Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PKHB1_HUMAN

For an explanation of this page, click here

PKHB1_HUMAN
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHB1_MOUSE
θ value	1.80787e-125 (rank : 1)	NC score	0.997301 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_HUMAN
θ value	3.52827e-121 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_HUMAN
θ value	1.85889e-29 (rank : 3)	NC score	0.862958 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	54	Shared Neighborhood Hits	36
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_MOUSE
θ value	2.42779e-29 (rank : 4)	NC score	0.865314 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHA6_HUMAN
θ value	0.00035302 (rank : 5)	NC score	0.276647 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	556	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	0.000602161 (rank : 6)	NC score	0.271084 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	591	Shared Neighborhood Hits	46
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

AKT1_HUMAN
θ value	0.0563607 (rank : 7)	NC score	0.038341 (rank : 61)
Query Neighborhood Hits	46	Target Neighborhood Hits	885	Shared Neighborhood Hits	29
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	0.0563607 (rank : 8)	NC score	0.038373 (rank : 60)
Query Neighborhood Hits	46	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

OSBP1_HUMAN
θ value	0.0736092 (rank : 9)	NC score	0.121308 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	180	Shared Neighborhood Hits	36
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PKHA5_HUMAN
θ value	0.0736092 (rank : 10)	NC score	0.219026 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	455	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA4_HUMAN
θ value	0.0961366 (rank : 11)	NC score	0.235535 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	283	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH3_MOUSE
θ value	0.125558 (rank : 12)	NC score	0.160977 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

OSBP2_HUMAN
θ value	0.125558 (rank : 13)	NC score	0.115772 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

AKT2_HUMAN
θ value	0.163984 (rank : 14)	NC score	0.037219 (rank : 62)
Query Neighborhood Hits	46	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	0.163984 (rank : 15)	NC score	0.037167 (rank : 63)
Query Neighborhood Hits	46	Target Neighborhood Hits	875	Shared Neighborhood Hits	27
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CYH4_HUMAN
θ value	0.163984 (rank : 16)	NC score	0.154485 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

PKHA4_MOUSE
θ value	0.163984 (rank : 17)	NC score	0.235654 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	202	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CYH4_MOUSE
θ value	0.365318 (rank : 18)	NC score	0.153352 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

OSBP2_MOUSE
θ value	0.365318 (rank : 19)	NC score	0.109183 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

RHG25_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.123732 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	492	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MRIP_MOUSE
θ value	0.62314 (rank : 21)	NC score	0.113314 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	569	Shared Neighborhood Hits	37
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

RHG25_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.114375 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	550	Shared Neighborhood Hits	43
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

GNRP_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.064055 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MRIP_HUMAN
θ value	0.813845 (rank : 24)	NC score	0.111033 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	578	Shared Neighborhood Hits	37
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

CYH1_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.142511 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	184	Shared Neighborhood Hits	45
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	1.06291 (rank : 26)	NC score	0.141758 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	176	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DYN1_HUMAN
θ value	1.06291 (rank : 27)	NC score	0.077582 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	216	Shared Neighborhood Hits	24
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	1.06291 (rank : 28)	NC score	0.078157 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	168	Shared Neighborhood Hits	24
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

TARA_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.066333 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	1626	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DYN2_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.086101 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.086116 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

TARA_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.088258 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	1133	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CEND1_MOUSE
θ value	1.81305 (rank : 33)	NC score	0.047742 (rank : 58)
Query Neighborhood Hits	46	Target Neighborhood Hits	260	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

GNRP_HUMAN
θ value	1.81305 (rank : 34)	NC score	0.063315 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHA2_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.130798 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

CNKR2_HUMAN
θ value	2.36792 (rank : 36)	NC score	0.134156 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	2.36792 (rank : 37)	NC score	0.134272 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA2_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.139042 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CYH3_HUMAN
θ value	3.0926 (rank : 39)	NC score	0.134450 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.130850 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.130844 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PLEK2_HUMAN
θ value	5.27518 (rank : 42)	NC score	0.093411 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

AKT3_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.028780 (rank : 64)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	6.88961 (rank : 44)	NC score	0.028768 (rank : 65)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

CEND1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.050401 (rank : 56)
Query Neighborhood Hits	46	Target Neighborhood Hits	284	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

MYO10_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.046715 (rank : 59)
Query Neighborhood Hits	46	Target Neighborhood Hits	920	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

3BP2_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.061193 (rank : 50)
Query Neighborhood Hits	46	Target Neighborhood Hits	296	Shared Neighborhood Hits	21
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.062077 (rank : 49)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BIG1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.050762 (rank : 54)
Query Neighborhood Hits	46	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

BIG2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.051305 (rank : 53)
Query Neighborhood Hits	46	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

CNKR1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.106797 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	28
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

DAPP1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.080498 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.084004 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DYN3_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.067346 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	158	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GBF1_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.051348 (rank : 52)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

PKHA1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.132484 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.132280 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA3_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.056093 (rank : 51)
Query Neighborhood Hits	46	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.063450 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PLEK2_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.081184 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	96	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.085875 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.078179 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PSD3_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.070711 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.050476 (rank : 55)
Query Neighborhood Hits	46	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSD4_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.050180 (rank : 57)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

Hits sorted by NC score

PKHB1_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.52827e-121 (rank : 2)
Query Neighborhood Hits	46	Target Neighborhood Hits	46	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
NC score	0.997301 (rank : 2)	θ value	1.80787e-125 (rank : 1)
Query Neighborhood Hits	46	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB2_MOUSE
NC score	0.865314 (rank : 3)	θ value	2.42779e-29 (rank : 4)
Query Neighborhood Hits	46	Target Neighborhood Hits	48	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZC7, Q3UDH6, Q8C4I4, Q8CA27	Gene names	Plekhb2, Evt2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHB2_HUMAN
NC score	0.862958 (rank : 4)	θ value	1.85889e-29 (rank : 3)
Query Neighborhood Hits	46	Target Neighborhood Hits	54	Shared Neighborhood Hits	36
SwissProt Accessions	Q96CS7, Q86W37, Q9BV75, Q9NWK1	Gene names	PLEKHB2, EVT2
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 2 (Evectin-2).

PKHA6_HUMAN
NC score	0.276647 (rank : 5)	θ value	0.00035302 (rank : 5)
Query Neighborhood Hits	46	Target Neighborhood Hits	556	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.271084 (rank : 6)	θ value	0.000602161 (rank : 6)
Query Neighborhood Hits	46	Target Neighborhood Hits	591	Shared Neighborhood Hits	46
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA4_MOUSE
NC score	0.235654 (rank : 7)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	46	Target Neighborhood Hits	202	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.235535 (rank : 8)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	46	Target Neighborhood Hits	283	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
NC score	0.219026 (rank : 9)	θ value	0.0736092 (rank : 10)
Query Neighborhood Hits	46	Target Neighborhood Hits	455	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH3_MOUSE
NC score	0.160977 (rank : 10)	θ value	0.125558 (rank : 12)
Query Neighborhood Hits	46	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_HUMAN
NC score	0.154485 (rank : 11)	θ value	0.163984 (rank : 16)
Query Neighborhood Hits	46	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH4_MOUSE
NC score	0.153352 (rank : 12)	θ value	0.365318 (rank : 18)
Query Neighborhood Hits	46	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH1_HUMAN
NC score	0.142511 (rank : 13)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	46	Target Neighborhood Hits	184	Shared Neighborhood Hits	45
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.141758 (rank : 14)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	46	Target Neighborhood Hits	176	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PKHA2_MOUSE
NC score	0.139042 (rank : 15)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	46	Target Neighborhood Hits	116	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CYH3_HUMAN
NC score	0.134450 (rank : 16)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	46	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CNKR2_MOUSE
NC score	0.134272 (rank : 17)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	46	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.134156 (rank : 18)	θ value	2.36792 (rank : 36)
Query Neighborhood Hits	46	Target Neighborhood Hits	197	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA1_HUMAN
NC score	0.132484 (rank : 19)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	46	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.132280 (rank : 20)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	46	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CYH2_HUMAN
NC score	0.130850 (rank : 21)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	46	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.130844 (rank : 22)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	46	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

PKHA2_HUMAN
NC score	0.130798 (rank : 23)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	46	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RHG25_MOUSE
NC score	0.123732 (rank : 24)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	46	Target Neighborhood Hits	492	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OSBP1_HUMAN
NC score	0.121308 (rank : 25)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	46	Target Neighborhood Hits	180	Shared Neighborhood Hits	36
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_HUMAN
NC score	0.115772 (rank : 26)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

RHG25_HUMAN
NC score	0.114375 (rank : 27)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	46	Target Neighborhood Hits	550	Shared Neighborhood Hits	43
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MRIP_MOUSE
NC score	0.113314 (rank : 28)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	46	Target Neighborhood Hits	569	Shared Neighborhood Hits	37
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MRIP_HUMAN
NC score	0.111033 (rank : 29)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	46	Target Neighborhood Hits	578	Shared Neighborhood Hits	37
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

OSBP2_MOUSE
NC score	0.109183 (rank : 30)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	46	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

CNKR1_HUMAN
NC score	0.106797 (rank : 31)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	46	Target Neighborhood Hits	154	Shared Neighborhood Hits	28
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PLEK2_HUMAN
NC score	0.093411 (rank : 32)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	46	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

TARA_MOUSE
NC score	0.088258 (rank : 33)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	46	Target Neighborhood Hits	1133	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DYN2_MOUSE
NC score	0.086116 (rank : 34)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	46	Target Neighborhood Hits	104	Shared Neighborhood Hits	28
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN2_HUMAN
NC score	0.086101 (rank : 35)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	46	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

PLEK_HUMAN
NC score	0.085875 (rank : 36)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	46	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

DAPP1_MOUSE
NC score	0.084004 (rank : 37)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	46	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK2_MOUSE
NC score	0.081184 (rank : 38)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	46	Target Neighborhood Hits	96	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

DAPP1_HUMAN
NC score	0.080498 (rank : 39)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	46	Target Neighborhood Hits	227	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK_MOUSE
NC score	0.078179 (rank : 40)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	46	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

DYN1_MOUSE
NC score	0.078157 (rank : 41)	θ value	1.06291 (rank : 28)
Query Neighborhood Hits	46	Target Neighborhood Hits	168	Shared Neighborhood Hits	24
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
NC score	0.077582 (rank : 42)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	46	Target Neighborhood Hits	216	Shared Neighborhood Hits	24
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

PSD3_HUMAN
NC score	0.070711 (rank : 43)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	46	Target Neighborhood Hits	75	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

DYN3_HUMAN
NC score	0.067346 (rank : 44)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	46	Target Neighborhood Hits	158	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

TARA_HUMAN
NC score	0.066333 (rank : 45)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	46	Target Neighborhood Hits	1626	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GNRP_MOUSE
NC score	0.064055 (rank : 46)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	46	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

PKHA3_MOUSE
NC score	0.063450 (rank : 47)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	46	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

GNRP_HUMAN
NC score	0.063315 (rank : 48)	θ value	1.81305 (rank : 34)
Query Neighborhood Hits	46	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

3BP2_MOUSE
NC score	0.062077 (rank : 49)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_HUMAN
NC score	0.061193 (rank : 50)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	46	Target Neighborhood Hits	296	Shared Neighborhood Hits	21
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PKHA3_HUMAN
NC score	0.056093 (rank : 51)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	46	Target Neighborhood Hits	66	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

GBF1_HUMAN
NC score	0.051348 (rank : 52)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	46	Target Neighborhood Hits	142	Shared Neighborhood Hits	9
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

BIG2_HUMAN
NC score	0.051305 (rank : 53)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	46	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D5, Q5TFT9, Q9NTS1	Gene names	ARFGEF2, ARFGEP2, BIG2
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2).

BIG1_HUMAN
NC score	0.050762 (rank : 54)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	46	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

PSD4_HUMAN
NC score	0.050476 (rank : 55)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	46	Target Neighborhood Hits	178	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CEND1_HUMAN
NC score	0.050401 (rank : 56)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	46	Target Neighborhood Hits	284	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

PSD4_MOUSE
NC score	0.050180 (rank : 57)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	46	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

CEND1_MOUSE
NC score	0.047742 (rank : 58)	θ value	1.81305 (rank : 33)
Query Neighborhood Hits	46	Target Neighborhood Hits	260	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

MYO10_HUMAN
NC score	0.046715 (rank : 59)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	46	Target Neighborhood Hits	920	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

AKT1_MOUSE
NC score	0.038373 (rank : 60)	θ value	0.0563607 (rank : 8)
Query Neighborhood Hits	46	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.038341 (rank : 61)	θ value	0.0563607 (rank : 7)
Query Neighborhood Hits	46	Target Neighborhood Hits	885	Shared Neighborhood Hits	29
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT2_HUMAN
NC score	0.037219 (rank : 62)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	46	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
NC score	0.037167 (rank : 63)	θ value	0.163984 (rank : 15)
Query Neighborhood Hits	46	Target Neighborhood Hits	875	Shared Neighborhood Hits	27
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
NC score	0.028780 (rank : 64)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.028768 (rank : 65)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	46	Target Neighborhood Hits	872	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).