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Network neighborhood for query Sequence : EXDL2_MOUSE

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EXDL2_MOUSE
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EXDL2_HUMAN
θ value	0 (rank : 1)	NC score	0.996734 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVH0, Q8N3D3	Gene names	EXDL2, C14orf114
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

EXDL2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

WRN_HUMAN
θ value	3.64472e-09 (rank : 3)	NC score	0.250269 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

WRN_MOUSE
θ value	1.53129e-07 (rank : 4)	NC score	0.237441 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

TTC28_HUMAN
θ value	4.03905 (rank : 5)	NC score	0.028658 (rank : 13)
Query Neighborhood Hits	11	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_MOUSE
θ value	4.03905 (rank : 6)	NC score	0.029410 (rank : 12)
Query Neighborhood Hits	11	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ZKSC1_MOUSE
θ value	4.03905 (rank : 7)	NC score	0.003869 (rank : 18)
Query Neighborhood Hits	11	Target Neighborhood Hits	755	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.

ANXA6_MOUSE
θ value	5.27518 (rank : 8)	NC score	0.009382 (rank : 14)
Query Neighborhood Hits	11	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P14824	Gene names	Anxa6, Anx6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

FGD6_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.007771 (rank : 16)
Query Neighborhood Hits	11	Target Neighborhood Hits	282	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FOLH1_HUMAN
θ value	8.99809 (rank : 10)	NC score	0.008499 (rank : 15)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

NAF1_MOUSE
θ value	8.99809 (rank : 11)	NC score	0.005796 (rank : 17)
Query Neighborhood Hits	11	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

BLM_HUMAN
θ value	θ > 10 (rank : 12)	NC score	0.060337 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	θ > 10 (rank : 13)	NC score	0.061047 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

RECQ1_HUMAN
θ value	θ > 10 (rank : 14)	NC score	0.070633 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	θ > 10 (rank : 15)	NC score	0.071116 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ4_HUMAN
θ value	θ > 10 (rank : 16)	NC score	0.056541 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
θ value	θ > 10 (rank : 17)	NC score	0.054383 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ5_HUMAN
θ value	θ > 10 (rank : 18)	NC score	0.065849 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	390	Shared Neighborhood Hits	2
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

Hits sorted by NC score

EXDL2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

EXDL2_HUMAN
NC score	0.996734 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	12	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NVH0, Q8N3D3	Gene names	EXDL2, C14orf114
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

WRN_HUMAN
NC score	0.250269 (rank : 3)	θ value	3.64472e-09 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	132	Shared Neighborhood Hits	4
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

WRN_MOUSE
NC score	0.237441 (rank : 4)	θ value	1.53129e-07 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ1_MOUSE
NC score	0.071116 (rank : 5)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	11	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_HUMAN
NC score	0.070633 (rank : 6)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	11	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ5_HUMAN
NC score	0.065849 (rank : 7)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	11	Target Neighborhood Hits	390	Shared Neighborhood Hits	2
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

BLM_MOUSE
NC score	0.061047 (rank : 8)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	11	Target Neighborhood Hits	108	Shared Neighborhood Hits	2
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.060337 (rank : 9)	θ value	θ > 10 (rank : 12)
Query Neighborhood Hits	11	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RECQ4_HUMAN
NC score	0.056541 (rank : 10)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	11	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.054383 (rank : 11)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	11	Target Neighborhood Hits	206	Shared Neighborhood Hits	2
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

TTC28_MOUSE
NC score	0.029410 (rank : 12)	θ value	4.03905 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TTC28_HUMAN
NC score	0.028658 (rank : 13)	θ value	4.03905 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ANXA6_MOUSE
NC score	0.009382 (rank : 14)	θ value	5.27518 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P14824	Gene names	Anxa6, Anx6
Domain Architecture
Description	Annexin A6 (Annexin VI) (Lipocortin VI) (P68) (P70) (Protein III) (Chromobindin-20) (67 kDa calelectrin) (Calphobindin-II) (CPB-II).

FOLH1_HUMAN
NC score	0.008499 (rank : 15)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q04609, O43748, Q16305, Q9NP15, Q9NYE2, Q9P1P8	Gene names	FOLH1, FOLH, NAALAD1, PSM, PSMA
Domain Architecture
Description	Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Glutamate carboxypeptidase II) (Membrane glutamate carboxypeptidase) (mGCP) (N- acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Pteroylpoly-gamma-glutamate carboxypeptidase) (Folylpoly-gamma- glutamate carboxypeptidase) (FGCP) (Folate hydrolase 1) (Prostate- specific membrane antigen) (PSMA) (PSM).

FGD6_MOUSE
NC score	0.007771 (rank : 16)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	282	Shared Neighborhood Hits	2
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

NAF1_MOUSE
NC score	0.005796 (rank : 17)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	852	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

ZKSC1_MOUSE
NC score	0.003869 (rank : 18)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	755	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGS3, Q7TS88, Q8BJ55, Q9CRN6	Gene names	Zkscan1
Domain Architecture	No domain graphic available
Description	Zinc finger with KRAB and SCAN domain-containing protein 1.