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Network neighborhood for query Sequence : SASH1_HUMAN

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SASH1_HUMAN
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SASH1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	292	Target Neighborhood Hits	292	Shared Neighborhood Hits	292
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	0 (rank : 2)	NC score	0.951963 (rank : 2)
Query Neighborhood Hits	292	Target Neighborhood Hits	263	Shared Neighborhood Hits	138
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SLY_MOUSE
θ value	6.32992e-62 (rank : 3)	NC score	0.838390 (rank : 4)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLY_HUMAN
θ value	5.92465e-60 (rank : 4)	NC score	0.841303 (rank : 3)
Query Neighborhood Hits	292	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SAMN1_HUMAN
θ value	1.67352e-46 (rank : 5)	NC score	0.820252 (rank : 5)
Query Neighborhood Hits	292	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	5.03882e-43 (rank : 6)	NC score	0.816983 (rank : 6)
Query Neighborhood Hits	292	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ANKS1_HUMAN
θ value	2.44474e-05 (rank : 7)	NC score	0.145889 (rank : 18)
Query Neighborhood Hits	292	Target Neighborhood Hits	438	Shared Neighborhood Hits	58
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0.00035302 (rank : 8)	NC score	0.149689 (rank : 16)
Query Neighborhood Hits	292	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

EPHA4_MOUSE
θ value	0.00035302 (rank : 9)	NC score	0.096263 (rank : 51)
Query Neighborhood Hits	292	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

CD2AP_HUMAN
θ value	0.000461057 (rank : 10)	NC score	0.214843 (rank : 7)
Query Neighborhood Hits	292	Target Neighborhood Hits	315	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

MYO1E_HUMAN
θ value	0.000461057 (rank : 11)	NC score	0.086854 (rank : 81)
Query Neighborhood Hits	292	Target Neighborhood Hits	293	Shared Neighborhood Hits	61
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

EPHA4_HUMAN
θ value	0.000786445 (rank : 12)	NC score	0.095379 (rank : 54)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

IF2P_HUMAN
θ value	0.00134147 (rank : 13)	NC score	0.060850 (rank : 159)
Query Neighborhood Hits	292	Target Neighborhood Hits	889	Shared Neighborhood Hits	29
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

EPHB6_MOUSE
θ value	0.00175202 (rank : 14)	NC score	0.110919 (rank : 35)
Query Neighborhood Hits	292	Target Neighborhood Hits	906	Shared Neighborhood Hits	57
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

CSKI2_MOUSE
θ value	0.00298849 (rank : 15)	NC score	0.123200 (rank : 28)
Query Neighborhood Hits	292	Target Neighborhood Hits	812	Shared Neighborhood Hits	120
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GRAP_HUMAN
θ value	0.00298849 (rank : 16)	NC score	0.150981 (rank : 15)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

EPHA7_MOUSE
θ value	0.00509761 (rank : 17)	NC score	0.093706 (rank : 57)
Query Neighborhood Hits	292	Target Neighborhood Hits	1025	Shared Neighborhood Hits	55
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB6_HUMAN
θ value	0.00509761 (rank : 18)	NC score	0.109130 (rank : 37)
Query Neighborhood Hits	292	Target Neighborhood Hits	912	Shared Neighborhood Hits	58
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

CSKI2_HUMAN
θ value	0.00665767 (rank : 19)	NC score	0.122425 (rank : 29)
Query Neighborhood Hits	292	Target Neighborhood Hits	747	Shared Neighborhood Hits	123
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA7_HUMAN
θ value	0.00665767 (rank : 20)	NC score	0.094116 (rank : 55)
Query Neighborhood Hits	292	Target Neighborhood Hits	1053	Shared Neighborhood Hits	56
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

TPO_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.091564 (rank : 62)
Query Neighborhood Hits	292	Target Neighborhood Hits	258	Shared Neighborhood Hits	41
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TRDN_HUMAN
θ value	0.00869519 (rank : 22)	NC score	0.078468 (rank : 94)
Query Neighborhood Hits	292	Target Neighborhood Hits	542	Shared Neighborhood Hits	29
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

NFH_MOUSE
θ value	0.0113563 (rank : 23)	NC score	0.052870 (rank : 231)
Query Neighborhood Hits	292	Target Neighborhood Hits	2247	Shared Neighborhood Hits	140
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

EPHB1_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.090257 (rank : 64)
Query Neighborhood Hits	292	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

ITSN1_HUMAN
θ value	0.0193708 (rank : 25)	NC score	0.101517 (rank : 43)
Query Neighborhood Hits	292	Target Neighborhood Hits	1757	Shared Neighborhood Hits	119
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3K1_HUMAN
θ value	0.0193708 (rank : 26)	NC score	0.187522 (rank : 8)
Query Neighborhood Hits	292	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

ABL1_MOUSE
θ value	0.0252991 (rank : 27)	NC score	0.065830 (rank : 130)
Query Neighborhood Hits	292	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CRK_MOUSE
θ value	0.0252991 (rank : 28)	NC score	0.183435 (rank : 9)
Query Neighborhood Hits	292	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
θ value	0.0330416 (rank : 29)	NC score	0.178129 (rank : 11)
Query Neighborhood Hits	292	Target Neighborhood Hits	308	Shared Neighborhood Hits	65
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

EPHA6_MOUSE
θ value	0.0330416 (rank : 30)	NC score	0.098625 (rank : 45)
Query Neighborhood Hits	292	Target Neighborhood Hits	946	Shared Neighborhood Hits	52
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ARHG7_HUMAN
θ value	0.0431538 (rank : 31)	NC score	0.143723 (rank : 19)
Query Neighborhood Hits	292	Target Neighborhood Hits	347	Shared Neighborhood Hits	64
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SH3K1_MOUSE
θ value	0.0431538 (rank : 32)	NC score	0.183192 (rank : 10)
Query Neighborhood Hits	292	Target Neighborhood Hits	332	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CSKI1_HUMAN
θ value	0.0563607 (rank : 33)	NC score	0.131138 (rank : 24)
Query Neighborhood Hits	292	Target Neighborhood Hits	997	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.0563607 (rank : 34)	NC score	0.131243 (rank : 23)
Query Neighborhood Hits	292	Target Neighborhood Hits	1031	Shared Neighborhood Hits	161
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EPHA6_HUMAN
θ value	0.0563607 (rank : 35)	NC score	0.098061 (rank : 48)
Query Neighborhood Hits	292	Target Neighborhood Hits	959	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB4_MOUSE
θ value	0.0736092 (rank : 36)	NC score	0.089273 (rank : 66)
Query Neighborhood Hits	292	Target Neighborhood Hits	1013	Shared Neighborhood Hits	56
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

CRKL_HUMAN
θ value	0.0961366 (rank : 37)	NC score	0.171886 (rank : 12)
Query Neighborhood Hits	292	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.0961366 (rank : 38)	NC score	0.171647 (rank : 13)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

VAV_HUMAN
θ value	0.0961366 (rank : 39)	NC score	0.125313 (rank : 26)
Query Neighborhood Hits	292	Target Neighborhood Hits	452	Shared Neighborhood Hits	63
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DRD4_HUMAN
θ value	0.125558 (rank : 40)	NC score	0.008401 (rank : 406)
Query Neighborhood Hits	292	Target Neighborhood Hits	886	Shared Neighborhood Hits	21
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

EPHA1_MOUSE
θ value	0.125558 (rank : 41)	NC score	0.089769 (rank : 65)
Query Neighborhood Hits	292	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA5_HUMAN
θ value	0.125558 (rank : 42)	NC score	0.093223 (rank : 58)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB4_HUMAN
θ value	0.125558 (rank : 43)	NC score	0.088473 (rank : 69)
Query Neighborhood Hits	292	Target Neighborhood Hits	1056	Shared Neighborhood Hits	56
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

OGFR_HUMAN
θ value	0.125558 (rank : 44)	NC score	0.075446 (rank : 104)
Query Neighborhood Hits	292	Target Neighborhood Hits	1582	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

VAV_MOUSE
θ value	0.125558 (rank : 45)	NC score	0.125690 (rank : 25)
Query Neighborhood Hits	292	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ADA12_MOUSE
θ value	0.163984 (rank : 46)	NC score	0.018575 (rank : 363)
Query Neighborhood Hits	292	Target Neighborhood Hits	474	Shared Neighborhood Hits	49
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ARHG6_HUMAN
θ value	0.163984 (rank : 47)	NC score	0.146084 (rank : 17)
Query Neighborhood Hits	292	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CEND1_HUMAN
θ value	0.163984 (rank : 48)	NC score	0.077798 (rank : 98)
Query Neighborhood Hits	292	Target Neighborhood Hits	284	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CFAH_MOUSE
θ value	0.163984 (rank : 49)	NC score	0.020561 (rank : 359)
Query Neighborhood Hits	292	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P06909	Gene names	Cfh, Hf1
Domain Architecture
Description	Complement factor H precursor (Protein beta-1-H).

EPHB3_HUMAN
θ value	0.163984 (rank : 50)	NC score	0.091124 (rank : 63)
Query Neighborhood Hits	292	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

PHC2_HUMAN
θ value	0.163984 (rank : 51)	NC score	0.053612 (rank : 224)
Query Neighborhood Hits	292	Target Neighborhood Hits	388	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

ENAH_MOUSE
θ value	0.21417 (rank : 52)	NC score	0.059149 (rank : 167)
Query Neighborhood Hits	292	Target Neighborhood Hits	919	Shared Neighborhood Hits	80
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GRAP_MOUSE
θ value	0.21417 (rank : 53)	NC score	0.135421 (rank : 22)
Query Neighborhood Hits	292	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

M3K9_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.067693 (rank : 121)
Query Neighborhood Hits	292	Target Neighborhood Hits	1123	Shared Neighborhood Hits	103
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CYLD_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.038179 (rank : 291)
Query Neighborhood Hits	292	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

EPHA1_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.087719 (rank : 77)
Query Neighborhood Hits	292	Target Neighborhood Hits	997	Shared Neighborhood Hits	57
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

K1802_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.049602 (rank : 262)
Query Neighborhood Hits	292	Target Neighborhood Hits	1596	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LIPA4_HUMAN
θ value	0.279714 (rank : 58)	NC score	0.026330 (rank : 327)
Query Neighborhood Hits	292	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

NACAM_MOUSE
θ value	0.279714 (rank : 59)	NC score	0.077040 (rank : 100)
Query Neighborhood Hits	292	Target Neighborhood Hits	1866	Shared Neighborhood Hits	140
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

STABP_MOUSE
θ value	0.279714 (rank : 60)	NC score	0.033760 (rank : 303)
Query Neighborhood Hits	292	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

TM108_MOUSE
θ value	0.279714 (rank : 61)	NC score	0.054941 (rank : 208)
Query Neighborhood Hits	292	Target Neighborhood Hits	336	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

ARHG7_MOUSE
θ value	0.365318 (rank : 62)	NC score	0.140090 (rank : 20)
Query Neighborhood Hits	292	Target Neighborhood Hits	396	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CND2_HUMAN
θ value	0.365318 (rank : 63)	NC score	0.039680 (rank : 286)
Query Neighborhood Hits	292	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q15003, Q8TB87	Gene names	NCAPH, BRRN, BRRN1, CAPH, KIAA0074
Domain Architecture
Description	Condensin complex subunit 2 (Non-SMC condensin I complex subunit H) (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (XCAP-H homolog).

HME1_MOUSE
θ value	0.365318 (rank : 64)	NC score	0.017508 (rank : 366)
Query Neighborhood Hits	292	Target Neighborhood Hits	397	Shared Neighborhood Hits	23
SwissProt Accessions	P09065	Gene names	En1, En-1
Domain Architecture
Description	Homeobox protein engrailed-1 (Mo-En-1).

ITSN1_MOUSE
θ value	0.365318 (rank : 65)	NC score	0.093069 (rank : 59)
Query Neighborhood Hits	292	Target Neighborhood Hits	1669	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
θ value	0.365318 (rank : 66)	NC score	0.087160 (rank : 80)
Query Neighborhood Hits	292	Target Neighborhood Hits	1371	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MAP1B_HUMAN
θ value	0.365318 (rank : 67)	NC score	0.056880 (rank : 186)
Query Neighborhood Hits	292	Target Neighborhood Hits	903	Shared Neighborhood Hits	43
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

ZN516_MOUSE
θ value	0.365318 (rank : 68)	NC score	0.010431 (rank : 401)
Query Neighborhood Hits	292	Target Neighborhood Hits	1197	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

JIP3_HUMAN
θ value	0.47712 (rank : 69)	NC score	0.034099 (rank : 302)
Query Neighborhood Hits	292	Target Neighborhood Hits	1039	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

PXK_MOUSE
θ value	0.47712 (rank : 70)	NC score	0.050685 (rank : 254)
Query Neighborhood Hits	292	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SON_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.067288 (rank : 122)
Query Neighborhood Hits	292	Target Neighborhood Hits	1568	Shared Neighborhood Hits	135
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CD2AP_MOUSE
θ value	0.62314 (rank : 72)	NC score	0.171493 (rank : 14)
Query Neighborhood Hits	292	Target Neighborhood Hits	336	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CHRD_MOUSE
θ value	0.62314 (rank : 73)	NC score	0.028101 (rank : 318)
Query Neighborhood Hits	292	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

CLCN2_MOUSE
θ value	0.62314 (rank : 74)	NC score	0.022667 (rank : 345)
Query Neighborhood Hits	292	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

EPHA8_HUMAN
θ value	0.62314 (rank : 75)	NC score	0.087186 (rank : 79)
Query Neighborhood Hits	292	Target Neighborhood Hits	956	Shared Neighborhood Hits	52
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	0.62314 (rank : 76)	NC score	0.088368 (rank : 71)
Query Neighborhood Hits	292	Target Neighborhood Hits	969	Shared Neighborhood Hits	54
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FMN1A_MOUSE
θ value	0.62314 (rank : 77)	NC score	0.053699 (rank : 223)
Query Neighborhood Hits	292	Target Neighborhood Hits	423	Shared Neighborhood Hits	54
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	0.62314 (rank : 78)	NC score	0.054685 (rank : 209)
Query Neighborhood Hits	292	Target Neighborhood Hits	447	Shared Neighborhood Hits	58
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

IWS1_HUMAN
θ value	0.62314 (rank : 79)	NC score	0.047515 (rank : 268)
Query Neighborhood Hits	292	Target Neighborhood Hits	1241	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JHD2A_MOUSE
θ value	0.62314 (rank : 80)	NC score	0.037295 (rank : 294)
Query Neighborhood Hits	292	Target Neighborhood Hits	123	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

MYO1F_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.068980 (rank : 117)
Query Neighborhood Hits	292	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

STAC_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.119669 (rank : 30)
Query Neighborhood Hits	292	Target Neighborhood Hits	276	Shared Neighborhood Hits	66
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV3_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.109538 (rank : 36)
Query Neighborhood Hits	292	Target Neighborhood Hits	398	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ZN385_HUMAN
θ value	0.62314 (rank : 84)	NC score	0.047788 (rank : 267)
Query Neighborhood Hits	292	Target Neighborhood Hits	614	Shared Neighborhood Hits	63
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CASG_MOUSE
θ value	0.813845 (rank : 85)	NC score	0.079667 (rank : 91)
Query Neighborhood Hits	292	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02862	Gene names	Csng
Domain Architecture	No domain graphic available
Description	Gamma-casein precursor (PP22).

CEND3_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.064646 (rank : 134)
Query Neighborhood Hits	292	Target Neighborhood Hits	275	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

EPHB2_HUMAN
θ value	0.813845 (rank : 87)	NC score	0.088334 (rank : 73)
Query Neighborhood Hits	292	Target Neighborhood Hits	983	Shared Neighborhood Hits	54
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	0.813845 (rank : 88)	NC score	0.088004 (rank : 76)
Query Neighborhood Hits	292	Target Neighborhood Hits	982	Shared Neighborhood Hits	54
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

FGD1_MOUSE
θ value	0.813845 (rank : 89)	NC score	0.040912 (rank : 282)
Query Neighborhood Hits	292	Target Neighborhood Hits	387	Shared Neighborhood Hits	65
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GFAP_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.022500 (rank : 347)
Query Neighborhood Hits	292	Target Neighborhood Hits	723	Shared Neighborhood Hits	21
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

IASPP_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.071007 (rank : 106)
Query Neighborhood Hits	292	Target Neighborhood Hits	1024	Shared Neighborhood Hits	125
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITSN2_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.087418 (rank : 78)
Query Neighborhood Hits	292	Target Neighborhood Hits	1173	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LCP2_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.062100 (rank : 155)
Query Neighborhood Hits	292	Target Neighborhood Hits	531	Shared Neighborhood Hits	65
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MAST1_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.023531 (rank : 341)
Query Neighborhood Hits	292	Target Neighborhood Hits	1146	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NCK2_HUMAN
θ value	0.813845 (rank : 95)	NC score	0.125258 (rank : 27)
Query Neighborhood Hits	292	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOA6_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.063818 (rank : 140)
Query Neighborhood Hits	292	Target Neighborhood Hits	1202	Shared Neighborhood Hits	116
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

WASIP_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.076329 (rank : 101)
Query Neighborhood Hits	292	Target Neighborhood Hits	458	Shared Neighborhood Hits	65
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

AL2S4_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.057771 (rank : 179)
Query Neighborhood Hits	292	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ARHG6_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.137954 (rank : 21)
Query Neighborhood Hits	292	Target Neighborhood Hits	394	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CABL2_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.030892 (rank : 313)
Query Neighborhood Hits	292	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CD2L5_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.029071 (rank : 316)
Query Neighborhood Hits	292	Target Neighborhood Hits	987	Shared Neighborhood Hits	54
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

FMNL_HUMAN
θ value	1.06291 (rank : 102)	NC score	0.051416 (rank : 246)
Query Neighborhood Hits	292	Target Neighborhood Hits	529	Shared Neighborhood Hits	55
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GFAP_MOUSE
θ value	1.06291 (rank : 103)	NC score	0.018940 (rank : 361)
Query Neighborhood Hits	292	Target Neighborhood Hits	725	Shared Neighborhood Hits	19
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GRAP2_MOUSE
θ value	1.06291 (rank : 104)	NC score	0.113131 (rank : 33)
Query Neighborhood Hits	292	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MNT_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.048117 (rank : 266)
Query Neighborhood Hits	292	Target Neighborhood Hits	432	Shared Neighborhood Hits	51
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MTSS1_MOUSE
θ value	1.06291 (rank : 106)	NC score	0.045017 (rank : 271)
Query Neighborhood Hits	292	Target Neighborhood Hits	592	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

VAV3_MOUSE
θ value	1.06291 (rank : 107)	NC score	0.107042 (rank : 40)
Query Neighborhood Hits	292	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BCL9_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.056712 (rank : 188)
Query Neighborhood Hits	292	Target Neighborhood Hits	1008	Shared Neighborhood Hits	109
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CEND1_MOUSE
θ value	1.38821 (rank : 109)	NC score	0.062144 (rank : 153)
Query Neighborhood Hits	292	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CK5P2_HUMAN
θ value	1.38821 (rank : 110)	NC score	0.017613 (rank : 365)
Query Neighborhood Hits	292	Target Neighborhood Hits	1433	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

EPHAA_HUMAN
θ value	1.38821 (rank : 111)	NC score	0.094004 (rank : 56)
Query Neighborhood Hits	292	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB3_MOUSE
θ value	1.38821 (rank : 112)	NC score	0.088858 (rank : 68)
Query Neighborhood Hits	292	Target Neighborhood Hits	996	Shared Neighborhood Hits	55
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

IWS1_MOUSE
θ value	1.38821 (rank : 113)	NC score	0.051794 (rank : 243)
Query Neighborhood Hits	292	Target Neighborhood Hits	1258	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JPH1_MOUSE
θ value	1.38821 (rank : 114)	NC score	0.027854 (rank : 319)
Query Neighborhood Hits	292	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

KGP2_HUMAN
θ value	1.38821 (rank : 115)	NC score	0.022370 (rank : 349)
Query Neighborhood Hits	292	Target Neighborhood Hits	1023	Shared Neighborhood Hits	45
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MAST1_MOUSE
θ value	1.38821 (rank : 116)	NC score	0.022463 (rank : 348)
Query Neighborhood Hits	292	Target Neighborhood Hits	1123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PRR13_HUMAN
θ value	1.38821 (rank : 117)	NC score	0.080901 (rank : 88)
Query Neighborhood Hits	292	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

RANB9_HUMAN
θ value	1.38821 (rank : 118)	NC score	0.039525 (rank : 287)
Query Neighborhood Hits	292	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

AFF2_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.032046 (rank : 308)
Query Neighborhood Hits	292	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

BAG3_MOUSE
θ value	1.81305 (rank : 120)	NC score	0.044644 (rank : 272)
Query Neighborhood Hits	292	Target Neighborhood Hits	513	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BMS1_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.035336 (rank : 300)
Query Neighborhood Hits	292	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

CBPZ_MOUSE
θ value	1.81305 (rank : 122)	NC score	0.010549 (rank : 400)
Query Neighborhood Hits	292	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R4V4	Gene names	Cpz
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

CECR2_HUMAN
θ value	1.81305 (rank : 123)	NC score	0.043029 (rank : 276)
Query Neighborhood Hits	292	Target Neighborhood Hits	543	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEND3_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.062469 (rank : 150)
Query Neighborhood Hits	292	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CSKP_HUMAN
θ value	1.81305 (rank : 125)	NC score	0.031594 (rank : 311)
Query Neighborhood Hits	292	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	1.81305 (rank : 126)	NC score	0.031289 (rank : 312)
Query Neighborhood Hits	292	Target Neighborhood Hits	1027	Shared Neighborhood Hits	81
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DLGP4_HUMAN
θ value	1.81305 (rank : 127)	NC score	0.023406 (rank : 342)
Query Neighborhood Hits	292	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

EVC_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.032050 (rank : 307)
Query Neighborhood Hits	292	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	P57679	Gene names	EVC
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein (DWF-1).

FOG1_MOUSE
θ value	1.81305 (rank : 129)	NC score	0.014607 (rank : 381)
Query Neighborhood Hits	292	Target Neighborhood Hits	1237	Shared Neighborhood Hits	71
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HCN2_HUMAN
θ value	1.81305 (rank : 130)	NC score	0.024239 (rank : 335)
Query Neighborhood Hits	292	Target Neighborhood Hits	369	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

K0179_HUMAN
θ value	1.81305 (rank : 131)	NC score	0.036528 (rank : 297)
Query Neighborhood Hits	292	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

P85B_HUMAN
θ value	1.81305 (rank : 132)	NC score	0.038878 (rank : 289)
Query Neighborhood Hits	292	Target Neighborhood Hits	543	Shared Neighborhood Hits	40
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PER1_HUMAN
θ value	1.81305 (rank : 133)	NC score	0.024919 (rank : 332)
Query Neighborhood Hits	292	Target Neighborhood Hits	215	Shared Neighborhood Hits	35
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PXK_HUMAN
θ value	1.81305 (rank : 134)	NC score	0.038609 (rank : 290)
Query Neighborhood Hits	292	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SC24B_HUMAN
θ value	1.81305 (rank : 135)	NC score	0.026104 (rank : 328)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	20
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

SOX13_HUMAN
θ value	1.81305 (rank : 136)	NC score	0.027336 (rank : 320)
Query Neighborhood Hits	292	Target Neighborhood Hits	464	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

STAC_MOUSE
θ value	1.81305 (rank : 137)	NC score	0.117424 (rank : 31)
Query Neighborhood Hits	292	Target Neighborhood Hits	268	Shared Neighborhood Hits	66
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TMAP1_HUMAN
θ value	1.81305 (rank : 138)	NC score	0.066896 (rank : 125)
Query Neighborhood Hits	292	Target Neighborhood Hits	140	Shared Neighborhood Hits	25
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

WASP_MOUSE
θ value	1.81305 (rank : 139)	NC score	0.052939 (rank : 230)
Query Neighborhood Hits	292	Target Neighborhood Hits	223	Shared Neighborhood Hits	47
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

AP2A_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.021758 (rank : 354)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

AP2A_MOUSE
θ value	2.36792 (rank : 141)	NC score	0.021787 (rank : 353)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

DDX50_MOUSE
θ value	2.36792 (rank : 142)	NC score	0.010979 (rank : 397)
Query Neighborhood Hits	292	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

GRAP2_HUMAN
θ value	2.36792 (rank : 143)	NC score	0.105623 (rank : 41)
Query Neighborhood Hits	292	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

HME1_HUMAN
θ value	2.36792 (rank : 144)	NC score	0.013985 (rank : 385)
Query Neighborhood Hits	292	Target Neighborhood Hits	384	Shared Neighborhood Hits	20
SwissProt Accessions	Q05925	Gene names	EN1
Domain Architecture
Description	Homeobox protein engrailed-1 (Hu-En-1).

IQEC3_MOUSE
θ value	2.36792 (rank : 145)	NC score	0.022155 (rank : 352)
Query Neighborhood Hits	292	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

JHD2C_HUMAN
θ value	2.36792 (rank : 146)	NC score	0.024415 (rank : 334)
Query Neighborhood Hits	292	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

MAP1A_HUMAN
θ value	2.36792 (rank : 147)	NC score	0.042979 (rank : 277)
Query Neighborhood Hits	292	Target Neighborhood Hits	1626	Shared Neighborhood Hits	96
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MAVS_HUMAN
θ value	2.36792 (rank : 148)	NC score	0.055277 (rank : 204)
Query Neighborhood Hits	292	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MLL2_HUMAN
θ value	2.36792 (rank : 149)	NC score	0.041884 (rank : 279)
Query Neighborhood Hits	292	Target Neighborhood Hits	1788	Shared Neighborhood Hits	113
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PRC1_MOUSE
θ value	2.36792 (rank : 150)	NC score	0.030695 (rank : 314)
Query Neighborhood Hits	292	Target Neighborhood Hits	382	Shared Neighborhood Hits	17
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

RASF8_HUMAN
θ value	2.36792 (rank : 151)	NC score	0.017458 (rank : 367)
Query Neighborhood Hits	292	Target Neighborhood Hits	469	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

SALL3_HUMAN
θ value	2.36792 (rank : 152)	NC score	0.007841 (rank : 407)
Query Neighborhood Hits	292	Target Neighborhood Hits	1066	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SH3G3_MOUSE
θ value	2.36792 (rank : 153)	NC score	0.107502 (rank : 39)
Query Neighborhood Hits	292	Target Neighborhood Hits	236	Shared Neighborhood Hits	59
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SMR1_MOUSE
θ value	2.36792 (rank : 154)	NC score	0.059223 (rank : 166)
Query Neighborhood Hits	292	Target Neighborhood Hits	103	Shared Neighborhood Hits	25
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

TBCD8_MOUSE
θ value	2.36792 (rank : 155)	NC score	0.016223 (rank : 376)
Query Neighborhood Hits	292	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1A9	Gene names	Tbc1d8, Hblp1, Vrp
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (BUB2-like protein 1).

VAV2_MOUSE
θ value	2.36792 (rank : 156)	NC score	0.098475 (rank : 46)
Query Neighborhood Hits	292	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ZDHC8_MOUSE
θ value	2.36792 (rank : 157)	NC score	0.015412 (rank : 379)
Query Neighborhood Hits	292	Target Neighborhood Hits	243	Shared Neighborhood Hits	23
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

BAT2_HUMAN
θ value	3.0926 (rank : 158)	NC score	0.054456 (rank : 212)
Query Neighborhood Hits	292	Target Neighborhood Hits	931	Shared Neighborhood Hits	101
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BSN_MOUSE
θ value	3.0926 (rank : 159)	NC score	0.058435 (rank : 173)
Query Neighborhood Hits	292	Target Neighborhood Hits	2057	Shared Neighborhood Hits	136
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CD248_HUMAN
θ value	3.0926 (rank : 160)	NC score	0.023533 (rank : 340)
Query Neighborhood Hits	292	Target Neighborhood Hits	679	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

DPOD3_MOUSE
θ value	3.0926 (rank : 161)	NC score	0.031998 (rank : 310)
Query Neighborhood Hits	292	Target Neighborhood Hits	118	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EQ28	Gene names	Pold3
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

EPHA2_MOUSE
θ value	3.0926 (rank : 162)	NC score	0.088126 (rank : 75)
Query Neighborhood Hits	292	Target Neighborhood Hits	1020	Shared Neighborhood Hits	58
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FUBP1_HUMAN
θ value	3.0926 (rank : 163)	NC score	0.023631 (rank : 337)
Query Neighborhood Hits	292	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

FUBP1_MOUSE
θ value	3.0926 (rank : 164)	NC score	0.023345 (rank : 343)
Query Neighborhood Hits	292	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

GGN_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.052679 (rank : 236)
Query Neighborhood Hits	292	Target Neighborhood Hits	311	Shared Neighborhood Hits	52
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRIN1_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.040404 (rank : 284)
Query Neighborhood Hits	292	Target Neighborhood Hits	681	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HCLS1_HUMAN
θ value	3.0926 (rank : 167)	NC score	0.088449 (rank : 70)
Query Neighborhood Hits	292	Target Neighborhood Hits	358	Shared Neighborhood Hits	81
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

KGP2_MOUSE
θ value	3.0926 (rank : 168)	NC score	0.021458 (rank : 356)
Query Neighborhood Hits	292	Target Neighborhood Hits	1029	Shared Neighborhood Hits	44
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MDC1_MOUSE
θ value	3.0926 (rank : 169)	NC score	0.048611 (rank : 264)
Query Neighborhood Hits	292	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MYRIP_HUMAN
θ value	3.0926 (rank : 170)	NC score	0.018768 (rank : 362)
Query Neighborhood Hits	292	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

SRRM2_MOUSE
θ value	3.0926 (rank : 171)	NC score	0.063727 (rank : 142)
Query Neighborhood Hits	292	Target Neighborhood Hits	1470	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

VAV2_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.098460 (rank : 47)
Query Neighborhood Hits	292	Target Neighborhood Hits	453	Shared Neighborhood Hits	60
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VSX1_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.006888 (rank : 409)
Query Neighborhood Hits	292	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZR4, Q5TF40, Q5TF41, Q9HCU3, Q9NU27	Gene names	VSX1, RINX
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

WBP11_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.065963 (rank : 128)
Query Neighborhood Hits	292	Target Neighborhood Hits	354	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.065955 (rank : 129)
Query Neighborhood Hits	292	Target Neighborhood Hits	362	Shared Neighborhood Hits	58
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

CEL_HUMAN
θ value	4.03905 (rank : 176)	NC score	0.037318 (rank : 293)
Query Neighborhood Hits	292	Target Neighborhood Hits	896	Shared Neighborhood Hits	89
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

MARK3_MOUSE
θ value	4.03905 (rank : 177)	NC score	0.025799 (rank : 329)
Query Neighborhood Hits	292	Target Neighborhood Hits	919	Shared Neighborhood Hits	47
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MCSP_MOUSE
θ value	4.03905 (rank : 178)	NC score	0.025724 (rank : 330)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

NCF1_MOUSE
θ value	4.03905 (rank : 179)	NC score	0.095475 (rank : 53)
Query Neighborhood Hits	292	Target Neighborhood Hits	198	Shared Neighborhood Hits	54
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NUMBL_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.036339 (rank : 298)
Query Neighborhood Hits	292	Target Neighborhood Hits	147	Shared Neighborhood Hits	27
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

PDZD2_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.032012 (rank : 309)
Query Neighborhood Hits	292	Target Neighborhood Hits	772	Shared Neighborhood Hits	67
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PELP1_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.042617 (rank : 278)
Query Neighborhood Hits	292	Target Neighborhood Hits	596	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PHLB1_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.026969 (rank : 323)
Query Neighborhood Hits	292	Target Neighborhood Hits	1038	Shared Neighborhood Hits	74
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PSL1_HUMAN
θ value	4.03905 (rank : 184)	NC score	0.041507 (rank : 281)
Query Neighborhood Hits	292	Target Neighborhood Hits	650	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RAI1_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.032613 (rank : 305)
Query Neighborhood Hits	292	Target Neighborhood Hits	360	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RGS3_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.040338 (rank : 285)
Query Neighborhood Hits	292	Target Neighborhood Hits	1375	Shared Neighborhood Hits	125
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RP1L1_HUMAN
θ value	4.03905 (rank : 187)	NC score	0.032939 (rank : 304)
Query Neighborhood Hits	292	Target Neighborhood Hits	1072	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SF3A2_MOUSE
θ value	4.03905 (rank : 188)	NC score	0.052744 (rank : 233)
Query Neighborhood Hits	292	Target Neighborhood Hits	247	Shared Neighborhood Hits	39
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

STK10_HUMAN
θ value	4.03905 (rank : 189)	NC score	0.026952 (rank : 324)
Query Neighborhood Hits	292	Target Neighborhood Hits	1921	Shared Neighborhood Hits	80
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TCGAP_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.066123 (rank : 127)
Query Neighborhood Hits	292	Target Neighborhood Hits	872	Shared Neighborhood Hits	137
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TLE1_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.016838 (rank : 371)
Query Neighborhood Hits	292	Target Neighborhood Hits	485	Shared Neighborhood Hits	41
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

AATK_HUMAN
θ value	5.27518 (rank : 192)	NC score	0.049948 (rank : 261)
Query Neighborhood Hits	292	Target Neighborhood Hits	1243	Shared Neighborhood Hits	97
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ABI2_MOUSE
θ value	5.27518 (rank : 193)	NC score	0.096739 (rank : 50)
Query Neighborhood Hits	292	Target Neighborhood Hits	266	Shared Neighborhood Hits	65
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CO8A1_HUMAN
θ value	5.27518 (rank : 194)	NC score	0.016303 (rank : 374)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

ESX1L_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.012664 (rank : 389)
Query Neighborhood Hits	292	Target Neighborhood Hits	498	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

GSCR1_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.069433 (rank : 114)
Query Neighborhood Hits	292	Target Neighborhood Hits	674	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

IKAR_HUMAN
θ value	5.27518 (rank : 197)	NC score	-0.001152 (rank : 418)
Query Neighborhood Hits	292	Target Neighborhood Hits	726	Shared Neighborhood Hits	12
SwissProt Accessions	Q13422, O00598, Q8WVA3	Gene names	IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

JADE2_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.030615 (rank : 315)
Query Neighborhood Hits	292	Target Neighborhood Hits	560	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

MAST2_MOUSE
θ value	5.27518 (rank : 199)	NC score	0.021040 (rank : 358)
Query Neighborhood Hits	292	Target Neighborhood Hits	1110	Shared Neighborhood Hits	64
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NCOA6_MOUSE
θ value	5.27518 (rank : 200)	NC score	0.050978 (rank : 251)
Query Neighborhood Hits	292	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NFIA_MOUSE
θ value	5.27518 (rank : 201)	NC score	0.016891 (rank : 370)
Query Neighborhood Hits	292	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q02780, P70250, P70251, Q3UUZ2, Q61960, Q8VBT5, Q9R1G5	Gene names	Nfia
Domain Architecture
Description	Nuclear factor 1 A-type (Nuclear factor 1/A) (NF1-A) (NFI-A) (NF-I/A) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

NOTC3_MOUSE
θ value	5.27518 (rank : 202)	NC score	0.013762 (rank : 386)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	49
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

RREB1_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.005935 (rank : 412)
Query Neighborhood Hits	292	Target Neighborhood Hits	879	Shared Neighborhood Hits	37
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

SF3A2_HUMAN
θ value	5.27518 (rank : 204)	NC score	0.055034 (rank : 205)
Query Neighborhood Hits	292	Target Neighborhood Hits	263	Shared Neighborhood Hits	44
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SFTA1_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.010721 (rank : 398)
Query Neighborhood Hits	292	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWL2, P07714, Q5RIR5, Q5RIR7, Q6PIT0, Q8TC19	Gene names	SFTPA1, PSAP, SFTP1, SFTPA
Domain Architecture	No domain graphic available
Description	Pulmonary surfactant-associated protein A1 precursor (SP-A1) (SP-A) (PSP-A) (PSPA) (Alveolar proteinosis protein) (35 kDa pulmonary surfactant-associated protein).

SHAN2_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.048404 (rank : 265)
Query Neighborhood Hits	292	Target Neighborhood Hits	346	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	5.27518 (rank : 207)	NC score	0.086681 (rank : 82)
Query Neighborhood Hits	292	Target Neighborhood Hits	446	Shared Neighborhood Hits	104
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SOX13_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.023558 (rank : 339)
Query Neighborhood Hits	292	Target Neighborhood Hits	495	Shared Neighborhood Hits	54
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SRBS1_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.114180 (rank : 32)
Query Neighborhood Hits	292	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	5.27518 (rank : 210)	NC score	0.111765 (rank : 34)
Query Neighborhood Hits	292	Target Neighborhood Hits	409	Shared Neighborhood Hits	73
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SSRP1_HUMAN
θ value	5.27518 (rank : 211)	NC score	0.021567 (rank : 355)
Query Neighborhood Hits	292	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	Q08945, Q5BJG8	Gene names	SSRP1, FACT80
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin- specific transcription elongation factor 80 kDa subunit) (Structure- specific recognition protein 1) (hSSRP1) (Recombination signal sequence recognition protein 1) (T160).

WASF2_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.043596 (rank : 275)
Query Neighborhood Hits	292	Target Neighborhood Hits	315	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ZN358_HUMAN
θ value	5.27518 (rank : 213)	NC score	-0.001000 (rank : 417)
Query Neighborhood Hits	292	Target Neighborhood Hits	840	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

3BP1_HUMAN
θ value	6.88961 (rank : 214)	NC score	0.035978 (rank : 299)
Query Neighborhood Hits	292	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABI2_HUMAN
θ value	6.88961 (rank : 215)	NC score	0.101165 (rank : 44)
Query Neighborhood Hits	292	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ANDR_MOUSE
θ value	6.88961 (rank : 216)	NC score	0.004868 (rank : 414)
Query Neighborhood Hits	292	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ANTR1_MOUSE
θ value	6.88961 (rank : 217)	NC score	0.028501 (rank : 317)
Query Neighborhood Hits	292	Target Neighborhood Hits	143	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

CO3A1_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.021440 (rank : 357)
Query Neighborhood Hits	292	Target Neighborhood Hits	466	Shared Neighborhood Hits	51
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO9A1_MOUSE
θ value	6.88961 (rank : 219)	NC score	0.013478 (rank : 387)
Query Neighborhood Hits	292	Target Neighborhood Hits	477	Shared Neighborhood Hits	51
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

DMRTD_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.016652 (rank : 372)
Query Neighborhood Hits	292	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

DNL1_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.022744 (rank : 344)
Query Neighborhood Hits	292	Target Neighborhood Hits	110	Shared Neighborhood Hits	16
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

EHMT1_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.026840 (rank : 326)
Query Neighborhood Hits	292	Target Neighborhood Hits	417	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

EPHA2_HUMAN
θ value	6.88961 (rank : 223)	NC score	0.086372 (rank : 83)
Query Neighborhood Hits	292	Target Neighborhood Hits	1021	Shared Neighborhood Hits	57
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

IF35_MOUSE
θ value	6.88961 (rank : 224)	NC score	0.037263 (rank : 295)
Query Neighborhood Hits	292	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IQGA2_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.015535 (rank : 377)
Query Neighborhood Hits	292	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

K0310_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.034741 (rank : 301)
Query Neighborhood Hits	292	Target Neighborhood Hits	420	Shared Neighborhood Hits	50
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MYCD_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.011431 (rank : 394)
Query Neighborhood Hits	292	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

MYO1F_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.054303 (rank : 214)
Query Neighborhood Hits	292	Target Neighborhood Hits	262	Shared Neighborhood Hits	59
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NEMO_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.012193 (rank : 392)
Query Neighborhood Hits	292	Target Neighborhood Hits	820	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NFIA_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.016228 (rank : 375)
Query Neighborhood Hits	292	Target Neighborhood Hits	65	Shared Neighborhood Hits	15
SwissProt Accessions	Q12857, Q9H3X9, Q9P2A9	Gene names	NFIA, KIAA1439
Domain Architecture
Description	Nuclear factor 1 A-type (Nuclear factor 1/A) (NF1-A) (NFI-A) (NF-I/A) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

NPHP1_MOUSE
θ value	6.88961 (rank : 231)	NC score	0.084616 (rank : 85)
Query Neighborhood Hits	292	Target Neighborhood Hits	267	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NUFP1_MOUSE
θ value	6.88961 (rank : 232)	NC score	0.014535 (rank : 383)
Query Neighborhood Hits	292	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXX8, Q9CV69	Gene names	Nufip1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

OCLN_MOUSE
θ value	6.88961 (rank : 233)	NC score	0.012327 (rank : 390)
Query Neighborhood Hits	292	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q61146, Q544A7	Gene names	Ocln, Ocl
Domain Architecture
Description	Occludin.

OSTF1_MOUSE
θ value	6.88961 (rank : 234)	NC score	0.089127 (rank : 67)
Query Neighborhood Hits	292	Target Neighborhood Hits	467	Shared Neighborhood Hits	68
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PHC1_MOUSE
θ value	6.88961 (rank : 235)	NC score	0.027114 (rank : 322)
Query Neighborhood Hits	292	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

PHLPP_HUMAN
θ value	6.88961 (rank : 236)	NC score	0.011343 (rank : 395)
Query Neighborhood Hits	292	Target Neighborhood Hits	604	Shared Neighborhood Hits	42
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PLXB1_HUMAN
θ value	6.88961 (rank : 237)	NC score	0.012786 (rank : 388)
Query Neighborhood Hits	292	Target Neighborhood Hits	360	Shared Neighborhood Hits	54
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

PRGR_MOUSE
θ value	6.88961 (rank : 238)	NC score	0.011254 (rank : 396)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

RAI14_HUMAN
θ value	6.88961 (rank : 239)	NC score	0.023618 (rank : 338)
Query Neighborhood Hits	292	Target Neighborhood Hits	1367	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SIN3A_MOUSE
θ value	6.88961 (rank : 240)	NC score	0.018153 (rank : 364)
Query Neighborhood Hits	292	Target Neighborhood Hits	169	Shared Neighborhood Hits	30
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SPR1A_MOUSE
θ value	6.88961 (rank : 241)	NC score	0.038950 (rank : 288)
Query Neighborhood Hits	292	Target Neighborhood Hits	343	Shared Neighborhood Hits	61
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR2D_MOUSE
θ value	6.88961 (rank : 242)	NC score	0.027286 (rank : 321)
Query Neighborhood Hits	292	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

TB182_HUMAN
θ value	6.88961 (rank : 243)	NC score	0.037023 (rank : 296)
Query Neighborhood Hits	292	Target Neighborhood Hits	414	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TLE4_HUMAN
θ value	6.88961 (rank : 244)	NC score	0.017166 (rank : 368)
Query Neighborhood Hits	292	Target Neighborhood Hits	477	Shared Neighborhood Hits	49
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

USH2A_MOUSE
θ value	6.88961 (rank : 245)	NC score	0.022268 (rank : 351)
Query Neighborhood Hits	292	Target Neighborhood Hits	626	Shared Neighborhood Hits	33
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VINEX_MOUSE
θ value	6.88961 (rank : 246)	NC score	0.104324 (rank : 42)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WASL_MOUSE
θ value	6.88961 (rank : 247)	NC score	0.050347 (rank : 259)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ZIC5_HUMAN
θ value	6.88961 (rank : 248)	NC score	-0.001445 (rank : 419)
Query Neighborhood Hits	292	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

AIRE_MOUSE
θ value	8.99809 (rank : 249)	NC score	0.012022 (rank : 393)
Query Neighborhood Hits	292	Target Neighborhood Hits	196	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

ANK2_HUMAN
θ value	8.99809 (rank : 250)	NC score	0.044070 (rank : 274)
Query Neighborhood Hits	292	Target Neighborhood Hits	1615	Shared Neighborhood Hits	107
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANR25_HUMAN
θ value	8.99809 (rank : 251)	NC score	0.024647 (rank : 333)
Query Neighborhood Hits	292	Target Neighborhood Hits	350	Shared Neighborhood Hits	23
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

ATS20_MOUSE
θ value	8.99809 (rank : 252)	NC score	0.002713 (rank : 416)
Query Neighborhood Hits	292	Target Neighborhood Hits	225	Shared Neighborhood Hits	6
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

BAG4_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.016957 (rank : 369)
Query Neighborhood Hits	292	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	O95429, O95818	Gene names	BAG4, SODD
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

BSN_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.044160 (rank : 273)
Query Neighborhood Hits	292	Target Neighborhood Hits	1537	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CAC2D_MOUSE
θ value	8.99809 (rank : 255)	NC score	0.022273 (rank : 350)
Query Neighborhood Hits	292	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CO5A2_HUMAN
θ value	8.99809 (rank : 256)	NC score	0.019893 (rank : 360)
Query Neighborhood Hits	292	Target Neighborhood Hits	760	Shared Neighborhood Hits	69
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

DNM3A_MOUSE
θ value	8.99809 (rank : 257)	NC score	0.008666 (rank : 405)
Query Neighborhood Hits	292	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

EPHA5_MOUSE
θ value	8.99809 (rank : 258)	NC score	0.078397 (rank : 95)
Query Neighborhood Hits	292	Target Neighborhood Hits	950	Shared Neighborhood Hits	54
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FAIM2_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.008899 (rank : 404)
Query Neighborhood Hits	292	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K097, Q3TY22, Q8K1F6, Q9D6K4	Gene names	Faim2, Kiaa0950, Lfg
Domain Architecture
Description	Fas apoptotic inhibitory molecule 2 (Lifeguard protein).

HLX1_HUMAN
θ value	8.99809 (rank : 260)	NC score	0.002991 (rank : 415)
Query Neighborhood Hits	292	Target Neighborhood Hits	370	Shared Neighborhood Hits	9
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

IRF6_HUMAN
θ value	8.99809 (rank : 261)	NC score	0.005302 (rank : 413)
Query Neighborhood Hits	292	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O14896	Gene names	IRF6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

JHD2A_HUMAN
θ value	8.99809 (rank : 262)	NC score	0.032482 (rank : 306)
Query Neighborhood Hits	292	Target Neighborhood Hits	118	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

LCP2_MOUSE
θ value	8.99809 (rank : 263)	NC score	0.054471 (rank : 211)
Query Neighborhood Hits	292	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LRP10_HUMAN
θ value	8.99809 (rank : 264)	NC score	0.006237 (rank : 411)
Query Neighborhood Hits	292	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

MARK3_HUMAN
θ value	8.99809 (rank : 265)	NC score	0.024966 (rank : 331)
Query Neighborhood Hits	292	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MINT_MOUSE
θ value	8.99809 (rank : 266)	NC score	0.048895 (rank : 263)
Query Neighborhood Hits	292	Target Neighborhood Hits	1514	Shared Neighborhood Hits	113
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MYCB2_HUMAN
θ value	8.99809 (rank : 267)	NC score	0.012314 (rank : 391)
Query Neighborhood Hits	292	Target Neighborhood Hits	390	Shared Neighborhood Hits	23
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NAT6_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.014545 (rank : 382)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

NFIC_HUMAN
θ value	8.99809 (rank : 269)	NC score	0.015015 (rank : 380)
Query Neighborhood Hits	292	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P08651, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1	Gene names	NFIC, NFI
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

NOTC3_HUMAN
θ value	8.99809 (rank : 270)	NC score	0.015490 (rank : 378)
Query Neighborhood Hits	292	Target Neighborhood Hits	1062	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NUMBL_HUMAN
θ value	8.99809 (rank : 271)	NC score	0.046145 (rank : 270)
Query Neighborhood Hits	292	Target Neighborhood Hits	394	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

OSTF1_HUMAN
θ value	8.99809 (rank : 272)	NC score	0.088157 (rank : 74)
Query Neighborhood Hits	292	Target Neighborhood Hits	466	Shared Neighborhood Hits	68
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PELP1_MOUSE
θ value	8.99809 (rank : 273)	NC score	0.047253 (rank : 269)
Query Neighborhood Hits	292	Target Neighborhood Hits	709	Shared Neighborhood Hits	78
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PHF12_HUMAN
θ value	8.99809 (rank : 274)	NC score	0.009751 (rank : 402)
Query Neighborhood Hits	292	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PIGQ_HUMAN
θ value	8.99809 (rank : 275)	NC score	0.014073 (rank : 384)
Query Neighborhood Hits	292	Target Neighborhood Hits	84	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BRB3, O14927, Q96G00, Q96S22, Q9UJH4	Gene names	PIGQ, GPI1
Domain Architecture
Description	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) (N-acetylglucosamyl transferase component GPI1).

PRR12_HUMAN
θ value	8.99809 (rank : 276)	NC score	0.078619 (rank : 93)
Query Neighborhood Hits	292	Target Neighborhood Hits	460	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RBM12_MOUSE
θ value	8.99809 (rank : 277)	NC score	0.026947 (rank : 325)
Query Neighborhood Hits	292	Target Neighborhood Hits	313	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

RGS3_MOUSE
θ value	8.99809 (rank : 278)	NC score	0.051259 (rank : 247)
Query Neighborhood Hits	292	Target Neighborhood Hits	1621	Shared Neighborhood Hits	132
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SH3G1_HUMAN
θ value	8.99809 (rank : 279)	NC score	0.080187 (rank : 89)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	8.99809 (rank : 280)	NC score	0.082444 (rank : 87)
Query Neighborhood Hits	292	Target Neighborhood Hits	291	Shared Neighborhood Hits	60
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
θ value	8.99809 (rank : 281)	NC score	0.095640 (rank : 52)
Query Neighborhood Hits	292	Target Neighborhood Hits	319	Shared Neighborhood Hits	60
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SMCA2_HUMAN
θ value	8.99809 (rank : 282)	NC score	0.009656 (rank : 403)
Query Neighborhood Hits	292	Target Neighborhood Hits	503	Shared Neighborhood Hits	49
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SPR2H_MOUSE
θ value	8.99809 (rank : 283)	NC score	0.022584 (rank : 346)
Query Neighborhood Hits	292	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

TLE4_MOUSE
θ value	8.99809 (rank : 284)	NC score	0.016505 (rank : 373)
Query Neighborhood Hits	292	Target Neighborhood Hits	482	Shared Neighborhood Hits	52
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

TRI47_HUMAN
θ value	8.99809 (rank : 285)	NC score	0.007827 (rank : 408)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	11
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	8.99809 (rank : 286)	NC score	0.006789 (rank : 410)
Query Neighborhood Hits	292	Target Neighborhood Hits	295	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRPS1_MOUSE
θ value	8.99809 (rank : 287)	NC score	0.010636 (rank : 399)
Query Neighborhood Hits	292	Target Neighborhood Hits	609	Shared Neighborhood Hits	18
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

VINEX_HUMAN
θ value	8.99809 (rank : 288)	NC score	0.108523 (rank : 38)
Query Neighborhood Hits	292	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

WASF1_HUMAN
θ value	8.99809 (rank : 289)	NC score	0.040437 (rank : 283)
Query Neighborhood Hits	292	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF2_HUMAN
θ value	8.99809 (rank : 290)	NC score	0.037966 (rank : 292)
Query Neighborhood Hits	292	Target Neighborhood Hits	280	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASF4_HUMAN
θ value	8.99809 (rank : 291)	NC score	0.041560 (rank : 280)
Query Neighborhood Hits	292	Target Neighborhood Hits	282	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

ZN598_HUMAN
θ value	8.99809 (rank : 292)	NC score	0.023778 (rank : 336)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

ABI1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.068241 (rank : 119)
Query Neighborhood Hits	292	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.069201 (rank : 116)
Query Neighborhood Hits	292	Target Neighborhood Hits	246	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.073417 (rank : 105)
Query Neighborhood Hits	292	Target Neighborhood Hits	227	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.067004 (rank : 124)
Query Neighborhood Hits	292	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.059719 (rank : 162)
Query Neighborhood Hits	292	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.056662 (rank : 189)
Query Neighborhood Hits	292	Target Neighborhood Hits	1045	Shared Neighborhood Hits	76
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACK1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.054170 (rank : 216)
Query Neighborhood Hits	292	Target Neighborhood Hits	1140	Shared Neighborhood Hits	105
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.053711 (rank : 222)
Query Neighborhood Hits	292	Target Neighborhood Hits	1080	Shared Neighborhood Hits	103
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AHI1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.050949 (rank : 252)
Query Neighborhood Hits	292	Target Neighborhood Hits	537	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG4_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.066431 (rank : 126)
Query Neighborhood Hits	292	Target Neighborhood Hits	242	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.063887 (rank : 139)
Query Neighborhood Hits	292	Target Neighborhood Hits	185	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.062740 (rank : 147)
Query Neighborhood Hits	292	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.062168 (rank : 152)
Query Neighborhood Hits	292	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.053179 (rank : 226)
Query Neighborhood Hits	292	Target Neighborhood Hits	956	Shared Neighborhood Hits	92
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.058931 (rank : 171)
Query Neighborhood Hits	292	Target Neighborhood Hits	1244	Shared Neighborhood Hits	123
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.065726 (rank : 131)
Query Neighborhood Hits	292	Target Neighborhood Hits	554	Shared Neighborhood Hits	103
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.061995 (rank : 157)
Query Neighborhood Hits	292	Target Neighborhood Hits	438	Shared Neighborhood Hits	92
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BLK_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.055470 (rank : 203)
Query Neighborhood Hits	292	Target Neighborhood Hits	994	Shared Neighborhood Hits	80
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.055994 (rank : 194)
Query Neighborhood Hits	292	Target Neighborhood Hits	992	Shared Neighborhood Hits	76
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.059889 (rank : 161)
Query Neighborhood Hits	292	Target Neighborhood Hits	1026	Shared Neighborhood Hits	89
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.059574 (rank : 163)
Query Neighborhood Hits	292	Target Neighborhood Hits	1017	Shared Neighborhood Hits	89
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CSK_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.057684 (rank : 180)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	79
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.057253 (rank : 182)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	79
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.064632 (rank : 135)
Query Neighborhood Hits	292	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.059258 (rank : 165)
Query Neighborhood Hits	292	Target Neighborhood Hits	244	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.057914 (rank : 177)
Query Neighborhood Hits	292	Target Neighborhood Hits	306	Shared Neighborhood Hits	56
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.057101 (rank : 184)
Query Neighborhood Hits	292	Target Neighborhood Hits	592	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.053872 (rank : 219)
Query Neighborhood Hits	292	Target Neighborhood Hits	599	Shared Neighborhood Hits	87
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.055954 (rank : 197)
Query Neighborhood Hits	292	Target Neighborhood Hits	625	Shared Neighborhood Hits	86
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DNMBP_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.075584 (rank : 103)
Query Neighborhood Hits	292	Target Neighborhood Hits	413	Shared Neighborhood Hits	58
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.080122 (rank : 90)
Query Neighborhood Hits	292	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.058408 (rank : 174)
Query Neighborhood Hits	292	Target Neighborhood Hits	348	Shared Neighborhood Hits	85
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.057522 (rank : 181)
Query Neighborhood Hits	292	Target Neighborhood Hits	389	Shared Neighborhood Hits	85
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPHA3_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.077749 (rank : 99)
Query Neighborhood Hits	292	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.078188 (rank : 97)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ERBB2_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.050043 (rank : 260)
Query Neighborhood Hits	292	Target Neighborhood Hits	1073	Shared Neighborhood Hits	59
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

FER_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.050591 (rank : 256)
Query Neighborhood Hits	292	Target Neighborhood Hits	1278	Shared Neighborhood Hits	70
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGR_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.063060 (rank : 144)
Query Neighborhood Hits	292	Target Neighborhood Hits	1067	Shared Neighborhood Hits	90
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.062026 (rank : 156)
Query Neighborhood Hits	292	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FMN2_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.064523 (rank : 136)
Query Neighborhood Hits	292	Target Neighborhood Hits	484	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FRK_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.057114 (rank : 183)
Query Neighborhood Hits	292	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.062282 (rank : 151)
Query Neighborhood Hits	292	Target Neighborhood Hits	1078	Shared Neighborhood Hits	90
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.062973 (rank : 145)
Query Neighborhood Hits	292	Target Neighborhood Hits	1073	Shared Neighborhood Hits	90
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GRB2_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.091834 (rank : 60)
Query Neighborhood Hits	292	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.091606 (rank : 61)
Query Neighborhood Hits	292	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCK_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.059417 (rank : 164)
Query Neighborhood Hits	292	Target Neighborhood Hits	1035	Shared Neighborhood Hits	87
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.058947 (rank : 170)
Query Neighborhood Hits	292	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCLS1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.079014 (rank : 92)
Query Neighborhood Hits	292	Target Neighborhood Hits	329	Shared Neighborhood Hits	72
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.059893 (rank : 160)
Query Neighborhood Hits	292	Target Neighborhood Hits	688	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ILK1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.052118 (rank : 242)
Query Neighborhood Hits	292	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.052197 (rank : 241)
Query Neighborhood Hits	292	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.052409 (rank : 239)
Query Neighborhood Hits	292	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ITK_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.052482 (rank : 238)
Query Neighborhood Hits	292	Target Neighborhood Hits	1016	Shared Neighborhood Hits	79
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.051193 (rank : 248)
Query Neighborhood Hits	292	Target Neighborhood Hits	985	Shared Neighborhood Hits	69
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KSYK_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.051039 (rank : 250)
Query Neighborhood Hits	292	Target Neighborhood Hits	901	Shared Neighborhood Hits	54
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.052378 (rank : 240)
Query Neighborhood Hits	292	Target Neighborhood Hits	944	Shared Neighborhood Hits	64
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LCK_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.055713 (rank : 200)
Query Neighborhood Hits	292	Target Neighborhood Hits	987	Shared Neighborhood Hits	80
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.055816 (rank : 199)
Query Neighborhood Hits	292	Target Neighborhood Hits	981	Shared Neighborhood Hits	79
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LTK_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.050478 (rank : 257)
Query Neighborhood Hits	292	Target Neighborhood Hits	770	Shared Neighborhood Hits	42
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LYN_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.058281 (rank : 175)
Query Neighborhood Hits	292	Target Neighborhood Hits	1022	Shared Neighborhood Hits	88
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.057928 (rank : 176)
Query Neighborhood Hits	292	Target Neighborhood Hits	1023	Shared Neighborhood Hits	86
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.052796 (rank : 232)
Query Neighborhood Hits	292	Target Neighborhood Hits	1071	Shared Neighborhood Hits	91
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.062505 (rank : 149)
Query Neighborhood Hits	292	Target Neighborhood Hits	1136	Shared Neighborhood Hits	121
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3KL4_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.056383 (rank : 190)
Query Neighborhood Hits	292	Target Neighborhood Hits	1087	Shared Neighborhood Hits	93
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MATK_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.053090 (rank : 229)
Query Neighborhood Hits	292	Target Neighborhood Hits	954	Shared Neighborhood Hits	59
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.053277 (rank : 225)
Query Neighborhood Hits	292	Target Neighborhood Hits	952	Shared Neighborhood Hits	66
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MBD6_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.055672 (rank : 201)
Query Neighborhood Hits	292	Target Neighborhood Hits	349	Shared Neighborhood Hits	57
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MDC1_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.052709 (rank : 235)
Query Neighborhood Hits	292	Target Neighborhood Hits	1446	Shared Neighborhood Hits	103
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MUC1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.055991 (rank : 195)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	98
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NCF1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.085801 (rank : 84)
Query Neighborhood Hits	292	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF2_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.088344 (rank : 72)
Query Neighborhood Hits	292	Target Neighborhood Hits	229	Shared Neighborhood Hits	55
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.068675 (rank : 118)
Query Neighborhood Hits	292	Target Neighborhood Hits	161	Shared Neighborhood Hits	46
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.070750 (rank : 108)
Query Neighborhood Hits	292	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.096871 (rank : 49)
Query Neighborhood Hits	292	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NEBL_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.054948 (rank : 207)
Query Neighborhood Hits	292	Target Neighborhood Hits	457	Shared Neighborhood Hits	57
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.058654 (rank : 172)
Query Neighborhood Hits	292	Target Neighborhood Hits	114	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.063770 (rank : 141)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.054628 (rank : 210)
Query Neighborhood Hits	292	Target Neighborhood Hits	320	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.053924 (rank : 218)
Query Neighborhood Hits	292	Target Neighborhood Hits	283	Shared Neighborhood Hits	53
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.056717 (rank : 187)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.056274 (rank : 192)
Query Neighborhood Hits	292	Target Neighborhood Hits	382	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.053835 (rank : 220)
Query Neighborhood Hits	292	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.053791 (rank : 221)
Query Neighborhood Hits	292	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCLO_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.050697 (rank : 253)
Query Neighborhood Hits	292	Target Neighborhood Hits	2046	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PLCG1_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.064326 (rank : 137)
Query Neighborhood Hits	292	Target Neighborhood Hits	293	Shared Neighborhood Hits	55
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.065215 (rank : 133)
Query Neighborhood Hits	292	Target Neighborhood Hits	314	Shared Neighborhood Hits	57
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.057831 (rank : 178)
Query Neighborhood Hits	292	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.069276 (rank : 115)
Query Neighborhood Hits	292	Target Neighborhood Hits	389	Shared Neighborhood Hits	61
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.068085 (rank : 120)
Query Neighborhood Hits	292	Target Neighborhood Hits	377	Shared Neighborhood Hits	61
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRG4_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.063344 (rank : 143)
Query Neighborhood Hits	292	Target Neighborhood Hits	764	Shared Neighborhood Hits	60
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.054392 (rank : 213)
Query Neighborhood Hits	292	Target Neighborhood Hits	624	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.051750 (rank : 244)
Query Neighborhood Hits	292	Target Neighborhood Hits	385	Shared Neighborhood Hits	53
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRP2_MOUSE
θ value	θ > 10 (rank : 385)	NC score	0.054260 (rank : 215)
Query Neighborhood Hits	292	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRRT3_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.050684 (rank : 255)
Query Neighborhood Hits	292	Target Neighborhood Hits	998	Shared Neighborhood Hits	110
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTK6_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.054965 (rank : 206)
Query Neighborhood Hits	292	Target Neighborhood Hits	1020	Shared Neighborhood Hits	84
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.056346 (rank : 191)
Query Neighborhood Hits	292	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SET1A_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.059018 (rank : 169)
Query Neighborhood Hits	292	Target Neighborhood Hits	690	Shared Neighborhood Hits	59
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SFR15_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.055967 (rank : 196)
Query Neighborhood Hits	292	Target Neighborhood Hits	368	Shared Neighborhood Hits	41
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SH3G2_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.083335 (rank : 86)
Query Neighborhood Hits	292	Target Neighborhood Hits	324	Shared Neighborhood Hits	56
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.075682 (rank : 102)
Query Neighborhood Hits	292	Target Neighborhood Hits	222	Shared Neighborhood Hits	57
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.069510 (rank : 113)
Query Neighborhood Hits	292	Target Neighborhood Hits	1041	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SRC8_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.069820 (rank : 111)
Query Neighborhood Hits	292	Target Neighborhood Hits	269	Shared Neighborhood Hits	55
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.070245 (rank : 109)
Query Neighborhood Hits	292	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.060953 (rank : 158)
Query Neighborhood Hits	292	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.059080 (rank : 168)
Query Neighborhood Hits	292	Target Neighborhood Hits	1033	Shared Neighborhood Hits	85
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.051083 (rank : 249)
Query Neighborhood Hits	292	Target Neighborhood Hits	946	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.051676 (rank : 245)
Query Neighborhood Hits	292	Target Neighborhood Hits	964	Shared Neighborhood Hits	67
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM2_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.062131 (rank : 154)
Query Neighborhood Hits	292	Target Neighborhood Hits	1296	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STAC3_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.069591 (rank : 112)
Query Neighborhood Hits	292	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.069916 (rank : 110)
Query Neighborhood Hits	292	Target Neighborhood Hits	232	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.078321 (rank : 96)
Query Neighborhood Hits	292	Target Neighborhood Hits	271	Shared Neighborhood Hits	60
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.070850 (rank : 107)
Query Neighborhood Hits	292	Target Neighborhood Hits	273	Shared Neighborhood Hits	60
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.065638 (rank : 132)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	58
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.067227 (rank : 123)
Query Neighborhood Hits	292	Target Neighborhood Hits	285	Shared Neighborhood Hits	58
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TAF4_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.053099 (rank : 228)
Query Neighborhood Hits	292	Target Neighborhood Hits	687	Shared Neighborhood Hits	75
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARSH_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.063924 (rank : 138)
Query Neighborhood Hits	292	Target Neighborhood Hits	768	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TCGAP_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.052581 (rank : 237)
Query Neighborhood Hits	292	Target Neighborhood Hits	409	Shared Neighborhood Hits	91
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.055935 (rank : 198)
Query Neighborhood Hits	292	Target Neighborhood Hits	1006	Shared Neighborhood Hits	84
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.055488 (rank : 202)
Query Neighborhood Hits	292	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TNK1_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.050455 (rank : 258)
Query Neighborhood Hits	292	Target Neighborhood Hits	815	Shared Neighborhood Hits	53
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TXK_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.056133 (rank : 193)
Query Neighborhood Hits	292	Target Neighborhood Hits	971	Shared Neighborhood Hits	78
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.056991 (rank : 185)
Query Neighborhood Hits	292	Target Neighborhood Hits	980	Shared Neighborhood Hits	81
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WASIP_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.054064 (rank : 217)
Query Neighborhood Hits	292	Target Neighborhood Hits	392	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

YES_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.062642 (rank : 148)
Query Neighborhood Hits	292	Target Neighborhood Hits	1059	Shared Neighborhood Hits	90
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.062898 (rank : 146)
Query Neighborhood Hits	292	Target Neighborhood Hits	1052	Shared Neighborhood Hits	90
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.053124 (rank : 227)
Query Neighborhood Hits	292	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.052710 (rank : 234)
Query Neighborhood Hits	292	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

SASH1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	292	Target Neighborhood Hits	292	Shared Neighborhood Hits	292
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
NC score	0.951963 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	292	Target Neighborhood Hits	263	Shared Neighborhood Hits	138
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SLY_HUMAN
NC score	0.841303 (rank : 3)	θ value	5.92465e-60 (rank : 4)
Query Neighborhood Hits	292	Target Neighborhood Hits	81	Shared Neighborhood Hits	59
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
NC score	0.838390 (rank : 4)	θ value	6.32992e-62 (rank : 3)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SAMN1_HUMAN
NC score	0.820252 (rank : 5)	θ value	1.67352e-46 (rank : 5)
Query Neighborhood Hits	292	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
NC score	0.816983 (rank : 6)	θ value	5.03882e-43 (rank : 6)
Query Neighborhood Hits	292	Target Neighborhood Hits	69	Shared Neighborhood Hits	51
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

CD2AP_HUMAN
NC score	0.214843 (rank : 7)	θ value	0.000461057 (rank : 10)
Query Neighborhood Hits	292	Target Neighborhood Hits	315	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.187522 (rank : 8)	θ value	0.0193708 (rank : 26)
Query Neighborhood Hits	292	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CRK_MOUSE
NC score	0.183435 (rank : 9)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	292	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3K1_MOUSE
NC score	0.183192 (rank : 10)	θ value	0.0431538 (rank : 32)
Query Neighborhood Hits	292	Target Neighborhood Hits	332	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CRK_HUMAN
NC score	0.178129 (rank : 11)	θ value	0.0330416 (rank : 29)
Query Neighborhood Hits	292	Target Neighborhood Hits	308	Shared Neighborhood Hits	65
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.171886 (rank : 12)	θ value	0.0961366 (rank : 37)
Query Neighborhood Hits	292	Target Neighborhood Hits	313	Shared Neighborhood Hits	67
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.171647 (rank : 13)	θ value	0.0961366 (rank : 38)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CD2AP_MOUSE
NC score	0.171493 (rank : 14)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	292	Target Neighborhood Hits	336	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GRAP_HUMAN
NC score	0.150981 (rank : 15)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ANKS1_MOUSE
NC score	0.149689 (rank : 16)	θ value	0.00035302 (rank : 8)
Query Neighborhood Hits	292	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ARHG6_HUMAN
NC score	0.146084 (rank : 17)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	292	Target Neighborhood Hits	376	Shared Neighborhood Hits	64
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ANKS1_HUMAN
NC score	0.145889 (rank : 18)	θ value	2.44474e-05 (rank : 7)
Query Neighborhood Hits	292	Target Neighborhood Hits	438	Shared Neighborhood Hits	58
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ARHG7_HUMAN
NC score	0.143723 (rank : 19)	θ value	0.0431538 (rank : 31)
Query Neighborhood Hits	292	Target Neighborhood Hits	347	Shared Neighborhood Hits	64
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.140090 (rank : 20)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	292	Target Neighborhood Hits	396	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG6_MOUSE
NC score	0.137954 (rank : 21)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	292	Target Neighborhood Hits	394	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

GRAP_MOUSE
NC score	0.135421 (rank : 22)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	292	Target Neighborhood Hits	309	Shared Neighborhood Hits	67
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CSKI1_MOUSE
NC score	0.131243 (rank : 23)	θ value	0.0563607 (rank : 34)
Query Neighborhood Hits	292	Target Neighborhood Hits	1031	Shared Neighborhood Hits	161
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.131138 (rank : 24)	θ value	0.0563607 (rank : 33)
Query Neighborhood Hits	292	Target Neighborhood Hits	997	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

VAV_MOUSE
NC score	0.125690 (rank : 25)	θ value	0.125558 (rank : 45)
Query Neighborhood Hits	292	Target Neighborhood Hits	430	Shared Neighborhood Hits	64
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.125313 (rank : 26)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	292	Target Neighborhood Hits	452	Shared Neighborhood Hits	63
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

NCK2_HUMAN
NC score	0.125258 (rank : 27)	θ value	0.813845 (rank : 95)
Query Neighborhood Hits	292	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

CSKI2_MOUSE
NC score	0.123200 (rank : 28)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	292	Target Neighborhood Hits	812	Shared Neighborhood Hits	120
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_HUMAN
NC score	0.122425 (rank : 29)	θ value	0.00665767 (rank : 19)
Query Neighborhood Hits	292	Target Neighborhood Hits	747	Shared Neighborhood Hits	123
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

STAC_HUMAN
NC score	0.119669 (rank : 30)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	292	Target Neighborhood Hits	276	Shared Neighborhood Hits	66
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
NC score	0.117424 (rank : 31)	θ value	1.81305 (rank : 137)
Query Neighborhood Hits	292	Target Neighborhood Hits	268	Shared Neighborhood Hits	66
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.114180 (rank : 32)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	292	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP2_MOUSE
NC score	0.113131 (rank : 33)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	292	Target Neighborhood Hits	297	Shared Neighborhood Hits	63
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SRBS1_MOUSE
NC score	0.111765 (rank : 34)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	292	Target Neighborhood Hits	409	Shared Neighborhood Hits	73
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

EPHB6_MOUSE
NC score	0.110919 (rank : 35)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	292	Target Neighborhood Hits	906	Shared Neighborhood Hits	57
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

VAV3_HUMAN
NC score	0.109538 (rank : 36)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	292	Target Neighborhood Hits	398	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

EPHB6_HUMAN
NC score	0.109130 (rank : 37)	θ value	0.00509761 (rank : 18)
Query Neighborhood Hits	292	Target Neighborhood Hits	912	Shared Neighborhood Hits	58
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

VINEX_HUMAN
NC score	0.108523 (rank : 38)	θ value	8.99809 (rank : 288)
Query Neighborhood Hits	292	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G3_MOUSE
NC score	0.107502 (rank : 39)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	292	Target Neighborhood Hits	236	Shared Neighborhood Hits	59
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VAV3_MOUSE
NC score	0.107042 (rank : 40)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	292	Target Neighborhood Hits	404	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GRAP2_HUMAN
NC score	0.105623 (rank : 41)	θ value	2.36792 (rank : 143)
Query Neighborhood Hits	292	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

VINEX_MOUSE
NC score	0.104324 (rank : 42)	θ value	6.88961 (rank : 246)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ITSN1_HUMAN
NC score	0.101517 (rank : 43)	θ value	0.0193708 (rank : 25)
Query Neighborhood Hits	292	Target Neighborhood Hits	1757	Shared Neighborhood Hits	119
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABI2_HUMAN
NC score	0.101165 (rank : 44)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	292	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

EPHA6_MOUSE
NC score	0.098625 (rank : 45)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	292	Target Neighborhood Hits	946	Shared Neighborhood Hits	52
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

VAV2_MOUSE
NC score	0.098475 (rank : 46)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	292	Target Neighborhood Hits	456	Shared Neighborhood Hits	60
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.098460 (rank : 47)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	292	Target Neighborhood Hits	453	Shared Neighborhood Hits	60
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

EPHA6_HUMAN
NC score	0.098061 (rank : 48)	θ value	0.0563607 (rank : 35)
Query Neighborhood Hits	292	Target Neighborhood Hits	959	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

NCK1_HUMAN
NC score	0.096871 (rank : 49)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	292	Target Neighborhood Hits	312	Shared Neighborhood Hits	58
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ABI2_MOUSE
NC score	0.096739 (rank : 50)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	292	Target Neighborhood Hits	266	Shared Neighborhood Hits	65
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

EPHA4_MOUSE
NC score	0.096263 (rank : 51)	θ value	0.00035302 (rank : 9)
Query Neighborhood Hits	292	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

SH3G2_MOUSE
NC score	0.095640 (rank : 52)	θ value	8.99809 (rank : 281)
Query Neighborhood Hits	292	Target Neighborhood Hits	319	Shared Neighborhood Hits	60
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NCF1_MOUSE
NC score	0.095475 (rank : 53)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	292	Target Neighborhood Hits	198	Shared Neighborhood Hits	54
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

EPHA4_HUMAN
NC score	0.095379 (rank : 54)	θ value	0.000786445 (rank : 12)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	53
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA7_HUMAN
NC score	0.094116 (rank : 55)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	292	Target Neighborhood Hits	1053	Shared Neighborhood Hits	56
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHAA_HUMAN
NC score	0.094004 (rank : 56)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	292	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHA7_MOUSE
NC score	0.093706 (rank : 57)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	292	Target Neighborhood Hits	1025	Shared Neighborhood Hits	55
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA5_HUMAN
NC score	0.093223 (rank : 58)	θ value	0.125558 (rank : 42)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	56
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ITSN1_MOUSE
NC score	0.093069 (rank : 59)	θ value	0.365318 (rank : 65)
Query Neighborhood Hits	292	Target Neighborhood Hits	1669	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

GRB2_HUMAN
NC score	0.091834 (rank : 60)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	292	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.091606 (rank : 61)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	292	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

TPO_MOUSE
NC score	0.091564 (rank : 62)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	292	Target Neighborhood Hits	258	Shared Neighborhood Hits	41
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

EPHB3_HUMAN
NC score	0.091124 (rank : 63)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	292	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB1_HUMAN
NC score	0.090257 (rank : 64)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	292	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA1_MOUSE
NC score	0.089769 (rank : 65)	θ value	0.125558 (rank : 41)
Query Neighborhood Hits	292	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB4_MOUSE
NC score	0.089273 (rank : 66)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	292	Target Neighborhood Hits	1013	Shared Neighborhood Hits	56
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

OSTF1_MOUSE
NC score	0.089127 (rank : 67)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	292	Target Neighborhood Hits	467	Shared Neighborhood Hits	68
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

EPHB3_MOUSE
NC score	0.088858 (rank : 68)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	292	Target Neighborhood Hits	996	Shared Neighborhood Hits	55
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
NC score	0.088473 (rank : 69)	θ value	0.125558 (rank : 43)
Query Neighborhood Hits	292	Target Neighborhood Hits	1056	Shared Neighborhood Hits	56
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

HCLS1_HUMAN
NC score	0.088449 (rank : 70)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	292	Target Neighborhood Hits	358	Shared Neighborhood Hits	81
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

EPHA8_MOUSE
NC score	0.088368 (rank : 71)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	292	Target Neighborhood Hits	969	Shared Neighborhood Hits	54
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

NCF2_HUMAN
NC score	0.088344 (rank : 72)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	292	Target Neighborhood Hits	229	Shared Neighborhood Hits	55
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

EPHB2_HUMAN
NC score	0.088334 (rank : 73)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	292	Target Neighborhood Hits	983	Shared Neighborhood Hits	54
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

OSTF1_HUMAN
NC score	0.088157 (rank : 74)	θ value	8.99809 (rank : 272)
Query Neighborhood Hits	292	Target Neighborhood Hits	466	Shared Neighborhood Hits	68
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

EPHA2_MOUSE
NC score	0.088126 (rank : 75)	θ value	3.0926 (rank : 162)
Query Neighborhood Hits	292	Target Neighborhood Hits	1020	Shared Neighborhood Hits	58
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB2_MOUSE
NC score	0.088004 (rank : 76)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	292	Target Neighborhood Hits	982	Shared Neighborhood Hits	54
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA1_HUMAN
NC score	0.087719 (rank : 77)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	292	Target Neighborhood Hits	997	Shared Neighborhood Hits	57
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

ITSN2_HUMAN
NC score	0.087418 (rank : 78)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	292	Target Neighborhood Hits	1173	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

EPHA8_HUMAN
NC score	0.087186 (rank : 79)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	292	Target Neighborhood Hits	956	Shared Neighborhood Hits	52
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ITSN2_MOUSE
NC score	0.087160 (rank : 80)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	292	Target Neighborhood Hits	1371	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYO1E_HUMAN
NC score	0.086854 (rank : 81)	θ value	0.000461057 (rank : 11)
Query Neighborhood Hits	292	Target Neighborhood Hits	293	Shared Neighborhood Hits	61
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SHAN2_MOUSE
NC score	0.086681 (rank : 82)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	292	Target Neighborhood Hits	446	Shared Neighborhood Hits	104
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

EPHA2_HUMAN
NC score	0.086372 (rank : 83)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	292	Target Neighborhood Hits	1021	Shared Neighborhood Hits	57
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

NCF1_HUMAN
NC score	0.085801 (rank : 84)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	292	Target Neighborhood Hits	198	Shared Neighborhood Hits	55
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_MOUSE
NC score	0.084616 (rank : 85)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	292	Target Neighborhood Hits	267	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SH3G2_HUMAN
NC score	0.083335 (rank : 86)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	292	Target Neighborhood Hits	324	Shared Neighborhood Hits	56
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_MOUSE
NC score	0.082444 (rank : 87)	θ value	8.99809 (rank : 280)
Query Neighborhood Hits	292	Target Neighborhood Hits	291	Shared Neighborhood Hits	60
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

PRR13_HUMAN
NC score	0.080901 (rank : 88)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	292	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

SH3G1_HUMAN
NC score	0.080187 (rank : 89)	θ value	8.99809 (rank : 279)
Query Neighborhood Hits	292	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

DNMBP_MOUSE
NC score	0.080122 (rank : 90)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	292	Target Neighborhood Hits	435	Shared Neighborhood Hits	69
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CASG_MOUSE
NC score	0.079667 (rank : 91)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	292	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02862	Gene names	Csng
Domain Architecture	No domain graphic available
Description	Gamma-casein precursor (PP22).

HCLS1_MOUSE
NC score	0.079014 (rank : 92)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	292	Target Neighborhood Hits	329	Shared Neighborhood Hits	72
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

PRR12_HUMAN
NC score	0.078619 (rank : 93)	θ value	8.99809 (rank : 276)
Query Neighborhood Hits	292	Target Neighborhood Hits	460	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

TRDN_HUMAN
NC score	0.078468 (rank : 94)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	292	Target Neighborhood Hits	542	Shared Neighborhood Hits	29
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

EPHA5_MOUSE
NC score	0.078397 (rank : 95)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	292	Target Neighborhood Hits	950	Shared Neighborhood Hits	54
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

STAM1_HUMAN
NC score	0.078321 (rank : 96)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	292	Target Neighborhood Hits	271	Shared Neighborhood Hits	60
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

EPHA3_MOUSE
NC score	0.078188 (rank : 97)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

CEND1_HUMAN
NC score	0.077798 (rank : 98)	θ value	0.163984 (rank : 48)
Query Neighborhood Hits	292	Target Neighborhood Hits	284	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

EPHA3_HUMAN
NC score	0.077749 (rank : 99)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	292	Target Neighborhood Hits	1005	Shared Neighborhood Hits	45
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

NACAM_MOUSE
NC score	0.077040 (rank : 100)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	292	Target Neighborhood Hits	1866	Shared Neighborhood Hits	140
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

WASIP_HUMAN
NC score	0.076329 (rank : 101)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	292	Target Neighborhood Hits	458	Shared Neighborhood Hits	65
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SH3G3_HUMAN
NC score	0.075682 (rank : 102)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	292	Target Neighborhood Hits	222	Shared Neighborhood Hits	57
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

DNMBP_HUMAN
NC score	0.075584 (rank : 103)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	292	Target Neighborhood Hits	413	Shared Neighborhood Hits	58
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

OGFR_HUMAN
NC score	0.075446 (rank : 104)	θ value	0.125558 (rank : 44)
Query Neighborhood Hits	292	Target Neighborhood Hits	1582	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ABI3_HUMAN
NC score	0.073417 (rank : 105)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	292	Target Neighborhood Hits	227	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

IASPP_MOUSE
NC score	0.071007 (rank : 106)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	292	Target Neighborhood Hits	1024	Shared Neighborhood Hits	125
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

STAM1_MOUSE
NC score	0.070850 (rank : 107)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	292	Target Neighborhood Hits	273	Shared Neighborhood Hits	60
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_MOUSE
NC score	0.070750 (rank : 108)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	292	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRC8_MOUSE
NC score	0.070245 (rank : 109)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	292	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_MOUSE
NC score	0.069916 (rank : 110)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	292	Target Neighborhood Hits	232	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRC8_HUMAN
NC score	0.069820 (rank : 111)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	292	Target Neighborhood Hits	269	Shared Neighborhood Hits	55
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAC3_HUMAN
NC score	0.069591 (rank : 112)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	292	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SHAN1_HUMAN
NC score	0.069510 (rank : 113)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	292	Target Neighborhood Hits	1041	Shared Neighborhood Hits	129
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GSCR1_HUMAN
NC score	0.069433 (rank : 114)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	292	Target Neighborhood Hits	674	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

PPIP1_HUMAN
NC score	0.069276 (rank : 115)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	292	Target Neighborhood Hits	389	Shared Neighborhood Hits	61
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI1_MOUSE
NC score	0.069201 (rank : 116)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	292	Target Neighborhood Hits	246	Shared Neighborhood Hits	59
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

MYO1F_HUMAN
NC score	0.068980 (rank : 117)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	292	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCF4_HUMAN
NC score	0.068675 (rank : 118)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	292	Target Neighborhood Hits	161	Shared Neighborhood Hits	46
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI1_HUMAN
NC score	0.068241 (rank : 119)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	292	Target Neighborhood Hits	257	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PPIP1_MOUSE
NC score	0.068085 (rank : 120)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	292	Target Neighborhood Hits	377	Shared Neighborhood Hits	61
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

M3K9_HUMAN
NC score	0.067693 (rank : 121)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	292	Target Neighborhood Hits	1123	Shared Neighborhood Hits	103
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SON_HUMAN
NC score	0.067288 (rank : 122)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	292	Target Neighborhood Hits	1568	Shared Neighborhood Hits	135
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

STAM2_MOUSE
NC score	0.067227 (rank : 123)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	292	Target Neighborhood Hits	285	Shared Neighborhood Hits	58
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ABI3_MOUSE
NC score	0.067004 (rank : 124)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	292	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TMAP1_HUMAN
NC score	0.066896 (rank : 125)	θ value	1.81305 (rank : 138)
Query Neighborhood Hits	292	Target Neighborhood Hits	140	Shared Neighborhood Hits	25
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

ARHG4_HUMAN
NC score	0.066431 (rank : 126)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	292	Target Neighborhood Hits	242	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TCGAP_HUMAN
NC score	0.066123 (rank : 127)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	292	Target Neighborhood Hits	872	Shared Neighborhood Hits	137
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

WBP11_HUMAN
NC score	0.065963 (rank : 128)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	292	Target Neighborhood Hits	354	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
NC score	0.065955 (rank : 129)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	292	Target Neighborhood Hits	362	Shared Neighborhood Hits	58
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ABL1_MOUSE
NC score	0.065830 (rank : 130)	θ value	0.0252991 (rank : 27)
Query Neighborhood Hits	292	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BCAR1_HUMAN
NC score	0.065726 (rank : 131)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	292	Target Neighborhood Hits	554	Shared Neighborhood Hits	103
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STAM2_HUMAN
NC score	0.065638 (rank : 132)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	58
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PLCG1_MOUSE
NC score	0.065215 (rank : 133)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	292	Target Neighborhood Hits	314	Shared Neighborhood Hits	57
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CEND3_HUMAN
NC score	0.064646 (rank : 134)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	292	Target Neighborhood Hits	275	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CT032_HUMAN
NC score	0.064632 (rank : 135)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	292	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

FMN2_HUMAN
NC score	0.064523 (rank : 136)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	292	Target Neighborhood Hits	484	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

PLCG1_HUMAN
NC score	0.064326 (rank : 137)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	292	Target Neighborhood Hits	293	Shared Neighborhood Hits	55
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

TARSH_HUMAN
NC score	0.063924 (rank : 138)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	292	Target Neighborhood Hits	768	Shared Neighborhood Hits	108
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ARHG4_MOUSE
NC score	0.063887 (rank : 139)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	292	Target Neighborhood Hits	185	Shared Neighborhood Hits	49
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NCOA6_HUMAN
NC score	0.063818 (rank : 140)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	292	Target Neighborhood Hits	1202	Shared Neighborhood Hits	116
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NPHP1_HUMAN
NC score	0.063770 (rank : 141)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SRRM2_MOUSE
NC score	0.063727 (rank : 142)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	292	Target Neighborhood Hits	1470	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PRG4_HUMAN
NC score	0.063344 (rank : 143)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	292	Target Neighborhood Hits	764	Shared Neighborhood Hits	60
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FGR_HUMAN
NC score	0.063060 (rank : 144)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	292	Target Neighborhood Hits	1067	Shared Neighborhood Hits	90
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_MOUSE
NC score	0.062973 (rank : 145)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	292	Target Neighborhood Hits	1073	Shared Neighborhood Hits	90
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

YES_MOUSE
NC score	0.062898 (rank : 146)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	292	Target Neighborhood Hits	1052	Shared Neighborhood Hits	90
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG9_HUMAN
NC score	0.062740 (rank : 147)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	292	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

YES_HUMAN
NC score	0.062642 (rank : 148)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	292	Target Neighborhood Hits	1059	Shared Neighborhood Hits	90
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M3K11_HUMAN
NC score	0.062505 (rank : 149)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	292	Target Neighborhood Hits	1136	Shared Neighborhood Hits	121
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CEND3_MOUSE
NC score	0.062469 (rank : 150)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	292	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

FYN_HUMAN
NC score	0.062282 (rank : 151)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	292	Target Neighborhood Hits	1078	Shared Neighborhood Hits	90
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

ARHG9_MOUSE
NC score	0.062168 (rank : 152)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	292	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CEND1_MOUSE
NC score	0.062144 (rank : 153)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	292	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

SRRM2_HUMAN
NC score	0.062131 (rank : 154)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	292	Target Neighborhood Hits	1296	Shared Neighborhood Hits	92
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

LCP2_HUMAN
NC score	0.062100 (rank : 155)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	292	Target Neighborhood Hits	531	Shared Neighborhood Hits	65
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

FGR_MOUSE
NC score	0.062026 (rank : 156)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	292	Target Neighborhood Hits	1069	Shared Neighborhood Hits	90
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BCAR1_MOUSE
NC score	0.061995 (rank : 157)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	292	Target Neighborhood Hits	438	Shared Neighborhood Hits	92
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SRC_HUMAN
NC score	0.060953 (rank : 158)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	292	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

IF2P_HUMAN
NC score	0.060850 (rank : 159)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	292	Target Neighborhood Hits	889	Shared Neighborhood Hits	29
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IASPP_HUMAN
NC score	0.059893 (rank : 160)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	292	Target Neighborhood Hits	688	Shared Neighborhood Hits	97
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BTK_HUMAN
NC score	0.059889 (rank : 161)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	292	Target Neighborhood Hits	1026	Shared Neighborhood Hits	89
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ABL1_HUMAN
NC score	0.059719 (rank : 162)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	292	Target Neighborhood Hits	1220	Shared Neighborhood Hits	100
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BTK_MOUSE
NC score	0.059574 (rank : 163)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	292	Target Neighborhood Hits	1017	Shared Neighborhood Hits	89
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCK_HUMAN
NC score	0.059417 (rank : 164)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	292	Target Neighborhood Hits	1035	Shared Neighborhood Hits	87
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

DBNL_HUMAN
NC score	0.059258 (rank : 165)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	292	Target Neighborhood Hits	244	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SMR1_MOUSE
NC score	0.059223 (rank : 166)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	292	Target Neighborhood Hits	103	Shared Neighborhood Hits	25
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

ENAH_MOUSE
NC score	0.059149 (rank : 167)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	292	Target Neighborhood Hits	919	Shared Neighborhood Hits	80
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

SRC_MOUSE
NC score	0.059080 (rank : 168)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	292	Target Neighborhood Hits	1033	Shared Neighborhood Hits	85
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SET1A_HUMAN
NC score	0.059018 (rank : 169)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	292	Target Neighborhood Hits	690	Shared Neighborhood Hits	59
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

HCK_MOUSE
NC score	0.058947 (rank : 170)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	292	Target Neighborhood Hits	1029	Shared Neighborhood Hits	87
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ASPP1_MOUSE
NC score	0.058931 (rank : 171)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	292	Target Neighborhood Hits	1244	Shared Neighborhood Hits	123
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NOXO1_MOUSE
NC score	0.058654 (rank : 172)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	292	Target Neighborhood Hits	114	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

BSN_MOUSE
NC score	0.058435 (rank : 173)	θ value	3.0926 (rank : 159)
Query Neighborhood Hits	292	Target Neighborhood Hits	2057	Shared Neighborhood Hits	136
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

EFS_HUMAN
NC score	0.058408 (rank : 174)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	292	Target Neighborhood Hits	348	Shared Neighborhood Hits	85
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

LYN_HUMAN
NC score	0.058281 (rank : 175)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	292	Target Neighborhood Hits	1022	Shared Neighborhood Hits	88
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.057928 (rank : 176)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	292	Target Neighborhood Hits	1023	Shared Neighborhood Hits	86
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

DBNL_MOUSE
NC score	0.057914 (rank : 177)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	292	Target Neighborhood Hits	306	Shared Neighborhood Hits	56
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PLCG2_HUMAN
NC score	0.057831 (rank : 178)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	292	Target Neighborhood Hits	280	Shared Neighborhood Hits	54
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

AL2S4_MOUSE
NC score	0.057771 (rank : 179)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	292	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

CSK_HUMAN
NC score	0.057684 (rank : 180)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	79
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

EFS_MOUSE
NC score	0.057522 (rank : 181)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	292	Target Neighborhood Hits	389	Shared Neighborhood Hits	85
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

CSK_MOUSE
NC score	0.057253 (rank : 182)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	292	Target Neighborhood Hits	1009	Shared Neighborhood Hits	79
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

FRK_HUMAN
NC score	0.057114 (rank : 183)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	292	Target Neighborhood Hits	1058	Shared Neighborhood Hits	88
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

DDEF1_MOUSE
NC score	0.057101 (rank : 184)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	292	Target Neighborhood Hits	592	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

TXK_MOUSE
NC score	0.056991 (rank : 185)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	292	Target Neighborhood Hits	980	Shared Neighborhood Hits	81
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

MAP1B_HUMAN
NC score	0.056880 (rank : 186)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	292	Target Neighborhood Hits	903	Shared Neighborhood Hits	43
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

PACN2_HUMAN
NC score	0.056717 (rank : 187)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

BCL9_HUMAN
NC score	0.056712 (rank : 188)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	292	Target Neighborhood Hits	1008	Shared Neighborhood Hits	109
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

ABL2_HUMAN
NC score	0.056662 (rank : 189)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	292	Target Neighborhood Hits	1045	Shared Neighborhood Hits	76
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

M3KL4_HUMAN
NC score	0.056383 (rank : 190)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	292	Target Neighborhood Hits	1087	Shared Neighborhood Hits	93
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PTK6_MOUSE
NC score	0.056346 (rank : 191)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	292	Target Neighborhood Hits	1026	Shared Neighborhood Hits	87
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PACN2_MOUSE
NC score	0.056274 (rank : 192)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	292	Target Neighborhood Hits	382	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

TXK_HUMAN
NC score	0.056133 (rank : 193)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	292	Target Neighborhood Hits	971	Shared Neighborhood Hits	78
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BLK_MOUSE
NC score	0.055994 (rank : 194)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	292	Target Neighborhood Hits	992	Shared Neighborhood Hits	76
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MUC1_HUMAN
NC score	0.055991 (rank : 195)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	98
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SFR15_HUMAN
NC score	0.055967 (rank : 196)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	292	Target Neighborhood Hits	368	Shared Neighborhood Hits	41
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

DDEF2_MOUSE
NC score	0.055954 (rank : 197)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	292	Target Neighborhood Hits	625	Shared Neighborhood Hits	86
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TEC_HUMAN
NC score	0.055935 (rank : 198)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	292	Target Neighborhood Hits	1006	Shared Neighborhood Hits	84
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

LCK_MOUSE
NC score	0.055816 (rank : 199)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	292	Target Neighborhood Hits	981	Shared Neighborhood Hits	79
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCK_HUMAN
NC score	0.055713 (rank : 200)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	292	Target Neighborhood Hits	987	Shared Neighborhood Hits	80
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MBD6_HUMAN
NC score	0.055672 (rank : 201)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	292	Target Neighborhood Hits	349	Shared Neighborhood Hits	57
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

TEC_MOUSE
NC score	0.055488 (rank : 202)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	292	Target Neighborhood Hits	1006	Shared Neighborhood Hits	83
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
NC score	0.055470 (rank : 203)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	292	Target Neighborhood Hits	994	Shared Neighborhood Hits	80
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MAVS_HUMAN
NC score	0.055277 (rank : 204)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	292	Target Neighborhood Hits	271	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SF3A2_HUMAN
NC score	0.055034 (rank : 205)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	292	Target Neighborhood Hits	263	Shared Neighborhood Hits	44
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

PTK6_HUMAN
NC score	0.054965 (rank : 206)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	292	Target Neighborhood Hits	1020	Shared Neighborhood Hits	84
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

NEBL_HUMAN
NC score	0.054948 (rank : 207)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	292	Target Neighborhood Hits	457	Shared Neighborhood Hits	57
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

TM108_MOUSE
NC score	0.054941 (rank : 208)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	292	Target Neighborhood Hits	336	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

FMN1B_MOUSE
NC score	0.054685 (rank : 209)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	292	Target Neighborhood Hits	447	Shared Neighborhood Hits	58
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

PACN1_HUMAN
NC score	0.054628 (rank : 210)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	292	Target Neighborhood Hits	320	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

LCP2_MOUSE
NC score	0.054471 (rank : 211)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	292	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BAT2_HUMAN
NC score	0.054456 (rank : 212)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	292	Target Neighborhood Hits	931	Shared Neighborhood Hits	101
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PRG4_MOUSE
NC score	0.054392 (rank : 213)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	292	Target Neighborhood Hits	624	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

MYO1F_MOUSE
NC score	0.054303 (rank : 214)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	292	Target Neighborhood Hits	262	Shared Neighborhood Hits	59
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PRP2_MOUSE
NC score	0.054260 (rank : 215)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	292	Target Neighborhood Hits	347	Shared Neighborhood Hits	48
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

ACK1_HUMAN
NC score	0.054170 (rank : 216)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	292	Target Neighborhood Hits	1140	Shared Neighborhood Hits	105
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

WASIP_MOUSE
NC score	0.054064 (rank : 217)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	292	Target Neighborhood Hits	392	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

PACN1_MOUSE
NC score	0.053924 (rank : 218)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	292	Target Neighborhood Hits	283	Shared Neighborhood Hits	53
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

DDEF2_HUMAN
NC score	0.053872 (rank : 219)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	292	Target Neighborhood Hits	599	Shared Neighborhood Hits	87
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PACN3_HUMAN
NC score	0.053835 (rank : 220)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	292	Target Neighborhood Hits	385	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.053791 (rank : 221)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	292	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ACK1_MOUSE
NC score	0.053711 (rank : 222)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	292	Target Neighborhood Hits	1080	Shared Neighborhood Hits	103
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

FMN1A_MOUSE
NC score	0.053699 (rank : 223)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	292	Target Neighborhood Hits	423	Shared Neighborhood Hits	54
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

PHC2_HUMAN
NC score	0.053612 (rank : 224)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	292	Target Neighborhood Hits	388	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

MATK_MOUSE
NC score	0.053277 (rank : 225)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	292	Target Neighborhood Hits	952	Shared Neighborhood Hits	66
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

ASPP1_HUMAN
NC score	0.053179 (rank : 226)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	292	Target Neighborhood Hits	956	Shared Neighborhood Hits	92
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ZAP70_HUMAN
NC score	0.053124 (rank : 227)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	292	Target Neighborhood Hits	893	Shared Neighborhood Hits	57
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TAF4_HUMAN
NC score	0.053099 (rank : 228)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	292	Target Neighborhood Hits	687	Shared Neighborhood Hits	75
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

MATK_HUMAN
NC score	0.053090 (rank : 229)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	292	Target Neighborhood Hits	954	Shared Neighborhood Hits	59
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

WASP_MOUSE
NC score	0.052939 (rank : 230)	θ value	1.81305 (rank : 139)
Query Neighborhood Hits	292	Target Neighborhood Hits	223	Shared Neighborhood Hits	47
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

NFH_MOUSE
NC score	0.052870 (rank : 231)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	292	Target Neighborhood Hits	2247	Shared Neighborhood Hits	140
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

M3K10_HUMAN
NC score	0.052796 (rank : 232)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	292	Target Neighborhood Hits	1071	Shared Neighborhood Hits	91
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SF3A2_MOUSE
NC score	0.052744 (rank : 233)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	292	Target Neighborhood Hits	247	Shared Neighborhood Hits	39
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

ZAP70_MOUSE
NC score	0.052710 (rank : 234)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	292	Target Neighborhood Hits	905	Shared Neighborhood Hits	57
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MDC1_HUMAN
NC score	0.052709 (rank : 235)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	292	Target Neighborhood Hits	1446	Shared Neighborhood Hits	103
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

GGN_MOUSE
NC score	0.052679 (rank : 236)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	292	Target Neighborhood Hits	311	Shared Neighborhood Hits	52
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

TCGAP_MOUSE
NC score	0.052581 (rank : 237)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	292	Target Neighborhood Hits	409	Shared Neighborhood Hits	91
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ITK_HUMAN
NC score	0.052482 (rank : 238)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	292	Target Neighborhood Hits	1016	Shared Neighborhood Hits	79
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ILK_MOUSE
NC score	0.052409 (rank : 239)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	292	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

KSYK_MOUSE
NC score	0.052378 (rank : 240)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	292	Target Neighborhood Hits	944	Shared Neighborhood Hits	64
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ILK2_HUMAN
NC score	0.052197 (rank : 241)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	292	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK1_HUMAN
NC score	0.052118 (rank : 242)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	292	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

IWS1_MOUSE
NC score	0.051794 (rank : 243)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	292	Target Neighborhood Hits	1258	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PRP1_HUMAN
NC score	0.051750 (rank : 244)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	292	Target Neighborhood Hits	385	Shared Neighborhood Hits	53
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

SRMS_MOUSE
NC score	0.051676 (rank : 245)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	292	Target Neighborhood Hits	964	Shared Neighborhood Hits	67
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

FMNL_HUMAN
NC score	0.051416 (rank : 246)	θ value	1.06291 (rank : 102)
Query Neighborhood Hits	292	Target Neighborhood Hits	529	Shared Neighborhood Hits	55
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

RGS3_MOUSE
NC score	0.051259 (rank : 247)	θ value	8.99809 (rank : 278)
Query Neighborhood Hits	292	Target Neighborhood Hits	1621	Shared Neighborhood Hits	132
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ITK_MOUSE
NC score	0.051193 (rank : 248)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	292	Target Neighborhood Hits	985	Shared Neighborhood Hits	69
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SRMS_HUMAN
NC score	0.051083 (rank : 249)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	292	Target Neighborhood Hits	946	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

KSYK_HUMAN
NC score	0.051039 (rank : 250)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	292	Target Neighborhood Hits	901	Shared Neighborhood Hits	54
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NCOA6_MOUSE
NC score	0.050978 (rank : 251)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	292	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

AHI1_HUMAN
NC score	0.050949 (rank : 252)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	292	Target Neighborhood Hits	537	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PCLO_HUMAN
NC score	0.050697 (rank : 253)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	292	Target Neighborhood Hits	2046	Shared Neighborhood Hits	138
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PXK_MOUSE
NC score	0.050685 (rank : 254)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	292	Target Neighborhood Hits	320	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PRRT3_HUMAN
NC score	0.050684 (rank : 255)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	292	Target Neighborhood Hits	998	Shared Neighborhood Hits	110
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

FER_HUMAN
NC score	0.050591 (rank : 256)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	292	Target Neighborhood Hits	1278	Shared Neighborhood Hits	70
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

LTK_MOUSE
NC score	0.050478 (rank : 257)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	292	Target Neighborhood Hits	770	Shared Neighborhood Hits	42
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

TNK1_HUMAN
NC score	0.050455 (rank : 258)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	292	Target Neighborhood Hits	815	Shared Neighborhood Hits	53
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

WASL_MOUSE
NC score	0.050347 (rank : 259)	θ value	6.88961 (rank : 247)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ERBB2_HUMAN
NC score	0.050043 (rank : 260)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	292	Target Neighborhood Hits	1073	Shared Neighborhood Hits	59
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

AATK_HUMAN
NC score	0.049948 (rank : 261)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	292	Target Neighborhood Hits	1243	Shared Neighborhood Hits	97
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

K1802_MOUSE
NC score	0.049602 (rank : 262)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	292	Target Neighborhood Hits	1596	Shared Neighborhood Hits	112
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MINT_MOUSE
NC score	0.048895 (rank : 263)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	292	Target Neighborhood Hits	1514	Shared Neighborhood Hits	113
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MDC1_MOUSE
NC score	0.048611 (rank : 264)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	292	Target Neighborhood Hits	998	Shared Neighborhood Hits	87
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

SHAN2_HUMAN
NC score	0.048404 (rank : 265)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	292	Target Neighborhood Hits	346	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

MNT_MOUSE
NC score	0.048117 (rank : 266)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	292	Target Neighborhood Hits	432	Shared Neighborhood Hits	51
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ZN385_HUMAN
NC score	0.047788 (rank : 267)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	292	Target Neighborhood Hits	614	Shared Neighborhood Hits	63
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

IWS1_HUMAN
NC score	0.047515 (rank : 268)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	292	Target Neighborhood Hits	1241	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PELP1_MOUSE
NC score	0.047253 (rank : 269)	θ value	8.99809 (rank : 273)
Query Neighborhood Hits	292	Target Neighborhood Hits	709	Shared Neighborhood Hits	78
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

NUMBL_HUMAN
NC score	0.046145 (rank : 270)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	292	Target Neighborhood Hits	394	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

MTSS1_MOUSE
NC score	0.045017 (rank : 271)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	292	Target Neighborhood Hits	592	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

BAG3_MOUSE
NC score	0.044644 (rank : 272)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	292	Target Neighborhood Hits	513	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BSN_HUMAN
NC score	0.044160 (rank : 273)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	292	Target Neighborhood Hits	1537	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ANK2_HUMAN
NC score	0.044070 (rank : 274)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	292	Target Neighborhood Hits	1615	Shared Neighborhood Hits	107
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

WASF2_MOUSE
NC score	0.043596 (rank : 275)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	292	Target Neighborhood Hits	315	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

CECR2_HUMAN
NC score	0.043029 (rank : 276)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	292	Target Neighborhood Hits	543	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

MAP1A_HUMAN
NC score	0.042979 (rank : 277)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	292	Target Neighborhood Hits	1626	Shared Neighborhood Hits	96
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

PELP1_HUMAN
NC score	0.042617 (rank : 278)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	292	Target Neighborhood Hits	596	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

MLL2_HUMAN
NC score	0.041884 (rank : 279)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	292	Target Neighborhood Hits	1788	Shared Neighborhood Hits	113
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

WASF4_HUMAN
NC score	0.041560 (rank : 280)	θ value	8.99809 (rank : 291)
Query Neighborhood Hits	292	Target Neighborhood Hits	282	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

PSL1_HUMAN
NC score	0.041507 (rank : 281)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	292	Target Neighborhood Hits	650	Shared Neighborhood Hits	77
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

FGD1_MOUSE
NC score	0.040912 (rank : 282)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	292	Target Neighborhood Hits	387	Shared Neighborhood Hits	65
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

WASF1_HUMAN
NC score	0.040437 (rank : 283)	θ value	8.99809 (rank : 289)
Query Neighborhood Hits	292	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

GRIN1_HUMAN
NC score	0.040404 (rank : 284)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	292	Target Neighborhood Hits	681	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

RGS3_HUMAN
NC score	0.040338 (rank : 285)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	292	Target Neighborhood Hits	1375	Shared Neighborhood Hits	125
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CND2_HUMAN
NC score	0.039680 (rank : 286)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	292	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q15003, Q8TB87	Gene names	NCAPH, BRRN, BRRN1, CAPH, KIAA0074
Domain Architecture
Description	Condensin complex subunit 2 (Non-SMC condensin I complex subunit H) (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (XCAP-H homolog).

RANB9_HUMAN
NC score	0.039525 (rank : 287)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	292	Target Neighborhood Hits	179	Shared Neighborhood Hits	33
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

SPR1A_MOUSE
NC score	0.038950 (rank : 288)	θ value	6.88961 (rank : 241)
Query Neighborhood Hits	292	Target Neighborhood Hits	343	Shared Neighborhood Hits	61
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

P85B_HUMAN
NC score	0.038878 (rank : 289)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	292	Target Neighborhood Hits	543	Shared Neighborhood Hits	40
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PXK_HUMAN
NC score	0.038609 (rank : 290)	θ value	1.81305 (rank : 134)
Query Neighborhood Hits	292	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

CYLD_HUMAN
NC score	0.038179 (rank : 291)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	292	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQC7, O94934, Q7L3N6, Q96EH0, Q9NZX9	Gene names	CYLD, CYLD1, KIAA0849
Domain Architecture	No domain graphic available
Description	Probable ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.1.2.15) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) (Deubiquitinating enzyme CYLD).

WASF2_HUMAN
NC score	0.037966 (rank : 292)	θ value	8.99809 (rank : 290)
Query Neighborhood Hits	292	Target Neighborhood Hits	280	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

CEL_HUMAN
NC score	0.037318 (rank : 293)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	292	Target Neighborhood Hits	896	Shared Neighborhood Hits	89
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

JHD2A_MOUSE
NC score	0.037295 (rank : 294)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	292	Target Neighborhood Hits	123	Shared Neighborhood Hits	17
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

IF35_MOUSE
NC score	0.037263 (rank : 295)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	292	Target Neighborhood Hits	210	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

TB182_HUMAN
NC score	0.037023 (rank : 296)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	292	Target Neighborhood Hits	414	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

K0179_HUMAN
NC score	0.036528 (rank : 297)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	292	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

NUMBL_MOUSE
NC score	0.036339 (rank : 298)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	292	Target Neighborhood Hits	147	Shared Neighborhood Hits	27
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

3BP1_HUMAN
NC score	0.035978 (rank : 299)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	292	Target Neighborhood Hits	376	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

BMS1_HUMAN
NC score	0.035336 (rank : 300)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	292	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q14692, Q86XJ9	Gene names	BMS1L, KIAA0187
Domain Architecture
Description	Ribosome biogenesis protein BMS1 homolog.

K0310_HUMAN
NC score	0.034741 (rank : 301)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	292	Target Neighborhood Hits	420	Shared Neighborhood Hits	50
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

JIP3_HUMAN
NC score	0.034099 (rank : 302)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	292	Target Neighborhood Hits	1039	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

STABP_MOUSE
NC score	0.033760 (rank : 303)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	292	Target Neighborhood Hits	191	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

RP1L1_HUMAN
NC score	0.032939 (rank : 304)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	292	Target Neighborhood Hits	1072	Shared Neighborhood Hits	67
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

RAI1_HUMAN
NC score	0.032613 (rank : 305)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	292	Target Neighborhood Hits	360	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

JHD2A_HUMAN
NC score	0.032482 (rank : 306)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	292	Target Neighborhood Hits	118	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

EVC_HUMAN
NC score	0.032050 (rank : 307)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	292	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	P57679	Gene names	EVC
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein (DWF-1).

AFF2_MOUSE
NC score	0.032046 (rank : 308)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	292	Target Neighborhood Hits	225	Shared Neighborhood Hits	28
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

PDZD2_HUMAN
NC score	0.032012 (rank : 309)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	292	Target Neighborhood Hits	772	Shared Neighborhood Hits	67
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DPOD3_MOUSE
NC score	0.031998 (rank : 310)	θ value	3.0926 (rank : 161)
Query Neighborhood Hits	292	Target Neighborhood Hits	118	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EQ28	Gene names	Pold3
Domain Architecture	No domain graphic available
Description	DNA polymerase subunit delta 3 (DNA polymerase subunit delta p66).

CSKP_HUMAN
NC score	0.031594 (rank : 311)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	292	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
NC score	0.031289 (rank : 312)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	292	Target Neighborhood Hits	1027	Shared Neighborhood Hits	81
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CABL2_MOUSE
NC score	0.030892 (rank : 313)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	292	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

PRC1_MOUSE
NC score	0.030695 (rank : 314)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	292	Target Neighborhood Hits	382	Shared Neighborhood Hits	17
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

JADE2_MOUSE
NC score	0.030615 (rank : 315)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	292	Target Neighborhood Hits	560	Shared Neighborhood Hits	66
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

CD2L5_HUMAN
NC score	0.029071 (rank : 316)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	292	Target Neighborhood Hits	987	Shared Neighborhood Hits	54
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

ANTR1_MOUSE
NC score	0.028501 (rank : 317)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	292	Target Neighborhood Hits	143	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

CHRD_MOUSE
NC score	0.028101 (rank : 318)	θ value	0.62314 (rank : 73)
Query Neighborhood Hits	292	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

JPH1_MOUSE
NC score	0.027854 (rank : 319)	θ value	1.38821 (rank : 114)
Query Neighborhood Hits	292	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

SOX13_HUMAN
NC score	0.027336 (rank : 320)	θ value	1.81305 (rank : 136)
Query Neighborhood Hits	292	Target Neighborhood Hits	464	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SPR2D_MOUSE
NC score	0.027286 (rank : 321)	θ value	6.88961 (rank : 242)
Query Neighborhood Hits	292	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

PHC1_MOUSE
NC score	0.027114 (rank : 322)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	292	Target Neighborhood Hits	205	Shared Neighborhood Hits	19
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

PHLB1_HUMAN
NC score	0.026969 (rank : 323)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	292	Target Neighborhood Hits	1038	Shared Neighborhood Hits	74
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

STK10_HUMAN
NC score	0.026952 (rank : 324)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	292	Target Neighborhood Hits	1921	Shared Neighborhood Hits	80
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

RBM12_MOUSE
NC score	0.026947 (rank : 325)	θ value	8.99809 (rank : 277)
Query Neighborhood Hits	292	Target Neighborhood Hits	313	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

EHMT1_HUMAN
NC score	0.026840 (rank : 326)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	292	Target Neighborhood Hits	417	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

LIPA4_HUMAN
NC score	0.026330 (rank : 327)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	292	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

SC24B_HUMAN
NC score	0.026104 (rank : 328)	θ value	1.81305 (rank : 135)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	20
SwissProt Accessions	O95487	Gene names	SEC24B
Domain Architecture
Description	Protein transport protein Sec24B (SEC24-related protein B).

MARK3_MOUSE
NC score	0.025799 (rank : 329)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	292	Target Neighborhood Hits	919	Shared Neighborhood Hits	47
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MCSP_MOUSE
NC score	0.025724 (rank : 330)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	292	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

MARK3_HUMAN
NC score	0.024966 (rank : 331)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	292	Target Neighborhood Hits	893	Shared Neighborhood Hits	45
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PER1_HUMAN
NC score	0.024919 (rank : 332)	θ value	1.81305 (rank : 133)
Query Neighborhood Hits	292	Target Neighborhood Hits	215	Shared Neighborhood Hits	35
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

ANR25_HUMAN
NC score	0.024647 (rank : 333)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	292	Target Neighborhood Hits	350	Shared Neighborhood Hits	23
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

JHD2C_HUMAN
NC score	0.024415 (rank : 334)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	292	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

HCN2_HUMAN
NC score	0.024239 (rank : 335)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	292	Target Neighborhood Hits	369	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ZN598_HUMAN
NC score	0.023778 (rank : 336)	θ value	8.99809 (rank : 292)
Query Neighborhood Hits	292	Target Neighborhood Hits	339	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

FUBP1_HUMAN
NC score	0.023631 (rank : 337)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	292	Target Neighborhood Hits	136	Shared Neighborhood Hits	20
SwissProt Accessions	Q96AE4, Q12828	Gene names	FUBP1
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP) (DNA helicase V) (HDH V).

RAI14_HUMAN
NC score	0.023618 (rank : 338)	θ value	6.88961 (rank : 239)
Query Neighborhood Hits	292	Target Neighborhood Hits	1367	Shared Neighborhood Hits	40
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SOX13_MOUSE
NC score	0.023558 (rank : 339)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	292	Target Neighborhood Hits	495	Shared Neighborhood Hits	54
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

CD248_HUMAN
NC score	0.023533 (rank : 340)	θ value	3.0926 (rank : 160)
Query Neighborhood Hits	292	Target Neighborhood Hits	679	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MAST1_HUMAN
NC score	0.023531 (rank : 341)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	292	Target Neighborhood Hits	1146	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

DLGP4_HUMAN
NC score	0.023406 (rank : 342)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	292	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

FUBP1_MOUSE
NC score	0.023345 (rank : 343)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	292	Target Neighborhood Hits	144	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WJ8, Q8C0Y8	Gene names	Fubp1, D3Ertd330e
Domain Architecture
Description	Far upstream element-binding protein 1 (FUSE-binding protein 1) (FBP).

DNL1_MOUSE
NC score	0.022744 (rank : 344)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	292	Target Neighborhood Hits	110	Shared Neighborhood Hits	16
SwissProt Accessions	P37913	Gene names	Lig1, Lig-1
Domain Architecture
Description	DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1).

CLCN2_MOUSE
NC score	0.022667 (rank : 345)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	292	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

SPR2H_MOUSE
NC score	0.022584 (rank : 346)	θ value	8.99809 (rank : 283)
Query Neighborhood Hits	292	Target Neighborhood Hits	82	Shared Neighborhood Hits	11
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

GFAP_HUMAN
NC score	0.022500 (rank : 347)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	292	Target Neighborhood Hits	723	Shared Neighborhood Hits	21
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

MAST1_MOUSE
NC score	0.022463 (rank : 348)	θ value	1.38821 (rank : 116)
Query Neighborhood Hits	292	Target Neighborhood Hits	1123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KGP2_HUMAN
NC score	0.022370 (rank : 349)	θ value	1.38821 (rank : 115)
Query Neighborhood Hits	292	Target Neighborhood Hits	1023	Shared Neighborhood Hits	45
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CAC2D_MOUSE
NC score	0.022273 (rank : 350)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	292	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

USH2A_MOUSE
NC score	0.022268 (rank : 351)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	292	Target Neighborhood Hits	626	Shared Neighborhood Hits	33
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

IQEC3_MOUSE
NC score	0.022155 (rank : 352)	θ value	2.36792 (rank : 145)
Query Neighborhood Hits	292	Target Neighborhood Hits	274	Shared Neighborhood Hits	38
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

AP2A_MOUSE
NC score	0.021787 (rank : 353)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P34056, Q60740, Q60741, Q60742, Q60743, Q62067, Q62068, Q62069, Q91VX0, Q9CRY4	Gene names	Tfap2a, Ap2tf, Tcfap2a
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (Activator protein 2) (AP-2).

AP2A_HUMAN
NC score	0.021758 (rank : 354)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P05549, Q13777	Gene names	TFAP2A, AP2TF, TFAP2
Domain Architecture
Description	Transcription factor AP-2 alpha (AP2-alpha) (Activating enhancer- binding protein 2 alpha) (AP-2 transcription factor) (Activator protein 2) (AP-2).

SSRP1_HUMAN
NC score	0.021567 (rank : 355)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	292	Target Neighborhood Hits	187	Shared Neighborhood Hits	10
SwissProt Accessions	Q08945, Q5BJG8	Gene names	SSRP1, FACT80
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin- specific transcription elongation factor 80 kDa subunit) (Structure- specific recognition protein 1) (hSSRP1) (Recombination signal sequence recognition protein 1) (T160).

KGP2_MOUSE
NC score	0.021458 (rank : 356)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	292	Target Neighborhood Hits	1029	Shared Neighborhood Hits	44
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CO3A1_MOUSE
NC score	0.021440 (rank : 357)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	292	Target Neighborhood Hits	466	Shared Neighborhood Hits	51
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

MAST2_MOUSE
NC score	0.021040 (rank : 358)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	292	Target Neighborhood Hits	1110	Shared Neighborhood Hits	64
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

CFAH_MOUSE
NC score	0.020561 (rank : 359)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	292	Target Neighborhood Hits	112	Shared Neighborhood Hits	4
SwissProt Accessions	P06909	Gene names	Cfh, Hf1
Domain Architecture
Description	Complement factor H precursor (Protein beta-1-H).

CO5A2_HUMAN
NC score	0.019893 (rank : 360)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	292	Target Neighborhood Hits	760	Shared Neighborhood Hits	69
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

GFAP_MOUSE
NC score	0.018940 (rank : 361)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	292	Target Neighborhood Hits	725	Shared Neighborhood Hits	19
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

MYRIP_HUMAN
NC score	0.018768 (rank : 362)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	292	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ADA12_MOUSE
NC score	0.018575 (rank : 363)	θ value	0.163984 (rank : 46)
Query Neighborhood Hits	292	Target Neighborhood Hits	474	Shared Neighborhood Hits	49
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

SIN3A_MOUSE
NC score	0.018153 (rank : 364)	θ value	6.88961 (rank : 240)
Query Neighborhood Hits	292	Target Neighborhood Hits	169	Shared Neighborhood Hits	30
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

CK5P2_HUMAN
NC score	0.017613 (rank : 365)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	292	Target Neighborhood Hits	1433	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

HME1_MOUSE
NC score	0.017508 (rank : 366)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	292	Target Neighborhood Hits	397	Shared Neighborhood Hits	23
SwissProt Accessions	P09065	Gene names	En1, En-1
Domain Architecture
Description	Homeobox protein engrailed-1 (Mo-En-1).

RASF8_HUMAN
NC score	0.017458 (rank : 367)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	292	Target Neighborhood Hits	469	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

TLE4_HUMAN
NC score	0.017166 (rank : 368)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	292	Target Neighborhood Hits	477	Shared Neighborhood Hits	49
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

BAG4_HUMAN
NC score	0.016957 (rank : 369)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	292	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	O95429, O95818	Gene names	BAG4, SODD
Domain Architecture
Description	BAG family molecular chaperone regulator 4 (BCL2-associated athanogene 4) (BAG-4) (Silencer of death domains).

NFIA_MOUSE
NC score	0.016891 (rank : 370)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	292	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q02780, P70250, P70251, Q3UUZ2, Q61960, Q8VBT5, Q9R1G5	Gene names	Nfia
Domain Architecture
Description	Nuclear factor 1 A-type (Nuclear factor 1/A) (NF1-A) (NFI-A) (NF-I/A) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

TLE1_HUMAN
NC score	0.016838 (rank : 371)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	292	Target Neighborhood Hits	485	Shared Neighborhood Hits	41
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

DMRTD_MOUSE
NC score	0.016652 (rank : 372)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	292	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CGW9	Gene names	Dmrtc2, Dmrt7
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7).

TLE4_MOUSE
NC score	0.016505 (rank : 373)	θ value	8.99809 (rank : 284)
Query Neighborhood Hits	292	Target Neighborhood Hits	482	Shared Neighborhood Hits	52
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

CO8A1_HUMAN
NC score	0.016303 (rank : 374)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	292	Target Neighborhood Hits	288	Shared Neighborhood Hits	34
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

NFIA_HUMAN
NC score	0.016228 (rank : 375)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	292	Target Neighborhood Hits	65	Shared Neighborhood Hits	15
SwissProt Accessions	Q12857, Q9H3X9, Q9P2A9	Gene names	NFIA, KIAA1439
Domain Architecture
Description	Nuclear factor 1 A-type (Nuclear factor 1/A) (NF1-A) (NFI-A) (NF-I/A) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

TBCD8_MOUSE
NC score	0.016223 (rank : 376)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	292	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z1A9	Gene names	Tbc1d8, Hblp1, Vrp
Domain Architecture
Description	TBC1 domain family member 8 (Vascular Rab-GAP/TBC-containing protein) (BUB2-like protein 1).

IQGA2_HUMAN
NC score	0.015535 (rank : 377)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	292	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

NOTC3_HUMAN
NC score	0.015490 (rank : 378)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	292	Target Neighborhood Hits	1062	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ZDHC8_MOUSE
NC score	0.015412 (rank : 379)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	292	Target Neighborhood Hits	243	Shared Neighborhood Hits	23
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

NFIC_HUMAN
NC score	0.015015 (rank : 380)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	292	Target Neighborhood Hits	59	Shared Neighborhood Hits	14
SwissProt Accessions	P08651, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1	Gene names	NFIC, NFI
Domain Architecture
Description	Nuclear factor 1 C-type (Nuclear factor 1/C) (NF1-C) (NFI-C) (NF-I/C) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

FOG1_MOUSE
NC score	0.014607 (rank : 381)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	292	Target Neighborhood Hits	1237	Shared Neighborhood Hits	71
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

NAT6_MOUSE
NC score	0.014545 (rank : 382)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	292	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

NUFP1_MOUSE
NC score	0.014535 (rank : 383)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	292	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QXX8, Q9CV69	Gene names	Nufip1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

PIGQ_HUMAN
NC score	0.014073 (rank : 384)	θ value	8.99809 (rank : 275)
Query Neighborhood Hits	292	Target Neighborhood Hits	84	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BRB3, O14927, Q96G00, Q96S22, Q9UJH4	Gene names	PIGQ, GPI1
Domain Architecture
Description	Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q) (N-acetylglucosamyl transferase component GPI1).

HME1_HUMAN
NC score	0.013985 (rank : 385)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	292	Target Neighborhood Hits	384	Shared Neighborhood Hits	20
SwissProt Accessions	Q05925	Gene names	EN1
Domain Architecture
Description	Homeobox protein engrailed-1 (Hu-En-1).

NOTC3_MOUSE
NC score	0.013762 (rank : 386)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	292	Target Neighborhood Hits	975	Shared Neighborhood Hits	49
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

CO9A1_MOUSE
NC score	0.013478 (rank : 387)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	292	Target Neighborhood Hits	477	Shared Neighborhood Hits	51
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

PLXB1_HUMAN
NC score	0.012786 (rank : 388)	θ value	6.88961 (rank : 237)
Query Neighborhood Hits	292	Target Neighborhood Hits	360	Shared Neighborhood Hits	54
SwissProt Accessions	O43157, Q6NY20, Q9UIV7, Q9UJ92, Q9UJ93	Gene names	PLXNB1, KIAA0407, SEP
Domain Architecture	No domain graphic available
Description	Plexin-B1 precursor (Semaphorin receptor SEP).

ESX1L_HUMAN
NC score	0.012664 (rank : 389)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	292	Target Neighborhood Hits	498	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N693, Q7Z6K7	Gene names	ESX1L, ESX1R
Domain Architecture
Description	Extraembryonic, spermatogenesis, homeobox 1-like protein.

OCLN_MOUSE
NC score	0.012327 (rank : 390)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	292	Target Neighborhood Hits	121	Shared Neighborhood Hits	8
SwissProt Accessions	Q61146, Q544A7	Gene names	Ocln, Ocl
Domain Architecture
Description	Occludin.

MYCB2_HUMAN
NC score	0.012314 (rank : 391)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	292	Target Neighborhood Hits	390	Shared Neighborhood Hits	23
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NEMO_HUMAN
NC score	0.012193 (rank : 392)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	292	Target Neighborhood Hits	820	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

AIRE_MOUSE
NC score	0.012022 (rank : 393)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	292	Target Neighborhood Hits	196	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

MYCD_MOUSE
NC score	0.011431 (rank : 394)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	292	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

PHLPP_HUMAN
NC score	0.011343 (rank : 395)	θ value	6.88961 (rank : 236)
Query Neighborhood Hits	292	Target Neighborhood Hits	604	Shared Neighborhood Hits	42
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PRGR_MOUSE
NC score	0.011254 (rank : 396)	θ value	6.88961 (rank : 238)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	29
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

DDX50_MOUSE
NC score	0.010979 (rank : 397)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	292	Target Neighborhood Hits	137	Shared Neighborhood Hits	5
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

SFTA1_HUMAN
NC score	0.010721 (rank : 398)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	292	Target Neighborhood Hits	169	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWL2, P07714, Q5RIR5, Q5RIR7, Q6PIT0, Q8TC19	Gene names	SFTPA1, PSAP, SFTP1, SFTPA
Domain Architecture	No domain graphic available
Description	Pulmonary surfactant-associated protein A1 precursor (SP-A1) (SP-A) (PSP-A) (PSPA) (Alveolar proteinosis protein) (35 kDa pulmonary surfactant-associated protein).

TRPS1_MOUSE
NC score	0.010636 (rank : 399)	θ value	8.99809 (rank : 287)
Query Neighborhood Hits	292	Target Neighborhood Hits	609	Shared Neighborhood Hits	18
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

CBPZ_MOUSE
NC score	0.010549 (rank : 400)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	292	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R4V4	Gene names	Cpz
Domain Architecture	No domain graphic available
Description	Carboxypeptidase Z precursor (EC 3.4.17.-) (CPZ).

ZN516_MOUSE
NC score	0.010431 (rank : 401)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	292	Target Neighborhood Hits	1197	Shared Neighborhood Hits	61
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

PHF12_HUMAN
NC score	0.009751 (rank : 402)	θ value	8.99809 (rank : 274)
Query Neighborhood Hits	292	Target Neighborhood Hits	174	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QT6, Q6ZML2, Q9BV34, Q9H7U9, Q9P205	Gene names	PHF12, KIAA1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

SMCA2_HUMAN
NC score	0.009656 (rank : 403)	θ value	8.99809 (rank : 282)
Query Neighborhood Hits	292	Target Neighborhood Hits	503	Shared Neighborhood Hits	49
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

FAIM2_MOUSE
NC score	0.008899 (rank : 404)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	292	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K097, Q3TY22, Q8K1F6, Q9D6K4	Gene names	Faim2, Kiaa0950, Lfg
Domain Architecture
Description	Fas apoptotic inhibitory molecule 2 (Lifeguard protein).

DNM3A_MOUSE
NC score	0.008666 (rank : 405)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	292	Target Neighborhood Hits	91	Shared Neighborhood Hits	12
SwissProt Accessions	O88508, Q3UH24, Q8CJ60, Q922J0, Q9CSE1	Gene names	Dnmt3a
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA) (M.MmuIIIA).

DRD4_HUMAN
NC score	0.008401 (rank : 406)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	292	Target Neighborhood Hits	886	Shared Neighborhood Hits	21
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

SALL3_HUMAN
NC score	0.007841 (rank : 407)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	292	Target Neighborhood Hits	1066	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TRI47_HUMAN
NC score	0.007827 (rank : 408)	θ value	8.99809 (rank : 285)
Query Neighborhood Hits	292	Target Neighborhood Hits	286	Shared Neighborhood Hits	11
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

VSX1_HUMAN
NC score	0.006888 (rank : 409)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	292	Target Neighborhood Hits	344	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZR4, Q5TF40, Q5TF41, Q9HCU3, Q9NU27	Gene names	VSX1, RINX
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

TRI47_MOUSE
NC score	0.006789 (rank : 410)	θ value	8.99809 (rank : 286)
Query Neighborhood Hits	292	Target Neighborhood Hits	295	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

LRP10_HUMAN
NC score	0.006237 (rank : 411)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	292	Target Neighborhood Hits	197	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z4F1, O95882, Q86T02, Q8NCZ4, Q9HC42, Q9UG33	Gene names	LRP10
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

RREB1_HUMAN
NC score	0.005935 (rank : 412)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	292	Target Neighborhood Hits	879	Shared Neighborhood Hits	37
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

IRF6_HUMAN
NC score	0.005302 (rank : 413)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	292	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O14896	Gene names	IRF6
Domain Architecture
Description	Interferon regulatory factor 6 (IRF-6).

ANDR_MOUSE
NC score	0.004868 (rank : 414)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	292	Target Neighborhood Hits	133	Shared Neighborhood Hits	7
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

HLX1_HUMAN
NC score	0.002991 (rank : 415)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	292	Target Neighborhood Hits	370	Shared Neighborhood Hits	9
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

ATS20_MOUSE
NC score	0.002713 (rank : 416)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	292	Target Neighborhood Hits	225	Shared Neighborhood Hits	6
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ZN358_HUMAN
NC score	-0.001000 (rank : 417)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	292	Target Neighborhood Hits	840	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

IKAR_HUMAN
NC score	-0.001152 (rank : 418)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	292	Target Neighborhood Hits	726	Shared Neighborhood Hits	12
SwissProt Accessions	Q13422, O00598, Q8WVA3	Gene names	IKZF1, IK1, IKAROS, LYF1, ZNFN1A1
Domain Architecture	No domain graphic available
Description	DNA-binding protein Ikaros (IKAROS family zinc finger protein 1) (Lymphoid transcription factor LyF-1).

ZIC5_HUMAN
NC score	-0.001445 (rank : 419)	θ value	6.88961 (rank : 248)
Query Neighborhood Hits	292	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).