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Network neighborhood for query Sequence : NCF2_HUMAN

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NCF2_HUMAN
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NCF2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	229	Target Neighborhood Hits	229	Shared Neighborhood Hits	229
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CD2AP_HUMAN
θ value	1.9326e-10 (rank : 2)	NC score	0.735409 (rank : 2)
Query Neighborhood Hits	229	Target Neighborhood Hits	315	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DNMBP_HUMAN
θ value	5.62301e-10 (rank : 3)	NC score	0.605944 (rank : 23)
Query Neighborhood Hits	229	Target Neighborhood Hits	413	Shared Neighborhood Hits	181
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CD2AP_MOUSE
θ value	2.79066e-09 (rank : 4)	NC score	0.731709 (rank : 3)
Query Neighborhood Hits	229	Target Neighborhood Hits	336	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ITSN1_MOUSE
θ value	2.79066e-09 (rank : 5)	NC score	0.448386 (rank : 74)
Query Neighborhood Hits	229	Target Neighborhood Hits	1669	Shared Neighborhood Hits	194
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VINEX_MOUSE
θ value	4.76016e-09 (rank : 6)	NC score	0.709833 (rank : 4)
Query Neighborhood Hits	229	Target Neighborhood Hits	286	Shared Neighborhood Hits	182
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ITSN1_HUMAN
θ value	6.21693e-09 (rank : 7)	NC score	0.446640 (rank : 76)
Query Neighborhood Hits	229	Target Neighborhood Hits	1757	Shared Neighborhood Hits	195
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VINEX_HUMAN
θ value	3.08544e-08 (rank : 8)	NC score	0.706599 (rank : 6)
Query Neighborhood Hits	229	Target Neighborhood Hits	270	Shared Neighborhood Hits	178
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

DNMBP_MOUSE
θ value	6.87365e-08 (rank : 9)	NC score	0.588885 (rank : 32)
Query Neighborhood Hits	229	Target Neighborhood Hits	435	Shared Neighborhood Hits	179
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_HUMAN
θ value	6.87365e-08 (rank : 10)	NC score	0.476249 (rank : 67)
Query Neighborhood Hits	229	Target Neighborhood Hits	1173	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NCF4_MOUSE
θ value	6.87365e-08 (rank : 11)	NC score	0.661931 (rank : 10)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	136
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC3_HUMAN
θ value	8.97725e-08 (rank : 12)	NC score	0.584149 (rank : 35)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	141
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF4_HUMAN
θ value	1.17247e-07 (rank : 13)	NC score	0.649167 (rank : 11)
Query Neighborhood Hits	229	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3K1_MOUSE
θ value	1.53129e-07 (rank : 14)	NC score	0.707221 (rank : 5)
Query Neighborhood Hits	229	Target Neighborhood Hits	332	Shared Neighborhood Hits	173
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAC3_MOUSE
θ value	3.41135e-07 (rank : 15)	NC score	0.583309 (rank : 36)
Query Neighborhood Hits	229	Target Neighborhood Hits	232	Shared Neighborhood Hits	141
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ITSN2_MOUSE
θ value	9.92553e-07 (rank : 16)	NC score	0.453293 (rank : 71)
Query Neighborhood Hits	229	Target Neighborhood Hits	1371	Shared Neighborhood Hits	188
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SRBS1_HUMAN
θ value	1.29631e-06 (rank : 17)	NC score	0.668850 (rank : 9)
Query Neighborhood Hits	229	Target Neighborhood Hits	396	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

OSTF1_MOUSE
θ value	2.88788e-06 (rank : 18)	NC score	0.485877 (rank : 64)
Query Neighborhood Hits	229	Target Neighborhood Hits	467	Shared Neighborhood Hits	174
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PPIP1_MOUSE
θ value	6.43352e-06 (rank : 19)	NC score	0.570485 (rank : 42)
Query Neighborhood Hits	229	Target Neighborhood Hits	377	Shared Neighborhood Hits	176
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3K1_HUMAN
θ value	6.43352e-06 (rank : 20)	NC score	0.703743 (rank : 7)
Query Neighborhood Hits	229	Target Neighborhood Hits	341	Shared Neighborhood Hits	172
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRBS1_MOUSE
θ value	6.43352e-06 (rank : 21)	NC score	0.674696 (rank : 8)
Query Neighborhood Hits	229	Target Neighborhood Hits	409	Shared Neighborhood Hits	180
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_MOUSE
θ value	8.40245e-06 (rank : 22)	NC score	0.606046 (rank : 22)
Query Neighborhood Hits	229	Target Neighborhood Hits	273	Shared Neighborhood Hits	167
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PPIP1_HUMAN
θ value	1.09739e-05 (rank : 23)	NC score	0.576535 (rank : 39)
Query Neighborhood Hits	229	Target Neighborhood Hits	389	Shared Neighborhood Hits	177
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM1_HUMAN
θ value	1.09739e-05 (rank : 24)	NC score	0.604974 (rank : 24)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	169
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
θ value	1.87187e-05 (rank : 25)	NC score	0.624648 (rank : 13)
Query Neighborhood Hits	229	Target Neighborhood Hits	276	Shared Neighborhood Hits	163
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP_HUMAN
θ value	2.44474e-05 (rank : 26)	NC score	0.567283 (rank : 43)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

STAM2_MOUSE
θ value	2.44474e-05 (rank : 27)	NC score	0.599787 (rank : 25)
Query Neighborhood Hits	229	Target Neighborhood Hits	285	Shared Neighborhood Hits	167
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G1_MOUSE
θ value	3.19293e-05 (rank : 28)	NC score	0.585444 (rank : 34)
Query Neighborhood Hits	229	Target Neighborhood Hits	291	Shared Neighborhood Hits	161
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

OSTF1_HUMAN
θ value	4.1701e-05 (rank : 29)	NC score	0.494488 (rank : 62)
Query Neighborhood Hits	229	Target Neighborhood Hits	466	Shared Neighborhood Hits	175
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G1_HUMAN
θ value	4.1701e-05 (rank : 30)	NC score	0.582431 (rank : 37)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	163
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAC_MOUSE
θ value	4.1701e-05 (rank : 31)	NC score	0.607995 (rank : 20)
Query Neighborhood Hits	229	Target Neighborhood Hits	268	Shared Neighborhood Hits	162
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI2_HUMAN
θ value	5.44631e-05 (rank : 32)	NC score	0.623787 (rank : 15)
Query Neighborhood Hits	229	Target Neighborhood Hits	350	Shared Neighborhood Hits	172
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	5.44631e-05 (rank : 33)	NC score	0.630742 (rank : 12)
Query Neighborhood Hits	229	Target Neighborhood Hits	266	Shared Neighborhood Hits	172
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_MOUSE
θ value	5.44631e-05 (rank : 34)	NC score	0.623903 (rank : 14)
Query Neighborhood Hits	229	Target Neighborhood Hits	329	Shared Neighborhood Hits	154
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
θ value	5.44631e-05 (rank : 35)	NC score	0.623060 (rank : 16)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	161
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_HUMAN
θ value	5.44631e-05 (rank : 36)	NC score	0.586516 (rank : 33)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	166
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI1_MOUSE
θ value	7.1131e-05 (rank : 37)	NC score	0.618135 (rank : 18)
Query Neighborhood Hits	229	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SRC8_MOUSE
θ value	7.1131e-05 (rank : 38)	NC score	0.616737 (rank : 19)
Query Neighborhood Hits	229	Target Neighborhood Hits	292	Shared Neighborhood Hits	160
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SH3G3_MOUSE
θ value	9.29e-05 (rank : 39)	NC score	0.607648 (rank : 21)
Query Neighborhood Hits	229	Target Neighborhood Hits	236	Shared Neighborhood Hits	167
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_HUMAN
θ value	0.000121331 (rank : 40)	NC score	0.596934 (rank : 26)
Query Neighborhood Hits	229	Target Neighborhood Hits	257	Shared Neighborhood Hits	165
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRB2_MOUSE
θ value	0.000121331 (rank : 41)	NC score	0.595263 (rank : 30)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	179
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCK_MOUSE
θ value	0.000121331 (rank : 42)	NC score	0.159417 (rank : 190)
Query Neighborhood Hits	229	Target Neighborhood Hits	1029	Shared Neighborhood Hits	156
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ES8L2_HUMAN
θ value	0.000158464 (rank : 43)	NC score	0.298028 (rank : 117)
Query Neighborhood Hits	229	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	0.000158464 (rank : 44)	NC score	0.297724 (rank : 118)
Query Neighborhood Hits	229	Target Neighborhood Hits	169	Shared Neighborhood Hits	106
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

GRB2_HUMAN
θ value	0.000158464 (rank : 45)	NC score	0.595698 (rank : 28)
Query Neighborhood Hits	229	Target Neighborhood Hits	310	Shared Neighborhood Hits	179
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH3G3_HUMAN
θ value	0.000158464 (rank : 46)	NC score	0.595677 (rank : 29)
Query Neighborhood Hits	229	Target Neighborhood Hits	222	Shared Neighborhood Hits	159
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SPTA1_HUMAN
θ value	0.000158464 (rank : 47)	NC score	0.257292 (rank : 129)
Query Neighborhood Hits	229	Target Neighborhood Hits	748	Shared Neighborhood Hits	151
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TTC6_HUMAN
θ value	0.000158464 (rank : 48)	NC score	0.131843 (rank : 219)
Query Neighborhood Hits	229	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q86TZ1, Q96CE6	Gene names	TTC6
Domain Architecture
Description	Tetratricopeptide repeat protein 6 (TPR repeat protein 6).

NCK2_HUMAN
θ value	0.00020696 (rank : 49)	NC score	0.566839 (rank : 44)
Query Neighborhood Hits	229	Target Neighborhood Hits	310	Shared Neighborhood Hits	167
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SH3G2_HUMAN
θ value	0.00020696 (rank : 50)	NC score	0.595711 (rank : 27)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CRKL_HUMAN
θ value	0.000270298 (rank : 51)	NC score	0.549321 (rank : 48)
Query Neighborhood Hits	229	Target Neighborhood Hits	313	Shared Neighborhood Hits	170
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SH3G2_MOUSE
θ value	0.000270298 (rank : 52)	NC score	0.593526 (rank : 31)
Query Neighborhood Hits	229	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GRAP2_HUMAN
θ value	0.00035302 (rank : 53)	NC score	0.575484 (rank : 40)
Query Neighborhood Hits	229	Target Neighborhood Hits	304	Shared Neighborhood Hits	178
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRK_HUMAN
θ value	0.000461057 (rank : 54)	NC score	0.538478 (rank : 52)
Query Neighborhood Hits	229	Target Neighborhood Hits	308	Shared Neighborhood Hits	171
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.000461057 (rank : 55)	NC score	0.541778 (rank : 50)
Query Neighborhood Hits	229	Target Neighborhood Hits	314	Shared Neighborhood Hits	170
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_MOUSE
θ value	0.000461057 (rank : 56)	NC score	0.581729 (rank : 38)
Query Neighborhood Hits	229	Target Neighborhood Hits	297	Shared Neighborhood Hits	179
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CRKL_MOUSE
θ value	0.000602161 (rank : 57)	NC score	0.539777 (rank : 51)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

MYO1E_HUMAN
θ value	0.000602161 (rank : 58)	NC score	0.257181 (rank : 130)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	163
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

HCLS1_HUMAN
θ value	0.000786445 (rank : 59)	NC score	0.618350 (rank : 17)
Query Neighborhood Hits	229	Target Neighborhood Hits	358	Shared Neighborhood Hits	153
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

DDEF2_HUMAN
θ value	0.00102713 (rank : 60)	NC score	0.276687 (rank : 122)
Query Neighborhood Hits	229	Target Neighborhood Hits	599	Shared Neighborhood Hits	141
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.00102713 (rank : 61)	NC score	0.280089 (rank : 121)
Query Neighborhood Hits	229	Target Neighborhood Hits	625	Shared Neighborhood Hits	138
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP_MOUSE
θ value	0.00102713 (rank : 62)	NC score	0.561758 (rank : 45)
Query Neighborhood Hits	229	Target Neighborhood Hits	309	Shared Neighborhood Hits	180
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRGP2_HUMAN
θ value	0.00102713 (rank : 63)	NC score	0.325898 (rank : 107)
Query Neighborhood Hits	229	Target Neighborhood Hits	331	Shared Neighborhood Hits	136
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	0.00102713 (rank : 64)	NC score	0.329654 (rank : 105)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	137
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

NPHP1_HUMAN
θ value	0.00134147 (rank : 65)	NC score	0.448677 (rank : 73)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	140
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

VAV2_HUMAN
θ value	0.00175202 (rank : 66)	NC score	0.446434 (rank : 78)
Query Neighborhood Hits	229	Target Neighborhood Hits	453	Shared Neighborhood Hits	161
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.00175202 (rank : 67)	NC score	0.446562 (rank : 77)
Query Neighborhood Hits	229	Target Neighborhood Hits	456	Shared Neighborhood Hits	161
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

LYN_HUMAN
θ value	0.00228821 (rank : 68)	NC score	0.146849 (rank : 205)
Query Neighborhood Hits	229	Target Neighborhood Hits	1022	Shared Neighborhood Hits	140
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PACN2_MOUSE
θ value	0.00228821 (rank : 69)	NC score	0.505650 (rank : 58)
Query Neighborhood Hits	229	Target Neighborhood Hits	382	Shared Neighborhood Hits	173
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG2_HUMAN
θ value	0.00228821 (rank : 70)	NC score	0.381292 (rank : 98)
Query Neighborhood Hits	229	Target Neighborhood Hits	280	Shared Neighborhood Hits	144
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

AHI1_HUMAN
θ value	0.00298849 (rank : 71)	NC score	0.425958 (rank : 82)
Query Neighborhood Hits	229	Target Neighborhood Hits	537	Shared Neighborhood Hits	174
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG7_HUMAN
θ value	0.00298849 (rank : 72)	NC score	0.534481 (rank : 54)
Query Neighborhood Hits	229	Target Neighborhood Hits	347	Shared Neighborhood Hits	177
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

LYN_MOUSE
θ value	0.00298849 (rank : 73)	NC score	0.145563 (rank : 207)
Query Neighborhood Hits	229	Target Neighborhood Hits	1023	Shared Neighborhood Hits	137
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NCK1_HUMAN
θ value	0.00298849 (rank : 74)	NC score	0.572134 (rank : 41)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	178
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NEBU_HUMAN
θ value	0.00298849 (rank : 75)	NC score	0.394363 (rank : 91)
Query Neighborhood Hits	229	Target Neighborhood Hits	420	Shared Neighborhood Hits	153
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

AHI1_MOUSE
θ value	0.00390308 (rank : 76)	NC score	0.426957 (rank : 81)
Query Neighborhood Hits	229	Target Neighborhood Hits	496	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_MOUSE
θ value	0.00390308 (rank : 77)	NC score	0.524227 (rank : 56)
Query Neighborhood Hits	229	Target Neighborhood Hits	394	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

EFS_MOUSE
θ value	0.00390308 (rank : 78)	NC score	0.417971 (rank : 84)
Query Neighborhood Hits	229	Target Neighborhood Hits	389	Shared Neighborhood Hits	137
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PACN2_HUMAN
θ value	0.00390308 (rank : 79)	NC score	0.502364 (rank : 59)
Query Neighborhood Hits	229	Target Neighborhood Hits	339	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RHG04_HUMAN
θ value	0.00390308 (rank : 80)	NC score	0.361845 (rank : 101)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SPTA1_MOUSE
θ value	0.00390308 (rank : 81)	NC score	0.255935 (rank : 132)
Query Neighborhood Hits	229	Target Neighborhood Hits	675	Shared Neighborhood Hits	145
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VAV_HUMAN
θ value	0.00390308 (rank : 82)	NC score	0.469355 (rank : 69)
Query Neighborhood Hits	229	Target Neighborhood Hits	452	Shared Neighborhood Hits	167
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	0.00390308 (rank : 83)	NC score	0.470718 (rank : 68)
Query Neighborhood Hits	229	Target Neighborhood Hits	430	Shared Neighborhood Hits	171
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

LASP1_HUMAN
θ value	0.00509761 (rank : 84)	NC score	0.483487 (rank : 65)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	151
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00509761 (rank : 85)	NC score	0.480040 (rank : 66)
Query Neighborhood Hits	229	Target Neighborhood Hits	297	Shared Neighborhood Hits	150
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MYO1F_HUMAN
θ value	0.00509761 (rank : 86)	NC score	0.263433 (rank : 127)
Query Neighborhood Hits	229	Target Neighborhood Hits	275	Shared Neighborhood Hits	166
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	0.00509761 (rank : 87)	NC score	0.263787 (rank : 126)
Query Neighborhood Hits	229	Target Neighborhood Hits	262	Shared Neighborhood Hits	166
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PACN1_HUMAN
θ value	0.00509761 (rank : 88)	NC score	0.497542 (rank : 61)
Query Neighborhood Hits	229	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.00509761 (rank : 89)	NC score	0.498442 (rank : 60)
Query Neighborhood Hits	229	Target Neighborhood Hits	283	Shared Neighborhood Hits	167
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ARHG7_MOUSE
θ value	0.00665767 (rank : 90)	NC score	0.543779 (rank : 49)
Query Neighborhood Hits	229	Target Neighborhood Hits	396	Shared Neighborhood Hits	183
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

M3K9_HUMAN
θ value	0.00665767 (rank : 91)	NC score	0.159414 (rank : 191)
Query Neighborhood Hits	229	Target Neighborhood Hits	1123	Shared Neighborhood Hits	157
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CASL_MOUSE
θ value	0.00869519 (rank : 92)	NC score	0.386629 (rank : 95)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	130
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

M3K11_HUMAN
θ value	0.00869519 (rank : 93)	NC score	0.162461 (rank : 187)
Query Neighborhood Hits	229	Target Neighborhood Hits	1136	Shared Neighborhood Hits	161
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RUSC1_HUMAN
θ value	0.00869519 (rank : 94)	NC score	0.386802 (rank : 94)
Query Neighborhood Hits	229	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SPTA2_HUMAN
θ value	0.00869519 (rank : 95)	NC score	0.269632 (rank : 124)
Query Neighborhood Hits	229	Target Neighborhood Hits	888	Shared Neighborhood Hits	161
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

RUSC2_HUMAN
θ value	0.0113563 (rank : 96)	NC score	0.213482 (rank : 150)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ARHG6_HUMAN
θ value	0.0148317 (rank : 97)	NC score	0.514316 (rank : 57)
Query Neighborhood Hits	229	Target Neighborhood Hits	376	Shared Neighborhood Hits	166
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ES8L3_HUMAN
θ value	0.0148317 (rank : 98)	NC score	0.329080 (rank : 106)
Query Neighborhood Hits	229	Target Neighborhood Hits	206	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3K10_HUMAN
θ value	0.0148317 (rank : 99)	NC score	0.141553 (rank : 210)
Query Neighborhood Hits	229	Target Neighborhood Hits	1071	Shared Neighborhood Hits	138
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3KL4_HUMAN
θ value	0.0148317 (rank : 100)	NC score	0.176386 (rank : 172)
Query Neighborhood Hits	229	Target Neighborhood Hits	1087	Shared Neighborhood Hits	157
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

RUSC2_MOUSE
θ value	0.0148317 (rank : 101)	NC score	0.196307 (rank : 159)
Query Neighborhood Hits	229	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ABI3_MOUSE
θ value	0.0193708 (rank : 102)	NC score	0.538410 (rank : 53)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CASL_HUMAN
θ value	0.0193708 (rank : 103)	NC score	0.383193 (rank : 97)
Query Neighborhood Hits	229	Target Neighborhood Hits	259	Shared Neighborhood Hits	127
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DDEF1_MOUSE
θ value	0.0193708 (rank : 104)	NC score	0.294602 (rank : 119)
Query Neighborhood Hits	229	Target Neighborhood Hits	592	Shared Neighborhood Hits	133
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DNJC7_HUMAN
θ value	0.0193708 (rank : 105)	NC score	0.060047 (rank : 376)
Query Neighborhood Hits	229	Target Neighborhood Hits	212	Shared Neighborhood Hits	17
SwissProt Accessions	Q99615	Gene names	DNAJC7, TPR2, TTC2
Domain Architecture
Description	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2).

HCK_HUMAN
θ value	0.0193708 (rank : 106)	NC score	0.155923 (rank : 196)
Query Neighborhood Hits	229	Target Neighborhood Hits	1035	Shared Neighborhood Hits	157
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

INVO_MOUSE
θ value	0.0193708 (rank : 107)	NC score	0.064546 (rank : 365)
Query Neighborhood Hits	229	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

NCF1_MOUSE
θ value	0.0193708 (rank : 108)	NC score	0.557026 (rank : 47)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	149
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ABI3_HUMAN
θ value	0.0252991 (rank : 109)	NC score	0.534306 (rank : 55)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

RUSC1_MOUSE
θ value	0.0252991 (rank : 110)	NC score	0.364182 (rank : 100)
Query Neighborhood Hits	229	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SHAN1_HUMAN
θ value	0.0330416 (rank : 111)	NC score	0.171335 (rank : 176)
Query Neighborhood Hits	229	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

VAV3_MOUSE
θ value	0.0330416 (rank : 112)	NC score	0.412433 (rank : 86)
Query Neighborhood Hits	229	Target Neighborhood Hits	404	Shared Neighborhood Hits	159
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHGG_MOUSE
θ value	0.0431538 (rank : 113)	NC score	0.233080 (rank : 145)
Query Neighborhood Hits	229	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BLK_MOUSE
θ value	0.0431538 (rank : 114)	NC score	0.134494 (rank : 216)
Query Neighborhood Hits	229	Target Neighborhood Hits	992	Shared Neighborhood Hits	117
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_MOUSE
θ value	0.0431538 (rank : 115)	NC score	0.154424 (rank : 200)
Query Neighborhood Hits	229	Target Neighborhood Hits	1017	Shared Neighborhood Hits	151
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ANM2_HUMAN
θ value	0.0563607 (rank : 116)	NC score	0.308852 (rank : 111)
Query Neighborhood Hits	229	Target Neighborhood Hits	175	Shared Neighborhood Hits	134
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_HUMAN
θ value	0.0563607 (rank : 117)	NC score	0.404032 (rank : 88)
Query Neighborhood Hits	229	Target Neighborhood Hits	242	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DNJC7_MOUSE
θ value	0.0563607 (rank : 118)	NC score	0.057899 (rank : 381)
Query Neighborhood Hits	229	Target Neighborhood Hits	211	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYI3, Q3TKR1, Q8BPG3, Q8CIL2, Q9CT29, Q9D026	Gene names	Dnajc7, Ttc2
Domain Architecture
Description	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) (MDj11).

NCF1_HUMAN
θ value	0.0563607 (rank : 119)	NC score	0.558068 (rank : 46)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_MOUSE
θ value	0.0563607 (rank : 120)	NC score	0.491465 (rank : 63)
Query Neighborhood Hits	229	Target Neighborhood Hits	267	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

VAV3_HUMAN
θ value	0.0563607 (rank : 121)	NC score	0.418428 (rank : 83)
Query Neighborhood Hits	229	Target Neighborhood Hits	398	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CSKP_MOUSE
θ value	0.0736092 (rank : 122)	NC score	0.069016 (rank : 352)
Query Neighborhood Hits	229	Target Neighborhood Hits	1027	Shared Neighborhood Hits	110
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

FNBP2_HUMAN
θ value	0.0736092 (rank : 123)	NC score	0.304766 (rank : 114)
Query Neighborhood Hits	229	Target Neighborhood Hits	432	Shared Neighborhood Hits	137
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP1_HUMAN
θ value	0.0736092 (rank : 124)	NC score	0.304562 (rank : 115)
Query Neighborhood Hits	229	Target Neighborhood Hits	390	Shared Neighborhood Hits	132
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ARHG9_HUMAN
θ value	0.0961366 (rank : 125)	NC score	0.391135 (rank : 92)
Query Neighborhood Hits	229	Target Neighborhood Hits	235	Shared Neighborhood Hits	146
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.0961366 (rank : 126)	NC score	0.390837 (rank : 93)
Query Neighborhood Hits	229	Target Neighborhood Hits	234	Shared Neighborhood Hits	144
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

BTK_HUMAN
θ value	0.0961366 (rank : 127)	NC score	0.159296 (rank : 192)
Query Neighborhood Hits	229	Target Neighborhood Hits	1026	Shared Neighborhood Hits	162
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FRK_HUMAN
θ value	0.0961366 (rank : 128)	NC score	0.145901 (rank : 206)
Query Neighborhood Hits	229	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ASPP1_MOUSE
θ value	0.125558 (rank : 129)	NC score	0.255157 (rank : 133)
Query Neighborhood Hits	229	Target Neighborhood Hits	1244	Shared Neighborhood Hits	155
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NEBL_HUMAN
θ value	0.125558 (rank : 130)	NC score	0.431297 (rank : 80)
Query Neighborhood Hits	229	Target Neighborhood Hits	457	Shared Neighborhood Hits	154
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NGEF_HUMAN
θ value	0.125558 (rank : 131)	NC score	0.256863 (rank : 131)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PLCG1_MOUSE
θ value	0.125558 (rank : 132)	NC score	0.385915 (rank : 96)
Query Neighborhood Hits	229	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

YES_MOUSE
θ value	0.125558 (rank : 133)	NC score	0.176387 (rank : 171)
Query Neighborhood Hits	229	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BCAR1_MOUSE
θ value	0.163984 (rank : 134)	NC score	0.407357 (rank : 87)
Query Neighborhood Hits	229	Target Neighborhood Hits	438	Shared Neighborhood Hits	145
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRSP3_HUMAN
θ value	0.163984 (rank : 135)	NC score	0.062823 (rank : 371)
Query Neighborhood Hits	229	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULK4, O95403, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667	Gene names	CRSP3, ARC130, DRIP130, KIAA1216, SUR2
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 3 (Cofactor required for Sp1 transcriptional activation subunit 3) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) (Activator-recruited cofactor 130 kDa component) (ARC130).

CSKP_HUMAN
θ value	0.163984 (rank : 136)	NC score	0.068940 (rank : 353)
Query Neighborhood Hits	229	Target Neighborhood Hits	1022	Shared Neighborhood Hits	103
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

IFT88_HUMAN
θ value	0.163984 (rank : 137)	NC score	0.073567 (rank : 342)
Query Neighborhood Hits	229	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q13099	Gene names	IFT88, TG737, TTC10
Domain Architecture
Description	Intraflagellar transport 88 homolog (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (Recessive polycystic kidney disease protein Tg737 homolog).

NGEF_MOUSE
θ value	0.163984 (rank : 138)	NC score	0.253968 (rank : 135)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

YES_HUMAN
θ value	0.163984 (rank : 139)	NC score	0.174452 (rank : 174)
Query Neighborhood Hits	229	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EFS_HUMAN
θ value	0.21417 (rank : 140)	NC score	0.398966 (rank : 89)
Query Neighborhood Hits	229	Target Neighborhood Hits	348	Shared Neighborhood Hits	133
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CDC27_HUMAN
θ value	0.279714 (rank : 141)	NC score	0.074613 (rank : 339)
Query Neighborhood Hits	229	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

FGR_HUMAN
θ value	0.279714 (rank : 142)	NC score	0.177070 (rank : 169)
Query Neighborhood Hits	229	Target Neighborhood Hits	1067	Shared Neighborhood Hits	166
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TXK_HUMAN
θ value	0.279714 (rank : 143)	NC score	0.120263 (rank : 243)
Query Neighborhood Hits	229	Target Neighborhood Hits	971	Shared Neighborhood Hits	114
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHG5_HUMAN
θ value	0.365318 (rank : 144)	NC score	0.269796 (rank : 123)
Query Neighborhood Hits	229	Target Neighborhood Hits	172	Shared Neighborhood Hits	94
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

BCAR1_HUMAN
θ value	0.365318 (rank : 145)	NC score	0.396532 (rank : 90)
Query Neighborhood Hits	229	Target Neighborhood Hits	554	Shared Neighborhood Hits	149
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ES8L3_MOUSE
θ value	0.365318 (rank : 146)	NC score	0.343592 (rank : 102)
Query Neighborhood Hits	229	Target Neighborhood Hits	168	Shared Neighborhood Hits	123
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GOGA3_MOUSE
θ value	0.365318 (rank : 147)	NC score	0.031565 (rank : 419)
Query Neighborhood Hits	229	Target Neighborhood Hits	1437	Shared Neighborhood Hits	34
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PLCG1_HUMAN
θ value	0.365318 (rank : 148)	NC score	0.367675 (rank : 99)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	145
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SYEP_HUMAN
θ value	0.365318 (rank : 149)	NC score	0.053010 (rank : 399)
Query Neighborhood Hits	229	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

BBS4_MOUSE
θ value	0.47712 (rank : 150)	NC score	0.067661 (rank : 355)
Query Neighborhood Hits	229	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C1Z7, Q3UYF0, Q8CA57	Gene names	Bbs4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein homolog.

RHG26_HUMAN
θ value	0.47712 (rank : 151)	NC score	0.267634 (rank : 125)
Query Neighborhood Hits	229	Target Neighborhood Hits	281	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB2_MOUSE
θ value	0.47712 (rank : 152)	NC score	0.311831 (rank : 110)
Query Neighborhood Hits	229	Target Neighborhood Hits	246	Shared Neighborhood Hits	97
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STS1_HUMAN
θ value	0.47712 (rank : 153)	NC score	0.207990 (rank : 152)
Query Neighborhood Hits	229	Target Neighborhood Hits	106	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHGG_HUMAN
θ value	0.62314 (rank : 154)	NC score	0.205784 (rank : 153)
Query Neighborhood Hits	229	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	0.62314 (rank : 155)	NC score	0.254935 (rank : 134)
Query Neighborhood Hits	229	Target Neighborhood Hits	956	Shared Neighborhood Hits	150
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EM55_MOUSE
θ value	0.62314 (rank : 156)	NC score	0.151404 (rank : 202)
Query Neighborhood Hits	229	Target Neighborhood Hits	221	Shared Neighborhood Hits	87
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

BIN1_HUMAN
θ value	0.813845 (rank : 157)	NC score	0.183464 (rank : 166)
Query Neighborhood Hits	229	Target Neighborhood Hits	335	Shared Neighborhood Hits	72
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	0.813845 (rank : 158)	NC score	0.184700 (rank : 165)
Query Neighborhood Hits	229	Target Neighborhood Hits	283	Shared Neighborhood Hits	76
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	0.813845 (rank : 159)	NC score	0.137229 (rank : 212)
Query Neighborhood Hits	229	Target Neighborhood Hits	994	Shared Neighborhood Hits	127
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BOC_HUMAN
θ value	0.813845 (rank : 160)	NC score	0.005695 (rank : 435)
Query Neighborhood Hits	229	Target Neighborhood Hits	543	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

FYN_HUMAN
θ value	0.813845 (rank : 161)	NC score	0.176480 (rank : 170)
Query Neighborhood Hits	229	Target Neighborhood Hits	1078	Shared Neighborhood Hits	173
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.813845 (rank : 162)	NC score	0.179399 (rank : 168)
Query Neighborhood Hits	229	Target Neighborhood Hits	1073	Shared Neighborhood Hits	173
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MYRIP_HUMAN
θ value	0.813845 (rank : 163)	NC score	0.026487 (rank : 424)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

PTN23_MOUSE
θ value	0.813845 (rank : 164)	NC score	0.012360 (rank : 429)
Query Neighborhood Hits	229	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RIMB2_HUMAN
θ value	0.813845 (rank : 165)	NC score	0.314680 (rank : 108)
Query Neighborhood Hits	229	Target Neighborhood Hits	263	Shared Neighborhood Hits	104
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

STS1_MOUSE
θ value	0.813845 (rank : 166)	NC score	0.204869 (rank : 154)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TCGAP_HUMAN
θ value	0.813845 (rank : 167)	NC score	0.212084 (rank : 151)
Query Neighborhood Hits	229	Target Neighborhood Hits	872	Shared Neighborhood Hits	124
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	0.813845 (rank : 168)	NC score	0.236214 (rank : 143)
Query Neighborhood Hits	229	Target Neighborhood Hits	409	Shared Neighborhood Hits	121
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANM2_MOUSE
θ value	1.06291 (rank : 169)	NC score	0.292763 (rank : 120)
Query Neighborhood Hits	229	Target Neighborhood Hits	175	Shared Neighborhood Hits	131
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_MOUSE
θ value	1.06291 (rank : 170)	NC score	0.333896 (rank : 104)
Query Neighborhood Hits	229	Target Neighborhood Hits	185	Shared Neighborhood Hits	115
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

EM55_HUMAN
θ value	1.06291 (rank : 171)	NC score	0.155326 (rank : 198)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

GOGA3_HUMAN
θ value	1.06291 (rank : 172)	NC score	0.028442 (rank : 423)
Query Neighborhood Hits	229	Target Neighborhood Hits	1317	Shared Neighborhood Hits	24
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

JIP1_HUMAN
θ value	1.06291 (rank : 173)	NC score	0.136618 (rank : 215)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	1.06291 (rank : 174)	NC score	0.136761 (rank : 214)
Query Neighborhood Hits	229	Target Neighborhood Hits	259	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

CD017_HUMAN
θ value	1.38821 (rank : 175)	NC score	0.042854 (rank : 416)
Query Neighborhood Hits	229	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q53FE4, Q6FI84, Q6IS77, Q9H0D9	Gene names	C4orf17
Domain Architecture	No domain graphic available
Description	Protein C4orf17.

F10A1_HUMAN
θ value	1.38821 (rank : 176)	NC score	0.049693 (rank : 411)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	15
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

FGR_MOUSE
θ value	1.38821 (rank : 177)	NC score	0.169492 (rank : 177)
Query Neighborhood Hits	229	Target Neighborhood Hits	1069	Shared Neighborhood Hits	167
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

IFT88_MOUSE
θ value	1.38821 (rank : 178)	NC score	0.062227 (rank : 372)
Query Neighborhood Hits	229	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	Q61371	Gene names	Ift88, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
Domain Architecture
Description	Intraflagellar transport 88 homolog (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (Recessive polycystic kidney disease protein Tg737) (TgN(Imorpk)737Rpw).

RNF17_MOUSE
θ value	1.38821 (rank : 179)	NC score	0.029209 (rank : 421)
Query Neighborhood Hits	229	Target Neighborhood Hits	147	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

TDRKH_MOUSE
θ value	1.38821 (rank : 180)	NC score	0.029439 (rank : 420)
Query Neighborhood Hits	229	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

ANR38_HUMAN
θ value	1.81305 (rank : 181)	NC score	0.023717 (rank : 425)
Query Neighborhood Hits	229	Target Neighborhood Hits	443	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

CSK_HUMAN
θ value	1.81305 (rank : 182)	NC score	0.124137 (rank : 233)
Query Neighborhood Hits	229	Target Neighborhood Hits	1009	Shared Neighborhood Hits	120
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	1.81305 (rank : 183)	NC score	0.124328 (rank : 231)
Query Neighborhood Hits	229	Target Neighborhood Hits	1009	Shared Neighborhood Hits	120
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	1.81305 (rank : 184)	NC score	0.417096 (rank : 85)
Query Neighborhood Hits	229	Target Neighborhood Hits	235	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DLG4_HUMAN
θ value	1.81305 (rank : 185)	NC score	0.079593 (rank : 323)
Query Neighborhood Hits	229	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

F10A1_MOUSE
θ value	1.81305 (rank : 186)	NC score	0.053111 (rank : 398)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q99L47, Q4FJT4	Gene names	St13, Fam10a1, Hip
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Protein ST13 homolog) (Protein FAM10A1).

SYEP_MOUSE
θ value	1.81305 (rank : 187)	NC score	0.049030 (rank : 412)
Query Neighborhood Hits	229	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

DBNL_HUMAN
θ value	2.36792 (rank : 188)	NC score	0.459624 (rank : 70)
Query Neighborhood Hits	229	Target Neighborhood Hits	244	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	2.36792 (rank : 189)	NC score	0.453049 (rank : 72)
Query Neighborhood Hits	229	Target Neighborhood Hits	306	Shared Neighborhood Hits	133
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DLG4_MOUSE
θ value	2.36792 (rank : 190)	NC score	0.075209 (rank : 336)
Query Neighborhood Hits	229	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

F10A4_HUMAN
θ value	2.36792 (rank : 191)	NC score	0.048931 (rank : 413)
Query Neighborhood Hits	229	Target Neighborhood Hits	249	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZP2	Gene names	FAM10A4
Domain Architecture	No domain graphic available
Description	Protein FAM10A4.

JIP2_HUMAN
θ value	2.36792 (rank : 192)	NC score	0.140690 (rank : 211)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	56
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	2.36792 (rank : 193)	NC score	0.144471 (rank : 209)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

NOXO1_MOUSE
θ value	2.36792 (rank : 194)	NC score	0.336024 (rank : 103)
Query Neighborhood Hits	229	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SSH2_MOUSE
θ value	2.36792 (rank : 195)	NC score	0.011193 (rank : 432)
Query Neighborhood Hits	229	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

BBS4_HUMAN
θ value	3.0926 (rank : 196)	NC score	0.059611 (rank : 378)
Query Neighborhood Hits	229	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RK4, Q8NHU9, Q96H45	Gene names	BBS4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein.

GPS2_HUMAN
θ value	3.0926 (rank : 197)	NC score	0.042154 (rank : 417)
Query Neighborhood Hits	229	Target Neighborhood Hits	459	Shared Neighborhood Hits	11
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

AMPH_MOUSE
θ value	4.03905 (rank : 198)	NC score	0.190872 (rank : 163)
Query Neighborhood Hits	229	Target Neighborhood Hits	291	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

DOCK1_HUMAN
θ value	4.03905 (rank : 199)	NC score	0.167361 (rank : 180)
Query Neighborhood Hits	229	Target Neighborhood Hits	191	Shared Neighborhood Hits	108
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

LCK_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.123113 (rank : 234)
Query Neighborhood Hits	229	Target Neighborhood Hits	987	Shared Neighborhood Hits	108
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	4.03905 (rank : 201)	NC score	0.121979 (rank : 237)
Query Neighborhood Hits	229	Target Neighborhood Hits	981	Shared Neighborhood Hits	107
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

RHG09_HUMAN
θ value	4.03905 (rank : 202)	NC score	0.087487 (rank : 302)
Query Neighborhood Hits	229	Target Neighborhood Hits	186	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

SRC_HUMAN
θ value	4.03905 (rank : 203)	NC score	0.168744 (rank : 178)
Query Neighborhood Hits	229	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TLE1_HUMAN
θ value	4.03905 (rank : 204)	NC score	0.006342 (rank : 434)
Query Neighborhood Hits	229	Target Neighborhood Hits	485	Shared Neighborhood Hits	10
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

AMPH_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.199056 (rank : 156)
Query Neighborhood Hits	229	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AN30A_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.021972 (rank : 427)
Query Neighborhood Hits	229	Target Neighborhood Hits	1119	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

DLG1_HUMAN
θ value	5.27518 (rank : 207)	NC score	0.076087 (rank : 333)
Query Neighborhood Hits	229	Target Neighborhood Hits	290	Shared Neighborhood Hits	62
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.073022 (rank : 346)
Query Neighborhood Hits	229	Target Neighborhood Hits	285	Shared Neighborhood Hits	58
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG3_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.077901 (rank : 329)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	67
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	5.27518 (rank : 210)	NC score	0.077459 (rank : 331)
Query Neighborhood Hits	229	Target Neighborhood Hits	274	Shared Neighborhood Hits	67
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

ES8L1_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.242098 (rank : 141)
Query Neighborhood Hits	229	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

F10A5_HUMAN
θ value	5.27518 (rank : 212)	NC score	0.048927 (rank : 414)
Query Neighborhood Hits	229	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

OM34_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.028763 (rank : 422)
Query Neighborhood Hits	229	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

P85A_HUMAN
θ value	5.27518 (rank : 214)	NC score	0.181895 (rank : 167)
Query Neighborhood Hits	229	Target Neighborhood Hits	479	Shared Neighborhood Hits	102
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.157258 (rank : 194)
Query Neighborhood Hits	229	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TXK_MOUSE
θ value	5.27518 (rank : 216)	NC score	0.128117 (rank : 223)
Query Neighborhood Hits	229	Target Neighborhood Hits	980	Shared Neighborhood Hits	129
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ABL2_HUMAN
θ value	6.88961 (rank : 217)	NC score	0.112474 (rank : 251)
Query Neighborhood Hits	229	Target Neighborhood Hits	1045	Shared Neighborhood Hits	107
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CLUA1_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.017234 (rank : 428)
Query Neighborhood Hits	229	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

DLG2_HUMAN
θ value	6.88961 (rank : 219)	NC score	0.081062 (rank : 317)
Query Neighborhood Hits	229	Target Neighborhood Hits	279	Shared Neighborhood Hits	70
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

NSG2_HUMAN
θ value	6.88961 (rank : 220)	NC score	0.012327 (rank : 430)
Query Neighborhood Hits	229	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y328, Q9UHX8	Gene names	NSG2
Domain Architecture
Description	Neuron-specific protein family member 2 (Protein p19) (HMP19).

P85B_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.151232 (rank : 203)
Query Neighborhood Hits	229	Target Neighborhood Hits	519	Shared Neighborhood Hits	78
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RFIP5_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.010999 (rank : 433)
Query Neighborhood Hits	229	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

TDRKH_HUMAN
θ value	6.88961 (rank : 223)	NC score	0.022272 (rank : 426)
Query Neighborhood Hits	229	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

K0372_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.038489 (rank : 418)
Query Neighborhood Hits	229	Target Neighborhood Hits	136	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

P85A_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.189944 (rank : 164)
Query Neighborhood Hits	229	Target Neighborhood Hits	435	Shared Neighborhood Hits	106
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SLY_HUMAN
θ value	8.99809 (rank : 226)	NC score	0.133720 (rank : 217)
Query Neighborhood Hits	229	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

STS2_HUMAN
θ value	8.99809 (rank : 227)	NC score	0.230375 (rank : 146)
Query Neighborhood Hits	229	Target Neighborhood Hits	108	Shared Neighborhood Hits	83
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TTC13_HUMAN
θ value	8.99809 (rank : 228)	NC score	0.048449 (rank : 415)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NBP0, Q8IVP8, Q8NBI0, Q8ND20	Gene names	TTC13
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 13 (TPR repeat protein 13).

UBP2L_MOUSE
θ value	8.99809 (rank : 229)	NC score	0.011375 (rank : 431)
Query Neighborhood Hits	229	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

3BP1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.060455 (rank : 375)
Query Neighborhood Hits	229	Target Neighborhood Hits	376	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABL1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.114814 (rank : 248)
Query Neighborhood Hits	229	Target Neighborhood Hits	1220	Shared Neighborhood Hits	117
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.114116 (rank : 249)
Query Neighborhood Hits	229	Target Neighborhood Hits	1178	Shared Neighborhood Hits	114
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABR_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.098201 (rank : 286)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.060703 (rank : 374)
Query Neighborhood Hits	229	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 235)	NC score	0.061971 (rank : 373)
Query Neighborhood Hits	229	Target Neighborhood Hits	1080	Shared Neighborhood Hits	75
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

APS_HUMAN
θ value	θ > 10 (rank : 236)	NC score	0.102749 (rank : 274)
Query Neighborhood Hits	229	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 237)	NC score	0.078935 (rank : 326)
Query Neighborhood Hits	229	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.124689 (rank : 228)
Query Neighborhood Hits	229	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.109238 (rank : 255)
Query Neighborhood Hits	229	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.108057 (rank : 259)
Query Neighborhood Hits	229	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.107300 (rank : 263)
Query Neighborhood Hits	229	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.165996 (rank : 183)
Query Neighborhood Hits	229	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.165560 (rank : 184)
Query Neighborhood Hits	229	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.154915 (rank : 199)
Query Neighborhood Hits	229	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.162664 (rank : 186)
Query Neighborhood Hits	229	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.127190 (rank : 225)
Query Neighborhood Hits	229	Target Neighborhood Hits	187	Shared Neighborhood Hits	23
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.131327 (rank : 221)
Query Neighborhood Hits	229	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.122340 (rank : 235)
Query Neighborhood Hits	229	Target Neighborhood Hits	375	Shared Neighborhood Hits	33
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.121335 (rank : 241)
Query Neighborhood Hits	229	Target Neighborhood Hits	351	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.121548 (rank : 239)
Query Neighborhood Hits	229	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.136931 (rank : 213)
Query Neighborhood Hits	229	Target Neighborhood Hits	214	Shared Neighborhood Hits	25
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPP2_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.201880 (rank : 155)
Query Neighborhood Hits	229	Target Neighborhood Hits	1156	Shared Neighborhood Hits	141
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.112599 (rank : 250)
Query Neighborhood Hits	229	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.115303 (rank : 247)
Query Neighborhood Hits	229	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.074861 (rank : 338)
Query Neighborhood Hits	229	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.073243 (rank : 344)
Query Neighborhood Hits	229	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.111011 (rank : 253)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.132464 (rank : 218)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.103229 (rank : 273)
Query Neighborhood Hits	229	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BLNK_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.052187 (rank : 406)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.056775 (rank : 385)
Query Neighborhood Hits	229	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.064483 (rank : 367)
Query Neighborhood Hits	229	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.064533 (rank : 366)
Query Neighborhood Hits	229	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CHIN_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.095356 (rank : 292)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.096998 (rank : 289)
Query Neighborhood Hits	229	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.095519 (rank : 291)
Query Neighborhood Hits	229	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.066993 (rank : 358)
Query Neighborhood Hits	229	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.160775 (rank : 189)
Query Neighborhood Hits	229	Target Neighborhood Hits	374	Shared Neighborhood Hits	69
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

DAPP1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.124287 (rank : 232)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.126558 (rank : 226)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDFL1_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.052746 (rank : 401)
Query Neighborhood Hits	229	Target Neighborhood Hits	353	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.051748 (rank : 408)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	10
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DLG2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.080704 (rank : 320)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DOCK2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.052895 (rank : 400)
Query Neighborhood Hits	229	Target Neighborhood Hits	90	Shared Neighborhood Hits	40
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.056898 (rank : 384)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DUET_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.059716 (rank : 377)
Query Neighborhood Hits	229	Target Neighborhood Hits	1220	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.127495 (rank : 224)
Query Neighborhood Hits	229	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.131544 (rank : 220)
Query Neighborhood Hits	229	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EP15_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.050121 (rank : 410)
Query Neighborhood Hits	229	Target Neighborhood Hits	820	Shared Neighborhood Hits	21
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.251915 (rank : 138)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.253152 (rank : 136)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	112
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.235560 (rank : 144)
Query Neighborhood Hits	229	Target Neighborhood Hits	162	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FARP1_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.074241 (rank : 341)
Query Neighborhood Hits	229	Target Neighborhood Hits	241	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.075235 (rank : 334)
Query Neighborhood Hits	229	Target Neighborhood Hits	240	Shared Neighborhood Hits	25
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.084144 (rank : 307)
Query Neighborhood Hits	229	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.071349 (rank : 348)
Query Neighborhood Hits	229	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.052621 (rank : 403)
Query Neighborhood Hits	229	Target Neighborhood Hits	978	Shared Neighborhood Hits	49
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.089654 (rank : 300)
Query Neighborhood Hits	229	Target Neighborhood Hits	367	Shared Neighborhood Hits	30
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.087352 (rank : 304)
Query Neighborhood Hits	229	Target Neighborhood Hits	387	Shared Neighborhood Hits	28
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.099693 (rank : 283)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.094229 (rank : 294)
Query Neighborhood Hits	229	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.100332 (rank : 282)
Query Neighborhood Hits	229	Target Neighborhood Hits	249	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.105675 (rank : 266)
Query Neighborhood Hits	229	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.103371 (rank : 272)
Query Neighborhood Hits	229	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.103668 (rank : 268)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.079086 (rank : 324)
Query Neighborhood Hits	229	Target Neighborhood Hits	237	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.083869 (rank : 308)
Query Neighborhood Hits	229	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FUT8_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.084682 (rank : 306)
Query Neighborhood Hits	229	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.080163 (rank : 321)
Query Neighborhood Hits	229	Target Neighborhood Hits	115	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GNRP_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.097607 (rank : 288)
Query Neighborhood Hits	229	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.107642 (rank : 262)
Query Neighborhood Hits	229	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.081668 (rank : 314)
Query Neighborhood Hits	229	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.083399 (rank : 309)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.105300 (rank : 267)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.108489 (rank : 257)
Query Neighborhood Hits	229	Target Neighborhood Hits	149	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.083248 (rank : 310)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.092523 (rank : 296)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.108480 (rank : 258)
Query Neighborhood Hits	229	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HGS_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.053519 (rank : 395)
Query Neighborhood Hits	229	Target Neighborhood Hits	517	Shared Neighborhood Hits	15
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.053474 (rank : 396)
Query Neighborhood Hits	229	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.103639 (rank : 269)
Query Neighborhood Hits	229	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.065641 (rank : 361)
Query Neighborhood Hits	229	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.262079 (rank : 128)
Query Neighborhood Hits	229	Target Neighborhood Hits	688	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.237698 (rank : 142)
Query Neighborhood Hits	229	Target Neighborhood Hits	1024	Shared Neighborhood Hits	147
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ILK1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.054491 (rank : 391)
Query Neighborhood Hits	229	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.054074 (rank : 393)
Query Neighborhood Hits	229	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.054720 (rank : 390)
Query Neighborhood Hits	229	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITK_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.111199 (rank : 252)
Query Neighborhood Hits	229	Target Neighborhood Hits	1016	Shared Neighborhood Hits	121
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.103475 (rank : 270)
Query Neighborhood Hits	229	Target Neighborhood Hits	985	Shared Neighborhood Hits	110
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.063709 (rank : 368)
Query Neighborhood Hits	229	Target Neighborhood Hits	901	Shared Neighborhood Hits	54
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.065341 (rank : 362)
Query Neighborhood Hits	229	Target Neighborhood Hits	944	Shared Neighborhood Hits	56
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.109323 (rank : 254)
Query Neighborhood Hits	229	Target Neighborhood Hits	90	Shared Neighborhood Hits	21
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.067490 (rank : 356)
Query Neighborhood Hits	229	Target Neighborhood Hits	531	Shared Neighborhood Hits	43
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.074879 (rank : 337)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.094538 (rank : 293)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.093662 (rank : 295)
Query Neighborhood Hits	229	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.081729 (rank : 313)
Query Neighborhood Hits	229	Target Neighborhood Hits	954	Shared Neighborhood Hits	75
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.082919 (rank : 312)
Query Neighborhood Hits	229	Target Neighborhood Hits	952	Shared Neighborhood Hits	77
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.157220 (rank : 195)
Query Neighborhood Hits	229	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.129420 (rank : 222)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MPP2_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.090898 (rank : 297)
Query Neighborhood Hits	229	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.090351 (rank : 299)
Query Neighborhood Hits	229	Target Neighborhood Hits	189	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.063374 (rank : 369)
Query Neighborhood Hits	229	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.063192 (rank : 370)
Query Neighborhood Hits	229	Target Neighborhood Hits	165	Shared Neighborhood Hits	33
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.081628 (rank : 315)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.087443 (rank : 303)
Query Neighborhood Hits	229	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.107657 (rank : 261)
Query Neighborhood Hits	229	Target Neighborhood Hits	231	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.106526 (rank : 265)
Query Neighborhood Hits	229	Target Neighborhood Hits	226	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.125504 (rank : 227)
Query Neighborhood Hits	229	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.121713 (rank : 238)
Query Neighborhood Hits	229	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.251921 (rank : 137)
Query Neighborhood Hits	229	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

OPHN1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.057076 (rank : 383)
Query Neighborhood Hits	229	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.054467 (rank : 392)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.124631 (rank : 229)
Query Neighborhood Hits	229	Target Neighborhood Hits	451	Shared Neighborhood Hits	58
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.124543 (rank : 230)
Query Neighborhood Hits	229	Target Neighborhood Hits	401	Shared Neighborhood Hits	57
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PACN3_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.444275 (rank : 79)
Query Neighborhood Hits	229	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.446885 (rank : 75)
Query Neighborhood Hits	229	Target Neighborhood Hits	380	Shared Neighborhood Hits	161
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.303062 (rank : 116)
Query Neighborhood Hits	229	Target Neighborhood Hits	128	Shared Neighborhood Hits	99
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.307844 (rank : 112)
Query Neighborhood Hits	229	Target Neighborhood Hits	126	Shared Neighborhood Hits	103
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.166198 (rank : 182)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.074360 (rank : 340)
Query Neighborhood Hits	229	Target Neighborhood Hits	200	Shared Neighborhood Hits	19
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.100591 (rank : 281)
Query Neighborhood Hits	229	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.090399 (rank : 298)
Query Neighborhood Hits	229	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.161103 (rank : 188)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK6_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.116966 (rank : 246)
Query Neighborhood Hits	229	Target Neighborhood Hits	1020	Shared Neighborhood Hits	146
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.119330 (rank : 244)
Query Neighborhood Hits	229	Target Neighborhood Hits	1026	Shared Neighborhood Hits	143
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.080760 (rank : 319)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.080772 (rank : 318)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.069889 (rank : 351)
Query Neighborhood Hits	229	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.070987 (rank : 349)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.149950 (rank : 204)
Query Neighborhood Hits	229	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.053885 (rank : 394)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	7
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.052098 (rank : 407)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.065809 (rank : 359)
Query Neighborhood Hits	229	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.065096 (rank : 364)
Query Neighborhood Hits	229	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.108794 (rank : 256)
Query Neighborhood Hits	229	Target Neighborhood Hits	641	Shared Neighborhood Hits	37
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG12_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.073218 (rank : 345)
Query Neighborhood Hits	229	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.078341 (rank : 328)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIMB1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.167356 (rank : 181)
Query Neighborhood Hits	229	Target Neighborhood Hits	1479	Shared Neighborhood Hits	128
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.168576 (rank : 179)
Query Neighborhood Hits	229	Target Neighborhood Hits	1376	Shared Neighborhood Hits	143
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SAMN1_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.083167 (rank : 311)
Query Neighborhood Hits	229	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.077463 (rank : 330)
Query Neighborhood Hits	229	Target Neighborhood Hits	69	Shared Neighborhood Hits	37
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.088344 (rank : 301)
Query Neighborhood Hits	229	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.081561 (rank : 316)
Query Neighborhood Hits	229	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.078972 (rank : 325)
Query Neighborhood Hits	229	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.080059 (rank : 322)
Query Neighborhood Hits	229	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.120866 (rank : 242)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.122065 (rank : 236)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.067488 (rank : 357)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.078873 (rank : 327)
Query Neighborhood Hits	229	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.067852 (rank : 354)
Query Neighborhood Hits	229	Target Neighborhood Hits	149	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.072724 (rank : 347)
Query Neighborhood Hits	229	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.051578 (rank : 409)
Query Neighborhood Hits	229	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.070948 (rank : 350)
Query Neighborhood Hits	229	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.077054 (rank : 332)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN2_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.198595 (rank : 157)
Query Neighborhood Hits	229	Target Neighborhood Hits	446	Shared Neighborhood Hits	108
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.100675 (rank : 280)
Query Neighborhood Hits	229	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.103446 (rank : 271)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.101543 (rank : 278)
Query Neighborhood Hits	229	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.102335 (rank : 276)
Query Neighborhood Hits	229	Target Neighborhood Hits	180	Shared Neighborhood Hits	54
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.098536 (rank : 285)
Query Neighborhood Hits	229	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.097915 (rank : 287)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.101231 (rank : 279)
Query Neighborhood Hits	229	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.106833 (rank : 264)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.099478 (rank : 284)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.102277 (rank : 277)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.102449 (rank : 275)
Query Neighborhood Hits	229	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.108026 (rank : 260)
Query Neighborhood Hits	229	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.245038 (rank : 140)
Query Neighborhood Hits	229	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.246747 (rank : 139)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.219605 (rank : 149)
Query Neighborhood Hits	229	Target Neighborhood Hits	86	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.221188 (rank : 147)
Query Neighborhood Hits	229	Target Neighborhood Hits	88	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.175133 (rank : 173)
Query Neighborhood Hits	229	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.173307 (rank : 175)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.198475 (rank : 158)
Query Neighborhood Hits	229	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.194240 (rank : 160)
Query Neighborhood Hits	229	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.152450 (rank : 201)
Query Neighborhood Hits	229	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.305768 (rank : 113)
Query Neighborhood Hits	229	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.314069 (rank : 109)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.191003 (rank : 162)
Query Neighborhood Hits	229	Target Neighborhood Hits	148	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.163756 (rank : 185)
Query Neighborhood Hits	229	Target Neighborhood Hits	141	Shared Neighborhood Hits	77
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOCS2_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.052707 (rank : 402)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	33
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.055314 (rank : 389)
Query Neighborhood Hits	229	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.055838 (rank : 387)
Query Neighborhood Hits	229	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.055728 (rank : 388)
Query Neighborhood Hits	229	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.075220 (rank : 335)
Query Neighborhood Hits	229	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOS1_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.053391 (rank : 397)
Query Neighborhood Hits	229	Target Neighborhood Hits	274	Shared Neighborhood Hits	19
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.220367 (rank : 148)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.192346 (rank : 161)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.144886 (rank : 208)
Query Neighborhood Hits	229	Target Neighborhood Hits	1033	Shared Neighborhood Hits	144
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.086351 (rank : 305)
Query Neighborhood Hits	229	Target Neighborhood Hits	946	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.095597 (rank : 290)
Query Neighborhood Hits	229	Target Neighborhood Hits	964	Shared Neighborhood Hits	95
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TEC_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.121459 (rank : 240)
Query Neighborhood Hits	229	Target Neighborhood Hits	1006	Shared Neighborhood Hits	127
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.118196 (rank : 245)
Query Neighborhood Hits	229	Target Neighborhood Hits	1006	Shared Neighborhood Hits	125
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENS4_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.052225 (rank : 405)
Query Neighborhood Hits	229	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.052289 (rank : 404)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.055955 (rank : 386)
Query Neighborhood Hits	229	Target Neighborhood Hits	1103	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.057330 (rank : 382)
Query Neighborhood Hits	229	Target Neighborhood Hits	1333	Shared Neighborhood Hits	43
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.155435 (rank : 197)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.158074 (rank : 193)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TOM1_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.059428 (rank : 379)
Query Neighborhood Hits	229	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

TOM1_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.059043 (rank : 380)
Query Neighborhood Hits	229	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

TRIO_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.073533 (rank : 343)
Query Neighborhood Hits	229	Target Neighborhood Hits	1580	Shared Neighborhood Hits	86
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZAP70_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.065193 (rank : 363)
Query Neighborhood Hits	229	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.065646 (rank : 360)
Query Neighborhood Hits	229	Target Neighborhood Hits	905	Shared Neighborhood Hits	54
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

NCF2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	229	Target Neighborhood Hits	229	Shared Neighborhood Hits	229
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CD2AP_HUMAN
NC score	0.735409 (rank : 2)	θ value	1.9326e-10 (rank : 2)
Query Neighborhood Hits	229	Target Neighborhood Hits	315	Shared Neighborhood Hits	182
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.731709 (rank : 3)	θ value	2.79066e-09 (rank : 4)
Query Neighborhood Hits	229	Target Neighborhood Hits	336	Shared Neighborhood Hits	177
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

VINEX_MOUSE
NC score	0.709833 (rank : 4)	θ value	4.76016e-09 (rank : 6)
Query Neighborhood Hits	229	Target Neighborhood Hits	286	Shared Neighborhood Hits	182
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SH3K1_MOUSE
NC score	0.707221 (rank : 5)	θ value	1.53129e-07 (rank : 14)
Query Neighborhood Hits	229	Target Neighborhood Hits	332	Shared Neighborhood Hits	173
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

VINEX_HUMAN
NC score	0.706599 (rank : 6)	θ value	3.08544e-08 (rank : 8)
Query Neighborhood Hits	229	Target Neighborhood Hits	270	Shared Neighborhood Hits	178
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3K1_HUMAN
NC score	0.703743 (rank : 7)	θ value	6.43352e-06 (rank : 20)
Query Neighborhood Hits	229	Target Neighborhood Hits	341	Shared Neighborhood Hits	172
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SRBS1_MOUSE
NC score	0.674696 (rank : 8)	θ value	6.43352e-06 (rank : 21)
Query Neighborhood Hits	229	Target Neighborhood Hits	409	Shared Neighborhood Hits	180
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.668850 (rank : 9)	θ value	1.29631e-06 (rank : 17)
Query Neighborhood Hits	229	Target Neighborhood Hits	396	Shared Neighborhood Hits	179
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_MOUSE
NC score	0.661931 (rank : 10)	θ value	6.87365e-08 (rank : 11)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	136
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_HUMAN
NC score	0.649167 (rank : 11)	θ value	1.17247e-07 (rank : 13)
Query Neighborhood Hits	229	Target Neighborhood Hits	161	Shared Neighborhood Hits	122
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_MOUSE
NC score	0.630742 (rank : 12)	θ value	5.44631e-05 (rank : 33)
Query Neighborhood Hits	229	Target Neighborhood Hits	266	Shared Neighborhood Hits	172
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

STAC_HUMAN
NC score	0.624648 (rank : 13)	θ value	1.87187e-05 (rank : 25)
Query Neighborhood Hits	229	Target Neighborhood Hits	276	Shared Neighborhood Hits	163
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HCLS1_MOUSE
NC score	0.623903 (rank : 14)	θ value	5.44631e-05 (rank : 34)
Query Neighborhood Hits	229	Target Neighborhood Hits	329	Shared Neighborhood Hits	154
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI2_HUMAN
NC score	0.623787 (rank : 15)	θ value	5.44631e-05 (rank : 32)
Query Neighborhood Hits	229	Target Neighborhood Hits	350	Shared Neighborhood Hits	172
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SRC8_HUMAN
NC score	0.623060 (rank : 16)	θ value	5.44631e-05 (rank : 35)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	161
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_HUMAN
NC score	0.618350 (rank : 17)	θ value	0.000786445 (rank : 59)
Query Neighborhood Hits	229	Target Neighborhood Hits	358	Shared Neighborhood Hits	153
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_MOUSE
NC score	0.618135 (rank : 18)	θ value	7.1131e-05 (rank : 37)
Query Neighborhood Hits	229	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SRC8_MOUSE
NC score	0.616737 (rank : 19)	θ value	7.1131e-05 (rank : 38)
Query Neighborhood Hits	229	Target Neighborhood Hits	292	Shared Neighborhood Hits	160
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC_MOUSE
NC score	0.607995 (rank : 20)	θ value	4.1701e-05 (rank : 31)
Query Neighborhood Hits	229	Target Neighborhood Hits	268	Shared Neighborhood Hits	162
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G3_MOUSE
NC score	0.607648 (rank : 21)	θ value	9.29e-05 (rank : 39)
Query Neighborhood Hits	229	Target Neighborhood Hits	236	Shared Neighborhood Hits	167
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

STAM1_MOUSE
NC score	0.606046 (rank : 22)	θ value	8.40245e-06 (rank : 22)
Query Neighborhood Hits	229	Target Neighborhood Hits	273	Shared Neighborhood Hits	167
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

DNMBP_HUMAN
NC score	0.605944 (rank : 23)	θ value	5.62301e-10 (rank : 3)
Query Neighborhood Hits	229	Target Neighborhood Hits	413	Shared Neighborhood Hits	181
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM1_HUMAN
NC score	0.604974 (rank : 24)	θ value	1.09739e-05 (rank : 24)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	169
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.599787 (rank : 25)	θ value	2.44474e-05 (rank : 27)
Query Neighborhood Hits	229	Target Neighborhood Hits	285	Shared Neighborhood Hits	167
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI1_HUMAN
NC score	0.596934 (rank : 26)	θ value	0.000121331 (rank : 40)
Query Neighborhood Hits	229	Target Neighborhood Hits	257	Shared Neighborhood Hits	165
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_HUMAN
NC score	0.595711 (rank : 27)	θ value	0.00020696 (rank : 50)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

GRB2_HUMAN
NC score	0.595698 (rank : 28)	θ value	0.000158464 (rank : 45)
Query Neighborhood Hits	229	Target Neighborhood Hits	310	Shared Neighborhood Hits	179
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH3G3_HUMAN
NC score	0.595677 (rank : 29)	θ value	0.000158464 (rank : 46)
Query Neighborhood Hits	229	Target Neighborhood Hits	222	Shared Neighborhood Hits	159
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

GRB2_MOUSE
NC score	0.595263 (rank : 30)	θ value	0.000121331 (rank : 41)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	179
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SH3G2_MOUSE
NC score	0.593526 (rank : 31)	θ value	0.000270298 (rank : 52)
Query Neighborhood Hits	229	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

DNMBP_MOUSE
NC score	0.588885 (rank : 32)	θ value	6.87365e-08 (rank : 9)
Query Neighborhood Hits	229	Target Neighborhood Hits	435	Shared Neighborhood Hits	179
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM2_HUMAN
NC score	0.586516 (rank : 33)	θ value	5.44631e-05 (rank : 36)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	166
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH3G1_MOUSE
NC score	0.585444 (rank : 34)	θ value	3.19293e-05 (rank : 28)
Query Neighborhood Hits	229	Target Neighborhood Hits	291	Shared Neighborhood Hits	161
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

STAC3_HUMAN
NC score	0.584149 (rank : 35)	θ value	8.97725e-08 (rank : 12)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	141
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.583309 (rank : 36)	θ value	3.41135e-07 (rank : 15)
Query Neighborhood Hits	229	Target Neighborhood Hits	232	Shared Neighborhood Hits	141
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SH3G1_HUMAN
NC score	0.582431 (rank : 37)	θ value	4.1701e-05 (rank : 30)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	163
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GRAP2_MOUSE
NC score	0.581729 (rank : 38)	θ value	0.000461057 (rank : 56)
Query Neighborhood Hits	229	Target Neighborhood Hits	297	Shared Neighborhood Hits	179
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_HUMAN
NC score	0.576535 (rank : 39)	θ value	1.09739e-05 (rank : 23)
Query Neighborhood Hits	229	Target Neighborhood Hits	389	Shared Neighborhood Hits	177
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP2_HUMAN
NC score	0.575484 (rank : 40)	θ value	0.00035302 (rank : 53)
Query Neighborhood Hits	229	Target Neighborhood Hits	304	Shared Neighborhood Hits	178
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCK1_HUMAN
NC score	0.572134 (rank : 41)	θ value	0.00298849 (rank : 74)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	178
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PPIP1_MOUSE
NC score	0.570485 (rank : 42)	θ value	6.43352e-06 (rank : 19)
Query Neighborhood Hits	229	Target Neighborhood Hits	377	Shared Neighborhood Hits	176
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

GRAP_HUMAN
NC score	0.567283 (rank : 43)	θ value	2.44474e-05 (rank : 26)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	179
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.566839 (rank : 44)	θ value	0.00020696 (rank : 49)
Query Neighborhood Hits	229	Target Neighborhood Hits	310	Shared Neighborhood Hits	167
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP_MOUSE
NC score	0.561758 (rank : 45)	θ value	0.00102713 (rank : 62)
Query Neighborhood Hits	229	Target Neighborhood Hits	309	Shared Neighborhood Hits	180
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF1_HUMAN
NC score	0.558068 (rank : 46)	θ value	0.0563607 (rank : 119)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
NC score	0.557026 (rank : 47)	θ value	0.0193708 (rank : 108)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	149
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CRKL_HUMAN
NC score	0.549321 (rank : 48)	θ value	0.000270298 (rank : 51)
Query Neighborhood Hits	229	Target Neighborhood Hits	313	Shared Neighborhood Hits	170
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ARHG7_MOUSE
NC score	0.543779 (rank : 49)	θ value	0.00665767 (rank : 90)
Query Neighborhood Hits	229	Target Neighborhood Hits	396	Shared Neighborhood Hits	183
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CRK_MOUSE
NC score	0.541778 (rank : 50)	θ value	0.000461057 (rank : 55)
Query Neighborhood Hits	229	Target Neighborhood Hits	314	Shared Neighborhood Hits	170
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_MOUSE
NC score	0.539777 (rank : 51)	θ value	0.000602161 (rank : 57)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	166
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
NC score	0.538478 (rank : 52)	θ value	0.000461057 (rank : 54)
Query Neighborhood Hits	229	Target Neighborhood Hits	308	Shared Neighborhood Hits	171
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI3_MOUSE
NC score	0.538410 (rank : 53)	θ value	0.0193708 (rank : 102)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG7_HUMAN
NC score	0.534481 (rank : 54)	θ value	0.00298849 (rank : 72)
Query Neighborhood Hits	229	Target Neighborhood Hits	347	Shared Neighborhood Hits	177
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ABI3_HUMAN
NC score	0.534306 (rank : 55)	θ value	0.0252991 (rank : 109)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	131
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG6_MOUSE
NC score	0.524227 (rank : 56)	θ value	0.00390308 (rank : 77)
Query Neighborhood Hits	229	Target Neighborhood Hits	394	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG6_HUMAN
NC score	0.514316 (rank : 57)	θ value	0.0148317 (rank : 97)
Query Neighborhood Hits	229	Target Neighborhood Hits	376	Shared Neighborhood Hits	166
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PACN2_MOUSE
NC score	0.505650 (rank : 58)	θ value	0.00228821 (rank : 69)
Query Neighborhood Hits	229	Target Neighborhood Hits	382	Shared Neighborhood Hits	173
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.502364 (rank : 59)	θ value	0.00390308 (rank : 79)
Query Neighborhood Hits	229	Target Neighborhood Hits	339	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.498442 (rank : 60)	θ value	0.00509761 (rank : 89)
Query Neighborhood Hits	229	Target Neighborhood Hits	283	Shared Neighborhood Hits	167
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.497542 (rank : 61)	θ value	0.00509761 (rank : 88)
Query Neighborhood Hits	229	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

OSTF1_HUMAN
NC score	0.494488 (rank : 62)	θ value	4.1701e-05 (rank : 29)
Query Neighborhood Hits	229	Target Neighborhood Hits	466	Shared Neighborhood Hits	175
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NPHP1_MOUSE
NC score	0.491465 (rank : 63)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	229	Target Neighborhood Hits	267	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_MOUSE
NC score	0.485877 (rank : 64)	θ value	2.88788e-06 (rank : 18)
Query Neighborhood Hits	229	Target Neighborhood Hits	467	Shared Neighborhood Hits	174
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

LASP1_HUMAN
NC score	0.483487 (rank : 65)	θ value	0.00509761 (rank : 84)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	151
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.480040 (rank : 66)	θ value	0.00509761 (rank : 85)
Query Neighborhood Hits	229	Target Neighborhood Hits	297	Shared Neighborhood Hits	150
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ITSN2_HUMAN
NC score	0.476249 (rank : 67)	θ value	6.87365e-08 (rank : 10)
Query Neighborhood Hits	229	Target Neighborhood Hits	1173	Shared Neighborhood Hits	190
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV_MOUSE
NC score	0.470718 (rank : 68)	θ value	0.00390308 (rank : 83)
Query Neighborhood Hits	229	Target Neighborhood Hits	430	Shared Neighborhood Hits	171
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.469355 (rank : 69)	θ value	0.00390308 (rank : 82)
Query Neighborhood Hits	229	Target Neighborhood Hits	452	Shared Neighborhood Hits	167
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DBNL_HUMAN
NC score	0.459624 (rank : 70)	θ value	2.36792 (rank : 188)
Query Neighborhood Hits	229	Target Neighborhood Hits	244	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ITSN2_MOUSE
NC score	0.453293 (rank : 71)	θ value	9.92553e-07 (rank : 16)
Query Neighborhood Hits	229	Target Neighborhood Hits	1371	Shared Neighborhood Hits	188
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

DBNL_MOUSE
NC score	0.453049 (rank : 72)	θ value	2.36792 (rank : 189)
Query Neighborhood Hits	229	Target Neighborhood Hits	306	Shared Neighborhood Hits	133
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NPHP1_HUMAN
NC score	0.448677 (rank : 73)	θ value	0.00134147 (rank : 65)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	140
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ITSN1_MOUSE
NC score	0.448386 (rank : 74)	θ value	2.79066e-09 (rank : 5)
Query Neighborhood Hits	229	Target Neighborhood Hits	1669	Shared Neighborhood Hits	194
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PACN3_MOUSE
NC score	0.446885 (rank : 75)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	229	Target Neighborhood Hits	380	Shared Neighborhood Hits	161
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ITSN1_HUMAN
NC score	0.446640 (rank : 76)	θ value	6.21693e-09 (rank : 7)
Query Neighborhood Hits	229	Target Neighborhood Hits	1757	Shared Neighborhood Hits	195
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VAV2_MOUSE
NC score	0.446562 (rank : 77)	θ value	0.00175202 (rank : 67)
Query Neighborhood Hits	229	Target Neighborhood Hits	456	Shared Neighborhood Hits	161
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.446434 (rank : 78)	θ value	0.00175202 (rank : 66)
Query Neighborhood Hits	229	Target Neighborhood Hits	453	Shared Neighborhood Hits	161
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PACN3_HUMAN
NC score	0.444275 (rank : 79)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	229	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NEBL_HUMAN
NC score	0.431297 (rank : 80)	θ value	0.125558 (rank : 130)
Query Neighborhood Hits	229	Target Neighborhood Hits	457	Shared Neighborhood Hits	154
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

AHI1_MOUSE
NC score	0.426957 (rank : 81)	θ value	0.00390308 (rank : 76)
Query Neighborhood Hits	229	Target Neighborhood Hits	496	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AHI1_HUMAN
NC score	0.425958 (rank : 82)	θ value	0.00298849 (rank : 71)
Query Neighborhood Hits	229	Target Neighborhood Hits	537	Shared Neighborhood Hits	174
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

VAV3_HUMAN
NC score	0.418428 (rank : 83)	θ value	0.0563607 (rank : 121)
Query Neighborhood Hits	229	Target Neighborhood Hits	398	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

EFS_MOUSE
NC score	0.417971 (rank : 84)	θ value	0.00390308 (rank : 78)
Query Neighborhood Hits	229	Target Neighborhood Hits	389	Shared Neighborhood Hits	137
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CT032_HUMAN
NC score	0.417096 (rank : 85)	θ value	1.81305 (rank : 184)
Query Neighborhood Hits	229	Target Neighborhood Hits	235	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VAV3_MOUSE
NC score	0.412433 (rank : 86)	θ value	0.0330416 (rank : 112)
Query Neighborhood Hits	229	Target Neighborhood Hits	404	Shared Neighborhood Hits	159
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BCAR1_MOUSE
NC score	0.407357 (rank : 87)	θ value	0.163984 (rank : 134)
Query Neighborhood Hits	229	Target Neighborhood Hits	438	Shared Neighborhood Hits	145
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ARHG4_HUMAN
NC score	0.404032 (rank : 88)	θ value	0.0563607 (rank : 117)
Query Neighborhood Hits	229	Target Neighborhood Hits	242	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

EFS_HUMAN
NC score	0.398966 (rank : 89)	θ value	0.21417 (rank : 140)
Query Neighborhood Hits	229	Target Neighborhood Hits	348	Shared Neighborhood Hits	133
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

BCAR1_HUMAN
NC score	0.396532 (rank : 90)	θ value	0.365318 (rank : 145)
Query Neighborhood Hits	229	Target Neighborhood Hits	554	Shared Neighborhood Hits	149
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NEBU_HUMAN
NC score	0.394363 (rank : 91)	θ value	0.00298849 (rank : 75)
Query Neighborhood Hits	229	Target Neighborhood Hits	420	Shared Neighborhood Hits	153
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ARHG9_HUMAN
NC score	0.391135 (rank : 92)	θ value	0.0961366 (rank : 125)
Query Neighborhood Hits	229	Target Neighborhood Hits	235	Shared Neighborhood Hits	146
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.390837 (rank : 93)	θ value	0.0961366 (rank : 126)
Query Neighborhood Hits	229	Target Neighborhood Hits	234	Shared Neighborhood Hits	144
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

RUSC1_HUMAN
NC score	0.386802 (rank : 94)	θ value	0.00869519 (rank : 94)
Query Neighborhood Hits	229	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CASL_MOUSE
NC score	0.386629 (rank : 95)	θ value	0.00869519 (rank : 92)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	130
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PLCG1_MOUSE
NC score	0.385915 (rank : 96)	θ value	0.125558 (rank : 132)
Query Neighborhood Hits	229	Target Neighborhood Hits	314	Shared Neighborhood Hits	151
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CASL_HUMAN
NC score	0.383193 (rank : 97)	θ value	0.0193708 (rank : 103)
Query Neighborhood Hits	229	Target Neighborhood Hits	259	Shared Neighborhood Hits	127
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PLCG2_HUMAN
NC score	0.381292 (rank : 98)	θ value	0.00228821 (rank : 70)
Query Neighborhood Hits	229	Target Neighborhood Hits	280	Shared Neighborhood Hits	144
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.367675 (rank : 99)	θ value	0.365318 (rank : 148)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	145
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RUSC1_MOUSE
NC score	0.364182 (rank : 100)	θ value	0.0252991 (rank : 110)
Query Neighborhood Hits	229	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RHG04_HUMAN
NC score	0.361845 (rank : 101)	θ value	0.00390308 (rank : 80)
Query Neighborhood Hits	229	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ES8L3_MOUSE
NC score	0.343592 (rank : 102)	θ value	0.365318 (rank : 146)
Query Neighborhood Hits	229	Target Neighborhood Hits	168	Shared Neighborhood Hits	123
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NOXO1_MOUSE
NC score	0.336024 (rank : 103)	θ value	2.36792 (rank : 194)
Query Neighborhood Hits	229	Target Neighborhood Hits	114	Shared Neighborhood Hits	102
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ARHG4_MOUSE
NC score	0.333896 (rank : 104)	θ value	1.06291 (rank : 170)
Query Neighborhood Hits	229	Target Neighborhood Hits	185	Shared Neighborhood Hits	115
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SRGP2_MOUSE
NC score	0.329654 (rank : 105)	θ value	0.00102713 (rank : 64)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	137
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ES8L3_HUMAN
NC score	0.329080 (rank : 106)	θ value	0.0148317 (rank : 98)
Query Neighborhood Hits	229	Target Neighborhood Hits	206	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SRGP2_HUMAN
NC score	0.325898 (rank : 107)	θ value	0.00102713 (rank : 63)
Query Neighborhood Hits	229	Target Neighborhood Hits	331	Shared Neighborhood Hits	136
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RIMB2_HUMAN
NC score	0.314680 (rank : 108)	θ value	0.813845 (rank : 165)
Query Neighborhood Hits	229	Target Neighborhood Hits	263	Shared Neighborhood Hits	104
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SNX18_MOUSE
NC score	0.314069 (rank : 109)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	229	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RIMB2_MOUSE
NC score	0.311831 (rank : 110)	θ value	0.47712 (rank : 152)
Query Neighborhood Hits	229	Target Neighborhood Hits	246	Shared Neighborhood Hits	97
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ANM2_HUMAN
NC score	0.308852 (rank : 111)	θ value	0.0563607 (rank : 116)
Query Neighborhood Hits	229	Target Neighborhood Hits	175	Shared Neighborhood Hits	134
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PEX13_MOUSE
NC score	0.307844 (rank : 112)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	229	Target Neighborhood Hits	126	Shared Neighborhood Hits	103
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SNX18_HUMAN
NC score	0.305768 (rank : 113)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	229	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

FNBP2_HUMAN
NC score	0.304766 (rank : 114)	θ value	0.0736092 (rank : 123)
Query Neighborhood Hits	229	Target Neighborhood Hits	432	Shared Neighborhood Hits	137
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP1_HUMAN
NC score	0.304562 (rank : 115)	θ value	0.0736092 (rank : 124)
Query Neighborhood Hits	229	Target Neighborhood Hits	390	Shared Neighborhood Hits	132
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

PEX13_HUMAN
NC score	0.303062 (rank : 116)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	229	Target Neighborhood Hits	128	Shared Neighborhood Hits	99
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ES8L2_HUMAN
NC score	0.298028 (rank : 117)	θ value	0.000158464 (rank : 43)
Query Neighborhood Hits	229	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
NC score	0.297724 (rank : 118)	θ value	0.000158464 (rank : 44)
Query Neighborhood Hits	229	Target Neighborhood Hits	169	Shared Neighborhood Hits	106
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

DDEF1_MOUSE
NC score	0.294602 (rank : 119)	θ value	0.0193708 (rank : 104)
Query Neighborhood Hits	229	Target Neighborhood Hits	592	Shared Neighborhood Hits	133
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ANM2_MOUSE
NC score	0.292763 (rank : 120)	θ value	1.06291 (rank : 169)
Query Neighborhood Hits	229	Target Neighborhood Hits	175	Shared Neighborhood Hits	131
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

DDEF2_MOUSE
NC score	0.280089 (rank : 121)	θ value	0.00102713 (rank : 61)
Query Neighborhood Hits	229	Target Neighborhood Hits	625	Shared Neighborhood Hits	138
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.276687 (rank : 122)	θ value	0.00102713 (rank : 60)
Query Neighborhood Hits	229	Target Neighborhood Hits	599	Shared Neighborhood Hits	141
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ARHG5_HUMAN
NC score	0.269796 (rank : 123)	θ value	0.365318 (rank : 144)
Query Neighborhood Hits	229	Target Neighborhood Hits	172	Shared Neighborhood Hits	94
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SPTA2_HUMAN
NC score	0.269632 (rank : 124)	θ value	0.00869519 (rank : 95)
Query Neighborhood Hits	229	Target Neighborhood Hits	888	Shared Neighborhood Hits	161
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

RHG26_HUMAN
NC score	0.267634 (rank : 125)	θ value	0.47712 (rank : 151)
Query Neighborhood Hits	229	Target Neighborhood Hits	281	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

MYO1F_MOUSE
NC score	0.263787 (rank : 126)	θ value	0.00509761 (rank : 87)
Query Neighborhood Hits	229	Target Neighborhood Hits	262	Shared Neighborhood Hits	166
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.263433 (rank : 127)	θ value	0.00509761 (rank : 86)
Query Neighborhood Hits	229	Target Neighborhood Hits	275	Shared Neighborhood Hits	166
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

IASPP_HUMAN
NC score	0.262079 (rank : 128)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	229	Target Neighborhood Hits	688	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SPTA1_HUMAN
NC score	0.257292 (rank : 129)	θ value	0.000158464 (rank : 47)
Query Neighborhood Hits	229	Target Neighborhood Hits	748	Shared Neighborhood Hits	151
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

MYO1E_HUMAN
NC score	0.257181 (rank : 130)	θ value	0.000602161 (rank : 58)
Query Neighborhood Hits	229	Target Neighborhood Hits	293	Shared Neighborhood Hits	163
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NGEF_HUMAN
NC score	0.256863 (rank : 131)	θ value	0.125558 (rank : 131)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	83
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SPTA1_MOUSE
NC score	0.255935 (rank : 132)	θ value	0.00390308 (rank : 81)
Query Neighborhood Hits	229	Target Neighborhood Hits	675	Shared Neighborhood Hits	145
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ASPP1_MOUSE
NC score	0.255157 (rank : 133)	θ value	0.125558 (rank : 129)
Query Neighborhood Hits	229	Target Neighborhood Hits	1244	Shared Neighborhood Hits	155
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.254935 (rank : 134)	θ value	0.62314 (rank : 155)
Query Neighborhood Hits	229	Target Neighborhood Hits	956	Shared Neighborhood Hits	150
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NGEF_MOUSE
NC score	0.253968 (rank : 135)	θ value	0.163984 (rank : 138)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

EPS8_MOUSE
NC score	0.253152 (rank : 136)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	112
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

NOXO1_HUMAN
NC score	0.251921 (rank : 137)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	229	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

EPS8_HUMAN
NC score	0.251915 (rank : 138)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	99
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SHLB1_MOUSE
NC score	0.246747 (rank : 139)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB1_HUMAN
NC score	0.245038 (rank : 140)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	229	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ES8L1_MOUSE
NC score	0.242098 (rank : 141)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	229	Target Neighborhood Hits	143	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

IASPP_MOUSE
NC score	0.237698 (rank : 142)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	229	Target Neighborhood Hits	1024	Shared Neighborhood Hits	147
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TCGAP_MOUSE
NC score	0.236214 (rank : 143)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	229	Target Neighborhood Hits	409	Shared Neighborhood Hits	121
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ES8L1_HUMAN
NC score	0.235560 (rank : 144)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	229	Target Neighborhood Hits	162	Shared Neighborhood Hits	92
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ARHGG_MOUSE
NC score	0.233080 (rank : 145)	θ value	0.0431538 (rank : 113)
Query Neighborhood Hits	229	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

STS2_HUMAN
NC score	0.230375 (rank : 146)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	229	Target Neighborhood Hits	108	Shared Neighborhood Hits	83
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SHLB2_MOUSE
NC score	0.221188 (rank : 147)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	229	Target Neighborhood Hits	88	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SPN90_HUMAN
NC score	0.220367 (rank : 148)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SHLB2_HUMAN
NC score	0.219605 (rank : 149)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	229	Target Neighborhood Hits	86	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RUSC2_HUMAN
NC score	0.213482 (rank : 150)	θ value	0.0113563 (rank : 96)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TCGAP_HUMAN
NC score	0.212084 (rank : 151)	θ value	0.813845 (rank : 167)
Query Neighborhood Hits	229	Target Neighborhood Hits	872	Shared Neighborhood Hits	124
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STS1_HUMAN
NC score	0.207990 (rank : 152)	θ value	0.47712 (rank : 153)
Query Neighborhood Hits	229	Target Neighborhood Hits	106	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHGG_HUMAN
NC score	0.205784 (rank : 153)	θ value	0.62314 (rank : 154)
Query Neighborhood Hits	229	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

STS1_MOUSE
NC score	0.204869 (rank : 154)	θ value	0.813845 (rank : 166)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ASPP2_HUMAN
NC score	0.201880 (rank : 155)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	229	Target Neighborhood Hits	1156	Shared Neighborhood Hits	141
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AMPH_HUMAN
NC score	0.199056 (rank : 156)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	229	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SHAN2_MOUSE
NC score	0.198595 (rank : 157)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	229	Target Neighborhood Hits	446	Shared Neighborhood Hits	108
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP2_HUMAN
NC score	0.198475 (rank : 158)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	229	Target Neighborhood Hits	139	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

RUSC2_MOUSE
NC score	0.196307 (rank : 159)	θ value	0.0148317 (rank : 101)
Query Neighborhood Hits	229	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SLAP2_MOUSE
NC score	0.194240 (rank : 160)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	229	Target Neighborhood Hits	136	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_MOUSE
NC score	0.192346 (rank : 161)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SNX9_HUMAN
NC score	0.191003 (rank : 162)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	229	Target Neighborhood Hits	148	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

AMPH_MOUSE
NC score	0.190872 (rank : 163)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	229	Target Neighborhood Hits	291	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

P85A_MOUSE
NC score	0.189944 (rank : 164)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	229	Target Neighborhood Hits	435	Shared Neighborhood Hits	106
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BIN1_MOUSE
NC score	0.184700 (rank : 165)	θ value	0.813845 (rank : 158)
Query Neighborhood Hits	229	Target Neighborhood Hits	283	Shared Neighborhood Hits	76
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BIN1_HUMAN
NC score	0.183464 (rank : 166)	θ value	0.813845 (rank : 157)
Query Neighborhood Hits	229	Target Neighborhood Hits	335	Shared Neighborhood Hits	72
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

P85A_HUMAN
NC score	0.181895 (rank : 167)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	229	Target Neighborhood Hits	479	Shared Neighborhood Hits	102
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

FYN_MOUSE
NC score	0.179399 (rank : 168)	θ value	0.813845 (rank : 162)
Query Neighborhood Hits	229	Target Neighborhood Hits	1073	Shared Neighborhood Hits	173
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGR_HUMAN
NC score	0.177070 (rank : 169)	θ value	0.279714 (rank : 142)
Query Neighborhood Hits	229	Target Neighborhood Hits	1067	Shared Neighborhood Hits	166
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
NC score	0.176480 (rank : 170)	θ value	0.813845 (rank : 161)
Query Neighborhood Hits	229	Target Neighborhood Hits	1078	Shared Neighborhood Hits	173
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.176387 (rank : 171)	θ value	0.125558 (rank : 133)
Query Neighborhood Hits	229	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3KL4_HUMAN
NC score	0.176386 (rank : 172)	θ value	0.0148317 (rank : 100)
Query Neighborhood Hits	229	Target Neighborhood Hits	1087	Shared Neighborhood Hits	157
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SLAP1_HUMAN
NC score	0.175133 (rank : 173)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	229	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

YES_HUMAN
NC score	0.174452 (rank : 174)	θ value	0.163984 (rank : 139)
Query Neighborhood Hits	229	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP1_MOUSE
NC score	0.173307 (rank : 175)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SHAN1_HUMAN
NC score	0.171335 (rank : 176)	θ value	0.0330416 (rank : 111)
Query Neighborhood Hits	229	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

FGR_MOUSE
NC score	0.169492 (rank : 177)	θ value	1.38821 (rank : 177)
Query Neighborhood Hits	229	Target Neighborhood Hits	1069	Shared Neighborhood Hits	167
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.168744 (rank : 178)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	229	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

RIMB1_MOUSE
NC score	0.168576 (rank : 179)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	229	Target Neighborhood Hits	1376	Shared Neighborhood Hits	143
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DOCK1_HUMAN
NC score	0.167361 (rank : 180)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	229	Target Neighborhood Hits	191	Shared Neighborhood Hits	108
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

RIMB1_HUMAN
NC score	0.167356 (rank : 181)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	229	Target Neighborhood Hits	1479	Shared Neighborhood Hits	128
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PKHG1_HUMAN
NC score	0.166198 (rank : 182)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG3_HUMAN
NC score	0.165996 (rank : 183)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	229	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.165560 (rank : 184)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	229	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SNX9_MOUSE
NC score	0.163756 (rank : 185)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	229	Target Neighborhood Hits	141	Shared Neighborhood Hits	77
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ARHG8_MOUSE
NC score	0.162664 (rank : 186)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	229	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

M3K11_HUMAN
NC score	0.162461 (rank : 187)	θ value	0.00869519 (rank : 93)
Query Neighborhood Hits	229	Target Neighborhood Hits	1136	Shared Neighborhood Hits	161
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PREX1_HUMAN
NC score	0.161103 (rank : 188)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CIP4_HUMAN
NC score	0.160775 (rank : 189)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	229	Target Neighborhood Hits	374	Shared Neighborhood Hits	69
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

HCK_MOUSE
NC score	0.159417 (rank : 190)	θ value	0.000121331 (rank : 42)
Query Neighborhood Hits	229	Target Neighborhood Hits	1029	Shared Neighborhood Hits	156
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

M3K9_HUMAN
NC score	0.159414 (rank : 191)	θ value	0.00665767 (rank : 91)
Query Neighborhood Hits	229	Target Neighborhood Hits	1123	Shared Neighborhood Hits	157
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

BTK_HUMAN
NC score	0.159296 (rank : 192)	θ value	0.0961366 (rank : 127)
Query Neighborhood Hits	229	Target Neighborhood Hits	1026	Shared Neighborhood Hits	162
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

TIAM1_MOUSE
NC score	0.158074 (rank : 193)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	27
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

P85B_HUMAN
NC score	0.157258 (rank : 194)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	229	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MCF2L_MOUSE
NC score	0.157220 (rank : 195)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	229	Target Neighborhood Hits	255	Shared Neighborhood Hits	50
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

HCK_HUMAN
NC score	0.155923 (rank : 196)	θ value	0.0193708 (rank : 106)
Query Neighborhood Hits	229	Target Neighborhood Hits	1035	Shared Neighborhood Hits	157
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TIAM1_HUMAN
NC score	0.155435 (rank : 197)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

EM55_HUMAN
NC score	0.155326 (rank : 198)	θ value	1.06291 (rank : 171)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

ARHG8_HUMAN
NC score	0.154915 (rank : 199)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	229	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BTK_MOUSE
NC score	0.154424 (rank : 200)	θ value	0.0431538 (rank : 115)
Query Neighborhood Hits	229	Target Neighborhood Hits	1017	Shared Neighborhood Hits	151
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SLY_MOUSE
NC score	0.152450 (rank : 201)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	229	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

EM55_MOUSE
NC score	0.151404 (rank : 202)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	229	Target Neighborhood Hits	221	Shared Neighborhood Hits	87
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

P85B_MOUSE
NC score	0.151232 (rank : 203)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	229	Target Neighborhood Hits	519	Shared Neighborhood Hits	78
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RASA1_HUMAN
NC score	0.149950 (rank : 204)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	229	Target Neighborhood Hits	258	Shared Neighborhood Hits	68
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LYN_HUMAN
NC score	0.146849 (rank : 205)	θ value	0.00228821 (rank : 68)
Query Neighborhood Hits	229	Target Neighborhood Hits	1022	Shared Neighborhood Hits	140
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FRK_HUMAN
NC score	0.145901 (rank : 206)	θ value	0.0961366 (rank : 128)
Query Neighborhood Hits	229	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_MOUSE
NC score	0.145563 (rank : 207)	θ value	0.00298849 (rank : 73)
Query Neighborhood Hits	229	Target Neighborhood Hits	1023	Shared Neighborhood Hits	137
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SRC_MOUSE
NC score	0.144886 (rank : 208)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	229	Target Neighborhood Hits	1033	Shared Neighborhood Hits	144
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

JIP2_MOUSE
NC score	0.144471 (rank : 209)	θ value	2.36792 (rank : 193)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

M3K10_HUMAN
NC score	0.141553 (rank : 210)	θ value	0.0148317 (rank : 99)
Query Neighborhood Hits	229	Target Neighborhood Hits	1071	Shared Neighborhood Hits	138
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

JIP2_HUMAN
NC score	0.140690 (rank : 211)	θ value	2.36792 (rank : 192)
Query Neighborhood Hits	229	Target Neighborhood Hits	288	Shared Neighborhood Hits	56
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

BLK_HUMAN
NC score	0.137229 (rank : 212)	θ value	0.813845 (rank : 159)
Query Neighborhood Hits	229	Target Neighborhood Hits	994	Shared Neighborhood Hits	127
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ARHGF_HUMAN
NC score	0.136931 (rank : 213)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	229	Target Neighborhood Hits	214	Shared Neighborhood Hits	25
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

JIP1_MOUSE
NC score	0.136761 (rank : 214)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	229	Target Neighborhood Hits	259	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.136618 (rank : 215)	θ value	1.06291 (rank : 173)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

BLK_MOUSE
NC score	0.134494 (rank : 216)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	229	Target Neighborhood Hits	992	Shared Neighborhood Hits	117
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SLY_HUMAN
NC score	0.133720 (rank : 217)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	229	Target Neighborhood Hits	81	Shared Neighborhood Hits	51
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

BI2L1_HUMAN
NC score	0.132464 (rank : 218)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

TTC6_HUMAN
NC score	0.131843 (rank : 219)	θ value	0.000158464 (rank : 48)
Query Neighborhood Hits	229	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q86TZ1, Q96CE6	Gene names	TTC6
Domain Architecture
Description	Tetratricopeptide repeat protein 6 (TPR repeat protein 6).

ECT2_MOUSE
NC score	0.131544 (rank : 220)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	229	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_MOUSE
NC score	0.131327 (rank : 221)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	229	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MCF2_HUMAN
NC score	0.129420 (rank : 222)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	30
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

TXK_MOUSE
NC score	0.128117 (rank : 223)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	229	Target Neighborhood Hits	980	Shared Neighborhood Hits	129
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ECT2_HUMAN
NC score	0.127495 (rank : 224)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	229	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHGA_HUMAN
NC score	0.127190 (rank : 225)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	229	Target Neighborhood Hits	187	Shared Neighborhood Hits	23
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

DAPP1_MOUSE
NC score	0.126558 (rank : 226)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MPP6_HUMAN
NC score	0.125504 (rank : 227)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	229	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

ARHG1_HUMAN
NC score	0.124689 (rank : 228)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	229	Target Neighborhood Hits	176	Shared Neighborhood Hits	22
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

P55G_HUMAN
NC score	0.124631 (rank : 229)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	229	Target Neighborhood Hits	451	Shared Neighborhood Hits	58
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.124543 (rank : 230)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	229	Target Neighborhood Hits	401	Shared Neighborhood Hits	57
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CSK_MOUSE
NC score	0.124328 (rank : 231)	θ value	1.81305 (rank : 183)
Query Neighborhood Hits	229	Target Neighborhood Hits	1009	Shared Neighborhood Hits	120
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
NC score	0.124287 (rank : 232)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CSK_HUMAN
NC score	0.124137 (rank : 233)	θ value	1.81305 (rank : 182)
Query Neighborhood Hits	229	Target Neighborhood Hits	1009	Shared Neighborhood Hits	120
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

LCK_HUMAN
NC score	0.123113 (rank : 234)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	229	Target Neighborhood Hits	987	Shared Neighborhood Hits	108
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

ARHGB_HUMAN
NC score	0.122340 (rank : 235)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	229	Target Neighborhood Hits	375	Shared Neighborhood Hits	33
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SH21B_MOUSE
NC score	0.122065 (rank : 236)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

LCK_MOUSE
NC score	0.121979 (rank : 237)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	229	Target Neighborhood Hits	981	Shared Neighborhood Hits	107
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MPP6_MOUSE
NC score	0.121713 (rank : 238)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	229	Target Neighborhood Hits	187	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

ARHGC_MOUSE
NC score	0.121548 (rank : 239)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	229	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TEC_HUMAN
NC score	0.121459 (rank : 240)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	229	Target Neighborhood Hits	1006	Shared Neighborhood Hits	127
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHGC_HUMAN
NC score	0.121335 (rank : 241)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	229	Target Neighborhood Hits	351	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SH21B_HUMAN
NC score	0.120866 (rank : 242)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	229	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_HUMAN
NC score	0.120263 (rank : 243)	θ value	0.279714 (rank : 143)
Query Neighborhood Hits	229	Target Neighborhood Hits	971	Shared Neighborhood Hits	114
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

PTK6_MOUSE
NC score	0.119330 (rank : 244)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	229	Target Neighborhood Hits	1026	Shared Neighborhood Hits	143
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TEC_MOUSE
NC score	0.118196 (rank : 245)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	229	Target Neighborhood Hits	1006	Shared Neighborhood Hits	125
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.116966 (rank : 246)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	229	Target Neighborhood Hits	1020	Shared Neighborhood Hits	146
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BAIP2_MOUSE
NC score	0.115303 (rank : 247)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	229	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

ABL1_HUMAN
NC score	0.114814 (rank : 248)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	229	Target Neighborhood Hits	1220	Shared Neighborhood Hits	117
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.114116 (rank : 249)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	229	Target Neighborhood Hits	1178	Shared Neighborhood Hits	114
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BAIP2_HUMAN
NC score	0.112599 (rank : 250)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	229	Target Neighborhood Hits	192	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ABL2_HUMAN
NC score	0.112474 (rank : 251)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	229	Target Neighborhood Hits	1045	Shared Neighborhood Hits	107
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ITK_HUMAN
NC score	0.111199 (rank : 252)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	229	Target Neighborhood Hits	1016	Shared Neighborhood Hits	121
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BCR_HUMAN
NC score	0.111011 (rank : 253)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	37
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

LBC_HUMAN
NC score	0.109323 (rank : 254)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	229	Target Neighborhood Hits	90	Shared Neighborhood Hits	21
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG1_MOUSE
NC score	0.109238 (rank : 255)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	229	Target Neighborhood Hits	266	Shared Neighborhood Hits	18
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RGNEF_MOUSE
NC score	0.108794 (rank : 256)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	229	Target Neighborhood Hits	641	Shared Neighborhood Hits	37
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

GRB14_MOUSE
NC score	0.108489 (rank : 257)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	229	Target Neighborhood Hits	149	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HAPIP_HUMAN
NC score	0.108480 (rank : 258)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	229	Target Neighborhood Hits	350	Shared Neighborhood Hits	29
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHG2_HUMAN
NC score	0.108057 (rank : 259)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	229	Target Neighborhood Hits	142	Shared Neighborhood Hits	25
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

SHE_MOUSE
NC score	0.108026 (rank : 260)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	229	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MPP5_HUMAN
NC score	0.107657 (rank : 261)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	229	Target Neighborhood Hits	231	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

GNRP_MOUSE
NC score	0.107642 (rank : 262)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	229	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG2_MOUSE
NC score	0.107300 (rank : 263)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	229	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

SHC3_MOUSE
NC score	0.106833 (rank : 264)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

MPP5_MOUSE
NC score	0.106526 (rank : 265)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	229	Target Neighborhood Hits	226	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

FGD3_MOUSE
NC score	0.105675 (rank : 266)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	229	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

GRB14_HUMAN
NC score	0.105300 (rank : 267)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FGD4_MOUSE
NC score	0.103668 (rank : 268)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

HSH2D_HUMAN
NC score	0.103639 (rank : 269)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	229	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ITK_MOUSE
NC score	0.103475 (rank : 270)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	229	Target Neighborhood Hits	985	Shared Neighborhood Hits	110
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SHB_MOUSE
NC score	0.103446 (rank : 271)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

FGD4_HUMAN
NC score	0.103371 (rank : 272)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	229	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

BI2L1_MOUSE
NC score	0.103229 (rank : 273)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	229	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

APS_HUMAN
NC score	0.102749 (rank : 274)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	229	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SHE_HUMAN
NC score	0.102449 (rank : 275)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	229	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHC1_MOUSE
NC score	0.102335 (rank : 276)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	229	Target Neighborhood Hits	180	Shared Neighborhood Hits	54
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHD_MOUSE
NC score	0.102277 (rank : 277)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	229	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC1_HUMAN
NC score	0.101543 (rank : 278)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	229	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_HUMAN
NC score	0.101231 (rank : 279)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	229	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHB_HUMAN
NC score	0.100675 (rank : 280)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	229	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PPIP2_HUMAN
NC score	0.100591 (rank : 281)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	229	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

FGD3_HUMAN
NC score	0.100332 (rank : 282)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	229	Target Neighborhood Hits	249	Shared Neighborhood Hits	24
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.099693 (rank : 283)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	26
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

SHD_HUMAN
NC score	0.099478 (rank : 284)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHC2_HUMAN
NC score	0.098536 (rank : 285)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	229	Target Neighborhood Hits	170	Shared Neighborhood Hits	48
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

ABR_HUMAN
NC score	0.098201 (rank : 286)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	229	Target Neighborhood Hits	166	Shared Neighborhood Hits	36
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

SHC2_MOUSE
NC score	0.097915 (rank : 287)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GNRP_HUMAN
NC score	0.097607 (rank : 288)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	229	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

CHIN_MOUSE
NC score	0.096998 (rank : 289)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	229	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SRMS_MOUSE
NC score	0.095597 (rank : 290)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	229	Target Neighborhood Hits	964	Shared Neighborhood Hits	95
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CHIO_HUMAN
NC score	0.095519 (rank : 291)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	229	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.095356 (rank : 292)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LNK_HUMAN
NC score	0.094538 (rank : 293)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	229	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGD2_MOUSE
NC score	0.094229 (rank : 294)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	229	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

LNK_MOUSE
NC score	0.093662 (rank : 295)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	229	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

GRB7_MOUSE
NC score	0.092523 (rank : 296)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	229	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

MPP2_HUMAN
NC score	0.090898 (rank : 297)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	229	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

PPIP2_MOUSE
NC score	0.090399 (rank : 298)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	229	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

MPP2_MOUSE
NC score	0.090351 (rank : 299)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	229	Target Neighborhood Hits	189	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

FGD1_HUMAN
NC score	0.089654 (rank : 300)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	229	Target Neighborhood Hits	367	Shared Neighborhood Hits	30
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SASH1_HUMAN
NC score	0.088344 (rank : 301)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	229	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

RHG09_HUMAN
NC score	0.087487 (rank : 302)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	229	Target Neighborhood Hits	186	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

MPP4_MOUSE
NC score	0.087443 (rank : 303)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	229	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

FGD1_MOUSE
NC score	0.087352 (rank : 304)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	229	Target Neighborhood Hits	387	Shared Neighborhood Hits	28
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SRMS_HUMAN
NC score	0.086351 (rank : 305)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	229	Target Neighborhood Hits	946	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FUT8_HUMAN
NC score	0.084682 (rank : 306)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	229	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FARP2_MOUSE
NC score	0.084144 (rank : 307)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	229	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_MOUSE
NC score	0.083869 (rank : 308)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	229	Target Neighborhood Hits	282	Shared Neighborhood Hits	26
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

GRB10_MOUSE
NC score	0.083399 (rank : 309)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB7_HUMAN
NC score	0.083248 (rank : 310)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	229	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SAMN1_HUMAN
NC score	0.083167 (rank : 311)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	229	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

MATK_MOUSE
NC score	0.082919 (rank : 312)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	229	Target Neighborhood Hits	952	Shared Neighborhood Hits	77
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MATK_HUMAN
NC score	0.081729 (rank : 313)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	229	Target Neighborhood Hits	954	Shared Neighborhood Hits	75
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

GRB10_HUMAN
NC score	0.081668 (rank : 314)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	229	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

MPP4_HUMAN
NC score	0.081628 (rank : 315)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

SASH1_MOUSE
NC score	0.081561 (rank : 316)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	229	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

DLG2_HUMAN
NC score	0.081062 (rank : 317)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	229	Target Neighborhood Hits	279	Shared Neighborhood Hits	70
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PTN11_MOUSE
NC score	0.080772 (rank : 318)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.080760 (rank : 319)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	229	Target Neighborhood Hits	227	Shared Neighborhood Hits	49
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

DLG2_MOUSE
NC score	0.080704 (rank : 320)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	229	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

FUT8_MOUSE
NC score	0.080163 (rank : 321)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	229	Target Neighborhood Hits	115	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SH21A_MOUSE
NC score	0.080059 (rank : 322)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	229	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

DLG4_HUMAN
NC score	0.079593 (rank : 323)	θ value	1.81305 (rank : 185)
Query Neighborhood Hits	229	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

FGD6_HUMAN
NC score	0.079086 (rank : 324)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	229	Target Neighborhood Hits	237	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

SH21A_HUMAN
NC score	0.078972 (rank : 325)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	229	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

APS_MOUSE
NC score	0.078935 (rank : 326)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	229	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH22A_MOUSE
NC score	0.078873 (rank : 327)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	229	Target Neighborhood Hits	179	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

RHG12_MOUSE
NC score	0.078341 (rank : 328)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DLG3_HUMAN
NC score	0.077901 (rank : 329)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	67
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

SAMN1_MOUSE
NC score	0.077463 (rank : 330)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	229	Target Neighborhood Hits	69	Shared Neighborhood Hits	37
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

DLG3_MOUSE
NC score	0.077459 (rank : 331)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	229	Target Neighborhood Hits	274	Shared Neighborhood Hits	67
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

SH2D3_MOUSE
NC score	0.077054 (rank : 332)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

DLG1_HUMAN
NC score	0.076087 (rank : 333)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	229	Target Neighborhood Hits	290	Shared Neighborhood Hits	62
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

FARP2_HUMAN
NC score	0.075235 (rank : 334)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	229	Target Neighborhood Hits	240	Shared Neighborhood Hits	25
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SOCS7_MOUSE
NC score	0.075220 (rank : 335)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	229	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

DLG4_MOUSE
NC score	0.075209 (rank : 336)	θ value	2.36792 (rank : 190)
Query Neighborhood Hits	229	Target Neighborhood Hits	282	Shared Neighborhood Hits	66
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

LCP2_MOUSE
NC score	0.074879 (rank : 337)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	229	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BCAR3_HUMAN
NC score	0.074861 (rank : 338)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	229	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

CDC27_HUMAN
NC score	0.074613 (rank : 339)	θ value	0.279714 (rank : 141)
Query Neighborhood Hits	229	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	P30260, Q16349, Q96F35	Gene names	CDC27
Domain Architecture
Description	Cell division cycle protein 27 homolog (CDC27Hs) (H-NUC).

PKHG4_HUMAN
NC score	0.074360 (rank : 340)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	229	Target Neighborhood Hits	200	Shared Neighborhood Hits	19
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FARP1_HUMAN
NC score	0.074241 (rank : 341)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	229	Target Neighborhood Hits	241	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

IFT88_HUMAN
NC score	0.073567 (rank : 342)	θ value	0.163984 (rank : 137)
Query Neighborhood Hits	229	Target Neighborhood Hits	122	Shared Neighborhood Hits	12
SwissProt Accessions	Q13099	Gene names	IFT88, TG737, TTC10
Domain Architecture
Description	Intraflagellar transport 88 homolog (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (Recessive polycystic kidney disease protein Tg737 homolog).

TRIO_HUMAN
NC score	0.073533 (rank : 343)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	229	Target Neighborhood Hits	1580	Shared Neighborhood Hits	86
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

BCAR3_MOUSE
NC score	0.073243 (rank : 344)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	229	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

RHG12_HUMAN
NC score	0.073218 (rank : 345)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	229	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DLG1_MOUSE
NC score	0.073022 (rank : 346)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	229	Target Neighborhood Hits	285	Shared Neighborhood Hits	58
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

SH24A_HUMAN
NC score	0.072724 (rank : 347)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	229	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

FER_HUMAN
NC score	0.071349 (rank : 348)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	229	Target Neighborhood Hits	1278	Shared Neighborhood Hits	68
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

PTN6_MOUSE
NC score	0.070987 (rank : 349)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SH2D3_HUMAN
NC score	0.070948 (rank : 350)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	229	Target Neighborhood Hits	188	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

PTN6_HUMAN
NC score	0.069889 (rank : 351)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	229	Target Neighborhood Hits	234	Shared Neighborhood Hits	52
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

CSKP_MOUSE
NC score	0.069016 (rank : 352)	θ value	0.0736092 (rank : 122)
Query Neighborhood Hits	229	Target Neighborhood Hits	1027	Shared Neighborhood Hits	110
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CSKP_HUMAN
NC score	0.068940 (rank : 353)	θ value	0.163984 (rank : 136)
Query Neighborhood Hits	229	Target Neighborhood Hits	1022	Shared Neighborhood Hits	103
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

SH23A_HUMAN
NC score	0.067852 (rank : 354)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	229	Target Neighborhood Hits	149	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

BBS4_MOUSE
NC score	0.067661 (rank : 355)	θ value	0.47712 (rank : 150)
Query Neighborhood Hits	229	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C1Z7, Q3UYF0, Q8CA57	Gene names	Bbs4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein homolog.

LCP2_HUMAN
NC score	0.067490 (rank : 356)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	229	Target Neighborhood Hits	531	Shared Neighborhood Hits	43
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SH22A_HUMAN
NC score	0.067488 (rank : 357)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	229	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

CHIO_MOUSE
NC score	0.066993 (rank : 358)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	229	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

REPS2_HUMAN
NC score	0.065809 (rank : 359)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	229	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

ZAP70_MOUSE
NC score	0.065646 (rank : 360)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	229	Target Neighborhood Hits	905	Shared Neighborhood Hits	54
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

HSH2D_MOUSE
NC score	0.065641 (rank : 361)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	229	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

KSYK_MOUSE
NC score	0.065341 (rank : 362)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	229	Target Neighborhood Hits	944	Shared Neighborhood Hits	56
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_HUMAN
NC score	0.065193 (rank : 363)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	229	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

REPS2_MOUSE
NC score	0.065096 (rank : 364)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	229	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

INVO_MOUSE
NC score	0.064546 (rank : 365)	θ value	0.0193708 (rank : 107)
Query Neighborhood Hits	229	Target Neighborhood Hits	474	Shared Neighborhood Hits	12
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

BMX_MOUSE
NC score	0.064533 (rank : 366)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	229	Target Neighborhood Hits	912	Shared Neighborhood Hits	50
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BMX_HUMAN
NC score	0.064483 (rank : 367)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	229	Target Neighborhood Hits	942	Shared Neighborhood Hits	52
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

KSYK_HUMAN
NC score	0.063709 (rank : 368)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	229	Target Neighborhood Hits	901	Shared Neighborhood Hits	54
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MPP3_HUMAN
NC score	0.063374 (rank : 369)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	229	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
NC score	0.063192 (rank : 370)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	229	Target Neighborhood Hits	165	Shared Neighborhood Hits	33
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

CRSP3_HUMAN
NC score	0.062823 (rank : 371)	θ value	0.163984 (rank : 135)
Query Neighborhood Hits	229	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULK4, O95403, Q9H0J2, Q9NTT9, Q9NTU0, Q9Y5P7, Q9Y667	Gene names	CRSP3, ARC130, DRIP130, KIAA1216, SUR2
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 3 (Cofactor required for Sp1 transcriptional activation subunit 3) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) (Activator-recruited cofactor 130 kDa component) (ARC130).

IFT88_MOUSE
NC score	0.062227 (rank : 372)	θ value	1.38821 (rank : 178)
Query Neighborhood Hits	229	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	Q61371	Gene names	Ift88, Tg737, Tg737Rpw, TgN737Rpw, Ttc10
Domain Architecture
Description	Intraflagellar transport 88 homolog (Tetratricopeptide repeat protein 10) (TPR repeat protein 10) (Recessive polycystic kidney disease protein Tg737) (TgN(Imorpk)737Rpw).

ACK1_MOUSE
NC score	0.061971 (rank : 373)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	229	Target Neighborhood Hits	1080	Shared Neighborhood Hits	75
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACK1_HUMAN
NC score	0.060703 (rank : 374)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	229	Target Neighborhood Hits	1140	Shared Neighborhood Hits	69
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

3BP1_HUMAN
NC score	0.060455 (rank : 375)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	229	Target Neighborhood Hits	376	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DNJC7_HUMAN
NC score	0.060047 (rank : 376)	θ value	0.0193708 (rank : 105)
Query Neighborhood Hits	229	Target Neighborhood Hits	212	Shared Neighborhood Hits	17
SwissProt Accessions	Q99615	Gene names	DNAJC7, TPR2, TTC2
Domain Architecture
Description	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2).

DUET_HUMAN
NC score	0.059716 (rank : 377)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	229	Target Neighborhood Hits	1220	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

BBS4_HUMAN
NC score	0.059611 (rank : 378)	θ value	3.0926 (rank : 196)
Query Neighborhood Hits	229	Target Neighborhood Hits	109	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RK4, Q8NHU9, Q96H45	Gene names	BBS4
Domain Architecture
Description	Bardet-Biedl syndrome 4 protein.

TOM1_HUMAN
NC score	0.059428 (rank : 379)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	229	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

TOM1_MOUSE
NC score	0.059043 (rank : 380)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	229	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

DNJC7_MOUSE
NC score	0.057899 (rank : 381)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	229	Target Neighborhood Hits	211	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QYI3, Q3TKR1, Q8BPG3, Q8CIL2, Q9CT29, Q9D026	Gene names	Dnajc7, Ttc2
Domain Architecture
Description	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2) (MDj11).

TEX14_MOUSE
NC score	0.057330 (rank : 382)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	229	Target Neighborhood Hits	1333	Shared Neighborhood Hits	43
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

OPHN1_HUMAN
NC score	0.057076 (rank : 383)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	229	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

DOCK2_MOUSE
NC score	0.056898 (rank : 384)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

BLNK_MOUSE
NC score	0.056775 (rank : 385)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	229	Target Neighborhood Hits	296	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

TEX14_HUMAN
NC score	0.055955 (rank : 386)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	229	Target Neighborhood Hits	1103	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

SOCS6_HUMAN
NC score	0.055838 (rank : 387)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	229	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.055728 (rank : 388)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	229	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS2_MOUSE
NC score	0.055314 (rank : 389)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	229	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

ILK_MOUSE
NC score	0.054720 (rank : 390)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	229	Target Neighborhood Hits	858	Shared Neighborhood Hits	39
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK1_HUMAN
NC score	0.054491 (rank : 391)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	229	Target Neighborhood Hits	857	Shared Neighborhood Hits	39
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

OPHN1_MOUSE
NC score	0.054467 (rank : 392)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	229	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

ILK2_HUMAN
NC score	0.054074 (rank : 393)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	229	Target Neighborhood Hits	848	Shared Neighborhood Hits	39
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

REPS1_HUMAN
NC score	0.053885 (rank : 394)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	229	Target Neighborhood Hits	205	Shared Neighborhood Hits	7
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

HGS_HUMAN
NC score	0.053519 (rank : 395)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	229	Target Neighborhood Hits	517	Shared Neighborhood Hits	15
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.053474 (rank : 396)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	229	Target Neighborhood Hits	589	Shared Neighborhood Hits	18
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

SOS1_HUMAN
NC score	0.053391 (rank : 397)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	229	Target Neighborhood Hits	274	Shared Neighborhood Hits	19
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

F10A1_MOUSE
NC score	0.053111 (rank : 398)	θ value	1.81305 (rank : 186)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	Q99L47, Q4FJT4	Gene names	St13, Fam10a1, Hip
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Protein ST13 homolog) (Protein FAM10A1).

SYEP_HUMAN
NC score	0.053010 (rank : 399)	θ value	0.365318 (rank : 149)
Query Neighborhood Hits	229	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

DOCK2_HUMAN
NC score	0.052895 (rank : 400)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	229	Target Neighborhood Hits	90	Shared Neighborhood Hits	40
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DDFL1_HUMAN
NC score	0.052746 (rank : 401)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	229	Target Neighborhood Hits	353	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

SOCS2_HUMAN
NC score	0.052707 (rank : 402)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	229	Target Neighborhood Hits	104	Shared Neighborhood Hits	33
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

FES_HUMAN
NC score	0.052621 (rank : 403)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	229	Target Neighborhood Hits	978	Shared Neighborhood Hits	49
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TENS4_MOUSE
NC score	0.052289 (rank : 404)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	229	Target Neighborhood Hits	225	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TENS4_HUMAN
NC score	0.052225 (rank : 405)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	229	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

BLNK_HUMAN
NC score	0.052187 (rank : 406)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	229	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

REPS1_MOUSE
NC score	0.052098 (rank : 407)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	229	Target Neighborhood Hits	204	Shared Neighborhood Hits	5
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

DDFL1_MOUSE
NC score	0.051748 (rank : 408)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	229	Target Neighborhood Hits	324	Shared Neighborhood Hits	10
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

SH24A_MOUSE
NC score	0.051578 (rank : 409)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	229	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

EP15_MOUSE
NC score	0.050121 (rank : 410)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	229	Target Neighborhood Hits	820	Shared Neighborhood Hits	21
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

F10A1_HUMAN
NC score	0.049693 (rank : 411)	θ value	1.38821 (rank : 176)
Query Neighborhood Hits	229	Target Neighborhood Hits	312	Shared Neighborhood Hits	15
SwissProt Accessions	P50502, O14999	Gene names	ST13, FAM10A1, HIP, SNC6
Domain Architecture
Description	Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 13) (Putative tumor suppressor ST13) (Protein FAM10A1) (Progesterone receptor-associated p48 protein) (NY-REN-33 antigen).

SYEP_MOUSE
NC score	0.049030 (rank : 412)	θ value	1.81305 (rank : 187)
Query Neighborhood Hits	229	Target Neighborhood Hits	123	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

F10A4_HUMAN
NC score	0.048931 (rank : 413)	θ value	2.36792 (rank : 191)
Query Neighborhood Hits	229	Target Neighborhood Hits	249	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IZP2	Gene names	FAM10A4
Domain Architecture	No domain graphic available
Description	Protein FAM10A4.

F10A5_HUMAN
NC score	0.048927 (rank : 414)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	229	Target Neighborhood Hits	277	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NFI4	Gene names	FAM10A5
Domain Architecture	No domain graphic available
Description	Protein FAM10A5.

TTC13_HUMAN
NC score	0.048449 (rank : 415)	θ value	8.99809 (rank : 228)
Query Neighborhood Hits	229	Target Neighborhood Hits	117	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NBP0, Q8IVP8, Q8NBI0, Q8ND20	Gene names	TTC13
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 13 (TPR repeat protein 13).

CD017_HUMAN
NC score	0.042854 (rank : 416)	θ value	1.38821 (rank : 175)
Query Neighborhood Hits	229	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q53FE4, Q6FI84, Q6IS77, Q9H0D9	Gene names	C4orf17
Domain Architecture	No domain graphic available
Description	Protein C4orf17.

GPS2_HUMAN
NC score	0.042154 (rank : 417)	θ value	3.0926 (rank : 197)
Query Neighborhood Hits	229	Target Neighborhood Hits	459	Shared Neighborhood Hits	11
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

K0372_HUMAN
NC score	0.038489 (rank : 418)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	229	Target Neighborhood Hits	136	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PGP7, O15077, Q6PJI3	Gene names	KIAA0372
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein KIAA0372 (TPR repeat protein KIAA0372).

GOGA3_MOUSE
NC score	0.031565 (rank : 419)	θ value	0.365318 (rank : 147)
Query Neighborhood Hits	229	Target Neighborhood Hits	1437	Shared Neighborhood Hits	34
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

TDRKH_MOUSE
NC score	0.029439 (rank : 420)	θ value	1.38821 (rank : 180)
Query Neighborhood Hits	229	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

RNF17_MOUSE
NC score	0.029209 (rank : 421)	θ value	1.38821 (rank : 179)
Query Neighborhood Hits	229	Target Neighborhood Hits	147	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

OM34_HUMAN
NC score	0.028763 (rank : 422)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	229	Target Neighborhood Hits	82	Shared Neighborhood Hits	15
SwissProt Accessions	Q15785, Q9NTZ3	Gene names	TOMM34
Domain Architecture
Description	Mitochondrial import receptor subunit TOM34 (Translocase of outer membrane 34 kDa subunit) (hTom34).

GOGA3_HUMAN
NC score	0.028442 (rank : 423)	θ value	1.06291 (rank : 172)
Query Neighborhood Hits	229	Target Neighborhood Hits	1317	Shared Neighborhood Hits	24
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MYRIP_HUMAN
NC score	0.026487 (rank : 424)	θ value	0.813845 (rank : 163)
Query Neighborhood Hits	229	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ANR38_HUMAN
NC score	0.023717 (rank : 425)	θ value	1.81305 (rank : 181)
Query Neighborhood Hits	229	Target Neighborhood Hits	443	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

TDRKH_HUMAN
NC score	0.022272 (rank : 426)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	229	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

AN30A_HUMAN
NC score	0.021972 (rank : 427)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	229	Target Neighborhood Hits	1119	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

CLUA1_MOUSE
NC score	0.017234 (rank : 428)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	229	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

PTN23_MOUSE
NC score	0.012360 (rank : 429)	θ value	0.813845 (rank : 164)
Query Neighborhood Hits	229	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

NSG2_HUMAN
NC score	0.012327 (rank : 430)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	229	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y328, Q9UHX8	Gene names	NSG2
Domain Architecture
Description	Neuron-specific protein family member 2 (Protein p19) (HMP19).

UBP2L_MOUSE
NC score	0.011375 (rank : 431)	θ value	8.99809 (rank : 229)
Query Neighborhood Hits	229	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

SSH2_MOUSE
NC score	0.011193 (rank : 432)	θ value	2.36792 (rank : 195)
Query Neighborhood Hits	229	Target Neighborhood Hits	119	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

RFIP5_HUMAN
NC score	0.010999 (rank : 433)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	229	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXF6, O94939, Q9P0M1	Gene names	RAB11FIP5, GAF1, KIAA0857, RIP11
Domain Architecture
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75).

TLE1_HUMAN
NC score	0.006342 (rank : 434)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	229	Target Neighborhood Hits	485	Shared Neighborhood Hits	10
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

BOC_HUMAN
NC score	0.005695 (rank : 435)	θ value	0.813845 (rank : 160)
Query Neighborhood Hits	229	Target Neighborhood Hits	543	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).