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Network neighborhood for query Sequence : SAMN1_MOUSE

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SAMN1_MOUSE
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SAMN1_MOUSE
θ value	4.12933e-154 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SAMN1_HUMAN
θ value	4.00889e-141 (rank : 2)	NC score	0.989030 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SLY_HUMAN
θ value	1.50663e-63 (rank : 3)	NC score	0.940263 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	2.40537e-61 (rank : 4)	NC score	0.929349 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SASH1_HUMAN
θ value	5.03882e-43 (rank : 5)	NC score	0.816983 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	6.58091e-43 (rank : 6)	NC score	0.812510 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ANKS1_MOUSE
θ value	2.21117e-06 (rank : 7)	NC score	0.152816 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANKS1_HUMAN
θ value	6.43352e-06 (rank : 8)	NC score	0.146150 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	438	Shared Neighborhood Hits	16
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

MYO1E_HUMAN
θ value	0.00134147 (rank : 9)	NC score	0.092303 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	44
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

CD2AP_HUMAN
θ value	0.00175202 (rank : 10)	NC score	0.202186 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ARHG6_HUMAN
θ value	0.0736092 (rank : 11)	NC score	0.149139 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CRK_MOUSE
θ value	0.0736092 (rank : 12)	NC score	0.184662 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CSKI1_HUMAN
θ value	0.0961366 (rank : 13)	NC score	0.087430 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	997	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.0961366 (rank : 14)	NC score	0.088144 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	1031	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EPHA2_MOUSE
θ value	0.0961366 (rank : 15)	NC score	0.023226 (rank : 103)
Query Neighborhood Hits	69	Target Neighborhood Hits	1020	Shared Neighborhood Hits	18
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

CRKL_HUMAN
θ value	0.125558 (rank : 16)	NC score	0.170708 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	313	Shared Neighborhood Hits	46
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.125558 (rank : 17)	NC score	0.170378 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	0.163984 (rank : 18)	NC score	0.177448 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	46
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

VAV_HUMAN
θ value	0.163984 (rank : 19)	NC score	0.114782 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

EPHA2_HUMAN
θ value	0.21417 (rank : 20)	NC score	0.021425 (rank : 105)
Query Neighborhood Hits	69	Target Neighborhood Hits	1021	Shared Neighborhood Hits	19
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

M3K9_HUMAN
θ value	0.21417 (rank : 21)	NC score	0.033167 (rank : 98)
Query Neighborhood Hits	69	Target Neighborhood Hits	1123	Shared Neighborhood Hits	47
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

VAV_MOUSE
θ value	0.21417 (rank : 22)	NC score	0.115202 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	430	Shared Neighborhood Hits	42
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG6_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.143223 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_MOUSE
θ value	0.365318 (rank : 24)	NC score	0.136783 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP2_MOUSE
θ value	0.365318 (rank : 25)	NC score	0.108628 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MYO1F_HUMAN
θ value	0.365318 (rank : 26)	NC score	0.074828 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	275	Shared Neighborhood Hits	46
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

ARHG7_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.140063 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	347	Shared Neighborhood Hits	44
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GRAP2_HUMAN
θ value	0.813845 (rank : 28)	NC score	0.100530 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	304	Shared Neighborhood Hits	44
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_HUMAN
θ value	0.813845 (rank : 29)	NC score	0.127818 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CP7A1_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.016412 (rank : 110)
Query Neighborhood Hits	69	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	P22680, P78454, Q7KZ19	Gene names	CYP7A1, CYP7
Domain Architecture
Description	Cytochrome P450 7A1 (Cholesterol 7-alpha-monooxygenase) (CYPVII) (EC 1.14.13.17) (Cholesterol 7-alpha-hydroxylase).

ITSN1_MOUSE
θ value	1.06291 (rank : 31)	NC score	0.068955 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	1669	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ZFYV9_HUMAN
θ value	1.06291 (rank : 32)	NC score	0.022419 (rank : 104)
Query Neighborhood Hits	69	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

AHTF1_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.028318 (rank : 101)
Query Neighborhood Hits	69	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

ITSN1_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.077646 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	1757	Shared Neighborhood Hits	50
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

K0146_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.030044 (rank : 100)
Query Neighborhood Hits	69	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q14159, Q96BI5	Gene names	KIAA0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

RPGF6_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.017355 (rank : 108)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SH3K1_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.165163 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	1.38821 (rank : 38)	NC score	0.163570 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

DLGP4_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.025510 (rank : 102)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

SH3G3_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.112653 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	236	Shared Neighborhood Hits	42
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VAV3_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.100099 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CEND1_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.040328 (rank : 97)
Query Neighborhood Hits	69	Target Neighborhood Hits	284	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SH3G1_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.083353 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ADEC1_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.011637 (rank : 113)
Query Neighborhood Hits	69	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADEC1_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.012490 (rank : 112)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ERC2_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.009045 (rank : 115)
Query Neighborhood Hits	69	Target Neighborhood Hits	1156	Shared Neighborhood Hits	11
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

GON4L_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.017143 (rank : 109)
Query Neighborhood Hits	69	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

GRAP_MOUSE
θ value	3.0926 (rank : 48)	NC score	0.116543 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	309	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1F_MOUSE
θ value	3.0926 (rank : 49)	NC score	0.059595 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	42
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

STAC_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.108259 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	276	Shared Neighborhood Hits	46
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.108347 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.081675 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

TOP2B_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.014726 (rank : 111)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

VAV3_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.097776 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ZN192_HUMAN
θ value	3.0926 (rank : 55)	NC score	0.000419 (rank : 118)
Query Neighborhood Hits	69	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

ERC2_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.008769 (rank : 116)
Query Neighborhood Hits	69	Target Neighborhood Hits	1166	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

NCK2_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.109333 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

APC_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.020497 (rank : 106)
Query Neighborhood Hits	69	Target Neighborhood Hits	603	Shared Neighborhood Hits	8
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

ARHG4_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.062897 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	185	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SUHW4_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.002674 (rank : 117)
Query Neighborhood Hits	69	Target Neighborhood Hits	860	Shared Neighborhood Hits	4
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

CEND1_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.031061 (rank : 99)
Query Neighborhood Hits	69	Target Neighborhood Hits	260	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CSKI2_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.072449 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	747	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA5_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.017710 (rank : 107)
Query Neighborhood Hits	69	Target Neighborhood Hits	1009	Shared Neighborhood Hits	16
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

SH3G2_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.100611 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.080020 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	222	Shared Neighborhood Hits	38
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRBS1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.100744 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CSKI2_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.075298 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	812	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

LAMA3_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.010666 (rank : 114)
Query Neighborhood Hits	69	Target Neighborhood Hits	859	Shared Neighborhood Hits	12
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

VINEX_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.097206 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.053062 (rank : 92)
Query Neighborhood Hits	69	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.055468 (rank : 87)
Query Neighborhood Hits	69	Target Neighborhood Hits	246	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.078959 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.081100 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.054377 (rank : 90)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG4_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.062075 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.057001 (rank : 83)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.056292 (rank : 85)
Query Neighborhood Hits	69	Target Neighborhood Hits	234	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CD2AP_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.153004 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	336	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CT032_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.054846 (rank : 89)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.053687 (rank : 91)
Query Neighborhood Hits	69	Target Neighborhood Hits	244	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.052694 (rank : 93)
Query Neighborhood Hits	69	Target Neighborhood Hits	306	Shared Neighborhood Hits	36
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DNMBP_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.064379 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.064481 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	435	Shared Neighborhood Hits	36
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRB2_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.076907 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.076762 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	38
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCLS1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.066967 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.060966 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.065826 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	1173	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.062011 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	1371	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCF1_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.070481 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.069647 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.077463 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.061374 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.063397 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	36
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.078923 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NPHP1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.052512 (rank : 95)
Query Neighborhood Hits	69	Target Neighborhood Hits	288	Shared Neighborhood Hits	35
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.070334 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	267	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.080462 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	466	Shared Neighborhood Hits	45
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.081896 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	467	Shared Neighborhood Hits	45
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.052540 (rank : 94)
Query Neighborhood Hits	69	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.052096 (rank : 96)
Query Neighborhood Hits	69	Target Neighborhood Hits	382	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.054987 (rank : 88)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.055627 (rank : 86)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PPIP1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.057484 (rank : 82)
Query Neighborhood Hits	69	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.056707 (rank : 84)
Query Neighborhood Hits	69	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G1_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.078347 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.086729 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	324	Shared Neighborhood Hits	40
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SRBS1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.089481 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	409	Shared Neighborhood Hits	43
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.058450 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.057619 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.063101 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.063870 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.065759 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.062855 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.064148 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.084123 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	40
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.082895 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VINEX_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.093246 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

SAMN1_MOUSE
NC score	0.999962 (rank : 1)	θ value	4.12933e-154 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SAMN1_HUMAN
NC score	0.989030 (rank : 2)	θ value	4.00889e-141 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SLY_HUMAN
NC score	0.940263 (rank : 3)	θ value	1.50663e-63 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
NC score	0.929349 (rank : 4)	θ value	2.40537e-61 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	108	Shared Neighborhood Hits	49
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SASH1_HUMAN
NC score	0.816983 (rank : 5)	θ value	5.03882e-43 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
NC score	0.812510 (rank : 6)	θ value	6.58091e-43 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CD2AP_HUMAN
NC score	0.202186 (rank : 7)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	315	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CRK_MOUSE
NC score	0.184662 (rank : 8)	θ value	0.0736092 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	45
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.177448 (rank : 9)	θ value	0.163984 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	46
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_HUMAN
NC score	0.170708 (rank : 10)	θ value	0.125558 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	313	Shared Neighborhood Hits	46
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.170378 (rank : 11)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3K1_HUMAN
NC score	0.165163 (rank : 12)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	341	Shared Neighborhood Hits	48
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.163570 (rank : 13)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	332	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.153004 (rank : 14)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	336	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ANKS1_MOUSE
NC score	0.152816 (rank : 15)	θ value	2.21117e-06 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ARHG6_HUMAN
NC score	0.149139 (rank : 16)	θ value	0.0736092 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ANKS1_HUMAN
NC score	0.146150 (rank : 17)	θ value	6.43352e-06 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	438	Shared Neighborhood Hits	16
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ARHG6_MOUSE
NC score	0.143223 (rank : 18)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	394	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
NC score	0.140063 (rank : 19)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	347	Shared Neighborhood Hits	44
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
NC score	0.136783 (rank : 20)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	396	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_HUMAN
NC score	0.127818 (rank : 21)	θ value	0.813845 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.116543 (rank : 22)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	309	Shared Neighborhood Hits	46
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

VAV_MOUSE
NC score	0.115202 (rank : 23)	θ value	0.21417 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	430	Shared Neighborhood Hits	42
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.114782 (rank : 24)	θ value	0.163984 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SH3G3_MOUSE
NC score	0.112653 (rank : 25)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	236	Shared Neighborhood Hits	42
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCK2_HUMAN
NC score	0.109333 (rank : 26)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRAP2_MOUSE
NC score	0.108628 (rank : 27)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC_MOUSE
NC score	0.108347 (rank : 28)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	268	Shared Neighborhood Hits	46
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_HUMAN
NC score	0.108259 (rank : 29)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	276	Shared Neighborhood Hits	46
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.100744 (rank : 30)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SH3G2_MOUSE
NC score	0.100611 (rank : 31)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	319	Shared Neighborhood Hits	44
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

GRAP2_HUMAN
NC score	0.100530 (rank : 32)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	304	Shared Neighborhood Hits	44
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

VAV3_HUMAN
NC score	0.100099 (rank : 33)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.097776 (rank : 34)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VINEX_HUMAN
NC score	0.097206 (rank : 35)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	270	Shared Neighborhood Hits	40
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.093246 (rank : 36)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	69	Target Neighborhood Hits	286	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

MYO1E_HUMAN
NC score	0.092303 (rank : 37)	θ value	0.00134147 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	44
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SRBS1_MOUSE
NC score	0.089481 (rank : 38)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	69	Target Neighborhood Hits	409	Shared Neighborhood Hits	43
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CSKI1_MOUSE
NC score	0.088144 (rank : 39)	θ value	0.0961366 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	1031	Shared Neighborhood Hits	39
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.087430 (rank : 40)	θ value	0.0961366 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	997	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SH3G2_HUMAN
NC score	0.086729 (rank : 41)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	69	Target Neighborhood Hits	324	Shared Neighborhood Hits	40
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV2_HUMAN
NC score	0.084123 (rank : 42)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	40
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SH3G1_MOUSE
NC score	0.083353 (rank : 43)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

VAV2_MOUSE
NC score	0.082895 (rank : 44)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	69	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

OSTF1_MOUSE
NC score	0.081896 (rank : 45)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	69	Target Neighborhood Hits	467	Shared Neighborhood Hits	45
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

STAM1_HUMAN
NC score	0.081675 (rank : 46)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	271	Shared Neighborhood Hits	42
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ABI2_MOUSE
NC score	0.081100 (rank : 47)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

OSTF1_HUMAN
NC score	0.080462 (rank : 48)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	69	Target Neighborhood Hits	466	Shared Neighborhood Hits	45
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G3_HUMAN
NC score	0.080020 (rank : 49)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	222	Shared Neighborhood Hits	38
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ABI2_HUMAN
NC score	0.078959 (rank : 50)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCK1_HUMAN
NC score	0.078923 (rank : 51)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	39
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3G1_HUMAN
NC score	0.078347 (rank : 52)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	40
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ITSN1_HUMAN
NC score	0.077646 (rank : 53)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	1757	Shared Neighborhood Hits	50
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NCF2_HUMAN
NC score	0.077463 (rank : 54)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	69	Target Neighborhood Hits	229	Shared Neighborhood Hits	37
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

GRB2_HUMAN
NC score	0.076907 (rank : 55)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	38
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.076762 (rank : 56)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	38
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CSKI2_MOUSE
NC score	0.075298 (rank : 57)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	812	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

MYO1F_HUMAN
NC score	0.074828 (rank : 58)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	275	Shared Neighborhood Hits	46
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

CSKI2_HUMAN
NC score	0.072449 (rank : 59)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	747	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NCF1_HUMAN
NC score	0.070481 (rank : 60)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_MOUSE
NC score	0.070334 (rank : 61)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	69	Target Neighborhood Hits	267	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NCF1_MOUSE
NC score	0.069647 (rank : 62)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ITSN1_MOUSE
NC score	0.068955 (rank : 63)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	1669	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

HCLS1_HUMAN
NC score	0.066967 (rank : 64)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	69	Target Neighborhood Hits	358	Shared Neighborhood Hits	38
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ITSN2_HUMAN
NC score	0.065826 (rank : 65)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	69	Target Neighborhood Hits	1173	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAM1_MOUSE
NC score	0.065759 (rank : 66)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	69	Target Neighborhood Hits	273	Shared Neighborhood Hits	40
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

DNMBP_MOUSE
NC score	0.064481 (rank : 67)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	69	Target Neighborhood Hits	435	Shared Neighborhood Hits	36
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_HUMAN
NC score	0.064379 (rank : 68)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	69	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM2_MOUSE
NC score	0.064148 (rank : 69)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	69	Target Neighborhood Hits	285	Shared Neighborhood Hits	43
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAC3_MOUSE
NC score	0.063870 (rank : 70)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	69	Target Neighborhood Hits	232	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCF4_MOUSE
NC score	0.063397 (rank : 71)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	36
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC3_HUMAN
NC score	0.063101 (rank : 72)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	69	Target Neighborhood Hits	228	Shared Neighborhood Hits	37
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG4_MOUSE
NC score	0.062897 (rank : 73)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	185	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

STAM2_HUMAN
NC score	0.062855 (rank : 74)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	69	Target Neighborhood Hits	288	Shared Neighborhood Hits	40
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG4_HUMAN
NC score	0.062075 (rank : 75)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	242	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN2_MOUSE
NC score	0.062011 (rank : 76)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	69	Target Neighborhood Hits	1371	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCF4_HUMAN
NC score	0.061374 (rank : 77)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	69	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

HCLS1_MOUSE
NC score	0.060966 (rank : 78)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	69	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MYO1F_MOUSE
NC score	0.059595 (rank : 79)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	42
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SRC8_HUMAN
NC score	0.058450 (rank : 80)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	69	Target Neighborhood Hits	269	Shared Neighborhood Hits	36
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.057619 (rank : 81)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	69	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PPIP1_HUMAN
NC score	0.057484 (rank : 82)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	69	Target Neighborhood Hits	389	Shared Neighborhood Hits	35
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ARHG9_HUMAN
NC score	0.057001 (rank : 83)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	36
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

PPIP1_MOUSE
NC score	0.056707 (rank : 84)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	69	Target Neighborhood Hits	377	Shared Neighborhood Hits	35
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ARHG9_MOUSE
NC score	0.056292 (rank : 85)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	234	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PLCG1_MOUSE
NC score	0.055627 (rank : 86)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	35
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ABI1_MOUSE
NC score	0.055468 (rank : 87)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	246	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PLCG1_HUMAN
NC score	0.054987 (rank : 88)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	34
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CT032_HUMAN
NC score	0.054846 (rank : 89)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ABI3_HUMAN
NC score	0.054377 (rank : 90)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	37
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DBNL_HUMAN
NC score	0.053687 (rank : 91)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	244	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ABI1_HUMAN
NC score	0.053062 (rank : 92)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	257	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

DBNL_MOUSE
NC score	0.052694 (rank : 93)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	306	Shared Neighborhood Hits	36
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PACN2_HUMAN
NC score	0.052540 (rank : 94)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	69	Target Neighborhood Hits	339	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NPHP1_HUMAN
NC score	0.052512 (rank : 95)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	69	Target Neighborhood Hits	288	Shared Neighborhood Hits	35
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN2_MOUSE
NC score	0.052096 (rank : 96)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	69	Target Neighborhood Hits	382	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

CEND1_HUMAN
NC score	0.040328 (rank : 97)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	284	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

M3K9_HUMAN
NC score	0.033167 (rank : 98)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	1123	Shared Neighborhood Hits	47
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CEND1_MOUSE
NC score	0.031061 (rank : 99)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	260	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

K0146_HUMAN
NC score	0.030044 (rank : 100)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q14159, Q96BI5	Gene names	KIAA0146
Domain Architecture	No domain graphic available
Description	Protein KIAA0146.

AHTF1_MOUSE
NC score	0.028318 (rank : 101)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	176	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CJF7, Q8BVJ5, Q8VD55	Gene names	Ahctf1, Elys
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

DLGP4_HUMAN
NC score	0.025510 (rank : 102)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2H0, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7	Gene names	DLGAP4, DAP4, KIAA0964
Domain Architecture
Description	Disks large-associated protein 4 (DAP-4) (SAP90/PSD-95-associated protein 4) (SAPAP4) (PSD-95/SAP90-binding protein 4).

EPHA2_MOUSE
NC score	0.023226 (rank : 103)	θ value	0.0961366 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	1020	Shared Neighborhood Hits	18
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

ZFYV9_HUMAN
NC score	0.022419 (rank : 104)	θ value	1.06291 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

EPHA2_HUMAN
NC score	0.021425 (rank : 105)	θ value	0.21417 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	1021	Shared Neighborhood Hits	19
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

APC_HUMAN
NC score	0.020497 (rank : 106)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	603	Shared Neighborhood Hits	8
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

EPHA5_HUMAN
NC score	0.017710 (rank : 107)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	1009	Shared Neighborhood Hits	16
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

RPGF6_HUMAN
NC score	0.017355 (rank : 108)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

GON4L_HUMAN
NC score	0.017143 (rank : 109)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	555	Shared Neighborhood Hits	7
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

CP7A1_HUMAN
NC score	0.016412 (rank : 110)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	P22680, P78454, Q7KZ19	Gene names	CYP7A1, CYP7
Domain Architecture
Description	Cytochrome P450 7A1 (Cholesterol 7-alpha-monooxygenase) (CYPVII) (EC 1.14.13.17) (Cholesterol 7-alpha-hydroxylase).

TOP2B_HUMAN
NC score	0.014726 (rank : 111)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	Q02880, Q13600, Q9UMG8, Q9UQP8	Gene names	TOP2B
Domain Architecture
Description	DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme).

ADEC1_MOUSE
NC score	0.012490 (rank : 112)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADEC1_HUMAN
NC score	0.011637 (rank : 113)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	80	Shared Neighborhood Hits	3
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

LAMA3_MOUSE
NC score	0.010666 (rank : 114)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	859	Shared Neighborhood Hits	12
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

ERC2_HUMAN
NC score	0.009045 (rank : 115)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	1156	Shared Neighborhood Hits	11
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
NC score	0.008769 (rank : 116)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	1166	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

SUHW4_HUMAN
NC score	0.002674 (rank : 117)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	860	Shared Neighborhood Hits	4
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

ZN192_HUMAN
NC score	0.000419 (rank : 118)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	789	Shared Neighborhood Hits	5
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).