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Network neighborhood for query Sequence : FBX8_MOUSE

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FBX8_MOUSE
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FBX8_MOUSE
θ value	2.17438e-179 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
θ value	5.73535e-172 (rank : 2)	NC score	0.999266 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

BIG1_HUMAN
θ value	1.02238e-19 (rank : 3)	NC score	0.775602 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CYH2_MOUSE
θ value	1.74391e-19 (rank : 4)	NC score	0.762848 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
θ value	3.88503e-19 (rank : 5)	NC score	0.761867 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	22
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

IQEC2_HUMAN
θ value	1.13037e-18 (rank : 6)	NC score	0.744402 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	403	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

CYH3_MOUSE
θ value	2.5182e-18 (rank : 7)	NC score	0.751505 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	148	Shared Neighborhood Hits	22
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

IQEC2_MOUSE
θ value	2.5182e-18 (rank : 8)	NC score	0.743007 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	417	Shared Neighborhood Hits	22
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC1_HUMAN
θ value	4.29542e-18 (rank : 9)	NC score	0.781334 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

CYH3_HUMAN
θ value	7.32683e-18 (rank : 10)	NC score	0.755789 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	137	Shared Neighborhood Hits	22
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

IQEC3_MOUSE
θ value	9.56915e-18 (rank : 11)	NC score	0.777222 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CYH1_MOUSE
θ value	1.63225e-17 (rank : 12)	NC score	0.752672 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH4_HUMAN
θ value	2.13179e-17 (rank : 13)	NC score	0.756327 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

IQEC1_MOUSE
θ value	2.13179e-17 (rank : 14)	NC score	0.781509 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC3_HUMAN
θ value	3.63628e-17 (rank : 15)	NC score	0.785143 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	125	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CYH1_HUMAN
θ value	1.38178e-16 (rank : 16)	NC score	0.748326 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH4_MOUSE
θ value	2.35696e-16 (rank : 17)	NC score	0.753708 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

BIG2_HUMAN
θ value	1.16975e-15 (rank : 18)	NC score	0.758627 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

GBF1_HUMAN
θ value	5.26297e-08 (rank : 19)	NC score	0.715186 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PSD4_HUMAN
θ value	9.92553e-07 (rank : 20)	NC score	0.614194 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD3_HUMAN
θ value	1.09739e-05 (rank : 21)	NC score	0.644210 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
θ value	1.09739e-05 (rank : 22)	NC score	0.615475 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

FBXW7_HUMAN
θ value	0.00298849 (rank : 23)	NC score	0.061658 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	433	Shared Neighborhood Hits	23
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

FBXW7_MOUSE
θ value	0.00298849 (rank : 24)	NC score	0.062078 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	365	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

FBX11_HUMAN
θ value	0.00509761 (rank : 25)	NC score	0.147552 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q86XK2, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2	Gene names	FBXO11, FBX11, VIT1
Domain Architecture
Description	F-box only protein 11 (Vitiligo-associated protein VIT-1).

FBXL5_MOUSE
θ value	0.0252991 (rank : 26)	NC score	0.133882 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C2S5, Q3TWC9, Q80XI5, Q8BGF5, Q8BNL3, Q8C3Q8	Gene names	Fbxl5
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5).

FBXL5_HUMAN
θ value	0.0431538 (rank : 27)	NC score	0.128956 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKA1, Q8NHP3, Q9NXN2, Q9P0I0, Q9P0X5, Q9UJT7, Q9UKC8	Gene names	FBXL5, FBL4, FBL5, FLR1
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein).

FBXW8_MOUSE
θ value	0.0431538 (rank : 28)	NC score	0.133666 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

FBXW8_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.120373 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	192	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

FBX15_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.091123 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NCQ5	Gene names	FBXO15, FBX15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

FBW1A_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.041859 (rank : 76)
Query Neighborhood Hits	45	Target Neighborhood Hits	329	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

FBX15_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.072065 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QZN0	Gene names	Fbxo15, Fbx15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

FBX3_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.067001 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DC63, Q3TKB0	Gene names	Fbxo3, Fba, Fbx3
Domain Architecture
Description	F-box only protein 3.

FBXL2_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.056500 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKC9, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9	Gene names	FBXL2, FBL2, FBL3
Domain Architecture
Description	F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3).

FBXW2_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.045334 (rank : 74)
Query Neighborhood Hits	45	Target Neighborhood Hits	260	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

SKP2_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.058928 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q13309, Q8TDZ0, Q8TDZ1, Q9BV69	Gene names	SKP2, FBXL1
Domain Architecture
Description	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1).

FBX3_HUMAN
θ value	3.0926 (rank : 37)	NC score	0.064028 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UK99, Q9NUX2	Gene names	FBXO3, FBX3
Domain Architecture
Description	F-box only protein 3.

FBXL2_MOUSE
θ value	3.0926 (rank : 38)	NC score	0.052139 (rank : 66)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH16, Q8BXM4	Gene names	Fbxl2, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2).

FBX31_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.067351 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

FBW1B_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.036824 (rank : 78)
Query Neighborhood Hits	45	Target Neighborhood Hits	327	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

FXL20_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.048703 (rank : 73)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.048738 (rank : 72)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

ZN33A_HUMAN
θ value	6.88961 (rank : 43)	NC score	-0.003152 (rank : 79)
Query Neighborhood Hits	45	Target Neighborhood Hits	780	Shared Neighborhood Hits	2
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).

FBX36_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.038011 (rank : 77)
Query Neighborhood Hits	45	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEA4, Q8WWD4	Gene names	FBXO36, FBX36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

FBX4_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.043906 (rank : 75)
Query Neighborhood Hits	45	Target Neighborhood Hits	33	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKT5, Q68CU8, Q86VT8, Q9UK98	Gene names	FBXO4, FBX4
Domain Architecture
Description	F-box only protein 4.

3BP2_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.099518 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.103207 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

ANLN_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.105337 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	222	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANLN_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.086357 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

CENB2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.060717 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	10
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.055144 (rank : 64)
Query Neighborhood Hits	45	Target Neighborhood Hits	395	Shared Neighborhood Hits	8
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CNKR1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.169591 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CNKR2_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.089424 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.089503 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DAPP1_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.101522 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.106805 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

FBX16_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.052643 (rank : 65)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX29, Q3T1B4	Gene names	FBXO16, FBX16
Domain Architecture
Description	F-box only protein 16.

FBX16_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.050090 (rank : 71)
Query Neighborhood Hits	45	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZM9, Q3TP74, Q8C5V6	Gene names	Fbxo16, Fbx16
Domain Architecture
Description	F-box only protein 16.

GNRP_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.051286 (rank : 69)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	9
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHA1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.121661 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	127	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.121265 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.094110 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.106692 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.102088 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	283	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.111569 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.084791 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.118808 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	556	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.113498 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	591	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHB2_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.051907 (rank : 67)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	8
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.051004 (rank : 70)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PLEK2_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.091676 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.093168 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.118186 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.121572 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA1_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.072444 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	258	Shared Neighborhood Hits	8
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG25_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.066353 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	550	Shared Neighborhood Hits	8
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.069956 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	492	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SWP70_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.060337 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	973	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.051657 (rank : 68)
Query Neighborhood Hits	45	Target Neighborhood Hits	1097	Shared Neighborhood Hits	8
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

Hits sorted by NC score

FBX8_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.17438e-179 (rank : 1)
Query Neighborhood Hits	45	Target Neighborhood Hits	45	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QZN3	Gene names	Fbxo8, Fbx8
Domain Architecture
Description	F-box only protein 8.

FBX8_HUMAN
NC score	0.999266 (rank : 2)	θ value	5.73535e-172 (rank : 2)
Query Neighborhood Hits	45	Target Neighborhood Hits	44	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NRD0, Q6UWN4, Q9NRP5, Q9UKC4	Gene names	FBXO8, FBS, FBX8
Domain Architecture
Description	F-box only protein 8 (F-box/SEC7 protein FBS).

IQEC3_HUMAN
NC score	0.785143 (rank : 3)	θ value	3.63628e-17 (rank : 15)
Query Neighborhood Hits	45	Target Neighborhood Hits	125	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IQEC1_MOUSE
NC score	0.781509 (rank : 4)	θ value	2.13179e-17 (rank : 14)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	22
SwissProt Accessions	Q8R0S2, Q3TZC3, Q5DU15	Gene names	Iqsec1, Kiaa0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1.

IQEC1_HUMAN
NC score	0.781334 (rank : 5)	θ value	4.29542e-18 (rank : 9)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IQEC3_MOUSE
NC score	0.777222 (rank : 6)	θ value	9.56915e-18 (rank : 11)
Query Neighborhood Hits	45	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

BIG1_HUMAN
NC score	0.775602 (rank : 7)	θ value	1.02238e-19 (rank : 3)
Query Neighborhood Hits	45	Target Neighborhood Hits	76	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CYH2_MOUSE
NC score	0.762848 (rank : 8)	θ value	1.74391e-19 (rank : 4)
Query Neighborhood Hits	45	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.761867 (rank : 9)	θ value	3.88503e-19 (rank : 5)
Query Neighborhood Hits	45	Target Neighborhood Hits	175	Shared Neighborhood Hits	22
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

BIG2_HUMAN
NC score	0.758627 (rank : 10)	θ value	1.16975e-15 (rank : 18)
Query Neighborhood Hits	45	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CYH4_HUMAN
NC score	0.756327 (rank : 11)	θ value	2.13179e-17 (rank : 13)
Query Neighborhood Hits	45	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH3_HUMAN
NC score	0.755789 (rank : 12)	θ value	7.32683e-18 (rank : 10)
Query Neighborhood Hits	45	Target Neighborhood Hits	137	Shared Neighborhood Hits	22
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH4_MOUSE
NC score	0.753708 (rank : 13)	θ value	2.35696e-16 (rank : 17)
Query Neighborhood Hits	45	Target Neighborhood Hits	134	Shared Neighborhood Hits	22
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_MOUSE
NC score	0.752672 (rank : 14)	θ value	1.63225e-17 (rank : 12)
Query Neighborhood Hits	45	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

CYH3_MOUSE
NC score	0.751505 (rank : 15)	θ value	2.5182e-18 (rank : 7)
Query Neighborhood Hits	45	Target Neighborhood Hits	148	Shared Neighborhood Hits	22
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_HUMAN
NC score	0.748326 (rank : 16)	θ value	1.38178e-16 (rank : 16)
Query Neighborhood Hits	45	Target Neighborhood Hits	184	Shared Neighborhood Hits	22
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

IQEC2_HUMAN
NC score	0.744402 (rank : 17)	θ value	1.13037e-18 (rank : 6)
Query Neighborhood Hits	45	Target Neighborhood Hits	403	Shared Neighborhood Hits	22
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
NC score	0.743007 (rank : 18)	θ value	2.5182e-18 (rank : 8)
Query Neighborhood Hits	45	Target Neighborhood Hits	417	Shared Neighborhood Hits	22
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

GBF1_HUMAN
NC score	0.715186 (rank : 19)	θ value	5.26297e-08 (rank : 19)
Query Neighborhood Hits	45	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PSD3_HUMAN
NC score	0.644210 (rank : 20)	θ value	1.09739e-05 (rank : 21)
Query Neighborhood Hits	45	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
NC score	0.615475 (rank : 21)	θ value	1.09739e-05 (rank : 22)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PSD4_HUMAN
NC score	0.614194 (rank : 22)	θ value	9.92553e-07 (rank : 20)
Query Neighborhood Hits	45	Target Neighborhood Hits	178	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CNKR1_HUMAN
NC score	0.169591 (rank : 23)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	45	Target Neighborhood Hits	154	Shared Neighborhood Hits	11
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

FBX11_HUMAN
NC score	0.147552 (rank : 24)	θ value	0.00509761 (rank : 25)
Query Neighborhood Hits	45	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q86XK2, Q8IXG3, Q96E90, Q9H6V8, Q9H9L1, Q9NR14, Q9UFK1, Q9UHI1, Q9UKC2	Gene names	FBXO11, FBX11, VIT1
Domain Architecture
Description	F-box only protein 11 (Vitiligo-associated protein VIT-1).

FBXL5_MOUSE
NC score	0.133882 (rank : 25)	θ value	0.0252991 (rank : 26)
Query Neighborhood Hits	45	Target Neighborhood Hits	103	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C2S5, Q3TWC9, Q80XI5, Q8BGF5, Q8BNL3, Q8C3Q8	Gene names	Fbxl5
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5).

FBXW8_MOUSE
NC score	0.133666 (rank : 26)	θ value	0.0431538 (rank : 28)
Query Neighborhood Hits	45	Target Neighborhood Hits	162	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BIA4, Q8BI62, Q8BI75, Q8BI76, Q8CID8, Q921Z1	Gene names	Fbxw8
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8).

FBXL5_HUMAN
NC score	0.128956 (rank : 27)	θ value	0.0431538 (rank : 27)
Query Neighborhood Hits	45	Target Neighborhood Hits	111	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UKA1, Q8NHP3, Q9NXN2, Q9P0I0, Q9P0X5, Q9UJT7, Q9UKC8	Gene names	FBXL5, FBL4, FBL5, FLR1
Domain Architecture
Description	F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein).

PKHA1_HUMAN
NC score	0.121661 (rank : 28)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	45	Target Neighborhood Hits	127	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK_MOUSE
NC score	0.121572 (rank : 29)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	45	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PKHA1_MOUSE
NC score	0.121265 (rank : 30)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	45	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

FBXW8_HUMAN
NC score	0.120373 (rank : 31)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	45	Target Neighborhood Hits	192	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N3Y1, Q9UK95	Gene names	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6
Domain Architecture
Description	F-box/WD repeat protein 8 (F-box and WD-40 domain protein 8) (F-box only protein 29).

PKHA6_HUMAN
NC score	0.118808 (rank : 32)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	45	Target Neighborhood Hits	556	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK_HUMAN
NC score	0.118186 (rank : 33)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	45	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA6_MOUSE
NC score	0.113498 (rank : 34)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	45	Target Neighborhood Hits	591	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA4_MOUSE
NC score	0.111569 (rank : 35)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	45	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_MOUSE
NC score	0.106805 (rank : 36)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	45	Target Neighborhood Hits	225	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA2_MOUSE
NC score	0.106692 (rank : 37)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	45	Target Neighborhood Hits	116	Shared Neighborhood Hits	9
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

ANLN_HUMAN
NC score	0.105337 (rank : 38)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	45	Target Neighborhood Hits	222	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

3BP2_MOUSE
NC score	0.103207 (rank : 39)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	45	Target Neighborhood Hits	142	Shared Neighborhood Hits	8
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA4_HUMAN
NC score	0.102088 (rank : 40)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	45	Target Neighborhood Hits	283	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DAPP1_HUMAN
NC score	0.101522 (rank : 41)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	45	Target Neighborhood Hits	227	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

3BP2_HUMAN
NC score	0.099518 (rank : 42)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	45	Target Neighborhood Hits	296	Shared Neighborhood Hits	8
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA2_HUMAN
NC score	0.094110 (rank : 43)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	45	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PLEK2_MOUSE
NC score	0.093168 (rank : 44)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	45	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.091676 (rank : 45)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	45	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

FBX15_HUMAN
NC score	0.091123 (rank : 46)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	45	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NCQ5	Gene names	FBXO15, FBX15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

CNKR2_MOUSE
NC score	0.089503 (rank : 47)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.089424 (rank : 48)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	45	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ANLN_MOUSE
NC score	0.086357 (rank : 49)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	45	Target Neighborhood Hits	297	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

PKHA5_HUMAN
NC score	0.084791 (rank : 50)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	45	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RASA1_HUMAN
NC score	0.072444 (rank : 51)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	45	Target Neighborhood Hits	258	Shared Neighborhood Hits	8
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

FBX15_MOUSE
NC score	0.072065 (rank : 52)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	45	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QZN0	Gene names	Fbxo15, Fbx15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

RHG25_MOUSE
NC score	0.069956 (rank : 53)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	45	Target Neighborhood Hits	492	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

FBX31_HUMAN
NC score	0.067351 (rank : 54)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	45	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	Q5XUX0, Q96D73, Q9UFV4	Gene names	FBXO31, FBX14, FBX31
Domain Architecture	No domain graphic available
Description	F-box only protein 31.

FBX3_MOUSE
NC score	0.067001 (rank : 55)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	45	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DC63, Q3TKB0	Gene names	Fbxo3, Fba, Fbx3
Domain Architecture
Description	F-box only protein 3.

RHG25_HUMAN
NC score	0.066353 (rank : 56)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	45	Target Neighborhood Hits	550	Shared Neighborhood Hits	8
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

FBX3_HUMAN
NC score	0.064028 (rank : 57)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	45	Target Neighborhood Hits	41	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UK99, Q9NUX2	Gene names	FBXO3, FBX3
Domain Architecture
Description	F-box only protein 3.

FBXW7_MOUSE
NC score	0.062078 (rank : 58)	θ value	0.00298849 (rank : 24)
Query Neighborhood Hits	45	Target Neighborhood Hits	365	Shared Neighborhood Hits	23
SwissProt Accessions	Q8VBV4, Q8CCS5, Q8VHP4	Gene names	Fbxw7, Fbw7, Fbwd6, Fbxw6
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10).

FBXW7_HUMAN
NC score	0.061658 (rank : 59)	θ value	0.00298849 (rank : 23)
Query Neighborhood Hits	45	Target Neighborhood Hits	433	Shared Neighborhood Hits	23
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

CENB2_HUMAN
NC score	0.060717 (rank : 60)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	45	Target Neighborhood Hits	425	Shared Neighborhood Hits	10
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

SWP70_HUMAN
NC score	0.060337 (rank : 61)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	45	Target Neighborhood Hits	973	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SKP2_HUMAN
NC score	0.058928 (rank : 62)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	45	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q13309, Q8TDZ0, Q8TDZ1, Q9BV69	Gene names	SKP2, FBXL1
Domain Architecture
Description	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1).

FBXL2_HUMAN
NC score	0.056500 (rank : 63)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UKC9, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9	Gene names	FBXL2, FBL2, FBL3
Domain Architecture
Description	F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3).

CENB5_HUMAN
NC score	0.055144 (rank : 64)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	45	Target Neighborhood Hits	395	Shared Neighborhood Hits	8
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

FBX16_HUMAN
NC score	0.052643 (rank : 65)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	45	Target Neighborhood Hits	51	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX29, Q3T1B4	Gene names	FBXO16, FBX16
Domain Architecture
Description	F-box only protein 16.

FBXL2_MOUSE
NC score	0.052139 (rank : 66)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	45	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BH16, Q8BXM4	Gene names	Fbxl2, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2).

PKHB2_HUMAN
NC score	0.051907 (rank : 67)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	45	Target Neighborhood Hits	54	Shared Neighborhood Hits	8
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

SWP70_MOUSE
NC score	0.051657 (rank : 68)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	45	Target Neighborhood Hits	1097	Shared Neighborhood Hits	8
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GNRP_HUMAN
NC score	0.051286 (rank : 69)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	45	Target Neighborhood Hits	239	Shared Neighborhood Hits	9
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHB2_MOUSE
NC score	0.051004 (rank : 70)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	45	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

FBX16_MOUSE
NC score	0.050090 (rank : 71)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	45	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZM9, Q3TP74, Q8C5V6	Gene names	Fbxo16, Fbx16
Domain Architecture
Description	F-box only protein 16.

FXL20_MOUSE
NC score	0.048738 (rank : 72)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	45	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q9CZV8, Q8BZ95	Gene names	Fbxl20, Fbl2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FXL20_HUMAN
NC score	0.048703 (rank : 73)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	45	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q96IG2	Gene names	FBXL20, FBL2
Domain Architecture
Description	F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein 20) (F-box/LRR-repeat protein 2-like).

FBXW2_HUMAN
NC score	0.045334 (rank : 74)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	45	Target Neighborhood Hits	260	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UKT8, Q7Z4V6, Q8WV51, Q9HA09, Q9UKA3	Gene names	FBXW2, FBW2, FWD2
Domain Architecture
Description	F-box/WD repeat protein 2 (F-box and WD-40 domain protein 2) (MD6 protein).

FBX4_HUMAN
NC score	0.043906 (rank : 75)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	45	Target Neighborhood Hits	33	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKT5, Q68CU8, Q86VT8, Q9UK98	Gene names	FBXO4, FBX4
Domain Architecture
Description	F-box only protein 4.

FBW1A_HUMAN
NC score	0.041859 (rank : 76)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	45	Target Neighborhood Hits	329	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y297, Q9Y213	Gene names	BTRC, BTRCP, FBW1A, FBXW1A
Domain Architecture
Description	F-box/WD repeat protein 1A (F-box and WD repeats protein beta-TrCP) (E3RSIkappaB) (pIkappaBalpha-E3 receptor subunit).

FBX36_HUMAN
NC score	0.038011 (rank : 77)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	45	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NEA4, Q8WWD4	Gene names	FBXO36, FBX36
Domain Architecture	No domain graphic available
Description	F-box only protein 36.

FBW1B_HUMAN
NC score	0.036824 (rank : 78)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	45	Target Neighborhood Hits	327	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKB1, Q9P2S8, Q9P2S9, Q9Y4C6	Gene names	FBXW11, BTRCP2, FBW1B, FBXW1B, KIAA0696
Domain Architecture
Description	F-box/WD repeat protein 11 (F-box/WD repeat protein 1B) (F-box and WD repeats protein beta-TrCP2).

ZN33A_HUMAN
NC score	-0.003152 (rank : 79)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	45	Target Neighborhood Hits	780	Shared Neighborhood Hits	2
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).