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Network neighborhood for query Sequence : 3BP2_MOUSE

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3BP2_MOUSE
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

3BP2_HUMAN
θ value	0 (rank : 1)	NC score	0.925478 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	296	Shared Neighborhood Hits	90
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA6_MOUSE
θ value	3.77169e-06 (rank : 3)	NC score	0.335844 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	591	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
θ value	8.40245e-06 (rank : 4)	NC score	0.332329 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	556	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

MUC1_HUMAN
θ value	3.19293e-05 (rank : 5)	NC score	0.074271 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	975	Shared Neighborhood Hits	36
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

RHG25_MOUSE
θ value	9.29e-05 (rank : 6)	NC score	0.213846 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	492	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH3_HUMAN
θ value	0.000461057 (rank : 7)	NC score	0.276988 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

RHG25_HUMAN
θ value	0.000461057 (rank : 8)	NC score	0.207434 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	550	Shared Neighborhood Hits	45
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CYH3_MOUSE
θ value	0.000786445 (rank : 9)	NC score	0.276432 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	40
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

PKHA5_HUMAN
θ value	0.00102713 (rank : 10)	NC score	0.264627 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	455	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH1_HUMAN
θ value	0.00134147 (rank : 11)	NC score	0.274455 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	184	Shared Neighborhood Hits	42
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.00134147 (rank : 12)	NC score	0.273399 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH4_HUMAN
θ value	0.00134147 (rank : 13)	NC score	0.275152 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
θ value	0.00134147 (rank : 14)	NC score	0.274777 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

PLEK2_MOUSE
θ value	0.00298849 (rank : 15)	NC score	0.283275 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CYH2_HUMAN
θ value	0.00390308 (rank : 16)	NC score	0.268271 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.00390308 (rank : 17)	NC score	0.268232 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	171	Shared Neighborhood Hits	40
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHA4_HUMAN
θ value	0.00390308 (rank : 18)	NC score	0.303610 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA1_HUMAN
θ value	0.00509761 (rank : 19)	NC score	0.267033 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	0.00509761 (rank : 20)	NC score	0.266448 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_HUMAN
θ value	0.00509761 (rank : 21)	NC score	0.294132 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK2_HUMAN
θ value	0.00869519 (rank : 22)	NC score	0.278018 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PKHA4_MOUSE
θ value	0.0113563 (rank : 23)	NC score	0.304326 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	202	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.250722 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NFH_MOUSE
θ value	0.0148317 (rank : 25)	NC score	0.051390 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	2247	Shared Neighborhood Hits	60
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PRRT3_HUMAN
θ value	0.0148317 (rank : 26)	NC score	0.102601 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	998	Shared Neighborhood Hits	45
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SAPS1_HUMAN
θ value	0.0148317 (rank : 27)	NC score	0.091791 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CSK_MOUSE
θ value	0.0193708 (rank : 28)	NC score	0.045613 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

MYO10_HUMAN
θ value	0.0193708 (rank : 29)	NC score	0.072023 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	920	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

APS_HUMAN
θ value	0.0252991 (rank : 30)	NC score	0.145914 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	29
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

DAPP1_MOUSE
θ value	0.0252991 (rank : 31)	NC score	0.253737 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MATK_HUMAN
θ value	0.0252991 (rank : 32)	NC score	0.044595 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	954	Shared Neighborhood Hits	34
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

PLEK_MOUSE
θ value	0.0252991 (rank : 33)	NC score	0.280733 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PRGC2_HUMAN
θ value	0.0252991 (rank : 34)	NC score	0.113391 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

APS_MOUSE
θ value	0.0330416 (rank : 35)	NC score	0.141186 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

MATK_MOUSE
θ value	0.0330416 (rank : 36)	NC score	0.043738 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	952	Shared Neighborhood Hits	33
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

CSK_HUMAN
θ value	0.0431538 (rank : 37)	NC score	0.044291 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

RASA1_HUMAN
θ value	0.0431538 (rank : 38)	NC score	0.167154 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

FARP1_HUMAN
θ value	0.0736092 (rank : 39)	NC score	0.105323 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	241	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ZN318_MOUSE
θ value	0.0736092 (rank : 40)	NC score	0.055914 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	642	Shared Neighborhood Hits	15
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

P55G_MOUSE
θ value	0.0961366 (rank : 41)	NC score	0.121779 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	401	Shared Neighborhood Hits	28
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
θ value	0.125558 (rank : 42)	NC score	0.117672 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	28
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

TARSH_HUMAN
θ value	0.125558 (rank : 43)	NC score	0.090331 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	768	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

BLNK_HUMAN
θ value	0.163984 (rank : 44)	NC score	0.102475 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

GNRP_HUMAN
θ value	0.163984 (rank : 45)	NC score	0.127276 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

STAT2_MOUSE
θ value	0.163984 (rank : 46)	NC score	0.037393 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

CASC3_MOUSE
θ value	0.21417 (rank : 47)	NC score	0.061105 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	333	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CS007_MOUSE
θ value	0.21417 (rank : 48)	NC score	0.074855 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	464	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DCC_MOUSE
θ value	0.279714 (rank : 49)	NC score	0.020650 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

FARP2_MOUSE
θ value	0.279714 (rank : 50)	NC score	0.103099 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

P85A_HUMAN
θ value	0.279714 (rank : 51)	NC score	0.117296 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	479	Shared Neighborhood Hits	34
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

FGR_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.038449 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	1067	Shared Neighborhood Hits	38
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGD4_MOUSE
θ value	0.47712 (rank : 53)	NC score	0.076700 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

TP53B_MOUSE
θ value	0.47712 (rank : 54)	NC score	0.052560 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	644	Shared Neighborhood Hits	27
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

CK024_HUMAN
θ value	0.62314 (rank : 55)	NC score	0.075304 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	408	Shared Neighborhood Hits	26
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

I12R2_HUMAN
θ value	0.62314 (rank : 56)	NC score	0.027790 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

LTBP4_MOUSE
θ value	0.62314 (rank : 57)	NC score	0.017873 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	607	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

M3K9_HUMAN
θ value	0.62314 (rank : 58)	NC score	0.023155 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	25
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MAP2_HUMAN
θ value	0.62314 (rank : 59)	NC score	0.048339 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	348	Shared Neighborhood Hits	18
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

P85A_MOUSE
θ value	0.62314 (rank : 60)	NC score	0.114789 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BLK_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.032481 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	994	Shared Neighborhood Hits	33
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MLL3_HUMAN
θ value	0.813845 (rank : 62)	NC score	0.044927 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	1644	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ALEX_MOUSE
θ value	1.06291 (rank : 63)	NC score	0.055331 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

CENG3_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.043011 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	467	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

ETV3_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.034264 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	17
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

FARP2_HUMAN
θ value	1.06291 (rank : 66)	NC score	0.093344 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD1_MOUSE
θ value	1.06291 (rank : 67)	NC score	0.089140 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	45
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GNRP_MOUSE
θ value	1.06291 (rank : 68)	NC score	0.118238 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	42
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SLAP2_MOUSE
θ value	1.06291 (rank : 69)	NC score	0.078667 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

FA47B_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.080181 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	431	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

LRC56_HUMAN
θ value	1.38821 (rank : 71)	NC score	0.041760 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	165	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

TNIK_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.012704 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	1570	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

AAK1_HUMAN
θ value	1.81305 (rank : 73)	NC score	0.023671 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	1077	Shared Neighborhood Hits	39
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ALMS1_MOUSE
θ value	1.81305 (rank : 74)	NC score	0.030837 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

CEND2_HUMAN
θ value	1.81305 (rank : 75)	NC score	0.090210 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

DGKK_HUMAN
θ value	1.81305 (rank : 76)	NC score	0.067773 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

GP1BA_HUMAN
θ value	1.81305 (rank : 77)	NC score	0.017668 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	407	Shared Neighborhood Hits	14
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

NCOA6_HUMAN
θ value	1.81305 (rank : 78)	NC score	0.048685 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	1202	Shared Neighborhood Hits	47
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SON_MOUSE
θ value	1.81305 (rank : 79)	NC score	0.053092 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	957	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

VAV2_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.071394 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CBX2_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.030262 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

MBD5_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.037529 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

BRD4_MOUSE
θ value	3.0926 (rank : 83)	NC score	0.043519 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CENG3_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.038830 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DCC_HUMAN
θ value	3.0926 (rank : 85)	NC score	0.016660 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	583	Shared Neighborhood Hits	13
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

FGD1_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.082388 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	367	Shared Neighborhood Hits	39
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.068505 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

MILK1_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.044888 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	788	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MTR1L_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.007656 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	1180	Shared Neighborhood Hits	16
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

PLCG2_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.071956 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	280	Shared Neighborhood Hits	30
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

RIN3_HUMAN
θ value	3.0926 (rank : 91)	NC score	0.051938 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

SF04_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.033828 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CH02, Q8R094	Gene names	Sf4
Domain Architecture	No domain graphic available
Description	Splicing factor 4.

ZN628_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.002250 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	814	Shared Neighborhood Hits	18
SwissProt Accessions	Q5EBL2, Q86X34	Gene names	ZNF628
Domain Architecture	No domain graphic available
Description	Zinc finger protein 628.

BLK_MOUSE
θ value	4.03905 (rank : 94)	NC score	0.028744 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	992	Shared Neighborhood Hits	33
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_MOUSE
θ value	4.03905 (rank : 95)	NC score	0.090557 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CENG2_HUMAN
θ value	4.03905 (rank : 96)	NC score	0.036526 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	471	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

FGD6_HUMAN
θ value	4.03905 (rank : 97)	NC score	0.077773 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GR65_MOUSE
θ value	4.03905 (rank : 98)	NC score	0.028600 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

HEM1_MOUSE
θ value	4.03905 (rank : 99)	NC score	0.014905 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

IC1_MOUSE
θ value	4.03905 (rank : 100)	NC score	0.008823 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	164	Shared Neighborhood Hits	7
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

KS6A4_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.008312 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	868	Shared Neighborhood Hits	16
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

PLCG1_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.066814 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

TPX2_HUMAN
θ value	4.03905 (rank : 103)	NC score	0.032294 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

UBP8_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.008737 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	751	Shared Neighborhood Hits	9
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

BAT2_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.062451 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	931	Shared Neighborhood Hits	38
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CENG1_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.042201 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	544	Shared Neighborhood Hits	27
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	5.27518 (rank : 107)	NC score	0.044848 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	531	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CSKI1_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.030756 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	997	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI2_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.027729 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	747	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

E41L1_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.027363 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

EHMT2_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.011068 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	750	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

FA47A_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.046971 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GR65_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.038139 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

MPP6_MOUSE
θ value	5.27518 (rank : 114)	NC score	0.008302 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

PLCG1_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.066423 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	34
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RP1L1_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.032474 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	1072	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SIP1_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.000720 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

SON_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.050001 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	1568	Shared Neighborhood Hits	59
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPEG_MOUSE
θ value	5.27518 (rank : 119)	NC score	0.023639 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	1959	Shared Neighborhood Hits	57
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZN473_MOUSE
θ value	5.27518 (rank : 120)	NC score	-0.001198 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	824	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BI67, Q8BI98, Q8BIB7	Gene names	Znf473, Zfp100, Zfp473
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 homolog (Zinc finger protein 100) (Zfp-100).

AGT2_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.031451 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYV1, Q53FB4, Q53FY7, Q53G03, Q5W7Q1	Gene names	AGXT2, AGT2
Domain Architecture
Description	Alanine--glyoxylate aminotransferase 2, mitochondrial precursor (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (AGT 2) (Beta-alanine-pyruvate aminotransferase) (Beta- ALAAT II) (D-AIBAT).

BTBDC_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.025692 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CEND3_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.069203 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	275	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

E41L1_HUMAN
θ value	6.88961 (rank : 124)	NC score	0.027557 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

GLI2_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.002152 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	971	Shared Neighborhood Hits	17
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

HSF4_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.012696 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0L1, Q9R0L2	Gene names	Hsf4
Domain Architecture
Description	Heat shock factor protein 4 (HSF 4) (Heat shock transcription factor 4) (HSTF 4) (mHSF4).

NACAM_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.051116 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	1866	Shared Neighborhood Hits	60
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

P85B_HUMAN
θ value	6.88961 (rank : 128)	NC score	0.092765 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	6.88961 (rank : 129)	NC score	0.095097 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	519	Shared Neighborhood Hits	31
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PLXB1_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.020865 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

SELPL_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.045056 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	588	Shared Neighborhood Hits	33
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

STAR8_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.029874 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

VAV2_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.065816 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	453	Shared Neighborhood Hits	40
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ZN551_HUMAN
θ value	6.88961 (rank : 134)	NC score	-0.001749 (rank : 236)
Query Neighborhood Hits	142	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z340, P17034, Q8N246, Q9BRY1	Gene names	ZNF551, KOX23
Domain Architecture	No domain graphic available
Description	Zinc finger protein 551 (Zinc finger protein KOX23).

BMX_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.036500 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CENA2_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.069915 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CEND3_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.065142 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

KCC1G_MOUSE
θ value	8.99809 (rank : 138)	NC score	0.008343 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	851	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

PRAX_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.026724 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	215	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRR3_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.034094 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	P79522, Q5RJB5	Gene names	PRR3, CAT56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

RGS3_MOUSE
θ value	8.99809 (rank : 141)	NC score	0.036704 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	1621	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SPEG_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.020643 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	1762	Shared Neighborhood Hits	51
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

3BP1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.058802 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AB1IP_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.055107 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

ANLN_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.074741 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.060304 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

BIG1_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.110450 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.111468 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

C43BP_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.051510 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	91	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CDN1C_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.054825 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CENA1_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.069312 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENB1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.065622 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	383	Shared Neighborhood Hits	43
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.081469 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	425	Shared Neighborhood Hits	44
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.072894 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	395	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CEND1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.066428 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.054505 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	260	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CHIN_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.050169 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CN155_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.052477 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	27
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CNKR1_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.144137 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	154	Shared Neighborhood Hits	33
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.104944 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.105088 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DGKH_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.060014 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	39
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

FBX8_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.102788 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

FBX8_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.103207 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FGD2_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.052511 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.054391 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.055588 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.065708 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.064954 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.071863 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GAB1_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.059547 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	279	Shared Neighborhood Hits	29
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.051984 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	233	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB2_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.050287 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GAB2_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.054283 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GBF1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.112613 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

GGN_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.064556 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GGN_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.070117 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRAP2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.050679 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	304	Shared Neighborhood Hits	28
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.054818 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.056407 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	31
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.057190 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	30
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.057133 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GSCR1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.052770 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	674	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

IQEC1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.097562 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.096156 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.102661 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	403	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.102915 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	417	Shared Neighborhood Hits	32
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC3_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.108574 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.109061 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	28
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

LCP2_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.073829 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.068689 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.068945 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	23
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MBD6_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.059826 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MUC1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.063164 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	388	Shared Neighborhood Hits	17
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUC7_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.061502 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	538	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCK2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.053363 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

OSBP1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.052661 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	180	Shared Neighborhood Hits	34
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PHLB1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.054118 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	678	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA2_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.187264 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.190205 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHB1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.062077 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.054054 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.076866 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.082621 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PRG4_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.068475 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	764	Shared Neighborhood Hits	40
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.051181 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.066977 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.070407 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	347	Shared Neighborhood Hits	29
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR12_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.075093 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

PSD3_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.126674 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.112641 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.106412 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RAPH1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.058903 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	593	Shared Neighborhood Hits	48
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SELV_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.054067 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

SET1A_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.058758 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	690	Shared Neighborhood Hits	36
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SH21B_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.052623 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	14
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.056681 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	15
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHD_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.050766 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SLAP1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.054961 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	23
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.055993 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	117	Shared Neighborhood Hits	23
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.062746 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SRRM1_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.064034 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	690	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.055159 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	966	Shared Neighborhood Hits	45
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SWP70_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.068723 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	973	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.065249 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	1097	Shared Neighborhood Hits	38
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TAF4_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.053734 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	687	Shared Neighborhood Hits	34
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARA_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.051525 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	1133	Shared Neighborhood Hits	53
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

VAV3_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.058565 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	398	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.059814 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	404	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.050231 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	452	Shared Neighborhood Hits	33
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

WASIP_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.070100 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	458	Shared Neighborhood Hits	34
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.053185 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WASL_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.050615 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WBP11_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.051984 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	354	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.050732 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	362	Shared Neighborhood Hits	21
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

YLPM1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.061640 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

Hits sorted by NC score

3BP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.925478 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	296	Shared Neighborhood Hits	90
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA6_MOUSE
NC score	0.335844 (rank : 3)	θ value	3.77169e-06 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	591	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
NC score	0.332329 (rank : 4)	θ value	8.40245e-06 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	556	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA4_MOUSE
NC score	0.304326 (rank : 5)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	202	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.303610 (rank : 6)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	283	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PLEK_HUMAN
NC score	0.294132 (rank : 7)	θ value	0.00509761 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK2_MOUSE
NC score	0.283275 (rank : 8)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	96	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_MOUSE
NC score	0.280733 (rank : 9)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLEK2_HUMAN
NC score	0.278018 (rank : 10)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CYH3_HUMAN
NC score	0.276988 (rank : 11)	θ value	0.000461057 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
NC score	0.276432 (rank : 12)	θ value	0.000786445 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	40
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
NC score	0.275152 (rank : 13)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.274777 (rank : 14)	θ value	0.00134147 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_HUMAN
NC score	0.274455 (rank : 15)	θ value	0.00134147 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	184	Shared Neighborhood Hits	42
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.273399 (rank : 16)	θ value	0.00134147 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH2_HUMAN
NC score	0.268271 (rank : 17)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.268232 (rank : 18)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	171	Shared Neighborhood Hits	40
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHA1_HUMAN
NC score	0.267033 (rank : 19)	θ value	0.00509761 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.266448 (rank : 20)	θ value	0.00509761 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	120	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA5_HUMAN
NC score	0.264627 (rank : 21)	θ value	0.00102713 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	455	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

DAPP1_MOUSE
NC score	0.253737 (rank : 22)	θ value	0.0252991 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	225	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.250722 (rank : 23)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

RHG25_MOUSE
NC score	0.213846 (rank : 24)	θ value	9.29e-05 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	492	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.207434 (rank : 25)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	550	Shared Neighborhood Hits	45
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA2_MOUSE
NC score	0.190205 (rank : 26)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA2_HUMAN
NC score	0.187264 (rank : 27)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RASA1_HUMAN
NC score	0.167154 (rank : 28)	θ value	0.0431538 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

APS_HUMAN
NC score	0.145914 (rank : 29)	θ value	0.0252991 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	29
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CNKR1_HUMAN
NC score	0.144137 (rank : 30)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	154	Shared Neighborhood Hits	33
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

APS_MOUSE
NC score	0.141186 (rank : 31)	θ value	0.0330416 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GNRP_HUMAN
NC score	0.127276 (rank : 32)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	239	Shared Neighborhood Hits	37
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PSD3_HUMAN
NC score	0.126674 (rank : 33)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

P55G_MOUSE
NC score	0.121779 (rank : 34)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	401	Shared Neighborhood Hits	28
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GNRP_MOUSE
NC score	0.118238 (rank : 35)	θ value	1.06291 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	42
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

P55G_HUMAN
NC score	0.117672 (rank : 36)	θ value	0.125558 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	28
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
NC score	0.117296 (rank : 37)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	479	Shared Neighborhood Hits	34
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.114789 (rank : 38)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PRGC2_HUMAN
NC score	0.113391 (rank : 39)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	272	Shared Neighborhood Hits	17
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

PSD4_HUMAN
NC score	0.112641 (rank : 40)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

GBF1_HUMAN
NC score	0.112613 (rank : 41)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	12
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG2_HUMAN
NC score	0.111468 (rank : 42)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.110450 (rank : 43)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

IQEC3_MOUSE
NC score	0.109061 (rank : 44)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	28
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC3_HUMAN
NC score	0.108574 (rank : 45)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

PSD4_MOUSE
NC score	0.106412 (rank : 46)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	78	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

FARP1_HUMAN
NC score	0.105323 (rank : 47)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	241	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

CNKR2_MOUSE
NC score	0.105088 (rank : 48)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.104944 (rank : 49)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

FBX8_MOUSE
NC score	0.103207 (rank : 50)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	45	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FARP2_MOUSE
NC score	0.103099 (rank : 51)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

IQEC2_MOUSE
NC score	0.102915 (rank : 52)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	417	Shared Neighborhood Hits	32
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

FBX8_HUMAN
NC score	0.102788 (rank : 53)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

IQEC2_HUMAN
NC score	0.102661 (rank : 54)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	403	Shared Neighborhood Hits	30
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

PRRT3_HUMAN
NC score	0.102601 (rank : 55)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	998	Shared Neighborhood Hits	45
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

BLNK_HUMAN
NC score	0.102475 (rank : 56)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

IQEC1_HUMAN
NC score	0.097562 (rank : 57)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC1_MOUSE
NC score	0.096156 (rank : 58)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

P85B_MOUSE
NC score	0.095097 (rank : 59)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	519	Shared Neighborhood Hits	31
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FARP2_HUMAN
NC score	0.093344 (rank : 60)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

P85B_HUMAN
NC score	0.092765 (rank : 61)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	543	Shared Neighborhood Hits	31
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SAPS1_HUMAN
NC score	0.091791 (rank : 62)	θ value	0.0148317 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	704	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

BLNK_MOUSE
NC score	0.090557 (rank : 63)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TARSH_HUMAN
NC score	0.090331 (rank : 64)	θ value	0.125558 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	768	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

CEND2_HUMAN
NC score	0.090210 (rank : 65)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	166	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

FGD1_MOUSE
NC score	0.089140 (rank : 66)	θ value	1.06291 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	45
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

PKHB2_MOUSE
NC score	0.082621 (rank : 67)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

FGD1_HUMAN
NC score	0.082388 (rank : 68)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	367	Shared Neighborhood Hits	39
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CENB2_HUMAN
NC score	0.081469 (rank : 69)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	425	Shared Neighborhood Hits	44
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

FA47B_HUMAN
NC score	0.080181 (rank : 70)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	431	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

SLAP2_MOUSE
NC score	0.078667 (rank : 71)	θ value	1.06291 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

FGD6_HUMAN
NC score	0.077773 (rank : 72)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	237	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHB2_HUMAN
NC score	0.076866 (rank : 73)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

FGD4_MOUSE
NC score	0.076700 (rank : 74)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

CK024_HUMAN
NC score	0.075304 (rank : 75)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	408	Shared Neighborhood Hits	26
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

PRR12_HUMAN
NC score	0.075093 (rank : 76)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	460	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

CS007_MOUSE
NC score	0.074855 (rank : 77)	θ value	0.21417 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	464	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

ANLN_HUMAN
NC score	0.074741 (rank : 78)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

MUC1_HUMAN
NC score	0.074271 (rank : 79)	θ value	3.19293e-05 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	975	Shared Neighborhood Hits	36
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

LCP2_HUMAN
NC score	0.073829 (rank : 80)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	531	Shared Neighborhood Hits	40
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CENB5_HUMAN
NC score	0.072894 (rank : 81)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	395	Shared Neighborhood Hits	39
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

MYO10_HUMAN
NC score	0.072023 (rank : 82)	θ value	0.0193708 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	920	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

PLCG2_HUMAN
NC score	0.071956 (rank : 83)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	280	Shared Neighborhood Hits	30
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

FGD6_MOUSE
NC score	0.071863 (rank : 84)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

VAV2_MOUSE
NC score	0.071394 (rank : 85)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PRP2_MOUSE
NC score	0.070407 (rank : 86)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	347	Shared Neighborhood Hits	29
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

GGN_MOUSE
NC score	0.070117 (rank : 87)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	311	Shared Neighborhood Hits	35
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

WASIP_HUMAN
NC score	0.070100 (rank : 88)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	458	Shared Neighborhood Hits	34
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

CENA2_HUMAN
NC score	0.069915 (rank : 89)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA1_HUMAN
NC score	0.069312 (rank : 90)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CEND3_HUMAN
NC score	0.069203 (rank : 91)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	275	Shared Neighborhood Hits	48
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

LNK_MOUSE
NC score	0.068945 (rank : 92)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	23
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SWP70_HUMAN
NC score	0.068723 (rank : 93)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	973	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

LNK_HUMAN
NC score	0.068689 (rank : 94)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGD4_HUMAN
NC score	0.068505 (rank : 95)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	26
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PRG4_HUMAN
NC score	0.068475 (rank : 96)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	764	Shared Neighborhood Hits	40
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

DGKK_HUMAN
NC score	0.067773 (rank : 97)	θ value	1.81305 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

PRP1_HUMAN
NC score	0.066977 (rank : 98)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PLCG1_HUMAN
NC score	0.066814 (rank : 99)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CEND1_HUMAN
NC score	0.066428 (rank : 100)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PLCG1_MOUSE
NC score	0.066423 (rank : 101)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	314	Shared Neighborhood Hits	34
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV2_HUMAN
NC score	0.065816 (rank : 102)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	453	Shared Neighborhood Hits	40
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FGD5_HUMAN
NC score	0.065708 (rank : 103)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

CENB1_HUMAN
NC score	0.065622 (rank : 104)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	383	Shared Neighborhood Hits	43
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

SWP70_MOUSE
NC score	0.065249 (rank : 105)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	1097	Shared Neighborhood Hits	38
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CEND3_MOUSE
NC score	0.065142 (rank : 106)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	228	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

FGD5_MOUSE
NC score	0.064954 (rank : 107)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GGN_HUMAN
NC score	0.064556 (rank : 108)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	269	Shared Neighborhood Hits	23
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

SRRM1_HUMAN
NC score	0.064034 (rank : 109)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	690	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

MUC1_MOUSE
NC score	0.063164 (rank : 110)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	388	Shared Neighborhood Hits	17
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

SLAP2_HUMAN
NC score	0.062746 (rank : 111)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

BAT2_HUMAN
NC score	0.062451 (rank : 112)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	931	Shared Neighborhood Hits	38
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PKHB1_HUMAN
NC score	0.062077 (rank : 113)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

YLPM1_MOUSE
NC score	0.061640 (rank : 114)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	142	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

MUC7_HUMAN
NC score	0.061502 (rank : 115)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	538	Shared Neighborhood Hits	33
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

CASC3_MOUSE
NC score	0.061105 (rank : 116)	θ value	0.21417 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	333	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

ANLN_MOUSE
NC score	0.060304 (rank : 117)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

DGKH_HUMAN
NC score	0.060014 (rank : 118)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	39
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MBD6_HUMAN
NC score	0.059826 (rank : 119)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	349	Shared Neighborhood Hits	23
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

VAV3_MOUSE
NC score	0.059814 (rank : 120)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	404	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GAB1_HUMAN
NC score	0.059547 (rank : 121)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	279	Shared Neighborhood Hits	29
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

RAPH1_HUMAN
NC score	0.058903 (rank : 122)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	593	Shared Neighborhood Hits	48
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

3BP1_HUMAN
NC score	0.058802 (rank : 123)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	376	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SET1A_HUMAN
NC score	0.058758 (rank : 124)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	690	Shared Neighborhood Hits	36
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

VAV3_HUMAN
NC score	0.058565 (rank : 125)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	398	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

GRB2_HUMAN
NC score	0.057190 (rank : 126)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	30
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.057133 (rank : 127)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH21B_MOUSE
NC score	0.056681 (rank : 128)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	15
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GRAP_MOUSE
NC score	0.056407 (rank : 129)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	309	Shared Neighborhood Hits	31
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SLAP1_MOUSE
NC score	0.055993 (rank : 130)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	117	Shared Neighborhood Hits	23
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

ZN318_MOUSE
NC score	0.055914 (rank : 131)	θ value	0.0736092 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	642	Shared Neighborhood Hits	15
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

FGD3_MOUSE
NC score	0.055588 (rank : 132)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ALEX_MOUSE
NC score	0.055331 (rank : 133)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	16
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

SRRM1_MOUSE
NC score	0.055159 (rank : 134)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	966	Shared Neighborhood Hits	45
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

AB1IP_HUMAN
NC score	0.055107 (rank : 135)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

SLAP1_HUMAN
NC score	0.054961 (rank : 136)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	23
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

CDN1C_HUMAN
NC score	0.054825 (rank : 137)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	P49918	Gene names	CDKN1C, KIP2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

GRAP_HUMAN
NC score	0.054818 (rank : 138)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	30
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CEND1_MOUSE
NC score	0.054505 (rank : 139)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	260	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

FGD2_MOUSE
NC score	0.054391 (rank : 140)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

GAB2_MOUSE
NC score	0.054283 (rank : 141)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PHLB1_MOUSE
NC score	0.054118 (rank : 142)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	678	Shared Neighborhood Hits	42
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SELV_HUMAN
NC score	0.054067 (rank : 143)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

PKHB1_MOUSE
NC score	0.054054 (rank : 144)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

TAF4_HUMAN
NC score	0.053734 (rank : 145)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	687	Shared Neighborhood Hits	34
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

NCK2_HUMAN
NC score	0.053363 (rank : 146)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	310	Shared Neighborhood Hits	29
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

WASIP_MOUSE
NC score	0.053185 (rank : 147)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	392	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

SON_MOUSE
NC score	0.053092 (rank : 148)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	957	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

GSCR1_HUMAN
NC score	0.052770 (rank : 149)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	674	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

OSBP1_HUMAN
NC score	0.052661 (rank : 150)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	180	Shared Neighborhood Hits	34
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

SH21B_HUMAN
NC score	0.052623 (rank : 151)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	14
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TP53B_MOUSE
NC score	0.052560 (rank : 152)	θ value	0.47712 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	644	Shared Neighborhood Hits	27
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

FGD2_HUMAN
NC score	0.052511 (rank : 153)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

CN155_HUMAN
NC score	0.052477 (rank : 154)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	385	Shared Neighborhood Hits	27
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

GAB1_MOUSE
NC score	0.051984 (rank : 155)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	233	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

WBP11_HUMAN
NC score	0.051984 (rank : 156)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	354	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

RIN3_HUMAN
NC score	0.051938 (rank : 157)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

TARA_MOUSE
NC score	0.051525 (rank : 158)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	1133	Shared Neighborhood Hits	53
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

C43BP_MOUSE
NC score	0.051510 (rank : 159)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	91	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

NFH_MOUSE
NC score	0.051390 (rank : 160)	θ value	0.0148317 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	2247	Shared Neighborhood Hits	60
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PRG4_MOUSE
NC score	0.051181 (rank : 161)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	624	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

NACAM_MOUSE
NC score	0.051116 (rank : 162)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	1866	Shared Neighborhood Hits	60
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SHD_HUMAN
NC score	0.050766 (rank : 163)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

WBP11_MOUSE
NC score	0.050732 (rank : 164)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	362	Shared Neighborhood Hits	21
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

GRAP2_HUMAN
NC score	0.050679 (rank : 165)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	304	Shared Neighborhood Hits	28
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

WASL_MOUSE
NC score	0.050615 (rank : 166)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

GAB2_HUMAN
NC score	0.050287 (rank : 167)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	188	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

VAV_HUMAN
NC score	0.050231 (rank : 168)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	452	Shared Neighborhood Hits	33
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CHIN_HUMAN
NC score	0.050169 (rank : 169)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	227	Shared Neighborhood Hits	28
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SON_HUMAN
NC score	0.050001 (rank : 170)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	1568	Shared Neighborhood Hits	59
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NCOA6_HUMAN
NC score	0.048685 (rank : 171)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	1202	Shared Neighborhood Hits	47
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MAP2_HUMAN
NC score	0.048339 (rank : 172)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	348	Shared Neighborhood Hits	18
SwissProt Accessions	P11137, Q99975, Q99976	Gene names	MAP2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2) (MAP-2).

FA47A_HUMAN
NC score	0.046971 (rank : 173)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

CSK_MOUSE
NC score	0.045613 (rank : 174)	θ value	0.0193708 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

SELPL_MOUSE
NC score	0.045056 (rank : 175)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	588	Shared Neighborhood Hits	33
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MLL3_HUMAN
NC score	0.044927 (rank : 176)	θ value	0.813845 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	1644	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MILK1_MOUSE
NC score	0.044888 (rank : 177)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	788	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CENG1_MOUSE
NC score	0.044848 (rank : 178)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	531	Shared Neighborhood Hits	30
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

MATK_HUMAN
NC score	0.044595 (rank : 179)	θ value	0.0252991 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	954	Shared Neighborhood Hits	34
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

CSK_HUMAN
NC score	0.044291 (rank : 180)	θ value	0.0431538 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

MATK_MOUSE
NC score	0.043738 (rank : 181)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	952	Shared Neighborhood Hits	33
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

BRD4_MOUSE
NC score	0.043519 (rank : 182)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CENG3_MOUSE
NC score	0.043011 (rank : 183)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	467	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG1_HUMAN
NC score	0.042201 (rank : 184)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	544	Shared Neighborhood Hits	27
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

LRC56_HUMAN
NC score	0.041760 (rank : 185)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	165	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

CENG3_HUMAN
NC score	0.038830 (rank : 186)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

FGR_HUMAN
NC score	0.038449 (rank : 187)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	1067	Shared Neighborhood Hits	38
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GR65_HUMAN
NC score	0.038139 (rank : 188)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

MBD5_HUMAN
NC score	0.037529 (rank : 189)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	176	Shared Neighborhood Hits	8
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

STAT2_MOUSE
NC score	0.037393 (rank : 190)	θ value	0.163984 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

RGS3_MOUSE
NC score	0.036704 (rank : 191)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	1621	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

CENG2_HUMAN
NC score	0.036526 (rank : 192)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	471	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

BMX_HUMAN
NC score	0.036500 (rank : 193)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	942	Shared Neighborhood Hits	53
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ETV3_HUMAN
NC score	0.034264 (rank : 194)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	312	Shared Neighborhood Hits	17
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

PRR3_HUMAN
NC score	0.034094 (rank : 195)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	P79522, Q5RJB5	Gene names	PRR3, CAT56
Domain Architecture	No domain graphic available
Description	Proline-rich protein 3 (MHC class I region proline-rich protein CAT56).

SF04_MOUSE
NC score	0.033828 (rank : 196)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CH02, Q8R094	Gene names	Sf4
Domain Architecture	No domain graphic available
Description	Splicing factor 4.

BLK_HUMAN
NC score	0.032481 (rank : 197)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	994	Shared Neighborhood Hits	33
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

RP1L1_HUMAN
NC score	0.032474 (rank : 198)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	1072	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

TPX2_HUMAN
NC score	0.032294 (rank : 199)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	150	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULW0, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1	Gene names	TPX2, C20orf1, C20orf2, DIL2, HCA519
Domain Architecture	No domain graphic available
Description	Targeting protein for Xklp2 (Restricted expression proliferation- associated protein 100) (p100) (Differentially expressed in cancerous and noncancerous lung cells 2) (DIL-2) (Protein FLS353) (Hepatocellular carcinoma-associated antigen 519).

AGT2_HUMAN
NC score	0.031451 (rank : 200)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYV1, Q53FB4, Q53FY7, Q53G03, Q5W7Q1	Gene names	AGXT2, AGT2
Domain Architecture
Description	Alanine--glyoxylate aminotransferase 2, mitochondrial precursor (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (AGT 2) (Beta-alanine-pyruvate aminotransferase) (Beta- ALAAT II) (D-AIBAT).

ALMS1_MOUSE
NC score	0.030837 (rank : 201)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	181	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

CSKI1_HUMAN
NC score	0.030756 (rank : 202)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	997	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CBX2_HUMAN
NC score	0.030262 (rank : 203)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

STAR8_HUMAN
NC score	0.029874 (rank : 204)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	216	Shared Neighborhood Hits	19
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

BLK_MOUSE
NC score	0.028744 (rank : 205)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	992	Shared Neighborhood Hits	33
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

GR65_MOUSE
NC score	0.028600 (rank : 206)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

I12R2_HUMAN
NC score	0.027790 (rank : 207)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

CSKI2_HUMAN
NC score	0.027729 (rank : 208)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	747	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

E41L1_HUMAN
NC score	0.027557 (rank : 209)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	180	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
NC score	0.027363 (rank : 210)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

PRAX_HUMAN
NC score	0.026724 (rank : 211)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	215	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

BTBDC_HUMAN
NC score	0.025692 (rank : 212)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

AAK1_HUMAN
NC score	0.023671 (rank : 213)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	1077	Shared Neighborhood Hits	39
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

SPEG_MOUSE
NC score	0.023639 (rank : 214)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	1959	Shared Neighborhood Hits	57
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

M3K9_HUMAN
NC score	0.023155 (rank : 215)	θ value	0.62314 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	1123	Shared Neighborhood Hits	25
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

PLXB1_HUMAN
NC score	0.020865 (rank : 216)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	360	Shared Neighborhood Hits	14
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

DCC_MOUSE
NC score	0.020650 (rank : 217)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

SPEG_HUMAN
NC score	0.020643 (rank : 218)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	1762	Shared Neighborhood Hits	51
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

LTBP4_MOUSE
NC score	0.017873 (rank : 219)	θ value	0.62314 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	607	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

GP1BA_HUMAN
NC score	0.017668 (rank : 220)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	407	Shared Neighborhood Hits	14
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

DCC_HUMAN
NC score	0.016660 (rank : 221)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	583	Shared Neighborhood Hits	13
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

HEM1_MOUSE
NC score	0.014905 (rank : 222)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC19, Q64453	Gene names	Alas1
Domain Architecture	No domain graphic available
Description	5-aminolevulinate synthase, nonspecific, mitochondrial precursor (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) (ALAS-H).

TNIK_HUMAN
NC score	0.012704 (rank : 223)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	1570	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

HSF4_MOUSE
NC score	0.012696 (rank : 224)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0L1, Q9R0L2	Gene names	Hsf4
Domain Architecture
Description	Heat shock factor protein 4 (HSF 4) (Heat shock transcription factor 4) (HSTF 4) (mHSF4).

EHMT2_MOUSE
NC score	0.011068 (rank : 225)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	750	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

IC1_MOUSE
NC score	0.008823 (rank : 226)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	164	Shared Neighborhood Hits	7
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

UBP8_HUMAN
NC score	0.008737 (rank : 227)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	751	Shared Neighborhood Hits	9
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

KCC1G_MOUSE
NC score	0.008343 (rank : 228)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	851	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KS6A4_HUMAN
NC score	0.008312 (rank : 229)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	868	Shared Neighborhood Hits	16
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

MPP6_MOUSE
NC score	0.008302 (rank : 230)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	187	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MTR1L_HUMAN
NC score	0.007656 (rank : 231)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	1180	Shared Neighborhood Hits	16
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

ZN628_HUMAN
NC score	0.002250 (rank : 232)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	814	Shared Neighborhood Hits	18
SwissProt Accessions	Q5EBL2, Q86X34	Gene names	ZNF628
Domain Architecture	No domain graphic available
Description	Zinc finger protein 628.

GLI2_HUMAN
NC score	0.002152 (rank : 233)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	971	Shared Neighborhood Hits	17
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

SIP1_MOUSE
NC score	0.000720 (rank : 234)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	870	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

ZN473_MOUSE
NC score	-0.001198 (rank : 235)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	824	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BI67, Q8BI98, Q8BIB7	Gene names	Znf473, Zfp100, Zfp473
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 homolog (Zinc finger protein 100) (Zfp-100).

ZN551_HUMAN
NC score	-0.001749 (rank : 236)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	753	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z340, P17034, Q8N246, Q9BRY1	Gene names	ZNF551, KOX23
Domain Architecture	No domain graphic available
Description	Zinc finger protein 551 (Zinc finger protein KOX23).