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Network neighborhood for query Sequence : FGD6_MOUSE

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FGD6_MOUSE
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD6_HUMAN
θ value	0 (rank : 1)	NC score	0.984160 (rank : 2)
Query Neighborhood Hits	282	Target Neighborhood Hits	237	Shared Neighborhood Hits	162
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	282	Target Neighborhood Hits	282	Shared Neighborhood Hits	282
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
θ value	4.29305e-135 (rank : 3)	NC score	0.902402 (rank : 5)
Query Neighborhood Hits	282	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	3.4095e-124 (rank : 4)	NC score	0.896220 (rank : 8)
Query Neighborhood Hits	282	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD4_HUMAN
θ value	3.81361e-83 (rank : 5)	NC score	0.900326 (rank : 6)
Query Neighborhood Hits	282	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	8.49582e-83 (rank : 6)	NC score	0.899390 (rank : 7)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_MOUSE
θ value	1.5519e-76 (rank : 7)	NC score	0.886826 (rank : 10)
Query Neighborhood Hits	282	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	7.70199e-76 (rank : 8)	NC score	0.888108 (rank : 9)
Query Neighborhood Hits	282	Target Neighborhood Hits	367	Shared Neighborhood Hits	131
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	3.95564e-72 (rank : 9)	NC score	0.905543 (rank : 4)
Query Neighborhood Hits	282	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	1.96316e-71 (rank : 10)	NC score	0.906583 (rank : 3)
Query Neighborhood Hits	282	Target Neighborhood Hits	163	Shared Neighborhood Hits	118
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	2.57589e-55 (rank : 11)	NC score	0.868323 (rank : 11)
Query Neighborhood Hits	282	Target Neighborhood Hits	249	Shared Neighborhood Hits	108
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	2.84797e-54 (rank : 12)	NC score	0.861954 (rank : 12)
Query Neighborhood Hits	282	Target Neighborhood Hits	257	Shared Neighborhood Hits	118
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP2_MOUSE
θ value	1.79215e-40 (rank : 13)	NC score	0.558066 (rank : 24)
Query Neighborhood Hits	282	Target Neighborhood Hits	209	Shared Neighborhood Hits	103
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	3.05695e-40 (rank : 14)	NC score	0.546555 (rank : 30)
Query Neighborhood Hits	282	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	9.20422e-37 (rank : 15)	NC score	0.521989 (rank : 38)
Query Neighborhood Hits	282	Target Neighborhood Hits	241	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_HUMAN
θ value	7.80994e-28 (rank : 16)	NC score	0.718300 (rank : 13)
Query Neighborhood Hits	282	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	5.06226e-27 (rank : 17)	NC score	0.715782 (rank : 16)
Query Neighborhood Hits	282	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	8.08199e-25 (rank : 18)	NC score	0.717929 (rank : 14)
Query Neighborhood Hits	282	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.37858e-24 (rank : 19)	NC score	0.717377 (rank : 15)
Query Neighborhood Hits	282	Target Neighborhood Hits	77	Shared Neighborhood Hits	63
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ECT2_MOUSE
θ value	2.97466e-19 (rank : 20)	NC score	0.652386 (rank : 17)
Query Neighborhood Hits	282	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ITSN1_HUMAN
θ value	3.88503e-19 (rank : 21)	NC score	0.358482 (rank : 84)
Query Neighborhood Hits	282	Target Neighborhood Hits	1757	Shared Neighborhood Hits	124
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ECT2_HUMAN
θ value	8.65492e-19 (rank : 22)	NC score	0.639011 (rank : 18)
Query Neighborhood Hits	282	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ITSN1_MOUSE
θ value	1.92812e-18 (rank : 23)	NC score	0.358778 (rank : 83)
Query Neighborhood Hits	282	Target Neighborhood Hits	1669	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PREX1_HUMAN
θ value	9.56915e-18 (rank : 24)	NC score	0.635089 (rank : 19)
Query Neighborhood Hits	282	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZFY16_MOUSE
θ value	2.7842e-17 (rank : 25)	NC score	0.544016 (rank : 32)
Query Neighborhood Hits	282	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

PKHG1_HUMAN
θ value	6.20254e-17 (rank : 26)	NC score	0.607021 (rank : 20)
Query Neighborhood Hits	282	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_MOUSE
θ value	1.80466e-16 (rank : 27)	NC score	0.572513 (rank : 23)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITSN2_HUMAN
θ value	2.35696e-16 (rank : 28)	NC score	0.384182 (rank : 67)
Query Neighborhood Hits	282	Target Neighborhood Hits	1173	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHGA_HUMAN
θ value	3.07829e-16 (rank : 29)	NC score	0.574406 (rank : 21)
Query Neighborhood Hits	282	Target Neighborhood Hits	187	Shared Neighborhood Hits	69
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITSN2_MOUSE
θ value	4.02038e-16 (rank : 30)	NC score	0.368921 (rank : 74)
Query Neighborhood Hits	282	Target Neighborhood Hits	1371	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

BCR_HUMAN
θ value	5.25075e-16 (rank : 31)	NC score	0.410662 (rank : 57)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ZFY16_HUMAN
θ value	5.25075e-16 (rank : 32)	NC score	0.533390 (rank : 37)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFYV9_HUMAN
θ value	8.95645e-16 (rank : 33)	NC score	0.553032 (rank : 26)
Query Neighborhood Hits	282	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

GNRP_MOUSE
θ value	1.42992e-13 (rank : 34)	NC score	0.463039 (rank : 46)
Query Neighborhood Hits	282	Target Neighborhood Hits	191	Shared Neighborhood Hits	81
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

TRIO_HUMAN
θ value	7.09661e-13 (rank : 35)	NC score	0.190615 (rank : 116)
Query Neighborhood Hits	282	Target Neighborhood Hits	1580	Shared Neighborhood Hits	113
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
θ value	1.2105e-12 (rank : 36)	NC score	0.197610 (rank : 113)
Query Neighborhood Hits	282	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

GNRP_HUMAN
θ value	1.2105e-12 (rank : 37)	NC score	0.434903 (rank : 53)
Query Neighborhood Hits	282	Target Neighborhood Hits	239	Shared Neighborhood Hits	81
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG5_HUMAN
θ value	2.28291e-11 (rank : 38)	NC score	0.572539 (rank : 22)
Query Neighborhood Hits	282	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG4_HUMAN
θ value	5.08577e-11 (rank : 39)	NC score	0.535100 (rank : 36)
Query Neighborhood Hits	282	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NGEF_MOUSE
θ value	5.08577e-11 (rank : 40)	NC score	0.541732 (rank : 34)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ZFY28_HUMAN
θ value	5.08577e-11 (rank : 41)	NC score	0.557471 (rank : 25)
Query Neighborhood Hits	282	Target Neighborhood Hits	152	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

NGEF_HUMAN
θ value	8.67504e-11 (rank : 42)	NC score	0.550249 (rank : 28)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ABR_HUMAN
θ value	1.133e-10 (rank : 43)	NC score	0.401997 (rank : 64)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RUFY2_MOUSE
θ value	1.9326e-10 (rank : 44)	NC score	0.313670 (rank : 90)
Query Neighborhood Hits	282	Target Neighborhood Hits	820	Shared Neighborhood Hits	76
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY2_HUMAN
θ value	2.52405e-10 (rank : 45)	NC score	0.259723 (rank : 100)
Query Neighborhood Hits	282	Target Neighborhood Hits	1208	Shared Neighborhood Hits	92
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

FYCO1_HUMAN
θ value	3.29651e-10 (rank : 46)	NC score	0.225467 (rank : 103)
Query Neighborhood Hits	282	Target Neighborhood Hits	1149	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

VAV3_HUMAN
θ value	4.30538e-10 (rank : 47)	NC score	0.365832 (rank : 78)
Query Neighborhood Hits	282	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG4_MOUSE
θ value	5.62301e-10 (rank : 48)	NC score	0.544230 (rank : 31)
Query Neighborhood Hits	282	Target Neighborhood Hits	185	Shared Neighborhood Hits	66
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MTMR3_HUMAN
θ value	9.59137e-10 (rank : 49)	NC score	0.307662 (rank : 92)
Query Neighborhood Hits	282	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_MOUSE
θ value	9.59137e-10 (rank : 50)	NC score	0.308756 (rank : 91)
Query Neighborhood Hits	282	Target Neighborhood Hits	765	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

VAV3_MOUSE
θ value	9.59137e-10 (rank : 51)	NC score	0.366865 (rank : 77)
Query Neighborhood Hits	282	Target Neighborhood Hits	404	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

RUFY1_HUMAN
θ value	1.63604e-09 (rank : 52)	NC score	0.304353 (rank : 95)
Query Neighborhood Hits	282	Target Neighborhood Hits	848	Shared Neighborhood Hits	76
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_HUMAN
θ value	2.13673e-09 (rank : 53)	NC score	0.304957 (rank : 94)
Query Neighborhood Hits	282	Target Neighborhood Hits	348	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	2.13673e-09 (rank : 54)	NC score	0.305231 (rank : 93)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

EEA1_HUMAN
θ value	2.79066e-09 (rank : 55)	NC score	0.192502 (rank : 115)
Query Neighborhood Hits	282	Target Neighborhood Hits	1796	Shared Neighborhood Hits	111
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ZFY21_HUMAN
θ value	2.79066e-09 (rank : 56)	NC score	0.543191 (rank : 33)
Query Neighborhood Hits	282	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	2.79066e-09 (rank : 57)	NC score	0.547954 (rank : 29)
Query Neighborhood Hits	282	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

EEA1_MOUSE
θ value	6.21693e-09 (rank : 58)	NC score	0.205898 (rank : 109)
Query Neighborhood Hits	282	Target Neighborhood Hits	1637	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYV1_HUMAN
θ value	1.06045e-08 (rank : 59)	NC score	0.368536 (rank : 75)
Query Neighborhood Hits	282	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ARHGG_HUMAN
θ value	1.38499e-08 (rank : 60)	NC score	0.551310 (rank : 27)
Query Neighborhood Hits	282	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	1.80886e-08 (rank : 61)	NC score	0.537418 (rank : 35)
Query Neighborhood Hits	282	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

HGS_MOUSE
θ value	2.36244e-08 (rank : 62)	NC score	0.415794 (rank : 55)
Query Neighborhood Hits	282	Target Neighborhood Hits	589	Shared Neighborhood Hits	85
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FYV1_MOUSE
θ value	5.26297e-08 (rank : 63)	NC score	0.365286 (rank : 79)
Query Neighborhood Hits	282	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

MCF2L_MOUSE
θ value	5.26297e-08 (rank : 64)	NC score	0.481788 (rank : 43)
Query Neighborhood Hits	282	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHGF_HUMAN
θ value	6.87365e-08 (rank : 65)	NC score	0.515636 (rank : 39)
Query Neighborhood Hits	282	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

HGS_HUMAN
θ value	6.87365e-08 (rank : 66)	NC score	0.413919 (rank : 56)
Query Neighborhood Hits	282	Target Neighborhood Hits	517	Shared Neighborhood Hits	80
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ARHG9_HUMAN
θ value	1.17247e-07 (rank : 67)	NC score	0.514669 (rank : 40)
Query Neighborhood Hits	282	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

HAPIP_HUMAN
θ value	1.17247e-07 (rank : 68)	NC score	0.462854 (rank : 47)
Query Neighborhood Hits	282	Target Neighborhood Hits	350	Shared Neighborhood Hits	89
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PKHA6_MOUSE
θ value	1.17247e-07 (rank : 69)	NC score	0.257175 (rank : 102)
Query Neighborhood Hits	282	Target Neighborhood Hits	591	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_HUMAN
θ value	1.99992e-07 (rank : 70)	NC score	0.257473 (rank : 101)
Query Neighborhood Hits	282	Target Neighborhood Hits	556	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

VAV_MOUSE
θ value	1.99992e-07 (rank : 71)	NC score	0.381836 (rank : 68)
Query Neighborhood Hits	282	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG1_HUMAN
θ value	3.41135e-07 (rank : 72)	NC score	0.456468 (rank : 49)
Query Neighborhood Hits	282	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG9_MOUSE
θ value	4.45536e-07 (rank : 73)	NC score	0.512377 (rank : 41)
Query Neighborhood Hits	282	Target Neighborhood Hits	234	Shared Neighborhood Hits	67
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FYCO1_MOUSE
θ value	4.45536e-07 (rank : 74)	NC score	0.206627 (rank : 107)
Query Neighborhood Hits	282	Target Neighborhood Hits	1059	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

MCF2_HUMAN
θ value	5.81887e-07 (rank : 75)	NC score	0.505993 (rank : 42)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG1_MOUSE
θ value	7.59969e-07 (rank : 76)	NC score	0.438391 (rank : 51)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

TIAM1_HUMAN
θ value	7.59969e-07 (rank : 77)	NC score	0.478518 (rank : 44)
Query Neighborhood Hits	282	Target Neighborhood Hits	225	Shared Neighborhood Hits	82
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV_HUMAN
θ value	7.59969e-07 (rank : 78)	NC score	0.377361 (rank : 72)
Query Neighborhood Hits	282	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ANFY1_MOUSE
θ value	1.29631e-06 (rank : 79)	NC score	0.200299 (rank : 111)
Query Neighborhood Hits	282	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
θ value	1.69304e-06 (rank : 80)	NC score	0.199776 (rank : 112)
Query Neighborhood Hits	282	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ARHG8_HUMAN
θ value	3.77169e-06 (rank : 81)	NC score	0.440802 (rank : 50)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

OBSCN_HUMAN
θ value	4.92598e-06 (rank : 82)	NC score	0.091684 (rank : 141)
Query Neighborhood Hits	282	Target Neighborhood Hits	1931	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

VAV2_MOUSE
θ value	4.92598e-06 (rank : 83)	NC score	0.367626 (rank : 76)
Query Neighborhood Hits	282	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ZFYV1_HUMAN
θ value	6.43352e-06 (rank : 84)	NC score	0.408743 (rank : 58)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	1.43324e-05 (rank : 85)	NC score	0.403721 (rank : 63)
Query Neighborhood Hits	282	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ARHGB_HUMAN
θ value	3.19293e-05 (rank : 86)	NC score	0.438212 (rank : 52)
Query Neighborhood Hits	282	Target Neighborhood Hits	375	Shared Neighborhood Hits	75
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

TIAM1_MOUSE
θ value	3.19293e-05 (rank : 87)	NC score	0.475900 (rank : 45)
Query Neighborhood Hits	282	Target Neighborhood Hits	205	Shared Neighborhood Hits	82
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
θ value	4.1701e-05 (rank : 88)	NC score	0.378368 (rank : 71)
Query Neighborhood Hits	282	Target Neighborhood Hits	347	Shared Neighborhood Hits	73
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG2_MOUSE
θ value	5.44631e-05 (rank : 89)	NC score	0.457359 (rank : 48)
Query Neighborhood Hits	282	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGNEF_MOUSE
θ value	5.44631e-05 (rank : 90)	NC score	0.335837 (rank : 88)
Query Neighborhood Hits	282	Target Neighborhood Hits	641	Shared Neighborhood Hits	81
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGC_HUMAN
θ value	7.1131e-05 (rank : 91)	NC score	0.406340 (rank : 60)
Query Neighborhood Hits	282	Target Neighborhood Hits	351	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RBNS5_HUMAN
θ value	7.1131e-05 (rank : 92)	NC score	0.390169 (rank : 66)
Query Neighborhood Hits	282	Target Neighborhood Hits	242	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	7.1131e-05 (rank : 93)	NC score	0.381254 (rank : 69)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFY19_HUMAN
θ value	7.1131e-05 (rank : 94)	NC score	0.362882 (rank : 80)
Query Neighborhood Hits	282	Target Neighborhood Hits	206	Shared Neighborhood Hits	49
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

VAV2_HUMAN
θ value	9.29e-05 (rank : 95)	NC score	0.359234 (rank : 82)
Query Neighborhood Hits	282	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

WDFY1_HUMAN
θ value	0.000158464 (rank : 96)	NC score	0.298453 (rank : 97)
Query Neighborhood Hits	282	Target Neighborhood Hits	305	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

PKHG4_HUMAN
θ value	0.00020696 (rank : 97)	NC score	0.428271 (rank : 54)
Query Neighborhood Hits	282	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ALS2_MOUSE
θ value	0.000270298 (rank : 98)	NC score	0.157684 (rank : 119)
Query Neighborhood Hits	282	Target Neighborhood Hits	111	Shared Neighborhood Hits	25
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHGC_MOUSE
θ value	0.000602161 (rank : 99)	NC score	0.401483 (rank : 65)
Query Neighborhood Hits	282	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EXOC8_HUMAN
θ value	0.000602161 (rank : 100)	NC score	0.078421 (rank : 158)
Query Neighborhood Hits	282	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

MTMRD_HUMAN
θ value	0.000602161 (rank : 101)	NC score	0.092019 (rank : 139)
Query Neighborhood Hits	282	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

LBC_HUMAN
θ value	0.000786445 (rank : 102)	NC score	0.406785 (rank : 59)
Query Neighborhood Hits	282	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

PKHA5_HUMAN
θ value	0.00102713 (rank : 103)	NC score	0.193944 (rank : 114)
Query Neighborhood Hits	282	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRG4_HUMAN
θ value	0.00102713 (rank : 104)	NC score	0.054080 (rank : 262)
Query Neighborhood Hits	282	Target Neighborhood Hits	764	Shared Neighborhood Hits	55
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PKHA3_HUMAN
θ value	0.00134147 (rank : 105)	NC score	0.114734 (rank : 127)
Query Neighborhood Hits	282	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

WDFY2_HUMAN
θ value	0.00134147 (rank : 106)	NC score	0.273598 (rank : 99)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.00134147 (rank : 107)	NC score	0.275756 (rank : 98)
Query Neighborhood Hits	282	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ALS2_HUMAN
θ value	0.00228821 (rank : 108)	NC score	0.142519 (rank : 121)
Query Neighborhood Hits	282	Target Neighborhood Hits	121	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

MAP4_MOUSE
θ value	0.00298849 (rank : 109)	NC score	0.048861 (rank : 292)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MTMR5_HUMAN
θ value	0.00298849 (rank : 110)	NC score	0.080143 (rank : 155)
Query Neighborhood Hits	282	Target Neighborhood Hits	141	Shared Neighborhood Hits	30
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PKHA3_MOUSE
θ value	0.00298849 (rank : 111)	NC score	0.115052 (rank : 126)
Query Neighborhood Hits	282	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

AFF1_HUMAN
θ value	0.00390308 (rank : 112)	NC score	0.042007 (rank : 302)
Query Neighborhood Hits	282	Target Neighborhood Hits	506	Shared Neighborhood Hits	37
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

DNMBP_HUMAN
θ value	0.00390308 (rank : 113)	NC score	0.343493 (rank : 87)
Query Neighborhood Hits	282	Target Neighborhood Hits	413	Shared Neighborhood Hits	75
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_MOUSE
θ value	0.00665767 (rank : 114)	NC score	0.298920 (rank : 96)
Query Neighborhood Hits	282	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CNKR2_HUMAN
θ value	0.00665767 (rank : 115)	NC score	0.139761 (rank : 123)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.00665767 (rank : 116)	NC score	0.140224 (rank : 122)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ZFY19_MOUSE
θ value	0.00665767 (rank : 117)	NC score	0.346411 (rank : 86)
Query Neighborhood Hits	282	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

DNMBP_MOUSE
θ value	0.0148317 (rank : 118)	NC score	0.360741 (rank : 81)
Query Neighborhood Hits	282	Target Neighborhood Hits	435	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CNKR1_HUMAN
θ value	0.0193708 (rank : 119)	NC score	0.149435 (rank : 120)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH4_MOUSE
θ value	0.0252991 (rank : 120)	NC score	0.100195 (rank : 132)
Query Neighborhood Hits	282	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

MARK4_MOUSE
θ value	0.0330416 (rank : 121)	NC score	0.005099 (rank : 406)
Query Neighborhood Hits	282	Target Neighborhood Hits	898	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

PKHA4_MOUSE
θ value	0.0330416 (rank : 122)	NC score	0.180308 (rank : 117)
Query Neighborhood Hits	282	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

TACC2_HUMAN
θ value	0.0330416 (rank : 123)	NC score	0.052311 (rank : 272)
Query Neighborhood Hits	282	Target Neighborhood Hits	856	Shared Neighborhood Hits	55
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

CYH4_HUMAN
θ value	0.0431538 (rank : 124)	NC score	0.094194 (rank : 137)
Query Neighborhood Hits	282	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

NACAM_MOUSE
θ value	0.0431538 (rank : 125)	NC score	0.049670 (rank : 290)
Query Neighborhood Hits	282	Target Neighborhood Hits	1866	Shared Neighborhood Hits	87
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PKHA4_HUMAN
θ value	0.0431538 (rank : 126)	NC score	0.176357 (rank : 118)
Query Neighborhood Hits	282	Target Neighborhood Hits	283	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SWP70_MOUSE
θ value	0.0431538 (rank : 127)	NC score	0.118371 (rank : 125)
Query Neighborhood Hits	282	Target Neighborhood Hits	1097	Shared Neighborhood Hits	100
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH3_MOUSE
θ value	0.0563607 (rank : 128)	NC score	0.106441 (rank : 128)
Query Neighborhood Hits	282	Target Neighborhood Hits	148	Shared Neighborhood Hits	58
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

WDR67_MOUSE
θ value	0.0563607 (rank : 129)	NC score	0.039106 (rank : 309)
Query Neighborhood Hits	282	Target Neighborhood Hits	476	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

ARHG6_HUMAN
θ value	0.0736092 (rank : 130)	NC score	0.319987 (rank : 89)
Query Neighborhood Hits	282	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CTRO_MOUSE
θ value	0.0736092 (rank : 131)	NC score	0.030448 (rank : 321)
Query Neighborhood Hits	282	Target Neighborhood Hits	2344	Shared Neighborhood Hits	89
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

NFH_MOUSE
θ value	0.0736092 (rank : 132)	NC score	0.031057 (rank : 318)
Query Neighborhood Hits	282	Target Neighborhood Hits	2247	Shared Neighborhood Hits	107
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SWP70_HUMAN
θ value	0.0736092 (rank : 133)	NC score	0.121661 (rank : 124)
Query Neighborhood Hits	282	Target Neighborhood Hits	973	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GOGA3_MOUSE
θ value	0.0961366 (rank : 134)	NC score	0.061993 (rank : 200)
Query Neighborhood Hits	282	Target Neighborhood Hits	1437	Shared Neighborhood Hits	64
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

NRIP1_HUMAN
θ value	0.0961366 (rank : 135)	NC score	0.028891 (rank : 327)
Query Neighborhood Hits	282	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

TRI66_HUMAN
θ value	0.125558 (rank : 136)	NC score	0.021691 (rank : 341)
Query Neighborhood Hits	282	Target Neighborhood Hits	479	Shared Neighborhood Hits	24
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

PCLO_HUMAN
θ value	0.163984 (rank : 137)	NC score	0.051144 (rank : 285)
Query Neighborhood Hits	282	Target Neighborhood Hits	2046	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

REPS1_MOUSE
θ value	0.163984 (rank : 138)	NC score	0.069788 (rank : 173)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

C43BP_HUMAN
θ value	0.279714 (rank : 139)	NC score	0.096411 (rank : 135)
Query Neighborhood Hits	282	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	0.279714 (rank : 140)	NC score	0.097721 (rank : 134)
Query Neighborhood Hits	282	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

ENL_HUMAN
θ value	0.279714 (rank : 141)	NC score	0.033518 (rank : 315)
Query Neighborhood Hits	282	Target Neighborhood Hits	305	Shared Neighborhood Hits	25
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

FSTL1_MOUSE
θ value	0.279714 (rank : 142)	NC score	0.040379 (rank : 304)
Query Neighborhood Hits	282	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

MAP9_MOUSE
θ value	0.279714 (rank : 143)	NC score	0.039118 (rank : 308)
Query Neighborhood Hits	282	Target Neighborhood Hits	529	Shared Neighborhood Hits	36
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

SRRM1_MOUSE
θ value	0.279714 (rank : 144)	NC score	0.039967 (rank : 305)
Query Neighborhood Hits	282	Target Neighborhood Hits	966	Shared Neighborhood Hits	54
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ZN318_HUMAN
θ value	0.279714 (rank : 145)	NC score	0.052142 (rank : 274)
Query Neighborhood Hits	282	Target Neighborhood Hits	497	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ANK2_HUMAN
θ value	0.365318 (rank : 146)	NC score	0.024812 (rank : 335)
Query Neighborhood Hits	282	Target Neighborhood Hits	1615	Shared Neighborhood Hits	78
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CYH3_HUMAN
θ value	0.365318 (rank : 147)	NC score	0.088839 (rank : 145)
Query Neighborhood Hits	282	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

FSTL1_HUMAN
θ value	0.365318 (rank : 148)	NC score	0.039379 (rank : 307)
Query Neighborhood Hits	282	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

IQEC3_HUMAN
θ value	0.365318 (rank : 149)	NC score	0.057272 (rank : 235)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

OSBL9_HUMAN
θ value	0.365318 (rank : 150)	NC score	0.101709 (rank : 129)
Query Neighborhood Hits	282	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PHLB2_MOUSE
θ value	0.365318 (rank : 151)	NC score	0.062885 (rank : 190)
Query Neighborhood Hits	282	Target Neighborhood Hits	1016	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PKHA2_MOUSE
θ value	0.365318 (rank : 152)	NC score	0.101421 (rank : 130)
Query Neighborhood Hits	282	Target Neighborhood Hits	116	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

TCOF_HUMAN
θ value	0.365318 (rank : 153)	NC score	0.038529 (rank : 310)
Query Neighborhood Hits	282	Target Neighborhood Hits	543	Shared Neighborhood Hits	45
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TNR25_HUMAN
θ value	0.365318 (rank : 154)	NC score	0.030431 (rank : 322)
Query Neighborhood Hits	282	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

ZN318_MOUSE
θ value	0.365318 (rank : 155)	NC score	0.044753 (rank : 298)
Query Neighborhood Hits	282	Target Neighborhood Hits	642	Shared Neighborhood Hits	45
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

OSB11_MOUSE
θ value	0.47712 (rank : 156)	NC score	0.045115 (rank : 297)
Query Neighborhood Hits	282	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

TAB2_HUMAN
θ value	0.47712 (rank : 157)	NC score	0.033355 (rank : 316)
Query Neighborhood Hits	282	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

M3K11_HUMAN
θ value	0.62314 (rank : 158)	NC score	0.018618 (rank : 354)
Query Neighborhood Hits	282	Target Neighborhood Hits	1136	Shared Neighborhood Hits	49
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NUMA1_HUMAN
θ value	0.62314 (rank : 159)	NC score	0.049601 (rank : 291)
Query Neighborhood Hits	282	Target Neighborhood Hits	1523	Shared Neighborhood Hits	69
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RFTN1_MOUSE
θ value	0.62314 (rank : 160)	NC score	0.019573 (rank : 350)
Query Neighborhood Hits	282	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A0D4, Q3U654, Q3U8P6, Q80US1	Gene names	Rftn1, Kiaa0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein).

SH2D3_HUMAN
θ value	0.62314 (rank : 161)	NC score	0.021216 (rank : 345)
Query Neighborhood Hits	282	Target Neighborhood Hits	188	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SYTL2_MOUSE
θ value	0.62314 (rank : 162)	NC score	0.016611 (rank : 357)
Query Neighborhood Hits	282	Target Neighborhood Hits	253	Shared Neighborhood Hits	16
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

TAB2_MOUSE
θ value	0.62314 (rank : 163)	NC score	0.032453 (rank : 317)
Query Neighborhood Hits	282	Target Neighborhood Hits	245	Shared Neighborhood Hits	19
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

TACC2_MOUSE
θ value	0.62314 (rank : 164)	NC score	0.051167 (rank : 284)
Query Neighborhood Hits	282	Target Neighborhood Hits	774	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ZFY27_MOUSE
θ value	0.62314 (rank : 165)	NC score	0.223753 (rank : 104)
Query Neighborhood Hits	282	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FACD2_HUMAN
θ value	0.813845 (rank : 166)	NC score	0.025354 (rank : 334)
Query Neighborhood Hits	282	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

IQEC3_MOUSE
θ value	0.813845 (rank : 167)	NC score	0.051220 (rank : 283)
Query Neighborhood Hits	282	Target Neighborhood Hits	274	Shared Neighborhood Hits	33
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K1543_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.024195 (rank : 337)
Query Neighborhood Hits	282	Target Neighborhood Hits	435	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

RASA3_MOUSE
θ value	0.813845 (rank : 169)	NC score	0.030591 (rank : 320)
Query Neighborhood Hits	282	Target Neighborhood Hits	144	Shared Neighborhood Hits	27
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

SPTB2_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.045304 (rank : 296)
Query Neighborhood Hits	282	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CAMKV_HUMAN
θ value	1.06291 (rank : 171)	NC score	0.008453 (rank : 387)
Query Neighborhood Hits	282	Target Neighborhood Hits	1084	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CEND1_MOUSE
θ value	1.06291 (rank : 172)	NC score	0.048819 (rank : 293)
Query Neighborhood Hits	282	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

K1802_MOUSE
θ value	1.06291 (rank : 173)	NC score	0.029223 (rank : 325)
Query Neighborhood Hits	282	Target Neighborhood Hits	1596	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MCM4_HUMAN
θ value	1.06291 (rank : 174)	NC score	0.015162 (rank : 365)
Query Neighborhood Hits	282	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

MDC1_HUMAN
θ value	1.06291 (rank : 175)	NC score	0.040492 (rank : 303)
Query Neighborhood Hits	282	Target Neighborhood Hits	1446	Shared Neighborhood Hits	76
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RHG25_HUMAN
θ value	1.06291 (rank : 176)	NC score	0.068284 (rank : 175)
Query Neighborhood Hits	282	Target Neighborhood Hits	550	Shared Neighborhood Hits	67
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SON_HUMAN
θ value	1.06291 (rank : 177)	NC score	0.030309 (rank : 323)
Query Neighborhood Hits	282	Target Neighborhood Hits	1568	Shared Neighborhood Hits	76
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ZC3H6_HUMAN
θ value	1.06291 (rank : 178)	NC score	0.017777 (rank : 356)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

2AAB_HUMAN
θ value	1.38821 (rank : 179)	NC score	0.015838 (rank : 363)
Query Neighborhood Hits	282	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

CAPS2_MOUSE
θ value	1.38821 (rank : 180)	NC score	0.020410 (rank : 347)
Query Neighborhood Hits	282	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

EGR4_HUMAN
θ value	1.38821 (rank : 181)	NC score	-0.005681 (rank : 418)
Query Neighborhood Hits	282	Target Neighborhood Hits	939	Shared Neighborhood Hits	17
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

K2002_MOUSE
θ value	1.38821 (rank : 182)	NC score	0.026322 (rank : 332)
Query Neighborhood Hits	282	Target Neighborhood Hits	267	Shared Neighborhood Hits	11
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PHLB1_HUMAN
θ value	1.38821 (rank : 183)	NC score	0.058022 (rank : 229)
Query Neighborhood Hits	282	Target Neighborhood Hits	1038	Shared Neighborhood Hits	76
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

YTHD2_HUMAN
θ value	1.38821 (rank : 184)	NC score	0.011522 (rank : 377)
Query Neighborhood Hits	282	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

ZFY27_HUMAN
θ value	1.38821 (rank : 185)	NC score	0.217934 (rank : 105)
Query Neighborhood Hits	282	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

BAG3_HUMAN
θ value	1.81305 (rank : 186)	NC score	0.021037 (rank : 346)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	28
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

NFH_HUMAN
θ value	1.81305 (rank : 187)	NC score	0.023446 (rank : 338)
Query Neighborhood Hits	282	Target Neighborhood Hits	1242	Shared Neighborhood Hits	72
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PO6F2_HUMAN
θ value	1.81305 (rank : 188)	NC score	0.006537 (rank : 398)
Query Neighborhood Hits	282	Target Neighborhood Hits	618	Shared Neighborhood Hits	27
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

SPTB2_MOUSE
θ value	1.81305 (rank : 189)	NC score	0.043906 (rank : 300)
Query Neighborhood Hits	282	Target Neighborhood Hits	770	Shared Neighborhood Hits	58
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CEND1_HUMAN
θ value	2.36792 (rank : 190)	NC score	0.052921 (rank : 269)
Query Neighborhood Hits	282	Target Neighborhood Hits	284	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CJ006_HUMAN
θ value	2.36792 (rank : 191)	NC score	0.015074 (rank : 366)
Query Neighborhood Hits	282	Target Neighborhood Hits	122	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

FOXN4_MOUSE
θ value	2.36792 (rank : 192)	NC score	0.004084 (rank : 408)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

GRB7_MOUSE
θ value	2.36792 (rank : 193)	NC score	0.019205 (rank : 352)
Query Neighborhood Hits	282	Target Neighborhood Hits	157	Shared Neighborhood Hits	14
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

K1683_HUMAN
θ value	2.36792 (rank : 194)	NC score	0.026943 (rank : 331)
Query Neighborhood Hits	282	Target Neighborhood Hits	240	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

SEPN1_HUMAN
θ value	2.36792 (rank : 195)	NC score	0.019775 (rank : 349)
Query Neighborhood Hits	282	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV5, Q6PI70, Q969F6, Q9NUI6	Gene names	SEPN1, SELN
Domain Architecture	No domain graphic available
Description	Selenoprotein N precursor.

SPTN4_HUMAN
θ value	2.36792 (rank : 196)	NC score	0.037417 (rank : 311)
Query Neighborhood Hits	282	Target Neighborhood Hits	570	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

TAF4_HUMAN
θ value	2.36792 (rank : 197)	NC score	0.044168 (rank : 299)
Query Neighborhood Hits	282	Target Neighborhood Hits	687	Shared Neighborhood Hits	41
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARSH_HUMAN
θ value	2.36792 (rank : 198)	NC score	0.039723 (rank : 306)
Query Neighborhood Hits	282	Target Neighborhood Hits	768	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TF2AY_MOUSE
θ value	2.36792 (rank : 199)	NC score	0.012863 (rank : 374)
Query Neighborhood Hits	282	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

ZCHC6_MOUSE
θ value	2.36792 (rank : 200)	NC score	0.010046 (rank : 380)
Query Neighborhood Hits	282	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q5BLK4, Q8CIH3	Gene names	Zcchc6
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

BSN_MOUSE
θ value	3.0926 (rank : 201)	NC score	0.051258 (rank : 282)
Query Neighborhood Hits	282	Target Neighborhood Hits	2057	Shared Neighborhood Hits	100
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

ETV3_MOUSE
θ value	3.0926 (rank : 202)	NC score	0.007846 (rank : 393)
Query Neighborhood Hits	282	Target Neighborhood Hits	128	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4Z4, Q9QZW1	Gene names	Etv3, Mets, Pe1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

ITK_HUMAN
θ value	3.0926 (rank : 203)	NC score	0.008584 (rank : 386)
Query Neighborhood Hits	282	Target Neighborhood Hits	1016	Shared Neighborhood Hits	47
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

K0319_HUMAN
θ value	3.0926 (rank : 204)	NC score	0.014793 (rank : 369)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

KS6B2_MOUSE
θ value	3.0926 (rank : 205)	NC score	0.002392 (rank : 409)
Query Neighborhood Hits	282	Target Neighborhood Hits	871	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

MINK1_HUMAN
θ value	3.0926 (rank : 206)	NC score	0.008589 (rank : 385)
Query Neighborhood Hits	282	Target Neighborhood Hits	1477	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

OSBP1_HUMAN
θ value	3.0926 (rank : 207)	NC score	0.042932 (rank : 301)
Query Neighborhood Hits	282	Target Neighborhood Hits	180	Shared Neighborhood Hits	41
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PCD15_HUMAN
θ value	3.0926 (rank : 208)	NC score	0.000721 (rank : 411)
Query Neighborhood Hits	282	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

PDE2A_MOUSE
θ value	3.0926 (rank : 209)	NC score	0.007878 (rank : 392)
Query Neighborhood Hits	282	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PHLB2_HUMAN
θ value	3.0926 (rank : 210)	NC score	0.057544 (rank : 232)
Query Neighborhood Hits	282	Target Neighborhood Hits	964	Shared Neighborhood Hits	72
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PRG4_MOUSE
θ value	3.0926 (rank : 211)	NC score	0.036116 (rank : 312)
Query Neighborhood Hits	282	Target Neighborhood Hits	624	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RFFL_MOUSE
θ value	3.0926 (rank : 212)	NC score	0.071467 (rank : 170)
Query Neighborhood Hits	282	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

TRI66_MOUSE
θ value	3.0926 (rank : 213)	NC score	0.022126 (rank : 340)
Query Neighborhood Hits	282	Target Neighborhood Hits	491	Shared Neighborhood Hits	28
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ZEP2_HUMAN
θ value	3.0926 (rank : 214)	NC score	-0.001634 (rank : 413)
Query Neighborhood Hits	282	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ATRX_HUMAN
θ value	4.03905 (rank : 215)	NC score	0.013982 (rank : 371)
Query Neighborhood Hits	282	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

CDR2_HUMAN
θ value	4.03905 (rank : 216)	NC score	0.034953 (rank : 314)
Query Neighborhood Hits	282	Target Neighborhood Hits	404	Shared Neighborhood Hits	30
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

DCC_MOUSE
θ value	4.03905 (rank : 217)	NC score	0.006630 (rank : 397)
Query Neighborhood Hits	282	Target Neighborhood Hits	896	Shared Neighborhood Hits	25
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

MAST2_MOUSE
θ value	4.03905 (rank : 218)	NC score	0.005464 (rank : 402)
Query Neighborhood Hits	282	Target Neighborhood Hits	1110	Shared Neighborhood Hits	33
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PHLB1_MOUSE
θ value	4.03905 (rank : 219)	NC score	0.048110 (rank : 294)
Query Neighborhood Hits	282	Target Neighborhood Hits	678	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

REXO1_MOUSE
θ value	4.03905 (rank : 220)	NC score	0.016199 (rank : 359)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

RHG25_MOUSE
θ value	4.03905 (rank : 221)	NC score	0.068606 (rank : 174)
Query Neighborhood Hits	282	Target Neighborhood Hits	492	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TERT_HUMAN
θ value	4.03905 (rank : 222)	NC score	0.010497 (rank : 378)
Query Neighborhood Hits	282	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	O14746, O14783, Q2XS35, Q8N6C3	Gene names	TERT, EST2, TCS1, TRT
Domain Architecture	No domain graphic available
Description	Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (HEST2) (Telomerase-associated protein 2) (TP2).

USP9X_HUMAN
θ value	4.03905 (rank : 223)	NC score	0.008184 (rank : 388)
Query Neighborhood Hits	282	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
θ value	4.03905 (rank : 224)	NC score	0.008126 (rank : 389)
Query Neighborhood Hits	282	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

AFF1_MOUSE
θ value	5.27518 (rank : 225)	NC score	0.029123 (rank : 326)
Query Neighborhood Hits	282	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

B2L13_HUMAN
θ value	5.27518 (rank : 226)	NC score	0.016178 (rank : 360)
Query Neighborhood Hits	282	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BXK5, Q96B37, Q96IB7, Q9BY01, Q9HC05, Q9UFE0, Q9UKN3	Gene names	BCL2L13, MIL1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

CAPS2_HUMAN
θ value	5.27518 (rank : 227)	NC score	0.016150 (rank : 361)
Query Neighborhood Hits	282	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

CTRO_HUMAN
θ value	5.27518 (rank : 228)	NC score	0.024776 (rank : 336)
Query Neighborhood Hits	282	Target Neighborhood Hits	2092	Shared Neighborhood Hits	82
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DPOD3_MOUSE
θ value	5.27518 (rank : 229)	NC score	0.014803 (rank : 368)
Query Neighborhood Hits	282	Target Neighborhood Hits	118	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQ28	Gene names	Pold3
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

FYB_HUMAN
θ value	5.27518 (rank : 230)	NC score	0.022401 (rank : 339)
Query Neighborhood Hits	282	Target Neighborhood Hits	379	Shared Neighborhood Hits	31
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GCP6_HUMAN
θ value	5.27518 (rank : 231)	NC score	0.021644 (rank : 343)
Query Neighborhood Hits	282	Target Neighborhood Hits	295	Shared Neighborhood Hits	22
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

IWS1_HUMAN
θ value	5.27518 (rank : 232)	NC score	0.020124 (rank : 348)
Query Neighborhood Hits	282	Target Neighborhood Hits	1241	Shared Neighborhood Hits	64
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MAGE1_HUMAN
θ value	5.27518 (rank : 233)	NC score	0.021672 (rank : 342)
Query Neighborhood Hits	282	Target Neighborhood Hits	1389	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP1B_HUMAN
θ value	5.27518 (rank : 234)	NC score	0.028309 (rank : 328)
Query Neighborhood Hits	282	Target Neighborhood Hits	903	Shared Neighborhood Hits	53
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

PCDB7_HUMAN
θ value	5.27518 (rank : 235)	NC score	-0.002006 (rank : 415)
Query Neighborhood Hits	282	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5E2	Gene names	PCDHB7
Domain Architecture
Description	Protocadherin beta 7 precursor (PCDH-beta7).

RAD52_MOUSE
θ value	5.27518 (rank : 236)	NC score	0.010486 (rank : 379)
Query Neighborhood Hits	282	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P43352	Gene names	Rad52
Domain Architecture
Description	DNA repair protein RAD52 homolog.

RASA3_HUMAN
θ value	5.27518 (rank : 237)	NC score	0.030275 (rank : 324)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

RC3H1_HUMAN
θ value	5.27518 (rank : 238)	NC score	0.014004 (rank : 370)
Query Neighborhood Hits	282	Target Neighborhood Hits	433	Shared Neighborhood Hits	18
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RC3H1_MOUSE
θ value	5.27518 (rank : 239)	NC score	0.014804 (rank : 367)
Query Neighborhood Hits	282	Target Neighborhood Hits	244	Shared Neighborhood Hits	15
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

REEP2_MOUSE
θ value	5.27518 (rank : 240)	NC score	0.013518 (rank : 372)
Query Neighborhood Hits	282	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCD6	Gene names	Reep2
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 2.

SHAN2_HUMAN
θ value	5.27518 (rank : 241)	NC score	0.021326 (rank : 344)
Query Neighborhood Hits	282	Target Neighborhood Hits	346	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

ZN690_HUMAN
θ value	5.27518 (rank : 242)	NC score	-0.007116 (rank : 419)
Query Neighborhood Hits	282	Target Neighborhood Hits	777	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWY8, Q32M75, Q32M76, Q8NA40	Gene names	ZNF690
Domain Architecture	No domain graphic available
Description	Zinc finger protein 690.

AXUD1_MOUSE
θ value	6.88961 (rank : 243)	NC score	0.005455 (rank : 403)
Query Neighborhood Hits	282	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P59054	Gene names	Axud1, Taip3
Domain Architecture	No domain graphic available
Description	Axin-1 up-regulated gene 1 protein (TGF-beta-induced apoptosis protein 3) (TAIP-3).

BCAS1_MOUSE
θ value	6.88961 (rank : 244)	NC score	0.013430 (rank : 373)
Query Neighborhood Hits	282	Target Neighborhood Hits	215	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YN3, Q9CVA1	Gene names	Bcas1, Nabc1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 homolog (Novel amplified in breast cancer 1 homolog).

CAC1D_HUMAN
θ value	6.88961 (rank : 245)	NC score	0.000898 (rank : 410)
Query Neighborhood Hits	282	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CD5R2_HUMAN
θ value	6.88961 (rank : 246)	NC score	0.007973 (rank : 390)
Query Neighborhood Hits	282	Target Neighborhood Hits	53	Shared Neighborhood Hits	9
SwissProt Accessions	Q13319, Q4ZFW6	Gene names	CDK5R2, NCK5AI
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

EST1A_MOUSE
θ value	6.88961 (rank : 247)	NC score	0.006107 (rank : 399)
Query Neighborhood Hits	282	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

EXDL2_MOUSE
θ value	6.88961 (rank : 248)	NC score	0.007771 (rank : 394)
Query Neighborhood Hits	282	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

GRB7_HUMAN
θ value	6.88961 (rank : 249)	NC score	0.018203 (rank : 355)
Query Neighborhood Hits	282	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

MAST2_HUMAN
θ value	6.88961 (rank : 250)	NC score	0.005252 (rank : 405)
Query Neighborhood Hits	282	Target Neighborhood Hits	1189	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MBD4_MOUSE
θ value	6.88961 (rank : 251)	NC score	0.009513 (rank : 382)
Query Neighborhood Hits	282	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2D7, Q792D2, Q8R3R3	Gene names	Mbd4
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase).

MLL3_MOUSE
θ value	6.88961 (rank : 252)	NC score	0.016214 (rank : 358)
Query Neighborhood Hits	282	Target Neighborhood Hits	1399	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NKTR_HUMAN
θ value	6.88961 (rank : 253)	NC score	0.005272 (rank : 404)
Query Neighborhood Hits	282	Target Neighborhood Hits	658	Shared Neighborhood Hits	24
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

NOG2_HUMAN
θ value	6.88961 (rank : 254)	NC score	0.012805 (rank : 375)
Query Neighborhood Hits	282	Target Neighborhood Hits	117	Shared Neighborhood Hits	11
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

NOG2_MOUSE
θ value	6.88961 (rank : 255)	NC score	0.009471 (rank : 383)
Query Neighborhood Hits	282	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

PHAR3_MOUSE
θ value	6.88961 (rank : 256)	NC score	0.006105 (rank : 400)
Query Neighborhood Hits	282	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

PKHA2_HUMAN
θ value	6.88961 (rank : 257)	NC score	0.085867 (rank : 148)
Query Neighborhood Hits	282	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PRR8_HUMAN
θ value	6.88961 (rank : 258)	NC score	0.019234 (rank : 351)
Query Neighborhood Hits	282	Target Neighborhood Hits	217	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

STAB1_HUMAN
θ value	6.88961 (rank : 259)	NC score	-0.003181 (rank : 417)
Query Neighborhood Hits	282	Target Neighborhood Hits	546	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

ZBT26_HUMAN
θ value	6.88961 (rank : 260)	NC score	-0.007543 (rank : 420)
Query Neighborhood Hits	282	Target Neighborhood Hits	784	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCK0, Q8WTR1	Gene names	ZBTB26, KIAA1572, ZNF481
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref).

AL2SA_HUMAN
θ value	8.99809 (rank : 261)	NC score	0.009830 (rank : 381)
Query Neighborhood Hits	282	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q53TS8, Q8NCN6, Q96LN4	Gene names	ALS2CR11
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein.

ATS20_HUMAN
θ value	8.99809 (rank : 262)	NC score	-0.001657 (rank : 414)
Query Neighborhood Hits	282	Target Neighborhood Hits	192	Shared Neighborhood Hits	3
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

B2L13_MOUSE
θ value	8.99809 (rank : 263)	NC score	0.012767 (rank : 376)
Query Neighborhood Hits	282	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P59017	Gene names	Bcl2l13, Mil1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

CA156_HUMAN
θ value	8.99809 (rank : 264)	NC score	0.006963 (rank : 396)
Query Neighborhood Hits	282	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O95568	Gene names	C1orf156, ASTP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf156 (Arsenic-transactivated protein 2) (AsTP2).

CENB1_HUMAN
θ value	8.99809 (rank : 265)	NC score	0.030635 (rank : 319)
Query Neighborhood Hits	282	Target Neighborhood Hits	383	Shared Neighborhood Hits	38
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CYH1_HUMAN
θ value	8.99809 (rank : 266)	NC score	0.085074 (rank : 149)
Query Neighborhood Hits	282	Target Neighborhood Hits	184	Shared Neighborhood Hits	62
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	8.99809 (rank : 267)	NC score	0.082243 (rank : 152)
Query Neighborhood Hits	282	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DAF1_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.004325 (rank : 407)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

ETV3_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.008654 (rank : 384)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

MILK1_HUMAN
θ value	8.99809 (rank : 270)	NC score	0.026016 (rank : 333)
Query Neighborhood Hits	282	Target Neighborhood Hits	427	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MUC1_HUMAN
θ value	8.99809 (rank : 271)	NC score	0.018883 (rank : 353)
Query Neighborhood Hits	282	Target Neighborhood Hits	975	Shared Neighborhood Hits	49
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MYH10_HUMAN
θ value	8.99809 (rank : 272)	NC score	0.028172 (rank : 330)
Query Neighborhood Hits	282	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	8.99809 (rank : 273)	NC score	0.028266 (rank : 329)
Query Neighborhood Hits	282	Target Neighborhood Hits	1612	Shared Neighborhood Hits	67
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NKX61_HUMAN
θ value	8.99809 (rank : 274)	NC score	-0.002176 (rank : 416)
Query Neighborhood Hits	282	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	P78426	Gene names	NKX6-1, NKX6A
Domain Architecture
Description	Homeobox protein Nkx-6.1.

PSD4_HUMAN
θ value	8.99809 (rank : 275)	NC score	0.045913 (rank : 295)
Query Neighborhood Hits	282	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RRBP1_MOUSE
θ value	8.99809 (rank : 276)	NC score	0.035097 (rank : 313)
Query Neighborhood Hits	282	Target Neighborhood Hits	1650	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

RTN4_MOUSE
θ value	8.99809 (rank : 277)	NC score	0.015934 (rank : 362)
Query Neighborhood Hits	282	Target Neighborhood Hits	341	Shared Neighborhood Hits	34
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SC24C_HUMAN
θ value	8.99809 (rank : 278)	NC score	0.007972 (rank : 391)
Query Neighborhood Hits	282	Target Neighborhood Hits	662	Shared Neighborhood Hits	32
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TF3C2_HUMAN
θ value	8.99809 (rank : 279)	NC score	0.005479 (rank : 401)
Query Neighborhood Hits	282	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

THAS_MOUSE
θ value	8.99809 (rank : 280)	NC score	-0.001323 (rank : 412)
Query Neighborhood Hits	282	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P36423, P97505	Gene names	Tbxas1, Cyp5, Cyp5a1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (TS) (Cytochrome P450 5A1).

TM108_HUMAN
θ value	8.99809 (rank : 281)	NC score	0.015838 (rank : 364)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

UBE4A_HUMAN
θ value	8.99809 (rank : 282)	NC score	0.007320 (rank : 395)
Query Neighborhood Hits	282	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q14139, Q6P5T4, Q7Z639	Gene names	UBE4A, KIAA0126
Domain Architecture	No domain graphic available
Description	Ubiquitin conjugation factor E4 A.

3BP2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.077502 (rank : 161)
Query Neighborhood Hits	282	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.071863 (rank : 169)
Query Neighborhood Hits	282	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.062454 (rank : 194)
Query Neighborhood Hits	282	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.061620 (rank : 204)
Query Neighborhood Hits	282	Target Neighborhood Hits	184	Shared Neighborhood Hits	16
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.058492 (rank : 226)
Query Neighborhood Hits	282	Target Neighborhood Hits	257	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.061077 (rank : 208)
Query Neighborhood Hits	282	Target Neighborhood Hits	246	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.065397 (rank : 180)
Query Neighborhood Hits	282	Target Neighborhood Hits	350	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.063591 (rank : 186)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.055886 (rank : 245)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.055360 (rank : 253)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.057410 (rank : 233)
Query Neighborhood Hits	282	Target Neighborhood Hits	537	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.051286 (rank : 281)
Query Neighborhood Hits	282	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.380091 (rank : 70)
Query Neighborhood Hits	282	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG3_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.405452 (rank : 61)
Query Neighborhood Hits	282	Target Neighborhood Hits	82	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.405308 (rank : 62)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG7_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.353714 (rank : 85)
Query Neighborhood Hits	282	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.375104 (rank : 73)
Query Neighborhood Hits	282	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ASPP1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.051862 (rank : 277)
Query Neighborhood Hits	282	Target Neighborhood Hits	1244	Shared Neighborhood Hits	80
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BI2L1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.064955 (rank : 182)
Query Neighborhood Hits	282	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.054262 (rank : 260)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BSN_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.053113 (rank : 267)
Query Neighborhood Hits	282	Target Neighborhood Hits	1537	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CCD96_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.051886 (rank : 276)
Query Neighborhood Hits	282	Target Neighborhood Hits	704	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CD2AP_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.091426 (rank : 144)
Query Neighborhood Hits	282	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.091453 (rank : 143)
Query Neighborhood Hits	282	Target Neighborhood Hits	336	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CJ064_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.054963 (rank : 255)
Query Neighborhood Hits	282	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

CRKL_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.059951 (rank : 217)
Query Neighborhood Hits	282	Target Neighborhood Hits	313	Shared Neighborhood Hits	24
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.058294 (rank : 227)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.053092 (rank : 268)
Query Neighborhood Hits	282	Target Neighborhood Hits	308	Shared Neighborhood Hits	26
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.055578 (rank : 248)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CYH2_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.078401 (rank : 160)
Query Neighborhood Hits	282	Target Neighborhood Hits	175	Shared Neighborhood Hits	56
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.078409 (rank : 159)
Query Neighborhood Hits	282	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DBNL_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.051706 (rank : 279)
Query Neighborhood Hits	282	Target Neighborhood Hits	244	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DGKH_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.062569 (rank : 193)
Query Neighborhood Hits	282	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

E41L1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.060738 (rank : 211)
Query Neighborhood Hits	282	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.059721 (rank : 219)
Query Neighborhood Hits	282	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.059403 (rank : 220)
Query Neighborhood Hits	282	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.062059 (rank : 199)
Query Neighborhood Hits	282	Target Neighborhood Hits	459	Shared Neighborhood Hits	27
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.062436 (rank : 195)
Query Neighborhood Hits	282	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.061109 (rank : 207)
Query Neighborhood Hits	282	Target Neighborhood Hits	250	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.062104 (rank : 197)
Query Neighborhood Hits	282	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.057140 (rank : 236)
Query Neighborhood Hits	282	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.055900 (rank : 244)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.063028 (rank : 189)
Query Neighborhood Hits	282	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.061945 (rank : 201)
Query Neighborhood Hits	282	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.051971 (rank : 275)
Query Neighborhood Hits	282	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EP15R_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.060642 (rank : 213)
Query Neighborhood Hits	282	Target Neighborhood Hits	1083	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.060175 (rank : 215)
Query Neighborhood Hits	282	Target Neighborhood Hits	1135	Shared Neighborhood Hits	55
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.059238 (rank : 221)
Query Neighborhood Hits	282	Target Neighborhood Hits	1021	Shared Neighborhood Hits	52
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.056268 (rank : 243)
Query Neighborhood Hits	282	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EZRI_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.054416 (rank : 259)
Query Neighborhood Hits	282	Target Neighborhood Hits	663	Shared Neighborhood Hits	37
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.054958 (rank : 256)
Query Neighborhood Hits	282	Target Neighborhood Hits	693	Shared Neighborhood Hits	38
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FNBP2_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.053894 (rank : 263)
Query Neighborhood Hits	282	Target Neighborhood Hits	432	Shared Neighborhood Hits	42
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.060128 (rank : 216)
Query Neighborhood Hits	282	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.060669 (rank : 212)
Query Neighborhood Hits	282	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRAP2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.061148 (rank : 206)
Query Neighborhood Hits	282	Target Neighborhood Hits	304	Shared Neighborhood Hits	25
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.060762 (rank : 210)
Query Neighborhood Hits	282	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.076446 (rank : 164)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.075535 (rank : 166)
Query Neighborhood Hits	282	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.067446 (rank : 177)
Query Neighborhood Hits	282	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.067407 (rank : 178)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.062089 (rank : 198)
Query Neighborhood Hits	282	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.063688 (rank : 184)
Query Neighborhood Hits	282	Target Neighborhood Hits	329	Shared Neighborhood Hits	34
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MERL_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.053715 (rank : 265)
Query Neighborhood Hits	282	Target Neighborhood Hits	532	Shared Neighborhood Hits	29
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.054113 (rank : 261)
Query Neighborhood Hits	282	Target Neighborhood Hits	524	Shared Neighborhood Hits	29
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MOES_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.058642 (rank : 223)
Query Neighborhood Hits	282	Target Neighborhood Hits	892	Shared Neighborhood Hits	43
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.059182 (rank : 222)
Query Neighborhood Hits	282	Target Neighborhood Hits	923	Shared Neighborhood Hits	40
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYLIP_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.052254 (rank : 273)
Query Neighborhood Hits	282	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.052548 (rank : 271)
Query Neighborhood Hits	282	Target Neighborhood Hits	139	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NCF1_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.100146 (rank : 133)
Query Neighborhood Hits	282	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 352)	NC score	0.094819 (rank : 136)
Query Neighborhood Hits	282	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.083869 (rank : 150)
Query Neighborhood Hits	282	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.070945 (rank : 171)
Query Neighborhood Hits	282	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.070190 (rank : 172)
Query Neighborhood Hits	282	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.081585 (rank : 153)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.078937 (rank : 157)
Query Neighborhood Hits	282	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.055522 (rank : 249)
Query Neighborhood Hits	282	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.051670 (rank : 280)
Query Neighborhood Hits	282	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.053168 (rank : 266)
Query Neighborhood Hits	282	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.050284 (rank : 288)
Query Neighborhood Hits	282	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.050831 (rank : 286)
Query Neighborhood Hits	282	Target Neighborhood Hits	466	Shared Neighborhood Hits	26
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.050236 (rank : 289)
Query Neighborhood Hits	282	Target Neighborhood Hits	467	Shared Neighborhood Hits	26
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PKHA1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.065079 (rank : 181)
Query Neighborhood Hits	282	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.063645 (rank : 185)
Query Neighborhood Hits	282	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.056438 (rank : 242)
Query Neighborhood Hits	282	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.058111 (rank : 228)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	28
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLEK2_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.055272 (rank : 254)
Query Neighborhood Hits	282	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.055393 (rank : 252)
Query Neighborhood Hits	282	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.082711 (rank : 151)
Query Neighborhood Hits	282	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.075901 (rank : 165)
Query Neighborhood Hits	282	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PPIP1_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.061811 (rank : 202)
Query Neighborhood Hits	282	Target Neighborhood Hits	389	Shared Neighborhood Hits	32
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.061737 (rank : 203)
Query Neighborhood Hits	282	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RADI_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.058532 (rank : 225)
Query Neighborhood Hits	282	Target Neighborhood Hits	741	Shared Neighborhood Hits	41
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.057593 (rank : 231)
Query Neighborhood Hits	282	Target Neighborhood Hits	773	Shared Neighborhood Hits	40
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

REPS1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.054805 (rank : 257)
Query Neighborhood Hits	282	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.058554 (rank : 224)
Query Neighborhood Hits	282	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.056653 (rank : 238)
Query Neighborhood Hits	282	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RFFL_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.060556 (rank : 214)
Query Neighborhood Hits	282	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFIP3_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.050290 (rank : 287)
Query Neighborhood Hits	282	Target Neighborhood Hits	1055	Shared Neighborhood Hits	61
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RHG04_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.055475 (rank : 251)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.052911 (rank : 270)
Query Neighborhood Hits	282	Target Neighborhood Hits	1479	Shared Neighborhood Hits	86
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RNF34_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.063063 (rank : 188)
Query Neighborhood Hits	282	Target Neighborhood Hits	153	Shared Neighborhood Hits	30
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.068140 (rank : 176)
Query Neighborhood Hits	282	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RUFY3_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.091686 (rank : 140)
Query Neighborhood Hits	282	Target Neighborhood Hits	594	Shared Neighborhood Hits	30
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.092255 (rank : 138)
Query Neighborhood Hits	282	Target Neighborhood Hits	579	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.056574 (rank : 240)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.053803 (rank : 264)
Query Neighborhood Hits	282	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.057828 (rank : 230)
Query Neighborhood Hits	282	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.055773 (rank : 247)
Query Neighborhood Hits	282	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.055843 (rank : 246)
Query Neighborhood Hits	282	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.057274 (rank : 234)
Query Neighborhood Hits	282	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.100486 (rank : 131)
Query Neighborhood Hits	282	Target Neighborhood Hits	341	Shared Neighborhood Hits	40
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.091476 (rank : 142)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.056610 (rank : 239)
Query Neighborhood Hits	282	Target Neighborhood Hits	446	Shared Neighborhood Hits	52
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOS1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.217047 (rank : 106)
Query Neighborhood Hits	282	Target Neighborhood Hits	274	Shared Neighborhood Hits	60
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.202411 (rank : 110)
Query Neighborhood Hits	282	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.206533 (rank : 108)
Query Neighborhood Hits	282	Target Neighborhood Hits	193	Shared Neighborhood Hits	54
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.056546 (rank : 241)
Query Neighborhood Hits	282	Target Neighborhood Hits	748	Shared Neighborhood Hits	54
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.055510 (rank : 250)
Query Neighborhood Hits	282	Target Neighborhood Hits	675	Shared Neighborhood Hits	52
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.062704 (rank : 192)
Query Neighborhood Hits	282	Target Neighborhood Hits	888	Shared Neighborhood Hits	60
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.086056 (rank : 147)
Query Neighborhood Hits	282	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.088824 (rank : 146)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	44
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.061392 (rank : 205)
Query Neighborhood Hits	282	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.059901 (rank : 218)
Query Neighborhood Hits	282	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.051795 (rank : 278)
Query Neighborhood Hits	282	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.062221 (rank : 196)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.062760 (rank : 191)
Query Neighborhood Hits	282	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.066118 (rank : 179)
Query Neighborhood Hits	282	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.064408 (rank : 183)
Query Neighborhood Hits	282	Target Neighborhood Hits	268	Shared Neighborhood Hits	24
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.076833 (rank : 163)
Query Neighborhood Hits	282	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.077061 (rank : 162)
Query Neighborhood Hits	282	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.074189 (rank : 167)
Query Neighborhood Hits	282	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.073959 (rank : 168)
Query Neighborhood Hits	282	Target Neighborhood Hits	285	Shared Neighborhood Hits	28
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TARA_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.054720 (rank : 258)
Query Neighborhood Hits	282	Target Neighborhood Hits	1626	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.056804 (rank : 237)
Query Neighborhood Hits	282	Target Neighborhood Hits	1133	Shared Neighborhood Hits	91
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TCGAP_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.060838 (rank : 209)
Query Neighborhood Hits	282	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.063307 (rank : 187)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.081124 (rank : 154)
Query Neighborhood Hits	282	Target Neighborhood Hits	270	Shared Neighborhood Hits	34
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.079815 (rank : 156)
Query Neighborhood Hits	282	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

FGD6_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	282	Target Neighborhood Hits	282	Shared Neighborhood Hits	282
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.984160 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	282	Target Neighborhood Hits	237	Shared Neighborhood Hits	162
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD2_MOUSE
NC score	0.906583 (rank : 3)	θ value	1.96316e-71 (rank : 10)
Query Neighborhood Hits	282	Target Neighborhood Hits	163	Shared Neighborhood Hits	118
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.905543 (rank : 4)	θ value	3.95564e-72 (rank : 9)
Query Neighborhood Hits	282	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD5_HUMAN
NC score	0.902402 (rank : 5)	θ value	4.29305e-135 (rank : 3)
Query Neighborhood Hits	282	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD4_HUMAN
NC score	0.900326 (rank : 6)	θ value	3.81361e-83 (rank : 5)
Query Neighborhood Hits	282	Target Neighborhood Hits	219	Shared Neighborhood Hits	128
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.899390 (rank : 7)	θ value	8.49582e-83 (rank : 6)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	128
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_MOUSE
NC score	0.896220 (rank : 8)	θ value	3.4095e-124 (rank : 4)
Query Neighborhood Hits	282	Target Neighborhood Hits	170	Shared Neighborhood Hits	112
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD1_HUMAN
NC score	0.888108 (rank : 9)	θ value	7.70199e-76 (rank : 8)
Query Neighborhood Hits	282	Target Neighborhood Hits	367	Shared Neighborhood Hits	131
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.886826 (rank : 10)	θ value	1.5519e-76 (rank : 7)
Query Neighborhood Hits	282	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
NC score	0.868323 (rank : 11)	θ value	2.57589e-55 (rank : 11)
Query Neighborhood Hits	282	Target Neighborhood Hits	249	Shared Neighborhood Hits	108
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.861954 (rank : 12)	θ value	2.84797e-54 (rank : 12)
Query Neighborhood Hits	282	Target Neighborhood Hits	257	Shared Neighborhood Hits	118
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PKHF1_HUMAN
NC score	0.718300 (rank : 13)	θ value	7.80994e-28 (rank : 16)
Query Neighborhood Hits	282	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF2_HUMAN
NC score	0.717929 (rank : 14)	θ value	8.08199e-25 (rank : 18)
Query Neighborhood Hits	282	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.717377 (rank : 15)	θ value	1.37858e-24 (rank : 19)
Query Neighborhood Hits	282	Target Neighborhood Hits	77	Shared Neighborhood Hits	63
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.715782 (rank : 16)	θ value	5.06226e-27 (rank : 17)
Query Neighborhood Hits	282	Target Neighborhood Hits	80	Shared Neighborhood Hits	60
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ECT2_MOUSE
NC score	0.652386 (rank : 17)	θ value	2.97466e-19 (rank : 20)
Query Neighborhood Hits	282	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.639011 (rank : 18)	θ value	8.65492e-19 (rank : 22)
Query Neighborhood Hits	282	Target Neighborhood Hits	98	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.635089 (rank : 19)	θ value	9.56915e-18 (rank : 24)
Query Neighborhood Hits	282	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.607021 (rank : 20)	θ value	6.20254e-17 (rank : 26)
Query Neighborhood Hits	282	Target Neighborhood Hits	174	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_HUMAN
NC score	0.574406 (rank : 21)	θ value	3.07829e-16 (rank : 29)
Query Neighborhood Hits	282	Target Neighborhood Hits	187	Shared Neighborhood Hits	69
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG5_HUMAN
NC score	0.572539 (rank : 22)	θ value	2.28291e-11 (rank : 38)
Query Neighborhood Hits	282	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_MOUSE
NC score	0.572513 (rank : 23)	θ value	1.80466e-16 (rank : 27)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_MOUSE
NC score	0.558066 (rank : 24)	θ value	1.79215e-40 (rank : 13)
Query Neighborhood Hits	282	Target Neighborhood Hits	209	Shared Neighborhood Hits	103
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ZFY28_HUMAN
NC score	0.557471 (rank : 25)	θ value	5.08577e-11 (rank : 41)
Query Neighborhood Hits	282	Target Neighborhood Hits	152	Shared Neighborhood Hits	53
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.553032 (rank : 26)	θ value	8.95645e-16 (rank : 33)
Query Neighborhood Hits	282	Target Neighborhood Hits	134	Shared Neighborhood Hits	51
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ARHGG_HUMAN
NC score	0.551310 (rank : 27)	θ value	1.38499e-08 (rank : 60)
Query Neighborhood Hits	282	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.550249 (rank : 28)	θ value	8.67504e-11 (rank : 42)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ZFY21_MOUSE
NC score	0.547954 (rank : 29)	θ value	2.79066e-09 (rank : 57)
Query Neighborhood Hits	282	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FARP2_HUMAN
NC score	0.546555 (rank : 30)	θ value	3.05695e-40 (rank : 14)
Query Neighborhood Hits	282	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG4_MOUSE
NC score	0.544230 (rank : 31)	θ value	5.62301e-10 (rank : 48)
Query Neighborhood Hits	282	Target Neighborhood Hits	185	Shared Neighborhood Hits	66
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ZFY16_MOUSE
NC score	0.544016 (rank : 32)	θ value	2.7842e-17 (rank : 25)
Query Neighborhood Hits	282	Target Neighborhood Hits	108	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.543191 (rank : 33)	θ value	2.79066e-09 (rank : 56)
Query Neighborhood Hits	282	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

NGEF_MOUSE
NC score	0.541732 (rank : 34)	θ value	5.08577e-11 (rank : 40)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_MOUSE
NC score	0.537418 (rank : 35)	θ value	1.80886e-08 (rank : 61)
Query Neighborhood Hits	282	Target Neighborhood Hits	152	Shared Neighborhood Hits	64
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG4_HUMAN
NC score	0.535100 (rank : 36)	θ value	5.08577e-11 (rank : 39)
Query Neighborhood Hits	282	Target Neighborhood Hits	242	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ZFY16_HUMAN
NC score	0.533390 (rank : 37)	θ value	5.25075e-16 (rank : 32)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

FARP1_HUMAN
NC score	0.521989 (rank : 38)	θ value	9.20422e-37 (rank : 15)
Query Neighborhood Hits	282	Target Neighborhood Hits	241	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGF_HUMAN
NC score	0.515636 (rank : 39)	θ value	6.87365e-08 (rank : 65)
Query Neighborhood Hits	282	Target Neighborhood Hits	214	Shared Neighborhood Hits	78
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG9_HUMAN
NC score	0.514669 (rank : 40)	θ value	1.17247e-07 (rank : 67)
Query Neighborhood Hits	282	Target Neighborhood Hits	235	Shared Neighborhood Hits	67
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.512377 (rank : 41)	θ value	4.45536e-07 (rank : 73)
Query Neighborhood Hits	282	Target Neighborhood Hits	234	Shared Neighborhood Hits	67
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

MCF2_HUMAN
NC score	0.505993 (rank : 42)	θ value	5.81887e-07 (rank : 75)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	72
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MCF2L_MOUSE
NC score	0.481788 (rank : 43)	θ value	5.26297e-08 (rank : 64)
Query Neighborhood Hits	282	Target Neighborhood Hits	255	Shared Neighborhood Hits	77
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TIAM1_HUMAN
NC score	0.478518 (rank : 44)	θ value	7.59969e-07 (rank : 77)
Query Neighborhood Hits	282	Target Neighborhood Hits	225	Shared Neighborhood Hits	82
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.475900 (rank : 45)	θ value	3.19293e-05 (rank : 87)
Query Neighborhood Hits	282	Target Neighborhood Hits	205	Shared Neighborhood Hits	82
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GNRP_MOUSE
NC score	0.463039 (rank : 46)	θ value	1.42992e-13 (rank : 34)
Query Neighborhood Hits	282	Target Neighborhood Hits	191	Shared Neighborhood Hits	81
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
NC score	0.462854 (rank : 47)	θ value	1.17247e-07 (rank : 68)
Query Neighborhood Hits	282	Target Neighborhood Hits	350	Shared Neighborhood Hits	89
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_MOUSE
NC score	0.457359 (rank : 48)	θ value	5.44631e-05 (rank : 89)
Query Neighborhood Hits	282	Target Neighborhood Hits	120	Shared Neighborhood Hits	60
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG1_HUMAN
NC score	0.456468 (rank : 49)	θ value	3.41135e-07 (rank : 72)
Query Neighborhood Hits	282	Target Neighborhood Hits	176	Shared Neighborhood Hits	60
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG8_HUMAN
NC score	0.440802 (rank : 50)	θ value	3.77169e-06 (rank : 81)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG1_MOUSE
NC score	0.438391 (rank : 51)	θ value	7.59969e-07 (rank : 76)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	59
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
NC score	0.438212 (rank : 52)	θ value	3.19293e-05 (rank : 86)
Query Neighborhood Hits	282	Target Neighborhood Hits	375	Shared Neighborhood Hits	75
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

GNRP_HUMAN
NC score	0.434903 (rank : 53)	θ value	1.2105e-12 (rank : 37)
Query Neighborhood Hits	282	Target Neighborhood Hits	239	Shared Neighborhood Hits	81
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

PKHG4_HUMAN
NC score	0.428271 (rank : 54)	θ value	0.00020696 (rank : 97)
Query Neighborhood Hits	282	Target Neighborhood Hits	200	Shared Neighborhood Hits	55
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

HGS_MOUSE
NC score	0.415794 (rank : 55)	θ value	2.36244e-08 (rank : 62)
Query Neighborhood Hits	282	Target Neighborhood Hits	589	Shared Neighborhood Hits	85
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.413919 (rank : 56)	θ value	6.87365e-08 (rank : 66)
Query Neighborhood Hits	282	Target Neighborhood Hits	517	Shared Neighborhood Hits	80
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

BCR_HUMAN
NC score	0.410662 (rank : 57)	θ value	5.25075e-16 (rank : 31)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ZFYV1_HUMAN
NC score	0.408743 (rank : 58)	θ value	6.43352e-06 (rank : 84)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

LBC_HUMAN
NC score	0.406785 (rank : 59)	θ value	0.000786445 (rank : 102)
Query Neighborhood Hits	282	Target Neighborhood Hits	90	Shared Neighborhood Hits	55
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGC_HUMAN
NC score	0.406340 (rank : 60)	θ value	7.1131e-05 (rank : 91)
Query Neighborhood Hits	282	Target Neighborhood Hits	351	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG3_HUMAN
NC score	0.405452 (rank : 61)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	282	Target Neighborhood Hits	82	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.405308 (rank : 62)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ZFYV1_MOUSE
NC score	0.403721 (rank : 63)	θ value	1.43324e-05 (rank : 85)
Query Neighborhood Hits	282	Target Neighborhood Hits	153	Shared Neighborhood Hits	51
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ABR_HUMAN
NC score	0.401997 (rank : 64)	θ value	1.133e-10 (rank : 43)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	66
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGC_MOUSE
NC score	0.401483 (rank : 65)	θ value	0.000602161 (rank : 99)
Query Neighborhood Hits	282	Target Neighborhood Hits	344	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

RBNS5_HUMAN
NC score	0.390169 (rank : 66)	θ value	7.1131e-05 (rank : 92)
Query Neighborhood Hits	282	Target Neighborhood Hits	242	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

ITSN2_HUMAN
NC score	0.384182 (rank : 67)	θ value	2.35696e-16 (rank : 28)
Query Neighborhood Hits	282	Target Neighborhood Hits	1173	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.381836 (rank : 68)	θ value	1.99992e-07 (rank : 71)
Query Neighborhood Hits	282	Target Neighborhood Hits	430	Shared Neighborhood Hits	73
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

RBNS5_MOUSE
NC score	0.381254 (rank : 69)	θ value	7.1131e-05 (rank : 93)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHG2_HUMAN
NC score	0.380091 (rank : 70)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	282	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG7_HUMAN
NC score	0.378368 (rank : 71)	θ value	4.1701e-05 (rank : 88)
Query Neighborhood Hits	282	Target Neighborhood Hits	347	Shared Neighborhood Hits	73
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_HUMAN
NC score	0.377361 (rank : 72)	θ value	7.59969e-07 (rank : 78)
Query Neighborhood Hits	282	Target Neighborhood Hits	452	Shared Neighborhood Hits	72
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG8_MOUSE
NC score	0.375104 (rank : 73)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	282	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ITSN2_MOUSE
NC score	0.368921 (rank : 74)	θ value	4.02038e-16 (rank : 30)
Query Neighborhood Hits	282	Target Neighborhood Hits	1371	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

FYV1_HUMAN
NC score	0.368536 (rank : 75)	θ value	1.06045e-08 (rank : 59)
Query Neighborhood Hits	282	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

VAV2_MOUSE
NC score	0.367626 (rank : 76)	θ value	4.92598e-06 (rank : 83)
Query Neighborhood Hits	282	Target Neighborhood Hits	456	Shared Neighborhood Hits	74
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.366865 (rank : 77)	θ value	9.59137e-10 (rank : 51)
Query Neighborhood Hits	282	Target Neighborhood Hits	404	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.365832 (rank : 78)	θ value	4.30538e-10 (rank : 47)
Query Neighborhood Hits	282	Target Neighborhood Hits	398	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

FYV1_MOUSE
NC score	0.365286 (rank : 79)	θ value	5.26297e-08 (rank : 63)
Query Neighborhood Hits	282	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY19_HUMAN
NC score	0.362882 (rank : 80)	θ value	7.1131e-05 (rank : 94)
Query Neighborhood Hits	282	Target Neighborhood Hits	206	Shared Neighborhood Hits	49
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

DNMBP_MOUSE
NC score	0.360741 (rank : 81)	θ value	0.0148317 (rank : 118)
Query Neighborhood Hits	282	Target Neighborhood Hits	435	Shared Neighborhood Hits	80
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_HUMAN
NC score	0.359234 (rank : 82)	θ value	9.29e-05 (rank : 95)
Query Neighborhood Hits	282	Target Neighborhood Hits	453	Shared Neighborhood Hits	73
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN1_MOUSE
NC score	0.358778 (rank : 83)	θ value	1.92812e-18 (rank : 23)
Query Neighborhood Hits	282	Target Neighborhood Hits	1669	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.358482 (rank : 84)	θ value	3.88503e-19 (rank : 21)
Query Neighborhood Hits	282	Target Neighborhood Hits	1757	Shared Neighborhood Hits	124
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG7_MOUSE
NC score	0.353714 (rank : 85)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	282	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ZFY19_MOUSE
NC score	0.346411 (rank : 86)	θ value	0.00665767 (rank : 117)
Query Neighborhood Hits	282	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

DNMBP_HUMAN
NC score	0.343493 (rank : 87)	θ value	0.00390308 (rank : 113)
Query Neighborhood Hits	282	Target Neighborhood Hits	413	Shared Neighborhood Hits	75
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RGNEF_MOUSE
NC score	0.335837 (rank : 88)	θ value	5.44631e-05 (rank : 90)
Query Neighborhood Hits	282	Target Neighborhood Hits	641	Shared Neighborhood Hits	81
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG6_HUMAN
NC score	0.319987 (rank : 89)	θ value	0.0736092 (rank : 130)
Query Neighborhood Hits	282	Target Neighborhood Hits	376	Shared Neighborhood Hits	63
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RUFY2_MOUSE
NC score	0.313670 (rank : 90)	θ value	1.9326e-10 (rank : 44)
Query Neighborhood Hits	282	Target Neighborhood Hits	820	Shared Neighborhood Hits	76
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.308756 (rank : 91)	θ value	9.59137e-10 (rank : 50)
Query Neighborhood Hits	282	Target Neighborhood Hits	765	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

MTMR3_HUMAN
NC score	0.307662 (rank : 92)	θ value	9.59137e-10 (rank : 49)
Query Neighborhood Hits	282	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY3_MOUSE
NC score	0.305231 (rank : 93)	θ value	2.13673e-09 (rank : 54)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	52
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.304957 (rank : 94)	θ value	2.13673e-09 (rank : 53)
Query Neighborhood Hits	282	Target Neighborhood Hits	348	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

RUFY1_HUMAN
NC score	0.304353 (rank : 95)	θ value	1.63604e-09 (rank : 52)
Query Neighborhood Hits	282	Target Neighborhood Hits	848	Shared Neighborhood Hits	76
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ARHG6_MOUSE
NC score	0.298920 (rank : 96)	θ value	0.00665767 (rank : 114)
Query Neighborhood Hits	282	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

WDFY1_HUMAN
NC score	0.298453 (rank : 97)	θ value	0.000158464 (rank : 96)
Query Neighborhood Hits	282	Target Neighborhood Hits	305	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
NC score	0.275756 (rank : 98)	θ value	0.00134147 (rank : 107)
Query Neighborhood Hits	282	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.273598 (rank : 99)	θ value	0.00134147 (rank : 106)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.259723 (rank : 100)	θ value	2.52405e-10 (rank : 45)
Query Neighborhood Hits	282	Target Neighborhood Hits	1208	Shared Neighborhood Hits	92
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PKHA6_HUMAN
NC score	0.257473 (rank : 101)	θ value	1.99992e-07 (rank : 70)
Query Neighborhood Hits	282	Target Neighborhood Hits	556	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.257175 (rank : 102)	θ value	1.17247e-07 (rank : 69)
Query Neighborhood Hits	282	Target Neighborhood Hits	591	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FYCO1_HUMAN
NC score	0.225467 (rank : 103)	θ value	3.29651e-10 (rank : 46)
Query Neighborhood Hits	282	Target Neighborhood Hits	1149	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ZFY27_MOUSE
NC score	0.223753 (rank : 104)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	282	Target Neighborhood Hits	53	Shared Neighborhood Hits	41
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.217934 (rank : 105)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	282	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

SOS1_HUMAN
NC score	0.217047 (rank : 106)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	282	Target Neighborhood Hits	274	Shared Neighborhood Hits	60
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

FYCO1_MOUSE
NC score	0.206627 (rank : 107)	θ value	4.45536e-07 (rank : 74)
Query Neighborhood Hits	282	Target Neighborhood Hits	1059	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

SOS2_HUMAN
NC score	0.206533 (rank : 108)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	282	Target Neighborhood Hits	193	Shared Neighborhood Hits	54
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

EEA1_MOUSE
NC score	0.205898 (rank : 109)	θ value	6.21693e-09 (rank : 58)
Query Neighborhood Hits	282	Target Neighborhood Hits	1637	Shared Neighborhood Hits	110
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SOS1_MOUSE
NC score	0.202411 (rank : 110)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	282	Target Neighborhood Hits	281	Shared Neighborhood Hits	61
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ANFY1_MOUSE
NC score	0.200299 (rank : 111)	θ value	1.29631e-06 (rank : 79)
Query Neighborhood Hits	282	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.199776 (rank : 112)	θ value	1.69304e-06 (rank : 80)
Query Neighborhood Hits	282	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

DUET_HUMAN
NC score	0.197610 (rank : 113)	θ value	1.2105e-12 (rank : 36)
Query Neighborhood Hits	282	Target Neighborhood Hits	1220	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

PKHA5_HUMAN
NC score	0.193944 (rank : 114)	θ value	0.00102713 (rank : 103)
Query Neighborhood Hits	282	Target Neighborhood Hits	455	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

EEA1_HUMAN
NC score	0.192502 (rank : 115)	θ value	2.79066e-09 (rank : 55)
Query Neighborhood Hits	282	Target Neighborhood Hits	1796	Shared Neighborhood Hits	111
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TRIO_HUMAN
NC score	0.190615 (rank : 116)	θ value	7.09661e-13 (rank : 35)
Query Neighborhood Hits	282	Target Neighborhood Hits	1580	Shared Neighborhood Hits	113
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHA4_MOUSE
NC score	0.180308 (rank : 117)	θ value	0.0330416 (rank : 122)
Query Neighborhood Hits	282	Target Neighborhood Hits	202	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
NC score	0.176357 (rank : 118)	θ value	0.0431538 (rank : 126)
Query Neighborhood Hits	282	Target Neighborhood Hits	283	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ALS2_MOUSE
NC score	0.157684 (rank : 119)	θ value	0.000270298 (rank : 98)
Query Neighborhood Hits	282	Target Neighborhood Hits	111	Shared Neighborhood Hits	25
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CNKR1_HUMAN
NC score	0.149435 (rank : 120)	θ value	0.0193708 (rank : 119)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

ALS2_HUMAN
NC score	0.142519 (rank : 121)	θ value	0.00228821 (rank : 108)
Query Neighborhood Hits	282	Target Neighborhood Hits	121	Shared Neighborhood Hits	28
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CNKR2_MOUSE
NC score	0.140224 (rank : 122)	θ value	0.00665767 (rank : 116)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	41
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.139761 (rank : 123)	θ value	0.00665767 (rank : 115)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SWP70_HUMAN
NC score	0.121661 (rank : 124)	θ value	0.0736092 (rank : 133)
Query Neighborhood Hits	282	Target Neighborhood Hits	973	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.118371 (rank : 125)	θ value	0.0431538 (rank : 127)
Query Neighborhood Hits	282	Target Neighborhood Hits	1097	Shared Neighborhood Hits	100
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA3_MOUSE
NC score	0.115052 (rank : 126)	θ value	0.00298849 (rank : 111)
Query Neighborhood Hits	282	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_HUMAN
NC score	0.114734 (rank : 127)	θ value	0.00134147 (rank : 105)
Query Neighborhood Hits	282	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

CYH3_MOUSE
NC score	0.106441 (rank : 128)	θ value	0.0563607 (rank : 128)
Query Neighborhood Hits	282	Target Neighborhood Hits	148	Shared Neighborhood Hits	58
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

OSBL9_HUMAN
NC score	0.101709 (rank : 129)	θ value	0.365318 (rank : 150)
Query Neighborhood Hits	282	Target Neighborhood Hits	138	Shared Neighborhood Hits	43
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PKHA2_MOUSE
NC score	0.101421 (rank : 130)	θ value	0.365318 (rank : 152)
Query Neighborhood Hits	282	Target Neighborhood Hits	116	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SH3K1_HUMAN
NC score	0.100486 (rank : 131)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	282	Target Neighborhood Hits	341	Shared Neighborhood Hits	40
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CYH4_MOUSE
NC score	0.100195 (rank : 132)	θ value	0.0252991 (rank : 120)
Query Neighborhood Hits	282	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

NCF1_HUMAN
NC score	0.100146 (rank : 133)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	282	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

C43BP_MOUSE
NC score	0.097721 (rank : 134)	θ value	0.279714 (rank : 140)
Query Neighborhood Hits	282	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_HUMAN
NC score	0.096411 (rank : 135)	θ value	0.279714 (rank : 139)
Query Neighborhood Hits	282	Target Neighborhood Hits	87	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

NCF1_MOUSE
NC score	0.094819 (rank : 136)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	282	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CYH4_HUMAN
NC score	0.094194 (rank : 137)	θ value	0.0431538 (rank : 124)
Query Neighborhood Hits	282	Target Neighborhood Hits	135	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

RUFY3_MOUSE
NC score	0.092255 (rank : 138)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	282	Target Neighborhood Hits	579	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

MTMRD_HUMAN
NC score	0.092019 (rank : 139)	θ value	0.000602161 (rank : 101)
Query Neighborhood Hits	282	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

RUFY3_HUMAN
NC score	0.091686 (rank : 140)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	282	Target Neighborhood Hits	594	Shared Neighborhood Hits	30
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

OBSCN_HUMAN
NC score	0.091684 (rank : 141)	θ value	4.92598e-06 (rank : 82)
Query Neighborhood Hits	282	Target Neighborhood Hits	1931	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SH3K1_MOUSE
NC score	0.091476 (rank : 142)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	282	Target Neighborhood Hits	332	Shared Neighborhood Hits	38
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.091453 (rank : 143)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	282	Target Neighborhood Hits	336	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.091426 (rank : 144)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	282	Target Neighborhood Hits	315	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CYH3_HUMAN
NC score	0.088839 (rank : 145)	θ value	0.365318 (rank : 147)
Query Neighborhood Hits	282	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

SRBS1_MOUSE
NC score	0.088824 (rank : 146)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	44
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.086056 (rank : 147)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	282	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PKHA2_HUMAN
NC score	0.085867 (rank : 148)	θ value	6.88961 (rank : 257)
Query Neighborhood Hits	282	Target Neighborhood Hits	119	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

CYH1_HUMAN
NC score	0.085074 (rank : 149)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	282	Target Neighborhood Hits	184	Shared Neighborhood Hits	62
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

NCF2_HUMAN
NC score	0.083869 (rank : 150)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	282	Target Neighborhood Hits	229	Shared Neighborhood Hits	26
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

PLEK_HUMAN
NC score	0.082711 (rank : 151)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	282	Target Neighborhood Hits	110	Shared Neighborhood Hits	48
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CYH1_MOUSE
NC score	0.082243 (rank : 152)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	282	Target Neighborhood Hits	176	Shared Neighborhood Hits	59
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

NCK1_HUMAN
NC score	0.081585 (rank : 153)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	30
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

VINEX_HUMAN
NC score	0.081124 (rank : 154)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	282	Target Neighborhood Hits	270	Shared Neighborhood Hits	34
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

MTMR5_HUMAN
NC score	0.080143 (rank : 155)	θ value	0.00298849 (rank : 110)
Query Neighborhood Hits	282	Target Neighborhood Hits	141	Shared Neighborhood Hits	30
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

VINEX_MOUSE
NC score	0.079815 (rank : 156)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	282	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK2_HUMAN
NC score	0.078937 (rank : 157)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	282	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

EXOC8_HUMAN
NC score	0.078421 (rank : 158)	θ value	0.000602161 (rank : 100)
Query Neighborhood Hits	282	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYI6, Q5TE82	Gene names	EXOC8
Domain Architecture	No domain graphic available
Description	Exocyst complex component 8 (Exocyst complex 84 kDa subunit).

CYH2_MOUSE
NC score	0.078409 (rank : 159)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	282	Target Neighborhood Hits	171	Shared Neighborhood Hits	56
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.078401 (rank : 160)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	282	Target Neighborhood Hits	175	Shared Neighborhood Hits	56
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

3BP2_HUMAN
NC score	0.077502 (rank : 161)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	282	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

STAM1_MOUSE
NC score	0.077061 (rank : 162)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	282	Target Neighborhood Hits	273	Shared Neighborhood Hits	29
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.076833 (rank : 163)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	282	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP_HUMAN
NC score	0.076446 (rank : 164)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PLEK_MOUSE
NC score	0.075901 (rank : 165)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	282	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

GRAP_MOUSE
NC score	0.075535 (rank : 166)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	282	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAM2_HUMAN
NC score	0.074189 (rank : 167)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	282	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
NC score	0.073959 (rank : 168)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	282	Target Neighborhood Hits	285	Shared Neighborhood Hits	28
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

3BP2_MOUSE
NC score	0.071863 (rank : 169)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	282	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

RFFL_MOUSE
NC score	0.071467 (rank : 170)	θ value	3.0926 (rank : 212)
Query Neighborhood Hits	282	Target Neighborhood Hits	145	Shared Neighborhood Hits	34
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

NCF4_HUMAN
NC score	0.070945 (rank : 171)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	282	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.070190 (rank : 172)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	282	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

REPS1_MOUSE
NC score	0.069788 (rank : 173)	θ value	0.163984 (rank : 138)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RHG25_MOUSE
NC score	0.068606 (rank : 174)	θ value	4.03905 (rank : 221)
Query Neighborhood Hits	282	Target Neighborhood Hits	492	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.068284 (rank : 175)	θ value	1.06291 (rank : 176)
Query Neighborhood Hits	282	Target Neighborhood Hits	550	Shared Neighborhood Hits	67
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RNF34_MOUSE
NC score	0.068140 (rank : 176)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	282	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

GRB2_HUMAN
NC score	0.067446 (rank : 177)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	282	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.067407 (rank : 178)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC_HUMAN
NC score	0.066118 (rank : 179)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	282	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI2_HUMAN
NC score	0.065397 (rank : 180)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	282	Target Neighborhood Hits	350	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

PKHA1_HUMAN
NC score	0.065079 (rank : 181)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	282	Target Neighborhood Hits	127	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

BI2L1_HUMAN
NC score	0.064955 (rank : 182)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	282	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

STAC_MOUSE
NC score	0.064408 (rank : 183)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	282	Target Neighborhood Hits	268	Shared Neighborhood Hits	24
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HCLS1_MOUSE
NC score	0.063688 (rank : 184)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	282	Target Neighborhood Hits	329	Shared Neighborhood Hits	34
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PKHA1_MOUSE
NC score	0.063645 (rank : 185)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	282	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ABI2_MOUSE
NC score	0.063591 (rank : 186)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	282	Target Neighborhood Hits	266	Shared Neighborhood Hits	32
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

TCGAP_MOUSE
NC score	0.063307 (rank : 187)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	46
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RNF34_HUMAN
NC score	0.063063 (rank : 188)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	282	Target Neighborhood Hits	153	Shared Neighborhood Hits	30
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

E41LB_HUMAN
NC score	0.063028 (rank : 189)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	282	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

PHLB2_MOUSE
NC score	0.062885 (rank : 190)	θ value	0.365318 (rank : 151)
Query Neighborhood Hits	282	Target Neighborhood Hits	1016	Shared Neighborhood Hits	74
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

STAC3_MOUSE
NC score	0.062760 (rank : 191)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	282	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SPTA2_HUMAN
NC score	0.062704 (rank : 192)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	282	Target Neighborhood Hits	888	Shared Neighborhood Hits	60
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DGKH_HUMAN
NC score	0.062569 (rank : 193)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	282	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

41_HUMAN
NC score	0.062454 (rank : 194)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	282	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L3_HUMAN
NC score	0.062436 (rank : 195)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	282	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

STAC3_HUMAN
NC score	0.062221 (rank : 196)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	22
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

E41L5_HUMAN
NC score	0.062104 (rank : 197)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	282	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

HCLS1_HUMAN
NC score	0.062089 (rank : 198)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	282	Target Neighborhood Hits	358	Shared Neighborhood Hits	33
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

E41L2_MOUSE
NC score	0.062059 (rank : 199)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	282	Target Neighborhood Hits	459	Shared Neighborhood Hits	27
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

GOGA3_MOUSE
NC score	0.061993 (rank : 200)	θ value	0.0961366 (rank : 134)
Query Neighborhood Hits	282	Target Neighborhood Hits	1437	Shared Neighborhood Hits	64
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

E41LB_MOUSE
NC score	0.061945 (rank : 201)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	282	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

PPIP1_HUMAN
NC score	0.061811 (rank : 202)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	282	Target Neighborhood Hits	389	Shared Neighborhood Hits	32
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.061737 (rank : 203)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	282	Target Neighborhood Hits	377	Shared Neighborhood Hits	37
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

41_MOUSE
NC score	0.061620 (rank : 204)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	282	Target Neighborhood Hits	184	Shared Neighborhood Hits	16
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

SRC8_HUMAN
NC score	0.061392 (rank : 205)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	282	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GRAP2_HUMAN
NC score	0.061148 (rank : 206)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	282	Target Neighborhood Hits	304	Shared Neighborhood Hits	25
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

E41L3_MOUSE
NC score	0.061109 (rank : 207)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	282	Target Neighborhood Hits	250	Shared Neighborhood Hits	12
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

ABI1_MOUSE
NC score	0.061077 (rank : 208)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	282	Target Neighborhood Hits	246	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

TCGAP_HUMAN
NC score	0.060838 (rank : 209)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	282	Target Neighborhood Hits	872	Shared Neighborhood Hits	57
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

GRAP2_MOUSE
NC score	0.060762 (rank : 210)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	282	Target Neighborhood Hits	297	Shared Neighborhood Hits	24
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

E41L1_HUMAN
NC score	0.060738 (rank : 211)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	282	Target Neighborhood Hits	180	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

FRMD5_MOUSE
NC score	0.060669 (rank : 212)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	282	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

EP15R_HUMAN
NC score	0.060642 (rank : 213)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	282	Target Neighborhood Hits	1083	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

RFFL_HUMAN
NC score	0.060556 (rank : 214)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	282	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

EP15R_MOUSE
NC score	0.060175 (rank : 215)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	282	Target Neighborhood Hits	1135	Shared Neighborhood Hits	55
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FRMD5_HUMAN
NC score	0.060128 (rank : 216)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	282	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

CRKL_HUMAN
NC score	0.059951 (rank : 217)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	282	Target Neighborhood Hits	313	Shared Neighborhood Hits	24
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SRC8_MOUSE
NC score	0.059901 (rank : 218)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	282	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

E41L1_MOUSE
NC score	0.059721 (rank : 219)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	282	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
NC score	0.059403 (rank : 220)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	282	Target Neighborhood Hits	287	Shared Neighborhood Hits	15
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

EP15_HUMAN
NC score	0.059238 (rank : 221)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	282	Target Neighborhood Hits	1021	Shared Neighborhood Hits	52
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MOES_MOUSE
NC score	0.059182 (rank : 222)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	282	Target Neighborhood Hits	923	Shared Neighborhood Hits	40
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MOES_HUMAN
NC score	0.058642 (rank : 223)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	282	Target Neighborhood Hits	892	Shared Neighborhood Hits	43
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

REPS2_HUMAN
NC score	0.058554 (rank : 224)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	282	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RADI_HUMAN
NC score	0.058532 (rank : 225)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	282	Target Neighborhood Hits	741	Shared Neighborhood Hits	41
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

ABI1_HUMAN
NC score	0.058492 (rank : 226)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	282	Target Neighborhood Hits	257	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CRKL_MOUSE
NC score	0.058294 (rank : 227)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	24
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PLCG1_MOUSE
NC score	0.058111 (rank : 228)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	28
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PHLB1_HUMAN
NC score	0.058022 (rank : 229)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	282	Target Neighborhood Hits	1038	Shared Neighborhood Hits	76
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SH3G2_HUMAN
NC score	0.057828 (rank : 230)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	282	Target Neighborhood Hits	324	Shared Neighborhood Hits	29
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

RADI_MOUSE
NC score	0.057593 (rank : 231)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	282	Target Neighborhood Hits	773	Shared Neighborhood Hits	40
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

PHLB2_HUMAN
NC score	0.057544 (rank : 232)	θ value	3.0926 (rank : 210)
Query Neighborhood Hits	282	Target Neighborhood Hits	964	Shared Neighborhood Hits	72
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

AHI1_HUMAN
NC score	0.057410 (rank : 233)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	282	Target Neighborhood Hits	537	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SH3G3_MOUSE
NC score	0.057274 (rank : 234)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	282	Target Neighborhood Hits	236	Shared Neighborhood Hits	22
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

IQEC3_HUMAN
NC score	0.057272 (rank : 235)	θ value	0.365318 (rank : 149)
Query Neighborhood Hits	282	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

E41LA_HUMAN
NC score	0.057140 (rank : 236)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	282	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

TARA_MOUSE
NC score	0.056804 (rank : 237)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	282	Target Neighborhood Hits	1133	Shared Neighborhood Hits	91
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

REPS2_MOUSE
NC score	0.056653 (rank : 238)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	282	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SHAN2_MOUSE
NC score	0.056610 (rank : 239)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	282	Target Neighborhood Hits	446	Shared Neighborhood Hits	52
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SH3G1_HUMAN
NC score	0.056574 (rank : 240)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	32
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SPTA1_HUMAN
NC score	0.056546 (rank : 241)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	282	Target Neighborhood Hits	748	Shared Neighborhood Hits	54
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PLCG1_HUMAN
NC score	0.056438 (rank : 242)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	282	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

EP15_MOUSE
NC score	0.056268 (rank : 243)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	282	Target Neighborhood Hits	820	Shared Neighborhood Hits	41
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

E41LA_MOUSE
NC score	0.055900 (rank : 244)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	282	Target Neighborhood Hits	85	Shared Neighborhood Hits	6
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

ABI3_HUMAN
NC score	0.055886 (rank : 245)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G3_HUMAN
NC score	0.055843 (rank : 246)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	282	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_MOUSE
NC score	0.055773 (rank : 247)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	282	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CRK_MOUSE
NC score	0.055578 (rank : 248)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEBL_HUMAN
NC score	0.055522 (rank : 249)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	282	Target Neighborhood Hits	457	Shared Neighborhood Hits	36
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SPTA1_MOUSE
NC score	0.055510 (rank : 250)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	282	Target Neighborhood Hits	675	Shared Neighborhood Hits	52
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RHG04_HUMAN
NC score	0.055475 (rank : 251)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	282	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PLEK2_MOUSE
NC score	0.055393 (rank : 252)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	282	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

ABI3_MOUSE
NC score	0.055360 (rank : 253)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	282	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PLEK2_HUMAN
NC score	0.055272 (rank : 254)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	282	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

CJ064_HUMAN
NC score	0.054963 (rank : 255)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	282	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

EZRI_MOUSE
NC score	0.054958 (rank : 256)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	282	Target Neighborhood Hits	693	Shared Neighborhood Hits	38
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

REPS1_HUMAN
NC score	0.054805 (rank : 257)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	282	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TARA_HUMAN
NC score	0.054720 (rank : 258)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	282	Target Neighborhood Hits	1626	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

EZRI_HUMAN
NC score	0.054416 (rank : 259)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	282	Target Neighborhood Hits	663	Shared Neighborhood Hits	37
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

BI2L1_MOUSE
NC score	0.054262 (rank : 260)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	282	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

MERL_MOUSE
NC score	0.054113 (rank : 261)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	282	Target Neighborhood Hits	524	Shared Neighborhood Hits	29
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

PRG4_HUMAN
NC score	0.054080 (rank : 262)	θ value	0.00102713 (rank : 104)
Query Neighborhood Hits	282	Target Neighborhood Hits	764	Shared Neighborhood Hits	55
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FNBP2_HUMAN
NC score	0.053894 (rank : 263)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	282	Target Neighborhood Hits	432	Shared Neighborhood Hits	42
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SH3G1_MOUSE
NC score	0.053803 (rank : 264)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	282	Target Neighborhood Hits	291	Shared Neighborhood Hits	26
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

MERL_HUMAN
NC score	0.053715 (rank : 265)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	282	Target Neighborhood Hits	532	Shared Neighborhood Hits	29
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

NOXO1_MOUSE
NC score	0.053168 (rank : 266)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	282	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

BSN_HUMAN
NC score	0.053113 (rank : 267)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	282	Target Neighborhood Hits	1537	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CRK_HUMAN
NC score	0.053092 (rank : 268)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	282	Target Neighborhood Hits	308	Shared Neighborhood Hits	26
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CEND1_HUMAN
NC score	0.052921 (rank : 269)	θ value	2.36792 (rank : 190)
Query Neighborhood Hits	282	Target Neighborhood Hits	284	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RIMB1_HUMAN
NC score	0.052911 (rank : 270)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	282	Target Neighborhood Hits	1479	Shared Neighborhood Hits	86
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MYLIP_MOUSE
NC score	0.052548 (rank : 271)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	282	Target Neighborhood Hits	139	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

TACC2_HUMAN
NC score	0.052311 (rank : 272)	θ value	0.0330416 (rank : 123)
Query Neighborhood Hits	282	Target Neighborhood Hits	856	Shared Neighborhood Hits	55
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

MYLIP_HUMAN
NC score	0.052254 (rank : 273)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	282	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

ZN318_HUMAN
NC score	0.052142 (rank : 274)	θ value	0.279714 (rank : 145)
Query Neighborhood Hits	282	Target Neighborhood Hits	497	Shared Neighborhood Hits	39
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

EFS_MOUSE
NC score	0.051971 (rank : 275)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	282	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CCD96_MOUSE
NC score	0.051886 (rank : 276)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	282	Target Neighborhood Hits	704	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

ASPP1_MOUSE
NC score	0.051862 (rank : 277)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	282	Target Neighborhood Hits	1244	Shared Neighborhood Hits	80
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SRGP1_HUMAN
NC score	0.051795 (rank : 278)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	282	Target Neighborhood Hits	390	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

DBNL_HUMAN
NC score	0.051706 (rank : 279)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	282	Target Neighborhood Hits	244	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

NOXO1_HUMAN
NC score	0.051670 (rank : 280)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	282	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

AHI1_MOUSE
NC score	0.051286 (rank : 281)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	282	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

BSN_MOUSE
NC score	0.051258 (rank : 282)	θ value	3.0926 (rank : 201)
Query Neighborhood Hits	282	Target Neighborhood Hits	2057	Shared Neighborhood Hits	100
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

IQEC3_MOUSE
NC score	0.051220 (rank : 283)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	282	Target Neighborhood Hits	274	Shared Neighborhood Hits	33
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

TACC2_MOUSE
NC score	0.051167 (rank : 284)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	282	Target Neighborhood Hits	774	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

PCLO_HUMAN
NC score	0.051144 (rank : 285)	θ value	0.163984 (rank : 137)
Query Neighborhood Hits	282	Target Neighborhood Hits	2046	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

OSTF1_HUMAN
NC score	0.050831 (rank : 286)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	282	Target Neighborhood Hits	466	Shared Neighborhood Hits	26
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

RFIP3_HUMAN
NC score	0.050290 (rank : 287)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	282	Target Neighborhood Hits	1055	Shared Neighborhood Hits	61
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

NPHP1_MOUSE
NC score	0.050284 (rank : 288)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	282	Target Neighborhood Hits	267	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_MOUSE
NC score	0.050236 (rank : 289)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	282	Target Neighborhood Hits	467	Shared Neighborhood Hits	26
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

NACAM_MOUSE
NC score	0.049670 (rank : 290)	θ value	0.0431538 (rank : 125)
Query Neighborhood Hits	282	Target Neighborhood Hits	1866	Shared Neighborhood Hits	87
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NUMA1_HUMAN
NC score	0.049601 (rank : 291)	θ value	0.62314 (rank : 159)
Query Neighborhood Hits	282	Target Neighborhood Hits	1523	Shared Neighborhood Hits	69
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

MAP4_MOUSE
NC score	0.048861 (rank : 292)	θ value	0.00298849 (rank : 109)
Query Neighborhood Hits	282	Target Neighborhood Hits	409	Shared Neighborhood Hits	30
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

CEND1_MOUSE
NC score	0.048819 (rank : 293)	θ value	1.06291 (rank : 172)
Query Neighborhood Hits	282	Target Neighborhood Hits	260	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

PHLB1_MOUSE
NC score	0.048110 (rank : 294)	θ value	4.03905 (rank : 219)
Query Neighborhood Hits	282	Target Neighborhood Hits	678	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PSD4_HUMAN
NC score	0.045913 (rank : 295)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	282	Target Neighborhood Hits	178	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SPTB2_HUMAN
NC score	0.045304 (rank : 296)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	282	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

OSB11_MOUSE
NC score	0.045115 (rank : 297)	θ value	0.47712 (rank : 156)
Query Neighborhood Hits	282	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

ZN318_MOUSE
NC score	0.044753 (rank : 298)	θ value	0.365318 (rank : 155)
Query Neighborhood Hits	282	Target Neighborhood Hits	642	Shared Neighborhood Hits	45
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

TAF4_HUMAN
NC score	0.044168 (rank : 299)	θ value	2.36792 (rank : 197)
Query Neighborhood Hits	282	Target Neighborhood Hits	687	Shared Neighborhood Hits	41
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SPTB2_MOUSE
NC score	0.043906 (rank : 300)	θ value	1.81305 (rank : 189)
Query Neighborhood Hits	282	Target Neighborhood Hits	770	Shared Neighborhood Hits	58
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

OSBP1_HUMAN
NC score	0.042932 (rank : 301)	θ value	3.0926 (rank : 207)
Query Neighborhood Hits	282	Target Neighborhood Hits	180	Shared Neighborhood Hits	41
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

AFF1_HUMAN
NC score	0.042007 (rank : 302)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	282	Target Neighborhood Hits	506	Shared Neighborhood Hits	37
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

MDC1_HUMAN
NC score	0.040492 (rank : 303)	θ value	1.06291 (rank : 175)
Query Neighborhood Hits	282	Target Neighborhood Hits	1446	Shared Neighborhood Hits	76
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

FSTL1_MOUSE
NC score	0.040379 (rank : 304)	θ value	0.279714 (rank : 142)
Query Neighborhood Hits	282	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

SRRM1_MOUSE
NC score	0.039967 (rank : 305)	θ value	0.279714 (rank : 144)
Query Neighborhood Hits	282	Target Neighborhood Hits	966	Shared Neighborhood Hits	54
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TARSH_HUMAN
NC score	0.039723 (rank : 306)	θ value	2.36792 (rank : 198)
Query Neighborhood Hits	282	Target Neighborhood Hits	768	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

FSTL1_HUMAN
NC score	0.039379 (rank : 307)	θ value	0.365318 (rank : 148)
Query Neighborhood Hits	282	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

MAP9_MOUSE
NC score	0.039118 (rank : 308)	θ value	0.279714 (rank : 143)
Query Neighborhood Hits	282	Target Neighborhood Hits	529	Shared Neighborhood Hits	36
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

WDR67_MOUSE
NC score	0.039106 (rank : 309)	θ value	0.0563607 (rank : 129)
Query Neighborhood Hits	282	Target Neighborhood Hits	476	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

TCOF_HUMAN
NC score	0.038529 (rank : 310)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	282	Target Neighborhood Hits	543	Shared Neighborhood Hits	45
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

SPTN4_HUMAN
NC score	0.037417 (rank : 311)	θ value	2.36792 (rank : 196)
Query Neighborhood Hits	282	Target Neighborhood Hits	570	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

PRG4_MOUSE
NC score	0.036116 (rank : 312)	θ value	3.0926 (rank : 211)
Query Neighborhood Hits	282	Target Neighborhood Hits	624	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RRBP1_MOUSE
NC score	0.035097 (rank : 313)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	282	Target Neighborhood Hits	1650	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CDR2_HUMAN
NC score	0.034953 (rank : 314)	θ value	4.03905 (rank : 216)
Query Neighborhood Hits	282	Target Neighborhood Hits	404	Shared Neighborhood Hits	30
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

ENL_HUMAN
NC score	0.033518 (rank : 315)	θ value	0.279714 (rank : 141)
Query Neighborhood Hits	282	Target Neighborhood Hits	305	Shared Neighborhood Hits	25
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

TAB2_HUMAN
NC score	0.033355 (rank : 316)	θ value	0.47712 (rank : 157)
Query Neighborhood Hits	282	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NYJ8, O94838, Q6I9W8, Q76N06, Q9UFP7	Gene names	MAP3K7IP2, KIAA0733, TAB2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2).

TAB2_MOUSE
NC score	0.032453 (rank : 317)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	282	Target Neighborhood Hits	245	Shared Neighborhood Hits	19
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

NFH_MOUSE
NC score	0.031057 (rank : 318)	θ value	0.0736092 (rank : 132)
Query Neighborhood Hits	282	Target Neighborhood Hits	2247	Shared Neighborhood Hits	107
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CENB1_HUMAN
NC score	0.030635 (rank : 319)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	282	Target Neighborhood Hits	383	Shared Neighborhood Hits	38
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

RASA3_MOUSE
NC score	0.030591 (rank : 320)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	282	Target Neighborhood Hits	144	Shared Neighborhood Hits	27
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

CTRO_MOUSE
NC score	0.030448 (rank : 321)	θ value	0.0736092 (rank : 131)
Query Neighborhood Hits	282	Target Neighborhood Hits	2344	Shared Neighborhood Hits	89
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

TNR25_HUMAN
NC score	0.030431 (rank : 322)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	282	Target Neighborhood Hits	172	Shared Neighborhood Hits	5
SwissProt Accessions	Q93038, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q92983, Q93036, Q93037, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5	Gene names	TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 25 precursor (WSL-1 protein) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death domain receptor 3) (WSL protein) (Apoptosis- inducing receptor AIR) (Apo-3) (Lymphocyte-associated receptor of death) (LARD).

SON_HUMAN
NC score	0.030309 (rank : 323)	θ value	1.06291 (rank : 177)
Query Neighborhood Hits	282	Target Neighborhood Hits	1568	Shared Neighborhood Hits	76
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

RASA3_HUMAN
NC score	0.030275 (rank : 324)	θ value	5.27518 (rank : 237)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

K1802_MOUSE
NC score	0.029223 (rank : 325)	θ value	1.06291 (rank : 173)
Query Neighborhood Hits	282	Target Neighborhood Hits	1596	Shared Neighborhood Hits	73
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

AFF1_MOUSE
NC score	0.029123 (rank : 326)	θ value	5.27518 (rank : 225)
Query Neighborhood Hits	282	Target Neighborhood Hits	351	Shared Neighborhood Hits	37
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

NRIP1_HUMAN
NC score	0.028891 (rank : 327)	θ value	0.0961366 (rank : 135)
Query Neighborhood Hits	282	Target Neighborhood Hits	88	Shared Neighborhood Hits	9
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

MAP1B_HUMAN
NC score	0.028309 (rank : 328)	θ value	5.27518 (rank : 234)
Query Neighborhood Hits	282	Target Neighborhood Hits	903	Shared Neighborhood Hits	53
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MYH10_MOUSE
NC score	0.028266 (rank : 329)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	282	Target Neighborhood Hits	1612	Shared Neighborhood Hits	67
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.028172 (rank : 330)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	282	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

K1683_HUMAN
NC score	0.026943 (rank : 331)	θ value	2.36792 (rank : 194)
Query Neighborhood Hits	282	Target Neighborhood Hits	240	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

K2002_MOUSE
NC score	0.026322 (rank : 332)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	282	Target Neighborhood Hits	267	Shared Neighborhood Hits	11
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MILK1_HUMAN
NC score	0.026016 (rank : 333)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	282	Target Neighborhood Hits	427	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

FACD2_HUMAN
NC score	0.025354 (rank : 334)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	282	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXW9, Q2LA86, Q69YP9, Q6PJN7, Q9BQ06, Q9H9T9	Gene names	FANCD2
Domain Architecture	No domain graphic available
Description	Fanconi anemia group D2 protein (Protein FACD2).

ANK2_HUMAN
NC score	0.024812 (rank : 335)	θ value	0.365318 (rank : 146)
Query Neighborhood Hits	282	Target Neighborhood Hits	1615	Shared Neighborhood Hits	78
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CTRO_HUMAN
NC score	0.024776 (rank : 336)	θ value	5.27518 (rank : 228)
Query Neighborhood Hits	282	Target Neighborhood Hits	2092	Shared Neighborhood Hits	82
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

K1543_HUMAN
NC score	0.024195 (rank : 337)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	282	Target Neighborhood Hits	435	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NFH_HUMAN
NC score	0.023446 (rank : 338)	θ value	1.81305 (rank : 187)
Query Neighborhood Hits	282	Target Neighborhood Hits	1242	Shared Neighborhood Hits	72
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

FYB_HUMAN
NC score	0.022401 (rank : 339)	θ value	5.27518 (rank : 230)
Query Neighborhood Hits	282	Target Neighborhood Hits	379	Shared Neighborhood Hits	31
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

TRI66_MOUSE
NC score	0.022126 (rank : 340)	θ value	3.0926 (rank : 213)
Query Neighborhood Hits	282	Target Neighborhood Hits	491	Shared Neighborhood Hits	28
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TRI66_HUMAN
NC score	0.021691 (rank : 341)	θ value	0.125558 (rank : 136)
Query Neighborhood Hits	282	Target Neighborhood Hits	479	Shared Neighborhood Hits	24
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

MAGE1_HUMAN
NC score	0.021672 (rank : 342)	θ value	5.27518 (rank : 233)
Query Neighborhood Hits	282	Target Neighborhood Hits	1389	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

GCP6_HUMAN
NC score	0.021644 (rank : 343)	θ value	5.27518 (rank : 231)
Query Neighborhood Hits	282	Target Neighborhood Hits	295	Shared Neighborhood Hits	22
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

SHAN2_HUMAN
NC score	0.021326 (rank : 344)	θ value	5.27518 (rank : 241)
Query Neighborhood Hits	282	Target Neighborhood Hits	346	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SH2D3_HUMAN
NC score	0.021216 (rank : 345)	θ value	0.62314 (rank : 161)
Query Neighborhood Hits	282	Target Neighborhood Hits	188	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

BAG3_HUMAN
NC score	0.021037 (rank : 346)	θ value	1.81305 (rank : 186)
Query Neighborhood Hits	282	Target Neighborhood Hits	314	Shared Neighborhood Hits	28
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

CAPS2_MOUSE
NC score	0.020410 (rank : 347)	θ value	1.38821 (rank : 180)
Query Neighborhood Hits	282	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYR5, O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8K3K6	Gene names	Cadps2, Caps2
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

IWS1_HUMAN
NC score	0.020124 (rank : 348)	θ value	5.27518 (rank : 232)
Query Neighborhood Hits	282	Target Neighborhood Hits	1241	Shared Neighborhood Hits	64
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SEPN1_HUMAN
NC score	0.019775 (rank : 349)	θ value	2.36792 (rank : 195)
Query Neighborhood Hits	282	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZV5, Q6PI70, Q969F6, Q9NUI6	Gene names	SEPN1, SELN
Domain Architecture	No domain graphic available
Description	Selenoprotein N precursor.

RFTN1_MOUSE
NC score	0.019573 (rank : 350)	θ value	0.62314 (rank : 160)
Query Neighborhood Hits	282	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A0D4, Q3U654, Q3U8P6, Q80US1	Gene names	Rftn1, Kiaa0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein).

PRR8_HUMAN
NC score	0.019234 (rank : 351)	θ value	6.88961 (rank : 258)
Query Neighborhood Hits	282	Target Neighborhood Hits	217	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

GRB7_MOUSE
NC score	0.019205 (rank : 352)	θ value	2.36792 (rank : 193)
Query Neighborhood Hits	282	Target Neighborhood Hits	157	Shared Neighborhood Hits	14
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

MUC1_HUMAN
NC score	0.018883 (rank : 353)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	282	Target Neighborhood Hits	975	Shared Neighborhood Hits	49
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

M3K11_HUMAN
NC score	0.018618 (rank : 354)	θ value	0.62314 (rank : 158)
Query Neighborhood Hits	282	Target Neighborhood Hits	1136	Shared Neighborhood Hits	49
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

GRB7_HUMAN
NC score	0.018203 (rank : 355)	θ value	6.88961 (rank : 249)
Query Neighborhood Hits	282	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

ZC3H6_HUMAN
NC score	0.017777 (rank : 356)	θ value	1.06291 (rank : 178)
Query Neighborhood Hits	282	Target Neighborhood Hits	228	Shared Neighborhood Hits	19
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

SYTL2_MOUSE
NC score	0.016611 (rank : 357)	θ value	0.62314 (rank : 162)
Query Neighborhood Hits	282	Target Neighborhood Hits	253	Shared Neighborhood Hits	16
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

MLL3_MOUSE
NC score	0.016214 (rank : 358)	θ value	6.88961 (rank : 252)
Query Neighborhood Hits	282	Target Neighborhood Hits	1399	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

REXO1_MOUSE
NC score	0.016199 (rank : 359)	θ value	4.03905 (rank : 220)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

B2L13_HUMAN
NC score	0.016178 (rank : 360)	θ value	5.27518 (rank : 226)
Query Neighborhood Hits	282	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BXK5, Q96B37, Q96IB7, Q9BY01, Q9HC05, Q9UFE0, Q9UKN3	Gene names	BCL2L13, MIL1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

CAPS2_HUMAN
NC score	0.016150 (rank : 361)	θ value	5.27518 (rank : 227)
Query Neighborhood Hits	282	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

RTN4_MOUSE
NC score	0.015934 (rank : 362)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	282	Target Neighborhood Hits	341	Shared Neighborhood Hits	34
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

2AAB_HUMAN
NC score	0.015838 (rank : 363)	θ value	1.38821 (rank : 179)
Query Neighborhood Hits	282	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

TM108_HUMAN
NC score	0.015838 (rank : 364)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	282	Target Neighborhood Hits	166	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

MCM4_HUMAN
NC score	0.015162 (rank : 365)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	282	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	P33991, Q8NEH1, Q99658	Gene names	MCM4, CDC21
Domain Architecture
Description	DNA replication licensing factor MCM4 (CDC21 homolog) (P1-CDC21).

CJ006_HUMAN
NC score	0.015074 (rank : 366)	θ value	2.36792 (rank : 191)
Query Neighborhood Hits	282	Target Neighborhood Hits	122	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

RC3H1_MOUSE
NC score	0.014804 (rank : 367)	θ value	5.27518 (rank : 239)
Query Neighborhood Hits	282	Target Neighborhood Hits	244	Shared Neighborhood Hits	15
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

DPOD3_MOUSE
NC score	0.014803 (rank : 368)	θ value	5.27518 (rank : 229)
Query Neighborhood Hits	282	Target Neighborhood Hits	118	Shared Neighborhood Hits	16
SwissProt Accessions	Q9EQ28	Gene names	Pold3
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

K0319_HUMAN
NC score	0.014793 (rank : 369)	θ value	3.0926 (rank : 204)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	13
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

RC3H1_HUMAN
NC score	0.014004 (rank : 370)	θ value	5.27518 (rank : 238)
Query Neighborhood Hits	282	Target Neighborhood Hits	433	Shared Neighborhood Hits	18
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

ATRX_HUMAN
NC score	0.013982 (rank : 371)	θ value	4.03905 (rank : 215)
Query Neighborhood Hits	282	Target Neighborhood Hits	842	Shared Neighborhood Hits	45
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

REEP2_MOUSE
NC score	0.013518 (rank : 372)	θ value	5.27518 (rank : 240)
Query Neighborhood Hits	282	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCD6	Gene names	Reep2
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 2.

BCAS1_MOUSE
NC score	0.013430 (rank : 373)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	282	Target Neighborhood Hits	215	Shared Neighborhood Hits	17
SwissProt Accessions	Q80YN3, Q9CVA1	Gene names	Bcas1, Nabc1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 homolog (Novel amplified in breast cancer 1 homolog).

TF2AY_MOUSE
NC score	0.012863 (rank : 374)	θ value	2.36792 (rank : 199)
Query Neighborhood Hits	282	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

NOG2_HUMAN
NC score	0.012805 (rank : 375)	θ value	6.88961 (rank : 254)
Query Neighborhood Hits	282	Target Neighborhood Hits	117	Shared Neighborhood Hits	11
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

B2L13_MOUSE
NC score	0.012767 (rank : 376)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	282	Target Neighborhood Hits	58	Shared Neighborhood Hits	6
SwissProt Accessions	P59017	Gene names	Bcl2l13, Mil1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

YTHD2_HUMAN
NC score	0.011522 (rank : 377)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	282	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

TERT_HUMAN
NC score	0.010497 (rank : 378)	θ value	4.03905 (rank : 222)
Query Neighborhood Hits	282	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	O14746, O14783, Q2XS35, Q8N6C3	Gene names	TERT, EST2, TCS1, TRT
Domain Architecture	No domain graphic available
Description	Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalytic subunit) (HEST2) (Telomerase-associated protein 2) (TP2).

RAD52_MOUSE
NC score	0.010486 (rank : 379)	θ value	5.27518 (rank : 236)
Query Neighborhood Hits	282	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P43352	Gene names	Rad52
Domain Architecture
Description	DNA repair protein RAD52 homolog.

ZCHC6_MOUSE
NC score	0.010046 (rank : 380)	θ value	2.36792 (rank : 200)
Query Neighborhood Hits	282	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q5BLK4, Q8CIH3	Gene names	Zcchc6
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

AL2SA_HUMAN
NC score	0.009830 (rank : 381)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	282	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q53TS8, Q8NCN6, Q96LN4	Gene names	ALS2CR11
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein.

MBD4_MOUSE
NC score	0.009513 (rank : 382)	θ value	6.88961 (rank : 251)
Query Neighborhood Hits	282	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2D7, Q792D2, Q8R3R3	Gene names	Mbd4
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase).

NOG2_MOUSE
NC score	0.009471 (rank : 383)	θ value	6.88961 (rank : 255)
Query Neighborhood Hits	282	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

ETV3_HUMAN
NC score	0.008654 (rank : 384)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	282	Target Neighborhood Hits	312	Shared Neighborhood Hits	24
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

MINK1_HUMAN
NC score	0.008589 (rank : 385)	θ value	3.0926 (rank : 206)
Query Neighborhood Hits	282	Target Neighborhood Hits	1477	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

ITK_HUMAN
NC score	0.008584 (rank : 386)	θ value	3.0926 (rank : 203)
Query Neighborhood Hits	282	Target Neighborhood Hits	1016	Shared Neighborhood Hits	47
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CAMKV_HUMAN
NC score	0.008453 (rank : 387)	θ value	1.06291 (rank : 171)
Query Neighborhood Hits	282	Target Neighborhood Hits	1084	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

USP9X_HUMAN
NC score	0.008184 (rank : 388)	θ value	4.03905 (rank : 223)
Query Neighborhood Hits	282	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
NC score	0.008126 (rank : 389)	θ value	4.03905 (rank : 224)
Query Neighborhood Hits	282	Target Neighborhood Hits	171	Shared Neighborhood Hits	4
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

CD5R2_HUMAN
NC score	0.007973 (rank : 390)	θ value	6.88961 (rank : 246)
Query Neighborhood Hits	282	Target Neighborhood Hits	53	Shared Neighborhood Hits	9
SwissProt Accessions	Q13319, Q4ZFW6	Gene names	CDK5R2, NCK5AI
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 2 precursor (CDK5 activator 2) (Cyclin-dependent kinase 5 regulatory subunit 2) (P39) (P39I).

SC24C_HUMAN
NC score	0.007972 (rank : 391)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	282	Target Neighborhood Hits	662	Shared Neighborhood Hits	32
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

PDE2A_MOUSE
NC score	0.007878 (rank : 392)	θ value	3.0926 (rank : 209)
Query Neighborhood Hits	282	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

ETV3_MOUSE
NC score	0.007846 (rank : 393)	θ value	3.0926 (rank : 202)
Query Neighborhood Hits	282	Target Neighborhood Hits	128	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4Z4, Q9QZW1	Gene names	Etv3, Mets, Pe1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

EXDL2_MOUSE
NC score	0.007771 (rank : 394)	θ value	6.88961 (rank : 248)
Query Neighborhood Hits	282	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

UBE4A_HUMAN
NC score	0.007320 (rank : 395)	θ value	8.99809 (rank : 282)
Query Neighborhood Hits	282	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q14139, Q6P5T4, Q7Z639	Gene names	UBE4A, KIAA0126
Domain Architecture	No domain graphic available
Description	Ubiquitin conjugation factor E4 A.

CA156_HUMAN
NC score	0.006963 (rank : 396)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	282	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O95568	Gene names	C1orf156, ASTP2
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf156 (Arsenic-transactivated protein 2) (AsTP2).

DCC_MOUSE
NC score	0.006630 (rank : 397)	θ value	4.03905 (rank : 217)
Query Neighborhood Hits	282	Target Neighborhood Hits	896	Shared Neighborhood Hits	25
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

PO6F2_HUMAN
NC score	0.006537 (rank : 398)	θ value	1.81305 (rank : 188)
Query Neighborhood Hits	282	Target Neighborhood Hits	618	Shared Neighborhood Hits	27
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

EST1A_MOUSE
NC score	0.006107 (rank : 399)	θ value	6.88961 (rank : 247)
Query Neighborhood Hits	282	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	P61406, Q5NC64	Gene names	Est1a, Kiaa0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A).

PHAR3_MOUSE
NC score	0.006105 (rank : 400)	θ value	6.88961 (rank : 256)
Query Neighborhood Hits	282	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

TF3C2_HUMAN
NC score	0.005479 (rank : 401)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	282	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

MAST2_MOUSE
NC score	0.005464 (rank : 402)	θ value	4.03905 (rank : 218)
Query Neighborhood Hits	282	Target Neighborhood Hits	1110	Shared Neighborhood Hits	33
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

AXUD1_MOUSE
NC score	0.005455 (rank : 403)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	282	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P59054	Gene names	Axud1, Taip3
Domain Architecture	No domain graphic available
Description	Axin-1 up-regulated gene 1 protein (TGF-beta-induced apoptosis protein 3) (TAIP-3).

NKTR_HUMAN
NC score	0.005272 (rank : 404)	θ value	6.88961 (rank : 253)
Query Neighborhood Hits	282	Target Neighborhood Hits	658	Shared Neighborhood Hits	24
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

MAST2_HUMAN
NC score	0.005252 (rank : 405)	θ value	6.88961 (rank : 250)
Query Neighborhood Hits	282	Target Neighborhood Hits	1189	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MARK4_MOUSE
NC score	0.005099 (rank : 406)	θ value	0.0330416 (rank : 121)
Query Neighborhood Hits	282	Target Neighborhood Hits	898	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

DAF1_MOUSE
NC score	0.004325 (rank : 407)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	282	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

FOXN4_MOUSE
NC score	0.004084 (rank : 408)	θ value	2.36792 (rank : 192)
Query Neighborhood Hits	282	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Q3, Q920C0	Gene names	Foxn4
Domain Architecture
Description	Forkhead box protein N4.

KS6B2_MOUSE
NC score	0.002392 (rank : 409)	θ value	3.0926 (rank : 205)
Query Neighborhood Hits	282	Target Neighborhood Hits	871	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

CAC1D_HUMAN
NC score	0.000898 (rank : 410)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	282	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

PCD15_HUMAN
NC score	0.000721 (rank : 411)	θ value	3.0926 (rank : 208)
Query Neighborhood Hits	282	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

THAS_MOUSE
NC score	-0.001323 (rank : 412)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	282	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	P36423, P97505	Gene names	Tbxas1, Cyp5, Cyp5a1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (TS) (Cytochrome P450 5A1).

ZEP2_HUMAN
NC score	-0.001634 (rank : 413)	θ value	3.0926 (rank : 214)
Query Neighborhood Hits	282	Target Neighborhood Hits	937	Shared Neighborhood Hits	25
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ATS20_HUMAN
NC score	-0.001657 (rank : 414)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	282	Target Neighborhood Hits	192	Shared Neighborhood Hits	3
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

PCDB7_HUMAN
NC score	-0.002006 (rank : 415)	θ value	5.27518 (rank : 235)
Query Neighborhood Hits	282	Target Neighborhood Hits	149	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5E2	Gene names	PCDHB7
Domain Architecture
Description	Protocadherin beta 7 precursor (PCDH-beta7).

NKX61_HUMAN
NC score	-0.002176 (rank : 416)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	282	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	P78426	Gene names	NKX6-1, NKX6A
Domain Architecture
Description	Homeobox protein Nkx-6.1.

STAB1_HUMAN
NC score	-0.003181 (rank : 417)	θ value	6.88961 (rank : 259)
Query Neighborhood Hits	282	Target Neighborhood Hits	546	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NY15, Q8IUH0, Q8IUH1, Q93072	Gene names	STAB1, FEEL1, KIAA0246
Domain Architecture
Description	Stabilin-1 precursor (FEEL-1 protein) (MS-1 antigen).

EGR4_HUMAN
NC score	-0.005681 (rank : 418)	θ value	1.38821 (rank : 181)
Query Neighborhood Hits	282	Target Neighborhood Hits	939	Shared Neighborhood Hits	17
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

ZN690_HUMAN
NC score	-0.007116 (rank : 419)	θ value	5.27518 (rank : 242)
Query Neighborhood Hits	282	Target Neighborhood Hits	777	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWY8, Q32M75, Q32M76, Q8NA40	Gene names	ZNF690
Domain Architecture	No domain graphic available
Description	Zinc finger protein 690.

ZBT26_HUMAN
NC score	-0.007543 (rank : 420)	θ value	6.88961 (rank : 260)
Query Neighborhood Hits	282	Target Neighborhood Hits	784	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HCK0, Q8WTR1	Gene names	ZBTB26, KIAA1572, ZNF481
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 26 (Zinc finger protein 481) (Zinc finger protein Bioref).