Neighborhood Hits	1088	Shared Neighborhood Hits	262
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

PDL1_HUMAN
NC score	0.291853 (rank : 284)	θ value	5.27518 (rank : 532)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PVRL1_MOUSE
NC score	0.290986 (rank : 285)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	583	Target Neighborhood Hits	201	Shared Neighborhood Hits	157
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

IL1R1_HUMAN
NC score	0.289662 (rank : 286)	θ value	0.0193708 (rank : 326)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	123
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

ROR1_HUMAN
NC score	0.285564 (rank : 287)	θ value	5.81887e-07 (rank : 200)
Query Neighborhood Hits	583	Target Neighborhood Hits	1018	Shared Neighborhood Hits	259
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

PGFRA_HUMAN
NC score	0.284850 (rank : 288)	θ value	1.09739e-05 (rank : 225)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	243
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ROR1_MOUSE
NC score	0.283146 (rank : 289)	θ value	2.88788e-06 (rank : 214)
Query Neighborhood Hits	583	Target Neighborhood Hits	1025	Shared Neighborhood Hits	261
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

PGFRA_MOUSE
NC score	0.283039 (rank : 290)	θ value	4.92598e-06 (rank : 218)
Query Neighborhood Hits	583	Target Neighborhood Hits	975	Shared Neighborhood Hits	244
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

LRC24_HUMAN
NC score	0.281275 (rank : 291)	θ value	0.0736092 (rank : 361)
Query Neighborhood Hits	583	Target Neighborhood Hits	404	Shared Neighborhood Hits	189
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

EMB_MOUSE
NC score	0.280855 (rank : 292)	θ value	0.00509761 (rank : 306)
Query Neighborhood Hits	583	Target Neighborhood Hits	83	Shared Neighborhood Hits	80
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

DUET_HUMAN
NC score	0.278610 (rank : 293)	θ value	2.0648e-12 (rank : 115)
Query Neighborhood Hits	583	Target Neighborhood Hits	1220	Shared Neighborhood Hits	294
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

PGFRB_MOUSE
NC score	0.276580 (rank : 294)	θ value	3.19293e-05 (rank : 238)
Query Neighborhood Hits	583	Target Neighborhood Hits	960	Shared Neighborhood Hits	228
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

TARSH_HUMAN
NC score	0.273833 (rank : 295)	θ value	1.43324e-05 (rank : 232)
Query Neighborhood Hits	583	Target Neighborhood Hits	768	Shared Neighborhood Hits	167
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

IL1R1_MOUSE
NC score	0.273315 (rank : 296)	θ value	0.47712 (rank : 409)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	125
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

UNC5A_HUMAN
NC score	0.272670 (rank : 297)	θ value	0.0961366 (rank : 372)
Query Neighborhood Hits	583	Target Neighborhood Hits	198	Shared Neighborhood Hits	121
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ILRL2_MOUSE
NC score	0.272511 (rank : 298)	θ value	1.81305 (rank : 466)
Query Neighborhood Hits	583	Target Neighborhood Hits	158	Shared Neighborhood Hits	144
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

PGFRL_HUMAN
NC score	0.272481 (rank : 299)	θ value	0.813845 (rank : 429)
Query Neighborhood Hits	583	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

UNC5C_MOUSE
NC score	0.270120 (rank : 300)	θ value	0.0193708 (rank : 330)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	129
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.269399 (rank : 301)	θ value	0.00665767 (rank : 313)
Query Neighborhood Hits	583	Target Neighborhood Hits	226	Shared Neighborhood Hits	125
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

KIT_MOUSE
NC score	0.268335 (rank : 302)	θ value	0.21417 (rank : 388)
Query Neighborhood Hits	583	Target Neighborhood Hits	949	Shared Neighborhood Hits	229
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PIGR_HUMAN
NC score	0.268098 (rank : 303)	θ value	0.813845 (rank : 430)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	115
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

TIE1_MOUSE
NC score	0.267998 (rank : 304)	θ value	0.000270298 (rank : 269)
Query Neighborhood Hits	583	Target Neighborhood Hits	1266	Shared Neighborhood Hits	237
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TENA_HUMAN
NC score	0.267864 (rank : 305)	θ value	3.08544e-08 (rank : 172)
Query Neighborhood Hits	583	Target Neighborhood Hits	631	Shared Neighborhood Hits	161
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENX_HUMAN
NC score	0.267365 (rank : 306)	θ value	1.38499e-08 (rank : 163)
Query Neighborhood Hits	583	Target Neighborhood Hits	789	Shared Neighborhood Hits	168
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

NGL1_MOUSE
NC score	0.265235 (rank : 307)	θ value	0.00298849 (rank : 301)
Query Neighborhood Hits	583	Target Neighborhood Hits	512	Shared Neighborhood Hits	230
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.264994 (rank : 308)	θ value	0.00228821 (rank : 296)
Query Neighborhood Hits	583	Target Neighborhood Hits	511	Shared Neighborhood Hits	230
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

LRC4B_MOUSE
NC score	0.264037 (rank : 309)	θ value	0.000461057 (rank : 272)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	218
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

PGFRB_HUMAN
NC score	0.263940 (rank : 310)	θ value	0.0193708 (rank : 329)
Query Neighborhood Hits	583	Target Neighborhood Hits	962	Shared Neighborhood Hits	234
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

IGS21_HUMAN
NC score	0.263353 (rank : 311)	θ value	0.62314 (rank : 420)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	108
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

PTPRB_HUMAN
NC score	0.262822 (rank : 312)	θ value	1.47974e-10 (rank : 138)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	111
SwissProt Accessions	P23467	Gene names	PTPRB, PTPB
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase beta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase beta) (R-PTP-beta).

IGS21_MOUSE
NC score	0.262752 (rank : 313)	θ value	0.365318 (rank : 401)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

LRC4B_HUMAN
NC score	0.261045 (rank : 314)	θ value	0.000461057 (rank : 271)
Query Neighborhood Hits	583	Target Neighborhood Hits	479	Shared Neighborhood Hits	216
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

ILRL1_HUMAN
NC score	0.260810 (rank : 315)	θ value	9.29e-05 (rank : 248)
Query Neighborhood Hits	583	Target Neighborhood Hits	167	Shared Neighborhood Hits	133
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

SORL_HUMAN
NC score	0.260286 (rank : 316)	θ value	1.47974e-10 (rank : 139)
Query Neighborhood Hits	583	Target Neighborhood Hits	440	Shared Neighborhood Hits	133
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

TIE1_HUMAN
NC score	0.259665 (rank : 317)	θ value	1.29631e-06 (rank : 208)
Query Neighborhood Hits	583	Target Neighborhood Hits	1241	Shared Neighborhood Hits	223
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

UNC5B_HUMAN
NC score	0.258652 (rank : 318)	θ value	0.0431538 (rank : 350)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

PVR_HUMAN
NC score	0.256676 (rank : 319)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	139
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

EPHB6_HUMAN
NC score	0.256504 (rank : 320)	θ value	0.000461057 (rank : 270)
Query Neighborhood Hits	583	Target Neighborhood Hits	912	Shared Neighborhood Hits	193
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

LRC24_MOUSE
NC score	0.255810 (rank : 321)	θ value	0.21417 (rank : 390)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	186
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

CSF1R_HUMAN
NC score	0.255770 (rank : 322)	θ value	0.21417 (rank : 383)
Query Neighborhood Hits	583	Target Neighborhood Hits	943	Shared Neighborhood Hits	215
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TIE2_MOUSE
NC score	0.254739 (rank : 323)	θ value	8.67504e-11 (rank : 134)
Query Neighborhood Hits	583	Target Neighborhood Hits	1204	Shared Neighborhood Hits	202
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

KIT_HUMAN
NC score	0.253889 (rank : 324)	θ value	1.06291 (rank : 438)
Query Neighborhood Hits	583	Target Neighborhood Hits	953	Shared Neighborhood Hits	219
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

UNC5B_MOUSE
NC score	0.253756 (rank : 325)	θ value	0.0431538 (rank : 351)
Query Neighborhood Hits	583	Target Neighborhood Hits	226	Shared Neighborhood Hits	132
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

TIE2_HUMAN
NC score	0.253506 (rank : 326)	θ value	2.0648e-12 (rank : 116)
Query Neighborhood Hits	583	Target Neighborhood Hits	1192	Shared Neighborhood Hits	201
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

SORL_MOUSE
NC score	0.252678 (rank : 327)	θ value	4.0297e-08 (rank : 176)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	132
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

CSF3R_MOUSE
NC score	0.251861 (rank : 328)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	583	Target Neighborhood Hits	104	Shared Neighborhood Hits	82
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

PVRL2_MOUSE
NC score	0.251054 (rank : 329)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	143
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

SIGL7_HUMAN
NC score	0.250169 (rank : 330)	θ value	1.06291 (rank : 445)
Query Neighborhood Hits	583	Target Neighborhood Hits	180	Shared Neighborhood Hits	160
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

TENA_MOUSE
NC score	0.250020 (rank : 331)	θ value	1.09739e-05 (rank : 226)
Query Neighborhood Hits	583	Target Neighborhood Hits	596	Shared Neighborhood Hits	146
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

EPHB6_MOUSE
NC score	0.249492 (rank : 332)	θ value	0.00134147 (rank : 284)
Query Neighborhood Hits	583	Target Neighborhood Hits	906	Shared Neighborhood Hits	182
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHA7_HUMAN
NC score	0.246201 (rank : 333)	θ value	1.06045e-08 (rank : 156)
Query Neighborhood Hits	583	Target Neighborhood Hits	1053	Shared Neighborhood Hits	195
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.244100 (rank : 334)	θ value	3.08544e-08 (rank : 171)
Query Neighborhood Hits	583	Target Neighborhood Hits	1025	Shared Neighborhood Hits	194
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

ROS_HUMAN
NC score	0.243724 (rank : 335)	θ value	3.41135e-07 (rank : 194)
Query Neighborhood Hits	583	Target Neighborhood Hits	907	Shared Neighborhood Hits	193
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHB3_MOUSE
NC score	0.242215 (rank : 336)	θ value	0.000158464 (rank : 257)
Query Neighborhood Hits	583	Target Neighborhood Hits	996	Shared Neighborhood Hits	191
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

OX2G_MOUSE
NC score	0.241775 (rank : 337)	θ value	0.00134147 (rank : 287)
Query Neighborhood Hits	583	Target Neighborhood Hits	105	Shared Neighborhood Hits	89
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

EPHA8_MOUSE
NC score	0.240821 (rank : 338)	θ value	0.00665767 (rank : 311)
Query Neighborhood Hits	583	Target Neighborhood Hits	969	Shared Neighborhood Hits	195
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

JAML1_MOUSE
NC score	0.240349 (rank : 339)	θ value	0.0330416 (rank : 339)
Query Neighborhood Hits	583	Target Neighborhood Hits	185	Shared Neighborhood Hits	137
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

EPHB3_HUMAN
NC score	0.240298 (rank : 340)	θ value	5.44631e-05 (rank : 241)
Query Neighborhood Hits	583	Target Neighborhood Hits	996	Shared Neighborhood Hits	190
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

LAG3_MOUSE
NC score	0.240153 (rank : 341)	θ value	0.000121331 (rank : 254)
Query Neighborhood Hits	583	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

UNC5A_MOUSE
NC score	0.239803 (rank : 342)	θ value	0.47712 (rank : 414)
Query Neighborhood Hits	583	Target Neighborhood Hits	203	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

EPHA3_MOUSE
NC score	0.239719 (rank : 343)	θ value	3.77169e-06 (rank : 216)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	198
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA8_HUMAN
NC score	0.237840 (rank : 344)	θ value	0.00665767 (rank : 310)
Query Neighborhood Hits	583	Target Neighborhood Hits	956	Shared Neighborhood Hits	192
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

PGFRL_MOUSE
NC score	0.237330 (rank : 345)	θ value	1.81305 (rank : 471)
Query Neighborhood Hits	583	Target Neighborhood Hits	106	Shared Neighborhood Hits	98
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PDL1_MOUSE
NC score	0.237066 (rank : 346)	θ value	4.03905 (rank : 511)
Query Neighborhood Hits	583	Target Neighborhood Hits	168	Shared Neighborhood Hits	136
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

EPHA4_MOUSE
NC score	0.236826 (rank : 347)	θ value	7.1131e-05 (rank : 242)
Query Neighborhood Hits	583	Target Neighborhood Hits	982	Shared Neighborhood Hits	188
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA3_HUMAN
NC score	0.235217 (rank : 348)	θ value	1.09739e-05 (rank : 224)
Query Neighborhood Hits	583	Target Neighborhood Hits	1005	Shared Neighborhood Hits	196
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHB4_MOUSE
NC score	0.234913 (rank : 349)	θ value	5.26297e-08 (rank : 177)
Query Neighborhood Hits	583	Target Neighborhood Hits	1013	Shared Neighborhood Hits	187
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

LRRC4_HUMAN
NC score	0.234137 (rank : 350)	θ value	0.00390308 (rank : 303)
Query Neighborhood Hits	583	Target Neighborhood Hits	444	Shared Neighborhood Hits	198
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

EPHA4_HUMAN
NC score	0.233840 (rank : 351)	θ value	0.000121331 (rank : 252)
Query Neighborhood Hits	583	Target Neighborhood Hits	975	Shared Neighborhood Hits	185
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

SIG12_MOUSE
NC score	0.233450 (rank : 352)	θ value	0.279714 (rank : 399)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	167
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

PDL2_MOUSE
NC score	0.233141 (rank : 353)	θ value	6.88961 (rank : 550)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PVRL2_HUMAN
NC score	0.232678 (rank : 354)	θ value	8.99809 (rank : 577)
Query Neighborhood Hits	583	Target Neighborhood Hits	185	Shared Neighborhood Hits	129
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

EPHA5_HUMAN
NC score	0.230741 (rank : 355)	θ value	1.80886e-08 (rank : 165)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	196
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB4_HUMAN
NC score	0.228584 (rank : 356)	θ value	1.29631e-06 (rank : 206)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	193
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PTPRV_MOUSE
NC score	0.226843 (rank : 357)	θ value	0.000270298 (rank : 268)
Query Neighborhood Hits	583	Target Neighborhood Hits	179	Shared Neighborhood Hits	83
SwissProt Accessions	P70289	Gene names	Ptprv, Esp
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase V precursor (EC 3.1.3.48) (Embryonic stem cell protein-tyrosine phosphatase) (ES cell phosphatase).

LAG3_HUMAN
NC score	0.225738 (rank : 358)	θ value	1.69304e-06 (rank : 209)
Query Neighborhood Hits	583	Target Neighborhood Hits	129	Shared Neighborhood Hits	85
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

PTPRJ_HUMAN
NC score	0.224597 (rank : 359)	θ value	0.000461057 (rank : 274)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	106
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRJ_MOUSE
NC score	0.223861 (rank : 360)	θ value	0.00134147 (rank : 288)
Query Neighborhood Hits	583	Target Neighborhood Hits	188	Shared Neighborhood Hits	97
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PECA1_MOUSE
NC score	0.223576 (rank : 361)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	583	Target Neighborhood Hits	126	Shared Neighborhood Hits	104
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

EPHB2_MOUSE
NC score	0.222038 (rank : 362)	θ value	9.29e-05 (rank : 246)
Query Neighborhood Hits	583	Target Neighborhood Hits	982	Shared Neighborhood Hits	177
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.222023 (rank : 363)	θ value	9.29e-05 (rank : 245)
Query Neighborhood Hits	583	Target Neighborhood Hits	983	Shared Neighborhood Hits	177
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB1_HUMAN
NC score	0.221915 (rank : 364)	θ value	4.1701e-05 (rank : 239)
Query Neighborhood Hits	583	Target Neighborhood Hits	988	Shared Neighborhood Hits	181
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA2_HUMAN
NC score	0.217800 (rank : 365)	θ value	1.43324e-05 (rank : 227)
Query Neighborhood Hits	583	Target Neighborhood Hits	1021	Shared Neighborhood Hits	180
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

OX2G_HUMAN
NC score	0.217466 (rank : 366)	θ value	0.0113563 (rank : 317)
Query Neighborhood Hits	583	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

EPHA6_HUMAN
NC score	0.214408 (rank : 367)	θ value	0.0193708 (rank : 324)
Query Neighborhood Hits	583	Target Neighborhood Hits	959	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA2_MOUSE
NC score	0.211821 (rank : 368)	θ value	0.000121331 (rank : 251)
Query Neighborhood Hits	583	Target Neighborhood Hits	1020	Shared Neighborhood Hits	175
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

NTRK1_HUMAN
NC score	0.208578 (rank : 369)	θ value	0.00020696 (rank : 261)
Query Neighborhood Hits	583	Target Neighborhood Hits	1023	Shared Neighborhood Hits	196
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHAA_HUMAN
NC score	0.207598 (rank : 370)	θ value	0.000270298 (rank : 264)
Query Neighborhood Hits	583	Target Neighborhood Hits	960	Shared Neighborhood Hits	160
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHA5_MOUSE
NC score	0.207450 (rank : 371)	θ value	0.00298849 (rank : 299)
Query Neighborhood Hits	583	Target Neighborhood Hits	950	Shared Neighborhood Hits	184
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

INSRR_HUMAN
NC score	0.207015 (rank : 372)	θ value	2.13673e-09 (rank : 148)
Query Neighborhood Hits	583	Target Neighborhood Hits	950	Shared Neighborhood Hits	146
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.205737 (rank : 373)	θ value	1.17247e-07 (rank : 184)
Query Neighborhood Hits	583	Target Neighborhood Hits	961	Shared Neighborhood Hits	146
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

EPHA6_MOUSE
NC score	0.205142 (rank : 374)	θ value	0.0431538 (rank : 346)
Query Neighborhood Hits	583	Target Neighborhood Hits	946	Shared Neighborhood Hits	162
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ILRL1_MOUSE
NC score	0.204471 (rank : 375)	θ value	0.125558 (rank : 373)
Query Neighborhood Hits	583	Target Neighborhood Hits	172	Shared Neighborhood Hits	133
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

HHLA2_HUMAN
NC score	0.203740 (rank : 376)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	583	Target Neighborhood Hits	140	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HCFC2_HUMAN
NC score	0.203733 (rank : 377)	θ value	0.47712 (rank : 408)
Query Neighborhood Hits	583	Target Neighborhood Hits	154	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

LRRC4_MOUSE
NC score	0.202523 (rank : 378)	θ value	0.0330416 (rank : 340)
Query Neighborhood Hits	583	Target Neighborhood Hits	412	Shared Neighborhood Hits	168
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

CD80_HUMAN
NC score	0.202045 (rank : 379)	θ value	5.27518 (rank : 516)
Query Neighborhood Hits	583	Target Neighborhood Hits	129	Shared Neighborhood Hits	108
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

FCERA_HUMAN
NC score	0.200202 (rank : 380)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	583	Target Neighborhood Hits	150	Shared Neighborhood Hits	117
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FLT3_MOUSE
NC score	0.198907 (rank : 381)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	140
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

INSR_MOUSE
NC score	0.197625 (rank : 382)	θ value	4.1701e-05 (rank : 240)
Query Neighborhood Hits	583	Target Neighborhood Hits	968	Shared Neighborhood Hits	147
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

CD80_MOUSE
NC score	0.195857 (rank : 383)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

IGF1R_HUMAN
NC score	0.195584 (rank : 384)	θ value	1.38821 (rank : 453)
Query Neighborhood Hits	583	Target Neighborhood Hits	977	Shared Neighborhood Hits	149
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
NC score	0.194117 (rank : 385)	θ value	1.81305 (rank : 464)
Query Neighborhood Hits	583	Target Neighborhood Hits	973	Shared Neighborhood Hits	147
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

PTPRO_HUMAN
NC score	0.193386 (rank : 386)	θ value	0.00298849 (rank : 302)
Query Neighborhood Hits	583	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	Q16827, Q13101	Gene names	PTPRO, GLEPP1, PTPU2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase O precursor (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTPase U2) (PTP-U2).

TRIO_HUMAN
NC score	0.193224 (rank : 387)	θ value	7.59969e-07 (rank : 203)
Query Neighborhood Hits	583	Target Neighborhood Hits	1580	Shared Neighborhood Hits	290
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

INSR_HUMAN
NC score	0.192147 (rank : 388)	θ value	0.00102713 (rank : 279)
Query Neighborhood Hits	583	Target Neighborhood Hits	963	Shared Neighborhood Hits	143
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ANKF1_HUMAN
NC score	0.190772 (rank : 389)	θ value	0.00228821 (rank : 292)
Query Neighborhood Hits	583	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

CRLF1_HUMAN
NC score	0.190378 (rank : 390)	θ value	0.279714 (rank : 396)
Query Neighborhood Hits	583	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

FCGR1_HUMAN
NC score	0.189995 (rank : 391)	θ value	1.81305 (rank : 462)
Query Neighborhood Hits	583	Target Neighborhood Hits	145	Shared Neighborhood Hits	106
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

EPHA1_MOUSE
NC score	0.187243 (rank : 392)	θ value	0.21417 (rank : 384)
Query Neighborhood Hits	583	Target Neighborhood Hits	958	Shared Neighborhood Hits	152
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PDL2_HUMAN
NC score	0.185441 (rank : 393)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	583	Target Neighborhood Hits	114	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

CRLF1_MOUSE
NC score	0.182508 (rank : 394)	θ value	0.279714 (rank : 397)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	81
SwissProt Accessions	Q9JM58	Gene names	Crlf1, Crlm3
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (Cytokine receptor-like molecule 3) (CRLM-3) (NR6).

EPHA1_HUMAN
NC score	0.181113 (rank : 395)	θ value	0.62314 (rank : 419)
Query Neighborhood Hits	583	Target Neighborhood Hits	997	Shared Neighborhood Hits	144
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

IL27B_HUMAN
NC score	0.179663 (rank : 396)	θ value	0.21417 (rank : 387)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

CT075_HUMAN
NC score	0.179273 (rank : 397)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	117
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

FLT3_HUMAN
NC score	0.179263 (rank : 398)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	132
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ILRL2_HUMAN
NC score	0.177310 (rank : 399)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	583	Target Neighborhood Hits	112	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

RIMB2_HUMAN
NC score	0.176691 (rank : 400)	θ value	0.00509761 (rank : 308)
Query Neighborhood Hits	583	Target Neighborhood Hits	263	Shared Neighborhood Hits	63
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CD79A_HUMAN
NC score	0.174752 (rank : 401)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	583	Target Neighborhood Hits	102	Shared Neighborhood Hits	66
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

SHPS1_HUMAN
NC score	0.174190 (rank : 402)	θ value	1.06291 (rank : 444)
Query Neighborhood Hits	583	Target Neighborhood Hits	455	Shared Neighborhood Hits	120
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

CD45_HUMAN
NC score	0.168375 (rank : 403)	θ value	0.00228821 (rank : 293)
Query Neighborhood Hits	583	Target Neighborhood Hits	243	Shared Neighborhood Hits	78
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

MFAP3_HUMAN
NC score	0.168367 (rank : 404)	θ value	0.125558 (rank : 375)
Query Neighborhood Hits	583	Target Neighborhood Hits	91	Shared Neighborhood Hits	84
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

ICAM1_MOUSE
NC score	0.167551 (rank : 405)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	583	Target Neighborhood Hits	99	Shared Neighborhood Hits	86
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

RIMB2_MOUSE
NC score	0.164959 (rank : 406)	θ value	0.0330416 (rank : 343)
Query Neighborhood Hits	583	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CD45_MOUSE
NC score	0.164125 (rank : 407)	θ value	0.0736092 (rank : 359)
Query Neighborhood Hits	583	Target Neighborhood Hits	178	Shared Neighborhood Hits	59
SwissProt Accessions	P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1	Gene names	Ptprc, Ly-5
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (Lymphocyte common antigen Ly-5) (CD45 antigen) (T200).

MOX2R_HUMAN
NC score	0.160669 (rank : 408)	θ value	0.163984 (rank : 380)
Query Neighborhood Hits	583	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

I12R1_HUMAN
NC score	0.160457 (rank : 409)	θ value	1.38821 (rank : 452)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

SIRB1_HUMAN
NC score	0.157910 (rank : 410)	θ value	1.38821 (rank : 457)
Query Neighborhood Hits	583	Target Neighborhood Hits	422	Shared Neighborhood Hits	113
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

ICAM3_HUMAN
NC score	0.156309 (rank : 411)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	583	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

RYK_HUMAN
NC score	0.156210 (rank : 412)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	583	Target Neighborhood Hits	701	Shared Neighborhood Hits	85
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

CD4_HUMAN
NC score	0.155617 (rank : 413)	θ value	0.0330416 (rank : 338)
Query Neighborhood Hits	583	Target Neighborhood Hits	122	Shared Neighborhood Hits	66
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

RYK_MOUSE
NC score	0.154368 (rank : 414)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	84
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

FCGR1_MOUSE
NC score	0.152811 (rank : 415)	θ value	5.27518 (rank : 522)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	90
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

MFAP3_MOUSE
NC score	0.151159 (rank : 416)	θ value	0.47712 (rank : 411)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

LTK_HUMAN
NC score	0.151064 (rank : 417)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	91
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
NC score	0.150473 (rank : 418)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	583	Target Neighborhood Hits	770	Shared Neighborhood Hits	89
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

BTNL2_HUMAN
NC score	0.149370 (rank : 419)	θ value	1.38821 (rank : 449)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

ALK_MOUSE
NC score	0.148940 (rank : 420)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	583	Target Neighborhood Hits	811	Shared Neighborhood Hits	96
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ICAM1_HUMAN
NC score	0.147942 (rank : 421)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

ALK_HUMAN
NC score	0.147682 (rank : 422)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	583	Target Neighborhood Hits	795	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

STYK1_MOUSE
NC score	0.146355 (rank : 423)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	87
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

CT075_MOUSE
NC score	0.144068 (rank : 424)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	583	Target Neighborhood Hits	358	Shared Neighborhood Hits	97
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

STYK1_HUMAN
NC score	0.143781 (rank : 425)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	583	Target Neighborhood Hits	786	Shared Neighborhood Hits	88
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

EMB_HUMAN
NC score	0.143683 (rank : 426)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	583	Target Neighborhood Hits	54	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

RET_MOUSE
NC score	0.143209 (rank : 427)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	91
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

DDR1_MOUSE
NC score	0.142639 (rank : 428)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	91
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

RET_HUMAN
NC score	0.142536 (rank : 429)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

DDR1_HUMAN
NC score	0.142529 (rank : 430)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	90
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

HCFC1_MOUSE
NC score	0.141764 (rank : 431)	θ value	0.0252991 (rank : 333)
Query Neighborhood Hits	583	Target Neighborhood Hits	348	Shared Neighborhood Hits	84
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IGSF2_HUMAN
NC score	0.140540 (rank : 432)	θ value	6.88961 (rank : 546)
Query Neighborhood Hits	583	Target Neighborhood Hits	208	Shared Neighborhood Hits	109
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

I11RA_HUMAN
NC score	0.140131 (rank : 433)	θ value	0.00175202 (rank : 289)
Query Neighborhood Hits	583	Target Neighborhood Hits	138	Shared Neighborhood Hits	70
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

I12R1_MOUSE
NC score	0.139852 (rank : 434)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	583	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

DDR2_HUMAN
NC score	0.139409 (rank : 435)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	89
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FPRP_HUMAN
NC score	0.138862 (rank : 436)	θ value	1.06291 (rank : 436)
Query Neighborhood Hits	583	Target Neighborhood Hits	130	Shared Neighborhood Hits	99
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

PTPRG_HUMAN
NC score	0.138852 (rank : 437)	θ value	1.81305 (rank : 473)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	66
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

IL6RA_MOUSE
NC score	0.138697 (rank : 438)	θ value	0.279714 (rank : 398)
Query Neighborhood Hits	583	Target Neighborhood Hits	104	Shared Neighborhood Hits	77
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

DDR2_MOUSE
NC score	0.138057 (rank : 439)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	583	Target Neighborhood Hits	813	Shared Neighborhood Hits	90
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

PTPRG_MOUSE
NC score	0.137624 (rank : 440)	θ value	1.81305 (rank : 474)
Query Neighborhood Hits	583	Target Neighborhood Hits	260	Shared Neighborhood Hits	63
SwissProt Accessions	Q05909	Gene names	Ptprg
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

I27RA_HUMAN
NC score	0.137356 (rank : 441)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	583	Target Neighborhood Hits	60	Shared Neighborhood Hits	44
SwissProt Accessions	Q6UWB1, O60624	Gene names	IL27RA, CRL1, TCCR, WSX1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR) (Protein CRL1).

AATK_MOUSE
NC score	0.135631 (rank : 442)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	105
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

PTPRE_MOUSE
NC score	0.135541 (rank : 443)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	583	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	P49446, Q62134, Q62444, Q64496	Gene names	Ptpre, Ptpe
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

PTPRA_HUMAN
NC score	0.135455 (rank : 444)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	583	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P18433, Q14513, Q7Z2I2, Q96TD9	Gene names	PTPRA, PTPA
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha).

PTPRE_HUMAN
NC score	0.135235 (rank : 445)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	P23469, Q96KQ6	Gene names	PTPRE
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon).

LY9_MOUSE
NC score	0.135123 (rank : 446)	θ value	0.0563607 (rank : 355)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	78
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

TNK1_HUMAN
NC score	0.134754 (rank : 447)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	89
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

ACK1_MOUSE
NC score	0.134708 (rank : 448)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	583	Target Neighborhood Hits	1080	Shared Neighborhood Hits	118
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

PTPRA_MOUSE
NC score	0.134643 (rank : 449)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	21
SwissProt Accessions	P18052, Q61808	Gene names	Ptpra, Lrp, Ptpa
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase alpha precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (LCA- related phosphatase) (PTPTY-28).

AMGO2_HUMAN
NC score	0.134305 (rank : 450)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	583	Target Neighborhood Hits	357	Shared Neighborhood Hits	129
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

I11RB_MOUSE
NC score	0.134175 (rank : 451)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	583	Target Neighborhood Hits	101	Shared Neighborhood Hits	66
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

RON_MOUSE
NC score	0.133501 (rank : 452)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	86
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ACK1_HUMAN
NC score	0.133484 (rank : 453)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	583	Target Neighborhood Hits	1140	Shared Neighborhood Hits	120
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

PTPRZ_HUMAN
NC score	0.133361 (rank : 454)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	583	Target Neighborhood Hits	255	Shared Neighborhood Hits	53
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

MET_MOUSE
NC score	0.133292 (rank : 455)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_HUMAN
NC score	0.133178 (rank : 456)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AATK_HUMAN
NC score	0.132853 (rank : 457)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	583	Target Neighborhood Hits	1243	Shared Neighborhood Hits	124
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

TNK1_MOUSE
NC score	0.132606 (rank : 458)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	583	Target Neighborhood Hits	806	Shared Neighborhood Hits	93
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

BT3A2_HUMAN
NC score	0.132459 (rank : 459)	θ value	1.06291 (rank : 434)
Query Neighborhood Hits	583	Target Neighborhood Hits	158	Shared Neighborhood Hits	108
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

FAK2_HUMAN
NC score	0.132381 (rank : 460)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK1_HUMAN
NC score	0.132022 (rank : 461)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	90
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK2_MOUSE
NC score	0.131759 (rank : 462)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK1_MOUSE
NC score	0.131726 (rank : 463)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	90
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

RON_HUMAN
NC score	0.131470 (rank : 464)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	87
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

JAML1_HUMAN
NC score	0.130748 (rank : 465)	θ value	4.03905 (rank : 508)
Query Neighborhood Hits	583	Target Neighborhood Hits	108	Shared Neighborhood Hits	77
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

ERBB2_HUMAN
NC score	0.130377 (rank : 466)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	113
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_HUMAN
NC score	0.130228 (rank : 467)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	583	Target Neighborhood Hits	918	Shared Neighborhood Hits	90
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_MOUSE
NC score	0.129593 (rank : 468)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	583	Target Neighborhood Hits	918	Shared Neighborhood Hits	99
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TPSNR_MOUSE
NC score	0.129198 (rank : 469)	θ value	5.27518 (rank : 539)
Query Neighborhood Hits	583	Target Neighborhood Hits	336	Shared Neighborhood Hits	115
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

ERBB3_MOUSE
NC score	0.129062 (rank : 470)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	583	Target Neighborhood Hits	898	Shared Neighborhood Hits	88
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
NC score	0.129008 (rank : 471)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	583	Target Neighborhood Hits	910	Shared Neighborhood Hits	98
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EGFR_MOUSE
NC score	0.128018 (rank : 472)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	583	Target Neighborhood Hits	927	Shared Neighborhood Hits	95
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ZAP70_MOUSE
NC score	0.127808 (rank : 473)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	583	Target Neighborhood Hits	905	Shared Neighborhood Hits	89
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EGFR_HUMAN
NC score	0.127488 (rank : 474)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	583	Target Neighborhood Hits	939	Shared Neighborhood Hits	93
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

KSYK_MOUSE
NC score	0.127295 (rank : 475)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	583	Target Neighborhood Hits	944	Shared Neighborhood Hits	95
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.126963 (rank : 476)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	583	Target Neighborhood Hits	901	Shared Neighborhood Hits	87
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FCG2B_HUMAN
NC score	0.126604 (rank : 477)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	78
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

ZAP70_HUMAN
NC score	0.126457 (rank : 478)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	87
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FCG2C_HUMAN
NC score	0.126016 (rank : 479)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	79
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

SRMS_HUMAN
NC score	0.125380 (rank : 480)	θ value	θ > 10 (rank : 1217)
Query Neighborhood Hits	583	Target Neighborhood Hits	946	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FES_HUMAN
NC score	0.124949 (rank : 481)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	583	Target Neighborhood Hits	978	Shared Neighborhood Hits	88
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
NC score	0.124777 (rank : 482)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SRMS_MOUSE
NC score	0.124055 (rank : 483)	θ value	θ > 10 (rank : 1218)
Query Neighborhood Hits	583	Target Neighborhood Hits	964	Shared Neighborhood Hits	88
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

I11RA_MOUSE
NC score	0.123657 (rank : 484)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

MATK_HUMAN
NC score	0.123323 (rank : 485)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	583	Target Neighborhood Hits	954	Shared Neighborhood Hits	88
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

FPRP_MOUSE
NC score	0.123267 (rank : 486)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	583	Target Neighborhood Hits	116	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

CEAMA_MOUSE
NC score	0.122646 (rank : 487)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	583	Target Neighborhood Hits	41	Shared Neighborhood Hits	36
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

MATK_MOUSE
NC score	0.122562 (rank : 488)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	583	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FER_HUMAN
NC score	0.121787 (rank : 489)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	583	Target Neighborhood Hits	1278	Shared Neighborhood Hits	91
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

AMGO3_HUMAN
NC score	0.121496 (rank : 490)	θ value	0.0193708 (rank : 323)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

CD48_MOUSE
NC score	0.121363 (rank : 491)	θ value	3.0926 (rank : 491)
Query Neighborhood Hits	583	Target Neighborhood Hits	96	Shared Neighborhood Hits	63
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

LEPR_HUMAN
NC score	0.121182 (rank : 492)	θ value	0.0961366 (rank : 365)
Query Neighborhood Hits	583	Target Neighborhood Hits	112	Shared Neighborhood Hits	69
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

CEAM3_HUMAN
NC score	0.120494 (rank : 493)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	583	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

LEPR_MOUSE
NC score	0.120345 (rank : 494)	θ value	0.0563607 (rank : 354)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	60
SwissProt Accessions	P48356, O35686, O54986, Q61215, Q64309, Q9QWG3, Q9QWV5	Gene names	Lepr, db, Obr
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (B219) (CD295 antigen).

BMX_MOUSE
NC score	0.120286 (rank : 495)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	583	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ABL1_MOUSE
NC score	0.119969 (rank : 496)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	583	Target Neighborhood Hits	1178	Shared Neighborhood Hits	104
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TXK_MOUSE
NC score	0.119526 (rank : 497)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	87
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BMX_HUMAN
NC score	0.119326 (rank : 498)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ABL1_HUMAN
NC score	0.118981 (rank : 499)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	583	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
NC score	0.118816 (rank : 500)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	583	Target Neighborhood Hits	1045	Shared Neighborhood Hits	91
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

HCK_MOUSE
NC score	0.118762 (rank : 501)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	583	Target Neighborhood Hits	1029	Shared Neighborhood Hits	88
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ITK_MOUSE
NC score	0.118539 (rank : 502)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	583	Target Neighborhood Hits	985	Shared Neighborhood Hits	88
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

HCK_HUMAN
NC score	0.118531 (rank : 503)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	583	Target Neighborhood Hits	1035	Shared Neighborhood Hits	89
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TXK_HUMAN
NC score	0.118384 (rank : 504)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	583	Target Neighborhood Hits	971	Shared Neighborhood Hits	88
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BLK_MOUSE
NC score	0.118344 (rank : 505)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	583	Target Neighborhood Hits	992	Shared Neighborhood Hits	89
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_HUMAN
NC score	0.118276 (rank : 506)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	90
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

LCK_HUMAN
NC score	0.118216 (rank : 507)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	583	Target Neighborhood Hits	987	Shared Neighborhood Hits	91
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BTK_MOUSE
NC score	0.118187 (rank : 508)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	583	Target Neighborhood Hits	1017	Shared Neighborhood Hits	90
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PTK6_MOUSE
NC score	0.118160 (rank : 509)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	583	Target Neighborhood Hits	1026	Shared Neighborhood Hits	88
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

FRK_HUMAN
NC score	0.118121 (rank : 510)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCFC1_HUMAN
NC score	0.118065 (rank : 511)	θ value	0.0736092 (rank : 360)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	72
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

TEC_HUMAN
NC score	0.117976 (rank : 512)	θ value	θ > 10 (rank : 1254)
Query Neighborhood Hits	583	Target Neighborhood Hits	1006	Shared Neighborhood Hits	88
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ITK_HUMAN
NC score	0.117917 (rank : 513)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	583	Target Neighborhood Hits	1016	Shared Neighborhood Hits	88
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LCK_MOUSE
NC score	0.117646 (rank : 514)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	583	Target Neighborhood Hits	981	Shared Neighborhood Hits	88
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

TEC_MOUSE
NC score	0.117492 (rank : 515)	θ value	θ > 10 (rank : 1255)
Query Neighborhood Hits	583	Target Neighborhood Hits	1006	Shared Neighborhood Hits	88
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CSK_HUMAN
NC score	0.117274 (rank : 516)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BLK_HUMAN
NC score	0.117125 (rank : 517)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	583	Target Neighborhood Hits	994	Shared Neighborhood Hits	89
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_MOUSE
NC score	0.116416 (rank : 518)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	583	Target Neighborhood Hits	1023	Shared Neighborhood Hits	88
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.116267 (rank : 519)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	583	Target Neighborhood Hits	1022	Shared Neighborhood Hits	88
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

JAK1_HUMAN
NC score	0.116159 (rank : 520)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

FGR_HUMAN
NC score	0.116135 (rank : 521)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	583	Target Neighborhood Hits	1067	Shared Neighborhood Hits	91
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

JAK1_MOUSE
NC score	0.116028 (rank : 522)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

FGR_MOUSE
NC score	0.115960 (rank : 523)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	583	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_MOUSE
NC score	0.115771 (rank : 524)	θ value	θ > 10 (rank : 1213)
Query Neighborhood Hits	583	Target Neighborhood Hits	1033	Shared Neighborhood Hits	89
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_HUMAN
NC score	0.115520 (rank : 525)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	583	Target Neighborhood Hits	1059	Shared Neighborhood Hits	92
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CSK_MOUSE
NC score	0.115490 (rank : 526)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	91
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PTK6_HUMAN
NC score	0.115446 (rank : 527)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	583	Target Neighborhood Hits	1020	Shared Neighborhood Hits	88
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

YES_MOUSE
NC score	0.115419 (rank : 528)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	583	Target Neighborhood Hits	1052	Shared Neighborhood Hits	90
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

JAK3_HUMAN
NC score	0.115219 (rank : 529)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	583	Target Neighborhood Hits	827	Shared Neighborhood Hits	87
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

SRC_HUMAN
NC score	0.115114 (rank : 530)	θ value	θ > 10 (rank : 1212)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	90
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

AMGO3_MOUSE
NC score	0.113896 (rank : 531)	θ value	0.0736092 (rank : 358)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

JAK2_HUMAN
NC score	0.113833 (rank : 532)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.113677 (rank : 533)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

AMGO2_MOUSE
NC score	0.113412 (rank : 534)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	583	Target Neighborhood Hits	329	Shared Neighborhood Hits	101
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

FYN_MOUSE
NC score	0.113389 (rank : 535)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	583	Target Neighborhood Hits	1073	Shared Neighborhood Hits	88
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TYK2_MOUSE
NC score	0.112779 (rank : 536)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

SHPS1_MOUSE
NC score	0.112624 (rank : 537)	θ value	6.88961 (rank : 554)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	107
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

FYN_HUMAN
NC score	0.112526 (rank : 538)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	583	Target Neighborhood Hits	1078	Shared Neighborhood Hits	88
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

TYK2_HUMAN
NC score	0.111894 (rank : 539)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	583	Target Neighborhood Hits	841	Shared Neighborhood Hits	88
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK3_MOUSE
NC score	0.111414 (rank : 540)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	86
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

FCRLA_HUMAN
NC score	0.111362 (rank : 541)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	583	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

BT1A1_MOUSE
NC score	0.111111 (rank : 542)	θ value	0.0431538 (rank : 345)
Query Neighborhood Hits	583	Target Neighborhood Hits	252	Shared Neighborhood Hits	131
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

PTN7_MOUSE
NC score	0.109753 (rank : 543)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	583	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BUM3	Gene names	Ptpn7
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).

PTN9_MOUSE
NC score	0.109730 (rank : 544)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	21
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN7_HUMAN
NC score	0.109678 (rank : 545)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	583	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	P35236, Q9BV05	Gene names	PTPN7
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) (Protein-tyrosine phosphatase LC-PTP) (Hematopoietic protein-tyrosine phosphatase) (HEPTP).

TPSNR_HUMAN
NC score	0.109656 (rank : 546)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	583	Target Neighborhood Hits	330	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

PTN9_HUMAN
NC score	0.109393 (rank : 547)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	583	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

PTN5_MOUSE
NC score	0.109248 (rank : 548)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	P54830, Q64694	Gene names	Ptpn5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN5_HUMAN
NC score	0.109173 (rank : 549)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	583	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	P54829, Q8N2A1	Gene names	PTPN5
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Protein-tyrosine phosphatase striatum-enriched) (STEP) (Neural- specific protein-tyrosine phosphatase).

PTN2_HUMAN
NC score	0.108350 (rank : 550)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	22
SwissProt Accessions	P17706, Q96HR2	Gene names	PTPN2, PTPT
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP).

FCRLA_MOUSE
NC score	0.107960 (rank : 551)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	583	Target Neighborhood Hits	110	Shared Neighborhood Hits	62
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

AMGO1_HUMAN
NC score	0.107693 (rank : 552)	θ value	0.62314 (rank : 416)
Query Neighborhood Hits	583	Target Neighborhood Hits	353	Shared Neighborhood Hits	105
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

PTN2_MOUSE
NC score	0.107572 (rank : 553)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	583	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q06180, Q3V259, Q922E7	Gene names	Ptpn2, Ptpt
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-2) (MPTP).

PTPRN_MOUSE
NC score	0.107526 (rank : 554)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

PTPRR_HUMAN
NC score	0.107180 (rank : 555)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	583	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q15256, O00342, Q92682, Q9UE65	Gene names	PTPRR, ECPTP
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase PCPTP1) (NC-PTPCOM1) (Ch-1PTPase).

PTPRR_MOUSE
NC score	0.106984 (rank : 556)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	583	Target Neighborhood Hits	84	Shared Neighborhood Hits	22
SwissProt Accessions	Q62132, Q64491, Q64492, Q9QUH9	Gene names	Ptprr, Ptp13
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase R precursor (EC 3.1.3.48) (Protein-tyrosine-phosphatase SL) (Phosphotyrosine phosphatase 13).

PTN1_HUMAN
NC score	0.106877 (rank : 557)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	583	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	P18031, Q5TGD8, Q9BQV9, Q9NQQ4	Gene names	PTPN1, PTP1B
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B).

PTN1_MOUSE
NC score	0.106738 (rank : 558)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	P35821, Q60840, Q62131, Q64498, Q99JS1	Gene names	Ptpn1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) (Protein-protein-tyrosine phosphatase HA2) (PTP-HA2).

PTN22_HUMAN
NC score	0.106685 (rank : 559)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTPR2_MOUSE
NC score	0.106566 (rank : 560)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	583	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PTPRN_HUMAN
NC score	0.106491 (rank : 561)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	583	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PTPR2_HUMAN
NC score	0.106336 (rank : 562)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	583	Target Neighborhood Hits	103	Shared Neighborhood Hits	21
SwissProt Accessions	Q92932, Q8N4I5, Q92662	Gene names	PTPRN2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (Islet cell autoantigen-related protein) (ICAAR) (IAR) (Phogrin).

PTN18_MOUSE
NC score	0.106092 (rank : 563)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	583	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q61152, Q4JFH4, Q62404, Q922E3	Gene names	Ptpn18, Flp1, Ptpk1
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Fetal liver phosphatase 1) (FLP-1) (PTP-K1).

IL1AP_MOUSE
NC score	0.105879 (rank : 564)	θ value	0.62314 (rank : 421)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	57
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

SIGL9_HUMAN
NC score	0.104748 (rank : 565)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	583	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

PTN22_MOUSE
NC score	0.104698 (rank : 566)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	583	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN18_HUMAN
NC score	0.104670 (rank : 567)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	583	Target Neighborhood Hits	73	Shared Neighborhood Hits	24
SwissProt Accessions	Q99952	Gene names	PTPN18, BDP1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase).

PTN12_HUMAN
NC score	0.104466 (rank : 568)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	583	Target Neighborhood Hits	102	Shared Neighborhood Hits	22
SwissProt Accessions	Q05209, Q16130, Q59FD6, Q75MN8, Q86XU4	Gene names	PTPN12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase G1) (PTPG1).

PTN12_MOUSE
NC score	0.103933 (rank : 569)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	583	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

GUC2C_HUMAN
NC score	0.103327 (rank : 570)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	583	Target Neighborhood Hits	624	Shared Neighborhood Hits	79
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

FCG2A_HUMAN
NC score	0.103001 (rank : 571)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	583	Target Neighborhood Hits	92	Shared Neighborhood Hits	68
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

SIRPG_HUMAN
NC score	0.102928 (rank : 572)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	583	Target Neighborhood Hits	359	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SIGIR_MOUSE
NC score	0.102916 (rank : 573)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	63
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

M3KL4_HUMAN
NC score	0.102050 (rank : 574)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	583	Target Neighborhood Hits	1087	Shared Neighborhood Hits	93
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MLKL_HUMAN
NC score	0.102036 (rank : 575)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	82
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

GUC2F_HUMAN
NC score	0.101203 (rank : 576)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	583	Target Neighborhood Hits	740	Shared Neighborhood Hits	86
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

LRRK1_MOUSE
NC score	0.100789 (rank : 577)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	583	Target Neighborhood Hits	1267	Shared Neighborhood Hits	124
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MLTK_MOUSE
NC score	0.099729 (rank : 578)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.099539 (rank : 579)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

I18RA_HUMAN
NC score	0.099349 (rank : 580)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	66
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

IL27B_MOUSE
NC score	0.099314 (rank : 581)	θ value	0.0961366 (rank : 364)
Query Neighborhood Hits	583	Target Neighborhood Hits	55	Shared Neighborhood Hits	37
SwissProt Accessions	O35228	Gene names	Ebi3, Il17b
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein homolog).

M3K12_MOUSE
NC score	0.098997 (rank : 582)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	583	Target Neighborhood Hits	957	Shared Neighborhood Hits	95
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	0.098903 (rank : 583)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	583	Target Neighborhood Hits	940	Shared Neighborhood Hits	94
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PTN6_HUMAN
NC score	0.098734 (rank : 584)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	583	Target Neighborhood Hits	234	Shared Neighborhood Hits	23
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

M3K9_HUMAN
NC score	0.098618 (rank : 585)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	583	Target Neighborhood Hits	1123	Shared Neighborhood Hits	106
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

PTN6_MOUSE
NC score	0.098595 (rank : 586)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	583	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

M3K10_HUMAN
NC score	0.098574 (rank : 587)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	583	Target Neighborhood Hits	1071	Shared Neighborhood Hits	95
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

LRRK1_HUMAN
NC score	0.098457 (rank : 588)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	583	Target Neighborhood Hits	1237	Shared Neighborhood Hits	123
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

M3K11_HUMAN
NC score	0.098172 (rank : 589)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	583	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CD226_HUMAN
NC score	0.097594 (rank : 590)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	583	Target Neighborhood Hits	87	Shared Neighborhood Hits	68
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

IL6RA_HUMAN
NC score	0.097151 (rank : 591)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	583	Target Neighborhood Hits	96	Shared Neighborhood Hits	60
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

BTNL1_MOUSE
NC score	0.096850 (rank : 592)	θ value	6.88961 (rank : 542)
Query Neighborhood Hits	583	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

PTN23_MOUSE
NC score	0.096795 (rank : 593)	θ value	6.88961 (rank : 553)
Query Neighborhood Hits	583	Target Neighborhood Hits	726	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

M3K13_HUMAN
NC score	0.096555 (rank : 594)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	89
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

ARAF_MOUSE
NC score	0.096243 (rank : 595)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

PTN11_HUMAN
NC score	0.096167 (rank : 596)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
NC score	0.096146 (rank : 597)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

ARAF_HUMAN
NC score	0.096002 (rank : 598)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	94
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BRAF1_HUMAN
NC score	0.095973 (rank : 599)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	583	Target Neighborhood Hits	883	Shared Neighborhood Hits	91
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

MLKL_MOUSE
NC score	0.095654 (rank : 600)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	583	Target Neighborhood Hits	707	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RAF1_MOUSE
NC score	0.095625 (rank : 601)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

I18RA_MOUSE
NC score	0.095571 (rank : 602)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

RAF1_HUMAN
NC score	0.095069 (rank : 603)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TESK2_HUMAN
NC score	0.094931 (rank : 604)	θ value	θ > 10 (rank : 1258)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	90
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
NC score	0.094797 (rank : 605)	θ value	θ > 10 (rank : 1259)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ILK_MOUSE
NC score	0.094211 (rank : 606)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	90
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

BT1A1_HUMAN
NC score	0.094012 (rank : 607)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	583	Target Neighborhood Hits	322	Shared Neighborhood Hits	127
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

M3K7_MOUSE
NC score	0.093894 (rank : 608)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	90
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.093859 (rank : 609)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	90
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

ILK1_HUMAN
NC score	0.093701 (rank : 610)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	90
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

MOS_HUMAN
NC score	0.093109 (rank : 611)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	88
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CD48_HUMAN
NC score	0.093089 (rank : 612)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

RIPK1_MOUSE
NC score	0.092186 (rank : 613)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

GP116_HUMAN
NC score	0.091733 (rank : 614)	θ value	0.47712 (rank : 407)
Query Neighborhood Hits	583	Target Neighborhood Hits	167	Shared Neighborhood Hits	79
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

RIPK1_HUMAN
NC score	0.091720 (rank : 615)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	583	Target Neighborhood Hits	891	Shared Neighborhood Hits	90
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ILK2_HUMAN
NC score	0.091650 (rank : 616)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	90
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

PTN23_HUMAN
NC score	0.091561 (rank : 617)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	583	Target Neighborhood Hits	646	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

ICOSL_MOUSE
NC score	0.091176 (rank : 618)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

KSR1_HUMAN
NC score	0.090501 (rank : 619)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

TESK1_MOUSE
NC score	0.090330 (rank : 620)	θ value	θ > 10 (rank : 1257)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	96
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

KSR1_MOUSE
NC score	0.090296 (rank : 621)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	583	Target Neighborhood Hits	870	Shared Neighborhood Hits	92
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

AMGO1_MOUSE
NC score	0.089689 (rank : 622)	θ value	1.81305 (rank : 460)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	83
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

RIPK3_HUMAN
NC score	0.089640 (rank : 623)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK2_MOUSE
NC score	0.089497 (rank : 624)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	583	Target Neighborhood Hits	776	Shared Neighborhood Hits	86
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

TESK1_HUMAN
NC score	0.089015 (rank : 625)	θ value	θ > 10 (rank : 1256)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	93
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

MOS_MOUSE
NC score	0.088643 (rank : 626)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	89
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

LIMK1_HUMAN
NC score	0.088556 (rank : 627)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	583	Target Neighborhood Hits	1005	Shared Neighborhood Hits	91
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.088361 (rank : 628)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	583	Target Neighborhood Hits	1008	Shared Neighborhood Hits	92
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
NC score	0.087859 (rank : 629)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	583	Target Neighborhood Hits	986	Shared Neighborhood Hits	90
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
NC score	0.087756 (rank : 630)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	583	Target Neighborhood Hits	998	Shared Neighborhood Hits	90
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

IL1AP_HUMAN
NC score	0.087518 (rank : 631)	θ value	5.27518 (rank : 525)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

GUC2E_MOUSE
NC score	0.087282 (rank : 632)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	583	Target Neighborhood Hits	692	Shared Neighborhood Hits	84
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

IRAK4_HUMAN
NC score	0.086991 (rank : 633)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	583	Target Neighborhood Hits	816	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK3_MOUSE
NC score	0.086869 (rank : 634)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	583	Target Neighborhood Hits	628	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK2_HUMAN
NC score	0.086466 (rank : 635)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	85
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

CD244_HUMAN
NC score	0.086444 (rank : 636)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	583	Target Neighborhood Hits	72	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

LRRK2_HUMAN
NC score	0.085983 (rank : 637)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	583	Target Neighborhood Hits	1382	Shared Neighborhood Hits	117
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

PTN14_HUMAN
NC score	0.085176 (rank : 638)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	583	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

IRAK4_MOUSE
NC score	0.085162 (rank : 639)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	89
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

RIPK5_MOUSE
NC score	0.084192 (rank : 640)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK5_HUMAN
NC score	0.084191 (rank : 641)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	88
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LRRK2_MOUSE
NC score	0.084154 (rank : 642)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	583	Target Neighborhood Hits	1359	Shared Neighborhood Hits	119
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TOPK_MOUSE
NC score	0.084145 (rank : 643)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	583	Target Neighborhood Hits	618	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

PTN14_MOUSE
NC score	0.083989 (rank : 644)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	26
SwissProt Accessions	Q62130	Gene names	Ptpn14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP36).

PTN21_MOUSE
NC score	0.083878 (rank : 645)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	26
SwissProt Accessions	Q62136	Gene names	Ptpn21
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase PTP-RL10).

TEX14_HUMAN
NC score	0.083405 (rank : 646)	θ value	θ > 10 (rank : 1260)
Query Neighborhood Hits	583	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

PTN21_HUMAN
NC score	0.083275 (rank : 647)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	24
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

TEX14_MOUSE
NC score	0.083008 (rank : 648)	θ value	θ > 10 (rank : 1261)
Query Neighborhood Hits	583	Target Neighborhood Hits	1333	Shared Neighborhood Hits	96
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

PTN3_HUMAN
NC score	0.082254 (rank : 649)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	583	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

BT3A3_HUMAN
NC score	0.081815 (rank : 650)	θ value	0.279714 (rank : 395)
Query Neighborhood Hits	583	Target Neighborhood Hits	233	Shared Neighborhood Hits	115
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

GUC2D_HUMAN
NC score	0.081744 (rank : 651)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	86
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

TOPK_HUMAN
NC score	0.081676 (rank : 652)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	583	Target Neighborhood Hits	605	Shared Neighborhood Hits	77
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TMM25_MOUSE
NC score	0.081606 (rank : 653)	θ value	θ > 10 (rank : 1275)
Query Neighborhood Hits	583	Target Neighborhood Hits	46	Shared Neighborhood Hits	42
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

IGSF8_MOUSE
NC score	0.081592 (rank : 654)	θ value	1.81305 (rank : 465)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

IGSF8_HUMAN
NC score	0.081545 (rank : 655)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	583	Target Neighborhood Hits	88	Shared Neighborhood Hits	48
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

GUC2G_MOUSE
NC score	0.081261 (rank : 656)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	583	Target Neighborhood Hits	644	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GP125_MOUSE
NC score	0.081033 (rank : 657)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	583	Target Neighborhood Hits	329	Shared Neighborhood Hits	66
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

KSR2_HUMAN
NC score	0.080805 (rank : 658)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	583	Target Neighborhood Hits	920	Shared Neighborhood Hits	98
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

IRAK3_HUMAN
NC score	0.080619 (rank : 659)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	583	Target Neighborhood Hits	644	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ANPRA_MOUSE
NC score	0.080382 (rank : 660)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	583	Target Neighborhood Hits	600	Shared Neighborhood Hits	81
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.080319 (rank : 661)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	583	Target Neighborhood Hits	612	Shared Neighborhood Hits	81
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

BT3A1_HUMAN
NC score	0.080102 (rank : 662)	θ value	0.813845 (rank : 425)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	108
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

I27RA_MOUSE
NC score	0.080032 (rank : 663)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	583	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	O70394	Gene names	Il27ra, Tccr, Wsx1
Domain Architecture	No domain graphic available
Description	Interleukin-27 receptor alpha chain precursor (IL-27R-alpha) (WSX-1) (Type I T-cell cytokine receptor) (TCCR).

PTN4_HUMAN
NC score	0.079672 (rank : 664)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	30
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

GP125_HUMAN
NC score	0.079291 (rank : 665)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	583	Target Neighborhood Hits	327	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

A1BG_HUMAN
NC score	0.079272 (rank : 666)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	583	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

TNI3K_MOUSE
NC score	0.078461 (rank : 667)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	583	Target Neighborhood Hits	1079	Shared Neighborhood Hits	92
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ACVL1_MOUSE
NC score	0.078244 (rank : 668)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	583	Target Neighborhood Hits	739	Shared Neighborhood Hits	81
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TNI3K_HUMAN
NC score	0.077769 (rank : 669)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	583	Target Neighborhood Hits	1084	Shared Neighborhood Hits	90
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

IRAK1_HUMAN
NC score	0.077608 (rank : 670)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	93
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
NC score	0.077490 (rank : 671)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	583	Target Neighborhood Hits	784	Shared Neighborhood Hits	95
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

FCG3B_HUMAN
NC score	0.076431 (rank : 672)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	583	Target Neighborhood Hits	67	Shared Neighborhood Hits	51
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

PTN13_MOUSE
NC score	0.076408 (rank : 673)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	583	Target Neighborhood Hits	426	Shared Neighborhood Hits	31
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PTN13_HUMAN
NC score	0.075611 (rank : 674)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	583	Target Neighborhood Hits	471	Shared Neighborhood Hits	34
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TRIM9_HUMAN
NC score	0.075381 (rank : 675)	θ value	0.279714 (rank : 400)
Query Neighborhood Hits	583	Target Neighborhood Hits	294	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

ANPRB_HUMAN
NC score	0.075296 (rank : 676)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	583	Target Neighborhood Hits	646	Shared Neighborhood Hits	81
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ACVL1_HUMAN
NC score	0.075002 (rank : 677)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	583	Target Neighborhood Hits	716	Shared Neighborhood Hits	80
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

IKKA_HUMAN
NC score	0.074517 (rank : 678)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	583	Target Neighborhood Hits	863	Shared Neighborhood Hits	88
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

TGFR2_HUMAN
NC score	0.074505 (rank : 679)	θ value	θ > 10 (rank : 1264)
Query Neighborhood Hits	583	Target Neighborhood Hits	748	Shared Neighborhood Hits	85
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

IKKA_MOUSE
NC score	0.074315 (rank : 680)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

ANPRB_MOUSE
NC score	0.074241 (rank : 681)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	583	Target Neighborhood Hits	607	Shared Neighborhood Hits	81
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

CEA19_HUMAN
NC score	0.074104 (rank : 682)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	583	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z692, Q7Z693	Gene names	CEACAM19, CEAL1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 19 precursor (Carcinoembryonic antigen-like 1).

NEK11_MOUSE
NC score	0.073897 (rank : 683)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TGFR2_MOUSE
NC score	0.073513 (rank : 684)	θ value	θ > 10 (rank : 1265)
Query Neighborhood Hits	583	Target Neighborhood Hits	748	Shared Neighborhood Hits	86
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

LY9_HUMAN
NC score	0.072720 (rank : 685)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9HBG7, Q14775, Q5VYI3, Q9H4N5, Q9NQ24	Gene names	LY9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9) (CD229 antigen).

NEK11_HUMAN
NC score	0.072631 (rank : 686)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	583	Target Neighborhood Hits	1043	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK24_MOUSE
NC score	0.072415 (rank : 687)	θ value	θ > 10 (rank : 1229)
Query Neighborhood Hits	583	Target Neighborhood Hits	856	Shared Neighborhood Hits	88
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK24_HUMAN
NC score	0.072390 (rank : 688)	θ value	θ > 10 (rank : 1228)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

ICOSL_HUMAN
NC score	0.072334 (rank : 689)	θ value	5.27518 (rank : 524)
Query Neighborhood Hits	583	Target Neighborhood Hits	70	Shared Neighborhood Hits	54
SwissProt Accessions	O75144, Q9HD18, Q9NRQ1	Gene names	ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD275 antigen).

SLAF8_MOUSE
NC score	0.072259 (rank : 690)	θ value	1.38821 (rank : 458)
Query Neighborhood Hits	583	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D3G2, Q8R3T7	Gene names	Slamf8, Blame
Domain Architecture	No domain graphic available
Description	SLAM family member 8 precursor (B-lymphocyte activator macrophage expressed).

IL18R_MOUSE
NC score	0.072136 (rank : 691)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

NEK7_HUMAN
NC score	0.071877 (rank : 692)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

FLRT3_HUMAN
NC score	0.071795 (rank : 693)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

NEK7_MOUSE
NC score	0.071788 (rank : 694)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MST4_HUMAN
NC score	0.071367 (rank : 695)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	88
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MYLK2_HUMAN
NC score	0.071317 (rank : 696)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	583	Target Neighborhood Hits	920	Shared Neighborhood Hits	91
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

TMM25_HUMAN
NC score	0.071289 (rank : 697)	θ value	θ > 10 (rank : 1274)
Query Neighborhood Hits	583	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

MST4_MOUSE
NC score	0.071254 (rank : 698)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

YSK4_HUMAN
NC score	0.070988 (rank : 699)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	583	Target Neighborhood Hits	921	Shared Neighborhood Hits	91
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

TRI42_HUMAN
NC score	0.070820 (rank : 700)	θ value	0.0961366 (rank : 370)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

SLIT2_HUMAN
NC score	0.070811 (rank : 701)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	583	Target Neighborhood Hits	708	Shared Neighborhood Hits	68
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

VASN_MOUSE
NC score	0.070747 (rank : 702)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	583	Target Neighborhood Hits	426	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

SLAF9_MOUSE
NC score	0.070732 (rank : 703)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D780, Q8BTK0, Q8VE93	Gene names	Slamf9
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor.

RIPK3_MOUSE
NC score	0.070399 (rank : 704)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

NEK6_HUMAN
NC score	0.070355 (rank : 705)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

FLRT1_HUMAN
NC score	0.070220 (rank : 706)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	583	Target Neighborhood Hits	286	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZU1	Gene names	FLRT1
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT1 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 1).

NEK6_MOUSE
NC score	0.070168 (rank : 707)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

SLIT2_MOUSE
NC score	0.069795 (rank : 708)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	583	Target Neighborhood Hits	684	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

FCG3A_HUMAN
NC score	0.069653 (rank : 709)	θ value	4.03905 (rank : 506)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	49
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

TGFR1_MOUSE
NC score	0.069313 (rank : 710)	θ value	θ > 10 (rank : 1263)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	87
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

CNTFR_MOUSE
NC score	0.069268 (rank : 711)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	583	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

VASN_HUMAN
NC score	0.069070 (rank : 712)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	583	Target Neighborhood Hits	449	Shared Neighborhood Hits	62
SwissProt Accessions	Q6EMK4, Q6UXL4, Q6UXL5, Q96CX1	Gene names	VASN, SLITL2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

SLIT1_MOUSE
NC score	0.069035 (rank : 713)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	67
SwissProt Accessions	Q80TR4, Q9WVB5	Gene names	Slit1, Kiaa0813
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1).

CD86_MOUSE
NC score	0.068962 (rank : 714)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	P42082	Gene names	Cd86
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (Early T-cell costimulatory molecule 1) (ETC-1).

NEK4_HUMAN
NC score	0.068957 (rank : 715)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	583	Target Neighborhood Hits	883	Shared Neighborhood Hits	89
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

TGFR1_HUMAN
NC score	0.068951 (rank : 716)	θ value	θ > 10 (rank : 1262)
Query Neighborhood Hits	583	Target Neighborhood Hits	755	Shared Neighborhood Hits	87
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

NEK4_MOUSE
NC score	0.068615 (rank : 717)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

MP2K5_MOUSE
NC score	0.068596 (rank : 718)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

STK25_MOUSE
NC score	0.068517 (rank : 719)	θ value	θ > 10 (rank : 1231)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_HUMAN
NC score	0.068205 (rank : 720)	θ value	θ > 10 (rank : 1230)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

ANKK1_MOUSE
NC score	0.068103 (rank : 721)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	583	Target Neighborhood Hits	1072	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

SLIT3_HUMAN
NC score	0.068004 (rank : 722)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	583	Target Neighborhood Hits	682	Shared Neighborhood Hits	66
SwissProt Accessions	O75094, O95804, Q9UFH5	Gene names	SLIT3, KIAA0814, MEGF5, SLIL2
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Multiple epidermal growth factor-like domains 5).

CD33_HUMAN
NC score	0.067894 (rank : 723)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	583	Target Neighborhood Hits	50	Shared Neighborhood Hits	36
SwissProt Accessions	P20138, Q8TD24	Gene names	CD33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3) (gp67).

E2AK2_HUMAN
NC score	0.067871 (rank : 724)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	583	Target Neighborhood Hits	856	Shared Neighborhood Hits	87
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

BMR1B_MOUSE
NC score	0.067761 (rank : 725)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	583	Target Neighborhood Hits	758	Shared Neighborhood Hits	84
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

MP2K5_HUMAN
NC score	0.067742 (rank : 726)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	89
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

SLIT3_MOUSE
NC score	0.067734 (rank : 727)	θ value	θ > 10 (rank : 1204)
Query Neighborhood Hits	583	Target Neighborhood Hits	700	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVB4	Gene names	Slit3
Domain Architecture
Description	Slit homolog 3 protein precursor (Slit-3) (Slit3).

STK4_MOUSE
NC score	0.067703 (rank : 728)	θ value	θ > 10 (rank : 1241)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

IKKB_HUMAN
NC score	0.067695 (rank : 729)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	583	Target Neighborhood Hits	980	Shared Neighborhood Hits	88
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

STK4_HUMAN
NC score	0.067489 (rank : 730)	θ value	θ > 10 (rank : 1240)
Query Neighborhood Hits	583	Target Neighborhood Hits	870	Shared Neighborhood Hits	89
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

IKKB_MOUSE
NC score	0.067463 (rank : 731)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	583	Target Neighborhood Hits	984	Shared Neighborhood Hits	88
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

SLIT1_HUMAN
NC score	0.067454 (rank : 732)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	583	Target Neighborhood Hits	700	Shared Neighborhood Hits	66
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

ST17B_MOUSE
NC score	0.067320 (rank : 733)	θ value	θ > 10 (rank : 1221)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK3_MOUSE
NC score	0.067271 (rank : 734)	θ value	θ > 10 (rank : 1239)
Query Neighborhood Hits	583	Target Neighborhood Hits	869	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

BMR1A_HUMAN
NC score	0.067211 (rank : 735)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	583	Target Neighborhood Hits	759	Shared Neighborhood Hits	86
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

DAPK3_HUMAN
NC score	0.067126 (rank : 736)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	583	Target Neighborhood Hits	945	Shared Neighborhood Hits	88
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ACV1C_HUMAN
NC score	0.067094 (rank : 737)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	583	Target Neighborhood Hits	709	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

CNTFR_HUMAN
NC score	0.067056 (rank : 738)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	583	Target Neighborhood Hits	66	Shared Neighborhood Hits	39
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

TRIM9_MOUSE
NC score	0.067055 (rank : 739)	θ value	2.36792 (rank : 486)
Query Neighborhood Hits	583	Target Neighborhood Hits	274	Shared Neighborhood Hits	57
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

DAPK2_MOUSE
NC score	0.067049 (rank : 740)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

BMR1A_MOUSE
NC score	0.067005 (rank : 741)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	583	Target Neighborhood Hits	758	Shared Neighborhood Hits	85
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

CD86_HUMAN
NC score	0.066888 (rank : 742)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	P42081, Q13655, Q7M4L5	Gene names	CD86, CD28LG2
Domain Architecture
Description	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63).

DAPK2_HUMAN
NC score	0.066800 (rank : 743)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

STK3_HUMAN
NC score	0.066636 (rank : 744)	θ value	θ > 10 (rank : 1238)
Query Neighborhood Hits	583	Target Neighborhood Hits	861	Shared Neighborhood Hits	89
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

DAPK3_MOUSE
NC score	0.066606 (rank : 745)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

BMR1B_HUMAN
NC score	0.066489 (rank : 746)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	583	Target Neighborhood Hits	760	Shared Neighborhood Hits	84
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

STK33_HUMAN
NC score	0.066375 (rank : 747)	θ value	θ > 10 (rank : 1232)
Query Neighborhood Hits	583	Target Neighborhood Hits	879	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PRLR_MOUSE
NC score	0.066359 (rank : 748)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	583	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q08501, P15212, P15213, Q62099	Gene names	Prlr
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

PRLR_HUMAN
NC score	0.066333 (rank : 749)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	583	Target Neighborhood Hits	95	Shared Neighborhood Hits	46
SwissProt Accessions	P16471, Q16354, Q9BX87	Gene names	PRLR
Domain Architecture
Description	Prolactin receptor precursor (PRL-R).

RIPK4_HUMAN
NC score	0.066240 (rank : 750)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	583	Target Neighborhood Hits	1094	Shared Neighborhood Hits	94
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ACVR1_MOUSE
NC score	0.066213 (rank : 751)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	583	Target Neighborhood Hits	768	Shared Neighborhood Hits	84
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ULK3_MOUSE
NC score	0.065881 (rank : 752)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	88
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

NYX_MOUSE
NC score	0.065687 (rank : 753)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	583	Target Neighborhood Hits	241	Shared Neighborhood Hits	37
SwissProt Accessions	P83503, Q8BYN4	Gene names	Nyx
Domain Architecture
Description	Nyctalopin precursor.

CD2L7_HUMAN
NC score	0.065652 (rank : 754)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	583	Target Neighborhood Hits	1275	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

STK36_MOUSE
NC score	0.065613 (rank : 755)	θ value	θ > 10 (rank : 1235)
Query Neighborhood Hits	583	Target Neighborhood Hits	877	Shared Neighborhood Hits	88
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ANKK1_HUMAN
NC score	0.065494 (rank : 756)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	583	Target Neighborhood Hits	1075	Shared Neighborhood Hits	93
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

MAK_MOUSE
NC score	0.065438 (rank : 757)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	91
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

E2AK2_MOUSE
NC score	0.065409 (rank : 758)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	583	Target Neighborhood Hits	864	Shared Neighborhood Hits	89
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ULK3_HUMAN
NC score	0.065372 (rank : 759)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ACVR1_HUMAN
NC score	0.065330 (rank : 760)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	583	Target Neighborhood Hits	760	Shared Neighborhood Hits	84
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

CDK4_MOUSE
NC score	0.065201 (rank : 761)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	88
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CHAD_HUMAN
NC score	0.065067 (rank : 762)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	37
SwissProt Accessions	O15335, Q96RJ5	Gene names	CHAD
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

MAK_HUMAN
NC score	0.064951 (rank : 763)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	87
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

BMPR2_HUMAN
NC score	0.064931 (rank : 764)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	583	Target Neighborhood Hits	736	Shared Neighborhood Hits	83
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

ULK1_MOUSE
NC score	0.064874 (rank : 765)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	583	Target Neighborhood Hits	1214	Shared Neighborhood Hits	128
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

FLRT2_HUMAN
NC score	0.064711 (rank : 766)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	48
SwissProt Accessions	O43155	Gene names	FLRT2, KIAA0405
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT2 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 2).

CDK6_MOUSE
NC score	0.064649 (rank : 767)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	88
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

ULK2_HUMAN
NC score	0.064606 (rank : 768)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	583	Target Neighborhood Hits	979	Shared Neighborhood Hits	105
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

NYX_HUMAN
NC score	0.064594 (rank : 769)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZU5, Q5H983, Q9H4J0	Gene names	NYX, CLRP
Domain Architecture
Description	Nyctalopin precursor.

CD226_MOUSE
NC score	0.064519 (rank : 770)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4F0	Gene names	Cd226, Pta1
Domain Architecture
Description	CD226 antigen precursor (Platelet and T-cell activation antigen 1).

STK36_HUMAN
NC score	0.064452 (rank : 771)	θ value	θ > 10 (rank : 1234)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CDK6_HUMAN
NC score	0.064343 (rank : 772)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	88
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

ICK_HUMAN
NC score	0.064316 (rank : 773)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

E2AK3_MOUSE
NC score	0.064233 (rank : 774)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

NEK3_HUMAN
NC score	0.064172 (rank : 775)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	88
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

KS6A3_HUMAN
NC score	0.064129 (rank : 776)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	583	Target Neighborhood Hits	859	Shared Neighborhood Hits	88
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

OXSR1_HUMAN
NC score	0.064110 (rank : 777)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	90
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

KS6A3_MOUSE
NC score	0.064074 (rank : 778)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

CDK4_HUMAN
NC score	0.064034 (rank : 779)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	88
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

ICK_MOUSE
NC score	0.064000 (rank : 780)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

STK39_MOUSE
NC score	0.063910 (rank : 781)	θ value	θ > 10 (rank : 1237)
Query Neighborhood Hits	583	Target Neighborhood Hits	915	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

NEK3_MOUSE
NC score	0.063756 (rank : 782)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

ULK1_HUMAN
NC score	0.063751 (rank : 783)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	583	Target Neighborhood Hits	1121	Shared Neighborhood Hits	106
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK2_MOUSE
NC score	0.063747 (rank : 784)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	583	Target Neighborhood Hits	943	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

OXSR1_MOUSE
NC score	0.063667 (rank : 785)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NUAK2_HUMAN
NC score	0.063640 (rank : 786)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PLK4_MOUSE
NC score	0.063616 (rank : 787)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	583	Target Neighborhood Hits	879	Shared Neighborhood Hits	88
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

CD33_MOUSE
NC score	0.063613 (rank : 788)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	583	Target Neighborhood Hits	45	Shared Neighborhood Hits	31
SwissProt Accessions	Q63994, Q63997	Gene names	Cd33
Domain Architecture
Description	Myeloid cell surface antigen CD33 precursor (Siglec-3).

STK39_HUMAN
NC score	0.063458 (rank : 789)	θ value	θ > 10 (rank : 1236)
Query Neighborhood Hits	583	Target Neighborhood Hits	882	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

CHAD_MOUSE
NC score	0.063418 (rank : 790)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	583	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	O55226	Gene names	Chad
Domain Architecture
Description	Chondroadherin precursor (Cartilage leucine-rich protein).

ST17B_HUMAN
NC score	0.063349 (rank : 791)	θ value	θ > 10 (rank : 1220)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	84
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KS6A2_HUMAN
NC score	0.063224 (rank : 792)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	88
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PLK4_HUMAN
NC score	0.063200 (rank : 793)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	91
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

BMPR2_MOUSE
NC score	0.063171 (rank : 794)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	583	Target Neighborhood Hits	738	Shared Neighborhood Hits	84
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

KS6A1_HUMAN
NC score	0.063110 (rank : 795)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PAK6_HUMAN
NC score	0.063014 (rank : 796)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	583	Target Neighborhood Hits	915	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

NEK1_MOUSE
NC score	0.062989 (rank : 797)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	583	Target Neighborhood Hits	1311	Shared Neighborhood Hits	96
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

LRC15_MOUSE
NC score	0.062926 (rank : 798)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	38
SwissProt Accessions	Q80X72	Gene names	Lrrc15
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 15 precursor.

AURKC_HUMAN
NC score	0.062806 (rank : 799)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ST17A_HUMAN
NC score	0.062788 (rank : 800)	θ value	θ > 10 (rank : 1219)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

PKN1_MOUSE
NC score	0.062787 (rank : 801)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	88
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

NEK1_HUMAN
NC score	0.062781 (rank : 802)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	583	Target Neighborhood Hits	1129	Shared Neighborhood Hits	90
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

IL18R_HUMAN
NC score	0.062779 (rank : 803)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	583	Target Neighborhood Hits	81	Shared Neighborhood Hits	40
SwissProt Accessions	Q13478	Gene names	IL18R1, IL1RRP
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp) (CDw218a antigen).

KS6A2_MOUSE
NC score	0.062690 (rank : 804)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

TIMD1_HUMAN
NC score	0.062556 (rank : 805)	θ value	5.27518 (rank : 538)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

PKN1_HUMAN
NC score	0.062548 (rank : 806)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	89
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

NEK9_HUMAN
NC score	0.062447 (rank : 807)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	583	Target Neighborhood Hits	900	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

E2AK3_HUMAN
NC score	0.062372 (rank : 808)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	583	Target Neighborhood Hits	859	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

ALS_HUMAN
NC score	0.062243 (rank : 809)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	583	Target Neighborhood Hits	280	Shared Neighborhood Hits	39
SwissProt Accessions	P35858	Gene names	IGFALS, ALS
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

FCERA_MOUSE
NC score	0.062224 (rank : 810)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	583	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

MAMC2_MOUSE
NC score	0.062216 (rank : 811)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CG85, Q8BM24	Gene names	Mamdc2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

ACV1C_MOUSE
NC score	0.062137 (rank : 812)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

STK16_MOUSE
NC score	0.061945 (rank : 813)	θ value	θ > 10 (rank : 1227)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	86
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

AURKC_MOUSE
NC score	0.061943 (rank : 814)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AURKB_HUMAN
NC score	0.061920 (rank : 815)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

M3K15_HUMAN
NC score	0.061868 (rank : 816)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	583	Target Neighborhood Hits	914	Shared Neighborhood Hits	88
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NUAK2_MOUSE
NC score	0.061852 (rank : 817)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

STK16_HUMAN
NC score	0.061798 (rank : 818)	θ value	θ > 10 (rank : 1226)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	86
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

MAMC2_HUMAN
NC score	0.061790 (rank : 819)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q7Z304, Q5VW47, Q8WX43, Q96BM4	Gene names	MAMDC2
Domain Architecture
Description	MAM domain-containing protein 2 precursor.

KS6A6_HUMAN
NC score	0.061784 (rank : 820)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

FCGR2_MOUSE
NC score	0.061673 (rank : 821)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	583	Target Neighborhood Hits	105	Shared Neighborhood Hits	52
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

R4RL2_HUMAN
NC score	0.061648 (rank : 822)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	36
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

R4RL2_MOUSE
NC score	0.061610 (rank : 823)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	37
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

NUAK1_HUMAN
NC score	0.061412 (rank : 824)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

M3K5_MOUSE
NC score	0.061394 (rank : 825)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	89
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

CD2L5_MOUSE
NC score	0.061393 (rank : 826)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	583	Target Neighborhood Hits	1011	Shared Neighborhood Hits	96
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

ACV1B_MOUSE
NC score	0.061372 (rank : 827)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

NEK9_MOUSE
NC score	0.061361 (rank : 828)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	583	Target Neighborhood Hits	890	Shared Neighborhood Hits	89
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

CD2L5_HUMAN
NC score	0.061323 (rank : 829)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	583	Target Neighborhood Hits	987	Shared Neighborhood Hits	95
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

AVR2A_MOUSE
NC score	0.061311 (rank : 830)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	583	Target Neighborhood Hits	767	Shared Neighborhood Hits	83
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.061310 (rank : 831)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	583	Target Neighborhood Hits	767	Shared Neighborhood Hits	83
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

GP124_MOUSE
NC score	0.061288 (rank : 832)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	583	Target Neighborhood Hits	423	Shared Neighborhood Hits	57
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

GP124_HUMAN
NC score	0.061283 (rank : 833)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	583	Target Neighborhood Hits	304	Shared Neighborhood Hits	46
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

SN1L2_HUMAN
NC score	0.061276 (rank : 834)	θ value	θ > 10 (rank : 1209)
Query Neighborhood Hits	583	Target Neighborhood Hits	964	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

AAPK1_HUMAN
NC score	0.061252 (rank : 835)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

M3K5_HUMAN
NC score	0.061175 (rank : 836)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	583	Target Neighborhood Hits	868	Shared Neighborhood Hits	88
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

TSK_HUMAN
NC score	0.061106 (rank : 837)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

NEK2_HUMAN
NC score	0.061077 (rank : 838)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	583	Target Neighborhood Hits	908	Shared Neighborhood Hits	88
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NUAK1_MOUSE
NC score	0.061048 (rank : 839)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	583	Target Neighborhood Hits	881	Shared Neighborhood Hits	89
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

IRAK2_HUMAN
NC score	0.061031 (rank : 840)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	583	Target Neighborhood Hits	714	Shared Neighborhood Hits	76
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

AAPK1_MOUSE
NC score	0.061012 (rank : 841)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	89
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

PLK2_MOUSE
NC score	0.060993 (rank : 842)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PAK7_HUMAN
NC score	0.060989 (rank : 843)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

ACV1B_HUMAN
NC score	0.060972 (rank : 844)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	583	Target Neighborhood Hits	753	Shared Neighborhood Hits	85
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

MK07_MOUSE
NC score	0.060931 (rank : 845)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	583	Target Neighborhood Hits	1054	Shared Neighborhood Hits	108
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

STK6_HUMAN
NC score	0.060928 (rank : 846)	θ value	θ > 10 (rank : 1242)
Query Neighborhood Hits	583	Target Neighborhood Hits	916	Shared Neighborhood Hits	92
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

PLK2_HUMAN
NC score	0.060897 (rank : 847)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

RTN4R_HUMAN
NC score	0.060897 (rank : 848)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BZR6	Gene names	RTN4R, NOGOR
Domain Architecture
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

SN1L2_MOUSE
NC score	0.060891 (rank : 849)	θ value	θ > 10 (rank : 1210)
Query Neighborhood Hits	583	Target Neighborhood Hits	944	Shared Neighborhood Hits	98
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

M3K1_MOUSE
NC score	0.060882 (rank : 850)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	583	Target Neighborhood Hits	952	Shared Neighborhood Hits	93
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

PLK1_HUMAN
NC score	0.060802 (rank : 851)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

ALS_MOUSE
NC score	0.060771 (rank : 852)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	583	Target Neighborhood Hits	275	Shared Neighborhood Hits	37
SwissProt Accessions	P70389, Q9DBI7	Gene names	Igfals, Albs, Als
Domain Architecture
Description	Insulin-like growth factor-binding protein complex acid labile chain precursor (ALS).

LR37A_HUMAN
NC score	0.060710 (rank : 853)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	583	Target Neighborhood Hits	720	Shared Neighborhood Hits	86
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

CDK3_HUMAN
NC score	0.060670 (rank : 854)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	87
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

PAK7_MOUSE
NC score	0.060549 (rank : 855)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

CPN2_HUMAN
NC score	0.060473 (rank : 856)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	P22792, Q86SU4, Q8N5V4	Gene names	CPN2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

E2AK1_MOUSE
NC score	0.060344 (rank : 857)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

PLK3_MOUSE
NC score	0.060310 (rank : 858)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	583	Target Neighborhood Hits	863	Shared Neighborhood Hits	89
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

LRC15_HUMAN
NC score	0.060259 (rank : 859)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF66, Q7RTN7	Gene names	LRRC15, LIB
Domain Architecture
Description	Leucine-rich repeat-containing protein 15 precursor (hLib).

KS6A1_MOUSE
NC score	0.060225 (rank : 860)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

SN1L1_MOUSE
NC score	0.060173 (rank : 861)	θ value	θ > 10 (rank : 1208)
Query Neighborhood Hits	583	Target Neighborhood Hits	895	Shared Neighborhood Hits	94
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

PKN3_MOUSE
NC score	0.060166 (rank : 862)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	583	Target Neighborhood Hits	1009	Shared Neighborhood Hits	100
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

SLK_HUMAN
NC score	0.060150 (rank : 863)	θ value	θ > 10 (rank : 1205)
Query Neighborhood Hits	583	Target Neighborhood Hits	1775	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

GPV_MOUSE
NC score	0.060114 (rank : 864)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	37
SwissProt Accessions	O08742	Gene names	Gp5
Domain Architecture	No domain graphic available
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

PKD1_HUMAN
NC score	0.060104 (rank : 865)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	583	Target Neighborhood Hits	387	Shared Neighborhood Hits	47
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

AURKB_MOUSE
NC score	0.060103 (rank : 866)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

MARK2_HUMAN
NC score	0.060074 (rank : 867)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	583	Target Neighborhood Hits	1056	Shared Neighborhood Hits	111
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

SLK_MOUSE
NC score	0.059998 (rank : 868)	θ value	θ > 10 (rank : 1206)
Query Neighborhood Hits	583	Target Neighborhood Hits	1798	Shared Neighborhood Hits	102
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

NEK8_MOUSE
NC score	0.059907 (rank : 869)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	89
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK8_HUMAN
NC score	0.059882 (rank : 870)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	583	Target Neighborhood Hits	872	Shared Neighborhood Hits	88
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

E2AK1_HUMAN
NC score	0.059845 (rank : 871)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

STK6_MOUSE
NC score	0.059726 (rank : 872)	θ value	θ > 10 (rank : 1243)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	92
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

SLAF5_MOUSE
NC score	0.059684 (rank : 873)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	583	Target Neighborhood Hits	93	Shared Neighborhood Hits	53
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

PKN2_HUMAN
NC score	0.059578 (rank : 874)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	583	Target Neighborhood Hits	892	Shared Neighborhood Hits	88
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SREC2_HUMAN
NC score	0.059542 (rank : 875)	θ value	θ > 10 (rank : 1214)
Query Neighborhood Hits	583	Target Neighborhood Hits	645	Shared Neighborhood Hits	62
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MK07_HUMAN
NC score	0.059540 (rank : 876)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	583	Target Neighborhood Hits	1087	Shared Neighborhood Hits	110
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MARK3_HUMAN
NC score	0.059522 (rank : 877)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	95
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

CDK2_HUMAN
NC score	0.059425 (rank : 878)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

R4RL1_HUMAN
NC score	0.059419 (rank : 879)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UN2, Q8ND46	Gene names	RTN4RL1, NGRH2, NGRL2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

PINK1_MOUSE
NC score	0.059411 (rank : 880)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	583	Target Neighborhood Hits	726	Shared Neighborhood Hits	80
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

AMHR2_HUMAN
NC score	0.059404 (rank : 881)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	583	Target Neighborhood Hits	715	Shared Neighborhood Hits	83
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

CDK2_MOUSE
NC score	0.059362 (rank : 882)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

PKN2_MOUSE
NC score	0.059309 (rank : 883)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

CPN2_MOUSE
NC score	0.059279 (rank : 884)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	583	Target Neighborhood Hits	291	Shared Neighborhood Hits	37
SwissProt Accessions	Q9DBB9, Q8R113	Gene names	Cpn2
Domain Architecture	No domain graphic available
Description	Carboxypeptidase N subunit 2 precursor (Carboxypeptidase N polypeptide 2) (Carboxypeptidase N 83 kDa chain) (Carboxypeptidase N regulatory subunit) (Carboxypeptidase N large subunit).

PLK3_HUMAN
NC score	0.059255 (rank : 885)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	583	Target Neighborhood Hits	865	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

MINK1_HUMAN
NC score	0.059238 (rank : 886)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	583	Target Neighborhood Hits	1477	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PKN3_HUMAN
NC score	0.059222 (rank : 887)	θ value	6.88961 (rank : 552)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	94
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

MARK1_HUMAN
NC score	0.059216 (rank : 888)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	583	Target Neighborhood Hits	887	Shared Neighborhood Hits	91
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

SN1L1_HUMAN
NC score	0.059180 (rank : 889)	θ value	θ > 10 (rank : 1207)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	93
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

AAPK2_HUMAN
NC score	0.059143 (rank : 890)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

CDK7_MOUSE
NC score	0.059089 (rank : 891)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDKL2_HUMAN
NC score	0.059041 (rank : 892)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

SLAF5_HUMAN
NC score	0.058921 (rank : 893)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIB8, O15430, O95266, O95660, Q5H9R1, Q6FHA8, Q8WLP1, Q8WWI8, Q9UF04, Q9UIB6, Q9UIB7, Q9UIT7	Gene names	CD84, SLAMF5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen) (Cell surface antigen MAX.3) (Hly9-beta).

KKCC2_HUMAN
NC score	0.058914 (rank : 894)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	90
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
NC score	0.058884 (rank : 895)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	583	Target Neighborhood Hits	855	Shared Neighborhood Hits	89
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

TIMD1_MOUSE
NC score	0.058869 (rank : 896)	θ value	1.38821 (rank : 459)
Query Neighborhood Hits	583	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	Q5QNS5, Q7TPU2, Q8VIM1, Q8VIM2	Gene names	Havcr1, Tim1, Timd1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 homolog precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1).

PAK4_MOUSE
NC score	0.058816 (rank : 897)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	583	Target Neighborhood Hits	1098	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

M3K6_HUMAN
NC score	0.058805 (rank : 898)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	583	Target Neighborhood Hits	889	Shared Neighborhood Hits	95
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

PAK4_HUMAN
NC score	0.058800 (rank : 899)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	100
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CDC2_HUMAN
NC score	0.058777 (rank : 900)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	87
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KPSH2_HUMAN
NC score	0.058743 (rank : 901)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

STK11_HUMAN
NC score	0.058732 (rank : 902)	θ value	θ > 10 (rank : 1225)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	87
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

MARK1_MOUSE
NC score	0.058708 (rank : 903)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

GP1BA_HUMAN
NC score	0.058706 (rank : 904)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	583	Target Neighborhood Hits	407	Shared Neighborhood Hits	53
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

CDK7_HUMAN
NC score	0.058666 (rank : 905)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

MINK1_MOUSE
NC score	0.058628 (rank : 906)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	583	Target Neighborhood Hits	1451	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

NRK_HUMAN
NC score	0.058569 (rank : 907)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	583	Target Neighborhood Hits	931	Shared Neighborhood Hits	90
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

DAPK1_HUMAN
NC score	0.058545 (rank : 908)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	583	Target Neighborhood Hits	1130	Shared Neighborhood Hits	101
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

GPV_HUMAN
NC score	0.058487 (rank : 909)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	583	Target Neighborhood Hits	284	Shared Neighborhood Hits	37
SwissProt Accessions	P40197	Gene names	GP5
Domain Architecture
Description	Platelet glycoprotein V precursor (GPV) (CD42D antigen).

CDC2_MOUSE
NC score	0.058452 (rank : 910)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PLK1_MOUSE
NC score	0.058448 (rank : 911)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KPCD_HUMAN
NC score	0.058407 (rank : 912)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	583	Target Neighborhood Hits	900	Shared Neighborhood Hits	89
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

NIM1_HUMAN
NC score	0.058390 (rank : 913)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MARK3_MOUSE
NC score	0.058346 (rank : 914)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	583	Target Neighborhood Hits	919	Shared Neighborhood Hits	91
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KCC1A_HUMAN
NC score	0.058280 (rank : 915)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

UHMK1_MOUSE
NC score	0.058220 (rank : 916)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	583	Target Neighborhood Hits	809	Shared Neighborhood Hits	80
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MARK2_MOUSE
NC score	0.058215 (rank : 917)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	583	Target Neighborhood Hits	1018	Shared Neighborhood Hits	103
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

KCC1A_MOUSE
NC score	0.058189 (rank : 918)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	583	Target Neighborhood Hits	845	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

TRI42_MOUSE
NC score	0.058166 (rank : 919)	θ value	0.0961366 (rank : 371)
Query Neighborhood Hits	583	Target Neighborhood Hits	316	Shared Neighborhood Hits	37
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TAOK2_HUMAN
NC score	0.058112 (rank : 920)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	583	Target Neighborhood Hits	1172	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

LRTM1_MOUSE
NC score	0.058062 (rank : 921)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	583	Target Neighborhood Hits	264	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K377, Q3UVX1	Gene names	Lrrtm1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

DAPK1_MOUSE
NC score	0.058051 (rank : 922)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	583	Target Neighborhood Hits	1138	Shared Neighborhood Hits	101
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

PAK1_HUMAN
NC score	0.058013 (rank : 923)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	583	Target Neighborhood Hits	873	Shared Neighborhood Hits	92
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

NLK_HUMAN
NC score	0.057979 (rank : 924)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.057971 (rank : 925)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	89
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

CDKL4_MOUSE
NC score	0.057967 (rank : 926)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	86
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

M4K1_HUMAN
NC score	0.057944 (rank : 927)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	92
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

PAK2_MOUSE
NC score	0.057926 (rank : 928)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	88
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

NEK2_MOUSE
NC score	0.057907 (rank : 929)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	583	Target Neighborhood Hits	876	Shared Neighborhood Hits	89
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PAK2_HUMAN
NC score	0.057879 (rank : 930)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	89
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

IKKE_HUMAN
NC score	0.057864 (rank : 931)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	85
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M4K4_MOUSE
NC score	0.057838 (rank : 932)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	583	Target Neighborhood Hits	1560	Shared Neighborhood Hits	93
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

IKKE_MOUSE
NC score	0.057814 (rank : 933)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	583	Target Neighborhood Hits	848	Shared Neighborhood Hits	84
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

PAK1_MOUSE
NC score	0.057781 (rank : 934)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	93
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

RTN4R_MOUSE
NC score	0.057733 (rank : 935)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	39
SwissProt Accessions	Q99PI8, Q80WQ1	Gene names	Rtn4r, Nogor
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor precursor (Nogo receptor) (NgR) (Nogo-66 receptor).

LR37B_HUMAN
NC score	0.057663 (rank : 936)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	583	Target Neighborhood Hits	392	Shared Neighborhood Hits	55
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

KPCD_MOUSE
NC score	0.057661 (rank : 937)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	89
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

UHMK1_HUMAN
NC score	0.057659 (rank : 938)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	583	Target Neighborhood Hits	808	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

M4K1_MOUSE
NC score	0.057606 (rank : 939)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

CDK5_MOUSE
NC score	0.057489 (rank : 940)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	85
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

TPBG_HUMAN
NC score	0.057486 (rank : 941)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	37
SwissProt Accessions	Q13641	Gene names	TPBG, 5T4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein) (5T4 oncofetal antigen) (M6P1).

LRTM4_MOUSE
NC score	0.057463 (rank : 942)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	583	Target Neighborhood Hits	284	Shared Neighborhood Hits	39
SwissProt Accessions	Q80XG9, Q8C030, Q8JZS8	Gene names	Lrrtm4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

CDK5_HUMAN
NC score	0.057392 (rank : 943)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	85
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

M3K3_HUMAN
NC score	0.057373 (rank : 944)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	583	Target Neighborhood Hits	885	Shared Neighborhood Hits	90
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MP2K4_MOUSE
NC score	0.057328 (rank : 945)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K4_HUMAN
NC score	0.057241 (rank : 946)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

KPCT_HUMAN
NC score	0.057220 (rank : 947)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	583	Target Neighborhood Hits	897	Shared Neighborhood Hits	90
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MP2K6_HUMAN
NC score	0.057212 (rank : 948)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K7_HUMAN
NC score	0.057207 (rank : 949)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	87
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

M3K3_MOUSE
NC score	0.057146 (rank : 950)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	583	Target Neighborhood Hits	876	Shared Neighborhood Hits	88
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

CDKL2_MOUSE
NC score	0.057077 (rank : 951)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	583	Target Neighborhood Hits	854	Shared Neighborhood Hits	87
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

MARK4_HUMAN
NC score	0.057058 (rank : 952)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	583	Target Neighborhood Hits	886	Shared Neighborhood Hits	91
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

LRTM4_HUMAN
NC score	0.057050 (rank : 953)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	40
SwissProt Accessions	Q86VH4	Gene names	LRRTM4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 4 precursor.

TSSK6_MOUSE
NC score	0.057049 (rank : 954)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	88
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PDPK1_MOUSE
NC score	0.057039 (rank : 955)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

TNIK_HUMAN
NC score	0.057020 (rank : 956)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	583	Target Neighborhood Hits	1570	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MARK4_MOUSE
NC score	0.056994 (rank : 957)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	583	Target Neighborhood Hits	898	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

STK10_HUMAN
NC score	0.056930 (rank : 958)	θ value	θ > 10 (rank : 1223)
Query Neighborhood Hits	583	Target Neighborhood Hits	1921	Shared Neighborhood Hits	106
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

K0999_MOUSE
NC score	0.056925 (rank : 959)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	583	Target Neighborhood Hits	931	Shared Neighborhood Hits	95
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_HUMAN
NC score	0.056836 (rank : 960)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

PDPK1_HUMAN
NC score	0.056804 (rank : 961)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	88
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

LRTM1_HUMAN
NC score	0.056795 (rank : 962)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UE6, Q96DN1	Gene names	LRRTM1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 1 precursor.

TSSK6_HUMAN
NC score	0.056760 (rank : 963)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	583	Target Neighborhood Hits	824	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

LRTM2_MOUSE
NC score	0.056721 (rank : 964)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGA3, Q80U08	Gene names	Lrrtm2, Kiaa0416
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor.

LRTM2_HUMAN
NC score	0.056716 (rank : 965)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	38
SwissProt Accessions	O43300, Q7L770	Gene names	LRRTM2, KIAA0416, LRRN2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 2 precursor (Leucine-rich repeat neuronal 2 protein).

MP2K3_HUMAN
NC score	0.056688 (rank : 966)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	583	Target Neighborhood Hits	825	Shared Neighborhood Hits	88
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PCTK1_MOUSE
NC score	0.056656 (rank : 967)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_MOUSE
NC score	0.056611 (rank : 968)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MELK_MOUSE
NC score	0.056593 (rank : 969)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	583	Target Neighborhood Hits	860	Shared Neighborhood Hits	88
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

KPCT_MOUSE
NC score	0.056572 (rank : 970)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	583	Target Neighborhood Hits	895	Shared Neighborhood Hits	90
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MP2K2_HUMAN
NC score	0.056558 (rank : 971)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PCTK2_HUMAN
NC score	0.056555 (rank : 972)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	86
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

LGI4_HUMAN
NC score	0.056542 (rank : 973)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N135	Gene names	LGI4, LGIL3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

MP2K6_MOUSE
NC score	0.056490 (rank : 974)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	88
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

GPIX_HUMAN
NC score	0.056475 (rank : 975)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	583	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	P14770, Q14445, Q92525	Gene names	GP9
Domain Architecture
Description	Platelet glycoprotein IX precursor (GPIX) (CD42a antigen).

PAK3_MOUSE
NC score	0.056444 (rank : 976)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	88
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.056403 (rank : 977)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	583	Target Neighborhood Hits	887	Shared Neighborhood Hits	89
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

MK04_HUMAN
NC score	0.056331 (rank : 978)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	84
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MP2K1_HUMAN
NC score	0.056292 (rank : 979)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

PCTK1_HUMAN
NC score	0.056271 (rank : 980)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

MP2K1_MOUSE
NC score	0.056229 (rank : 981)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

CRLF2_MOUSE
NC score	0.056220 (rank : 982)	θ value	5.27518 (rank : 519)
Query Neighborhood Hits	583	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

GRK4_MOUSE
NC score	0.056175 (rank : 983)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	583	Target Neighborhood Hits	808	Shared Neighborhood Hits	87
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MK01_MOUSE
NC score	0.056174 (rank : 984)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	87
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

R4RL1_MOUSE
NC score	0.056119 (rank : 985)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	583	Target Neighborhood Hits	235	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K0S5	Gene names	Rtn4rl1, Ngrl2
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 1 precursor (Nogo-66 receptor homolog 2) (Nogo-66 receptor-related protein 3) (NgR3) (Nogo receptor-like 2).

MK01_HUMAN
NC score	0.056106 (rank : 986)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	87
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

NIM1_MOUSE
NC score	0.056101 (rank : 987)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TAOK2_MOUSE
NC score	0.056060 (rank : 988)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	583	Target Neighborhood Hits	1373	Shared Neighborhood Hits	91
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

M3K8_HUMAN
NC score	0.056047 (rank : 989)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	81
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

CDKL3_HUMAN
NC score	0.056034 (rank : 990)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	583	Target Neighborhood Hits	853	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDK3_MOUSE
NC score	0.056020 (rank : 991)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	87
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CD180_MOUSE
NC score	0.055985 (rank : 992)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	Q62192	Gene names	Cd180, Ly78, Rp105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 78) (Radioprotective 105 kDa protein).

AGRIN_HUMAN
NC score	0.055976 (rank : 993)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	583	Target Neighborhood Hits	582	Shared Neighborhood Hits	53
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

MK03_HUMAN
NC score	0.055819 (rank : 994)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	583	Target Neighborhood Hits	837	Shared Neighborhood Hits	87
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MELK_HUMAN
NC score	0.055773 (rank : 995)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	87
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

TSSK1_MOUSE
NC score	0.055759 (rank : 996)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	86
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KCC1B_MOUSE
NC score	0.055701 (rank : 997)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

MP2K3_MOUSE
NC score	0.055686 (rank : 998)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	88
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PINK1_HUMAN
NC score	0.055670 (rank : 999)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	583	Target Neighborhood Hits	741	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

KPCA_MOUSE
NC score	0.055618 (rank : 1000)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	583	Target Neighborhood Hits	1067	Shared Neighborhood Hits	92
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

NRK_MOUSE
NC score	0.055608 (rank : 1001)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	583	Target Neighborhood Hits	899	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

MK03_MOUSE
NC score	0.055606 (rank : 1002)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	89
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

PFTK1_HUMAN
NC score	0.055580 (rank : 1003)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	88
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

HUNK_HUMAN
NC score	0.055545 (rank : 1004)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	583	Target Neighborhood Hits	884	Shared Neighborhood Hits	90
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

CDKL3_MOUSE
NC score	0.055509 (rank : 1005)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MP2K2_MOUSE
NC score	0.055496 (rank : 1006)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

ASPN_MOUSE
NC score	0.055479 (rank : 1007)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	583	Target Neighborhood Hits	277	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MQ4, Q9D6A2	Gene names	Aspn
Domain Architecture
Description	Asporin precursor.

TSSK4_MOUSE
NC score	0.055471 (rank : 1008)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	583	Target Neighborhood Hits	840	Shared Neighborhood Hits	88
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

PFTK1_MOUSE
NC score	0.055468 (rank : 1009)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KCC1B_HUMAN
NC score	0.055462 (rank : 1010)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	88
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

PRKY_HUMAN
NC score	0.055443 (rank : 1011)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	88
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

AL2S7_HUMAN
NC score	0.055414 (rank : 1012)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	87
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

KKCC1_HUMAN
NC score	0.055383 (rank : 1013)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PCTK3_MOUSE
NC score	0.055358 (rank : 1014)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	583	Target Neighborhood Hits	834	Shared Neighborhood Hits	86
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CD79B_MOUSE
NC score	0.055354 (rank : 1015)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	583	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CDKL4_HUMAN
NC score	0.055343 (rank : 1016)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	86
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

LRC32_HUMAN
NC score	0.055334 (rank : 1017)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	583	Target Neighborhood Hits	303	Shared Neighborhood Hits	37
SwissProt Accessions	Q14392, Q86V06	Gene names	LRRC32, GARP
Domain Architecture
Description	Leucine-rich repeat-containing protein 32 precursor (GARP protein) (Garpin) (Glycoprotein A repetitions predominant).

MK04_MOUSE
NC score	0.055316 (rank : 1018)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	583	Target Neighborhood Hits	852	Shared Neighborhood Hits	81
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

A2GL_HUMAN
NC score	0.055239 (rank : 1019)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	P02750, Q8N4F5, Q96QZ4	Gene names	LRG1, LRG
Domain Architecture
Description	Leucine-rich alpha-2-glycoprotein precursor (LRG).

KKCC1_MOUSE
NC score	0.055230 (rank : 1020)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	583	Target Neighborhood Hits	866	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

TLR13_MOUSE
NC score	0.055209 (rank : 1021)	θ value	θ > 10 (rank : 1266)
Query Neighborhood Hits	583	Target Neighborhood Hits	335	Shared Neighborhood Hits	48
SwissProt Accessions	Q6R5N8, Q3TDS2	Gene names	Tlr13
Domain Architecture	No domain graphic available
Description	Toll-like receptor 13 precursor.

LRTM3_HUMAN
NC score	0.055173 (rank : 1022)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	583	Target Neighborhood Hits	276	Shared Neighborhood Hits	38
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

SREC_HUMAN
NC score	0.055162 (rank : 1023)	θ value	θ > 10 (rank : 1216)
Query Neighborhood Hits	583	Target Neighborhood Hits	645	Shared Neighborhood Hits	49
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

HUNK_MOUSE
NC score	0.055157 (rank : 1024)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	583	Target Neighborhood Hits	874	Shared Neighborhood Hits	89
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

LRRC3_MOUSE
NC score	0.055147 (rank : 1025)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	583	Target Neighborhood Hits	236	Shared Neighborhood Hits	36
SwissProt Accessions	P59034	Gene names	Lrrc3
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

M3K4_HUMAN
NC score	0.055106 (rank : 1026)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	583	Target Neighborhood Hits	911	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

TLR5_HUMAN
NC score	0.055060 (rank : 1027)	θ value	θ > 10 (rank : 1271)
Query Neighborhood Hits	583	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O60602, O15456	Gene names	TLR5, TIL3
Domain Architecture
Description	Toll-like receptor 5 precursor (Toll/interleukin-1 receptor-like protein 3).

KPCB_MOUSE
NC score	0.055045 (rank : 1028)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	583	Target Neighborhood Hits	1117	Shared Neighborhood Hits	92
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPSH1_MOUSE
NC score	0.055035 (rank : 1029)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DCAK1_HUMAN
NC score	0.054974 (rank : 1030)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	583	Target Neighborhood Hits	877	Shared Neighborhood Hits	90
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CDK9_HUMAN
NC score	0.054923 (rank : 1031)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

KPSH1_HUMAN
NC score	0.054899 (rank : 1032)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	583	Target Neighborhood Hits	842	Shared Neighborhood Hits	89
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

LRC17_MOUSE
NC score	0.054894 (rank : 1033)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	583	Target Neighborhood Hits	268	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CXD9	Gene names	Lrrc17
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor.

ASPN_HUMAN
NC score	0.054871 (rank : 1034)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	583	Target Neighborhood Hits	274	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXN1, Q96K79, Q96LD0, Q9NXP3	Gene names	ASPN, PLAP1
Domain Architecture
Description	Asporin precursor (Periodontal ligament-associated protein 1) (PLAP- 1).

DCAK1_MOUSE
NC score	0.054806 (rank : 1035)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MEGF9_MOUSE
NC score	0.054792 (rank : 1036)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	583	Target Neighborhood Hits	896	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

KPCB_HUMAN
NC score	0.054777 (rank : 1037)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	583	Target Neighborhood Hits	1121	Shared Neighborhood Hits	92
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

LRC55_MOUSE
NC score	0.054765 (rank : 1038)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	583	Target Neighborhood Hits	254	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UY51	Gene names	Lrrc55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

KCC1G_HUMAN
NC score	0.054757 (rank : 1039)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	89
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

PCTK3_HUMAN
NC score	0.054716 (rank : 1040)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	583	Target Neighborhood Hits	827	Shared Neighborhood Hits	85
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KCC1G_MOUSE
NC score	0.054696 (rank : 1041)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	583	Target Neighborhood Hits	851	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

CDK9_MOUSE
NC score	0.054694 (rank : 1042)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	88
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

GRK4_HUMAN
NC score	0.054647 (rank : 1043)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	583	Target Neighborhood Hits	822	Shared Neighborhood Hits	89
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MK15_HUMAN
NC score	0.054641 (rank : 1044)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	583	Target Neighborhood Hits	1038	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

M4K3_HUMAN
NC score	0.054577 (rank : 1045)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	89
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

LRTM3_MOUSE
NC score	0.054567 (rank : 1046)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	583	Target Neighborhood Hits	290	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

KCC1D_MOUSE
NC score	0.054533 (rank : 1047)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	89
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

LRC19_MOUSE
NC score	0.054488 (rank : 1048)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	583	Target Neighborhood Hits	238	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BZT5, Q6P8J1	Gene names	Lrrc19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

LRC55_HUMAN
NC score	0.054367 (rank : 1049)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	583	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZSA7	Gene names	LRRC55
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 55.

KCC1D_HUMAN
NC score	0.054355 (rank : 1050)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

LRC52_MOUSE
NC score	0.054241 (rank : 1051)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	583	Target Neighborhood Hits	240	Shared Neighborhood Hits	37
SwissProt Accessions	Q5M8M9	Gene names	Lrrc52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

KPCA_HUMAN
NC score	0.054201 (rank : 1052)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	583	Target Neighborhood Hits	1070	Shared Neighborhood Hits	92
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MEGF9_HUMAN
NC score	0.054190 (rank : 1053)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	583	Target Neighborhood Hits	557	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

CHK1_HUMAN
NC score	0.054186 (rank : 1054)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	88
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

TLR3_MOUSE
NC score	0.054170 (rank : 1055)	θ value	θ > 10 (rank : 1268)
Query Neighborhood Hits	583	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	Q99MB1, Q91ZM4	Gene names	Tlr3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

LGI3_HUMAN
NC score	0.054168 (rank : 1056)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N145, Q86TL4, Q8N296	Gene names	LGI3, LGIL4
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (LGI1-like protein 4).

TPBG_MOUSE
NC score	0.054162 (rank : 1057)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0L0, Q6PE98, Q8BQA4	Gene names	Tpbg, 5t4
Domain Architecture	No domain graphic available
Description	Trophoblast glycoprotein precursor (5T4 oncofetal trophoblast glycoprotein) (5T4 oncotrophoblast glycoprotein).

MOK_MOUSE
NC score	0.054092 (rank : 1058)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	583	Target Neighborhood Hits	796	Shared Neighborhood Hits	74
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

CHK1_MOUSE
NC score	0.054079 (rank : 1059)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	583	Target Neighborhood Hits	839	Shared Neighborhood Hits	87
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M3K4_MOUSE
NC score	0.054057 (rank : 1060)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	583	Target Neighborhood Hits	924	Shared Neighborhood Hits	89
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

TSSK2_HUMAN
NC score	0.054057 (rank : 1061)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	583	Target Neighborhood Hits	826	Shared Neighborhood Hits	86
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

BRSK2_HUMAN
NC score	0.054034 (rank : 1062)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	583	Target Neighborhood Hits	897	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

LGI1_MOUSE
NC score	0.054032 (rank : 1063)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JIA1	Gene names	Lgi1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor.

WEE1_MOUSE
NC score	0.053997 (rank : 1064)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	583	Target Neighborhood Hits	794	Shared Neighborhood Hits	79
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

CDKL5_HUMAN
NC score	0.053980 (rank : 1065)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	583	Target Neighborhood Hits	967	Shared Neighborhood Hits	97
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

SEM4D_HUMAN
NC score	0.053955 (rank : 1066)	θ value	0.00665767 (rank : 312)
Query Neighborhood Hits	583	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

LGI2_HUMAN
NC score	0.053950 (rank : 1067)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N0V4, Q8NDW6, Q96PX2, Q9NVK4	Gene names	LGI2, KIAA1916, LGIL2
Domain Architecture
Description	Leucine-rich repeat LGI family member 2 precursor (Leucine-rich glioma-inactivated protein 2) (LGI1-like protein 2).

M3K8_MOUSE
NC score	0.053919 (rank : 1068)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	81
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

BRSK1_HUMAN
NC score	0.053893 (rank : 1069)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	583	Target Neighborhood Hits	942	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PDK1L_MOUSE
NC score	0.053858 (rank : 1070)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	87
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

NAGPA_MOUSE
NC score	0.053844 (rank : 1071)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	583	Target Neighborhood Hits	308	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BJ48, Q3UUT5, Q8CHQ8, Q9QZE6	Gene names	Nagpa
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

M4K4_HUMAN
NC score	0.053841 (rank : 1072)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	583	Target Neighborhood Hits	1589	Shared Neighborhood Hits	93
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

LAMA5_HUMAN
NC score	0.053823 (rank : 1073)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	583	Target Neighborhood Hits	976	Shared Neighborhood Hits	82
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

MK12_HUMAN
NC score	0.053806 (rank : 1074)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	87
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

LGI1_HUMAN
NC score	0.053729 (rank : 1075)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	583	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	O95970, Q5W001, Q5W002, Q8NI23, Q96LF5	Gene names	LGI1
Domain Architecture
Description	Leucine-rich glioma-inactivated protein 1 precursor (Epitempin-1).

MOK_HUMAN
NC score	0.053687 (rank : 1076)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	583	Target Neighborhood Hits	807	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

TSK_MOUSE
NC score	0.053677 (rank : 1077)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

MK11_HUMAN
NC score	0.053668 (rank : 1078)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	86
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

LRC52_HUMAN
NC score	0.053663 (rank : 1079)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N7C0, Q5T9K5	Gene names	LRRC52
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 52 precursor.

PRKX_MOUSE
NC score	0.053629 (rank : 1080)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PDK1L_HUMAN
NC score	0.053583 (rank : 1081)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	87
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

MK13_HUMAN
NC score	0.053581 (rank : 1082)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	87
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
NC score	0.053569 (rank : 1083)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

LGI4_MOUSE
NC score	0.053527 (rank : 1084)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K1S1, Q8K4Y8	Gene names	Lgi4, Lgil3
Domain Architecture
Description	Leucine-rich repeat LGI family member 4 precursor (Leucine-rich glioma-inactivated protein 4) (LGI1-like protein 3).

CCRK_HUMAN
NC score	0.053516 (rank : 1085)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

TBK1_HUMAN
NC score	0.053504 (rank : 1086)	θ value	θ > 10 (rank : 1252)
Query Neighborhood Hits	583	Target Neighborhood Hits	861	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

M3K2_HUMAN
NC score	0.053473 (rank : 1087)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

LAMA5_MOUSE
NC score	0.053444 (rank : 1088)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	583	Target Neighborhood Hits	828	Shared Neighborhood Hits	68
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

CI096_HUMAN
NC score	0.053381 (rank : 1089)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	583	Target Neighborhood Hits	821	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

GRK6_HUMAN
NC score	0.053349 (rank : 1090)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	87
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MK14_HUMAN
NC score	0.053326 (rank : 1091)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

STK35_HUMAN
NC score	0.053240 (rank : 1092)	θ value	θ > 10 (rank : 1233)
Query Neighborhood Hits	583	Target Neighborhood Hits	825	Shared Neighborhood Hits	85
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

GRK6_MOUSE
NC score	0.053201 (rank : 1093)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	583	Target Neighborhood Hits	820	Shared Neighborhood Hits	87
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MK12_MOUSE
NC score	0.053115 (rank : 1094)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	88
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PGS1_MOUSE
NC score	0.053062 (rank : 1095)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	583	Target Neighborhood Hits	265	Shared Neighborhood Hits	38
SwissProt Accessions	P28653, Q61355	Gene names	Bgn
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

TBK1_MOUSE
NC score	0.053059 (rank : 1096)	θ value	θ > 10 (rank : 1253)
Query Neighborhood Hits	583	Target Neighborhood Hits	893	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

STK10_MOUSE
NC score	0.053044 (rank : 1097)	θ value	θ > 10 (rank : 1224)
Query Neighborhood Hits	583	Target Neighborhood Hits	2132	Shared Neighborhood Hits	100
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

LRC33_HUMAN
NC score	0.053037 (rank : 1098)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	583	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	Q86YC3	Gene names	LRRC33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

LGI3_MOUSE
NC score	0.052975 (rank : 1099)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	583	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K406	Gene names	Lgi3
Domain Architecture
Description	Leucine-rich repeat LGI family member 3 precursor (Leucine-rich glioma-inactivated protein 3) (Leubrin).

PGS1_HUMAN
NC score	0.052974 (rank : 1100)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	583	Target Neighborhood Hits	261	Shared Neighborhood Hits	38
SwissProt Accessions	P21810, P13247	Gene names	BGN
Domain Architecture
Description	Biglycan precursor (Bone/cartilage proteoglycan I) (PG-S1).

GP1BB_MOUSE
NC score	0.052958 (rank : 1101)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	33
SwissProt Accessions	P56400	Gene names	Gp1bb
Domain Architecture
Description	Platelet glycoprotein Ib beta chain precursor (GP-Ib beta) (GPIbB) (GPIb-beta) (CD42c antigen).

KS6B1_MOUSE
NC score	0.052936 (rank : 1102)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	583	Target Neighborhood Hits	849	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.052881 (rank : 1103)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	88
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

M4K2_MOUSE
NC score	0.052845 (rank : 1104)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	583	Target Neighborhood Hits	843	Shared Neighborhood Hits	87
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

SREC2_MOUSE
NC score	0.052639 (rank : 1105)	θ value	θ > 10 (rank : 1215)
Query Neighborhood Hits	583	Target Neighborhood Hits	605	Shared Neighborhood Hits	56
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

CDKL1_HUMAN
NC score	0.052601 (rank : 1106)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	86
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

SCYL2_MOUSE
NC score	0.052498 (rank : 1107)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	583	Target Neighborhood Hits	603	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

LGR5_HUMAN
NC score	0.052493 (rank : 1108)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	583	Target Neighborhood Hits	452	Shared Neighborhood Hits	37
SwissProt Accessions	O75473, Q9UP75	Gene names	LGR5, GPR49, GPR67
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (Orphan G-protein coupled receptor HG38) (G-protein coupled receptor 49) (G-protein coupled receptor 67).

MK14_MOUSE
NC score	0.052486 (rank : 1109)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

PGS2_MOUSE
NC score	0.052427 (rank : 1110)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	36
SwissProt Accessions	P28654	Gene names	Dcn
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

CD180_HUMAN
NC score	0.052427 (rank : 1111)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	34
SwissProt Accessions	Q99467	Gene names	CD180, LY64, RP105
Domain Architecture
Description	CD180 antigen precursor (Lymphocyte antigen 64) (Radioprotective 105 kDa protein).

TAOK3_HUMAN
NC score	0.052348 (rank : 1112)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	583	Target Neighborhood Hits	1494	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TSSK2_MOUSE
NC score	0.052348 (rank : 1113)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	86
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

AL2S2_MOUSE
NC score	0.052282 (rank : 1114)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	583	Target Neighborhood Hits	709	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ERN1_HUMAN
NC score	0.052238 (rank : 1115)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	85
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M4K2_HUMAN
NC score	0.052216 (rank : 1116)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	583	Target Neighborhood Hits	850	Shared Neighborhood Hits	89
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

TLR3_HUMAN
NC score	0.052111 (rank : 1117)	θ value	θ > 10 (rank : 1267)
Query Neighborhood Hits	583	Target Neighborhood Hits	323	Shared Neighborhood Hits	41
SwissProt Accessions	O15455	Gene names	TLR3
Domain Architecture
Description	Toll-like receptor 3 precursor (CD283 antigen).

MAPK3_MOUSE
NC score	0.052075 (rank : 1118)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	583	Target Neighborhood Hits	811	Shared Neighborhood Hits	86
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

NACAM_MOUSE
NC score	0.052038 (rank : 1119)	θ value	2.36792 (rank : 483)
Query Neighborhood Hits	583	Target Neighborhood Hits	1866	Shared Neighborhood Hits	137
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PRKX_HUMAN
NC score	0.052024 (rank : 1120)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	583	Target Neighborhood Hits	847	Shared Neighborhood Hits	88
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

DCAK3_HUMAN
NC score	0.051986 (rank : 1121)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	583	Target Neighborhood Hits	888	Shared Neighborhood Hits	91
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

LRC19_HUMAN
NC score	0.051980 (rank : 1122)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H756	Gene names	LRRC19
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 19 precursor.

CD2L1_MOUSE
NC score	0.051931 (rank : 1123)	θ value	1.38821 (rank : 450)
Query Neighborhood Hits	583	Target Neighborhood Hits	1463	Shared Neighborhood Hits	97
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

PP1R7_HUMAN
NC score	0.051838 (rank : 1124)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	583	Target Neighborhood Hits	265	Shared Neighborhood Hits	31
SwissProt Accessions	Q15435, Q9UQE5, Q9UQE6, Q9Y6K4	Gene names	PPP1R7, SDS22
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22).

CDKL1_MOUSE
NC score	0.051822 (rank : 1125)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	583	Target Neighborhood Hits	829	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

TSSK4_HUMAN
NC score	0.051808 (rank : 1126)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	88
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

GRK5_MOUSE
NC score	0.051796 (rank : 1127)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_HUMAN
NC score	0.051755 (rank : 1128)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	583	Target Neighborhood Hits	819	Shared Neighborhood Hits	87
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

TLR5_MOUSE
NC score	0.051714 (rank : 1129)	θ value	θ > 10 (rank : 1272)
Query Neighborhood Hits	583	Target Neighborhood Hits	287	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLF7	Gene names	Tlr5
Domain Architecture
Description	Toll-like receptor 5 precursor.

PASK_HUMAN
NC score	0.051632 (rank : 1130)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	583	Target Neighborhood Hits	857	Shared Neighborhood Hits	88
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

CDK10_HUMAN
NC score	0.051616 (rank : 1131)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

PASK_MOUSE
NC score	0.051571 (rank : 1132)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	583	Target Neighborhood Hits	867	Shared Neighborhood Hits	88
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KPCD2_HUMAN
NC score	0.051546 (rank : 1133)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	583	Target Neighborhood Hits	910	Shared Neighborhood Hits	89
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

LGR5_MOUSE
NC score	0.051541 (rank : 1134)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	583	Target Neighborhood Hits	484	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1P4	Gene names	Lgr5, Fex, Gpr49
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX).

LGR4_HUMAN
NC score	0.051510 (rank : 1135)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	583	Target Neighborhood Hits	481	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

MAPK2_HUMAN
NC score	0.051491 (rank : 1136)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	583	Target Neighborhood Hits	844	Shared Neighborhood Hits	91
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

TAOK1_HUMAN
NC score	0.051459 (rank : 1137)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	583	Target Neighborhood Hits	1734	Shared Neighborhood Hits	98
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ZAN_HUMAN
NC score	0.051457 (rank : 1138)	θ value	0.62314 (rank : 424)
Query Neighborhood Hits	583	Target Neighborhood Hits	679	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

MK11_MOUSE
NC score	0.051433 (rank : 1139)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	583	Target Neighborhood Hits	835	Shared Neighborhood Hits	89
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

TAOK3_MOUSE
NC score	0.051431 (rank : 1140)	θ value	θ > 10 (rank : 1251)
Query Neighborhood Hits	583	Target Neighborhood Hits	1458	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CCRK_MOUSE
NC score	0.051417 (rank : 1141)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	583	Target Neighborhood Hits	832	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

NAGPA_HUMAN
NC score	0.051397 (rank : 1142)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	583	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UK23, Q96EJ8	Gene names	NAGPA
Domain Architecture	No domain graphic available
Description	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precursor (EC 3.1.4.45) (Phosphodiester alpha-GlcNAcase) (Mannose 6- phosphate-uncovering enzyme).

TAOK1_MOUSE
NC score	0.051372 (rank : 1143)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	583	Target Neighborhood Hits	1720	Shared Neighborhood Hits	98
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TLR4_MOUSE
NC score	0.051358 (rank : 1144)	θ value	θ > 10 (rank : 1270)
Query Neighborhood Hits	583	Target Neighborhood Hits	279	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUK6, Q9D691, Q9QZF5, Q9Z203	Gene names	Tlr4, Lps
Domain Architecture
Description	Toll-like receptor 4 precursor (CD284 antigen).

M3K2_MOUSE
NC score	0.051328 (rank : 1145)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	583	Target Neighborhood Hits	846	Shared Neighborhood Hits	88
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

KGP1A_HUMAN
NC score	0.051309 (rank : 1146)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	583	Target Neighborhood Hits	901	Shared Neighborhood Hits	90
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KCC2G_MOUSE
NC score	0.051279 (rank : 1147)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	583	Target Neighborhood Hits	838	Shared Neighborhood Hits	87
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.051276 (rank : 1148)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	583	Target Neighborhood Hits	841	Shared Neighborhood Hits	87
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

ERN1_MOUSE
NC score	0.051247 (rank : 1149)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	583	Target Neighborhood Hits	823	Shared Neighborhood Hits	84
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK06_MOUSE
NC score	0.051229 (rank : 1150)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	583	Target Neighborhood Hits	818	Shared Neighborhood Hits	80
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

KGP1B_HUMAN
NC score	0.051199 (rank : 1151)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	583	Target Neighborhood Hits	921	Shared Neighborhood Hits	89
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
NC score	0.051196 (rank : 1152)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	583	Target Neighborhood Hits	922	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MK06_HUMAN
NC score	0.051153 (rank : 1153)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	583	Target Neighborhood Hits	815	Shared Neighborhood Hits	80
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

DCAK3_MOUSE
NC score	0.051142 (rank : 1154)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	583	Target Neighborhood Hits	922	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

MAPK2_MOUSE
NC score	0.051081 (rank : 1155)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	583	Target Neighborhood Hits	831	Shared Neighborhood Hits	88
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

LRC17_HUMAN
NC score	0.051063 (rank : 1156)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	583	Target Neighborhood Hits	267	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

KAPCG_HUMAN
NC score	0.051053 (rank : 1157)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	583	Target Neighborhood Hits	845	Shared Neighborhood Hits	88
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

PGS2_HUMAN
NC score	0.051048 (rank : 1158)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	583	Target Neighborhood Hits	271	Shared Neighborhood Hits	35
SwissProt Accessions	P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9	Gene names	DCN
Domain Architecture
Description	Decorin precursor (Bone proteoglycan II) (PG-S2) (PG40).

DCAK2_MOUSE
NC score	0.051024 (rank : 1159)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	89
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

SIGIR_HUMAN
NC score	0.050820 (rank : 1160)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	583	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TTK_HUMAN
NC score	0.050817 (rank : 1161)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	583	Target Neighborhood Hits	816	Shared Neighborhood Hits	80
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

SCYL2_HUMAN
NC score	0.050765 (rank : 1162)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	583	Target Neighborhood Hits	632	Shared Neighborhood Hits	70
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TLR9_HUMAN
NC score	0.050695 (rank : 1163)	θ value	θ > 10 (rank : 1273)
Query Neighborhood Hits	583	Target Neighborhood Hits	295	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR96, Q6UVZ2, Q9HD68, Q9HD69, Q9HD70, Q9NYC2, Q9NYC3	Gene names	TLR9
Domain Architecture
Description	Toll-like receptor 9 precursor (CD289 antigen).

LGR6_HUMAN
NC score	0.050652 (rank : 1164)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBX8, Q5T509, Q5T512, Q6UY15, Q86VU0, Q96K69, Q9BYD7	Gene names	LGR6
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 6 (VTS20631).

TLR4_HUMAN
NC score	0.050641 (rank : 1165)	θ value	θ > 10 (rank : 1269)
Query Neighborhood Hits	583	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	O00206, Q9UK78, Q9UM57	Gene names	TLR4
Domain Architecture
Description	Toll-like receptor 4 precursor (hToll) (CD284 antigen).

LRRC3_HUMAN
NC score	0.050564 (rank : 1166)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	583	Target Neighborhood Hits	232	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BY71	Gene names	LRRC3, C21orf102
Domain Architecture
Description	Leucine-rich repeat-containing protein 3 precursor.

KCC2A_HUMAN
NC score	0.050532 (rank : 1167)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	583	Target Neighborhood Hits	830	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

WNK2_HUMAN
NC score	0.050493 (rank : 1168)	θ value	5.27518 (rank : 540)
Query Neighborhood Hits	583	Target Neighborhood Hits	1407	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

LRC33_MOUSE
NC score	0.050471 (rank : 1169)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	583	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMT4, Q3TIA8, Q8BTT4, Q8BUI7, Q8BY16, Q8R063	Gene names	Lrrc33
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 33 precursor.

DCAK2_HUMAN
NC score	0.050439 (rank : 1170)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	583	Target Neighborhood Hits	862	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

AKT2_HUMAN
NC score	0.050416 (rank : 1171)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	583	Target Neighborhood Hits	878	Shared Neighborhood Hits	88
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

MK10_HUMAN
NC score	0.050372 (rank : 1172)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	583	Target Neighborhood Hits	836	Shared Neighborhood Hits	90
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

FCGR3_MOUSE
NC score	0.050341 (rank : 1173)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	583	Target Neighborhood Hits	98	Shared Neighborhood Hits	44
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

ST32A_MOUSE
NC score	0.050331 (rank : 1174)	θ value	θ > 10 (rank : 1222)
Query Neighborhood Hits	583	Target Neighborhood Hits	833	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

PRRT3_HUMAN
NC score	0.050243 (rank : 1175)	θ value	0.0961366 (rank : 366)
Query Neighborhood Hits	583	Target Neighborhood Hits	998	Shared Neighborhood Hits	78
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

AKT2_MOUSE
NC score	0.050112 (rank : 1176)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	583	Target Neighborhood Hits	875	Shared Neighborhood Hits	88
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KS6B2_HUMAN
NC score	0.050108 (rank : 1177)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	583	Target Neighborhood Hits	858	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

SNRK_HUMAN
NC score	0.050074 (rank : 1178)	θ value	θ > 10 (rank : 1211)
Query Neighborhood Hits	583	Target Neighborhood Hits	855	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

BT2A3_HUMAN
NC score	0.045705 (rank : 1179)	θ value	0.00869519 (rank : 314)
Query Neighborhood Hits	583	Target Neighborhood Hits	195	Shared Neighborhood Hits	71
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

TREM2_HUMAN
NC score	0.045046 (rank : 1180)	θ value	0.365318 (rank : 403)
Query Neighborhood Hits	583	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

ALEX_HUMAN
NC score	0.043662 (rank : 1181)	θ value	0.163984 (rank : 378)
Query Neighborhood Hits	583	Target Neighborhood Hits	361	Shared Neighborhood Hits	37
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

TIMD2_MOUSE
NC score	0.042958 (rank : 1182)	θ value	8.99809 (rank : 581)
Query Neighborhood Hits	583	Target Neighborhood Hits	51	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

PCLO_MOUSE
NC score	0.042124 (rank : 1183)	θ value	7.1131e-05 (rank : 244)
Query Neighborhood Hits	583	Target Neighborhood Hits	2275	Shared Neighborhood Hits	115
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

MDC1_HUMAN
NC score	0.041828 (rank : 1184)	θ value	0.813845 (rank : 428)
Query Neighborhood Hits	583	Target Neighborhood Hits	1446	Shared Neighborhood Hits	95
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

TIMD3_MOUSE
NC score	0.039530 (rank : 1185)	θ value	8.99809 (rank : 582)
Query Neighborhood Hits	583	Target Neighborhood Hits	78	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VIM0	Gene names	Havcr2, Tim3, Timd3
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 2 homolog precursor (HAVcr-2) (T cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T cell membrane protein 3) (TIM-3).

ERMAP_MOUSE
NC score	0.039294 (rank : 1186)	θ value	2.36792 (rank : 480)
Query Neighborhood Hits	583	Target Neighborhood Hits	231	Shared Neighborhood Hits	89
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

MUC2_HUMAN
NC score	0.039154 (rank : 1187)	θ value	0.125558 (rank : 376)
Query Neighborhood Hits	583	Target Neighborhood Hits	906	Shared Neighborhood Hits	81
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ZPBP2_HUMAN
NC score	0.038764 (rank : 1188)	θ value	0.125558 (rank : 377)
Query Neighborhood Hits	583	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X784, Q6X783, Q86XL5	Gene names	ZPBP2, ZPBPL
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor (ZPBP-like protein).

PO121_HUMAN
NC score	0.038712 (rank : 1189)	θ value	0.0563607 (rank : 357)
Query Neighborhood Hits	583	Target Neighborhood Hits	344	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

CD248_HUMAN
NC score	0.038362 (rank : 1190)	θ value	0.00869519 (rank : 315)
Query Neighborhood Hits	583	Target Neighborhood Hits	679	Shared Neighborhood Hits	72
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

SEM4D_MOUSE
NC score	0.037654 (rank : 1191)	θ value	0.163984 (rank : 381)
Query Neighborhood Hits	583	Target Neighborhood Hits	143	Shared Neighborhood Hits	46
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

DCP1A_HUMAN
NC score	0.036668 (rank : 1192)	θ value	0.0252991 (rank : 332)
Query Neighborhood Hits	583	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

SEM3C_MOUSE
NC score	0.036269 (rank : 1193)	θ value	0.813845 (rank : 431)
Query Neighborhood Hits	583	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

LRP10_HUMAN
NC score	0.035500 (rank : 1194)	θ value	5.27518 (rank : 528)
Query Neighborhood Hits	583	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

RPB1_HUMAN
NC score	0.035364 (rank : 1195)	θ value	0.0961366 (rank : 368)
Query Neighborhood Hits	583	Target Neighborhood Hits	362	Shared Neighborhood Hits	41
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
NC score	0.035352 (rank : 1196)	θ value	0.0961366 (rank : 369)
Query Neighborhood Hits	583	Target Neighborhood Hits	363	Shared Neighborhood Hits	41
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

TIMD4_MOUSE
NC score	0.034188 (rank : 1197)	θ value	3.0926 (rank : 498)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	Q6U7R4, Q6U7R3, Q8CIC7	Gene names	Timd4, Tim4
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 4 precursor (TIMD-4) (T-cell membrane protein 4) (TIM-4) (Spleen, mucin- containing, knockout of lymphotoxin protein) (SMUCKLER).

PRG4_HUMAN
NC score	0.032211 (rank : 1198)	θ value	0.365318 (rank : 402)
Query Neighborhood Hits	583	Target Neighborhood Hits	764	Shared Neighborhood Hits	58
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PI5PA_MOUSE
NC score	0.031982 (rank : 1199)	θ value	0.0563607 (rank : 356)
Query Neighborhood Hits	583	Target Neighborhood Hits	331	Shared Neighborhood Hits	36
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

ZPBP1_HUMAN
NC score	0.031698 (rank : 1200)	θ value	1.81305 (rank : 477)
Query Neighborhood Hits	583	Target Neighborhood Hits	17	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BS86, Q15941, Q75KX9, Q75MI3	Gene names	ZPBP, ZPBP1
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 1 precursor (Sp38).

PRG4_MOUSE
NC score	0.031220 (rank : 1201)	θ value	1.81305 (rank : 472)
Query Neighborhood Hits	583	Target Neighborhood Hits	624	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

WASF2_HUMAN
NC score	0.030914 (rank : 1202)	θ value	0.365318 (rank : 404)
Query Neighborhood Hits	583	Target Neighborhood Hits	280	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WBS14_MOUSE
NC score	0.030639 (rank : 1203)	θ value	4.03905 (rank : 514)
Query Neighborhood Hits	583	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

CCNK_MOUSE
NC score	0.030600 (rank : 1204)	θ value	0.0563607 (rank : 352)
Query Neighborhood Hits	583	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

SEM3C_HUMAN
NC score	0.030587 (rank : 1205)	θ value	5.27518 (rank : 535)
Query Neighborhood Hits	583	Target Neighborhood Hits	106	Shared Neighborhood Hits	51
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

TAU_HUMAN
NC score	0.030497 (rank : 1206)	θ value	1.06291 (rank : 447)
Query Neighborhood Hits	583	Target Neighborhood Hits	448	Shared Neighborhood Hits	44
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ENAM_HUMAN
NC score	0.030433 (rank : 1207)	θ value	1.38821 (rank : 451)
Query Neighborhood Hits	583	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

FANK1_HUMAN
NC score	0.030376 (rank : 1208)	θ value	4.03905 (rank : 505)
Query Neighborhood Hits	583	Target Neighborhood Hits	326	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

WASF2_MOUSE
NC score	0.029768 (rank : 1209)	θ value	0.47712 (rank : 415)
Query Neighborhood Hits	583	Target Neighborhood Hits	315	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

NOTC2_HUMAN
NC score	0.029717 (rank : 1210)	θ value	8.99809 (rank : 575)
Query Neighborhood Hits	583	Target Neighborhood Hits	1113	Shared Neighborhood Hits	94
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

BT2A2_HUMAN
NC score	0.029561 (rank : 1211)	θ value	5.27518 (rank : 515)
Query Neighborhood Hits	583	Target Neighborhood Hits	191	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

K0310_HUMAN
NC score	0.029109 (rank : 1212)	θ value	1.38821 (rank : 454)
Query Neighborhood Hits	583	Target Neighborhood Hits	420	Shared Neighborhood Hits	44
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

RGS3_MOUSE
NC score	0.028992 (rank : 1213)	θ value	4.03905 (rank : 512)
Query Neighborhood Hits	583	Target Neighborhood Hits	1621	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

FANK1_MOUSE
NC score	0.028684 (rank : 1214)	θ value	5.27518 (rank : 521)
Query Neighborhood Hits	583	Target Neighborhood Hits	325	Shared Neighborhood Hits	47
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

NCOA6_HUMAN
NC score	0.028666 (rank : 1215)	θ value	1.81305 (rank : 468)
Query Neighborhood Hits	583	Target Neighborhood Hits	1202	Shared Neighborhood Hits	88
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MAGE1_HUMAN
NC score	0.028194 (rank : 1216)	θ value	6.88961 (rank : 547)
Query Neighborhood Hits	583	Target Neighborhood Hits	1389	Shared Neighborhood Hits	111
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

GSCR1_HUMAN
NC score	0.027618 (rank : 1217)	θ value	8.99809 (rank : 571)
Query Neighborhood Hits	583	Target Neighborhood Hits	674	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

PPRB_HUMAN
NC score	0.027399 (rank : 1218)	θ value	1.06291 (rank : 443)
Query Neighborhood Hits	583	Target Neighborhood Hits	311	Shared Neighborhood Hits	23
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

TTBK1_HUMAN
NC score	0.026817 (rank : 1219)	θ value	2.36792 (rank : 487)
Query Neighborhood Hits	583	Target Neighborhood Hits	1058	Shared Neighborhood Hits	70
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

SLAF9_HUMAN
NC score	0.026766 (rank : 1220)	θ value	0.813845 (rank : 433)
Query Neighborhood Hits	583	Target Neighborhood Hits	35	Shared Neighborhood Hits	16
SwissProt Accessions	Q96A28, Q5JRQ9, Q5JRR0, Q6UWG1	Gene names	SLAMF9, CD2F10
Domain Architecture	No domain graphic available
Description	SLAM family member 9 precursor (CD2 family member 10) (CD2F-10) (CD84 homolog 1) (CD84-H1).

PGCA_MOUSE
NC score	0.026566 (rank : 1221)	θ value	5.27518 (rank : 533)
Query Neighborhood Hits	583	Target Neighborhood Hits	643	Shared Neighborhood Hits	90
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

NCOA6_MOUSE
NC score	0.025619 (rank : 1222)	θ value	1.81305 (rank : 469)
Query Neighborhood Hits	583	Target Neighborhood Hits	1076	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RERE_HUMAN
NC score	0.025600 (rank : 1223)	θ value	0.0961366 (rank : 367)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SF3A1_HUMAN
NC score	0.025378 (rank : 1224)	θ value	1.81305 (rank : 475)
Query Neighborhood Hits	583	Target Neighborhood Hits	199	Shared Neighborhood Hits	22
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

CSPG3_HUMAN
NC score	0.024633 (rank : 1225)	θ value	0.62314 (rank : 417)
Query Neighborhood Hits	583	Target Neighborhood Hits	676	Shared Neighborhood Hits	73
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

GGN_MOUSE
NC score	0.023908 (rank : 1226)	θ value	1.81305 (rank : 463)
Query Neighborhood Hits	583	Target Neighborhood Hits	311	Shared Neighborhood Hits	31
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

FA47A_HUMAN
NC score	0.023550 (rank : 1227)	θ value	8.99809 (rank : 570)
Query Neighborhood Hits	583	Target Neighborhood Hits	451	Shared Neighborhood Hits	45
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

WBS14_HUMAN
NC score	0.023514 (rank : 1228)	θ value	3.0926 (rank : 499)
Query Neighborhood Hits	583	Target Neighborhood Hits	273	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

SF3A1_MOUSE
NC score	0.023348 (rank : 1229)	θ value	1.81305 (rank : 476)
Query Neighborhood Hits	583	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K4Z5, Q8C0M7, Q8C128, Q8C175, Q921T3	Gene names	Sf3a1
Domain Architecture	No domain graphic available
Description	Splicing factor 3 subunit 1 (SF3a120).

SYNJ1_MOUSE
NC score	0.023264 (rank : 1230)	θ value	0.47712 (rank : 413)
Query Neighborhood Hits	583	Target Neighborhood Hits	516	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

GGA3_MOUSE
NC score	0.023154 (rank : 1231)	θ value	0.21417 (rank : 385)
Query Neighborhood Hits	583	Target Neighborhood Hits	148	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

SAM68_MOUSE
NC score	0.022842 (rank : 1232)	θ value	1.38821 (rank : 456)
Query Neighborhood Hits	583	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	Q60749, Q3U8T3, Q60735, Q99M33	Gene names	Khdrbs1
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

IGX1_MOUSE
NC score	0.022801 (rank : 1233)	θ value	2.36792 (rank : 481)
Query Neighborhood Hits	583	Target Neighborhood Hits	44	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R0A6	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

EMD_HUMAN
NC score	0.022241 (rank : 1234)	θ value	0.47712 (rank : 405)
Query Neighborhood Hits	583	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P50402	Gene names	EMD, EDMD, STA
Domain Architecture
Description	Emerin.

YETS2_MOUSE
NC score	0.022220 (rank : 1235)	θ value	1.06291 (rank : 448)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	34
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

MTFR1_MOUSE
NC score	0.022212 (rank : 1236)	θ value	1.81305 (rank : 467)
Query Neighborhood Hits	583	Target Neighborhood Hits	38	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MB2, Q9CQZ4	Gene names	Mtfr1, Kiaa0009
Domain Architecture	No domain graphic available
Description	Mitochondrial fission regulator 1.

GGA3_HUMAN
NC score	0.021521 (rank : 1237)	θ value	0.0431538 (rank : 348)
Query Neighborhood Hits	583	Target Neighborhood Hits	127	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NZ52, Q15017, Q6IS16, Q9UJY3	Gene names	GGA3, KIAA0154
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

WASIP_HUMAN
NC score	0.021305 (rank : 1238)	θ value	6.88961 (rank : 559)
Query Neighborhood Hits	583	Target Neighborhood Hits	458	Shared Neighborhood Hits	32
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

RAPH1_HUMAN
NC score	0.021250 (rank : 1239)	θ value	8.99809 (rank : 578)
Query Neighborhood Hits	583	Target Neighborhood Hits	593	Shared Neighborhood Hits	42
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

CSKI1_MOUSE
NC score	0.021139 (rank : 1240)	θ value	1.81305 (rank : 461)
Query Neighborhood Hits	583	Target Neighborhood Hits	1031	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MLL2_HUMAN
NC score	0.021098 (rank : 1241)	θ value	0.0330416 (rank : 342)
Query Neighborhood Hits	583	Target Neighborhood Hits	1788	Shared Neighborhood Hits	83
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

LIRB3_HUMAN
NC score	0.021033 (rank : 1242)	θ value	1.38821 (rank : 455)
Query Neighborhood Hits	583	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	O75022, O15471, Q86U49	Gene names	LILRB3, ILT5, LIR3
Domain Architecture	No domain graphic available
Description	Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor (Leukocyte immunoglobulin-like receptor 3) (LIR-3) (Immunoglobulin- like transcript 5) (ILT-5) (Monocyte inhibitory receptor HL9) (CD85a antigen).

YLPM1_MOUSE
NC score	0.020766 (rank : 1243)	θ value	6.88961 (rank : 561)
Query Neighborhood Hits	583	Target Neighborhood Hits	505	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

CHCH6_MOUSE
NC score	0.020271 (rank : 1244)	θ value	0.813845 (rank : 426)
Query Neighborhood Hits	583	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VN4	Gene names	Chchd6
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 6.

NFRKB_MOUSE
NC score	0.019849 (rank : 1245)	θ value	6.88961 (rank : 549)
Query Neighborhood Hits	583	Target Neighborhood Hits	393	Shared Neighborhood Hits	39
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

RU1C_MOUSE
NC score	0.018434 (rank : 1246)	θ value	8.99809 (rank : 579)
Query Neighborhood Hits	583	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q62241	Gene names	Snrp1c, Snrpc
Domain Architecture
Description	U1 small nuclear ribonucleoprotein C (U1 snRNP protein C) (U1C protein) (U1-C).

ENAH_MOUSE
NC score	0.018416 (rank : 1247)	θ value	0.62314 (rank : 418)
Query Neighborhood Hits	583	Target Neighborhood Hits	919	Shared Neighborhood Hits	41
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

SEM3F_MOUSE
NC score	0.018408 (rank : 1248)	θ value	4.03905 (rank : 513)
Query Neighborhood Hits	583	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	O88632, O88633	Gene names	Sema3f
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV).

PPRB_MOUSE
NC score	0.017377 (rank : 1249)	θ value	2.36792 (rank : 485)
Query Neighborhood Hits	583	Target Neighborhood Hits	354	Shared Neighborhood Hits	27
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

ZPBP2_MOUSE
NC score	0.017374 (rank : 1250)	θ value	6.88961 (rank : 562)
Query Neighborhood Hits	583	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q6X786, Q6X785, Q9DA91	Gene names	Zpbp2
Domain Architecture	No domain graphic available
Description	Zona pellucida-binding protein 2 precursor.

SVIL_MOUSE
NC score	0.017265 (rank : 1251)	θ value	0.21417 (rank : 393)
Query Neighborhood Hits	583	Target Neighborhood Hits	439	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

MTFR1_HUMAN
NC score	0.017185 (rank : 1252)	θ value	3.0926 (rank : 496)
Query Neighborhood Hits	583	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q15390, Q6IB94, Q86XH5, Q8IVD7	Gene names	MTFR1, CHPPR, KIAA0009
Domain Architecture
Description	Mitochondrial fission regulator 1 (Chondrocyte protein with a poly- proline region).

IF35_MOUSE
NC score	0.016779 (rank : 1253)	θ value	6.88961 (rank : 545)
Query Neighborhood Hits	583	Target Neighborhood Hits	210	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

SAM68_HUMAN
NC score	0.016777 (rank : 1254)	θ value	5.27518 (rank : 534)
Query Neighborhood Hits	583	Target Neighborhood Hits	68	Shared Neighborhood Hits	7
SwissProt Accessions	Q07666, Q6PJX7, Q8NB97, Q99760	Gene names	KHDRBS1, SAM68
Domain Architecture	No domain graphic available
Description	KH domain-containing, RNA-binding, signal transduction-associated protein 1 (p21 Ras GTPase-activating protein-associated p62) (GAP- associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p68).

3BP2_MOUSE
NC score	0.016660 (rank : 1255)	θ value	3.0926 (rank : 490)
Query Neighborhood Hits	583	Target Neighborhood Hits	142	Shared Neighborhood Hits	13
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CI106_HUMAN
NC score	0.016518 (rank : 1256)	θ value	5.27518 (rank : 517)
Query Neighborhood Hits	583	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NAJ2	Gene names	C9orf106
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C9orf106.

RIMS1_HUMAN
NC score	0.016068 (rank : 1257)	θ value	0.0431538 (rank : 349)
Query Neighborhood Hits	583	Target Neighborhood Hits	437	Shared Neighborhood Hits	17
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

NFAT5_HUMAN
NC score	0.015303 (rank : 1258)	θ value	1.06291 (rank : 441)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	13
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

PGRP3_HUMAN
NC score	0.015185 (rank : 1259)	θ value	1.06291 (rank : 442)
Query Neighborhood Hits	583	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LB9	Gene names	PGLYRP3, PGRPIA
Domain Architecture
Description	Peptidoglycan recognition protein I-alpha precursor (Peptidoglycan recognition protein intermediate alpha) (PGRP-I-alpha) (PGLYRPIalpha) (Peptidoglycan recognition protein 3).

EVI2B_HUMAN
NC score	0.015110 (rank : 1260)	θ value	4.03905 (rank : 504)
Query Neighborhood Hits	583	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

ERMAP_HUMAN
NC score	0.014876 (rank : 1261)	θ value	8.99809 (rank : 568)
Query Neighborhood Hits	583	Target Neighborhood Hits	155	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

FIP1_HUMAN
NC score	0.014579 (rank : 1262)	θ value	5.27518 (rank : 523)
Query Neighborhood Hits	583	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

POLH_MOUSE
NC score	0.014174 (rank : 1263)	θ value	3.0926 (rank : 497)
Query Neighborhood Hits	583	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJN0, Q9JJJ2	Gene names	Polh, Rad30a, Xpv
Domain Architecture	No domain graphic available
Description	DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein homolog).

CEP68_HUMAN
NC score	0.012613 (rank : 1264)	θ value	4.03905 (rank : 502)
Query Neighborhood Hits	583	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

B4GN3_HUMAN
NC score	0.012577 (rank : 1265)	θ value	0.279714 (rank : 394)
Query Neighborhood Hits	583	Target Neighborhood Hits	128	Shared Neighborhood Hits	13
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

PGCB_MOUSE
NC score	0.011481 (rank : 1266)	θ value	6.88961 (rank : 551)
Query Neighborhood Hits	583	Target Neighborhood Hits	459	Shared Neighborhood Hits	44
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.

K1802_HUMAN
NC score	0.011226 (rank : 1267)	θ value	0.47712 (rank : 410)
Query Neighborhood Hits	583	Target Neighborhood Hits	1378	Shared Neighborhood Hits	69
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

EPN1_HUMAN
NC score	0.011042 (rank : 1268)	θ value	5.27518 (rank : 520)
Query Neighborhood Hits	583	Target Neighborhood Hits	206	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

LV5A_HUMAN
NC score	0.010867 (rank : 1269)	θ value	3.0926 (rank : 495)
Query Neighborhood Hits	583	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	P01719	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-V region DEL.

SIN3A_HUMAN
NC score	0.010426 (rank : 1270)	θ value	5.27518 (rank : 536)
Query Neighborhood Hits	583	Target Neighborhood Hits	180	Shared Neighborhood Hits	18
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

MLL3_MOUSE
NC score	0.009829 (rank : 1271)	θ value	6.88961 (rank : 548)
Query Neighborhood Hits	583	Target Neighborhood Hits	1399	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PGCB_HUMAN
NC score	0.009749 (rank : 1272)	θ value	8.99809 (rank : 576)
Query Neighborhood Hits	583	Target Neighborhood Hits	478	Shared Neighborhood Hits	44
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

LARP1_HUMAN
NC score	0.008390 (rank : 1273)	θ value	8.99809 (rank : 573)
Query Neighborhood Hits	583	Target Neighborhood Hits	242	Shared Neighborhood Hits	16
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

SMAD6_HUMAN
NC score	0.007992 (rank : 1274)	θ value	5.27518 (rank : 537)
Query Neighborhood Hits	583	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

SOX30_HUMAN
NC score	0.007798 (rank : 1275)	θ value	6.88961 (rank : 555)
Query Neighborhood Hits	583	Target Neighborhood Hits	305	Shared Neighborhood Hits	35
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

CCAR1_MOUSE
NC score	0.007538 (rank : 1276)	θ value	2.36792 (rank : 478)
Query Neighborhood Hits	583	Target Neighborhood Hits	414	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

KV5D_MOUSE
NC score	0.007497 (rank : 1277)	θ value	5.27518 (rank : 527)
Query Neighborhood Hits	583	Target Neighborhood Hits	255	Shared Neighborhood Hits	38
SwissProt Accessions	P01636	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 149.

F113A_HUMAN
NC score	0.007390 (rank : 1278)	θ value	8.99809 (rank : 569)
Query Neighborhood Hits	583	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H1Q7, Q5JUA5, Q5JUA6, Q6PK19, Q86WF5, Q96CG7, Q9H1Q6, Q9H6D1	Gene names	FAM113A, C20orf81
Domain Architecture	No domain graphic available
Description	Protein FAM113A (Sarcoma antigen NY-SAR-23).

CREB5_HUMAN
NC score	0.007259 (rank : 1279)	θ value	8.99809 (rank : 566)
Query Neighborhood Hits	583	Target Neighborhood Hits	222	Shared Neighborhood Hits	8
SwissProt Accessions	Q02930, Q05886, Q06246	Gene names	CREB5, CREBPA
Domain Architecture
Description	cAMP response element-binding protein 5 (CRE-BPa).

KCNQ4_HUMAN
NC score	0.007043 (rank : 1280)	θ value	1.06291 (rank : 437)
Query Neighborhood Hits	583	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

UBQL4_MOUSE
NC score	0.006841 (rank : 1281)	θ value	0.62314 (rank : 423)
Query Neighborhood Hits	583	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q99NB8, Q8BP88	Gene names	Ubqln4, Ubin
Domain Architecture
Description	Ubiquilin-4 (Ataxin-1 ubiquitin-like-interacting protein A1U).

MKL2_MOUSE
NC score	0.006017 (rank : 1282)	θ value	8.99809 (rank : 574)
Query Neighborhood Hits	583	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

LDB3_MOUSE
NC score	0.005900 (rank : 1283)	θ value	1.06291 (rank : 439)
Query Neighborhood Hits	583	Target Neighborhood Hits	510	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

CNOT4_HUMAN
NC score	0.005552 (rank : 1284)	θ value	5.27518 (rank : 518)
Query Neighborhood Hits	583	Target Neighborhood Hits	207	Shared Neighborhood Hits	20
SwissProt Accessions	O95628, O95339, O95627, Q8IYM7, Q8NCL0, Q9NPQ1, Q9NZN6	Gene names	CNOT4, NOT4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

US6NL_HUMAN
NC score	0.005187 (rank : 1285)	θ value	6.88961 (rank : 557)
Query Neighborhood Hits	583	Target Neighborhood Hits	201	Shared Neighborhood Hits	18
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

AFF4_MOUSE
NC score	0.005140 (rank : 1286)	θ value	8.99809 (rank : 563)
Query Neighborhood Hits	583	Target Neighborhood Hits	581	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

BRD3_HUMAN
NC score	0.004971 (rank : 1287)	θ value	6.88961 (rank : 541)
Query Neighborhood Hits	583	Target Neighborhood Hits	369	Shared Neighborhood Hits	24
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

NP1L3_HUMAN
NC score	0.004708 (rank : 1288)	θ value	4.03905 (rank : 510)
Query Neighborhood Hits	583	Target Neighborhood Hits	172	Shared Neighborhood Hits	8
SwissProt Accessions	Q99457, O60788	Gene names	NAP1L3, BNAP
Domain Architecture
Description	Nucleosome assembly protein 1-like 3.

CUTL2_MOUSE
NC score	0.004326 (rank : 1289)	θ value	8.99809 (rank : 567)
Query Neighborhood Hits	583	Target Neighborhood Hits	771	Shared Neighborhood Hits	27
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

SCYB5_MOUSE
NC score	0.004297 (rank : 1290)	θ value	8.99809 (rank : 580)
Query Neighborhood Hits	583	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	P50228	Gene names	Cxcl5, Scyb5
Domain Architecture
Description	Small inducible cytokine B5 precursor (CXCL5) (Cytokine LIX) [Contains: GCP-2(1-78); GCP-2(9-78)].

HCN2_MOUSE
NC score	0.004211 (rank : 1291)	θ value	3.0926 (rank : 494)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	23
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

TACC2_MOUSE
NC score	0.004075 (rank : 1292)	θ value	6.88961 (rank : 556)
Query Neighborhood Hits	583	Target Neighborhood Hits	774	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

BCOR_MOUSE
NC score	0.004061 (rank : 1293)	θ value	0.0961366 (rank : 362)
Query Neighborhood Hits	583	Target Neighborhood Hits	521	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

KV1M_HUMAN
NC score	0.003955 (rank : 1294)	θ value	2.36792 (rank : 482)
Query Neighborhood Hits	583	Target Neighborhood Hits	249	Shared Neighborhood Hits	29
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

LDB3_HUMAN
NC score	0.003946 (rank : 1295)	θ value	4.03905 (rank : 509)
Query Neighborhood Hits	583	Target Neighborhood Hits	497	Shared Neighborhood Hits	35
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

TACC3_HUMAN
NC score	0.003497 (rank : 1296)	θ value	1.06291 (rank : 446)
Query Neighborhood Hits	583	Target Neighborhood Hits	779	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

UN13A_HUMAN
NC score	0.003492 (rank : 1297)	θ value	2.36792 (rank : 488)
Query Neighborhood Hits	583	Target Neighborhood Hits	285	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

XRN1_MOUSE
NC score	0.003467 (rank : 1298)	θ value	6.88961 (rank : 560)
Query Neighborhood Hits	583	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	P97789, O35651, P97790, Q3TE44, Q3TRE9, Q3UQL5	Gene names	Xrn1, Dhm2, Exo, Sep1
Domain Architecture	No domain graphic available
Description	5'-3' exoribonuclease 1 (EC 3.1.11.-) (mXRN1) (Strand-exchange protein 1 homolog) (Protein Dhm2).

KV1H_HUMAN
NC score	0.002996 (rank : 1299)	θ value	5.27518 (rank : 526)
Query Neighborhood Hits	583	Target Neighborhood Hits	283	Shared Neighborhood Hits	29
SwissProt Accessions	P01600	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Hau.

BCOR_HUMAN
NC score	0.002894 (rank : 1300)	θ value	8.99809 (rank : 564)
Query Neighborhood Hits	583	Target Neighborhood Hits	609	Shared Neighborhood Hits	40
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

P3C2A_HUMAN
NC score	0.002691 (rank : 1301)	θ value	5.27518 (rank : 529)
Query Neighborhood Hits	583	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

ESX1L_HUMAN
NC score	0.002301 (rank : 1302)	θ value	3.0926 (rank : 493)
Query Neighborhood Hits	583	Target Neighborhood Hits	498	Shared Neighborhood Hits	24
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

VPREB_HUMAN
NC score	0.000950 (rank : 1303)	θ value	6.88961 (rank : 558)
Query Neighborhood Hits	583	Target Neighborhood Hits	278	Shared Neighborhood Hits	19
SwissProt Accessions	P12018	Gene names	VPREB1, VPREB
Domain Architecture
Description	Immunoglobulin iota chain precursor (V(pre)B protein) (VpreB protein) (CD179a antigen).

FRM4B_MOUSE
NC score	-0.000651 (rank : 1304)	θ value	4.03905 (rank : 507)
Query Neighborhood Hits	583	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q920B0, Q3V1S1, Q9ESP9	Gene names	Frmd4b
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 4B (GRP1-binding protein GRSP1) (Golgi- associated band 4.1-like protein) (GOBLIN).

HECD2_HUMAN
NC score	-0.001001 (rank : 1305)	θ value	6.88961 (rank : 544)
Query Neighborhood Hits	583	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

VPRE2_MOUSE
NC score	-0.001213 (rank : 1306)	θ value	8.99809 (rank : 583)
Query Neighborhood Hits	583	Target Neighborhood Hits	281	Shared Neighborhood Hits	18
SwissProt Accessions	P13373	Gene names	Vpreb2
Domain Architecture
Description	Immunoglobulin omega chain precursor (VpreB2 protein).

ZF106_MOUSE
NC score	-0.001336 (rank : 1307)	θ value	3.0926 (rank : 500)
Query Neighborhood Hits	583	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

IC1_MOUSE
NC score	-0.003085 (rank : 1308)	θ value	8.99809 (rank : 572)
Query Neighborhood Hits	583	Target Neighborhood Hits	164	Shared Neighborhood Hits	14
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

DSG1C_MOUSE
NC score	-0.003277 (rank : 1309)	θ value	2.36792 (rank : 479)
Query Neighborhood Hits	583	Target Neighborhood Hits	156	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TSF0, Q7TQ61	Gene names	Dsg1c, Dsg6
Domain Architecture	No domain graphic available
Description	Desmoglein-1 gamma precursor (Dsg1-gamma) (Desmoglein-6).

PCDA5_HUMAN
NC score	-0.003786 (rank : 1310)	θ value	2.36792 (rank : 484)
Query Neighborhood Hits	583	Target Neighborhood Hits	217	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

PCDA8_HUMAN
NC score	-0.004069 (rank : 1311)	θ value	5.27518 (rank : 531)
Query Neighborhood Hits	583	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y5H6, O75281	Gene names	PCDHA8
Domain Architecture
Description	Protocadherin alpha 8 precursor (PCDH-alpha8).

PCDA2_HUMAN
NC score	-0.004073 (rank : 1312)	θ value	5.27518 (rank : 530)
Query Neighborhood Hits	583	Target Neighborhood Hits	192	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

BRCA1_HUMAN
NC score	-0.004253 (rank : 1313)	θ value	8.99809 (rank : 565)
Query Neighborhood Hits	583	Target Neighborhood Hits	381	Shared Neighborhood Hits	10
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

ZEP1_MOUSE
NC score	-0.006731 (rank : 1314)	θ value	2.36792 (rank : 489)
Query Neighborhood Hits	583	Target Neighborhood Hits	1063	Shared Neighborhood Hits	40
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

EGR2_MOUSE
NC score	-0.014085 (rank : 1315)	θ value	6.88961 (rank : 543)
Query Neighborhood Hits	583	Target Neighborhood Hits	745	Shared Neighborhood Hits	12
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).