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Network neighborhood for query Sequence : CAC2D_MOUSE

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CAC2D_MOUSE
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CAC2D_HUMAN
θ value	0 (rank : 1)	NC score	0.997479 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	28
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

ITIH3_MOUSE
θ value	2.52405e-10 (rank : 3)	NC score	0.360114 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	34	Shared Neighborhood Hits	13
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH3_HUMAN
θ value	4.76016e-09 (rank : 4)	NC score	0.350310 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
θ value	5.44631e-05 (rank : 5)	NC score	0.312839 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH1_HUMAN
θ value	0.000121331 (rank : 6)	NC score	0.307037 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_HUMAN
θ value	0.000158464 (rank : 7)	NC score	0.305760 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
θ value	0.00020696 (rank : 8)	NC score	0.306030 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH4_HUMAN
θ value	0.000270298 (rank : 9)	NC score	0.311689 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

MATN1_HUMAN
θ value	0.00228821 (rank : 10)	NC score	0.147159 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	19
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

COCA1_HUMAN
θ value	0.00869519 (rank : 11)	NC score	0.098544 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	18
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COEA1_MOUSE
θ value	0.0113563 (rank : 12)	NC score	0.099513 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	402	Shared Neighborhood Hits	16
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

COCA1_MOUSE
θ value	0.0330416 (rank : 13)	NC score	0.094250 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	467	Shared Neighborhood Hits	16
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

MATN1_MOUSE
θ value	0.0330416 (rank : 14)	NC score	0.136775 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

MATN3_HUMAN
θ value	0.0563607 (rank : 15)	NC score	0.092268 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	268	Shared Neighborhood Hits	17
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

COEA1_HUMAN
θ value	0.21417 (rank : 16)	NC score	0.087458 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	427	Shared Neighborhood Hits	16
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COKA1_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.089588 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

SF04_HUMAN
θ value	0.47712 (rank : 18)	NC score	0.065432 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWZ8, O60378, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3	Gene names	SF4
Domain Architecture	No domain graphic available
Description	Splicing factor 4 (RNA-binding protein RBP).

MATN2_HUMAN
θ value	0.813845 (rank : 19)	NC score	0.063225 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	365	Shared Neighborhood Hits	19
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

MATN3_MOUSE
θ value	0.813845 (rank : 20)	NC score	0.083060 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	261	Shared Neighborhood Hits	18
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

SASH1_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.040463 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SF04_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.046655 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH02, Q8R094	Gene names	Sf4
Domain Architecture	No domain graphic available
Description	Splicing factor 4.

MATN2_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.060784 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	356	Shared Neighborhood Hits	19
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

MATN4_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.071679 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	287	Shared Neighborhood Hits	17
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

NDUBB_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.075081 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NX14, Q5JRR3, Q5JRR4, Q6IAB6, Q8WZ96, Q9BXX9	Gene names	NDUFB11
Domain Architecture	No domain graphic available
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ESSS subunit) (Complex I-ESSS) (CI-ESSS) (Neuronal protein 17.3) (p17.3) (Np17.3).

MATN4_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.074808 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	277	Shared Neighborhood Hits	19
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

FLNA_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.015010 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

NDUBB_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.062843 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	O09111	Gene names	Ndufb11, Np15
Domain Architecture	No domain graphic available
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ESSS subunit) (Complex I-ESSS) (CI-ESSS) (Neuronal protein 15.6) (p15.6) (Np15.6).

NUCL_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.013056 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

FLNA_MOUSE
θ value	5.27518 (rank : 30)	NC score	0.014551 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

ITAM_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.050240 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	P05555, Q8CA73	Gene names	Itgam
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (CD11b antigen).

LAMA2_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.004843 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	1198	Shared Neighborhood Hits	6
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

ASCC1_MOUSE
θ value	8.99809 (rank : 33)	NC score	0.023387 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D8Z1, Q3TAC2	Gene names	Ascc1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

CANT1_HUMAN
θ value	8.99809 (rank : 34)	NC score	0.022359 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVQ1, Q7Z2J7, Q8NG05, Q8NHP0, Q9BSD5	Gene names	CANT1, SHAPY
Domain Architecture	No domain graphic available
Description	Soluble calcium-activated nucleotidase 1 (EC 3.6.1.6) (SCAN-1) (Apyrase homolog) (Putative NF-kappa-B-activating protein 107) (Putative MAPK-activating protein PM09).

K1B16_MOUSE
θ value	8.99809 (rank : 35)	NC score	0.001998 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

MARK3_HUMAN
θ value	8.99809 (rank : 36)	NC score	-0.000705 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

NUCL_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.010109 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	425	Shared Neighborhood Hits	4
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

PARP4_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.069384 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

SASH1_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.022273 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	292	Shared Neighborhood Hits	4
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SC10A_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.003993 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCFD1_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.016459 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVM8, O60754, O94990, Q7Z529, Q9BZI3, Q9UNL3, Q9Y6A8	Gene names	SCFD1, KIAA0917, STXBP1L2
Domain Architecture	No domain graphic available
Description	Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1- like 2) (Sly1p).

SCFD1_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.016374 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BRF7, Q8BRZ2, Q8K179, Q9CXR8	Gene names	Scfd1, Stxbp1l2
Domain Architecture	No domain graphic available
Description	Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1- like 2).

CO6A3_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.053762 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	317	Shared Neighborhood Hits	14
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

COCH_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.074008 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	O43405	Gene names	COCH, COCH5B2
Domain Architecture
Description	Cochlin precursor (COCH-5B2).

COCH_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.073906 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q62507, Q3TAF5, Q9QWK6	Gene names	Coch
Domain Architecture
Description	Cochlin precursor (COCH-5B2).

LHR2A_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.054753 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

VITRN_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.074061 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UXI7, Q6P7T3, Q96DT1	Gene names	VIT
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

VITRN_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.074590 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHI5, Q3TZ47, Q8BQ41, Q8K047, Q9CYZ1	Gene names	Vit
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

Hits sorted by NC score

CAC2D_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CAC2D_HUMAN
NC score	0.997479 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	32	Shared Neighborhood Hits	28
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

ITIH3_MOUSE
NC score	0.360114 (rank : 3)	θ value	2.52405e-10 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	34	Shared Neighborhood Hits	13
SwissProt Accessions	Q61704	Gene names	Itih3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3).

ITIH3_HUMAN
NC score	0.350310 (rank : 4)	θ value	4.76016e-09 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q06033, Q99085	Gene names	ITIH3
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H3 precursor (ITI heavy chain H3) (Inter-alpha-inhibitor heavy chain 3) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH2_MOUSE
NC score	0.312839 (rank : 5)	θ value	5.44631e-05 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	14
SwissProt Accessions	Q61703	Gene names	Itih2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2).

ITIH4_HUMAN
NC score	0.311689 (rank : 6)	θ value	0.000270298 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	Q14624, Q15135, Q9P190, Q9UQ54	Gene names	ITIH4, IHRP, ITIHL1, PK120
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H4 precursor (ITI heavy chain H4) (Inter-alpha-inhibitor heavy chain 4) (Inter-alpha-trypsin inhibitor family heavy chain-related protein) (IHRP) (Plasma kallikrein sensitive glycoprotein 120) (PK-120) (GP120) [Contains: 70 kDa inter-alpha-trypsin inhibitor heavy chain H4; 35 kDa inter-alpha- trypsin inhibitor heavy chain H4].

ITIH1_HUMAN
NC score	0.307037 (rank : 7)	θ value	0.000121331 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	16
SwissProt Accessions	P19827, P78455, Q01746	Gene names	ITIH1, IGHEP1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).

ITIH1_MOUSE
NC score	0.306030 (rank : 8)	θ value	0.00020696 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q61702	Gene names	Itih1
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1).

ITIH2_HUMAN
NC score	0.305760 (rank : 9)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

MATN1_HUMAN
NC score	0.147159 (rank : 10)	θ value	0.00228821 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	191	Shared Neighborhood Hits	19
SwissProt Accessions	P21941	Gene names	MATN1, CMP, CRTM
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

MATN1_MOUSE
NC score	0.136775 (rank : 11)	θ value	0.0330416 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	186	Shared Neighborhood Hits	20
SwissProt Accessions	P51942	Gene names	Matn1, Cmp, Crtm
Domain Architecture
Description	Cartilage matrix protein precursor (Matrilin-1).

COEA1_MOUSE
NC score	0.099513 (rank : 12)	θ value	0.0113563 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	402	Shared Neighborhood Hits	16
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

COCA1_HUMAN
NC score	0.098544 (rank : 13)	θ value	0.00869519 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	18
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COCA1_MOUSE
NC score	0.094250 (rank : 14)	θ value	0.0330416 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	467	Shared Neighborhood Hits	16
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

MATN3_HUMAN
NC score	0.092268 (rank : 15)	θ value	0.0563607 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	268	Shared Neighborhood Hits	17
SwissProt Accessions	O15232	Gene names	MATN3
Domain Architecture
Description	Matrilin-3 precursor.

COKA1_HUMAN
NC score	0.089588 (rank : 16)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	403	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

COEA1_HUMAN
NC score	0.087458 (rank : 17)	θ value	0.21417 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	427	Shared Neighborhood Hits	16
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

MATN3_MOUSE
NC score	0.083060 (rank : 18)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	261	Shared Neighborhood Hits	18
SwissProt Accessions	O35701, Q9JHM0	Gene names	Matn3
Domain Architecture
Description	Matrilin-3 precursor.

NDUBB_HUMAN
NC score	0.075081 (rank : 19)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NX14, Q5JRR3, Q5JRR4, Q6IAB6, Q8WZ96, Q9BXX9	Gene names	NDUFB11
Domain Architecture	No domain graphic available
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ESSS subunit) (Complex I-ESSS) (CI-ESSS) (Neuronal protein 17.3) (p17.3) (Np17.3).

MATN4_MOUSE
NC score	0.074808 (rank : 20)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	277	Shared Neighborhood Hits	19
SwissProt Accessions	O89029, O89030, Q9QWS3	Gene names	Matn4
Domain Architecture
Description	Matrilin-4 precursor (MAT-4).

VITRN_MOUSE
NC score	0.074590 (rank : 21)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	42	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHI5, Q3TZ47, Q8BQ41, Q8K047, Q9CYZ1	Gene names	Vit
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

VITRN_HUMAN
NC score	0.074061 (rank : 22)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	42	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UXI7, Q6P7T3, Q96DT1	Gene names	VIT
Domain Architecture	No domain graphic available
Description	Vitrin precursor.

COCH_HUMAN
NC score	0.074008 (rank : 23)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	O43405	Gene names	COCH, COCH5B2
Domain Architecture
Description	Cochlin precursor (COCH-5B2).

COCH_MOUSE
NC score	0.073906 (rank : 24)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q62507, Q3TAF5, Q9QWK6	Gene names	Coch
Domain Architecture
Description	Cochlin precursor (COCH-5B2).

MATN4_HUMAN
NC score	0.071679 (rank : 25)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	287	Shared Neighborhood Hits	17
SwissProt Accessions	O95460, Q5QPU2, Q5QPU3, Q5QPU4, Q8N2M5, Q8N2M7, Q9H1F8, Q9H1F9	Gene names	MATN4
Domain Architecture
Description	Matrilin-4 precursor.

PARP4_HUMAN
NC score	0.069384 (rank : 26)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	93	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKK3, O75903, Q14682, Q9H1M6	Gene names	PARP4, ADPRTL1, KIAA0177, PARPL
Domain Architecture
Description	Poly [ADP-ribose] polymerase 4 (EC 2.4.2.30) (PARP-4) (Vault poly(ADP- ribose) polymerase) (VPARP) (193 kDa vault protein) (PARP- related/IalphaI-related H5/proline-rich) (PH5P).

SF04_HUMAN
NC score	0.065432 (rank : 27)	θ value	0.47712 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWZ8, O60378, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3	Gene names	SF4
Domain Architecture	No domain graphic available
Description	Splicing factor 4 (RNA-binding protein RBP).

MATN2_HUMAN
NC score	0.063225 (rank : 28)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	365	Shared Neighborhood Hits	19
SwissProt Accessions	O00339, Q6UWA5, Q7Z5X1, Q8NDE6, Q96FT5, Q9NSZ1	Gene names	MATN2
Domain Architecture
Description	Matrilin-2 precursor.

NDUBB_MOUSE
NC score	0.062843 (rank : 29)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	O09111	Gene names	Ndufb11, Np15
Domain Architecture	No domain graphic available
Description	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase ESSS subunit) (Complex I-ESSS) (CI-ESSS) (Neuronal protein 15.6) (p15.6) (Np15.6).

MATN2_MOUSE
NC score	0.060784 (rank : 30)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	356	Shared Neighborhood Hits	19
SwissProt Accessions	O08746	Gene names	Matn2
Domain Architecture
Description	Matrilin-2 precursor.

LHR2A_HUMAN
NC score	0.054753 (rank : 31)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	O00534, Q6UN19, Q6UN20, Q9BVF8	Gene names	LOH11CR2A, BCSC1
Domain Architecture
Description	Loss of heterozygosity 11 chromosomal region 2 gene A protein (Breast cancer suppressor candidate 1) (BCSC-1).

CO6A3_HUMAN
NC score	0.053762 (rank : 32)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	317	Shared Neighborhood Hits	14
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

ITAM_MOUSE
NC score	0.050240 (rank : 33)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	P05555, Q8CA73	Gene names	Itgam
Domain Architecture
Description	Integrin alpha-M precursor (Cell surface glycoprotein MAC-1 alpha subunit) (CR-3 alpha chain) (Leukocyte adhesion receptor MO1) (CD11b antigen).

SF04_MOUSE
NC score	0.046655 (rank : 34)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CH02, Q8R094	Gene names	Sf4
Domain Architecture	No domain graphic available
Description	Splicing factor 4.

SASH1_MOUSE
NC score	0.040463 (rank : 35)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ASCC1_MOUSE
NC score	0.023387 (rank : 36)	θ value	8.99809 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D8Z1, Q3TAC2	Gene names	Ascc1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

CANT1_HUMAN
NC score	0.022359 (rank : 37)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVQ1, Q7Z2J7, Q8NG05, Q8NHP0, Q9BSD5	Gene names	CANT1, SHAPY
Domain Architecture	No domain graphic available
Description	Soluble calcium-activated nucleotidase 1 (EC 3.6.1.6) (SCAN-1) (Apyrase homolog) (Putative NF-kappa-B-activating protein 107) (Putative MAPK-activating protein PM09).

SASH1_HUMAN
NC score	0.022273 (rank : 38)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	292	Shared Neighborhood Hits	4
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SCFD1_HUMAN
NC score	0.016459 (rank : 39)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WVM8, O60754, O94990, Q7Z529, Q9BZI3, Q9UNL3, Q9Y6A8	Gene names	SCFD1, KIAA0917, STXBP1L2
Domain Architecture	No domain graphic available
Description	Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1- like 2) (Sly1p).

SCFD1_MOUSE
NC score	0.016374 (rank : 40)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BRF7, Q8BRZ2, Q8K179, Q9CXR8	Gene names	Scfd1, Stxbp1l2
Domain Architecture	No domain graphic available
Description	Sec1 family domain-containing protein 1 (Syntaxin-binding protein 1- like 2).

FLNA_HUMAN
NC score	0.015010 (rank : 41)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNA_MOUSE
NC score	0.014551 (rank : 42)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

NUCL_HUMAN
NC score	0.013056 (rank : 43)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

NUCL_MOUSE
NC score	0.010109 (rank : 44)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	425	Shared Neighborhood Hits	4
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

LAMA2_MOUSE
NC score	0.004843 (rank : 45)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	1198	Shared Neighborhood Hits	6
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

SC10A_HUMAN
NC score	0.003993 (rank : 46)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

K1B16_MOUSE
NC score	0.001998 (rank : 47)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P04071	Gene names	Klk1b16, Klk-16, Klk16
Domain Architecture
Description	Kallikrein 1-related peptidase b16 precursor (EC 3.4.21.54) (Gamma- renin, submandibular gland) (mGK-16).

MARK3_HUMAN
NC score	-0.000705 (rank : 48)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	893	Shared Neighborhood Hits	4
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).