Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : FGD5_MOUSE

For an explanation of this page, click here

FGD5_MOUSE
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD5_HUMAN
θ value	0 (rank : 1)	NC score	0.978701 (rank : 2)
Query Neighborhood Hits	170	Target Neighborhood Hits	235	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	170	Target Neighborhood Hits	170	Shared Neighborhood Hits	170
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
θ value	2.52267e-127 (rank : 3)	NC score	0.902333 (rank : 3)
Query Neighborhood Hits	170	Target Neighborhood Hits	237	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	3.4095e-124 (rank : 4)	NC score	0.896220 (rank : 4)
Query Neighborhood Hits	170	Target Neighborhood Hits	282	Shared Neighborhood Hits	112
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD4_HUMAN
θ value	1.97229e-55 (rank : 5)	NC score	0.818578 (rank : 6)
Query Neighborhood Hits	170	Target Neighborhood Hits	219	Shared Neighborhood Hits	104
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	1.08223e-53 (rank : 6)	NC score	0.816090 (rank : 7)
Query Neighborhood Hits	170	Target Neighborhood Hits	227	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
θ value	1.46268e-50 (rank : 7)	NC score	0.815693 (rank : 8)
Query Neighborhood Hits	170	Target Neighborhood Hits	367	Shared Neighborhood Hits	103
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	2.1121e-49 (rank : 8)	NC score	0.813712 (rank : 10)
Query Neighborhood Hits	170	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	5.38352e-45 (rank : 9)	NC score	0.819707 (rank : 5)
Query Neighborhood Hits	170	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	8.04462e-41 (rank : 10)	NC score	0.815481 (rank : 9)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	8.32485e-38 (rank : 11)	NC score	0.792274 (rank : 11)
Query Neighborhood Hits	170	Target Neighborhood Hits	249	Shared Neighborhood Hits	96
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	1.08726e-37 (rank : 12)	NC score	0.777622 (rank : 12)
Query Neighborhood Hits	170	Target Neighborhood Hits	257	Shared Neighborhood Hits	104
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FARP2_MOUSE
θ value	1.92365e-26 (rank : 13)	NC score	0.491085 (rank : 26)
Query Neighborhood Hits	170	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	2.12685e-25 (rank : 14)	NC score	0.489406 (rank : 27)
Query Neighborhood Hits	170	Target Neighborhood Hits	240	Shared Neighborhood Hits	76
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	6.40375e-22 (rank : 15)	NC score	0.462878 (rank : 29)
Query Neighborhood Hits	170	Target Neighborhood Hits	241	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_MOUSE
θ value	3.63628e-17 (rank : 16)	NC score	0.724888 (rank : 14)
Query Neighborhood Hits	170	Target Neighborhood Hits	80	Shared Neighborhood Hits	56
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
θ value	1.058e-16 (rank : 17)	NC score	0.727091 (rank : 13)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	56
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHG1_HUMAN
θ value	1.058e-16 (rank : 18)	NC score	0.488348 (rank : 28)
Query Neighborhood Hits	170	Target Neighborhood Hits	174	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHF2_HUMAN
θ value	1.68911e-14 (rank : 19)	NC score	0.715993 (rank : 15)
Query Neighborhood Hits	170	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.68911e-14 (rank : 20)	NC score	0.715581 (rank : 16)
Query Neighborhood Hits	170	Target Neighborhood Hits	77	Shared Neighborhood Hits	59
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PREX1_HUMAN
θ value	2.0648e-12 (rank : 21)	NC score	0.491293 (rank : 25)
Query Neighborhood Hits	170	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ZFY16_HUMAN
θ value	3.52202e-12 (rank : 22)	NC score	0.547082 (rank : 21)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	2.28291e-11 (rank : 23)	NC score	0.555372 (rank : 19)
Query Neighborhood Hits	170	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ECT2_MOUSE
θ value	2.52405e-10 (rank : 24)	NC score	0.512838 (rank : 23)
Query Neighborhood Hits	170	Target Neighborhood Hits	98	Shared Neighborhood Hits	53
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ZFYV9_HUMAN
θ value	3.29651e-10 (rank : 25)	NC score	0.561682 (rank : 17)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ECT2_HUMAN
θ value	1.25267e-09 (rank : 26)	NC score	0.503373 (rank : 24)
Query Neighborhood Hits	170	Target Neighborhood Hits	98	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EEA1_MOUSE
θ value	2.13673e-09 (rank : 27)	NC score	0.201529 (rank : 107)
Query Neighborhood Hits	170	Target Neighborhood Hits	1637	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
θ value	3.64472e-09 (rank : 28)	NC score	0.185940 (rank : 114)
Query Neighborhood Hits	170	Target Neighborhood Hits	1796	Shared Neighborhood Hits	79
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ARHGA_MOUSE
θ value	2.36244e-08 (rank : 29)	NC score	0.427184 (rank : 31)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

OBSCN_HUMAN
θ value	2.36244e-08 (rank : 30)	NC score	0.082842 (rank : 131)
Query Neighborhood Hits	170	Target Neighborhood Hits	1931	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TRIO_HUMAN
θ value	3.08544e-08 (rank : 31)	NC score	0.154519 (rank : 121)
Query Neighborhood Hits	170	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

WDFY3_HUMAN
θ value	3.08544e-08 (rank : 32)	NC score	0.318373 (rank : 58)
Query Neighborhood Hits	170	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	3.08544e-08 (rank : 33)	NC score	0.319305 (rank : 57)
Query Neighborhood Hits	170	Target Neighborhood Hits	332	Shared Neighborhood Hits	54
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

DUET_HUMAN
θ value	5.26297e-08 (rank : 34)	NC score	0.156526 (rank : 119)
Query Neighborhood Hits	170	Target Neighborhood Hits	1220	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHGA_HUMAN
θ value	1.17247e-07 (rank : 35)	NC score	0.426829 (rank : 32)
Query Neighborhood Hits	170	Target Neighborhood Hits	187	Shared Neighborhood Hits	46
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ANFY1_HUMAN
θ value	1.99992e-07 (rank : 36)	NC score	0.212442 (rank : 98)
Query Neighborhood Hits	170	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	1.99992e-07 (rank : 37)	NC score	0.212778 (rank : 97)
Query Neighborhood Hits	170	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ARHGG_MOUSE
θ value	1.99992e-07 (rank : 38)	NC score	0.392580 (rank : 40)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	48
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
θ value	3.41135e-07 (rank : 39)	NC score	0.411149 (rank : 36)
Query Neighborhood Hits	170	Target Neighborhood Hits	129	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FYCO1_HUMAN
θ value	4.45536e-07 (rank : 40)	NC score	0.220236 (rank : 93)
Query Neighborhood Hits	170	Target Neighborhood Hits	1149	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

HGS_HUMAN
θ value	4.45536e-07 (rank : 41)	NC score	0.417973 (rank : 34)
Query Neighborhood Hits	170	Target Neighborhood Hits	517	Shared Neighborhood Hits	58
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	5.81887e-07 (rank : 42)	NC score	0.418846 (rank : 33)
Query Neighborhood Hits	170	Target Neighborhood Hits	589	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

PKHA6_HUMAN
θ value	1.29631e-06 (rank : 43)	NC score	0.272647 (rank : 79)
Query Neighborhood Hits	170	Target Neighborhood Hits	556	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RUFY2_HUMAN
θ value	1.69304e-06 (rank : 44)	NC score	0.246311 (rank : 85)
Query Neighborhood Hits	170	Target Neighborhood Hits	1208	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	1.69304e-06 (rank : 45)	NC score	0.305188 (rank : 65)
Query Neighborhood Hits	170	Target Neighborhood Hits	820	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

PKHA6_MOUSE
θ value	2.21117e-06 (rank : 46)	NC score	0.265518 (rank : 81)
Query Neighborhood Hits	170	Target Neighborhood Hits	591	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FYCO1_MOUSE
θ value	2.88788e-06 (rank : 47)	NC score	0.201787 (rank : 106)
Query Neighborhood Hits	170	Target Neighborhood Hits	1059	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

HAPIP_HUMAN
θ value	2.88788e-06 (rank : 48)	NC score	0.385992 (rank : 42)
Query Neighborhood Hits	170	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

RUFY1_MOUSE
θ value	3.77169e-06 (rank : 49)	NC score	0.301328 (rank : 66)
Query Neighborhood Hits	170	Target Neighborhood Hits	765	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ZFY21_HUMAN
θ value	6.43352e-06 (rank : 50)	NC score	0.546185 (rank : 22)
Query Neighborhood Hits	170	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	8.40245e-06 (rank : 51)	NC score	0.550767 (rank : 20)
Query Neighborhood Hits	170	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

RUFY1_HUMAN
θ value	1.09739e-05 (rank : 52)	NC score	0.295117 (rank : 67)
Query Neighborhood Hits	170	Target Neighborhood Hits	848	Shared Neighborhood Hits	67
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ZFY28_HUMAN
θ value	1.87187e-05 (rank : 53)	NC score	0.556021 (rank : 18)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHG5_HUMAN
θ value	5.44631e-05 (rank : 54)	NC score	0.427555 (rank : 30)
Query Neighborhood Hits	170	Target Neighborhood Hits	172	Shared Neighborhood Hits	50
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ITSN2_MOUSE
θ value	5.44631e-05 (rank : 55)	NC score	0.228954 (rank : 89)
Query Neighborhood Hits	170	Target Neighborhood Hits	1371	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG2_MOUSE
θ value	0.000121331 (rank : 56)	NC score	0.361456 (rank : 47)
Query Neighborhood Hits	170	Target Neighborhood Hits	120	Shared Neighborhood Hits	46
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ABR_HUMAN
θ value	0.000270298 (rank : 57)	NC score	0.315659 (rank : 59)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
θ value	0.000270298 (rank : 58)	NC score	0.315493 (rank : 60)
Query Neighborhood Hits	170	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

MCF2_HUMAN
θ value	0.000270298 (rank : 59)	NC score	0.390382 (rank : 41)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MTMR3_HUMAN
θ value	0.00035302 (rank : 60)	NC score	0.293845 (rank : 70)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PKHA5_HUMAN
θ value	0.00035302 (rank : 61)	NC score	0.203357 (rank : 105)
Query Neighborhood Hits	170	Target Neighborhood Hits	455	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

WDFY1_HUMAN
θ value	0.00035302 (rank : 62)	NC score	0.309300 (rank : 63)
Query Neighborhood Hits	170	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RASA2_MOUSE
θ value	0.000461057 (rank : 63)	NC score	0.074892 (rank : 139)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RBNS5_HUMAN
θ value	0.000602161 (rank : 64)	NC score	0.396811 (rank : 38)
Query Neighborhood Hits	170	Target Neighborhood Hits	242	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.000602161 (rank : 65)	NC score	0.392822 (rank : 39)
Query Neighborhood Hits	170	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFYV1_HUMAN
θ value	0.000786445 (rank : 66)	NC score	0.411881 (rank : 35)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

CNKR2_MOUSE
θ value	0.00134147 (rank : 67)	NC score	0.163217 (rank : 117)
Query Neighborhood Hits	170	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ZFYV1_MOUSE
θ value	0.00134147 (rank : 68)	NC score	0.406857 (rank : 37)
Query Neighborhood Hits	170	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

CNKR2_HUMAN
θ value	0.00175202 (rank : 69)	NC score	0.162598 (rank : 118)
Query Neighborhood Hits	170	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA4_HUMAN
θ value	0.00298849 (rank : 70)	NC score	0.199142 (rank : 108)
Query Neighborhood Hits	170	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

FYV1_HUMAN
θ value	0.00390308 (rank : 71)	NC score	0.347352 (rank : 51)
Query Neighborhood Hits	170	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	0.00390308 (rank : 72)	NC score	0.345010 (rank : 53)
Query Neighborhood Hits	170	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

PKHA4_MOUSE
θ value	0.00509761 (rank : 73)	NC score	0.203640 (rank : 103)
Query Neighborhood Hits	170	Target Neighborhood Hits	202	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

ARHG1_MOUSE
θ value	0.00665767 (rank : 74)	NC score	0.312525 (rank : 62)
Query Neighborhood Hits	170	Target Neighborhood Hits	266	Shared Neighborhood Hits	43
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PKHG4_HUMAN
θ value	0.00665767 (rank : 75)	NC score	0.373551 (rank : 44)
Query Neighborhood Hits	170	Target Neighborhood Hits	200	Shared Neighborhood Hits	42
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SOS1_HUMAN
θ value	0.00869519 (rank : 76)	NC score	0.186533 (rank : 112)
Query Neighborhood Hits	170	Target Neighborhood Hits	274	Shared Neighborhood Hits	29
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHG1_HUMAN
θ value	0.0113563 (rank : 77)	NC score	0.313089 (rank : 61)
Query Neighborhood Hits	170	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

MCF2L_MOUSE
θ value	0.0113563 (rank : 78)	NC score	0.358037 (rank : 48)
Query Neighborhood Hits	170	Target Neighborhood Hits	255	Shared Neighborhood Hits	54
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

RASA2_HUMAN
θ value	0.0113563 (rank : 79)	NC score	0.062349 (rank : 148)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	16
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

WDFY2_HUMAN
θ value	0.0113563 (rank : 80)	NC score	0.280831 (rank : 76)
Query Neighborhood Hits	170	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.0113563 (rank : 81)	NC score	0.282966 (rank : 75)
Query Neighborhood Hits	170	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ARHG2_HUMAN
θ value	0.0193708 (rank : 82)	NC score	0.279459 (rank : 77)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
θ value	0.0330416 (rank : 83)	NC score	0.275147 (rank : 78)
Query Neighborhood Hits	170	Target Neighborhood Hits	351	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SOS1_MOUSE
θ value	0.0431538 (rank : 84)	NC score	0.172106 (rank : 115)
Query Neighborhood Hits	170	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG8_MOUSE
θ value	0.0563607 (rank : 85)	NC score	0.225216 (rank : 91)
Query Neighborhood Hits	170	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG8_HUMAN
θ value	0.0736092 (rank : 86)	NC score	0.285183 (rank : 74)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ZFY19_HUMAN
θ value	0.0736092 (rank : 87)	NC score	0.350067 (rank : 50)
Query Neighborhood Hits	170	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY27_HUMAN
θ value	0.0961366 (rank : 88)	NC score	0.237339 (rank : 87)
Query Neighborhood Hits	170	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	0.0961366 (rank : 89)	NC score	0.243127 (rank : 86)
Query Neighborhood Hits	170	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ARHGC_MOUSE
θ value	0.125558 (rank : 90)	NC score	0.267682 (rank : 80)
Query Neighborhood Hits	170	Target Neighborhood Hits	344	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SOS2_HUMAN
θ value	0.163984 (rank : 91)	NC score	0.190664 (rank : 111)
Query Neighborhood Hits	170	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ARHGF_HUMAN
θ value	0.21417 (rank : 92)	NC score	0.367012 (rank : 46)
Query Neighborhood Hits	170	Target Neighborhood Hits	214	Shared Neighborhood Hits	49
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

OSBL9_HUMAN
θ value	0.21417 (rank : 93)	NC score	0.087267 (rank : 125)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	30
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

CNKR1_HUMAN
θ value	0.279714 (rank : 94)	NC score	0.156301 (rank : 120)
Query Neighborhood Hits	170	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH3_HUMAN
θ value	0.365318 (rank : 95)	NC score	0.084174 (rank : 129)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH3_MOUSE
θ value	0.365318 (rank : 96)	NC score	0.097720 (rank : 123)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH4_MOUSE
θ value	0.62314 (rank : 97)	NC score	0.086533 (rank : 127)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

KCNQ2_HUMAN
θ value	0.62314 (rank : 98)	NC score	0.015219 (rank : 204)
Query Neighborhood Hits	170	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

CKAP2_MOUSE
θ value	0.813845 (rank : 99)	NC score	0.030658 (rank : 187)
Query Neighborhood Hits	170	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

KCNQ2_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.014964 (rank : 205)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

PHF3_HUMAN
θ value	0.813845 (rank : 101)	NC score	0.021090 (rank : 192)
Query Neighborhood Hits	170	Target Neighborhood Hits	419	Shared Neighborhood Hits	9
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

RASA3_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.055558 (rank : 170)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	24
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

TCF17_MOUSE
θ value	0.813845 (rank : 103)	NC score	-0.002854 (rank : 226)
Query Neighborhood Hits	170	Target Neighborhood Hits	786	Shared Neighborhood Hits	8
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

ZFY19_MOUSE
θ value	0.813845 (rank : 104)	NC score	0.329108 (rank : 56)
Query Neighborhood Hits	170	Target Neighborhood Hits	143	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

AB1IP_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.019539 (rank : 194)
Query Neighborhood Hits	170	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

NGEF_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.382979 (rank : 43)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ZN486_HUMAN
θ value	1.06291 (rank : 107)	NC score	0.001001 (rank : 223)
Query Neighborhood Hits	170	Target Neighborhood Hits	645	Shared Neighborhood Hits	6
SwissProt Accessions	Q96H40	Gene names	ZNF486, KRBO2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 486.

MTMRD_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.055902 (rank : 169)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	26
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

P52K_HUMAN
θ value	1.38821 (rank : 109)	NC score	0.017376 (rank : 199)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	O43422, Q8WTW1, Q9Y3Z4	Gene names	PRKRIR, DAP4, P52RIPK, THAP0
Domain Architecture
Description	52 kDa repressor of the inhibitor of the protein kinase (p58IPK- interacting protein) (58 kDa interferon-induced protein kinase- interacting protein) (P52rIPK) (Death-associated protein 4) (THAP domain-containing protein 0).

TR95_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.018832 (rank : 196)
Query Neighborhood Hits	170	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2X0, Q6PJT2, Q96AD4, Q96I35, Q9Y652	Gene names	THRAP5, DRIP92
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 95 kDa component (Trap95) (Thyroid hormone receptor-associated protein 5) (Vitamin D3 receptor-interacting protein complex component DRIP92).

ZN646_HUMAN
θ value	1.38821 (rank : 111)	NC score	-0.001247 (rank : 224)
Query Neighborhood Hits	170	Target Neighborhood Hits	813	Shared Neighborhood Hits	11
SwissProt Accessions	O15015	Gene names	ZNF646, KIAA0296
Domain Architecture	No domain graphic available
Description	Zinc finger protein 646.

CYH1_HUMAN
θ value	1.81305 (rank : 112)	NC score	0.081798 (rank : 132)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	48
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	1.81305 (rank : 113)	NC score	0.079239 (rank : 135)
Query Neighborhood Hits	170	Target Neighborhood Hits	176	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

GOGA3_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.038538 (rank : 182)
Query Neighborhood Hits	170	Target Neighborhood Hits	1317	Shared Neighborhood Hits	30
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.047896 (rank : 180)
Query Neighborhood Hits	170	Target Neighborhood Hits	1437	Shared Neighborhood Hits	34
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PRG3_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.014540 (rank : 207)
Query Neighborhood Hits	170	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JL95, Q3SXA9	Gene names	Prg3, Mbp2
Domain Architecture	No domain graphic available
Description	Proteoglycan 3 precursor (Eosinophil major basic protein 2).

RABE2_HUMAN
θ value	1.81305 (rank : 117)	NC score	0.037952 (rank : 184)
Query Neighborhood Hits	170	Target Neighborhood Hits	545	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

SO5A1_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.007935 (rank : 217)
Query Neighborhood Hits	170	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2Y9	Gene names	SLCO5A1, SLC21A15
Domain Architecture
Description	Solute carrier organic anion transporter family member 5A1 (Solute carrier family 21 member 15) (Organic anion transporter polypeptide- related protein 4) (OATP-RP4) (OATPRP4).

ZCH13_HUMAN
θ value	1.81305 (rank : 119)	NC score	0.049105 (rank : 179)
Query Neighborhood Hits	170	Target Neighborhood Hits	151	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

ZDHC1_MOUSE
θ value	1.81305 (rank : 120)	NC score	0.022023 (rank : 191)
Query Neighborhood Hits	170	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0N9, Q8BJ24	Gene names	Zdhhc1
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1).

ERIC1_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.022425 (rank : 190)
Query Neighborhood Hits	170	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

GNRP_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.307351 (rank : 64)
Query Neighborhood Hits	170	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MAP1B_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.017096 (rank : 201)
Query Neighborhood Hits	170	Target Neighborhood Hits	903	Shared Neighborhood Hits	24
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

P66A_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.013677 (rank : 209)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

RFFL_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.077786 (rank : 137)
Query Neighborhood Hits	170	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

STAP1_HUMAN
θ value	2.36792 (rank : 126)	NC score	0.020020 (rank : 193)
Query Neighborhood Hits	170	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

CEND1_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.045279 (rank : 181)
Query Neighborhood Hits	170	Target Neighborhood Hits	284	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CYH4_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.079798 (rank : 134)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

GNRP_HUMAN
θ value	3.0926 (rank : 129)	NC score	0.294328 (rank : 69)
Query Neighborhood Hits	170	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

HXK1_MOUSE
θ value	3.0926 (rank : 130)	NC score	0.007502 (rank : 219)
Query Neighborhood Hits	170	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P17710, Q61659, Q64476, Q64479	Gene names	Hk1
Domain Architecture
Description	Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme).

NCOR1_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.009675 (rank : 215)
Query Neighborhood Hits	170	Target Neighborhood Hits	577	Shared Neighborhood Hits	14
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

TAF3_MOUSE
θ value	3.0926 (rank : 132)	NC score	0.017164 (rank : 200)
Query Neighborhood Hits	170	Target Neighborhood Hits	463	Shared Neighborhood Hits	10
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

ARHG7_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.251436 (rank : 82)
Query Neighborhood Hits	170	Target Neighborhood Hits	347	Shared Neighborhood Hits	55
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ASPH_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.016445 (rank : 203)
Query Neighborhood Hits	170	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

BAK_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.010977 (rank : 211)
Query Neighborhood Hits	170	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

CAPON_HUMAN
θ value	4.03905 (rank : 136)	NC score	0.018222 (rank : 197)
Query Neighborhood Hits	170	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CAPON_MOUSE
θ value	4.03905 (rank : 137)	NC score	0.031436 (rank : 186)
Query Neighborhood Hits	170	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

FLNB_HUMAN
θ value	4.03905 (rank : 138)	NC score	0.009909 (rank : 214)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	7
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

FLNB_MOUSE
θ value	4.03905 (rank : 139)	NC score	0.010377 (rank : 213)
Query Neighborhood Hits	170	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

NGEF_MOUSE
θ value	4.03905 (rank : 140)	NC score	0.370044 (rank : 45)
Query Neighborhood Hits	170	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

REST_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.027629 (rank : 189)
Query Neighborhood Hits	170	Target Neighborhood Hits	1605	Shared Neighborhood Hits	37
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RNF34_MOUSE
θ value	4.03905 (rank : 142)	NC score	0.083239 (rank : 130)
Query Neighborhood Hits	170	Target Neighborhood Hits	160	Shared Neighborhood Hits	37
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

ZC3H6_HUMAN
θ value	4.03905 (rank : 143)	NC score	0.014638 (rank : 206)
Query Neighborhood Hits	170	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

C43BP_HUMAN
θ value	5.27518 (rank : 144)	NC score	0.060068 (rank : 156)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

EP15_HUMAN
θ value	5.27518 (rank : 145)	NC score	0.029256 (rank : 188)
Query Neighborhood Hits	170	Target Neighborhood Hits	1021	Shared Neighborhood Hits	27
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

PJA1_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.007681 (rank : 218)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

RFFL_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.085673 (rank : 128)
Query Neighborhood Hits	170	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.078442 (rank : 136)
Query Neighborhood Hits	170	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

TCF17_HUMAN
θ value	5.27518 (rank : 149)	NC score	-0.004607 (rank : 227)
Query Neighborhood Hits	170	Target Neighborhood Hits	797	Shared Neighborhood Hits	6
SwissProt Accessions	O60765, Q9UNJ8	Gene names	ZNF354A, EZNF, HKL1, TCF17
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Zinc finger protein eZNF).

UBP10_MOUSE
θ value	5.27518 (rank : 150)	NC score	0.009173 (rank : 216)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

VAV2_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.209057 (rank : 100)
Query Neighborhood Hits	170	Target Neighborhood Hits	456	Shared Neighborhood Hits	54
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

C43BP_MOUSE
θ value	6.88961 (rank : 152)	NC score	0.059684 (rank : 157)
Query Neighborhood Hits	170	Target Neighborhood Hits	91	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

LIMA1_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.005397 (rank : 221)
Query Neighborhood Hits	170	Target Neighborhood Hits	309	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

MYCB2_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.012990 (rank : 210)
Query Neighborhood Hits	170	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYH3_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.017922 (rank : 198)
Query Neighborhood Hits	170	Target Neighborhood Hits	1660	Shared Neighborhood Hits	29
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYT1_HUMAN
θ value	6.88961 (rank : 156)	NC score	0.010480 (rank : 212)
Query Neighborhood Hits	170	Target Neighborhood Hits	475	Shared Neighborhood Hits	20
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

PLEK_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.067357 (rank : 146)
Query Neighborhood Hits	170	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

ZDHC1_HUMAN
θ value	6.88961 (rank : 158)	NC score	0.014364 (rank : 208)
Query Neighborhood Hits	170	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

AMOL1_HUMAN
θ value	8.99809 (rank : 159)	NC score	0.019441 (rank : 195)
Query Neighborhood Hits	170	Target Neighborhood Hits	435	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ATRX_MOUSE
θ value	8.99809 (rank : 160)	NC score	0.005769 (rank : 220)
Query Neighborhood Hits	170	Target Neighborhood Hits	682	Shared Neighborhood Hits	16
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

CYH2_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.071770 (rank : 144)
Query Neighborhood Hits	170	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	8.99809 (rank : 162)	NC score	0.071782 (rank : 143)
Query Neighborhood Hits	170	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

DGKH_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.061560 (rank : 150)
Query Neighborhood Hits	170	Target Neighborhood Hits	255	Shared Neighborhood Hits	41
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

FANCM_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.004078 (rank : 222)
Query Neighborhood Hits	170	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

NKX25_MOUSE
θ value	8.99809 (rank : 165)	NC score	-0.001884 (rank : 225)
Query Neighborhood Hits	170	Target Neighborhood Hits	347	Shared Neighborhood Hits	2
SwissProt Accessions	P42582, P97335	Gene names	Nkx2-5, Csx, Nkx-2.5, Nkx2e
Domain Architecture
Description	Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) (Cardiac- specific homeobox) (Homeobox protein CSX).

PSD4_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.038492 (rank : 183)
Query Neighborhood Hits	170	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RKHD1_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.016686 (rank : 202)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

TARA_HUMAN
θ value	8.99809 (rank : 168)	NC score	0.032310 (rank : 185)
Query Neighborhood Hits	170	Target Neighborhood Hits	1626	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TIAM1_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.294627 (rank : 68)
Query Neighborhood Hits	170	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	8.99809 (rank : 170)	NC score	0.292570 (rank : 71)
Query Neighborhood Hits	170	Target Neighborhood Hits	205	Shared Neighborhood Hits	59
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

3BP2_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.068244 (rank : 145)
Query Neighborhood Hits	170	Target Neighborhood Hits	296	Shared Neighborhood Hits	25
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

3BP2_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.064954 (rank : 147)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.061056 (rank : 152)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.059613 (rank : 158)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	8
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ALS2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.092668 (rank : 124)
Query Neighborhood Hits	170	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.106697 (rank : 122)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG3_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.247037 (rank : 83)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.246662 (rank : 84)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.347130 (rank : 52)
Query Neighborhood Hits	170	Target Neighborhood Hits	242	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.351468 (rank : 49)
Query Neighborhood Hits	170	Target Neighborhood Hits	185	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.186028 (rank : 113)
Query Neighborhood Hits	170	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.166431 (rank : 116)
Query Neighborhood Hits	170	Target Neighborhood Hits	394	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.226775 (rank : 90)
Query Neighborhood Hits	170	Target Neighborhood Hits	396	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG9_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.337843 (rank : 54)
Query Neighborhood Hits	170	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.335925 (rank : 55)
Query Neighborhood Hits	170	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGB_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.287131 (rank : 73)
Query Neighborhood Hits	170	Target Neighborhood Hits	375	Shared Neighborhood Hits	49
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

CJ064_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.061869 (rank : 149)
Query Neighborhood Hits	170	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

DNMBP_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.203565 (rank : 104)
Query Neighborhood Hits	170	Target Neighborhood Hits	413	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.209781 (rank : 99)
Query Neighborhood Hits	170	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

E41L1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.057608 (rank : 165)
Query Neighborhood Hits	170	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.057903 (rank : 164)
Query Neighborhood Hits	170	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.057501 (rank : 167)
Query Neighborhood Hits	170	Target Neighborhood Hits	287	Shared Neighborhood Hits	7
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.058137 (rank : 163)
Query Neighborhood Hits	170	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.060673 (rank : 153)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.059345 (rank : 159)
Query Neighborhood Hits	170	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.060554 (rank : 154)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LA_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.054994 (rank : 171)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.054391 (rank : 172)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LB_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.061223 (rank : 151)
Query Neighborhood Hits	170	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.060527 (rank : 155)
Query Neighborhood Hits	170	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.058750 (rank : 161)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.059143 (rank : 160)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

ITSN1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.214144 (rank : 95)
Query Neighborhood Hits	170	Target Neighborhood Hits	1757	Shared Neighborhood Hits	74
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.213049 (rank : 96)
Query Neighborhood Hits	170	Target Neighborhood Hits	1669	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.232466 (rank : 88)
Query Neighborhood Hits	170	Target Neighborhood Hits	1173	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LBC_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.289710 (rank : 72)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MOES_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.050413 (rank : 178)
Query Neighborhood Hits	170	Target Neighborhood Hits	923	Shared Neighborhood Hits	25
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYLIP_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.053086 (rank : 176)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.053176 (rank : 175)
Query Neighborhood Hits	170	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

PKHA1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.053532 (rank : 173)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.053247 (rank : 174)
Query Neighborhood Hits	170	Target Neighborhood Hits	120	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.073535 (rank : 141)
Query Neighborhood Hits	170	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.086815 (rank : 126)
Query Neighborhood Hits	170	Target Neighborhood Hits	116	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA3_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.057586 (rank : 166)
Query Neighborhood Hits	170	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.056125 (rank : 168)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PLEK_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.058727 (rank : 162)
Query Neighborhood Hits	170	Target Neighborhood Hits	109	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

RASA3_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.052533 (rank : 177)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	21
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

RGNEF_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.198202 (rank : 109)
Query Neighborhood Hits	170	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY3_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.072920 (rank : 142)
Query Neighborhood Hits	170	Target Neighborhood Hits	594	Shared Neighborhood Hits	15
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.074078 (rank : 140)
Query Neighborhood Hits	170	Target Neighborhood Hits	579	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SWP70_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.080383 (rank : 133)
Query Neighborhood Hits	170	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.077778 (rank : 138)
Query Neighborhood Hits	170	Target Neighborhood Hits	1097	Shared Neighborhood Hits	66
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

VAV2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.193161 (rank : 110)
Query Neighborhood Hits	170	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.205078 (rank : 102)
Query Neighborhood Hits	170	Target Neighborhood Hits	398	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.206205 (rank : 101)
Query Neighborhood Hits	170	Target Neighborhood Hits	404	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.222708 (rank : 92)
Query Neighborhood Hits	170	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.217212 (rank : 94)
Query Neighborhood Hits	170	Target Neighborhood Hits	430	Shared Neighborhood Hits	50
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

FGD5_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	170	Target Neighborhood Hits	170	Shared Neighborhood Hits	170
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.978701 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	170	Target Neighborhood Hits	235	Shared Neighborhood Hits	122
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD6_HUMAN
NC score	0.902333 (rank : 3)	θ value	2.52267e-127 (rank : 3)
Query Neighborhood Hits	170	Target Neighborhood Hits	237	Shared Neighborhood Hits	112
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.896220 (rank : 4)	θ value	3.4095e-124 (rank : 4)
Query Neighborhood Hits	170	Target Neighborhood Hits	282	Shared Neighborhood Hits	112
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD2_HUMAN
NC score	0.819707 (rank : 5)	θ value	5.38352e-45 (rank : 9)
Query Neighborhood Hits	170	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.818578 (rank : 6)	θ value	1.97229e-55 (rank : 5)
Query Neighborhood Hits	170	Target Neighborhood Hits	219	Shared Neighborhood Hits	104
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.816090 (rank : 7)	θ value	1.08223e-53 (rank : 6)
Query Neighborhood Hits	170	Target Neighborhood Hits	227	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
NC score	0.815693 (rank : 8)	θ value	1.46268e-50 (rank : 7)
Query Neighborhood Hits	170	Target Neighborhood Hits	367	Shared Neighborhood Hits	103
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_MOUSE
NC score	0.815481 (rank : 9)	θ value	8.04462e-41 (rank : 10)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_MOUSE
NC score	0.813712 (rank : 10)	θ value	2.1121e-49 (rank : 8)
Query Neighborhood Hits	170	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
NC score	0.792274 (rank : 11)	θ value	8.32485e-38 (rank : 11)
Query Neighborhood Hits	170	Target Neighborhood Hits	249	Shared Neighborhood Hits	96
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.777622 (rank : 12)	θ value	1.08726e-37 (rank : 12)
Query Neighborhood Hits	170	Target Neighborhood Hits	257	Shared Neighborhood Hits	104
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

PKHF1_HUMAN
NC score	0.727091 (rank : 13)	θ value	1.058e-16 (rank : 17)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	56
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.724888 (rank : 14)	θ value	3.63628e-17 (rank : 16)
Query Neighborhood Hits	170	Target Neighborhood Hits	80	Shared Neighborhood Hits	56
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
NC score	0.715993 (rank : 15)	θ value	1.68911e-14 (rank : 19)
Query Neighborhood Hits	170	Target Neighborhood Hits	75	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.715581 (rank : 16)	θ value	1.68911e-14 (rank : 20)
Query Neighborhood Hits	170	Target Neighborhood Hits	77	Shared Neighborhood Hits	59
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ZFYV9_HUMAN
NC score	0.561682 (rank : 17)	θ value	3.29651e-10 (rank : 25)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY28_HUMAN
NC score	0.556021 (rank : 18)	θ value	1.87187e-05 (rank : 53)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFY16_MOUSE
NC score	0.555372 (rank : 19)	θ value	2.28291e-11 (rank : 23)
Query Neighborhood Hits	170	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.550767 (rank : 20)	θ value	8.40245e-06 (rank : 51)
Query Neighborhood Hits	170	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY16_HUMAN
NC score	0.547082 (rank : 21)	θ value	3.52202e-12 (rank : 22)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.546185 (rank : 22)	θ value	6.43352e-06 (rank : 50)
Query Neighborhood Hits	170	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ECT2_MOUSE
NC score	0.512838 (rank : 23)	θ value	2.52405e-10 (rank : 24)
Query Neighborhood Hits	170	Target Neighborhood Hits	98	Shared Neighborhood Hits	53
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.503373 (rank : 24)	θ value	1.25267e-09 (rank : 26)
Query Neighborhood Hits	170	Target Neighborhood Hits	98	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PREX1_HUMAN
NC score	0.491293 (rank : 25)	θ value	2.0648e-12 (rank : 21)
Query Neighborhood Hits	170	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP2_MOUSE
NC score	0.491085 (rank : 26)	θ value	1.92365e-26 (rank : 13)
Query Neighborhood Hits	170	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
NC score	0.489406 (rank : 27)	θ value	2.12685e-25 (rank : 14)
Query Neighborhood Hits	170	Target Neighborhood Hits	240	Shared Neighborhood Hits	76
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PKHG1_HUMAN
NC score	0.488348 (rank : 28)	θ value	1.058e-16 (rank : 18)
Query Neighborhood Hits	170	Target Neighborhood Hits	174	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

FARP1_HUMAN
NC score	0.462878 (rank : 29)	θ value	6.40375e-22 (rank : 15)
Query Neighborhood Hits	170	Target Neighborhood Hits	241	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG5_HUMAN
NC score	0.427555 (rank : 30)	θ value	5.44631e-05 (rank : 54)
Query Neighborhood Hits	170	Target Neighborhood Hits	172	Shared Neighborhood Hits	50
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHGA_MOUSE
NC score	0.427184 (rank : 31)	θ value	2.36244e-08 (rank : 29)
Query Neighborhood Hits	170	Target Neighborhood Hits	125	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.426829 (rank : 32)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	170	Target Neighborhood Hits	187	Shared Neighborhood Hits	46
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HGS_MOUSE
NC score	0.418846 (rank : 33)	θ value	5.81887e-07 (rank : 42)
Query Neighborhood Hits	170	Target Neighborhood Hits	589	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.417973 (rank : 34)	θ value	4.45536e-07 (rank : 41)
Query Neighborhood Hits	170	Target Neighborhood Hits	517	Shared Neighborhood Hits	58
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZFYV1_HUMAN
NC score	0.411881 (rank : 35)	θ value	0.000786445 (rank : 66)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ARHGG_HUMAN
NC score	0.411149 (rank : 36)	θ value	3.41135e-07 (rank : 39)
Query Neighborhood Hits	170	Target Neighborhood Hits	129	Shared Neighborhood Hits	48
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ZFYV1_MOUSE
NC score	0.406857 (rank : 37)	θ value	0.00134147 (rank : 68)
Query Neighborhood Hits	170	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

RBNS5_HUMAN
NC score	0.396811 (rank : 38)	θ value	0.000602161 (rank : 64)
Query Neighborhood Hits	170	Target Neighborhood Hits	242	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.392822 (rank : 39)	θ value	0.000602161 (rank : 65)
Query Neighborhood Hits	170	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHGG_MOUSE
NC score	0.392580 (rank : 40)	θ value	1.99992e-07 (rank : 38)
Query Neighborhood Hits	170	Target Neighborhood Hits	152	Shared Neighborhood Hits	48
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2_HUMAN
NC score	0.390382 (rank : 41)	θ value	0.000270298 (rank : 59)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	55
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

HAPIP_HUMAN
NC score	0.385992 (rank : 42)	θ value	2.88788e-06 (rank : 48)
Query Neighborhood Hits	170	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NGEF_HUMAN
NC score	0.382979 (rank : 43)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG4_HUMAN
NC score	0.373551 (rank : 44)	θ value	0.00665767 (rank : 75)
Query Neighborhood Hits	170	Target Neighborhood Hits	200	Shared Neighborhood Hits	42
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

NGEF_MOUSE
NC score	0.370044 (rank : 45)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	170	Target Neighborhood Hits	228	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.367012 (rank : 46)	θ value	0.21417 (rank : 92)
Query Neighborhood Hits	170	Target Neighborhood Hits	214	Shared Neighborhood Hits	49
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG2_MOUSE
NC score	0.361456 (rank : 47)	θ value	0.000121331 (rank : 56)
Query Neighborhood Hits	170	Target Neighborhood Hits	120	Shared Neighborhood Hits	46
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

MCF2L_MOUSE
NC score	0.358037 (rank : 48)	θ value	0.0113563 (rank : 78)
Query Neighborhood Hits	170	Target Neighborhood Hits	255	Shared Neighborhood Hits	54
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG4_MOUSE
NC score	0.351468 (rank : 49)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	170	Target Neighborhood Hits	185	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ZFY19_HUMAN
NC score	0.350067 (rank : 50)	θ value	0.0736092 (rank : 87)
Query Neighborhood Hits	170	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FYV1_HUMAN
NC score	0.347352 (rank : 51)	θ value	0.00390308 (rank : 71)
Query Neighborhood Hits	170	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ARHG4_HUMAN
NC score	0.347130 (rank : 52)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	170	Target Neighborhood Hits	242	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FYV1_MOUSE
NC score	0.345010 (rank : 53)	θ value	0.00390308 (rank : 72)
Query Neighborhood Hits	170	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ARHG9_HUMAN
NC score	0.337843 (rank : 54)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	170	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.335925 (rank : 55)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	170	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ZFY19_MOUSE
NC score	0.329108 (rank : 56)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	170	Target Neighborhood Hits	143	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

WDFY3_MOUSE
NC score	0.319305 (rank : 57)	θ value	3.08544e-08 (rank : 33)
Query Neighborhood Hits	170	Target Neighborhood Hits	332	Shared Neighborhood Hits	54
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.318373 (rank : 58)	θ value	3.08544e-08 (rank : 32)
Query Neighborhood Hits	170	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

ABR_HUMAN
NC score	0.315659 (rank : 59)	θ value	0.000270298 (rank : 57)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	47
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.315493 (rank : 60)	θ value	0.000270298 (rank : 58)
Query Neighborhood Hits	170	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG1_HUMAN
NC score	0.313089 (rank : 61)	θ value	0.0113563 (rank : 77)
Query Neighborhood Hits	170	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.312525 (rank : 62)	θ value	0.00665767 (rank : 74)
Query Neighborhood Hits	170	Target Neighborhood Hits	266	Shared Neighborhood Hits	43
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

WDFY1_HUMAN
NC score	0.309300 (rank : 63)	θ value	0.00035302 (rank : 62)
Query Neighborhood Hits	170	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

GNRP_MOUSE
NC score	0.307351 (rank : 64)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	170	Target Neighborhood Hits	191	Shared Neighborhood Hits	62
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

RUFY2_MOUSE
NC score	0.305188 (rank : 65)	θ value	1.69304e-06 (rank : 45)
Query Neighborhood Hits	170	Target Neighborhood Hits	820	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.301328 (rank : 66)	θ value	3.77169e-06 (rank : 49)
Query Neighborhood Hits	170	Target Neighborhood Hits	765	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.295117 (rank : 67)	θ value	1.09739e-05 (rank : 52)
Query Neighborhood Hits	170	Target Neighborhood Hits	848	Shared Neighborhood Hits	67
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TIAM1_HUMAN
NC score	0.294627 (rank : 68)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	170	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GNRP_HUMAN
NC score	0.294328 (rank : 69)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	170	Target Neighborhood Hits	239	Shared Neighborhood Hits	66
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

MTMR3_HUMAN
NC score	0.293845 (rank : 70)	θ value	0.00035302 (rank : 60)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

TIAM1_MOUSE
NC score	0.292570 (rank : 71)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	170	Target Neighborhood Hits	205	Shared Neighborhood Hits	59
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

LBC_HUMAN
NC score	0.289710 (rank : 72)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	170	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGB_HUMAN
NC score	0.287131 (rank : 73)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	170	Target Neighborhood Hits	375	Shared Neighborhood Hits	49
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG8_HUMAN
NC score	0.285183 (rank : 74)	θ value	0.0736092 (rank : 86)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

WDFY2_MOUSE
NC score	0.282966 (rank : 75)	θ value	0.0113563 (rank : 81)
Query Neighborhood Hits	170	Target Neighborhood Hits	337	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.280831 (rank : 76)	θ value	0.0113563 (rank : 80)
Query Neighborhood Hits	170	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

ARHG2_HUMAN
NC score	0.279459 (rank : 77)	θ value	0.0193708 (rank : 82)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
NC score	0.275147 (rank : 78)	θ value	0.0330416 (rank : 83)
Query Neighborhood Hits	170	Target Neighborhood Hits	351	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHA6_HUMAN
NC score	0.272647 (rank : 79)	θ value	1.29631e-06 (rank : 43)
Query Neighborhood Hits	170	Target Neighborhood Hits	556	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHGC_MOUSE
NC score	0.267682 (rank : 80)	θ value	0.125558 (rank : 90)
Query Neighborhood Hits	170	Target Neighborhood Hits	344	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHA6_MOUSE
NC score	0.265518 (rank : 81)	θ value	2.21117e-06 (rank : 46)
Query Neighborhood Hits	170	Target Neighborhood Hits	591	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ARHG7_HUMAN
NC score	0.251436 (rank : 82)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	170	Target Neighborhood Hits	347	Shared Neighborhood Hits	55
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG3_HUMAN
NC score	0.247037 (rank : 83)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	170	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.246662 (rank : 84)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	45
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

RUFY2_HUMAN
NC score	0.246311 (rank : 85)	θ value	1.69304e-06 (rank : 44)
Query Neighborhood Hits	170	Target Neighborhood Hits	1208	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

ZFY27_MOUSE
NC score	0.243127 (rank : 86)	θ value	0.0961366 (rank : 89)
Query Neighborhood Hits	170	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.237339 (rank : 87)	θ value	0.0961366 (rank : 88)
Query Neighborhood Hits	170	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ITSN2_HUMAN
NC score	0.232466 (rank : 88)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	170	Target Neighborhood Hits	1173	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.228954 (rank : 89)	θ value	5.44631e-05 (rank : 55)
Query Neighborhood Hits	170	Target Neighborhood Hits	1371	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG7_MOUSE
NC score	0.226775 (rank : 90)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	170	Target Neighborhood Hits	396	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_MOUSE
NC score	0.225216 (rank : 91)	θ value	0.0563607 (rank : 85)
Query Neighborhood Hits	170	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV_HUMAN
NC score	0.222708 (rank : 92)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	170	Target Neighborhood Hits	452	Shared Neighborhood Hits	51
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

FYCO1_HUMAN
NC score	0.220236 (rank : 93)	θ value	4.45536e-07 (rank : 40)
Query Neighborhood Hits	170	Target Neighborhood Hits	1149	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

VAV_MOUSE
NC score	0.217212 (rank : 94)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	170	Target Neighborhood Hits	430	Shared Neighborhood Hits	50
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ITSN1_HUMAN
NC score	0.214144 (rank : 95)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	170	Target Neighborhood Hits	1757	Shared Neighborhood Hits	74
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.213049 (rank : 96)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	170	Target Neighborhood Hits	1669	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ANFY1_MOUSE
NC score	0.212778 (rank : 97)	θ value	1.99992e-07 (rank : 37)
Query Neighborhood Hits	170	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.212442 (rank : 98)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	170	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

DNMBP_MOUSE
NC score	0.209781 (rank : 99)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	170	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_MOUSE
NC score	0.209057 (rank : 100)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	170	Target Neighborhood Hits	456	Shared Neighborhood Hits	54
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.206205 (rank : 101)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	170	Target Neighborhood Hits	404	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.205078 (rank : 102)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	170	Target Neighborhood Hits	398	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PKHA4_MOUSE
NC score	0.203640 (rank : 103)	θ value	0.00509761 (rank : 73)
Query Neighborhood Hits	170	Target Neighborhood Hits	202	Shared Neighborhood Hits	38
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DNMBP_HUMAN
NC score	0.203565 (rank : 104)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	170	Target Neighborhood Hits	413	Shared Neighborhood Hits	54
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHA5_HUMAN
NC score	0.203357 (rank : 105)	θ value	0.00035302 (rank : 61)
Query Neighborhood Hits	170	Target Neighborhood Hits	455	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

FYCO1_MOUSE
NC score	0.201787 (rank : 106)	θ value	2.88788e-06 (rank : 47)
Query Neighborhood Hits	170	Target Neighborhood Hits	1059	Shared Neighborhood Hits	69
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_MOUSE
NC score	0.201529 (rank : 107)	θ value	2.13673e-09 (rank : 27)
Query Neighborhood Hits	170	Target Neighborhood Hits	1637	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PKHA4_HUMAN
NC score	0.199142 (rank : 108)	θ value	0.00298849 (rank : 70)
Query Neighborhood Hits	170	Target Neighborhood Hits	283	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RGNEF_MOUSE
NC score	0.198202 (rank : 109)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	170	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

VAV2_HUMAN
NC score	0.193161 (rank : 110)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	170	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SOS2_HUMAN
NC score	0.190664 (rank : 111)	θ value	0.163984 (rank : 91)
Query Neighborhood Hits	170	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.186533 (rank : 112)	θ value	0.00869519 (rank : 76)
Query Neighborhood Hits	170	Target Neighborhood Hits	274	Shared Neighborhood Hits	29
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ARHG6_HUMAN
NC score	0.186028 (rank : 113)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	170	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

EEA1_HUMAN
NC score	0.185940 (rank : 114)	θ value	3.64472e-09 (rank : 28)
Query Neighborhood Hits	170	Target Neighborhood Hits	1796	Shared Neighborhood Hits	79
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

SOS1_MOUSE
NC score	0.172106 (rank : 115)	θ value	0.0431538 (rank : 84)
Query Neighborhood Hits	170	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG6_MOUSE
NC score	0.166431 (rank : 116)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	170	Target Neighborhood Hits	394	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CNKR2_MOUSE
NC score	0.163217 (rank : 117)	θ value	0.00134147 (rank : 67)
Query Neighborhood Hits	170	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.162598 (rank : 118)	θ value	0.00175202 (rank : 69)
Query Neighborhood Hits	170	Target Neighborhood Hits	197	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DUET_HUMAN
NC score	0.156526 (rank : 119)	θ value	5.26297e-08 (rank : 34)
Query Neighborhood Hits	170	Target Neighborhood Hits	1220	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

CNKR1_HUMAN
NC score	0.156301 (rank : 120)	θ value	0.279714 (rank : 94)
Query Neighborhood Hits	170	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

TRIO_HUMAN
NC score	0.154519 (rank : 121)	θ value	3.08544e-08 (rank : 31)
Query Neighborhood Hits	170	Target Neighborhood Hits	1580	Shared Neighborhood Hits	71
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ALS2_MOUSE
NC score	0.106697 (rank : 122)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CYH3_MOUSE
NC score	0.097720 (rank : 123)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	170	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

ALS2_HUMAN
NC score	0.092668 (rank : 124)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	170	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

OSBL9_HUMAN
NC score	0.087267 (rank : 125)	θ value	0.21417 (rank : 93)
Query Neighborhood Hits	170	Target Neighborhood Hits	138	Shared Neighborhood Hits	30
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

PKHA2_MOUSE
NC score	0.086815 (rank : 126)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	170	Target Neighborhood Hits	116	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

CYH4_MOUSE
NC score	0.086533 (rank : 127)	θ value	0.62314 (rank : 97)
Query Neighborhood Hits	170	Target Neighborhood Hits	134	Shared Neighborhood Hits	40
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

RFFL_MOUSE
NC score	0.085673 (rank : 128)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	170	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

CYH3_HUMAN
NC score	0.084174 (rank : 129)	θ value	0.365318 (rank : 95)
Query Neighborhood Hits	170	Target Neighborhood Hits	137	Shared Neighborhood Hits	37
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

RNF34_MOUSE
NC score	0.083239 (rank : 130)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	170	Target Neighborhood Hits	160	Shared Neighborhood Hits	37
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

OBSCN_HUMAN
NC score	0.082842 (rank : 131)	θ value	2.36244e-08 (rank : 30)
Query Neighborhood Hits	170	Target Neighborhood Hits	1931	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CYH1_HUMAN
NC score	0.081798 (rank : 132)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	48
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

SWP70_HUMAN
NC score	0.080383 (rank : 133)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	170	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CYH4_HUMAN
NC score	0.079798 (rank : 134)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

CYH1_MOUSE
NC score	0.079239 (rank : 135)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	170	Target Neighborhood Hits	176	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

RNF34_HUMAN
NC score	0.078442 (rank : 136)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	170	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_HUMAN
NC score	0.077786 (rank : 137)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	170	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SWP70_MOUSE
NC score	0.077778 (rank : 138)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	170	Target Neighborhood Hits	1097	Shared Neighborhood Hits	66
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

RASA2_MOUSE
NC score	0.074892 (rank : 139)	θ value	0.000461057 (rank : 63)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	P58069	Gene names	Rasa2
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

RUFY3_MOUSE
NC score	0.074078 (rank : 140)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	170	Target Neighborhood Hits	579	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PKHA2_HUMAN
NC score	0.073535 (rank : 141)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	170	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RUFY3_HUMAN
NC score	0.072920 (rank : 142)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	170	Target Neighborhood Hits	594	Shared Neighborhood Hits	15
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

CYH2_MOUSE
NC score	0.071782 (rank : 143)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	170	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.071770 (rank : 144)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	170	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

3BP2_HUMAN
NC score	0.068244 (rank : 145)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	170	Target Neighborhood Hits	296	Shared Neighborhood Hits	25
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

PLEK_HUMAN
NC score	0.067357 (rank : 146)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	170	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

3BP2_MOUSE
NC score	0.064954 (rank : 147)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

RASA2_HUMAN
NC score	0.062349 (rank : 148)	θ value	0.0113563 (rank : 79)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	16
SwissProt Accessions	Q15283, O00695, Q15284, Q92594, Q99577, Q9UEQ2	Gene names	RASA2, GAP1M, RASGAP
Domain Architecture
Description	Ras GTPase-activating protein 2 (GAP1m).

CJ064_HUMAN
NC score	0.061869 (rank : 149)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	170	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

DGKH_HUMAN
NC score	0.061560 (rank : 150)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	170	Target Neighborhood Hits	255	Shared Neighborhood Hits	41
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

E41LB_HUMAN
NC score	0.061223 (rank : 151)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	170	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

41_HUMAN
NC score	0.061056 (rank : 152)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	170	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

E41L3_HUMAN
NC score	0.060673 (rank : 153)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	170	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L5_HUMAN
NC score	0.060554 (rank : 154)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	170	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.060527 (rank : 155)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	170	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

C43BP_HUMAN
NC score	0.060068 (rank : 156)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
NC score	0.059684 (rank : 157)	θ value	6.88961 (rank : 152)
Query Neighborhood Hits	170	Target Neighborhood Hits	91	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

41_MOUSE
NC score	0.059613 (rank : 158)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	170	Target Neighborhood Hits	184	Shared Neighborhood Hits	8
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

E41L3_MOUSE
NC score	0.059345 (rank : 159)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	170	Target Neighborhood Hits	250	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

FRMD5_MOUSE
NC score	0.059143 (rank : 160)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_HUMAN
NC score	0.058750 (rank : 161)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	170	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

PLEK_MOUSE
NC score	0.058727 (rank : 162)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	170	Target Neighborhood Hits	109	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

E41L2_MOUSE
NC score	0.058137 (rank : 163)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	170	Target Neighborhood Hits	459	Shared Neighborhood Hits	14
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L1_MOUSE
NC score	0.057903 (rank : 164)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	170	Target Neighborhood Hits	106	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_HUMAN
NC score	0.057608 (rank : 165)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	170	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

PKHA3_HUMAN
NC score	0.057586 (rank : 166)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	170	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

E41L2_HUMAN
NC score	0.057501 (rank : 167)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	170	Target Neighborhood Hits	287	Shared Neighborhood Hits	7
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

PKHA3_MOUSE
NC score	0.056125 (rank : 168)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	170	Target Neighborhood Hits	67	Shared Neighborhood Hits	23
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

MTMRD_HUMAN
NC score	0.055902 (rank : 169)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	170	Target Neighborhood Hits	135	Shared Neighborhood Hits	26
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

RASA3_HUMAN
NC score	0.055558 (rank : 170)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	170	Target Neighborhood Hits	166	Shared Neighborhood Hits	24
SwissProt Accessions	Q14644	Gene names	RASA3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein).

E41LA_HUMAN
NC score	0.054994 (rank : 171)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	170	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCS5	Gene names	EPB41L4A, EPB41L4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

E41LA_MOUSE
NC score	0.054391 (rank : 172)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	170	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	P52963	Gene names	Epb41l4a, Epb4.1l4, Epb4.1l4a, Epb41l4
Domain Architecture
Description	Band 4.1-like protein 4A (Protein NBL4).

PKHA1_HUMAN
NC score	0.053532 (rank : 173)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	170	Target Neighborhood Hits	127	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
NC score	0.053247 (rank : 174)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	170	Target Neighborhood Hits	120	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

MYLIP_MOUSE
NC score	0.053176 (rank : 175)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	170	Target Neighborhood Hits	139	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_HUMAN
NC score	0.053086 (rank : 176)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	170	Target Neighborhood Hits	162	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

RASA3_MOUSE
NC score	0.052533 (rank : 177)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	170	Target Neighborhood Hits	144	Shared Neighborhood Hits	21
SwissProt Accessions	Q60790	Gene names	Rasa3
Domain Architecture
Description	Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein) (GapIII).

MOES_MOUSE
NC score	0.050413 (rank : 178)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	170	Target Neighborhood Hits	923	Shared Neighborhood Hits	25
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

ZCH13_HUMAN
NC score	0.049105 (rank : 179)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	170	Target Neighborhood Hits	151	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WW36	Gene names	ZCCHC13
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 13.

GOGA3_MOUSE
NC score	0.047896 (rank : 180)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	170	Target Neighborhood Hits	1437	Shared Neighborhood Hits	34
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

CEND1_HUMAN
NC score	0.045279 (rank : 181)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	170	Target Neighborhood Hits	284	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

GOGA3_HUMAN
NC score	0.038538 (rank : 182)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	170	Target Neighborhood Hits	1317	Shared Neighborhood Hits	30
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

PSD4_HUMAN
NC score	0.038492 (rank : 183)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	170	Target Neighborhood Hits	178	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

RABE2_HUMAN
NC score	0.037952 (rank : 184)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	170	Target Neighborhood Hits	545	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

TARA_HUMAN
NC score	0.032310 (rank : 185)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	170	Target Neighborhood Hits	1626	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CAPON_MOUSE
NC score	0.031436 (rank : 186)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	170	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

CKAP2_MOUSE
NC score	0.030658 (rank : 187)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	170	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q3V1H1, Q66LN2, Q8BSF0	Gene names	Ckap2
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2.

EP15_HUMAN
NC score	0.029256 (rank : 188)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	170	Target Neighborhood Hits	1021	Shared Neighborhood Hits	27
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

REST_HUMAN
NC score	0.027629 (rank : 189)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	170	Target Neighborhood Hits	1605	Shared Neighborhood Hits	37
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

ERIC1_HUMAN
NC score	0.022425 (rank : 190)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	170	Target Neighborhood Hits	364	Shared Neighborhood Hits	9
SwissProt Accessions	Q86X53, Q9P063	Gene names	ERICH1
Domain Architecture	No domain graphic available
Description	Glutamate-rich protein 1.

ZDHC1_MOUSE
NC score	0.022023 (rank : 191)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	170	Target Neighborhood Hits	57	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R0N9, Q8BJ24	Gene names	Zdhhc1
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1).

PHF3_HUMAN
NC score	0.021090 (rank : 192)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	170	Target Neighborhood Hits	419	Shared Neighborhood Hits	9
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

STAP1_HUMAN
NC score	0.020020 (rank : 193)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	170	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

AB1IP_MOUSE
NC score	0.019539 (rank : 194)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	170	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

AMOL1_HUMAN
NC score	0.019441 (rank : 195)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	170	Target Neighborhood Hits	435	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

TR95_HUMAN
NC score	0.018832 (rank : 196)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	170	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2X0, Q6PJT2, Q96AD4, Q96I35, Q9Y652	Gene names	THRAP5, DRIP92
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein complex 95 kDa component (Trap95) (Thyroid hormone receptor-associated protein 5) (Vitamin D3 receptor-interacting protein complex component DRIP92).

CAPON_HUMAN
NC score	0.018222 (rank : 197)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	170	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

MYH3_HUMAN
NC score	0.017922 (rank : 198)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	170	Target Neighborhood Hits	1660	Shared Neighborhood Hits	29
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

P52K_HUMAN
NC score	0.017376 (rank : 199)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	170	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	O43422, Q8WTW1, Q9Y3Z4	Gene names	PRKRIR, DAP4, P52RIPK, THAP0
Domain Architecture
Description	52 kDa repressor of the inhibitor of the protein kinase (p58IPK- interacting protein) (58 kDa interferon-induced protein kinase- interacting protein) (P52rIPK) (Death-associated protein 4) (THAP domain-containing protein 0).

TAF3_MOUSE
NC score	0.017164 (rank : 200)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	170	Target Neighborhood Hits	463	Shared Neighborhood Hits	10
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

MAP1B_HUMAN
NC score	0.017096 (rank : 201)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	170	Target Neighborhood Hits	903	Shared Neighborhood Hits	24
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

RKHD1_HUMAN
NC score	0.016686 (rank : 202)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	7
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

ASPH_HUMAN
NC score	0.016445 (rank : 203)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	170	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

KCNQ2_HUMAN
NC score	0.015219 (rank : 204)	θ value	0.62314 (rank : 98)
Query Neighborhood Hits	170	Target Neighborhood Hits	114	Shared Neighborhood Hits	3
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
NC score	0.014964 (rank : 205)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	170	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

ZC3H6_HUMAN
NC score	0.014638 (rank : 206)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	170	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	P61129	Gene names	ZC3H6, KIAA2035, ZC3HDC6
Domain Architecture
Description	Zinc finger CCCH domain-containing protein 6.

PRG3_MOUSE
NC score	0.014540 (rank : 207)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	170	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JL95, Q3SXA9	Gene names	Prg3, Mbp2
Domain Architecture	No domain graphic available
Description	Proteoglycan 3 precursor (Eosinophil major basic protein 2).

ZDHC1_HUMAN
NC score	0.014364 (rank : 208)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	170	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WTX9, O15461	Gene names	ZDHHC1, C16orf1, ZNF377
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC1 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 1) (DHHC-1) (Zinc finger protein 377) (DHHC- domain-containing cysteine-rich protein 1).

P66A_HUMAN
NC score	0.013677 (rank : 209)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

MYCB2_MOUSE
NC score	0.012990 (rank : 210)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	170	Target Neighborhood Hits	307	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

BAK_MOUSE
NC score	0.010977 (rank : 211)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	170	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

MYT1_HUMAN
NC score	0.010480 (rank : 212)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	170	Target Neighborhood Hits	475	Shared Neighborhood Hits	20
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

FLNB_MOUSE
NC score	0.010377 (rank : 213)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	170	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

FLNB_HUMAN
NC score	0.009909 (rank : 214)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	170	Target Neighborhood Hits	111	Shared Neighborhood Hits	7
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

NCOR1_HUMAN
NC score	0.009675 (rank : 215)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	170	Target Neighborhood Hits	577	Shared Neighborhood Hits	14
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

UBP10_MOUSE
NC score	0.009173 (rank : 216)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	170	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

SO5A1_HUMAN
NC score	0.007935 (rank : 217)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	170	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2Y9	Gene names	SLCO5A1, SLC21A15
Domain Architecture
Description	Solute carrier organic anion transporter family member 5A1 (Solute carrier family 21 member 15) (Organic anion transporter polypeptide- related protein 4) (OATP-RP4) (OATPRP4).

PJA1_HUMAN
NC score	0.007681 (rank : 218)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	170	Target Neighborhood Hits	159	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

HXK1_MOUSE
NC score	0.007502 (rank : 219)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	170	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P17710, Q61659, Q64476, Q64479	Gene names	Hk1
Domain Architecture
Description	Hexokinase-1 (EC 2.7.1.1) (Hexokinase type I) (HK I) (Hexokinase, tumor isozyme).

ATRX_MOUSE
NC score	0.005769 (rank : 220)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	170	Target Neighborhood Hits	682	Shared Neighborhood Hits	16
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

LIMA1_HUMAN
NC score	0.005397 (rank : 221)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	170	Target Neighborhood Hits	309	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UHB6, Q2TAN7, Q9BVF2, Q9H8J1, Q9HBN5, Q9NX96, Q9NXC3, Q9NXU6, Q9P0H8, Q9UHB5	Gene names	LIMA1, EPLIN, SREBP3
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm).

FANCM_HUMAN
NC score	0.004078 (rank : 222)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	170	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

ZN486_HUMAN
NC score	0.001001 (rank : 223)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	170	Target Neighborhood Hits	645	Shared Neighborhood Hits	6
SwissProt Accessions	Q96H40	Gene names	ZNF486, KRBO2
Domain Architecture	No domain graphic available
Description	Zinc finger protein 486.

ZN646_HUMAN
NC score	-0.001247 (rank : 224)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	170	Target Neighborhood Hits	813	Shared Neighborhood Hits	11
SwissProt Accessions	O15015	Gene names	ZNF646, KIAA0296
Domain Architecture	No domain graphic available
Description	Zinc finger protein 646.

NKX25_MOUSE
NC score	-0.001884 (rank : 225)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	170	Target Neighborhood Hits	347	Shared Neighborhood Hits	2
SwissProt Accessions	P42582, P97335	Gene names	Nkx2-5, Csx, Nkx-2.5, Nkx2e
Domain Architecture
Description	Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) (Cardiac- specific homeobox) (Homeobox protein CSX).

TCF17_MOUSE
NC score	-0.002854 (rank : 226)	θ value	0.813845 (rank : 103)
Query Neighborhood Hits	170	Target Neighborhood Hits	786	Shared Neighborhood Hits	8
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

TCF17_HUMAN
NC score	-0.004607 (rank : 227)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	170	Target Neighborhood Hits	797	Shared Neighborhood Hits	6
SwissProt Accessions	O60765, Q9UNJ8	Gene names	ZNF354A, EZNF, HKL1, TCF17
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Zinc finger protein eZNF).