Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PKHG4_HUMAN

For an explanation of this page, click here

PKHG4_HUMAN
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHG4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	200	Target Neighborhood Hits	200	Shared Neighborhood Hits	200
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

TRIO_HUMAN
θ value	2.1121e-49 (rank : 2)	NC score	0.279825 (rank : 54)
Query Neighborhood Hits	200	Target Neighborhood Hits	1580	Shared Neighborhood Hits	75
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
θ value	1.08474e-45 (rank : 3)	NC score	0.261109 (rank : 59)
Query Neighborhood Hits	200	Target Neighborhood Hits	1220	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

HAPIP_HUMAN
θ value	2.34062e-40 (rank : 4)	NC score	0.704147 (rank : 5)
Query Neighborhood Hits	200	Target Neighborhood Hits	350	Shared Neighborhood Hits	66
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MCF2_HUMAN
θ value	6.81017e-40 (rank : 5)	NC score	0.794573 (rank : 2)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MCF2L_MOUSE
θ value	3.73686e-38 (rank : 6)	NC score	0.762293 (rank : 3)
Query Neighborhood Hits	200	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

PKHG1_HUMAN
θ value	1.57365e-28 (rank : 7)	NC score	0.713698 (rank : 4)
Query Neighborhood Hits	200	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

OBSCN_HUMAN
θ value	4.9032e-22 (rank : 8)	NC score	0.165796 (rank : 76)
Query Neighborhood Hits	200	Target Neighborhood Hits	1931	Shared Neighborhood Hits	109
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

FGD4_MOUSE
θ value	1.74796e-11 (rank : 9)	NC score	0.508537 (rank : 16)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	2.28291e-11 (rank : 10)	NC score	0.507535 (rank : 18)
Query Neighborhood Hits	200	Target Neighborhood Hits	219	Shared Neighborhood Hits	56
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PREX1_HUMAN
θ value	2.98157e-11 (rank : 11)	NC score	0.577584 (rank : 6)
Query Neighborhood Hits	200	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

DNMBP_HUMAN
θ value	6.64225e-11 (rank : 12)	NC score	0.436434 (rank : 25)
Query Neighborhood Hits	200	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
θ value	5.62301e-10 (rank : 13)	NC score	0.473030 (rank : 21)
Query Neighborhood Hits	200	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FGD2_MOUSE
θ value	7.34386e-10 (rank : 14)	NC score	0.508451 (rank : 17)
Query Neighborhood Hits	200	Target Neighborhood Hits	163	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

TIAM1_MOUSE
θ value	4.76016e-09 (rank : 15)	NC score	0.541242 (rank : 11)
Query Neighborhood Hits	200	Target Neighborhood Hits	205	Shared Neighborhood Hits	57
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
θ value	1.06045e-08 (rank : 16)	NC score	0.471565 (rank : 22)
Query Neighborhood Hits	200	Target Neighborhood Hits	347	Shared Neighborhood Hits	60
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
θ value	1.80886e-08 (rank : 17)	NC score	0.434408 (rank : 26)
Query Neighborhood Hits	200	Target Neighborhood Hits	435	Shared Neighborhood Hits	62
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG4_HUMAN
θ value	4.0297e-08 (rank : 18)	NC score	0.554231 (rank : 8)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD3_HUMAN
θ value	8.97725e-08 (rank : 19)	NC score	0.519556 (rank : 14)
Query Neighborhood Hits	200	Target Neighborhood Hits	249	Shared Neighborhood Hits	69
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	8.97725e-08 (rank : 20)	NC score	0.533696 (rank : 12)
Query Neighborhood Hits	200	Target Neighborhood Hits	257	Shared Neighborhood Hits	64
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TIAM1_HUMAN
θ value	8.97725e-08 (rank : 21)	NC score	0.532844 (rank : 13)
Query Neighborhood Hits	200	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
θ value	1.53129e-07 (rank : 22)	NC score	0.570930 (rank : 7)
Query Neighborhood Hits	200	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD2_HUMAN
θ value	2.61198e-07 (rank : 23)	NC score	0.510695 (rank : 15)
Query Neighborhood Hits	200	Target Neighborhood Hits	151	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

VAV_HUMAN
θ value	9.92553e-07 (rank : 24)	NC score	0.366148 (rank : 39)
Query Neighborhood Hits	200	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	1.29631e-06 (rank : 25)	NC score	0.371898 (rank : 38)
Query Neighborhood Hits	200	Target Neighborhood Hits	430	Shared Neighborhood Hits	56
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG9_HUMAN
θ value	4.92598e-06 (rank : 26)	NC score	0.541783 (rank : 10)
Query Neighborhood Hits	200	Target Neighborhood Hits	235	Shared Neighborhood Hits	60
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	4.92598e-06 (rank : 27)	NC score	0.541887 (rank : 9)
Query Neighborhood Hits	200	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG6_HUMAN
θ value	1.87187e-05 (rank : 28)	NC score	0.445263 (rank : 24)
Query Neighborhood Hits	200	Target Neighborhood Hits	376	Shared Neighborhood Hits	52
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	3.19293e-05 (rank : 29)	NC score	0.428652 (rank : 30)
Query Neighborhood Hits	200	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FGD6_HUMAN
θ value	3.19293e-05 (rank : 30)	NC score	0.425930 (rank : 32)
Query Neighborhood Hits	200	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	0.00020696 (rank : 31)	NC score	0.428271 (rank : 31)
Query Neighborhood Hits	200	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ARHGA_HUMAN
θ value	0.00035302 (rank : 32)	NC score	0.432186 (rank : 28)
Query Neighborhood Hits	200	Target Neighborhood Hits	187	Shared Neighborhood Hits	56
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_MOUSE
θ value	0.00035302 (rank : 33)	NC score	0.447322 (rank : 23)
Query Neighborhood Hits	200	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD1_HUMAN
θ value	0.000602161 (rank : 34)	NC score	0.475028 (rank : 19)
Query Neighborhood Hits	200	Target Neighborhood Hits	367	Shared Neighborhood Hits	71
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FARP1_HUMAN
θ value	0.000786445 (rank : 35)	NC score	0.295291 (rank : 53)
Query Neighborhood Hits	200	Target Neighborhood Hits	241	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHG5_HUMAN
θ value	0.00102713 (rank : 36)	NC score	0.362819 (rank : 41)
Query Neighborhood Hits	200	Target Neighborhood Hits	172	Shared Neighborhood Hits	57
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FARP2_MOUSE
θ value	0.00134147 (rank : 37)	NC score	0.344046 (rank : 42)
Query Neighborhood Hits	200	Target Neighborhood Hits	209	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	0.00175202 (rank : 38)	NC score	0.333324 (rank : 46)
Query Neighborhood Hits	200	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGA_MOUSE
θ value	0.00390308 (rank : 39)	NC score	0.432963 (rank : 27)
Query Neighborhood Hits	200	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD1_MOUSE
θ value	0.00390308 (rank : 40)	NC score	0.474128 (rank : 20)
Query Neighborhood Hits	200	Target Neighborhood Hits	387	Shared Neighborhood Hits	82
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SPTN5_HUMAN
θ value	0.00509761 (rank : 41)	NC score	0.078252 (rank : 106)
Query Neighborhood Hits	200	Target Neighborhood Hits	674	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

VAV2_MOUSE
θ value	0.00509761 (rank : 42)	NC score	0.338400 (rank : 44)
Query Neighborhood Hits	200	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FGD5_MOUSE
θ value	0.00665767 (rank : 43)	NC score	0.373551 (rank : 37)
Query Neighborhood Hits	200	Target Neighborhood Hits	170	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PTN9_MOUSE
θ value	0.00665767 (rank : 44)	NC score	0.038062 (rank : 258)
Query Neighborhood Hits	200	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

DUS8_HUMAN
θ value	0.00869519 (rank : 45)	NC score	0.040348 (rank : 253)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

FGD5_HUMAN
θ value	0.00869519 (rank : 46)	NC score	0.379495 (rank : 36)
Query Neighborhood Hits	200	Target Neighborhood Hits	235	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ARHGF_HUMAN
θ value	0.0113563 (rank : 47)	NC score	0.313153 (rank : 51)
Query Neighborhood Hits	200	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

VAV2_HUMAN
θ value	0.0113563 (rank : 48)	NC score	0.333990 (rank : 45)
Query Neighborhood Hits	200	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CO5A1_HUMAN
θ value	0.0148317 (rank : 49)	NC score	0.085312 (rank : 98)
Query Neighborhood Hits	200	Target Neighborhood Hits	434	Shared Neighborhood Hits	55
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
θ value	0.0148317 (rank : 50)	NC score	0.085391 (rank : 97)
Query Neighborhood Hits	200	Target Neighborhood Hits	419	Shared Neighborhood Hits	55
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

PTN9_HUMAN
θ value	0.0148317 (rank : 51)	NC score	0.036596 (rank : 260)
Query Neighborhood Hits	200	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

ECT2_HUMAN
θ value	0.0193708 (rank : 52)	NC score	0.431200 (rank : 29)
Query Neighborhood Hits	200	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EMID2_HUMAN
θ value	0.0193708 (rank : 53)	NC score	0.091606 (rank : 90)
Query Neighborhood Hits	200	Target Neighborhood Hits	226	Shared Neighborhood Hits	42
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

TB182_HUMAN
θ value	0.0330416 (rank : 54)	NC score	0.084629 (rank : 101)
Query Neighborhood Hits	200	Target Neighborhood Hits	414	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

THYG_MOUSE
θ value	0.0330416 (rank : 55)	NC score	0.030390 (rank : 273)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

SFPQ_HUMAN
θ value	0.0431538 (rank : 56)	NC score	0.037622 (rank : 259)
Query Neighborhood Hits	200	Target Neighborhood Hits	986	Shared Neighborhood Hits	35
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

CSKI2_HUMAN
θ value	0.0563607 (rank : 57)	NC score	0.029898 (rank : 274)
Query Neighborhood Hits	200	Target Neighborhood Hits	747	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EMID2_MOUSE
θ value	0.0563607 (rank : 58)	NC score	0.086816 (rank : 96)
Query Neighborhood Hits	200	Target Neighborhood Hits	201	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

OGFR_HUMAN
θ value	0.0736092 (rank : 59)	NC score	0.095373 (rank : 85)
Query Neighborhood Hits	200	Target Neighborhood Hits	1582	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CN032_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.055900 (rank : 212)
Query Neighborhood Hits	200	Target Neighborhood Hits	267	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

K1C15_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.008870 (rank : 335)
Query Neighborhood Hits	200	Target Neighborhood Hits	367	Shared Neighborhood Hits	10
SwissProt Accessions	P19012, Q53XV8, Q9BUG4	Gene names	KRT15, KRTB
Domain Architecture
Description	Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15).

SPTA2_HUMAN
θ value	0.21417 (rank : 62)	NC score	0.108061 (rank : 81)
Query Neighborhood Hits	200	Target Neighborhood Hits	888	Shared Neighborhood Hits	36
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

FOXC1_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.021128 (rank : 297)
Query Neighborhood Hits	200	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

GGA3_MOUSE
θ value	0.279714 (rank : 64)	NC score	0.027647 (rank : 276)
Query Neighborhood Hits	200	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

SYN1_MOUSE
θ value	0.279714 (rank : 65)	NC score	0.035529 (rank : 263)
Query Neighborhood Hits	200	Target Neighborhood Hits	363	Shared Neighborhood Hits	19
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

ABR_HUMAN
θ value	0.365318 (rank : 66)	NC score	0.273219 (rank : 56)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG3_MOUSE
θ value	0.365318 (rank : 67)	NC score	0.382344 (rank : 34)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_MOUSE
θ value	0.365318 (rank : 68)	NC score	0.364694 (rank : 40)
Query Neighborhood Hits	200	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

CO7A1_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.069480 (rank : 142)
Query Neighborhood Hits	200	Target Neighborhood Hits	807	Shared Neighborhood Hits	68
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CO9A2_HUMAN
θ value	0.365318 (rank : 70)	NC score	0.074290 (rank : 117)
Query Neighborhood Hits	200	Target Neighborhood Hits	261	Shared Neighborhood Hits	46
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

EAF1_HUMAN
θ value	0.365318 (rank : 71)	NC score	0.050236 (rank : 240)
Query Neighborhood Hits	200	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JC9, Q8IW10	Gene names	EAF1
Domain Architecture	No domain graphic available
Description	ELL-associated factor 1.

LRC50_HUMAN
θ value	0.365318 (rank : 72)	NC score	0.038083 (rank : 257)
Query Neighborhood Hits	200	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

ARHG3_HUMAN
θ value	0.47712 (rank : 73)	NC score	0.383409 (rank : 33)
Query Neighborhood Hits	200	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

CO1A1_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.076373 (rank : 111)
Query Neighborhood Hits	200	Target Neighborhood Hits	475	Shared Neighborhood Hits	57
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CPSF6_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.058621 (rank : 192)
Query Neighborhood Hits	200	Target Neighborhood Hits	359	Shared Neighborhood Hits	29
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.058632 (rank : 191)
Query Neighborhood Hits	200	Target Neighborhood Hits	356	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

IRS2_MOUSE
θ value	0.47712 (rank : 77)	NC score	0.040331 (rank : 254)
Query Neighborhood Hits	200	Target Neighborhood Hits	248	Shared Neighborhood Hits	17
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

VAV3_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.332256 (rank : 47)
Query Neighborhood Hits	200	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG8_HUMAN
θ value	0.62314 (rank : 79)	NC score	0.381635 (rank : 35)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BCR_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.263056 (rank : 57)
Query Neighborhood Hits	200	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CSKI1_MOUSE
θ value	0.62314 (rank : 81)	NC score	0.026069 (rank : 278)
Query Neighborhood Hits	200	Target Neighborhood Hits	1031	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CO1A1_MOUSE
θ value	0.813845 (rank : 82)	NC score	0.074867 (rank : 114)
Query Neighborhood Hits	200	Target Neighborhood Hits	457	Shared Neighborhood Hits	57
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO4A3_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.076714 (rank : 108)
Query Neighborhood Hits	200	Target Neighborhood Hits	421	Shared Neighborhood Hits	57
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CO4A4_HUMAN
θ value	0.813845 (rank : 84)	NC score	0.075686 (rank : 112)
Query Neighborhood Hits	200	Target Neighborhood Hits	440	Shared Neighborhood Hits	62
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CO8A1_MOUSE
θ value	0.813845 (rank : 85)	NC score	0.053775 (rank : 218)
Query Neighborhood Hits	200	Target Neighborhood Hits	251	Shared Neighborhood Hits	41
SwissProt Accessions	Q00780, Q9D2V4	Gene names	Col8a1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor.

CSPG5_MOUSE
θ value	0.813845 (rank : 86)	NC score	0.036196 (rank : 262)
Query Neighborhood Hits	200	Target Neighborhood Hits	211	Shared Neighborhood Hits	17
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

EAF1_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.045657 (rank : 246)
Query Neighborhood Hits	200	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D4C5	Gene names	Eaf1
Domain Architecture	No domain graphic available
Description	ELL-associated factor 1.

ERF_HUMAN
θ value	0.813845 (rank : 88)	NC score	0.018989 (rank : 307)
Query Neighborhood Hits	200	Target Neighborhood Hits	162	Shared Neighborhood Hits	17
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

FCRLA_HUMAN
θ value	0.813845 (rank : 89)	NC score	0.039238 (rank : 256)
Query Neighborhood Hits	200	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FOXC1_MOUSE
θ value	0.813845 (rank : 90)	NC score	0.019100 (rank : 306)
Query Neighborhood Hits	200	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

KIF12_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.010515 (rank : 332)
Query Neighborhood Hits	200	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2Z8, O35061	Gene names	Kif12
Domain Architecture
Description	Kinesin-like protein KIF12.

SOS2_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.180341 (rank : 73)
Query Neighborhood Hits	200	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ARHG2_MOUSE
θ value	1.06291 (rank : 93)	NC score	0.276506 (rank : 55)
Query Neighborhood Hits	200	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CNTRB_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.020637 (rank : 300)
Query Neighborhood Hits	200	Target Neighborhood Hits	690	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

FOXO4_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.023756 (rank : 284)
Query Neighborhood Hits	200	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

K0317_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.020897 (rank : 299)
Query Neighborhood Hits	200	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

MYLK2_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.036435 (rank : 261)
Query Neighborhood Hits	200	Target Neighborhood Hits	920	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

O2T34_HUMAN
θ value	1.06291 (rank : 98)	NC score	-0.002584 (rank : 343)
Query Neighborhood Hits	200	Target Neighborhood Hits	863	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGX1, Q6IEY5, Q96R31	Gene names	OR2T34
Domain Architecture	No domain graphic available
Description	Olfactory receptor 2T34 (Olfactory receptor OR1-63).

OR2T3_HUMAN
θ value	1.06291 (rank : 99)	NC score	-0.002621 (rank : 344)
Query Neighborhood Hits	200	Target Neighborhood Hits	868	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NH03	Gene names	OR2T3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 2T3.

SYNE1_HUMAN
θ value	1.06291 (rank : 100)	NC score	0.043596 (rank : 249)
Query Neighborhood Hits	200	Target Neighborhood Hits	1484	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CO4A5_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.062951 (rank : 172)
Query Neighborhood Hits	200	Target Neighborhood Hits	383	Shared Neighborhood Hits	57
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

CO8A1_HUMAN
θ value	1.38821 (rank : 102)	NC score	0.055348 (rank : 215)
Query Neighborhood Hits	200	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

COGA1_HUMAN
θ value	1.38821 (rank : 103)	NC score	0.063874 (rank : 164)
Query Neighborhood Hits	200	Target Neighborhood Hits	345	Shared Neighborhood Hits	50
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

COJA1_HUMAN
θ value	1.38821 (rank : 104)	NC score	0.072557 (rank : 122)
Query Neighborhood Hits	200	Target Neighborhood Hits	323	Shared Neighborhood Hits	50
SwissProt Accessions	Q14993, Q00559, Q05850, Q12885, Q13676, Q5JUF0, Q5T424, Q9H572, Q9NPZ2, Q9NQP2	Gene names	COL19A1
Domain Architecture
Description	Collagen alpha-1(XIX) chain precursor (Collagen alpha-1(Y) chain).

GMIP_MOUSE
θ value	1.38821 (rank : 105)	NC score	0.021404 (rank : 295)
Query Neighborhood Hits	200	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

PP1RA_HUMAN
θ value	1.38821 (rank : 106)	NC score	0.039967 (rank : 255)
Query Neighborhood Hits	200	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

SRBP1_HUMAN
θ value	1.38821 (rank : 107)	NC score	0.023476 (rank : 285)
Query Neighborhood Hits	200	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

WDR33_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.031637 (rank : 272)
Query Neighborhood Hits	200	Target Neighborhood Hits	638	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

ACBD4_HUMAN
θ value	1.81305 (rank : 109)	NC score	0.032448 (rank : 268)
Query Neighborhood Hits	200	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NC06, Q8IUT1, Q9H8Q4	Gene names	ACBD4
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 4.

AKAP9_HUMAN
θ value	1.81305 (rank : 110)	NC score	0.023894 (rank : 282)
Query Neighborhood Hits	200	Target Neighborhood Hits	1710	Shared Neighborhood Hits	35
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

CUTL1_HUMAN
θ value	1.81305 (rank : 111)	NC score	0.013790 (rank : 320)
Query Neighborhood Hits	200	Target Neighborhood Hits	1574	Shared Neighborhood Hits	34
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

FRAT1_MOUSE
θ value	1.81305 (rank : 112)	NC score	0.026715 (rank : 277)
Query Neighborhood Hits	200	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P70339	Gene names	Frat1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

K0317_HUMAN
θ value	1.81305 (rank : 113)	NC score	0.019568 (rank : 303)
Query Neighborhood Hits	200	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

RP3A_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.010359 (rank : 333)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SRRM2_HUMAN
θ value	1.81305 (rank : 115)	NC score	0.031827 (rank : 271)
Query Neighborhood Hits	200	Target Neighborhood Hits	1296	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TAF4_HUMAN
θ value	1.81305 (rank : 116)	NC score	0.041807 (rank : 251)
Query Neighborhood Hits	200	Target Neighborhood Hits	687	Shared Neighborhood Hits	37
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

ARHG2_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.251252 (rank : 62)
Query Neighborhood Hits	200	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

B3A3_MOUSE
θ value	2.36792 (rank : 118)	NC score	0.010899 (rank : 331)
Query Neighborhood Hits	200	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

BCL9_MOUSE
θ value	2.36792 (rank : 119)	NC score	0.063249 (rank : 168)
Query Neighborhood Hits	200	Target Neighborhood Hits	770	Shared Neighborhood Hits	77
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CNOT3_MOUSE
θ value	2.36792 (rank : 120)	NC score	0.032560 (rank : 267)
Query Neighborhood Hits	200	Target Neighborhood Hits	504	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO2A1_HUMAN
θ value	2.36792 (rank : 121)	NC score	0.075002 (rank : 113)
Query Neighborhood Hits	200	Target Neighborhood Hits	486	Shared Neighborhood Hits	66
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

GNAS1_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.022919 (rank : 287)
Query Neighborhood Hits	200	Target Neighborhood Hits	651	Shared Neighborhood Hits	57
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HSF1_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.022124 (rank : 290)
Query Neighborhood Hits	200	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IRX1_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.017967 (rank : 309)
Query Neighborhood Hits	200	Target Neighborhood Hits	285	Shared Neighborhood Hits	8
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

KCNN3_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.012156 (rank : 324)
Query Neighborhood Hits	200	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

PHC1_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.021895 (rank : 292)
Query Neighborhood Hits	200	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

PRPC_HUMAN
θ value	2.36792 (rank : 127)	NC score	0.057927 (rank : 196)
Query Neighborhood Hits	200	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

SON_HUMAN
θ value	2.36792 (rank : 128)	NC score	0.058613 (rank : 193)
Query Neighborhood Hits	200	Target Neighborhood Hits	1568	Shared Neighborhood Hits	92
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ULK1_HUMAN
θ value	2.36792 (rank : 129)	NC score	0.026026 (rank : 279)
Query Neighborhood Hits	200	Target Neighborhood Hits	1121	Shared Neighborhood Hits	52
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

CABL1_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.017491 (rank : 310)
Query Neighborhood Hits	200	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

COCA1_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.045620 (rank : 247)
Query Neighborhood Hits	200	Target Neighborhood Hits	458	Shared Neighborhood Hits	43
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COHA1_MOUSE
θ value	3.0926 (rank : 132)	NC score	0.063724 (rank : 165)
Query Neighborhood Hits	200	Target Neighborhood Hits	414	Shared Neighborhood Hits	51
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CSKI2_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.023867 (rank : 283)
Query Neighborhood Hits	200	Target Neighborhood Hits	812	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

FOXO4_MOUSE
θ value	3.0926 (rank : 134)	NC score	0.020187 (rank : 302)
Query Neighborhood Hits	200	Target Neighborhood Hits	168	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

HAIR_MOUSE
θ value	3.0926 (rank : 135)	NC score	0.021464 (rank : 294)
Query Neighborhood Hits	200	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

HCN2_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.014707 (rank : 318)
Query Neighborhood Hits	200	Target Neighborhood Hits	369	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

NOL1_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.028079 (rank : 275)
Query Neighborhood Hits	200	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

SALL3_HUMAN
θ value	3.0926 (rank : 138)	NC score	0.004677 (rank : 339)
Query Neighborhood Hits	200	Target Neighborhood Hits	1066	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TRI47_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.011210 (rank : 330)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

ZN598_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.021894 (rank : 293)
Query Neighborhood Hits	200	Target Neighborhood Hits	339	Shared Neighborhood Hits	15
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

CO3A1_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.069599 (rank : 141)
Query Neighborhood Hits	200	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO3A1_MOUSE
θ value	4.03905 (rank : 142)	NC score	0.071627 (rank : 127)
Query Neighborhood Hits	200	Target Neighborhood Hits	466	Shared Neighborhood Hits	55
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO9A1_MOUSE
θ value	4.03905 (rank : 143)	NC score	0.074507 (rank : 115)
Query Neighborhood Hits	200	Target Neighborhood Hits	477	Shared Neighborhood Hits	66
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

COEA1_HUMAN
θ value	4.03905 (rank : 144)	NC score	0.048188 (rank : 244)
Query Neighborhood Hits	200	Target Neighborhood Hits	427	Shared Neighborhood Hits	43
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COEA1_MOUSE
θ value	4.03905 (rank : 145)	NC score	0.040397 (rank : 252)
Query Neighborhood Hits	200	Target Neighborhood Hits	402	Shared Neighborhood Hits	44
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

IRS2_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.032074 (rank : 270)
Query Neighborhood Hits	200	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

K1849_HUMAN
θ value	4.03905 (rank : 147)	NC score	0.011923 (rank : 326)
Query Neighborhood Hits	200	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

MK15_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.014424 (rank : 319)
Query Neighborhood Hits	200	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

PCDH8_HUMAN
θ value	4.03905 (rank : 149)	NC score	0.001053 (rank : 342)
Query Neighborhood Hits	200	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

PERQ1_MOUSE
θ value	4.03905 (rank : 150)	NC score	0.022575 (rank : 289)
Query Neighborhood Hits	200	Target Neighborhood Hits	215	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

PHAR2_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.015151 (rank : 315)
Query Neighborhood Hits	200	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

PLEC1_HUMAN
θ value	4.03905 (rank : 152)	NC score	0.019191 (rank : 305)
Query Neighborhood Hits	200	Target Neighborhood Hits	1326	Shared Neighborhood Hits	27
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SNIP_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.021323 (rank : 296)
Query Neighborhood Hits	200	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

TTC7A_MOUSE
θ value	4.03905 (rank : 154)	NC score	0.014983 (rank : 316)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGB2, Q80XT5	Gene names	Ttc7a, Ttc7
Domain Architecture
Description	Tetratricopeptide repeat protein 7A (TPR repeat protein 7).

ZSWM5_MOUSE
θ value	4.03905 (rank : 155)	NC score	0.013446 (rank : 321)
Query Neighborhood Hits	200	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q80TC6	Gene names	Zswim5, Kiaa1511
Domain Architecture	No domain graphic available
Description	Zinc finger SWIM domain-containing protein 5.

CO2A1_MOUSE
θ value	5.27518 (rank : 156)	NC score	0.071940 (rank : 125)
Query Neighborhood Hits	200	Target Neighborhood Hits	483	Shared Neighborhood Hits	63
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO9A2_MOUSE
θ value	5.27518 (rank : 157)	NC score	0.070930 (rank : 131)
Query Neighborhood Hits	200	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

COBA2_MOUSE
θ value	5.27518 (rank : 158)	NC score	0.077495 (rank : 107)
Query Neighborhood Hits	200	Target Neighborhood Hits	501	Shared Neighborhood Hits	64
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

COCA1_MOUSE
θ value	5.27518 (rank : 159)	NC score	0.044469 (rank : 248)
Query Neighborhood Hits	200	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

DAXX_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.019351 (rank : 304)
Query Neighborhood Hits	200	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

DNM3A_HUMAN
θ value	5.27518 (rank : 161)	NC score	0.011269 (rank : 329)
Query Neighborhood Hits	200	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

IRX1_MOUSE
θ value	5.27518 (rank : 162)	NC score	0.012919 (rank : 322)
Query Neighborhood Hits	200	Target Neighborhood Hits	269	Shared Neighborhood Hits	3
SwissProt Accessions	P81068, O55120, Q9JLL6	Gene names	Irx1, Irxa1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

MAGE1_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.045762 (rank : 245)
Query Neighborhood Hits	200	Target Neighborhood Hits	1389	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MLL2_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.035023 (rank : 264)
Query Neighborhood Hits	200	Target Neighborhood Hits	1788	Shared Neighborhood Hits	90
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NUMA1_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.025169 (rank : 280)
Query Neighborhood Hits	200	Target Neighborhood Hits	1523	Shared Neighborhood Hits	30
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

UBP42_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.018145 (rank : 308)
Query Neighborhood Hits	200	Target Neighborhood Hits	445	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ARHGG_HUMAN
θ value	6.88961 (rank : 167)	NC score	0.339099 (rank : 43)
Query Neighborhood Hits	200	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CDAN1_HUMAN
θ value	6.88961 (rank : 168)	NC score	0.022871 (rank : 288)
Query Neighborhood Hits	200	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWY9, Q7Z7L5, Q969N3	Gene names	CDAN1
Domain Architecture	No domain graphic available
Description	Codanin-1.

COFA1_HUMAN
θ value	6.88961 (rank : 169)	NC score	0.053410 (rank : 220)
Query Neighborhood Hits	200	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

CSTF2_MOUSE
θ value	6.88961 (rank : 170)	NC score	0.005257 (rank : 338)
Query Neighborhood Hits	200	Target Neighborhood Hits	255	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BIQ5, Q8K1Y6, Q9ERC2	Gene names	Cstf2
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

DAXX_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.020597 (rank : 301)
Query Neighborhood Hits	200	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

GSCR1_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.025098 (rank : 281)
Query Neighborhood Hits	200	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MAVS_HUMAN
θ value	6.88961 (rank : 173)	NC score	0.023446 (rank : 286)
Query Neighborhood Hits	200	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MLL4_HUMAN
θ value	6.88961 (rank : 174)	NC score	0.016788 (rank : 312)
Query Neighborhood Hits	200	Target Neighborhood Hits	722	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PEPL_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.012140 (rank : 325)
Query Neighborhood Hits	200	Target Neighborhood Hits	1141	Shared Neighborhood Hits	23
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

RP1L1_HUMAN
θ value	6.88961 (rank : 176)	NC score	0.032221 (rank : 269)
Query Neighborhood Hits	200	Target Neighborhood Hits	1072	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SHAN1_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.056098 (rank : 209)
Query Neighborhood Hits	200	Target Neighborhood Hits	1041	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TACC3_HUMAN
θ value	6.88961 (rank : 178)	NC score	0.016956 (rank : 311)
Query Neighborhood Hits	200	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TBX1_MOUSE
θ value	6.88961 (rank : 179)	NC score	0.004525 (rank : 340)
Query Neighborhood Hits	200	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P70323, Q60706, Q99MP0, Q99P22	Gene names	Tbx1
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T- box protein).

WBP11_MOUSE
θ value	6.88961 (rank : 180)	NC score	0.033927 (rank : 266)
Query Neighborhood Hits	200	Target Neighborhood Hits	362	Shared Neighborhood Hits	23
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ZBT7A_HUMAN
θ value	6.88961 (rank : 181)	NC score	-0.004915 (rank : 345)
Query Neighborhood Hits	200	Target Neighborhood Hits	823	Shared Neighborhood Hits	8
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).

CAC1C_MOUSE
θ value	8.99809 (rank : 182)	NC score	0.002333 (rank : 341)
Query Neighborhood Hits	200	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CCD96_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.011408 (rank : 328)
Query Neighborhood Hits	200	Target Neighborhood Hits	595	Shared Neighborhood Hits	20
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CEL_HUMAN
θ value	8.99809 (rank : 184)	NC score	0.042152 (rank : 250)
Query Neighborhood Hits	200	Target Neighborhood Hits	896	Shared Neighborhood Hits	77
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CNOT3_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.022001 (rank : 291)
Query Neighborhood Hits	200	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO5A3_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.072680 (rank : 121)
Query Neighborhood Hits	200	Target Neighborhood Hits	433	Shared Neighborhood Hits	62
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

COFA1_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.055995 (rank : 210)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	46
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

COHA1_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.056545 (rank : 205)
Query Neighborhood Hits	200	Target Neighborhood Hits	400	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CONA1_HUMAN
θ value	8.99809 (rank : 189)	NC score	0.069449 (rank : 143)
Query Neighborhood Hits	200	Target Neighborhood Hits	281	Shared Neighborhood Hits	52
SwissProt Accessions	Q86Y22, Q8IVR4, Q9NT93	Gene names	COL23A1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CP250_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.016757 (rank : 313)
Query Neighborhood Hits	200	Target Neighborhood Hits	1805	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

EMID1_MOUSE
θ value	8.99809 (rank : 191)	NC score	0.064683 (rank : 159)
Query Neighborhood Hits	200	Target Neighborhood Hits	230	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

ESPL1_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.012289 (rank : 323)
Query Neighborhood Hits	200	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q14674	Gene names	ESPL1, ESP1, KIAA0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

MUC7_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.016707 (rank : 314)
Query Neighborhood Hits	200	Target Neighborhood Hits	538	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MY18B_HUMAN
θ value	8.99809 (rank : 194)	NC score	0.021000 (rank : 298)
Query Neighborhood Hits	200	Target Neighborhood Hits	1299	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NU107_MOUSE
θ value	8.99809 (rank : 195)	NC score	0.010304 (rank : 334)
Query Neighborhood Hits	200	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BH74, Q99KH5	Gene names	Nup107
Domain Architecture
Description	Nuclear pore complex protein Nup107 (Nucleoporin Nup107) (107 kDa nucleoporin).

PP16B_MOUSE
θ value	8.99809 (rank : 196)	NC score	0.006127 (rank : 337)
Query Neighborhood Hits	200	Target Neighborhood Hits	302	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

PP1RA_MOUSE
θ value	8.99809 (rank : 197)	NC score	0.034227 (rank : 265)
Query Neighborhood Hits	200	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

SUSD4_MOUSE
θ value	8.99809 (rank : 198)	NC score	0.007803 (rank : 336)
Query Neighborhood Hits	200	Target Neighborhood Hits	122	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

SYNJ1_HUMAN
θ value	8.99809 (rank : 199)	NC score	0.014804 (rank : 317)
Query Neighborhood Hits	200	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TNFC_MOUSE
θ value	8.99809 (rank : 200)	NC score	0.011825 (rank : 327)
Query Neighborhood Hits	200	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

ABI1_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.050439 (rank : 237)
Query Neighborhood Hits	200	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.056927 (rank : 200)
Query Neighborhood Hits	200	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.062408 (rank : 175)
Query Neighborhood Hits	200	Target Neighborhood Hits	350	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.058481 (rank : 194)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.053278 (rank : 224)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.053409 (rank : 221)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG1_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.261485 (rank : 58)
Query Neighborhood Hits	200	Target Neighborhood Hits	176	Shared Neighborhood Hits	74
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.244966 (rank : 64)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	91
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGB_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.258357 (rank : 60)
Query Neighborhood Hits	200	Target Neighborhood Hits	375	Shared Neighborhood Hits	63
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.247577 (rank : 63)
Query Neighborhood Hits	200	Target Neighborhood Hits	351	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.235301 (rank : 67)
Query Neighborhood Hits	200	Target Neighborhood Hits	344	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGG_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.320766 (rank : 49)
Query Neighborhood Hits	200	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCAR1_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.058710 (rank : 190)
Query Neighborhood Hits	200	Target Neighborhood Hits	554	Shared Neighborhood Hits	43
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.054480 (rank : 216)
Query Neighborhood Hits	200	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCL9_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.050253 (rank : 239)
Query Neighborhood Hits	200	Target Neighborhood Hits	1008	Shared Neighborhood Hits	78
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CD2AP_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.085253 (rank : 99)
Query Neighborhood Hits	200	Target Neighborhood Hits	315	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.085037 (rank : 100)
Query Neighborhood Hits	200	Target Neighborhood Hits	336	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CO1A2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.065762 (rank : 154)
Query Neighborhood Hits	200	Target Neighborhood Hits	329	Shared Neighborhood Hits	49
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO1A2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.070302 (rank : 136)
Query Neighborhood Hits	200	Target Neighborhood Hits	388	Shared Neighborhood Hits	57
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO4A1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.068373 (rank : 147)
Query Neighborhood Hits	200	Target Neighborhood Hits	425	Shared Neighborhood Hits	57
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO4A1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.068690 (rank : 145)
Query Neighborhood Hits	200	Target Neighborhood Hits	450	Shared Neighborhood Hits	62
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO4A2_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.071459 (rank : 128)
Query Neighborhood Hits	200	Target Neighborhood Hits	454	Shared Neighborhood Hits	64
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO4A2_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.072136 (rank : 123)
Query Neighborhood Hits	200	Target Neighborhood Hits	492	Shared Neighborhood Hits	67
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO4A6_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.068700 (rank : 144)
Query Neighborhood Hits	200	Target Neighborhood Hits	318	Shared Neighborhood Hits	52
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

CO5A2_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.073899 (rank : 118)
Query Neighborhood Hits	200	Target Neighborhood Hits	760	Shared Neighborhood Hits	79
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CO6A1_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.056652 (rank : 202)
Query Neighborhood Hits	200	Target Neighborhood Hits	264	Shared Neighborhood Hits	45
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

CO6A1_MOUSE
θ value	θ > 10 (rank : 227)	NC score	0.052770 (rank : 227)
Query Neighborhood Hits	200	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q04857	Gene names	Col6a1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

CO6A2_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.052022 (rank : 230)
Query Neighborhood Hits	200	Target Neighborhood Hits	249	Shared Neighborhood Hits	43
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

CO6A2_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.052465 (rank : 229)
Query Neighborhood Hits	200	Target Neighborhood Hits	260	Shared Neighborhood Hits	43
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

CO8A2_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.050991 (rank : 232)
Query Neighborhood Hits	200	Target Neighborhood Hits	299	Shared Neighborhood Hits	48
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CO9A1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.068437 (rank : 146)
Query Neighborhood Hits	200	Target Neighborhood Hits	420	Shared Neighborhood Hits	61
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CO9A3_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.067823 (rank : 148)
Query Neighborhood Hits	200	Target Neighborhood Hits	361	Shared Neighborhood Hits	53
SwissProt Accessions	Q14050, Q13681, Q9H4G9, Q9UPE2	Gene names	COL9A3
Domain Architecture	No domain graphic available
Description	Collagen alpha-3(IX) chain precursor.

COAA1_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.055958 (rank : 211)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	48
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

COBA1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.071711 (rank : 126)
Query Neighborhood Hits	200	Target Neighborhood Hits	491	Shared Neighborhood Hits	60
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.070802 (rank : 132)
Query Neighborhood Hits	200	Target Neighborhood Hits	487	Shared Neighborhood Hits	60
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA2_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.072045 (rank : 124)
Query Neighborhood Hits	200	Target Neighborhood Hits	408	Shared Neighborhood Hits	55
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

COIA1_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.056483 (rank : 207)
Query Neighborhood Hits	200	Target Neighborhood Hits	481	Shared Neighborhood Hits	53
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

COLQ_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.053336 (rank : 223)
Query Neighborhood Hits	200	Target Neighborhood Hits	193	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y215, Q6DK18, Q6YH18, Q6YH19, Q6YH20, Q6YH21, Q9NP18, Q9NP19, Q9NP20, Q9NP21, Q9NP22, Q9NP23, Q9NP24, Q9UP88	Gene names	COLQ
Domain Architecture	No domain graphic available
Description	Acetylcholinesterase collagenic tail peptide precursor (AChE Q subunit) (Acetylcholinesterase-associated collagen).

CONA1_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.063982 (rank : 162)
Query Neighborhood Hits	200	Target Neighborhood Hits	254	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CRKL_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.057882 (rank : 197)
Query Neighborhood Hits	200	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.057002 (rank : 199)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.061369 (rank : 180)
Query Neighborhood Hits	200	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.062586 (rank : 174)
Query Neighborhood Hits	200	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DBNL_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.050145 (rank : 242)
Query Neighborhood Hits	200	Target Neighborhood Hits	244	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DIDO1_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.053341 (rank : 222)
Query Neighborhood Hits	200	Target Neighborhood Hits	960	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

EEA1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.054232 (rank : 217)
Query Neighborhood Hits	200	Target Neighborhood Hits	1637	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EMID1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.056895 (rank : 201)
Query Neighborhood Hits	200	Target Neighborhood Hits	215	Shared Neighborhood Hits	40
SwissProt Accessions	Q96A84, Q6ICG1, Q86SS7	Gene names	EMID1, EMU1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

FYV1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.062342 (rank : 176)
Query Neighborhood Hits	200	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.057290 (rank : 198)
Query Neighborhood Hits	200	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

GNRP_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.215269 (rank : 71)
Query Neighborhood Hits	200	Target Neighborhood Hits	239	Shared Neighborhood Hits	52
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.239057 (rank : 66)
Query Neighborhood Hits	200	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP2_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.063465 (rank : 166)
Query Neighborhood Hits	200	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.062338 (rank : 177)
Query Neighborhood Hits	200	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.073373 (rank : 120)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.070145 (rank : 138)
Query Neighborhood Hits	200	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.065624 (rank : 155)
Query Neighborhood Hits	200	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.065494 (rank : 157)
Query Neighborhood Hits	200	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.060795 (rank : 185)
Query Neighborhood Hits	200	Target Neighborhood Hits	358	Shared Neighborhood Hits	24
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.062688 (rank : 173)
Query Neighborhood Hits	200	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.069717 (rank : 140)
Query Neighborhood Hits	200	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.070306 (rank : 135)
Query Neighborhood Hits	200	Target Neighborhood Hits	589	Shared Neighborhood Hits	29
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.073626 (rank : 119)
Query Neighborhood Hits	200	Target Neighborhood Hits	1024	Shared Neighborhood Hits	91
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITSN1_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.220215 (rank : 69)
Query Neighborhood Hits	200	Target Neighborhood Hits	1757	Shared Neighborhood Hits	84
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.220124 (rank : 70)
Query Neighborhood Hits	200	Target Neighborhood Hits	1669	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.242833 (rank : 65)
Query Neighborhood Hits	200	Target Neighborhood Hits	1173	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.227017 (rank : 68)
Query Neighborhood Hits	200	Target Neighborhood Hits	1371	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.252845 (rank : 61)
Query Neighborhood Hits	200	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MARCO_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.056640 (rank : 203)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	43
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

MUC1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.052794 (rank : 226)
Query Neighborhood Hits	200	Target Neighborhood Hits	975	Shared Neighborhood Hits	73
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NCF1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.107926 (rank : 82)
Query Neighborhood Hits	200	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.094042 (rank : 87)
Query Neighborhood Hits	200	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.074360 (rank : 116)
Query Neighborhood Hits	200	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.081326 (rank : 103)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.080770 (rank : 105)
Query Neighborhood Hits	200	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.067367 (rank : 151)
Query Neighborhood Hits	200	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.063911 (rank : 163)
Query Neighborhood Hits	200	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NGEF_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.314955 (rank : 50)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.311213 (rank : 52)
Query Neighborhood Hits	200	Target Neighborhood Hits	228	Shared Neighborhood Hits	55
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NPHP1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.058730 (rank : 189)
Query Neighborhood Hits	200	Target Neighborhood Hits	267	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OBSL1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.052503 (rank : 228)
Query Neighborhood Hits	200	Target Neighborhood Hits	354	Shared Neighborhood Hits	7
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

OGFR_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.070545 (rank : 134)
Query Neighborhood Hits	200	Target Neighborhood Hits	584	Shared Neighborhood Hits	61
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

OSTF1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.061074 (rank : 182)
Query Neighborhood Hits	200	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.060810 (rank : 184)
Query Neighborhood Hits	200	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PEX13_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.050842 (rank : 233)
Query Neighborhood Hits	200	Target Neighborhood Hits	128	Shared Neighborhood Hits	15
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.050554 (rank : 235)
Query Neighborhood Hits	200	Target Neighborhood Hits	126	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.065579 (rank : 156)
Query Neighborhood Hits	200	Target Neighborhood Hits	556	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.055415 (rank : 214)
Query Neighborhood Hits	200	Target Neighborhood Hits	591	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.149835 (rank : 79)
Query Neighborhood Hits	200	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.149077 (rank : 80)
Query Neighborhood Hits	200	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.151160 (rank : 77)
Query Neighborhood Hits	200	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.150954 (rank : 78)
Query Neighborhood Hits	200	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PPIP1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.063309 (rank : 167)
Query Neighborhood Hits	200	Target Neighborhood Hits	389	Shared Neighborhood Hits	21
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.060123 (rank : 187)
Query Neighborhood Hits	200	Target Neighborhood Hits	377	Shared Neighborhood Hits	21
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRRT3_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.058472 (rank : 195)
Query Neighborhood Hits	200	Target Neighborhood Hits	998	Shared Neighborhood Hits	82
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RBNS5_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.076545 (rank : 110)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.071100 (rank : 130)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RGNEF_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.212522 (rank : 72)
Query Neighborhood Hits	200	Target Neighborhood Hits	641	Shared Neighborhood Hits	63
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RGS3_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.053474 (rank : 219)
Query Neighborhood Hits	200	Target Neighborhood Hits	1621	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RUFY1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.050555 (rank : 234)
Query Neighborhood Hits	200	Target Neighborhood Hits	765	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

SH3G1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.065093 (rank : 158)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.063168 (rank : 169)
Query Neighborhood Hits	200	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.060778 (rank : 186)
Query Neighborhood Hits	200	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.059783 (rank : 188)
Query Neighborhood Hits	200	Target Neighborhood Hits	319	Shared Neighborhood Hits	21
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.062982 (rank : 171)
Query Neighborhood Hits	200	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.064358 (rank : 160)
Query Neighborhood Hits	200	Target Neighborhood Hits	236	Shared Neighborhood Hits	18
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.092275 (rank : 89)
Query Neighborhood Hits	200	Target Neighborhood Hits	341	Shared Neighborhood Hits	25
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.088922 (rank : 93)
Query Neighborhood Hits	200	Target Neighborhood Hits	332	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.056469 (rank : 208)
Query Neighborhood Hits	200	Target Neighborhood Hits	446	Shared Neighborhood Hits	28
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOS1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.178573 (rank : 74)
Query Neighborhood Hits	200	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.167517 (rank : 75)
Query Neighborhood Hits	200	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.093627 (rank : 88)
Query Neighborhood Hits	200	Target Neighborhood Hits	748	Shared Neighborhood Hits	32
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.100292 (rank : 84)
Query Neighborhood Hits	200	Target Neighborhood Hits	675	Shared Neighborhood Hits	30
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTB2_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.052896 (rank : 225)
Query Neighborhood Hits	200	Target Neighborhood Hits	748	Shared Neighborhood Hits	27
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.051904 (rank : 231)
Query Neighborhood Hits	200	Target Neighborhood Hits	770	Shared Neighborhood Hits	29
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.050028 (rank : 243)
Query Neighborhood Hits	200	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SPTN4_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.050233 (rank : 241)
Query Neighborhood Hits	200	Target Neighborhood Hits	570	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SRBS1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.081528 (rank : 102)
Query Neighborhood Hits	200	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.071433 (rank : 129)
Query Neighborhood Hits	200	Target Neighborhood Hits	409	Shared Neighborhood Hits	21
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.065857 (rank : 153)
Query Neighborhood Hits	200	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.063991 (rank : 161)
Query Neighborhood Hits	200	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SSBP4_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.060999 (rank : 183)
Query Neighborhood Hits	200	Target Neighborhood Hits	753	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.067647 (rank : 149)
Query Neighborhood Hits	200	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.067628 (rank : 150)
Query Neighborhood Hits	200	Target Neighborhood Hits	232	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.081144 (rank : 104)
Query Neighborhood Hits	200	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.076683 (rank : 109)
Query Neighborhood Hits	200	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.070173 (rank : 137)
Query Neighborhood Hits	200	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.067206 (rank : 152)
Query Neighborhood Hits	200	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.061912 (rank : 178)
Query Neighborhood Hits	200	Target Neighborhood Hits	288	Shared Neighborhood Hits	22
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.062987 (rank : 170)
Query Neighborhood Hits	200	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.061662 (rank : 179)
Query Neighborhood Hits	200	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VAV3_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.325168 (rank : 48)
Query Neighborhood Hits	200	Target Neighborhood Hits	404	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VINEX_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.070080 (rank : 139)
Query Neighborhood Hits	200	Target Neighborhood Hits	270	Shared Neighborhood Hits	19
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.070631 (rank : 133)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WDFY1_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.050504 (rank : 236)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY3_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.050378 (rank : 238)
Query Neighborhood Hits	200	Target Neighborhood Hits	348	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

ZFY16_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.088461 (rank : 94)
Query Neighborhood Hits	200	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.090266 (rank : 91)
Query Neighborhood Hits	200	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY19_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.061247 (rank : 181)
Query Neighborhood Hits	200	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.056632 (rank : 204)
Query Neighborhood Hits	200	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY21_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.087738 (rank : 95)
Query Neighborhood Hits	200	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.089180 (rank : 92)
Query Neighborhood Hits	200	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.100367 (rank : 83)
Query Neighborhood Hits	200	Target Neighborhood Hits	152	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.056517 (rank : 206)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.055550 (rank : 213)
Query Neighborhood Hits	200	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.095072 (rank : 86)
Query Neighborhood Hits	200	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

PKHG4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	200	Target Neighborhood Hits	200	Shared Neighborhood Hits	200
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

MCF2_HUMAN
NC score	0.794573 (rank : 2)	θ value	6.81017e-40 (rank : 5)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MCF2L_MOUSE
NC score	0.762293 (rank : 3)	θ value	3.73686e-38 (rank : 6)
Query Neighborhood Hits	200	Target Neighborhood Hits	255	Shared Neighborhood Hits	62
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

PKHG1_HUMAN
NC score	0.713698 (rank : 4)	θ value	1.57365e-28 (rank : 7)
Query Neighborhood Hits	200	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

HAPIP_HUMAN
NC score	0.704147 (rank : 5)	θ value	2.34062e-40 (rank : 4)
Query Neighborhood Hits	200	Target Neighborhood Hits	350	Shared Neighborhood Hits	66
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

PREX1_HUMAN
NC score	0.577584 (rank : 6)	θ value	2.98157e-11 (rank : 11)
Query Neighborhood Hits	200	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_MOUSE
NC score	0.570930 (rank : 7)	θ value	1.53129e-07 (rank : 22)
Query Neighborhood Hits	200	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.554231 (rank : 8)	θ value	4.0297e-08 (rank : 18)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
NC score	0.541887 (rank : 9)	θ value	4.92598e-06 (rank : 27)
Query Neighborhood Hits	200	Target Neighborhood Hits	234	Shared Neighborhood Hits	60
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.541783 (rank : 10)	θ value	4.92598e-06 (rank : 26)
Query Neighborhood Hits	200	Target Neighborhood Hits	235	Shared Neighborhood Hits	60
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

TIAM1_MOUSE
NC score	0.541242 (rank : 11)	θ value	4.76016e-09 (rank : 15)
Query Neighborhood Hits	200	Target Neighborhood Hits	205	Shared Neighborhood Hits	57
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD3_MOUSE
NC score	0.533696 (rank : 12)	θ value	8.97725e-08 (rank : 20)
Query Neighborhood Hits	200	Target Neighborhood Hits	257	Shared Neighborhood Hits	64
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

TIAM1_HUMAN
NC score	0.532844 (rank : 13)	θ value	8.97725e-08 (rank : 21)
Query Neighborhood Hits	200	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD3_HUMAN
NC score	0.519556 (rank : 14)	θ value	8.97725e-08 (rank : 19)
Query Neighborhood Hits	200	Target Neighborhood Hits	249	Shared Neighborhood Hits	69
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.510695 (rank : 15)	θ value	2.61198e-07 (rank : 23)
Query Neighborhood Hits	200	Target Neighborhood Hits	151	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_MOUSE
NC score	0.508537 (rank : 16)	θ value	1.74796e-11 (rank : 9)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_MOUSE
NC score	0.508451 (rank : 17)	θ value	7.34386e-10 (rank : 14)
Query Neighborhood Hits	200	Target Neighborhood Hits	163	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD4_HUMAN
NC score	0.507535 (rank : 18)	θ value	2.28291e-11 (rank : 10)
Query Neighborhood Hits	200	Target Neighborhood Hits	219	Shared Neighborhood Hits	56
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD1_HUMAN
NC score	0.475028 (rank : 19)	θ value	0.000602161 (rank : 34)
Query Neighborhood Hits	200	Target Neighborhood Hits	367	Shared Neighborhood Hits	71
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.474128 (rank : 20)	θ value	0.00390308 (rank : 40)
Query Neighborhood Hits	200	Target Neighborhood Hits	387	Shared Neighborhood Hits	82
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG7_MOUSE
NC score	0.473030 (rank : 21)	θ value	5.62301e-10 (rank : 13)
Query Neighborhood Hits	200	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.471565 (rank : 22)	θ value	1.06045e-08 (rank : 16)
Query Neighborhood Hits	200	Target Neighborhood Hits	347	Shared Neighborhood Hits	60
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ECT2_MOUSE
NC score	0.447322 (rank : 23)	θ value	0.00035302 (rank : 33)
Query Neighborhood Hits	200	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG6_HUMAN
NC score	0.445263 (rank : 24)	θ value	1.87187e-05 (rank : 28)
Query Neighborhood Hits	200	Target Neighborhood Hits	376	Shared Neighborhood Hits	52
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

DNMBP_HUMAN
NC score	0.436434 (rank : 25)	θ value	6.64225e-11 (rank : 12)
Query Neighborhood Hits	200	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.434408 (rank : 26)	θ value	1.80886e-08 (rank : 17)
Query Neighborhood Hits	200	Target Neighborhood Hits	435	Shared Neighborhood Hits	62
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGA_MOUSE
NC score	0.432963 (rank : 27)	θ value	0.00390308 (rank : 39)
Query Neighborhood Hits	200	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.432186 (rank : 28)	θ value	0.00035302 (rank : 32)
Query Neighborhood Hits	200	Target Neighborhood Hits	187	Shared Neighborhood Hits	56
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
NC score	0.431200 (rank : 29)	θ value	0.0193708 (rank : 52)
Query Neighborhood Hits	200	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG6_MOUSE
NC score	0.428652 (rank : 30)	θ value	3.19293e-05 (rank : 29)
Query Neighborhood Hits	200	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FGD6_MOUSE
NC score	0.428271 (rank : 31)	θ value	0.00020696 (rank : 31)
Query Neighborhood Hits	200	Target Neighborhood Hits	282	Shared Neighborhood Hits	55
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
NC score	0.425930 (rank : 32)	θ value	3.19293e-05 (rank : 30)
Query Neighborhood Hits	200	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ARHG3_HUMAN
NC score	0.383409 (rank : 33)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	200	Target Neighborhood Hits	82	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.382344 (rank : 34)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
NC score	0.381635 (rank : 35)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FGD5_HUMAN
NC score	0.379495 (rank : 36)	θ value	0.00869519 (rank : 46)
Query Neighborhood Hits	200	Target Neighborhood Hits	235	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.373551 (rank : 37)	θ value	0.00665767 (rank : 43)
Query Neighborhood Hits	200	Target Neighborhood Hits	170	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

VAV_MOUSE
NC score	0.371898 (rank : 38)	θ value	1.29631e-06 (rank : 25)
Query Neighborhood Hits	200	Target Neighborhood Hits	430	Shared Neighborhood Hits	56
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.366148 (rank : 39)	θ value	9.92553e-07 (rank : 24)
Query Neighborhood Hits	200	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG8_MOUSE
NC score	0.364694 (rank : 40)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	200	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG5_HUMAN
NC score	0.362819 (rank : 41)	θ value	0.00102713 (rank : 36)
Query Neighborhood Hits	200	Target Neighborhood Hits	172	Shared Neighborhood Hits	57
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FARP2_MOUSE
NC score	0.344046 (rank : 42)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	200	Target Neighborhood Hits	209	Shared Neighborhood Hits	60
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGG_HUMAN
NC score	0.339099 (rank : 43)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	200	Target Neighborhood Hits	129	Shared Neighborhood Hits	54
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

VAV2_MOUSE
NC score	0.338400 (rank : 44)	θ value	0.00509761 (rank : 42)
Query Neighborhood Hits	200	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.333990 (rank : 45)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	200	Target Neighborhood Hits	453	Shared Neighborhood Hits	56
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FARP2_HUMAN
NC score	0.333324 (rank : 46)	θ value	0.00175202 (rank : 38)
Query Neighborhood Hits	200	Target Neighborhood Hits	240	Shared Neighborhood Hits	55
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

VAV3_HUMAN
NC score	0.332256 (rank : 47)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	200	Target Neighborhood Hits	398	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.325168 (rank : 48)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	200	Target Neighborhood Hits	404	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHGG_MOUSE
NC score	0.320766 (rank : 49)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	200	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.314955 (rank : 50)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	53
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.313153 (rank : 51)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	200	Target Neighborhood Hits	214	Shared Neighborhood Hits	58
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_MOUSE
NC score	0.311213 (rank : 52)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	200	Target Neighborhood Hits	228	Shared Neighborhood Hits	55
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FARP1_HUMAN
NC score	0.295291 (rank : 53)	θ value	0.000786445 (rank : 35)
Query Neighborhood Hits	200	Target Neighborhood Hits	241	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

TRIO_HUMAN
NC score	0.279825 (rank : 54)	θ value	2.1121e-49 (rank : 2)
Query Neighborhood Hits	200	Target Neighborhood Hits	1580	Shared Neighborhood Hits	75
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ARHG2_MOUSE
NC score	0.276506 (rank : 55)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	200	Target Neighborhood Hits	120	Shared Neighborhood Hits	49
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ABR_HUMAN
NC score	0.273219 (rank : 56)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

BCR_HUMAN
NC score	0.263056 (rank : 57)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	200	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG1_HUMAN
NC score	0.261485 (rank : 58)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	200	Target Neighborhood Hits	176	Shared Neighborhood Hits	74
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

DUET_HUMAN
NC score	0.261109 (rank : 59)	θ value	1.08474e-45 (rank : 3)
Query Neighborhood Hits	200	Target Neighborhood Hits	1220	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHGB_HUMAN
NC score	0.258357 (rank : 60)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	200	Target Neighborhood Hits	375	Shared Neighborhood Hits	63
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LBC_HUMAN
NC score	0.252845 (rank : 61)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	200	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG2_HUMAN
NC score	0.251252 (rank : 62)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	200	Target Neighborhood Hits	142	Shared Neighborhood Hits	49
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_HUMAN
NC score	0.247577 (rank : 63)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	200	Target Neighborhood Hits	351	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_MOUSE
NC score	0.244966 (rank : 64)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	91
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ITSN2_HUMAN
NC score	0.242833 (rank : 65)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	200	Target Neighborhood Hits	1173	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GNRP_MOUSE
NC score	0.239057 (rank : 66)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	200	Target Neighborhood Hits	191	Shared Neighborhood Hits	51
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGC_MOUSE
NC score	0.235301 (rank : 67)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	200	Target Neighborhood Hits	344	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ITSN2_MOUSE
NC score	0.227017 (rank : 68)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	200	Target Neighborhood Hits	1371	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.220215 (rank : 69)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	200	Target Neighborhood Hits	1757	Shared Neighborhood Hits	84
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.220124 (rank : 70)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	200	Target Neighborhood Hits	1669	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

GNRP_HUMAN
NC score	0.215269 (rank : 71)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	200	Target Neighborhood Hits	239	Shared Neighborhood Hits	52
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RGNEF_MOUSE
NC score	0.212522 (rank : 72)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	200	Target Neighborhood Hits	641	Shared Neighborhood Hits	63
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SOS2_HUMAN
NC score	0.180341 (rank : 73)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	200	Target Neighborhood Hits	193	Shared Neighborhood Hits	36
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.178573 (rank : 74)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	200	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.167517 (rank : 75)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	200	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

OBSCN_HUMAN
NC score	0.165796 (rank : 76)	θ value	4.9032e-22 (rank : 8)
Query Neighborhood Hits	200	Target Neighborhood Hits	1931	Shared Neighborhood Hits	109
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PKHF2_HUMAN
NC score	0.151160 (rank : 77)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	200	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.150954 (rank : 78)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	200	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_HUMAN
NC score	0.149835 (rank : 79)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	200	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.149077 (rank : 80)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	200	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

SPTA2_HUMAN
NC score	0.108061 (rank : 81)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	200	Target Neighborhood Hits	888	Shared Neighborhood Hits	36
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NCF1_HUMAN
NC score	0.107926 (rank : 82)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	200	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ZFY28_HUMAN
NC score	0.100367 (rank : 83)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	200	Target Neighborhood Hits	152	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

SPTA1_MOUSE
NC score	0.100292 (rank : 84)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	200	Target Neighborhood Hits	675	Shared Neighborhood Hits	30
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

OGFR_HUMAN
NC score	0.095373 (rank : 85)	θ value	0.0736092 (rank : 59)
Query Neighborhood Hits	200	Target Neighborhood Hits	1582	Shared Neighborhood Hits	108
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ZFYV9_HUMAN
NC score	0.095072 (rank : 86)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	200	Target Neighborhood Hits	134	Shared Neighborhood Hits	12
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

NCF1_MOUSE
NC score	0.094042 (rank : 87)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	200	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SPTA1_HUMAN
NC score	0.093627 (rank : 88)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	200	Target Neighborhood Hits	748	Shared Neighborhood Hits	32
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SH3K1_HUMAN
NC score	0.092275 (rank : 89)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	200	Target Neighborhood Hits	341	Shared Neighborhood Hits	25
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

EMID2_HUMAN
NC score	0.091606 (rank : 90)	θ value	0.0193708 (rank : 53)
Query Neighborhood Hits	200	Target Neighborhood Hits	226	Shared Neighborhood Hits	42
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

ZFY16_MOUSE
NC score	0.090266 (rank : 91)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	200	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.089180 (rank : 92)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	200	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

SH3K1_MOUSE
NC score	0.088922 (rank : 93)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	200	Target Neighborhood Hits	332	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ZFY16_HUMAN
NC score	0.088461 (rank : 94)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	200	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.087738 (rank : 95)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	200	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

EMID2_MOUSE
NC score	0.086816 (rank : 96)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	200	Target Neighborhood Hits	201	Shared Neighborhood Hits	38
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

CO5A1_MOUSE
NC score	0.085391 (rank : 97)	θ value	0.0148317 (rank : 50)
Query Neighborhood Hits	200	Target Neighborhood Hits	419	Shared Neighborhood Hits	55
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO5A1_HUMAN
NC score	0.085312 (rank : 98)	θ value	0.0148317 (rank : 49)
Query Neighborhood Hits	200	Target Neighborhood Hits	434	Shared Neighborhood Hits	55
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CD2AP_HUMAN
NC score	0.085253 (rank : 99)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	200	Target Neighborhood Hits	315	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.085037 (rank : 100)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	200	Target Neighborhood Hits	336	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

TB182_HUMAN
NC score	0.084629 (rank : 101)	θ value	0.0330416 (rank : 54)
Query Neighborhood Hits	200	Target Neighborhood Hits	414	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

SRBS1_HUMAN
NC score	0.081528 (rank : 102)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	200	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_HUMAN
NC score	0.081326 (rank : 103)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC_HUMAN
NC score	0.081144 (rank : 104)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	200	Target Neighborhood Hits	276	Shared Neighborhood Hits	25
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCF4_MOUSE
NC score	0.080770 (rank : 105)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	200	Target Neighborhood Hits	177	Shared Neighborhood Hits	17
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SPTN5_HUMAN
NC score	0.078252 (rank : 106)	θ value	0.00509761 (rank : 41)
Query Neighborhood Hits	200	Target Neighborhood Hits	674	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

COBA2_MOUSE
NC score	0.077495 (rank : 107)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	200	Target Neighborhood Hits	501	Shared Neighborhood Hits	64
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CO4A3_HUMAN
NC score	0.076714 (rank : 108)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	200	Target Neighborhood Hits	421	Shared Neighborhood Hits	57
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

STAC_MOUSE
NC score	0.076683 (rank : 109)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	200	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

RBNS5_HUMAN
NC score	0.076545 (rank : 110)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

CO1A1_HUMAN
NC score	0.076373 (rank : 111)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	200	Target Neighborhood Hits	475	Shared Neighborhood Hits	57
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO4A4_HUMAN
NC score	0.075686 (rank : 112)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	200	Target Neighborhood Hits	440	Shared Neighborhood Hits	62
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CO2A1_HUMAN
NC score	0.075002 (rank : 113)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	200	Target Neighborhood Hits	486	Shared Neighborhood Hits	66
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO1A1_MOUSE
NC score	0.074867 (rank : 114)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	200	Target Neighborhood Hits	457	Shared Neighborhood Hits	57
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO9A1_MOUSE
NC score	0.074507 (rank : 115)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	200	Target Neighborhood Hits	477	Shared Neighborhood Hits	66
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

NCF2_HUMAN
NC score	0.074360 (rank : 116)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	200	Target Neighborhood Hits	229	Shared Neighborhood Hits	19
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CO9A2_HUMAN
NC score	0.074290 (rank : 117)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	200	Target Neighborhood Hits	261	Shared Neighborhood Hits	46
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

CO5A2_HUMAN
NC score	0.073899 (rank : 118)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	200	Target Neighborhood Hits	760	Shared Neighborhood Hits	79
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

IASPP_MOUSE
NC score	0.073626 (rank : 119)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	200	Target Neighborhood Hits	1024	Shared Neighborhood Hits	91
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

GRAP_HUMAN
NC score	0.073373 (rank : 120)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	21
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CO5A3_HUMAN
NC score	0.072680 (rank : 121)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	200	Target Neighborhood Hits	433	Shared Neighborhood Hits	62
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

COJA1_HUMAN
NC score	0.072557 (rank : 122)	θ value	1.38821 (rank : 104)
Query Neighborhood Hits	200	Target Neighborhood Hits	323	Shared Neighborhood Hits	50
SwissProt Accessions	Q14993, Q00559, Q05850, Q12885, Q13676, Q5JUF0, Q5T424, Q9H572, Q9NPZ2, Q9NQP2	Gene names	COL19A1
Domain Architecture
Description	Collagen alpha-1(XIX) chain precursor (Collagen alpha-1(Y) chain).

CO4A2_MOUSE
NC score	0.072136 (rank : 123)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	200	Target Neighborhood Hits	492	Shared Neighborhood Hits	67
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

COBA2_HUMAN
NC score	0.072045 (rank : 124)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	200	Target Neighborhood Hits	408	Shared Neighborhood Hits	55
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CO2A1_MOUSE
NC score	0.071940 (rank : 125)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	200	Target Neighborhood Hits	483	Shared Neighborhood Hits	63
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

COBA1_HUMAN
NC score	0.071711 (rank : 126)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	200	Target Neighborhood Hits	491	Shared Neighborhood Hits	60
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CO3A1_MOUSE
NC score	0.071627 (rank : 127)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	200	Target Neighborhood Hits	466	Shared Neighborhood Hits	55
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO4A2_HUMAN
NC score	0.071459 (rank : 128)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	200	Target Neighborhood Hits	454	Shared Neighborhood Hits	64
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

SRBS1_MOUSE
NC score	0.071433 (rank : 129)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	200	Target Neighborhood Hits	409	Shared Neighborhood Hits	21
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

RBNS5_MOUSE
NC score	0.071100 (rank : 130)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

CO9A2_MOUSE
NC score	0.070930 (rank : 131)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	200	Target Neighborhood Hits	279	Shared Neighborhood Hits	48
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

COBA1_MOUSE
NC score	0.070802 (rank : 132)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	200	Target Neighborhood Hits	487	Shared Neighborhood Hits	60
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

VINEX_MOUSE
NC score	0.070631 (rank : 133)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

OGFR_MOUSE
NC score	0.070545 (rank : 134)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	200	Target Neighborhood Hits	584	Shared Neighborhood Hits	61
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

HGS_MOUSE
NC score	0.070306 (rank : 135)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	200	Target Neighborhood Hits	589	Shared Neighborhood Hits	29
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

CO1A2_MOUSE
NC score	0.070302 (rank : 136)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	200	Target Neighborhood Hits	388	Shared Neighborhood Hits	57
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

STAM1_HUMAN
NC score	0.070173 (rank : 137)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	200	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP_MOUSE
NC score	0.070145 (rank : 138)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	200	Target Neighborhood Hits	309	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VINEX_HUMAN
NC score	0.070080 (rank : 139)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	200	Target Neighborhood Hits	270	Shared Neighborhood Hits	19
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

HGS_HUMAN
NC score	0.069717 (rank : 140)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	200	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

CO3A1_HUMAN
NC score	0.069599 (rank : 141)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	200	Target Neighborhood Hits	452	Shared Neighborhood Hits	56
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO7A1_HUMAN
NC score	0.069480 (rank : 142)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	200	Target Neighborhood Hits	807	Shared Neighborhood Hits	68
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

CONA1_HUMAN
NC score	0.069449 (rank : 143)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	200	Target Neighborhood Hits	281	Shared Neighborhood Hits	52
SwissProt Accessions	Q86Y22, Q8IVR4, Q9NT93	Gene names	COL23A1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

CO4A6_HUMAN
NC score	0.068700 (rank : 144)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	200	Target Neighborhood Hits	318	Shared Neighborhood Hits	52
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

CO4A1_MOUSE
NC score	0.068690 (rank : 145)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	200	Target Neighborhood Hits	450	Shared Neighborhood Hits	62
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO9A1_HUMAN
NC score	0.068437 (rank : 146)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	200	Target Neighborhood Hits	420	Shared Neighborhood Hits	61
SwissProt Accessions	P20849, Q13699, Q13700, Q5TF52, Q6P467, Q96BM8, Q99225, Q9H151, Q9H152, Q9Y6P2, Q9Y6P3	Gene names	COL9A1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

CO4A1_HUMAN
NC score	0.068373 (rank : 147)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	200	Target Neighborhood Hits	425	Shared Neighborhood Hits	57
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO9A3_HUMAN
NC score	0.067823 (rank : 148)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	200	Target Neighborhood Hits	361	Shared Neighborhood Hits	53
SwissProt Accessions	Q14050, Q13681, Q9H4G9, Q9UPE2	Gene names	COL9A3
Domain Architecture	No domain graphic available
Description	Collagen alpha-3(IX) chain precursor.

STAC3_HUMAN
NC score	0.067647 (rank : 149)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	200	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.067628 (rank : 150)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	200	Target Neighborhood Hits	232	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCK1_HUMAN
NC score	0.067367 (rank : 151)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	200	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAM1_MOUSE
NC score	0.067206 (rank : 152)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	200	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRC8_HUMAN
NC score	0.065857 (rank : 153)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	200	Target Neighborhood Hits	269	Shared Neighborhood Hits	19
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CO1A2_HUMAN
NC score	0.065762 (rank : 154)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	200	Target Neighborhood Hits	329	Shared Neighborhood Hits	49
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

GRB2_HUMAN
NC score	0.065624 (rank : 155)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	200	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

PKHA6_HUMAN
NC score	0.065579 (rank : 156)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	200	Target Neighborhood Hits	556	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GRB2_MOUSE
NC score	0.065494 (rank : 157)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	200	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH3G1_HUMAN
NC score	0.065093 (rank : 158)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

EMID1_MOUSE
NC score	0.064683 (rank : 159)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	200	Target Neighborhood Hits	230	Shared Neighborhood Hits	44
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

SH3G3_MOUSE
NC score	0.064358 (rank : 160)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	200	Target Neighborhood Hits	236	Shared Neighborhood Hits	18
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRC8_MOUSE
NC score	0.063991 (rank : 161)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	200	Target Neighborhood Hits	292	Shared Neighborhood Hits	24
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CONA1_MOUSE
NC score	0.063982 (rank : 162)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	200	Target Neighborhood Hits	254	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K4G2, Q5SUQ0	Gene names	Col23a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXIII) chain.

NCK2_HUMAN
NC score	0.063911 (rank : 163)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	200	Target Neighborhood Hits	310	Shared Neighborhood Hits	21
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

COGA1_HUMAN
NC score	0.063874 (rank : 164)	θ value	1.38821 (rank : 103)
Query Neighborhood Hits	200	Target Neighborhood Hits	345	Shared Neighborhood Hits	50
SwissProt Accessions	Q07092	Gene names	COL16A1
Domain Architecture
Description	Collagen alpha-1(XVI) chain precursor.

COHA1_MOUSE
NC score	0.063724 (rank : 165)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	200	Target Neighborhood Hits	414	Shared Neighborhood Hits	51
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

GRAP2_HUMAN
NC score	0.063465 (rank : 166)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	200	Target Neighborhood Hits	304	Shared Neighborhood Hits	20
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PPIP1_HUMAN
NC score	0.063309 (rank : 167)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	200	Target Neighborhood Hits	389	Shared Neighborhood Hits	21
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BCL9_MOUSE
NC score	0.063249 (rank : 168)	θ value	2.36792 (rank : 119)
Query Neighborhood Hits	200	Target Neighborhood Hits	770	Shared Neighborhood Hits	77
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

SH3G1_MOUSE
NC score	0.063168 (rank : 169)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	200	Target Neighborhood Hits	291	Shared Neighborhood Hits	24
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAM2_MOUSE
NC score	0.062987 (rank : 170)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	200	Target Neighborhood Hits	285	Shared Neighborhood Hits	21
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G3_HUMAN
NC score	0.062982 (rank : 171)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	200	Target Neighborhood Hits	222	Shared Neighborhood Hits	19
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CO4A5_HUMAN
NC score	0.062951 (rank : 172)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	200	Target Neighborhood Hits	383	Shared Neighborhood Hits	57
SwissProt Accessions	P29400, Q16006, Q16126, Q6LD84	Gene names	COL4A5
Domain Architecture
Description	Collagen alpha-5(IV) chain precursor.

HCLS1_MOUSE
NC score	0.062688 (rank : 173)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	200	Target Neighborhood Hits	329	Shared Neighborhood Hits	27
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CRK_MOUSE
NC score	0.062586 (rank : 174)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	200	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI2_HUMAN
NC score	0.062408 (rank : 175)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	200	Target Neighborhood Hits	350	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

FYV1_HUMAN
NC score	0.062342 (rank : 176)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	200	Target Neighborhood Hits	217	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

GRAP2_MOUSE
NC score	0.062338 (rank : 177)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	200	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAM2_HUMAN
NC score	0.061912 (rank : 178)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	200	Target Neighborhood Hits	288	Shared Neighborhood Hits	22
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

TCGAP_HUMAN
NC score	0.061662 (rank : 179)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	200	Target Neighborhood Hits	872	Shared Neighborhood Hits	84
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

CRK_HUMAN
NC score	0.061369 (rank : 180)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	200	Target Neighborhood Hits	308	Shared Neighborhood Hits	21
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ZFY19_HUMAN
NC score	0.061247 (rank : 181)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	200	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

OSTF1_HUMAN
NC score	0.061074 (rank : 182)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	200	Target Neighborhood Hits	466	Shared Neighborhood Hits	22
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SSBP4_HUMAN
NC score	0.060999 (rank : 183)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	200	Target Neighborhood Hits	753	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

OSTF1_MOUSE
NC score	0.060810 (rank : 184)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	200	Target Neighborhood Hits	467	Shared Neighborhood Hits	22
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

HCLS1_HUMAN
NC score	0.060795 (rank : 185)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	200	Target Neighborhood Hits	358	Shared Neighborhood Hits	24
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G2_HUMAN
NC score	0.060778 (rank : 186)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	200	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PPIP1_MOUSE
NC score	0.060123 (rank : 187)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	200	Target Neighborhood Hits	377	Shared Neighborhood Hits	21
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G2_MOUSE
NC score	0.059783 (rank : 188)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	200	Target Neighborhood Hits	319	Shared Neighborhood Hits	21
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NPHP1_MOUSE
NC score	0.058730 (rank : 189)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	200	Target Neighborhood Hits	267	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

BCAR1_HUMAN
NC score	0.058710 (rank : 190)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	200	Target Neighborhood Hits	554	Shared Neighborhood Hits	43
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CPSF6_MOUSE
NC score	0.058632 (rank : 191)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	200	Target Neighborhood Hits	356	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CPSF6_HUMAN
NC score	0.058621 (rank : 192)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	200	Target Neighborhood Hits	359	Shared Neighborhood Hits	29
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

SON_HUMAN
NC score	0.058613 (rank : 193)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	200	Target Neighborhood Hits	1568	Shared Neighborhood Hits	92
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ABI2_MOUSE
NC score	0.058481 (rank : 194)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	200	Target Neighborhood Hits	266	Shared Neighborhood Hits	21
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PRRT3_HUMAN
NC score	0.058472 (rank : 195)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	200	Target Neighborhood Hits	998	Shared Neighborhood Hits	82
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PRPC_HUMAN
NC score	0.057927 (rank : 196)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	200	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

CRKL_HUMAN
NC score	0.057882 (rank : 197)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	200	Target Neighborhood Hits	313	Shared Neighborhood Hits	21
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

FYV1_MOUSE
NC score	0.057290 (rank : 198)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	200	Target Neighborhood Hits	191	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

CRKL_MOUSE
NC score	0.057002 (rank : 199)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	200	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABI1_MOUSE
NC score	0.056927 (rank : 200)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	200	Target Neighborhood Hits	246	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

EMID1_HUMAN
NC score	0.056895 (rank : 201)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	200	Target Neighborhood Hits	215	Shared Neighborhood Hits	40
SwissProt Accessions	Q96A84, Q6ICG1, Q86SS7	Gene names	EMID1, EMU1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

CO6A1_HUMAN
NC score	0.056652 (rank : 202)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	200	Target Neighborhood Hits	264	Shared Neighborhood Hits	45
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

MARCO_MOUSE
NC score	0.056640 (rank : 203)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	200	Target Neighborhood Hits	242	Shared Neighborhood Hits	43
SwissProt Accessions	Q60754	Gene names	Marco
Domain Architecture
Description	Macrophage receptor MARCO (Macrophage receptor with collagenous structure).

ZFY19_MOUSE
NC score	0.056632 (rank : 204)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	200	Target Neighborhood Hits	143	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

COHA1_HUMAN
NC score	0.056545 (rank : 205)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	200	Target Neighborhood Hits	400	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

ZFYV1_HUMAN
NC score	0.056517 (rank : 206)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	200	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

COIA1_MOUSE
NC score	0.056483 (rank : 207)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	200	Target Neighborhood Hits	481	Shared Neighborhood Hits	53
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

SHAN2_MOUSE
NC score	0.056469 (rank : 208)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	200	Target Neighborhood Hits	446	Shared Neighborhood Hits	28
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHAN1_HUMAN
NC score	0.056098 (rank : 209)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	200	Target Neighborhood Hits	1041	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

COFA1_MOUSE
NC score	0.055995 (rank : 210)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	46
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

COAA1_MOUSE
NC score	0.055958 (rank : 211)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	48
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

CN032_HUMAN
NC score	0.055900 (rank : 212)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	200	Target Neighborhood Hits	267	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

ZFYV1_MOUSE
NC score	0.055550 (rank : 213)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	200	Target Neighborhood Hits	153	Shared Neighborhood Hits	12
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

PKHA6_MOUSE
NC score	0.055415 (rank : 214)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	200	Target Neighborhood Hits	591	Shared Neighborhood Hits	58
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CO8A1_HUMAN
NC score	0.055348 (rank : 215)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	200	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

BCAR1_MOUSE
NC score	0.054480 (rank : 216)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	200	Target Neighborhood Hits	438	Shared Neighborhood Hits	37
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EEA1_MOUSE
NC score	0.054232 (rank : 217)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	200	Target Neighborhood Hits	1637	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

CO8A1_MOUSE
NC score	0.053775 (rank : 218)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	200	Target Neighborhood Hits	251	Shared Neighborhood Hits	41
SwissProt Accessions	Q00780, Q9D2V4	Gene names	Col8a1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor.

RGS3_MOUSE
NC score	0.053474 (rank : 219)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	200	Target Neighborhood Hits	1621	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

COFA1_HUMAN
NC score	0.053410 (rank : 220)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	200	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

ABI3_MOUSE
NC score	0.053409 (rank : 221)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DIDO1_HUMAN
NC score	0.053341 (rank : 222)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	200	Target Neighborhood Hits	960	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

COLQ_HUMAN
NC score	0.053336 (rank : 223)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	200	Target Neighborhood Hits	193	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y215, Q6DK18, Q6YH18, Q6YH19, Q6YH20, Q6YH21, Q9NP18, Q9NP19, Q9NP20, Q9NP21, Q9NP22, Q9NP23, Q9NP24, Q9UP88	Gene names	COLQ
Domain Architecture	No domain graphic available
Description	Acetylcholinesterase collagenic tail peptide precursor (AChE Q subunit) (Acetylcholinesterase-associated collagen).

ABI3_HUMAN
NC score	0.053278 (rank : 224)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	200	Target Neighborhood Hits	227	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SPTB2_HUMAN
NC score	0.052896 (rank : 225)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	200	Target Neighborhood Hits	748	Shared Neighborhood Hits	27
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MUC1_HUMAN
NC score	0.052794 (rank : 226)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	200	Target Neighborhood Hits	975	Shared Neighborhood Hits	73
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

CO6A1_MOUSE
NC score	0.052770 (rank : 227)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	200	Target Neighborhood Hits	241	Shared Neighborhood Hits	43
SwissProt Accessions	Q04857	Gene names	Col6a1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

OBSL1_HUMAN
NC score	0.052503 (rank : 228)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	200	Target Neighborhood Hits	354	Shared Neighborhood Hits	7
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

CO6A2_MOUSE
NC score	0.052465 (rank : 229)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	200	Target Neighborhood Hits	260	Shared Neighborhood Hits	43
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

CO6A2_HUMAN
NC score	0.052022 (rank : 230)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	200	Target Neighborhood Hits	249	Shared Neighborhood Hits	43
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

SPTB2_MOUSE
NC score	0.051904 (rank : 231)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	200	Target Neighborhood Hits	770	Shared Neighborhood Hits	29
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CO8A2_HUMAN
NC score	0.050991 (rank : 232)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	200	Target Neighborhood Hits	299	Shared Neighborhood Hits	48
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

PEX13_HUMAN
NC score	0.050842 (rank : 233)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	200	Target Neighborhood Hits	128	Shared Neighborhood Hits	15
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUFY1_MOUSE
NC score	0.050555 (rank : 234)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	200	Target Neighborhood Hits	765	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

PEX13_MOUSE
NC score	0.050554 (rank : 235)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	200	Target Neighborhood Hits	126	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

WDFY1_HUMAN
NC score	0.050504 (rank : 236)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ABI1_HUMAN
NC score	0.050439 (rank : 237)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	200	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

WDFY3_HUMAN
NC score	0.050378 (rank : 238)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	200	Target Neighborhood Hits	348	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

BCL9_HUMAN
NC score	0.050253 (rank : 239)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	200	Target Neighborhood Hits	1008	Shared Neighborhood Hits	78
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

EAF1_HUMAN
NC score	0.050236 (rank : 240)	θ value	0.365318 (rank : 71)
Query Neighborhood Hits	200	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JC9, Q8IW10	Gene names	EAF1
Domain Architecture	No domain graphic available
Description	ELL-associated factor 1.

SPTN4_HUMAN
NC score	0.050233 (rank : 241)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	200	Target Neighborhood Hits	570	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

DBNL_HUMAN
NC score	0.050145 (rank : 242)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	200	Target Neighborhood Hits	244	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SPTN2_HUMAN
NC score	0.050028 (rank : 243)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	200	Target Neighborhood Hits	535	Shared Neighborhood Hits	24
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

COEA1_HUMAN
NC score	0.048188 (rank : 244)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	200	Target Neighborhood Hits	427	Shared Neighborhood Hits	43
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

MAGE1_HUMAN
NC score	0.045762 (rank : 245)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	200	Target Neighborhood Hits	1389	Shared Neighborhood Hits	88
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

EAF1_MOUSE
NC score	0.045657 (rank : 246)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	200	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D4C5	Gene names	Eaf1
Domain Architecture	No domain graphic available
Description	ELL-associated factor 1.

COCA1_HUMAN
NC score	0.045620 (rank : 247)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	200	Target Neighborhood Hits	458	Shared Neighborhood Hits	43
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COCA1_MOUSE
NC score	0.044469 (rank : 248)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	200	Target Neighborhood Hits	467	Shared Neighborhood Hits	44
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

SYNE1_HUMAN
NC score	0.043596 (rank : 249)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	200	Target Neighborhood Hits	1484	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CEL_HUMAN
NC score	0.042152 (rank : 250)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	200	Target Neighborhood Hits	896	Shared Neighborhood Hits	77
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

TAF4_HUMAN
NC score	0.041807 (rank : 251)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	200	Target Neighborhood Hits	687	Shared Neighborhood Hits	37
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

COEA1_MOUSE
NC score	0.040397 (rank : 252)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	200	Target Neighborhood Hits	402	Shared Neighborhood Hits	44
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

DUS8_HUMAN
NC score	0.040348 (rank : 253)	θ value	0.00869519 (rank : 45)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

IRS2_MOUSE
NC score	0.040331 (rank : 254)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	200	Target Neighborhood Hits	248	Shared Neighborhood Hits	17
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

PP1RA_HUMAN
NC score	0.039967 (rank : 255)	θ value	1.38821 (rank : 106)
Query Neighborhood Hits	200	Target Neighborhood Hits	180	Shared Neighborhood Hits	19
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

FCRLA_HUMAN
NC score	0.039238 (rank : 256)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	200	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

LRC50_HUMAN
NC score	0.038083 (rank : 257)	θ value	0.365318 (rank : 72)
Query Neighborhood Hits	200	Target Neighborhood Hits	275	Shared Neighborhood Hits	19
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

PTN9_MOUSE
NC score	0.038062 (rank : 258)	θ value	0.00665767 (rank : 44)
Query Neighborhood Hits	200	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	O35239, Q7TSK0	Gene names	Ptpn9
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

SFPQ_HUMAN
NC score	0.037622 (rank : 259)	θ value	0.0431538 (rank : 56)
Query Neighborhood Hits	200	Target Neighborhood Hits	986	Shared Neighborhood Hits	35
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

PTN9_HUMAN
NC score	0.036596 (rank : 260)	θ value	0.0148317 (rank : 51)
Query Neighborhood Hits	200	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	P43378	Gene names	PTPN9
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase-MEG2).

MYLK2_HUMAN
NC score	0.036435 (rank : 261)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	200	Target Neighborhood Hits	920	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

CSPG5_MOUSE
NC score	0.036196 (rank : 262)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	200	Target Neighborhood Hits	211	Shared Neighborhood Hits	17
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

SYN1_MOUSE
NC score	0.035529 (rank : 263)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	200	Target Neighborhood Hits	363	Shared Neighborhood Hits	19
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

MLL2_HUMAN
NC score	0.035023 (rank : 264)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	200	Target Neighborhood Hits	1788	Shared Neighborhood Hits	90
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PP1RA_MOUSE
NC score	0.034227 (rank : 265)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	200	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

WBP11_MOUSE
NC score	0.033927 (rank : 266)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	200	Target Neighborhood Hits	362	Shared Neighborhood Hits	23
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

CNOT3_MOUSE
NC score	0.032560 (rank : 267)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	200	Target Neighborhood Hits	504	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

ACBD4_HUMAN
NC score	0.032448 (rank : 268)	θ value	1.81305 (rank : 109)
Query Neighborhood Hits	200	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NC06, Q8IUT1, Q9H8Q4	Gene names	ACBD4
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 4.

RP1L1_HUMAN
NC score	0.032221 (rank : 269)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	200	Target Neighborhood Hits	1072	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

IRS2_HUMAN
NC score	0.032074 (rank : 270)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	200	Target Neighborhood Hits	262	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

SRRM2_HUMAN
NC score	0.031827 (rank : 271)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	200	Target Neighborhood Hits	1296	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

WDR33_HUMAN
NC score	0.031637 (rank : 272)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	200	Target Neighborhood Hits	638	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

THYG_MOUSE
NC score	0.030390 (rank : 273)	θ value	0.0330416 (rank : 55)
Query Neighborhood Hits	200	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

CSKI2_HUMAN
NC score	0.029898 (rank : 274)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	200	Target Neighborhood Hits	747	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NOL1_HUMAN
NC score	0.028079 (rank : 275)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	200	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

GGA3_MOUSE
NC score	0.027647 (rank : 276)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	200	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

FRAT1_MOUSE
NC score	0.026715 (rank : 277)	θ value	1.81305 (rank : 112)
Query Neighborhood Hits	200	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P70339	Gene names	Frat1
Domain Architecture
Description	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas) (Frat-1).

CSKI1_MOUSE
NC score	0.026069 (rank : 278)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	200	Target Neighborhood Hits	1031	Shared Neighborhood Hits	53
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ULK1_HUMAN
NC score	0.026026 (rank : 279)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	200	Target Neighborhood Hits	1121	Shared Neighborhood Hits	52
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

NUMA1_HUMAN
NC score	0.025169 (rank : 280)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	200	Target Neighborhood Hits	1523	Shared Neighborhood Hits	30
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

GSCR1_HUMAN
NC score	0.025098 (rank : 281)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	200	Target Neighborhood Hits	674	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

AKAP9_HUMAN
NC score	0.023894 (rank : 282)	θ value	1.81305 (rank : 110)
Query Neighborhood Hits	200	Target Neighborhood Hits	1710	Shared Neighborhood Hits	35
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

CSKI2_MOUSE
NC score	0.023867 (rank : 283)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	200	Target Neighborhood Hits	812	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

FOXO4_HUMAN
NC score	0.023756 (rank : 284)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	200	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

SRBP1_HUMAN
NC score	0.023476 (rank : 285)	θ value	1.38821 (rank : 107)
Query Neighborhood Hits	200	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAVS_HUMAN
NC score	0.023446 (rank : 286)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	200	Target Neighborhood Hits	271	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

GNAS1_MOUSE
NC score	0.022919 (rank : 287)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	200	Target Neighborhood Hits	651	Shared Neighborhood Hits	57
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

CDAN1_HUMAN
NC score	0.022871 (rank : 288)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	200	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWY9, Q7Z7L5, Q969N3	Gene names	CDAN1
Domain Architecture	No domain graphic available
Description	Codanin-1.

PERQ1_MOUSE
NC score	0.022575 (rank : 289)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	200	Target Neighborhood Hits	215	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

HSF1_HUMAN
NC score	0.022124 (rank : 290)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	200	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

CNOT3_HUMAN
NC score	0.022001 (rank : 291)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	200	Target Neighborhood Hits	425	Shared Neighborhood Hits	14
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

PHC1_MOUSE
NC score	0.021895 (rank : 292)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	200	Target Neighborhood Hits	205	Shared Neighborhood Hits	9
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

ZN598_HUMAN
NC score	0.021894 (rank : 293)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	200	Target Neighborhood Hits	339	Shared Neighborhood Hits	15
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

HAIR_MOUSE
NC score	0.021464 (rank : 294)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	200	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

GMIP_MOUSE
NC score	0.021404 (rank : 295)	θ value	1.38821 (rank : 105)
Query Neighborhood Hits	200	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

SNIP_HUMAN
NC score	0.021323 (rank : 296)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	200	Target Neighborhood Hits	313	Shared Neighborhood Hits	23
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

FOXC1_HUMAN
NC score	0.021128 (rank : 297)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	200	Target Neighborhood Hits	208	Shared Neighborhood Hits	10
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

MY18B_HUMAN
NC score	0.021000 (rank : 298)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	200	Target Neighborhood Hits	1299	Shared Neighborhood Hits	64
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

K0317_MOUSE
NC score	0.020897 (rank : 299)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	200	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

CNTRB_HUMAN
NC score	0.020637 (rank : 300)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	200	Target Neighborhood Hits	690	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

DAXX_MOUSE
NC score	0.020597 (rank : 301)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	200	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

FOXO4_MOUSE
NC score	0.020187 (rank : 302)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	200	Target Neighborhood Hits	168	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

K0317_HUMAN
NC score	0.019568 (rank : 303)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	200	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

DAXX_HUMAN
NC score	0.019351 (rank : 304)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	200	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

PLEC1_HUMAN
NC score	0.019191 (rank : 305)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	200	Target Neighborhood Hits	1326	Shared Neighborhood Hits	27
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

FOXC1_MOUSE
NC score	0.019100 (rank : 306)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	200	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

ERF_HUMAN
NC score	0.018989 (rank : 307)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	200	Target Neighborhood Hits	162	Shared Neighborhood Hits	17
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

UBP42_HUMAN
NC score	0.018145 (rank : 308)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	200	Target Neighborhood Hits	445	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

IRX1_HUMAN
NC score	0.017967 (rank : 309)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	200	Target Neighborhood Hits	285	Shared Neighborhood Hits	8
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

CABL1_HUMAN
NC score	0.017491 (rank : 310)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	200	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

TACC3_HUMAN
NC score	0.016956 (rank : 311)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	200	Target Neighborhood Hits	779	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

MLL4_HUMAN
NC score	0.016788 (rank : 312)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	200	Target Neighborhood Hits	722	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

CP250_HUMAN
NC score	0.016757 (rank : 313)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	200	Target Neighborhood Hits	1805	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

MUC7_HUMAN
NC score	0.016707 (rank : 314)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	200	Target Neighborhood Hits	538	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PHAR2_HUMAN
NC score	0.015151 (rank : 315)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	200	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

TTC7A_MOUSE
NC score	0.014983 (rank : 316)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	200	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BGB2, Q80XT5	Gene names	Ttc7a, Ttc7
Domain Architecture
Description	Tetratricopeptide repeat protein 7A (TPR repeat protein 7).

SYNJ1_HUMAN
NC score	0.014804 (rank : 317)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	200	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

HCN2_HUMAN
NC score	0.014707 (rank : 318)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	200	Target Neighborhood Hits	369	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

MK15_MOUSE
NC score	0.014424 (rank : 319)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	200	Target Neighborhood Hits	843	Shared Neighborhood Hits	9
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

CUTL1_HUMAN
NC score	0.013790 (rank : 320)	θ value	1.81305 (rank : 111)
Query Neighborhood Hits	200	Target Neighborhood Hits	1574	Shared Neighborhood Hits	34
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

ZSWM5_MOUSE
NC score	0.013446 (rank : 321)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	200	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q80TC6	Gene names	Zswim5, Kiaa1511
Domain Architecture	No domain graphic available
Description	Zinc finger SWIM domain-containing protein 5.

IRX1_MOUSE
NC score	0.012919 (rank : 322)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	200	Target Neighborhood Hits	269	Shared Neighborhood Hits	3
SwissProt Accessions	P81068, O55120, Q9JLL6	Gene names	Irx1, Irxa1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

ESPL1_HUMAN
NC score	0.012289 (rank : 323)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	200	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q14674	Gene names	ESPL1, ESP1, KIAA0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

KCNN3_HUMAN
NC score	0.012156 (rank : 324)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	200	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

PEPL_HUMAN
NC score	0.012140 (rank : 325)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	200	Target Neighborhood Hits	1141	Shared Neighborhood Hits	23
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

K1849_HUMAN
NC score	0.011923 (rank : 326)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	200	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

TNFC_MOUSE
NC score	0.011825 (rank : 327)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	200	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41155	Gene names	Ltb, Tnfc, Tnfsf3
Domain Architecture
Description	Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3).

CCD96_HUMAN
NC score	0.011408 (rank : 328)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	200	Target Neighborhood Hits	595	Shared Neighborhood Hits	20
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

DNM3A_HUMAN
NC score	0.011269 (rank : 329)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	200	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

TRI47_HUMAN
NC score	0.011210 (rank : 330)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	200	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

B3A3_MOUSE
NC score	0.010899 (rank : 331)	θ value	2.36792 (rank : 118)
Query Neighborhood Hits	200	Target Neighborhood Hits	112	Shared Neighborhood Hits	7
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

KIF12_MOUSE
NC score	0.010515 (rank : 332)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	200	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2Z8, O35061	Gene names	Kif12
Domain Architecture
Description	Kinesin-like protein KIF12.

RP3A_HUMAN
NC score	0.010359 (rank : 333)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	200	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

NU107_MOUSE
NC score	0.010304 (rank : 334)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	200	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BH74, Q99KH5	Gene names	Nup107
Domain Architecture
Description	Nuclear pore complex protein Nup107 (Nucleoporin Nup107) (107 kDa nucleoporin).

K1C15_HUMAN
NC score	0.008870 (rank : 335)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	200	Target Neighborhood Hits	367	Shared Neighborhood Hits	10
SwissProt Accessions	P19012, Q53XV8, Q9BUG4	Gene names	KRT15, KRTB
Domain Architecture
Description	Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15).

SUSD4_MOUSE
NC score	0.007803 (rank : 336)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	200	Target Neighborhood Hits	122	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

PP16B_MOUSE
NC score	0.006127 (rank : 337)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	200	Target Neighborhood Hits	302	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

CSTF2_MOUSE
NC score	0.005257 (rank : 338)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	200	Target Neighborhood Hits	255	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BIQ5, Q8K1Y6, Q9ERC2	Gene names	Cstf2
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

SALL3_HUMAN
NC score	0.004677 (rank : 339)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	200	Target Neighborhood Hits	1066	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TBX1_MOUSE
NC score	0.004525 (rank : 340)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	200	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	P70323, Q60706, Q99MP0, Q99P22	Gene names	Tbx1
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX1 (T-box protein 1) (Testis-specific T- box protein).

CAC1C_MOUSE
NC score	0.002333 (rank : 341)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	200	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

PCDH8_HUMAN
NC score	0.001053 (rank : 342)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	200	Target Neighborhood Hits	164	Shared Neighborhood Hits	2
SwissProt Accessions	O95206, Q8IYE9, Q96SF1	Gene names	PCDH8
Domain Architecture
Description	Protocadherin-8 precursor (Arcadlin).

O2T34_HUMAN
NC score	-0.002584 (rank : 343)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	200	Target Neighborhood Hits	863	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGX1, Q6IEY5, Q96R31	Gene names	OR2T34
Domain Architecture	No domain graphic available
Description	Olfactory receptor 2T34 (Olfactory receptor OR1-63).

OR2T3_HUMAN
NC score	-0.002621 (rank : 344)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	200	Target Neighborhood Hits	868	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NH03	Gene names	OR2T3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 2T3.

ZBT7A_HUMAN
NC score	-0.004915 (rank : 345)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	200	Target Neighborhood Hits	823	Shared Neighborhood Hits	8
SwissProt Accessions	O95365, O00456	Gene names	ZBTB7A, FBI1, LRF, ZBTB7
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 7A (Leukemia/lymphoma- related factor) (Factor that binds to inducer of short transcripts protein 1) (Factor binding IST protein 1) (FBI-1) (HIV-1 1st-binding protein 1) (TTF-I-interacting peptide 21) (TIP21).