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Network neighborhood for query Sequence : HCLS1_HUMAN

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HCLS1_HUMAN
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HCLS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	358	Target Neighborhood Hits	358	Shared Neighborhood Hits	358
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	0 (rank : 2)	NC score	0.965799 (rank : 2)
Query Neighborhood Hits	358	Target Neighborhood Hits	329	Shared Neighborhood Hits	221
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_MOUSE
θ value	1.87955e-106 (rank : 3)	NC score	0.934019 (rank : 3)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	177
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
θ value	4.49445e-92 (rank : 4)	NC score	0.930814 (rank : 4)
Query Neighborhood Hits	358	Target Neighborhood Hits	269	Shared Neighborhood Hits	177
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DBNL_HUMAN
θ value	1.058e-16 (rank : 5)	NC score	0.694494 (rank : 5)
Query Neighborhood Hits	358	Target Neighborhood Hits	244	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	2.60593e-15 (rank : 6)	NC score	0.687107 (rank : 6)
Query Neighborhood Hits	358	Target Neighborhood Hits	306	Shared Neighborhood Hits	158
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ITSN1_MOUSE
θ value	9.59137e-10 (rank : 7)	NC score	0.404046 (rank : 89)
Query Neighborhood Hits	358	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
θ value	2.79066e-09 (rank : 8)	NC score	0.404291 (rank : 88)
Query Neighborhood Hits	358	Target Neighborhood Hits	1757	Shared Neighborhood Hits	236
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3G2_HUMAN
θ value	3.64472e-09 (rank : 9)	NC score	0.616356 (rank : 14)
Query Neighborhood Hits	358	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

MYO1F_HUMAN
θ value	1.06045e-08 (rank : 10)	NC score	0.284631 (rank : 119)
Query Neighborhood Hits	358	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	1.38499e-08 (rank : 11)	NC score	0.283197 (rank : 120)
Query Neighborhood Hits	358	Target Neighborhood Hits	262	Shared Neighborhood Hits	168
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PACN2_HUMAN
θ value	2.36244e-08 (rank : 12)	NC score	0.588277 (rank : 23)
Query Neighborhood Hits	358	Target Neighborhood Hits	339	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	4.0297e-08 (rank : 13)	NC score	0.587919 (rank : 24)
Query Neighborhood Hits	358	Target Neighborhood Hits	382	Shared Neighborhood Hits	168
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3K1_MOUSE
θ value	5.26297e-08 (rank : 14)	NC score	0.656580 (rank : 7)
Query Neighborhood Hits	358	Target Neighborhood Hits	332	Shared Neighborhood Hits	171
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3G2_MOUSE
θ value	6.87365e-08 (rank : 15)	NC score	0.607874 (rank : 19)
Query Neighborhood Hits	358	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_HUMAN
θ value	6.87365e-08 (rank : 16)	NC score	0.654548 (rank : 8)
Query Neighborhood Hits	358	Target Neighborhood Hits	341	Shared Neighborhood Hits	167
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

PACN1_MOUSE
θ value	8.97725e-08 (rank : 17)	NC score	0.578538 (rank : 27)
Query Neighborhood Hits	358	Target Neighborhood Hits	283	Shared Neighborhood Hits	165
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CD2AP_MOUSE
θ value	1.53129e-07 (rank : 18)	NC score	0.651735 (rank : 9)
Query Neighborhood Hits	358	Target Neighborhood Hits	336	Shared Neighborhood Hits	185
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ITSN2_HUMAN
θ value	1.53129e-07 (rank : 19)	NC score	0.420197 (rank : 81)
Query Neighborhood Hits	358	Target Neighborhood Hits	1173	Shared Neighborhood Hits	193
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MYO1E_HUMAN
θ value	1.53129e-07 (rank : 20)	NC score	0.274976 (rank : 121)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	168
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PACN1_HUMAN
θ value	1.53129e-07 (rank : 21)	NC score	0.573202 (rank : 30)
Query Neighborhood Hits	358	Target Neighborhood Hits	320	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3G1_MOUSE
θ value	1.99992e-07 (rank : 22)	NC score	0.589732 (rank : 22)
Query Neighborhood Hits	358	Target Neighborhood Hits	291	Shared Neighborhood Hits	166
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_HUMAN
θ value	1.99992e-07 (rank : 23)	NC score	0.606602 (rank : 20)
Query Neighborhood Hits	358	Target Neighborhood Hits	222	Shared Neighborhood Hits	158
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ITSN2_MOUSE
θ value	2.61198e-07 (rank : 24)	NC score	0.400861 (rank : 90)
Query Neighborhood Hits	358	Target Neighborhood Hits	1371	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

GRAP2_HUMAN
θ value	4.45536e-07 (rank : 25)	NC score	0.560993 (rank : 36)
Query Neighborhood Hits	358	Target Neighborhood Hits	304	Shared Neighborhood Hits	176
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	5.81887e-07 (rank : 26)	NC score	0.565116 (rank : 34)
Query Neighborhood Hits	358	Target Neighborhood Hits	297	Shared Neighborhood Hits	176
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G3_MOUSE
θ value	5.81887e-07 (rank : 27)	NC score	0.615291 (rank : 15)
Query Neighborhood Hits	358	Target Neighborhood Hits	236	Shared Neighborhood Hits	162
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

OSTF1_MOUSE
θ value	7.59969e-07 (rank : 28)	NC score	0.474392 (rank : 65)
Query Neighborhood Hits	358	Target Neighborhood Hits	467	Shared Neighborhood Hits	175
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SH3G1_HUMAN
θ value	7.59969e-07 (rank : 29)	NC score	0.585316 (rank : 25)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ABI1_MOUSE
θ value	1.69304e-06 (rank : 30)	NC score	0.610777 (rank : 16)
Query Neighborhood Hits	358	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	1.69304e-06 (rank : 31)	NC score	0.620595 (rank : 12)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	1.69304e-06 (rank : 32)	NC score	0.623518 (rank : 11)
Query Neighborhood Hits	358	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CD2AP_HUMAN
θ value	1.69304e-06 (rank : 33)	NC score	0.638004 (rank : 10)
Query Neighborhood Hits	358	Target Neighborhood Hits	315	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ABI1_HUMAN
θ value	2.21117e-06 (rank : 34)	NC score	0.592114 (rank : 21)
Query Neighborhood Hits	358	Target Neighborhood Hits	257	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRB2_HUMAN
θ value	2.21117e-06 (rank : 35)	NC score	0.555754 (rank : 37)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	2.21117e-06 (rank : 36)	NC score	0.555468 (rank : 38)
Query Neighborhood Hits	358	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC_HUMAN
θ value	2.21117e-06 (rank : 37)	NC score	0.576812 (rank : 28)
Query Neighborhood Hits	358	Target Neighborhood Hits	276	Shared Neighborhood Hits	162
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

NCK2_HUMAN
θ value	2.88788e-06 (rank : 38)	NC score	0.536774 (rank : 44)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PACN3_MOUSE
θ value	2.88788e-06 (rank : 39)	NC score	0.543971 (rank : 41)
Query Neighborhood Hits	358	Target Neighborhood Hits	380	Shared Neighborhood Hits	159
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

STAM1_HUMAN
θ value	3.77169e-06 (rank : 40)	NC score	0.572088 (rank : 31)
Query Neighborhood Hits	358	Target Neighborhood Hits	271	Shared Neighborhood Hits	174
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	6.43352e-06 (rank : 41)	NC score	0.569330 (rank : 33)
Query Neighborhood Hits	358	Target Neighborhood Hits	273	Shared Neighborhood Hits	174
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN3_HUMAN
θ value	8.40245e-06 (rank : 42)	NC score	0.537200 (rank : 43)
Query Neighborhood Hits	358	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

STAC_MOUSE
θ value	8.40245e-06 (rank : 43)	NC score	0.561435 (rank : 35)
Query Neighborhood Hits	358	Target Neighborhood Hits	268	Shared Neighborhood Hits	160
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

LASP1_HUMAN
θ value	1.09739e-05 (rank : 44)	NC score	0.535480 (rank : 46)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	148
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	1.09739e-05 (rank : 45)	NC score	0.531101 (rank : 48)
Query Neighborhood Hits	358	Target Neighborhood Hits	297	Shared Neighborhood Hits	148
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

OSTF1_HUMAN
θ value	1.09739e-05 (rank : 46)	NC score	0.475894 (rank : 64)
Query Neighborhood Hits	358	Target Neighborhood Hits	466	Shared Neighborhood Hits	174
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PLCG1_MOUSE
θ value	1.09739e-05 (rank : 47)	NC score	0.407975 (rank : 85)
Query Neighborhood Hits	358	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VINEX_MOUSE
θ value	1.09739e-05 (rank : 48)	NC score	0.609126 (rank : 18)
Query Neighborhood Hits	358	Target Neighborhood Hits	286	Shared Neighborhood Hits	178
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ARHG7_HUMAN
θ value	1.43324e-05 (rank : 49)	NC score	0.519037 (rank : 56)
Query Neighborhood Hits	358	Target Neighborhood Hits	347	Shared Neighborhood Hits	171
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

NEBL_HUMAN
θ value	1.43324e-05 (rank : 50)	NC score	0.477255 (rank : 63)
Query Neighborhood Hits	358	Target Neighborhood Hits	457	Shared Neighborhood Hits	152
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RGS3_MOUSE
θ value	1.43324e-05 (rank : 51)	NC score	0.107823 (rank : 220)
Query Neighborhood Hits	358	Target Neighborhood Hits	1621	Shared Neighborhood Hits	171
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BCAR1_HUMAN
θ value	1.87187e-05 (rank : 52)	NC score	0.465190 (rank : 69)
Query Neighborhood Hits	358	Target Neighborhood Hits	554	Shared Neighborhood Hits	220
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ARHG7_MOUSE
θ value	2.44474e-05 (rank : 53)	NC score	0.522223 (rank : 53)
Query Neighborhood Hits	358	Target Neighborhood Hits	396	Shared Neighborhood Hits	173
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_HUMAN
θ value	2.44474e-05 (rank : 54)	NC score	0.530614 (rank : 49)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	178
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

M3KL4_HUMAN
θ value	2.44474e-05 (rank : 55)	NC score	0.183734 (rank : 146)
Query Neighborhood Hits	358	Target Neighborhood Hits	1087	Shared Neighborhood Hits	178
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NEBU_HUMAN
θ value	2.44474e-05 (rank : 56)	NC score	0.431439 (rank : 76)
Query Neighborhood Hits	358	Target Neighborhood Hits	420	Shared Neighborhood Hits	156
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAM2_MOUSE
θ value	2.44474e-05 (rank : 57)	NC score	0.552341 (rank : 39)
Query Neighborhood Hits	358	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VINEX_HUMAN
θ value	2.44474e-05 (rank : 58)	NC score	0.610169 (rank : 17)
Query Neighborhood Hits	358	Target Neighborhood Hits	270	Shared Neighborhood Hits	175
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CASL_MOUSE
θ value	3.19293e-05 (rank : 59)	NC score	0.430609 (rank : 77)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	148
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
θ value	3.19293e-05 (rank : 60)	NC score	0.500352 (rank : 58)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

NCK1_HUMAN
θ value	3.19293e-05 (rank : 61)	NC score	0.536445 (rank : 45)
Query Neighborhood Hits	358	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAM2_HUMAN
θ value	3.19293e-05 (rank : 62)	NC score	0.541081 (rank : 42)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	171
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SRGP2_HUMAN
θ value	4.1701e-05 (rank : 63)	NC score	0.315601 (rank : 108)
Query Neighborhood Hits	358	Target Neighborhood Hits	331	Shared Neighborhood Hits	149
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CASL_HUMAN
θ value	5.44631e-05 (rank : 64)	NC score	0.428256 (rank : 78)
Query Neighborhood Hits	358	Target Neighborhood Hits	259	Shared Neighborhood Hits	154
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

GRAP_MOUSE
θ value	5.44631e-05 (rank : 65)	NC score	0.529729 (rank : 50)
Query Neighborhood Hits	358	Target Neighborhood Hits	309	Shared Neighborhood Hits	176
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PLCG1_HUMAN
θ value	5.44631e-05 (rank : 66)	NC score	0.390645 (rank : 92)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRGP2_MOUSE
θ value	5.44631e-05 (rank : 67)	NC score	0.320126 (rank : 107)
Query Neighborhood Hits	358	Target Neighborhood Hits	324	Shared Neighborhood Hits	150
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

BCAR1_MOUSE
θ value	7.1131e-05 (rank : 68)	NC score	0.463584 (rank : 71)
Query Neighborhood Hits	358	Target Neighborhood Hits	438	Shared Neighborhood Hits	201
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NCF4_MOUSE
θ value	9.29e-05 (rank : 69)	NC score	0.569616 (rank : 32)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	141
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC3_HUMAN
θ value	9.29e-05 (rank : 70)	NC score	0.520134 (rank : 55)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	9.29e-05 (rank : 71)	NC score	0.520986 (rank : 54)
Query Neighborhood Hits	358	Target Neighborhood Hits	232	Shared Neighborhood Hits	145
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV_HUMAN
θ value	9.29e-05 (rank : 72)	NC score	0.444201 (rank : 73)
Query Neighborhood Hits	358	Target Neighborhood Hits	452	Shared Neighborhood Hits	166
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	9.29e-05 (rank : 73)	NC score	0.445256 (rank : 72)
Query Neighborhood Hits	358	Target Neighborhood Hits	430	Shared Neighborhood Hits	163
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

FGR_HUMAN
θ value	0.000121331 (rank : 74)	NC score	0.169544 (rank : 152)
Query Neighborhood Hits	358	Target Neighborhood Hits	1067	Shared Neighborhood Hits	172
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RHG04_HUMAN
θ value	0.000121331 (rank : 75)	NC score	0.356836 (rank : 101)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	157
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

M3K9_HUMAN
θ value	0.000158464 (rank : 76)	NC score	0.162105 (rank : 165)
Query Neighborhood Hits	358	Target Neighborhood Hits	1123	Shared Neighborhood Hits	189
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SPTA1_MOUSE
θ value	0.00020696 (rank : 77)	NC score	0.240497 (rank : 133)
Query Neighborhood Hits	358	Target Neighborhood Hits	675	Shared Neighborhood Hits	154
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_HUMAN
θ value	0.00020696 (rank : 78)	NC score	0.575459 (rank : 29)
Query Neighborhood Hits	358	Target Neighborhood Hits	396	Shared Neighborhood Hits	180
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	0.00020696 (rank : 79)	NC score	0.582156 (rank : 26)
Query Neighborhood Hits	358	Target Neighborhood Hits	409	Shared Neighborhood Hits	191
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

M3K11_HUMAN
θ value	0.000270298 (rank : 80)	NC score	0.168929 (rank : 154)
Query Neighborhood Hits	358	Target Neighborhood Hits	1136	Shared Neighborhood Hits	190
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NCF4_HUMAN
θ value	0.000270298 (rank : 81)	NC score	0.545811 (rank : 40)
Query Neighborhood Hits	358	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VAV3_HUMAN
θ value	0.000270298 (rank : 82)	NC score	0.395911 (rank : 91)
Query Neighborhood Hits	358	Target Neighborhood Hits	398	Shared Neighborhood Hits	164
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PPIP1_MOUSE
θ value	0.00035302 (rank : 83)	NC score	0.535414 (rank : 47)
Query Neighborhood Hits	358	Target Neighborhood Hits	377	Shared Neighborhood Hits	173
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

VAV2_HUMAN
θ value	0.00035302 (rank : 84)	NC score	0.416767 (rank : 83)
Query Neighborhood Hits	358	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.00035302 (rank : 85)	NC score	0.417717 (rank : 82)
Query Neighborhood Hits	358	Target Neighborhood Hits	456	Shared Neighborhood Hits	166
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DOCK1_HUMAN
θ value	0.000461057 (rank : 86)	NC score	0.224287 (rank : 137)
Query Neighborhood Hits	358	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SPTA1_HUMAN
θ value	0.000461057 (rank : 87)	NC score	0.235316 (rank : 135)
Query Neighborhood Hits	358	Target Neighborhood Hits	748	Shared Neighborhood Hits	163
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

AHI1_HUMAN
θ value	0.000602161 (rank : 88)	NC score	0.406967 (rank : 86)
Query Neighborhood Hits	358	Target Neighborhood Hits	537	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	0.000602161 (rank : 89)	NC score	0.406059 (rank : 87)
Query Neighborhood Hits	358	Target Neighborhood Hits	496	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG6_HUMAN
θ value	0.000786445 (rank : 90)	NC score	0.483962 (rank : 62)
Query Neighborhood Hits	358	Target Neighborhood Hits	376	Shared Neighborhood Hits	165
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.000786445 (rank : 91)	NC score	0.488111 (rank : 61)
Query Neighborhood Hits	358	Target Neighborhood Hits	394	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DNMBP_HUMAN
θ value	0.000786445 (rank : 92)	NC score	0.498401 (rank : 59)
Query Neighborhood Hits	358	Target Neighborhood Hits	413	Shared Neighborhood Hits	184
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF2_HUMAN
θ value	0.000786445 (rank : 93)	NC score	0.618350 (rank : 13)
Query Neighborhood Hits	358	Target Neighborhood Hits	229	Shared Neighborhood Hits	153
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SPTA2_HUMAN
θ value	0.00102713 (rank : 94)	NC score	0.248131 (rank : 130)
Query Neighborhood Hits	358	Target Neighborhood Hits	888	Shared Neighborhood Hits	166
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DNMBP_MOUSE
θ value	0.00134147 (rank : 95)	NC score	0.491608 (rank : 60)
Query Neighborhood Hits	358	Target Neighborhood Hits	435	Shared Neighborhood Hits	191
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FGR_MOUSE
θ value	0.00134147 (rank : 96)	NC score	0.163456 (rank : 163)
Query Neighborhood Hits	358	Target Neighborhood Hits	1069	Shared Neighborhood Hits	173
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRGP1_HUMAN
θ value	0.00134147 (rank : 97)	NC score	0.300606 (rank : 111)
Query Neighborhood Hits	358	Target Neighborhood Hits	390	Shared Neighborhood Hits	146
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TCGAP_HUMAN
θ value	0.00134147 (rank : 98)	NC score	0.257307 (rank : 128)
Query Neighborhood Hits	358	Target Neighborhood Hits	872	Shared Neighborhood Hits	201
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ARHG9_HUMAN
θ value	0.00175202 (rank : 99)	NC score	0.364947 (rank : 100)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	147
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.00175202 (rank : 100)	NC score	0.367492 (rank : 98)
Query Neighborhood Hits	358	Target Neighborhood Hits	234	Shared Neighborhood Hits	148
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	0.00175202 (rank : 101)	NC score	0.296310 (rank : 113)
Query Neighborhood Hits	358	Target Neighborhood Hits	956	Shared Neighborhood Hits	190
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PPIP1_HUMAN
θ value	0.00175202 (rank : 102)	NC score	0.525162 (rank : 52)
Query Neighborhood Hits	358	Target Neighborhood Hits	389	Shared Neighborhood Hits	173
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

TCGAP_MOUSE
θ value	0.00175202 (rank : 103)	NC score	0.262393 (rank : 126)
Query Neighborhood Hits	358	Target Neighborhood Hits	409	Shared Neighborhood Hits	136
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ASPP1_MOUSE
θ value	0.00228821 (rank : 104)	NC score	0.306637 (rank : 110)
Query Neighborhood Hits	358	Target Neighborhood Hits	1244	Shared Neighborhood Hits	238
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

FNBP2_HUMAN
θ value	0.00228821 (rank : 105)	NC score	0.298407 (rank : 112)
Query Neighborhood Hits	358	Target Neighborhood Hits	432	Shared Neighborhood Hits	157
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

M3K10_HUMAN
θ value	0.00228821 (rank : 106)	NC score	0.148166 (rank : 179)
Query Neighborhood Hits	358	Target Neighborhood Hits	1071	Shared Neighborhood Hits	164
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

SON_MOUSE
θ value	0.00228821 (rank : 107)	NC score	0.078081 (rank : 310)
Query Neighborhood Hits	358	Target Neighborhood Hits	957	Shared Neighborhood Hits	113
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

VAV3_MOUSE
θ value	0.00228821 (rank : 108)	NC score	0.387884 (rank : 93)
Query Neighborhood Hits	358	Target Neighborhood Hits	404	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG2_HUMAN
θ value	0.00298849 (rank : 109)	NC score	0.384233 (rank : 94)
Query Neighborhood Hits	358	Target Neighborhood Hits	280	Shared Neighborhood Hits	147
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ARHG4_HUMAN
θ value	0.00390308 (rank : 110)	NC score	0.381574 (rank : 95)
Query Neighborhood Hits	358	Target Neighborhood Hits	242	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CRKL_HUMAN
θ value	0.00665767 (rank : 111)	NC score	0.473869 (rank : 66)
Query Neighborhood Hits	358	Target Neighborhood Hits	313	Shared Neighborhood Hits	170
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NOXO1_MOUSE
θ value	0.00665767 (rank : 112)	NC score	0.352205 (rank : 102)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

EFS_HUMAN
θ value	0.00869519 (rank : 113)	NC score	0.414121 (rank : 84)
Query Neighborhood Hits	358	Target Neighborhood Hits	348	Shared Neighborhood Hits	170
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.00869519 (rank : 114)	NC score	0.420400 (rank : 80)
Query Neighborhood Hits	358	Target Neighborhood Hits	389	Shared Neighborhood Hits	180
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SNX18_HUMAN
θ value	0.00869519 (rank : 115)	NC score	0.366273 (rank : 99)
Query Neighborhood Hits	358	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.00869519 (rank : 116)	NC score	0.370061 (rank : 97)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ABI3_MOUSE
θ value	0.0113563 (rank : 117)	NC score	0.525623 (rank : 51)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CRKL_MOUSE
θ value	0.0113563 (rank : 118)	NC score	0.463729 (rank : 70)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	163
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FYN_HUMAN
θ value	0.0113563 (rank : 119)	NC score	0.166144 (rank : 157)
Query Neighborhood Hits	358	Target Neighborhood Hits	1078	Shared Neighborhood Hits	176
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0113563 (rank : 120)	NC score	0.169412 (rank : 153)
Query Neighborhood Hits	358	Target Neighborhood Hits	1073	Shared Neighborhood Hits	177
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

RHG26_HUMAN
θ value	0.0148317 (rank : 121)	NC score	0.289375 (rank : 117)
Query Neighborhood Hits	358	Target Neighborhood Hits	281	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

YES_MOUSE
θ value	0.0148317 (rank : 122)	NC score	0.165244 (rank : 158)
Query Neighborhood Hits	358	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FRK_HUMAN
θ value	0.0193708 (rank : 123)	NC score	0.136547 (rank : 186)
Query Neighborhood Hits	358	Target Neighborhood Hits	1058	Shared Neighborhood Hits	174
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

IASPP_HUMAN
θ value	0.0193708 (rank : 124)	NC score	0.312546 (rank : 109)
Query Neighborhood Hits	358	Target Neighborhood Hits	688	Shared Neighborhood Hits	180
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	0.0193708 (rank : 125)	NC score	0.296209 (rank : 114)
Query Neighborhood Hits	358	Target Neighborhood Hits	1024	Shared Neighborhood Hits	221
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

YES_HUMAN
θ value	0.0193708 (rank : 126)	NC score	0.163492 (rank : 162)
Query Neighborhood Hits	358	Target Neighborhood Hits	1059	Shared Neighborhood Hits	173
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ABI3_HUMAN
θ value	0.0252991 (rank : 127)	NC score	0.515356 (rank : 57)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	140
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

IWS1_HUMAN
θ value	0.0252991 (rank : 128)	NC score	0.058531 (rank : 407)
Query Neighborhood Hits	358	Target Neighborhood Hits	1241	Shared Neighborhood Hits	91
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
θ value	0.0252991 (rank : 129)	NC score	0.065801 (rank : 360)
Query Neighborhood Hits	358	Target Neighborhood Hits	1258	Shared Neighborhood Hits	99
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RUSC1_MOUSE
θ value	0.0252991 (rank : 130)	NC score	0.333527 (rank : 106)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SRC_HUMAN
θ value	0.0252991 (rank : 131)	NC score	0.162257 (rank : 164)
Query Neighborhood Hits	358	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

DDEF1_MOUSE
θ value	0.0330416 (rank : 132)	NC score	0.266109 (rank : 124)
Query Neighborhood Hits	358	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

HCK_MOUSE
θ value	0.0330416 (rank : 133)	NC score	0.145117 (rank : 180)
Query Neighborhood Hits	358	Target Neighborhood Hits	1029	Shared Neighborhood Hits	171
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

AMPH_MOUSE
θ value	0.0431538 (rank : 134)	NC score	0.198198 (rank : 143)
Query Neighborhood Hits	358	Target Neighborhood Hits	291	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SHLB1_HUMAN
θ value	0.0431538 (rank : 135)	NC score	0.288556 (rank : 118)
Query Neighborhood Hits	358	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

CSK_HUMAN
θ value	0.0563607 (rank : 136)	NC score	0.120944 (rank : 203)
Query Neighborhood Hits	358	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.0563607 (rank : 137)	NC score	0.121049 (rank : 202)
Query Neighborhood Hits	358	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PTN22_MOUSE
θ value	0.0563607 (rank : 138)	NC score	0.021794 (rank : 537)
Query Neighborhood Hits	358	Target Neighborhood Hits	179	Shared Neighborhood Hits	23
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

SRC_MOUSE
θ value	0.0563607 (rank : 139)	NC score	0.140001 (rank : 185)
Query Neighborhood Hits	358	Target Neighborhood Hits	1033	Shared Neighborhood Hits	158
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

WASF1_HUMAN
θ value	0.0563607 (rank : 140)	NC score	0.057087 (rank : 413)
Query Neighborhood Hits	358	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	0.0563607 (rank : 141)	NC score	0.056933 (rank : 416)
Query Neighborhood Hits	358	Target Neighborhood Hits	261	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

NPHP1_MOUSE
θ value	0.0736092 (rank : 142)	NC score	0.428146 (rank : 79)
Query Neighborhood Hits	358	Target Neighborhood Hits	267	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

AMPH_HUMAN
θ value	0.0961366 (rank : 143)	NC score	0.200888 (rank : 142)
Query Neighborhood Hits	358	Target Neighborhood Hits	455	Shared Neighborhood Hits	122
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SHLB1_MOUSE
θ value	0.0961366 (rank : 144)	NC score	0.293832 (rank : 115)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

TEC_HUMAN
θ value	0.0961366 (rank : 145)	NC score	0.116576 (rank : 212)
Query Neighborhood Hits	358	Target Neighborhood Hits	1006	Shared Neighborhood Hits	138
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

HCK_HUMAN
θ value	0.125558 (rank : 146)	NC score	0.143022 (rank : 181)
Query Neighborhood Hits	358	Target Neighborhood Hits	1035	Shared Neighborhood Hits	172
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MLL4_HUMAN
θ value	0.125558 (rank : 147)	NC score	0.064673 (rank : 365)
Query Neighborhood Hits	358	Target Neighborhood Hits	722	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

TITIN_HUMAN
θ value	0.125558 (rank : 148)	NC score	0.024607 (rank : 527)
Query Neighborhood Hits	358	Target Neighborhood Hits	2923	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

BRD8_MOUSE
θ value	0.163984 (rank : 149)	NC score	0.051188 (rank : 450)
Query Neighborhood Hits	358	Target Neighborhood Hits	422	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

BTK_HUMAN
θ value	0.163984 (rank : 150)	NC score	0.142659 (rank : 182)
Query Neighborhood Hits	358	Target Neighborhood Hits	1026	Shared Neighborhood Hits	171
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DOCK2_HUMAN
θ value	0.163984 (rank : 151)	NC score	0.100536 (rank : 236)
Query Neighborhood Hits	358	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

NOXO1_HUMAN
θ value	0.163984 (rank : 152)	NC score	0.266552 (rank : 123)
Query Neighborhood Hits	358	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

RERE_MOUSE
θ value	0.163984 (rank : 153)	NC score	0.064281 (rank : 369)
Query Neighborhood Hits	358	Target Neighborhood Hits	785	Shared Neighborhood Hits	74
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RUSC1_HUMAN
θ value	0.163984 (rank : 154)	NC score	0.340642 (rank : 105)
Query Neighborhood Hits	358	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC2_MOUSE
θ value	0.163984 (rank : 155)	NC score	0.127549 (rank : 195)
Query Neighborhood Hits	358	Target Neighborhood Hits	305	Shared Neighborhood Hits	92
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SFPQ_HUMAN
θ value	0.163984 (rank : 156)	NC score	0.042264 (rank : 473)
Query Neighborhood Hits	358	Target Neighborhood Hits	986	Shared Neighborhood Hits	66
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

TEC_MOUSE
θ value	0.163984 (rank : 157)	NC score	0.111848 (rank : 215)
Query Neighborhood Hits	358	Target Neighborhood Hits	1006	Shared Neighborhood Hits	138
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHG4_MOUSE
θ value	0.21417 (rank : 158)	NC score	0.293753 (rank : 116)
Query Neighborhood Hits	358	Target Neighborhood Hits	185	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CRK_HUMAN
θ value	0.21417 (rank : 159)	NC score	0.436226 (rank : 75)
Query Neighborhood Hits	358	Target Neighborhood Hits	308	Shared Neighborhood Hits	163
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.21417 (rank : 160)	NC score	0.442759 (rank : 74)
Query Neighborhood Hits	358	Target Neighborhood Hits	314	Shared Neighborhood Hits	165
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CS016_HUMAN
θ value	0.21417 (rank : 161)	NC score	0.068893 (rank : 346)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	54
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DDEF2_HUMAN
θ value	0.21417 (rank : 162)	NC score	0.234213 (rank : 136)
Query Neighborhood Hits	358	Target Neighborhood Hits	599	Shared Neighborhood Hits	161
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.21417 (rank : 163)	NC score	0.237317 (rank : 134)
Query Neighborhood Hits	358	Target Neighborhood Hits	625	Shared Neighborhood Hits	157
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HRX_HUMAN
θ value	0.21417 (rank : 164)	NC score	0.057706 (rank : 411)
Query Neighborhood Hits	358	Target Neighborhood Hits	825	Shared Neighborhood Hits	79
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

NCF1_HUMAN
θ value	0.21417 (rank : 165)	NC score	0.469392 (rank : 68)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	144
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

RERE_HUMAN
θ value	0.21417 (rank : 166)	NC score	0.066154 (rank : 358)
Query Neighborhood Hits	358	Target Neighborhood Hits	779	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SHAN2_MOUSE
θ value	0.21417 (rank : 167)	NC score	0.214474 (rank : 140)
Query Neighborhood Hits	358	Target Neighborhood Hits	446	Shared Neighborhood Hits	120
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SMAD9_HUMAN
θ value	0.21417 (rank : 168)	NC score	0.015990 (rank : 555)
Query Neighborhood Hits	358	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

ASPP2_HUMAN
θ value	0.279714 (rank : 169)	NC score	0.222304 (rank : 138)
Query Neighborhood Hits	358	Target Neighborhood Hits	1156	Shared Neighborhood Hits	180
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

MNT_MOUSE
θ value	0.279714 (rank : 170)	NC score	0.064680 (rank : 364)
Query Neighborhood Hits	358	Target Neighborhood Hits	432	Shared Neighborhood Hits	61
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SHAN1_HUMAN
θ value	0.279714 (rank : 171)	NC score	0.176344 (rank : 148)
Query Neighborhood Hits	358	Target Neighborhood Hits	1041	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SOS2_HUMAN
θ value	0.279714 (rank : 172)	NC score	0.052876 (rank : 444)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

YLPM1_MOUSE
θ value	0.279714 (rank : 173)	NC score	0.069915 (rank : 344)
Query Neighborhood Hits	358	Target Neighborhood Hits	505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

CJ078_MOUSE
θ value	0.365318 (rank : 174)	NC score	0.061781 (rank : 382)
Query Neighborhood Hits	358	Target Neighborhood Hits	559	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

DOK2_HUMAN
θ value	0.365318 (rank : 175)	NC score	0.023712 (rank : 530)
Query Neighborhood Hits	358	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

NCF1_MOUSE
θ value	0.365318 (rank : 176)	NC score	0.470347 (rank : 67)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	149
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PRDM2_HUMAN
θ value	0.365318 (rank : 177)	NC score	0.015516 (rank : 557)
Query Neighborhood Hits	358	Target Neighborhood Hits	1135	Shared Neighborhood Hits	65
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

RGS3_HUMAN
θ value	0.365318 (rank : 178)	NC score	0.079100 (rank : 303)
Query Neighborhood Hits	358	Target Neighborhood Hits	1375	Shared Neighborhood Hits	151
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ZBTB5_MOUSE
θ value	0.365318 (rank : 179)	NC score	-0.001080 (rank : 577)
Query Neighborhood Hits	358	Target Neighborhood Hits	801	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG0, Q3TVR7, Q6GV09, Q8BIB5	Gene names	Zbtb5, Kiaa0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5 (Transcription factor ZNF-POZ).

CBLB_HUMAN
θ value	0.47712 (rank : 180)	NC score	0.021949 (rank : 536)
Query Neighborhood Hits	358	Target Neighborhood Hits	261	Shared Neighborhood Hits	16
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CSKI1_HUMAN
θ value	0.47712 (rank : 181)	NC score	0.049517 (rank : 459)
Query Neighborhood Hits	358	Target Neighborhood Hits	997	Shared Neighborhood Hits	127
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DOCK4_MOUSE
θ value	0.47712 (rank : 182)	NC score	0.068740 (rank : 347)
Query Neighborhood Hits	358	Target Neighborhood Hits	210	Shared Neighborhood Hits	50
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

FBLI1_HUMAN
θ value	0.47712 (rank : 183)	NC score	0.024679 (rank : 525)
Query Neighborhood Hits	358	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

ITK_MOUSE
θ value	0.47712 (rank : 184)	NC score	0.099154 (rank : 241)
Query Neighborhood Hits	358	Target Neighborhood Hits	985	Shared Neighborhood Hits	121
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

WIRE_MOUSE
θ value	0.47712 (rank : 185)	NC score	0.067143 (rank : 351)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

BTK_MOUSE
θ value	0.62314 (rank : 186)	NC score	0.134870 (rank : 190)
Query Neighborhood Hits	358	Target Neighborhood Hits	1017	Shared Neighborhood Hits	161
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FMNL_MOUSE
θ value	0.62314 (rank : 187)	NC score	0.040002 (rank : 481)
Query Neighborhood Hits	358	Target Neighborhood Hits	428	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

NFH_MOUSE
θ value	0.62314 (rank : 188)	NC score	0.049968 (rank : 458)
Query Neighborhood Hits	358	Target Neighborhood Hits	2247	Shared Neighborhood Hits	158
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

WIRE_HUMAN
θ value	0.62314 (rank : 189)	NC score	0.066790 (rank : 354)
Query Neighborhood Hits	358	Target Neighborhood Hits	329	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

YLPM1_HUMAN
θ value	0.62314 (rank : 190)	NC score	0.069355 (rank : 345)
Query Neighborhood Hits	358	Target Neighborhood Hits	670	Shared Neighborhood Hits	73
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

AB1IP_MOUSE
θ value	0.813845 (rank : 191)	NC score	0.038753 (rank : 487)
Query Neighborhood Hits	358	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ANM2_HUMAN
θ value	0.813845 (rank : 192)	NC score	0.274788 (rank : 122)
Query Neighborhood Hits	358	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANTR1_MOUSE
θ value	0.813845 (rank : 193)	NC score	0.027508 (rank : 519)
Query Neighborhood Hits	358	Target Neighborhood Hits	143	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

BAT2_HUMAN
θ value	0.813845 (rank : 194)	NC score	0.082549 (rank : 292)
Query Neighborhood Hits	358	Target Neighborhood Hits	931	Shared Neighborhood Hits	113
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BRD8_HUMAN
θ value	0.813845 (rank : 195)	NC score	0.039656 (rank : 483)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

FBLI1_MOUSE
θ value	0.813845 (rank : 196)	NC score	0.024258 (rank : 528)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

ITK_HUMAN
θ value	0.813845 (rank : 197)	NC score	0.104414 (rank : 227)
Query Neighborhood Hits	358	Target Neighborhood Hits	1016	Shared Neighborhood Hits	133
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MICA1_HUMAN
θ value	0.813845 (rank : 198)	NC score	0.023435 (rank : 531)
Query Neighborhood Hits	358	Target Neighborhood Hits	279	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MLL2_HUMAN
θ value	0.813845 (rank : 199)	NC score	0.059681 (rank : 401)
Query Neighborhood Hits	358	Target Neighborhood Hits	1788	Shared Neighborhood Hits	122
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PELP1_MOUSE
θ value	0.813845 (rank : 200)	NC score	0.063323 (rank : 374)
Query Neighborhood Hits	358	Target Neighborhood Hits	709	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

RBM12_MOUSE
θ value	0.813845 (rank : 201)	NC score	0.037638 (rank : 490)
Query Neighborhood Hits	358	Target Neighborhood Hits	313	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

RTN4_MOUSE
θ value	0.813845 (rank : 202)	NC score	0.054226 (rank : 432)
Query Neighborhood Hits	358	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

TXK_MOUSE
θ value	0.813845 (rank : 203)	NC score	0.115834 (rank : 214)
Query Neighborhood Hits	358	Target Neighborhood Hits	980	Shared Neighborhood Hits	134
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LYN_MOUSE
θ value	1.06291 (rank : 204)	NC score	0.127348 (rank : 196)
Query Neighborhood Hits	358	Target Neighborhood Hits	1023	Shared Neighborhood Hits	157
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MDC1_HUMAN
θ value	1.06291 (rank : 205)	NC score	0.097011 (rank : 248)
Query Neighborhood Hits	358	Target Neighborhood Hits	1446	Shared Neighborhood Hits	134
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NPHP1_HUMAN
θ value	1.06291 (rank : 206)	NC score	0.372413 (rank : 96)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	140
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PRG4_HUMAN
θ value	1.06291 (rank : 207)	NC score	0.054130 (rank : 433)
Query Neighborhood Hits	358	Target Neighborhood Hits	764	Shared Neighborhood Hits	77
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RAPH1_HUMAN
θ value	1.06291 (rank : 208)	NC score	0.066371 (rank : 357)
Query Neighborhood Hits	358	Target Neighborhood Hits	593	Shared Neighborhood Hits	87
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RHG25_MOUSE
θ value	1.06291 (rank : 209)	NC score	0.063148 (rank : 375)
Query Neighborhood Hits	358	Target Neighborhood Hits	492	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SELV_HUMAN
θ value	1.06291 (rank : 210)	NC score	0.047294 (rank : 464)
Query Neighborhood Hits	358	Target Neighborhood Hits	118	Shared Neighborhood Hits	24
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

SET1A_HUMAN
θ value	1.06291 (rank : 211)	NC score	0.059729 (rank : 399)
Query Neighborhood Hits	358	Target Neighborhood Hits	690	Shared Neighborhood Hits	63
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

WASF2_MOUSE
θ value	1.06291 (rank : 212)	NC score	0.053439 (rank : 438)
Query Neighborhood Hits	358	Target Neighborhood Hits	315	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ANR11_HUMAN
θ value	1.38821 (rank : 213)	NC score	0.048223 (rank : 461)
Query Neighborhood Hits	358	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

BAT3_HUMAN
θ value	1.38821 (rank : 214)	NC score	0.042573 (rank : 472)
Query Neighborhood Hits	358	Target Neighborhood Hits	490	Shared Neighborhood Hits	68
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CCNK_MOUSE
θ value	1.38821 (rank : 215)	NC score	0.049443 (rank : 460)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	47
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

DOCK4_HUMAN
θ value	1.38821 (rank : 216)	NC score	0.064789 (rank : 363)
Query Neighborhood Hits	358	Target Neighborhood Hits	237	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

EP400_HUMAN
θ value	1.38821 (rank : 217)	NC score	0.021041 (rank : 542)
Query Neighborhood Hits	358	Target Neighborhood Hits	556	Shared Neighborhood Hits	52
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FMN1A_MOUSE
θ value	1.38821 (rank : 218)	NC score	0.039633 (rank : 484)
Query Neighborhood Hits	358	Target Neighborhood Hits	423	Shared Neighborhood Hits	47
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	1.38821 (rank : 219)	NC score	0.039319 (rank : 486)
Query Neighborhood Hits	358	Target Neighborhood Hits	447	Shared Neighborhood Hits	50
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

GP1BA_HUMAN
θ value	1.38821 (rank : 220)	NC score	0.009585 (rank : 565)
Query Neighborhood Hits	358	Target Neighborhood Hits	407	Shared Neighborhood Hits	24
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

LYN_HUMAN
θ value	1.38821 (rank : 221)	NC score	0.127869 (rank : 194)
Query Neighborhood Hits	358	Target Neighborhood Hits	1022	Shared Neighborhood Hits	156
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MDC1_MOUSE
θ value	1.38821 (rank : 222)	NC score	0.080747 (rank : 299)
Query Neighborhood Hits	358	Target Neighborhood Hits	998	Shared Neighborhood Hits	127
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MISS_MOUSE
θ value	1.38821 (rank : 223)	NC score	0.061836 (rank : 381)
Query Neighborhood Hits	358	Target Neighborhood Hits	444	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

PRG4_MOUSE
θ value	1.38821 (rank : 224)	NC score	0.047554 (rank : 463)
Query Neighborhood Hits	358	Target Neighborhood Hits	624	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PTN22_HUMAN
θ value	1.38821 (rank : 225)	NC score	0.014954 (rank : 558)
Query Neighborhood Hits	358	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

SIA7A_MOUSE
θ value	1.38821 (rank : 226)	NC score	0.020501 (rank : 543)
Query Neighborhood Hits	358	Target Neighborhood Hits	203	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

TNR8_HUMAN
θ value	1.38821 (rank : 227)	NC score	0.018997 (rank : 548)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

ZN509_MOUSE
θ value	1.38821 (rank : 228)	NC score	-0.005319 (rank : 580)
Query Neighborhood Hits	358	Target Neighborhood Hits	990	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ANK2_HUMAN
θ value	1.81305 (rank : 229)	NC score	0.045582 (rank : 467)
Query Neighborhood Hits	358	Target Neighborhood Hits	1615	Shared Neighborhood Hits	133
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANM2_MOUSE
θ value	1.81305 (rank : 230)	NC score	0.255121 (rank : 129)
Query Neighborhood Hits	358	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BAT2_MOUSE
θ value	1.81305 (rank : 231)	NC score	0.074866 (rank : 323)
Query Neighborhood Hits	358	Target Neighborhood Hits	947	Shared Neighborhood Hits	116
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BCL7C_MOUSE
θ value	1.81305 (rank : 232)	NC score	0.029142 (rank : 514)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

BRD4_MOUSE
θ value	1.81305 (rank : 233)	NC score	0.040464 (rank : 475)
Query Neighborhood Hits	358	Target Neighborhood Hits	845	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

DOCK2_MOUSE
θ value	1.81305 (rank : 234)	NC score	0.091255 (rank : 262)
Query Neighborhood Hits	358	Target Neighborhood Hits	104	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

ENAH_MOUSE
θ value	1.81305 (rank : 235)	NC score	0.050276 (rank : 456)
Query Neighborhood Hits	358	Target Neighborhood Hits	919	Shared Neighborhood Hits	81
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

IF35_HUMAN
θ value	1.81305 (rank : 236)	NC score	0.028576 (rank : 515)
Query Neighborhood Hits	358	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

MIA2_MOUSE
θ value	1.81305 (rank : 237)	NC score	0.053101 (rank : 441)
Query Neighborhood Hits	358	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MINK1_MOUSE
θ value	1.81305 (rank : 238)	NC score	0.030584 (rank : 510)
Query Neighborhood Hits	358	Target Neighborhood Hits	1451	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MY18B_HUMAN
θ value	1.81305 (rank : 239)	NC score	0.040299 (rank : 477)
Query Neighborhood Hits	358	Target Neighborhood Hits	1299	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

SETD8_MOUSE
θ value	1.81305 (rank : 240)	NC score	0.032183 (rank : 506)
Query Neighborhood Hits	358	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

WASIP_HUMAN
θ value	1.81305 (rank : 241)	NC score	0.072163 (rank : 333)
Query Neighborhood Hits	358	Target Neighborhood Hits	458	Shared Neighborhood Hits	63
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

3BP1_MOUSE
θ value	2.36792 (rank : 242)	NC score	0.071675 (rank : 335)
Query Neighborhood Hits	358	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ANK3_HUMAN
θ value	2.36792 (rank : 243)	NC score	0.025590 (rank : 524)
Query Neighborhood Hits	358	Target Neighborhood Hits	853	Shared Neighborhood Hits	62
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANTOL_HUMAN
θ value	2.36792 (rank : 244)	NC score	0.021268 (rank : 540)
Query Neighborhood Hits	358	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

K0562_HUMAN
θ value	2.36792 (rank : 245)	NC score	0.021215 (rank : 541)
Query Neighborhood Hits	358	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

M3K1_MOUSE
θ value	2.36792 (rank : 246)	NC score	0.024612 (rank : 526)
Query Neighborhood Hits	358	Target Neighborhood Hits	952	Shared Neighborhood Hits	47
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MINK1_HUMAN
θ value	2.36792 (rank : 247)	NC score	0.030612 (rank : 509)
Query Neighborhood Hits	358	Target Neighborhood Hits	1477	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PEX13_HUMAN
θ value	2.36792 (rank : 248)	NC score	0.348789 (rank : 103)
Query Neighborhood Hits	358	Target Neighborhood Hits	128	Shared Neighborhood Hits	105
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SETBP_HUMAN
θ value	2.36792 (rank : 249)	NC score	0.033561 (rank : 502)
Query Neighborhood Hits	358	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SYNJ1_MOUSE
θ value	2.36792 (rank : 250)	NC score	0.040433 (rank : 476)
Query Neighborhood Hits	358	Target Neighborhood Hits	516	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

WNK2_HUMAN
θ value	2.36792 (rank : 251)	NC score	0.048018 (rank : 462)
Query Neighborhood Hits	358	Target Neighborhood Hits	1407	Shared Neighborhood Hits	118
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

BAI1_HUMAN
θ value	3.0926 (rank : 252)	NC score	0.004183 (rank : 571)
Query Neighborhood Hits	358	Target Neighborhood Hits	375	Shared Neighborhood Hits	25
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BPL1_HUMAN
θ value	3.0926 (rank : 253)	NC score	0.020374 (rank : 544)
Query Neighborhood Hits	358	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P50747, Q99451	Gene names	HLCS
Domain Architecture
Description	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin-- [acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)].

CNTRB_MOUSE
θ value	3.0926 (rank : 254)	NC score	0.037455 (rank : 492)
Query Neighborhood Hits	358	Target Neighborhood Hits	1029	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

FOXB1_HUMAN
θ value	3.0926 (rank : 255)	NC score	0.004570 (rank : 570)
Query Neighborhood Hits	358	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q99853, O60652, O75917	Gene names	FOXB1, FKH5
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

FOXB1_MOUSE
θ value	3.0926 (rank : 256)	NC score	0.004645 (rank : 569)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q64732, O08753	Gene names	Foxb1, Fkh5, Foxb1a, Foxb1b, Mf3
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

MUC2_HUMAN
θ value	3.0926 (rank : 257)	NC score	0.033850 (rank : 501)
Query Neighborhood Hits	358	Target Neighborhood Hits	906	Shared Neighborhood Hits	60
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NCOR2_HUMAN
θ value	3.0926 (rank : 258)	NC score	0.045842 (rank : 466)
Query Neighborhood Hits	358	Target Neighborhood Hits	870	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PEX13_MOUSE
θ value	3.0926 (rank : 259)	NC score	0.347766 (rank : 104)
Query Neighborhood Hits	358	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PI5PA_MOUSE
θ value	3.0926 (rank : 260)	NC score	0.028480 (rank : 517)
Query Neighborhood Hits	358	Target Neighborhood Hits	331	Shared Neighborhood Hits	51
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

RPGF1_HUMAN
θ value	3.0926 (rank : 261)	NC score	0.035107 (rank : 496)
Query Neighborhood Hits	358	Target Neighborhood Hits	262	Shared Neighborhood Hits	56
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SASH1_HUMAN
θ value	3.0926 (rank : 262)	NC score	0.088449 (rank : 274)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	81
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SNX19_HUMAN
θ value	3.0926 (rank : 263)	NC score	0.023323 (rank : 532)
Query Neighborhood Hits	358	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

WNK1_MOUSE
θ value	3.0926 (rank : 264)	NC score	0.034921 (rank : 497)
Query Neighborhood Hits	358	Target Neighborhood Hits	1179	Shared Neighborhood Hits	82
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

AAK1_HUMAN
θ value	4.03905 (rank : 265)	NC score	0.033307 (rank : 504)
Query Neighborhood Hits	358	Target Neighborhood Hits	1077	Shared Neighborhood Hits	99
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ADDB_MOUSE
θ value	4.03905 (rank : 266)	NC score	0.026983 (rank : 521)
Query Neighborhood Hits	358	Target Neighborhood Hits	574	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

AKA12_HUMAN
θ value	4.03905 (rank : 267)	NC score	0.029598 (rank : 513)
Query Neighborhood Hits	358	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

CTDP1_HUMAN
θ value	4.03905 (rank : 268)	NC score	0.040046 (rank : 479)
Query Neighborhood Hits	358	Target Neighborhood Hits	416	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

GGA2_HUMAN
θ value	4.03905 (rank : 269)	NC score	0.034206 (rank : 499)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

LAD1_HUMAN
θ value	4.03905 (rank : 270)	NC score	0.054693 (rank : 429)
Query Neighborhood Hits	358	Target Neighborhood Hits	441	Shared Neighborhood Hits	61
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MNT_HUMAN
θ value	4.03905 (rank : 271)	NC score	0.060150 (rank : 394)
Query Neighborhood Hits	358	Target Neighborhood Hits	496	Shared Neighborhood Hits	66
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

PKN3_HUMAN
θ value	4.03905 (rank : 272)	NC score	0.018388 (rank : 550)
Query Neighborhood Hits	358	Target Neighborhood Hits	893	Shared Neighborhood Hits	49
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

RCOR2_HUMAN
θ value	4.03905 (rank : 273)	NC score	0.019704 (rank : 545)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZ40, Q96FP3	Gene names	RCOR2
Domain Architecture	No domain graphic available
Description	REST corepressor 2.

RIMB1_MOUSE
θ value	4.03905 (rank : 274)	NC score	0.150603 (rank : 175)
Query Neighborhood Hits	358	Target Neighborhood Hits	1376	Shared Neighborhood Hits	180
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SYNG_MOUSE
θ value	4.03905 (rank : 275)	NC score	0.043111 (rank : 471)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

WNK4_HUMAN
θ value	4.03905 (rank : 276)	NC score	0.030088 (rank : 511)
Query Neighborhood Hits	358	Target Neighborhood Hits	1043	Shared Neighborhood Hits	73
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ZN219_HUMAN
θ value	4.03905 (rank : 277)	NC score	-0.001959 (rank : 578)
Query Neighborhood Hits	358	Target Neighborhood Hits	876	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

ZN553_HUMAN
θ value	4.03905 (rank : 278)	NC score	-0.006663 (rank : 586)
Query Neighborhood Hits	358	Target Neighborhood Hits	760	Shared Neighborhood Hits	16
SwissProt Accessions	Q96MX3, Q4G0R3, Q69YP3, Q96IL9	Gene names	ZNF553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

CBLB_MOUSE
θ value	5.27518 (rank : 279)	NC score	0.017781 (rank : 552)
Query Neighborhood Hits	358	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CO039_MOUSE
θ value	5.27518 (rank : 280)	NC score	0.045375 (rank : 468)
Query Neighborhood Hits	358	Target Neighborhood Hits	445	Shared Neighborhood Hits	85
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

DGCR8_HUMAN
θ value	5.27518 (rank : 281)	NC score	0.035635 (rank : 495)
Query Neighborhood Hits	358	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DNJC8_HUMAN
θ value	5.27518 (rank : 282)	NC score	0.031853 (rank : 507)
Query Neighborhood Hits	358	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067	Gene names	DNAJC8, SPF31
Domain Architecture
Description	DnaJ homolog subfamily C member 8 (Splicing protein spf31).

DNJC8_MOUSE
θ value	5.27518 (rank : 283)	NC score	0.033320 (rank : 503)
Query Neighborhood Hits	358	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

EP300_HUMAN
θ value	5.27518 (rank : 284)	NC score	0.039474 (rank : 485)
Query Neighborhood Hits	358	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

IF39_HUMAN
θ value	5.27518 (rank : 285)	NC score	0.028562 (rank : 516)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	22
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

MINT_MOUSE
θ value	5.27518 (rank : 286)	NC score	0.058105 (rank : 408)
Query Neighborhood Hits	358	Target Neighborhood Hits	1514	Shared Neighborhood Hits	152
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

P85B_HUMAN
θ value	5.27518 (rank : 287)	NC score	0.135576 (rank : 188)
Query Neighborhood Hits	358	Target Neighborhood Hits	543	Shared Neighborhood Hits	84
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PDC6I_HUMAN
θ value	5.27518 (rank : 288)	NC score	0.026384 (rank : 523)
Query Neighborhood Hits	358	Target Neighborhood Hits	278	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

PDC6I_MOUSE
θ value	5.27518 (rank : 289)	NC score	0.021322 (rank : 539)
Query Neighborhood Hits	358	Target Neighborhood Hits	275	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

PRR12_HUMAN
θ value	5.27518 (rank : 290)	NC score	0.060604 (rank : 389)
Query Neighborhood Hits	358	Target Neighborhood Hits	460	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SF3A2_HUMAN
θ value	5.27518 (rank : 291)	NC score	0.044743 (rank : 469)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	34
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SPEG_MOUSE
θ value	5.27518 (rank : 292)	NC score	0.026921 (rank : 522)
Query Neighborhood Hits	358	Target Neighborhood Hits	1959	Shared Neighborhood Hits	132
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ZAN_HUMAN
θ value	5.27518 (rank : 293)	NC score	0.027240 (rank : 520)
Query Neighborhood Hits	358	Target Neighborhood Hits	679	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ZN500_HUMAN
θ value	5.27518 (rank : 294)	NC score	-0.006504 (rank : 585)
Query Neighborhood Hits	358	Target Neighborhood Hits	746	Shared Neighborhood Hits	17
SwissProt Accessions	O60304, Q96CQ8, Q9BTG0	Gene names	ZNF500, KIAA0557
Domain Architecture
Description	Zinc finger protein 500.

ZN579_HUMAN
θ value	5.27518 (rank : 295)	NC score	-0.005585 (rank : 583)
Query Neighborhood Hits	358	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NAF0	Gene names	ZNF579
Domain Architecture	No domain graphic available
Description	Zinc finger protein 579.

ZN579_MOUSE
θ value	5.27518 (rank : 296)	NC score	-0.005454 (rank : 582)
Query Neighborhood Hits	358	Target Neighborhood Hits	719	Shared Neighborhood Hits	17
SwissProt Accessions	Q80VM4	Gene names	Znf579, Zfp579
Domain Architecture	No domain graphic available
Description	Zinc finger protein 579.

AB1IP_HUMAN
θ value	6.88961 (rank : 297)	NC score	0.034350 (rank : 498)
Query Neighborhood Hits	358	Target Neighborhood Hits	213	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AL2S4_MOUSE
θ value	6.88961 (rank : 298)	NC score	0.037786 (rank : 489)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	44
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ANR40_MOUSE
θ value	6.88961 (rank : 299)	NC score	0.018371 (rank : 551)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ATBF1_HUMAN
θ value	6.88961 (rank : 300)	NC score	0.001511 (rank : 575)
Query Neighborhood Hits	358	Target Neighborhood Hits	1547	Shared Neighborhood Hits	61
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATF6B_HUMAN
θ value	6.88961 (rank : 301)	NC score	0.011812 (rank : 563)
Query Neighborhood Hits	358	Target Neighborhood Hits	122	Shared Neighborhood Hits	17
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

ATN1_HUMAN
θ value	6.88961 (rank : 302)	NC score	0.059494 (rank : 404)
Query Neighborhood Hits	358	Target Neighborhood Hits	676	Shared Neighborhood Hits	71
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BARD1_MOUSE
θ value	6.88961 (rank : 303)	NC score	0.022612 (rank : 533)
Query Neighborhood Hits	358	Target Neighborhood Hits	411	Shared Neighborhood Hits	19
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BCL7C_HUMAN
θ value	6.88961 (rank : 304)	NC score	0.021347 (rank : 538)
Query Neighborhood Hits	358	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WUZ0, O43770, Q6PD89	Gene names	BCL7C
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C.

BLNK_HUMAN
θ value	6.88961 (rank : 305)	NC score	0.078916 (rank : 304)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DLG4_MOUSE
θ value	6.88961 (rank : 306)	NC score	0.036793 (rank : 494)
Query Neighborhood Hits	358	Target Neighborhood Hits	282	Shared Neighborhood Hits	61
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

EPS8_MOUSE
θ value	6.88961 (rank : 307)	NC score	0.167206 (rank : 155)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	114
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HXA3_HUMAN
θ value	6.88961 (rank : 308)	NC score	0.002292 (rank : 574)
Query Neighborhood Hits	358	Target Neighborhood Hits	535	Shared Neighborhood Hits	36
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

LRC56_HUMAN
θ value	6.88961 (rank : 309)	NC score	0.012278 (rank : 562)
Query Neighborhood Hits	358	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

MOT8_HUMAN
θ value	6.88961 (rank : 310)	NC score	0.009700 (rank : 564)
Query Neighborhood Hits	358	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	P36021, Q7Z797	Gene names	SLC16A2, MCT8, XPCT
Domain Architecture	No domain graphic available
Description	Monocarboxylate transporter 8 (MCT 8) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter).

MTF1_MOUSE
θ value	6.88961 (rank : 311)	NC score	-0.005353 (rank : 581)
Query Neighborhood Hits	358	Target Neighborhood Hits	785	Shared Neighborhood Hits	26
SwissProt Accessions	Q07243	Gene names	Mtf1, Mtf-1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

NACAM_MOUSE
θ value	6.88961 (rank : 312)	NC score	0.093216 (rank : 258)
Query Neighborhood Hits	358	Target Neighborhood Hits	1866	Shared Neighborhood Hits	189
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PAG1_HUMAN
θ value	6.88961 (rank : 313)	NC score	0.018866 (rank : 549)
Query Neighborhood Hits	358	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

PTN23_HUMAN
θ value	6.88961 (rank : 314)	NC score	0.022106 (rank : 535)
Query Neighborhood Hits	358	Target Neighborhood Hits	646	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RBM12_HUMAN
θ value	6.88961 (rank : 315)	NC score	0.028273 (rank : 518)
Query Neighborhood Hits	358	Target Neighborhood Hits	298	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

RIMB1_HUMAN
θ value	6.88961 (rank : 316)	NC score	0.157432 (rank : 169)
Query Neighborhood Hits	358	Target Neighborhood Hits	1479	Shared Neighborhood Hits	183
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RTN4_HUMAN
θ value	6.88961 (rank : 317)	NC score	0.037345 (rank : 493)
Query Neighborhood Hits	358	Target Neighborhood Hits	357	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

RUSC2_HUMAN
θ value	6.88961 (rank : 318)	NC score	0.133116 (rank : 192)
Query Neighborhood Hits	358	Target Neighborhood Hits	205	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SMCA4_HUMAN
θ value	6.88961 (rank : 319)	NC score	0.015738 (rank : 556)
Query Neighborhood Hits	358	Target Neighborhood Hits	597	Shared Neighborhood Hits	53
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SN1L2_MOUSE
θ value	6.88961 (rank : 320)	NC score	0.024024 (rank : 529)
Query Neighborhood Hits	358	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SRRM1_MOUSE
θ value	6.88961 (rank : 321)	NC score	0.061036 (rank : 385)
Query Neighborhood Hits	358	Target Neighborhood Hits	966	Shared Neighborhood Hits	110
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	6.88961 (rank : 322)	NC score	0.053200 (rank : 439)
Query Neighborhood Hits	358	Target Neighborhood Hits	1296	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SRRM2_MOUSE
θ value	6.88961 (rank : 323)	NC score	0.052888 (rank : 443)
Query Neighborhood Hits	358	Target Neighborhood Hits	1470	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WASIP_MOUSE
θ value	6.88961 (rank : 324)	NC score	0.063047 (rank : 376)
Query Neighborhood Hits	358	Target Neighborhood Hits	392	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

WBS14_HUMAN
θ value	6.88961 (rank : 325)	NC score	0.022472 (rank : 534)
Query Neighborhood Hits	358	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

WNK1_HUMAN
θ value	6.88961 (rank : 326)	NC score	0.034043 (rank : 500)
Query Neighborhood Hits	358	Target Neighborhood Hits	1158	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ZN406_HUMAN
θ value	6.88961 (rank : 327)	NC score	-0.006308 (rank : 584)
Query Neighborhood Hits	358	Target Neighborhood Hits	794	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

APCD1_MOUSE
θ value	8.99809 (rank : 328)	NC score	0.008156 (rank : 566)
Query Neighborhood Hits	358	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U128, Q3TA99	Gene names	Apcdd1, Drapc1
Domain Architecture	No domain graphic available
Description	Protein APCDD1 precursor (Adenomatosis polyposis coli down-regulated 1 protein homolog).

BLNK_MOUSE
θ value	8.99809 (rank : 329)	NC score	0.097608 (rank : 246)
Query Neighborhood Hits	358	Target Neighborhood Hits	296	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BRD4_HUMAN
θ value	8.99809 (rank : 330)	NC score	0.039856 (rank : 482)
Query Neighborhood Hits	358	Target Neighborhood Hits	851	Shared Neighborhood Hits	80
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CIC_HUMAN
θ value	8.99809 (rank : 331)	NC score	0.046586 (rank : 465)
Query Neighborhood Hits	358	Target Neighborhood Hits	992	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CPSF7_HUMAN
θ value	8.99809 (rank : 332)	NC score	0.013954 (rank : 561)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

CPSF7_MOUSE
θ value	8.99809 (rank : 333)	NC score	0.014017 (rank : 560)
Query Neighborhood Hits	358	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BTV2, Q3TNF1, Q8BKE7, Q8CFS8	Gene names	Cpsf7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7.

CS007_HUMAN
θ value	8.99809 (rank : 334)	NC score	0.019072 (rank : 547)
Query Neighborhood Hits	358	Target Neighborhood Hits	401	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

DGKK_HUMAN
θ value	8.99809 (rank : 335)	NC score	0.038236 (rank : 488)
Query Neighborhood Hits	358	Target Neighborhood Hits	378	Shared Neighborhood Hits	45
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DLG4_HUMAN
θ value	8.99809 (rank : 336)	NC score	0.040035 (rank : 480)
Query Neighborhood Hits	358	Target Neighborhood Hits	286	Shared Neighborhood Hits	64
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

ERN2_HUMAN
θ value	8.99809 (rank : 337)	NC score	0.014724 (rank : 559)
Query Neighborhood Hits	358	Target Neighborhood Hits	844	Shared Neighborhood Hits	43
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ES8L2_HUMAN
θ value	8.99809 (rank : 338)	NC score	0.175977 (rank : 149)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	118
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FBLN2_MOUSE
θ value	8.99809 (rank : 339)	NC score	0.000485 (rank : 576)
Query Neighborhood Hits	358	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

IF35_MOUSE
θ value	8.99809 (rank : 340)	NC score	0.029741 (rank : 512)
Query Neighborhood Hits	358	Target Neighborhood Hits	210	Shared Neighborhood Hits	34
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

LPIN3_HUMAN
θ value	8.99809 (rank : 341)	NC score	0.007446 (rank : 567)
Query Neighborhood Hits	358	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

MORC4_MOUSE
θ value	8.99809 (rank : 342)	NC score	0.003510 (rank : 572)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BMD7, Q4KMM6, Q8BX95, Q9CS96	Gene names	Morc4, Zcwcc2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

MYO9B_MOUSE
θ value	8.99809 (rank : 343)	NC score	0.054926 (rank : 428)
Query Neighborhood Hits	358	Target Neighborhood Hits	311	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

OGFR_HUMAN
θ value	8.99809 (rank : 344)	NC score	0.077205 (rank : 317)
Query Neighborhood Hits	358	Target Neighborhood Hits	1582	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OGFR_MOUSE
θ value	8.99809 (rank : 345)	NC score	0.041410 (rank : 474)
Query Neighborhood Hits	358	Target Neighborhood Hits	584	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PI3R4_MOUSE
θ value	8.99809 (rank : 346)	NC score	0.002404 (rank : 573)
Query Neighborhood Hits	358	Target Neighborhood Hits	535	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PTK6_HUMAN
θ value	8.99809 (rank : 347)	NC score	0.106835 (rank : 222)
Query Neighborhood Hits	358	Target Neighborhood Hits	1020	Shared Neighborhood Hits	154
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RECQ5_HUMAN
θ value	8.99809 (rank : 348)	NC score	0.017398 (rank : 553)
Query Neighborhood Hits	358	Target Neighborhood Hits	390	Shared Neighborhood Hits	55
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SEPT9_HUMAN
θ value	8.99809 (rank : 349)	NC score	0.040170 (rank : 478)
Query Neighborhood Hits	358	Target Neighborhood Hits	706	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SFPQ_MOUSE
θ value	8.99809 (rank : 350)	NC score	0.037539 (rank : 491)
Query Neighborhood Hits	358	Target Neighborhood Hits	958	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SREC2_HUMAN
θ value	8.99809 (rank : 351)	NC score	0.005230 (rank : 568)
Query Neighborhood Hits	358	Target Neighborhood Hits	645	Shared Neighborhood Hits	31
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

STS2_HUMAN
θ value	8.99809 (rank : 352)	NC score	0.174821 (rank : 151)
Query Neighborhood Hits	358	Target Neighborhood Hits	108	Shared Neighborhood Hits	76
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SV2B_MOUSE
θ value	8.99809 (rank : 353)	NC score	0.019111 (rank : 546)
Query Neighborhood Hits	358	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

SYNJ2_MOUSE
θ value	8.99809 (rank : 354)	NC score	0.016338 (rank : 554)
Query Neighborhood Hits	358	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

TACC2_HUMAN
θ value	8.99809 (rank : 355)	NC score	0.031251 (rank : 508)
Query Neighborhood Hits	358	Target Neighborhood Hits	856	Shared Neighborhood Hits	67
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TESK2_HUMAN
θ value	8.99809 (rank : 356)	NC score	0.033186 (rank : 505)
Query Neighborhood Hits	358	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TM1L1_MOUSE
θ value	8.99809 (rank : 357)	NC score	0.044068 (rank : 470)
Query Neighborhood Hits	358	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q923U0, Q99KE0, Q9D6Y5	Gene names	Tom1l1, Srcasm
Domain Architecture
Description	TOM1-like 1 protein (Target of myb-like 1 protein) (Src-activating and signaling molecule protein).

ZN688_HUMAN
θ value	8.99809 (rank : 358)	NC score	-0.004420 (rank : 579)
Query Neighborhood Hits	358	Target Neighborhood Hits	873	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

3BP1_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.087278 (rank : 279)
Query Neighborhood Hits	358	Target Neighborhood Hits	376	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABL1_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.103024 (rank : 230)
Query Neighborhood Hits	358	Target Neighborhood Hits	1220	Shared Neighborhood Hits	153
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.104566 (rank : 226)
Query Neighborhood Hits	358	Target Neighborhood Hits	1178	Shared Neighborhood Hits	156
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.098355 (rank : 244)
Query Neighborhood Hits	358	Target Neighborhood Hits	1045	Shared Neighborhood Hits	129
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.087376 (rank : 278)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACK1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.063825 (rank : 372)
Query Neighborhood Hits	358	Target Neighborhood Hits	1140	Shared Neighborhood Hits	138
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.063390 (rank : 373)
Query Neighborhood Hits	358	Target Neighborhood Hits	1080	Shared Neighborhood Hits	128
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

APS_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.096257 (rank : 252)
Query Neighborhood Hits	358	Target Neighborhood Hits	162	Shared Neighborhood Hits	43
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.073174 (rank : 329)
Query Neighborhood Hits	358	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.090065 (rank : 266)
Query Neighborhood Hits	358	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.079423 (rank : 302)
Query Neighborhood Hits	358	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.072968 (rank : 331)
Query Neighborhood Hits	358	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.071638 (rank : 336)
Query Neighborhood Hits	358	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.121126 (rank : 201)
Query Neighborhood Hits	358	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.120882 (rank : 205)
Query Neighborhood Hits	358	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.175443 (rank : 150)
Query Neighborhood Hits	358	Target Neighborhood Hits	172	Shared Neighborhood Hits	80
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.110672 (rank : 217)
Query Neighborhood Hits	358	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.117097 (rank : 211)
Query Neighborhood Hits	358	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.097947 (rank : 245)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	21
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.104866 (rank : 225)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.088042 (rank : 275)
Query Neighborhood Hits	358	Target Neighborhood Hits	375	Shared Neighborhood Hits	29
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.090046 (rank : 267)
Query Neighborhood Hits	358	Target Neighborhood Hits	351	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.089513 (rank : 270)
Query Neighborhood Hits	358	Target Neighborhood Hits	344	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.076433 (rank : 319)
Query Neighborhood Hits	358	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.119086 (rank : 208)
Query Neighborhood Hits	358	Target Neighborhood Hits	129	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.135498 (rank : 189)
Query Neighborhood Hits	358	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BAIP2_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.093791 (rank : 256)
Query Neighborhood Hits	358	Target Neighborhood Hits	192	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.096114 (rank : 254)
Query Neighborhood Hits	358	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.064298 (rank : 368)
Query Neighborhood Hits	358	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.064530 (rank : 366)
Query Neighborhood Hits	358	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCL9_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.057387 (rank : 412)
Query Neighborhood Hits	358	Target Neighborhood Hits	1008	Shared Neighborhood Hits	124
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCR_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.097508 (rank : 247)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.110036 (rank : 218)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.091014 (rank : 264)
Query Neighborhood Hits	358	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.151123 (rank : 173)
Query Neighborhood Hits	358	Target Neighborhood Hits	335	Shared Neighborhood Hits	96
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.149073 (rank : 177)
Query Neighborhood Hits	358	Target Neighborhood Hits	283	Shared Neighborhood Hits	93
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.115911 (rank : 213)
Query Neighborhood Hits	358	Target Neighborhood Hits	994	Shared Neighborhood Hits	138
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.111367 (rank : 216)
Query Neighborhood Hits	358	Target Neighborhood Hits	992	Shared Neighborhood Hits	128
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMX_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.062602 (rank : 379)
Query Neighborhood Hits	358	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.062931 (rank : 377)
Query Neighborhood Hits	358	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BSN_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.055522 (rank : 424)
Query Neighborhood Hits	358	Target Neighborhood Hits	2057	Shared Neighborhood Hits	156
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CHIN_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.098443 (rank : 243)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.099461 (rank : 240)
Query Neighborhood Hits	358	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.096968 (rank : 249)
Query Neighborhood Hits	358	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.068297 (rank : 349)
Query Neighborhood Hits	358	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.155743 (rank : 171)
Query Neighborhood Hits	358	Target Neighborhood Hits	374	Shared Neighborhood Hits	74
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CK024_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.054332 (rank : 431)
Query Neighborhood Hits	358	Target Neighborhood Hits	408	Shared Neighborhood Hits	78
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CN155_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.075862 (rank : 321)
Query Neighborhood Hits	358	Target Neighborhood Hits	385	Shared Neighborhood Hits	59
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

DAPP1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.118345 (rank : 210)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.118890 (rank : 209)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DOCK3_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.056285 (rank : 419)
Query Neighborhood Hits	358	Target Neighborhood Hits	87	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.060283 (rank : 391)
Query Neighborhood Hits	358	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DREB_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.082797 (rank : 288)
Query Neighborhood Hits	358	Target Neighborhood Hits	450	Shared Neighborhood Hits	38
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.086361 (rank : 281)
Query Neighborhood Hits	358	Target Neighborhood Hits	446	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ECT2_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.092936 (rank : 259)
Query Neighborhood Hits	358	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.096211 (rank : 253)
Query Neighborhood Hits	358	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.084422 (rank : 285)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.081472 (rank : 295)
Query Neighborhood Hits	358	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EPS8_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.155524 (rank : 172)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.151024 (rank : 174)
Query Neighborhood Hits	358	Target Neighborhood Hits	162	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.142131 (rank : 183)
Query Neighborhood Hits	358	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.164087 (rank : 160)
Query Neighborhood Hits	358	Target Neighborhood Hits	169	Shared Neighborhood Hits	111
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.195835 (rank : 144)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.215561 (rank : 139)
Query Neighborhood Hits	358	Target Neighborhood Hits	168	Shared Neighborhood Hits	131
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FA47A_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.056278 (rank : 420)
Query Neighborhood Hits	358	Target Neighborhood Hits	451	Shared Neighborhood Hits	83
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FA47B_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.059705 (rank : 400)
Query Neighborhood Hits	358	Target Neighborhood Hits	431	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FARP1_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.058648 (rank : 406)
Query Neighborhood Hits	358	Target Neighborhood Hits	241	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.059547 (rank : 403)
Query Neighborhood Hits	358	Target Neighborhood Hits	240	Shared Neighborhood Hits	33
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.064076 (rank : 371)
Query Neighborhood Hits	358	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.066583 (rank : 355)
Query Neighborhood Hits	358	Target Neighborhood Hits	1278	Shared Neighborhood Hits	86
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.050643 (rank : 454)
Query Neighborhood Hits	358	Target Neighborhood Hits	978	Shared Neighborhood Hits	60
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.073066 (rank : 330)
Query Neighborhood Hits	358	Target Neighborhood Hits	367	Shared Neighborhood Hits	54
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.070072 (rank : 341)
Query Neighborhood Hits	358	Target Neighborhood Hits	387	Shared Neighborhood Hits	54
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.073633 (rank : 328)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.070352 (rank : 340)
Query Neighborhood Hits	358	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.074323 (rank : 327)
Query Neighborhood Hits	358	Target Neighborhood Hits	249	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.080445 (rank : 300)
Query Neighborhood Hits	358	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.077883 (rank : 312)
Query Neighborhood Hits	358	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.078384 (rank : 308)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.055116 (rank : 427)
Query Neighborhood Hits	358	Target Neighborhood Hits	237	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.062089 (rank : 380)
Query Neighborhood Hits	358	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FUT8_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.081073 (rank : 298)
Query Neighborhood Hits	358	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.065570 (rank : 361)
Query Neighborhood Hits	358	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GNRP_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.072935 (rank : 332)
Query Neighborhood Hits	358	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.082640 (rank : 290)
Query Neighborhood Hits	358	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.081162 (rank : 297)
Query Neighborhood Hits	358	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.082819 (rank : 287)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.101887 (rank : 234)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.102863 (rank : 231)
Query Neighborhood Hits	358	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.082169 (rank : 294)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.092801 (rank : 261)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GSCR1_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.055993 (rank : 421)
Query Neighborhood Hits	358	Target Neighborhood Hits	674	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HAPIP_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.082794 (rank : 289)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HGS_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.052018 (rank : 447)
Query Neighborhood Hits	358	Target Neighborhood Hits	517	Shared Neighborhood Hits	45
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.053920 (rank : 434)
Query Neighborhood Hits	358	Target Neighborhood Hits	589	Shared Neighborhood Hits	58
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.088887 (rank : 272)
Query Neighborhood Hits	358	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.059977 (rank : 397)
Query Neighborhood Hits	358	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.055316 (rank : 425)
Query Neighborhood Hits	358	Target Neighborhood Hits	857	Shared Neighborhood Hits	53
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.055262 (rank : 426)
Query Neighborhood Hits	358	Target Neighborhood Hits	848	Shared Neighborhood Hits	53
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.055569 (rank : 423)
Query Neighborhood Hits	358	Target Neighborhood Hits	858	Shared Neighborhood Hits	53
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

JIP1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.078276 (rank : 309)
Query Neighborhood Hits	358	Target Neighborhood Hits	271	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.076691 (rank : 318)
Query Neighborhood Hits	358	Target Neighborhood Hits	259	Shared Neighborhood Hits	77
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.085326 (rank : 284)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	73
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.078911 (rank : 305)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K1802_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.050216 (rank : 457)
Query Neighborhood Hits	358	Target Neighborhood Hits	1596	Shared Neighborhood Hits	145
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

KSYK_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.060144 (rank : 396)
Query Neighborhood Hits	358	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.061563 (rank : 383)
Query Neighborhood Hits	358	Target Neighborhood Hits	944	Shared Neighborhood Hits	71
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.077251 (rank : 316)
Query Neighborhood Hits	358	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.107675 (rank : 221)
Query Neighborhood Hits	358	Target Neighborhood Hits	987	Shared Neighborhood Hits	115
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.106658 (rank : 224)
Query Neighborhood Hits	358	Target Neighborhood Hits	981	Shared Neighborhood Hits	113
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.119163 (rank : 206)
Query Neighborhood Hits	358	Target Neighborhood Hits	531	Shared Neighborhood Hits	122
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.088856 (rank : 273)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.086119 (rank : 282)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.085476 (rank : 283)
Query Neighborhood Hits	358	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MAGE1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.059656 (rank : 402)
Query Neighborhood Hits	358	Target Neighborhood Hits	1389	Shared Neighborhood Hits	141
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MATK_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.074652 (rank : 325)
Query Neighborhood Hits	358	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.075496 (rank : 322)
Query Neighborhood Hits	358	Target Neighborhood Hits	952	Shared Neighborhood Hits	87
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.124092 (rank : 198)
Query Neighborhood Hits	358	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.101792 (rank : 235)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MLL3_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.064220 (rank : 370)
Query Neighborhood Hits	358	Target Neighborhood Hits	1644	Shared Neighborhood Hits	153
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.055661 (rank : 422)
Query Neighborhood Hits	358	Target Neighborhood Hits	1399	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MPP5_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.053862 (rank : 437)
Query Neighborhood Hits	358	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.053004 (rank : 442)
Query Neighborhood Hits	358	Target Neighborhood Hits	226	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.069998 (rank : 342)
Query Neighborhood Hits	358	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.066793 (rank : 353)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUC1_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.068312 (rank : 348)
Query Neighborhood Hits	358	Target Neighborhood Hits	975	Shared Neighborhood Hits	124
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MYO15_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.053128 (rank : 440)
Query Neighborhood Hits	358	Target Neighborhood Hits	671	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO15_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.052467 (rank : 445)
Query Neighborhood Hits	358	Target Neighborhood Hits	467	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO9B_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.059771 (rank : 398)
Query Neighborhood Hits	358	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NCOA6_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.072043 (rank : 334)
Query Neighborhood Hits	358	Target Neighborhood Hits	1202	Shared Neighborhood Hits	142
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCOA6_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.060148 (rank : 395)
Query Neighborhood Hits	358	Target Neighborhood Hits	1076	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.159150 (rank : 168)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.160500 (rank : 167)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NRAP_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.059350 (rank : 405)
Query Neighborhood Hits	358	Target Neighborhood Hits	159	Shared Neighborhood Hits	9
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.060222 (rank : 392)
Query Neighborhood Hits	358	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

OPHN1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.060291 (rank : 390)
Query Neighborhood Hits	358	Target Neighborhood Hits	161	Shared Neighborhood Hits	22
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.056965 (rank : 415)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.101935 (rank : 233)
Query Neighborhood Hits	358	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.099945 (rank : 237)
Query Neighborhood Hits	358	Target Neighborhood Hits	401	Shared Neighborhood Hits	52
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.157296 (rank : 170)
Query Neighborhood Hits	358	Target Neighborhood Hits	479	Shared Neighborhood Hits	104
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.166493 (rank : 156)
Query Neighborhood Hits	358	Target Neighborhood Hits	435	Shared Neighborhood Hits	108
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.119162 (rank : 207)
Query Neighborhood Hits	358	Target Neighborhood Hits	519	Shared Neighborhood Hits	76
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCLO_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.065886 (rank : 359)
Query Neighborhood Hits	358	Target Neighborhood Hits	2046	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.056716 (rank : 417)
Query Neighborhood Hits	358	Target Neighborhood Hits	2275	Shared Neighborhood Hits	180
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PKHG1_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.133236 (rank : 191)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.060795 (rank : 386)
Query Neighborhood Hits	358	Target Neighborhood Hits	200	Shared Neighborhood Hits	24
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.099576 (rank : 239)
Query Neighborhood Hits	358	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.087743 (rank : 276)
Query Neighborhood Hits	358	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.126158 (rank : 197)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP2_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.052140 (rank : 446)
Query Neighborhood Hits	358	Target Neighborhood Hits	347	Shared Neighborhood Hits	42
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRRT3_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.076271 (rank : 320)
Query Neighborhood Hits	358	Target Neighborhood Hits	998	Shared Neighborhood Hits	139
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTK6_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.108588 (rank : 219)
Query Neighborhood Hits	358	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.077599 (rank : 315)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.077608 (rank : 314)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.066483 (rank : 356)
Query Neighborhood Hits	358	Target Neighborhood Hits	234	Shared Neighborhood Hits	49
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.067711 (rank : 350)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.132523 (rank : 193)
Query Neighborhood Hits	358	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS2_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.057848 (rank : 410)
Query Neighborhood Hits	358	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.053912 (rank : 435)
Query Neighborhood Hits	358	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.080052 (rank : 301)
Query Neighborhood Hits	358	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.078578 (rank : 307)
Query Neighborhood Hits	358	Target Neighborhood Hits	186	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.074861 (rank : 324)
Query Neighborhood Hits	358	Target Neighborhood Hits	190	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.077719 (rank : 313)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.054350 (rank : 430)
Query Neighborhood Hits	358	Target Neighborhood Hits	550	Shared Neighborhood Hits	32
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RIMB2_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.265394 (rank : 125)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	114
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.257707 (rank : 127)
Query Neighborhood Hits	358	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SAMN1_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.071426 (rank : 337)
Query Neighborhood Hits	358	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.066967 (rank : 352)
Query Neighborhood Hits	358	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.082634 (rank : 291)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	78
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SELPL_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.056534 (rank : 418)
Query Neighborhood Hits	358	Target Neighborhood Hits	588	Shared Neighborhood Hits	95
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SH21A_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.082192 (rank : 293)
Query Neighborhood Hits	358	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.081337 (rank : 296)
Query Neighborhood Hits	358	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.102277 (rank : 232)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.103719 (rank : 228)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.070874 (rank : 339)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.083828 (rank : 286)
Query Neighborhood Hits	358	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.060173 (rank : 393)
Query Neighborhood Hits	358	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.074574 (rank : 326)
Query Neighborhood Hits	358	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.051095 (rank : 451)
Query Neighborhood Hits	358	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.071244 (rank : 338)
Query Neighborhood Hits	358	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.069939 (rank : 343)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.094211 (rank : 255)
Query Neighborhood Hits	358	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.096560 (rank : 251)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.092838 (rank : 260)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.093756 (rank : 257)
Query Neighborhood Hits	358	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.090407 (rank : 265)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.089606 (rank : 269)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.089692 (rank : 268)
Query Neighborhood Hits	358	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.096590 (rank : 250)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	48
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.089237 (rank : 271)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	50
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.087649 (rank : 277)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.098557 (rank : 242)
Query Neighborhood Hits	358	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.099941 (rank : 238)
Query Neighborhood Hits	358	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB2_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.242121 (rank : 132)
Query Neighborhood Hits	358	Target Neighborhood Hits	86	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.243873 (rank : 131)
Query Neighborhood Hits	358	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.150351 (rank : 176)
Query Neighborhood Hits	358	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.148218 (rank : 178)
Query Neighborhood Hits	358	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.163517 (rank : 161)
Query Neighborhood Hits	358	Target Neighborhood Hits	139	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.164467 (rank : 159)
Query Neighborhood Hits	358	Target Neighborhood Hits	136	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.106749 (rank : 223)
Query Neighborhood Hits	358	Target Neighborhood Hits	81	Shared Neighborhood Hits	53
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.122469 (rank : 199)
Query Neighborhood Hits	358	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.202119 (rank : 141)
Query Neighborhood Hits	358	Target Neighborhood Hits	148	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.179246 (rank : 147)
Query Neighborhood Hits	358	Target Neighborhood Hits	141	Shared Neighborhood Hits	82
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOCS6_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.050968 (rank : 452)
Query Neighborhood Hits	358	Target Neighborhood Hits	126	Shared Neighborhood Hits	32
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.050955 (rank : 453)
Query Neighborhood Hits	358	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.062744 (rank : 378)
Query Neighborhood Hits	358	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SON_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.091102 (rank : 263)
Query Neighborhood Hits	358	Target Neighborhood Hits	1568	Shared Neighborhood Hits	169
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SOS1_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.065031 (rank : 362)
Query Neighborhood Hits	358	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.064508 (rank : 367)
Query Neighborhood Hits	358	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.183864 (rank : 145)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.160752 (rank : 166)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.077947 (rank : 311)
Query Neighborhood Hits	358	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.087016 (rank : 280)
Query Neighborhood Hits	358	Target Neighborhood Hits	964	Shared Neighborhood Hits	107
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM1_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.051774 (rank : 449)
Query Neighborhood Hits	358	Target Neighborhood Hits	690	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

STS1_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.136403 (rank : 187)
Query Neighborhood Hits	358	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.140495 (rank : 184)
Query Neighborhood Hits	358	Target Neighborhood Hits	104	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TARSH_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.078646 (rank : 306)
Query Neighborhood Hits	358	Target Neighborhood Hits	768	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TENS4_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.050540 (rank : 455)
Query Neighborhood Hits	358	Target Neighborhood Hits	214	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.053883 (rank : 436)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.057855 (rank : 409)
Query Neighborhood Hits	358	Target Neighborhood Hits	1103	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.057054 (rank : 414)
Query Neighborhood Hits	358	Target Neighborhood Hits	1333	Shared Neighborhood Hits	72
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.120942 (rank : 204)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.122006 (rank : 200)
Query Neighborhood Hits	358	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRIO_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.060755 (rank : 387)
Query Neighborhood Hits	358	Target Neighborhood Hits	1580	Shared Neighborhood Hits	108
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXK_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.103599 (rank : 229)
Query Neighborhood Hits	358	Target Neighborhood Hits	971	Shared Neighborhood Hits	122
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXND2_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.051894 (rank : 448)
Query Neighborhood Hits	358	Target Neighborhood Hits	793	Shared Neighborhood Hits	86
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ZAP70_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.060723 (rank : 388)
Query Neighborhood Hits	358	Target Neighborhood Hits	893	Shared Neighborhood Hits	63
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.061463 (rank : 384)
Query Neighborhood Hits	358	Target Neighborhood Hits	905	Shared Neighborhood Hits	64
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

HCLS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	358	Target Neighborhood Hits	358	Shared Neighborhood Hits	358
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
NC score	0.965799 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	358	Target Neighborhood Hits	329	Shared Neighborhood Hits	221
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_MOUSE
NC score	0.934019 (rank : 3)	θ value	1.87955e-106 (rank : 3)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	177
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.930814 (rank : 4)	θ value	4.49445e-92 (rank : 4)
Query Neighborhood Hits	358	Target Neighborhood Hits	269	Shared Neighborhood Hits	177
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DBNL_HUMAN
NC score	0.694494 (rank : 5)	θ value	1.058e-16 (rank : 5)
Query Neighborhood Hits	358	Target Neighborhood Hits	244	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.687107 (rank : 6)	θ value	2.60593e-15 (rank : 6)
Query Neighborhood Hits	358	Target Neighborhood Hits	306	Shared Neighborhood Hits	158
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SH3K1_MOUSE
NC score	0.656580 (rank : 7)	θ value	5.26297e-08 (rank : 14)
Query Neighborhood Hits	358	Target Neighborhood Hits	332	Shared Neighborhood Hits	171
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.654548 (rank : 8)	θ value	6.87365e-08 (rank : 16)
Query Neighborhood Hits	358	Target Neighborhood Hits	341	Shared Neighborhood Hits	167
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_MOUSE
NC score	0.651735 (rank : 9)	θ value	1.53129e-07 (rank : 18)
Query Neighborhood Hits	358	Target Neighborhood Hits	336	Shared Neighborhood Hits	185
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.638004 (rank : 10)	θ value	1.69304e-06 (rank : 33)
Query Neighborhood Hits	358	Target Neighborhood Hits	315	Shared Neighborhood Hits	173
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ABI2_MOUSE
NC score	0.623518 (rank : 11)	θ value	1.69304e-06 (rank : 32)
Query Neighborhood Hits	358	Target Neighborhood Hits	266	Shared Neighborhood Hits	169
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.620595 (rank : 12)	θ value	1.69304e-06 (rank : 31)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	179
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NCF2_HUMAN
NC score	0.618350 (rank : 13)	θ value	0.000786445 (rank : 93)
Query Neighborhood Hits	358	Target Neighborhood Hits	229	Shared Neighborhood Hits	153
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G2_HUMAN
NC score	0.616356 (rank : 14)	θ value	3.64472e-09 (rank : 9)
Query Neighborhood Hits	358	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
NC score	0.615291 (rank : 15)	θ value	5.81887e-07 (rank : 27)
Query Neighborhood Hits	358	Target Neighborhood Hits	236	Shared Neighborhood Hits	162
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_MOUSE
NC score	0.610777 (rank : 16)	θ value	1.69304e-06 (rank : 30)
Query Neighborhood Hits	358	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

VINEX_HUMAN
NC score	0.610169 (rank : 17)	θ value	2.44474e-05 (rank : 58)
Query Neighborhood Hits	358	Target Neighborhood Hits	270	Shared Neighborhood Hits	175
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.609126 (rank : 18)	θ value	1.09739e-05 (rank : 48)
Query Neighborhood Hits	358	Target Neighborhood Hits	286	Shared Neighborhood Hits	178
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SH3G2_MOUSE
NC score	0.607874 (rank : 19)	θ value	6.87365e-08 (rank : 15)
Query Neighborhood Hits	358	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
NC score	0.606602 (rank : 20)	θ value	1.99992e-07 (rank : 23)
Query Neighborhood Hits	358	Target Neighborhood Hits	222	Shared Neighborhood Hits	158
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ABI1_HUMAN
NC score	0.592114 (rank : 21)	θ value	2.21117e-06 (rank : 34)
Query Neighborhood Hits	358	Target Neighborhood Hits	257	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G1_MOUSE
NC score	0.589732 (rank : 22)	θ value	1.99992e-07 (rank : 22)
Query Neighborhood Hits	358	Target Neighborhood Hits	291	Shared Neighborhood Hits	166
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

PACN2_HUMAN
NC score	0.588277 (rank : 23)	θ value	2.36244e-08 (rank : 12)
Query Neighborhood Hits	358	Target Neighborhood Hits	339	Shared Neighborhood Hits	166
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.587919 (rank : 24)	θ value	4.0297e-08 (rank : 13)
Query Neighborhood Hits	358	Target Neighborhood Hits	382	Shared Neighborhood Hits	168
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G1_HUMAN
NC score	0.585316 (rank : 25)	θ value	7.59969e-07 (rank : 29)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SRBS1_MOUSE
NC score	0.582156 (rank : 26)	θ value	0.00020696 (rank : 79)
Query Neighborhood Hits	358	Target Neighborhood Hits	409	Shared Neighborhood Hits	191
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN1_MOUSE
NC score	0.578538 (rank : 27)	θ value	8.97725e-08 (rank : 17)
Query Neighborhood Hits	358	Target Neighborhood Hits	283	Shared Neighborhood Hits	165
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAC_HUMAN
NC score	0.576812 (rank : 28)	θ value	2.21117e-06 (rank : 37)
Query Neighborhood Hits	358	Target Neighborhood Hits	276	Shared Neighborhood Hits	162
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.575459 (rank : 29)	θ value	0.00020696 (rank : 78)
Query Neighborhood Hits	358	Target Neighborhood Hits	396	Shared Neighborhood Hits	180
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN1_HUMAN
NC score	0.573202 (rank : 30)	θ value	1.53129e-07 (rank : 21)
Query Neighborhood Hits	358	Target Neighborhood Hits	320	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAM1_HUMAN
NC score	0.572088 (rank : 31)	θ value	3.77169e-06 (rank : 40)
Query Neighborhood Hits	358	Target Neighborhood Hits	271	Shared Neighborhood Hits	174
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_MOUSE
NC score	0.569616 (rank : 32)	θ value	9.29e-05 (rank : 69)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	141
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_MOUSE
NC score	0.569330 (rank : 33)	θ value	6.43352e-06 (rank : 41)
Query Neighborhood Hits	358	Target Neighborhood Hits	273	Shared Neighborhood Hits	174
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_MOUSE
NC score	0.565116 (rank : 34)	θ value	5.81887e-07 (rank : 26)
Query Neighborhood Hits	358	Target Neighborhood Hits	297	Shared Neighborhood Hits	176
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

STAC_MOUSE
NC score	0.561435 (rank : 35)	θ value	8.40245e-06 (rank : 43)
Query Neighborhood Hits	358	Target Neighborhood Hits	268	Shared Neighborhood Hits	160
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP2_HUMAN
NC score	0.560993 (rank : 36)	θ value	4.45536e-07 (rank : 25)
Query Neighborhood Hits	358	Target Neighborhood Hits	304	Shared Neighborhood Hits	176
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_HUMAN
NC score	0.555754 (rank : 37)	θ value	2.21117e-06 (rank : 35)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.555468 (rank : 38)	θ value	2.21117e-06 (rank : 36)
Query Neighborhood Hits	358	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAM2_MOUSE
NC score	0.552341 (rank : 39)	θ value	2.44474e-05 (rank : 57)
Query Neighborhood Hits	358	Target Neighborhood Hits	285	Shared Neighborhood Hits	169
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

NCF4_HUMAN
NC score	0.545811 (rank : 40)	θ value	0.000270298 (rank : 81)
Query Neighborhood Hits	358	Target Neighborhood Hits	161	Shared Neighborhood Hits	131
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PACN3_MOUSE
NC score	0.543971 (rank : 41)	θ value	2.88788e-06 (rank : 39)
Query Neighborhood Hits	358	Target Neighborhood Hits	380	Shared Neighborhood Hits	159
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

STAM2_HUMAN
NC score	0.541081 (rank : 42)	θ value	3.19293e-05 (rank : 62)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	171
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

PACN3_HUMAN
NC score	0.537200 (rank : 43)	θ value	8.40245e-06 (rank : 42)
Query Neighborhood Hits	358	Target Neighborhood Hits	385	Shared Neighborhood Hits	156
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

NCK2_HUMAN
NC score	0.536774 (rank : 44)	θ value	2.88788e-06 (rank : 38)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.536445 (rank : 45)	θ value	3.19293e-05 (rank : 61)
Query Neighborhood Hits	358	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

LASP1_HUMAN
NC score	0.535480 (rank : 46)	θ value	1.09739e-05 (rank : 44)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	148
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PPIP1_MOUSE
NC score	0.535414 (rank : 47)	θ value	0.00035302 (rank : 83)
Query Neighborhood Hits	358	Target Neighborhood Hits	377	Shared Neighborhood Hits	173
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

LASP1_MOUSE
NC score	0.531101 (rank : 48)	θ value	1.09739e-05 (rank : 45)
Query Neighborhood Hits	358	Target Neighborhood Hits	297	Shared Neighborhood Hits	148
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

GRAP_HUMAN
NC score	0.530614 (rank : 49)	θ value	2.44474e-05 (rank : 54)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	178
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.529729 (rank : 50)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	358	Target Neighborhood Hits	309	Shared Neighborhood Hits	176
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ABI3_MOUSE
NC score	0.525623 (rank : 51)	θ value	0.0113563 (rank : 117)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PPIP1_HUMAN
NC score	0.525162 (rank : 52)	θ value	0.00175202 (rank : 102)
Query Neighborhood Hits	358	Target Neighborhood Hits	389	Shared Neighborhood Hits	173
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ARHG7_MOUSE
NC score	0.522223 (rank : 53)	θ value	2.44474e-05 (rank : 53)
Query Neighborhood Hits	358	Target Neighborhood Hits	396	Shared Neighborhood Hits	173
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

STAC3_MOUSE
NC score	0.520986 (rank : 54)	θ value	9.29e-05 (rank : 71)
Query Neighborhood Hits	358	Target Neighborhood Hits	232	Shared Neighborhood Hits	145
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.520134 (rank : 55)	θ value	9.29e-05 (rank : 70)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG7_HUMAN
NC score	0.519037 (rank : 56)	θ value	1.43324e-05 (rank : 49)
Query Neighborhood Hits	358	Target Neighborhood Hits	347	Shared Neighborhood Hits	171
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ABI3_HUMAN
NC score	0.515356 (rank : 57)	θ value	0.0252991 (rank : 127)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	140
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CT032_HUMAN
NC score	0.500352 (rank : 58)	θ value	3.19293e-05 (rank : 60)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DNMBP_HUMAN
NC score	0.498401 (rank : 59)	θ value	0.000786445 (rank : 92)
Query Neighborhood Hits	358	Target Neighborhood Hits	413	Shared Neighborhood Hits	184
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.491608 (rank : 60)	θ value	0.00134147 (rank : 95)
Query Neighborhood Hits	358	Target Neighborhood Hits	435	Shared Neighborhood Hits	191
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_MOUSE
NC score	0.488111 (rank : 61)	θ value	0.000786445 (rank : 91)
Query Neighborhood Hits	358	Target Neighborhood Hits	394	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG6_HUMAN
NC score	0.483962 (rank : 62)	θ value	0.000786445 (rank : 90)
Query Neighborhood Hits	358	Target Neighborhood Hits	376	Shared Neighborhood Hits	165
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NEBL_HUMAN
NC score	0.477255 (rank : 63)	θ value	1.43324e-05 (rank : 50)
Query Neighborhood Hits	358	Target Neighborhood Hits	457	Shared Neighborhood Hits	152
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

OSTF1_HUMAN
NC score	0.475894 (rank : 64)	θ value	1.09739e-05 (rank : 46)
Query Neighborhood Hits	358	Target Neighborhood Hits	466	Shared Neighborhood Hits	174
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.474392 (rank : 65)	θ value	7.59969e-07 (rank : 28)
Query Neighborhood Hits	358	Target Neighborhood Hits	467	Shared Neighborhood Hits	175
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CRKL_HUMAN
NC score	0.473869 (rank : 66)	θ value	0.00665767 (rank : 111)
Query Neighborhood Hits	358	Target Neighborhood Hits	313	Shared Neighborhood Hits	170
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NCF1_MOUSE
NC score	0.470347 (rank : 67)	θ value	0.365318 (rank : 176)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	149
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.469392 (rank : 68)	θ value	0.21417 (rank : 165)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	144
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

BCAR1_HUMAN
NC score	0.465190 (rank : 69)	θ value	1.87187e-05 (rank : 52)
Query Neighborhood Hits	358	Target Neighborhood Hits	554	Shared Neighborhood Hits	220
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRKL_MOUSE
NC score	0.463729 (rank : 70)	θ value	0.0113563 (rank : 118)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	163
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

BCAR1_MOUSE
NC score	0.463584 (rank : 71)	θ value	7.1131e-05 (rank : 68)
Query Neighborhood Hits	358	Target Neighborhood Hits	438	Shared Neighborhood Hits	201
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

VAV_MOUSE
NC score	0.445256 (rank : 72)	θ value	9.29e-05 (rank : 73)
Query Neighborhood Hits	358	Target Neighborhood Hits	430	Shared Neighborhood Hits	163
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.444201 (rank : 73)	θ value	9.29e-05 (rank : 72)
Query Neighborhood Hits	358	Target Neighborhood Hits	452	Shared Neighborhood Hits	166
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CRK_MOUSE
NC score	0.442759 (rank : 74)	θ value	0.21417 (rank : 160)
Query Neighborhood Hits	358	Target Neighborhood Hits	314	Shared Neighborhood Hits	165
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.436226 (rank : 75)	θ value	0.21417 (rank : 159)
Query Neighborhood Hits	358	Target Neighborhood Hits	308	Shared Neighborhood Hits	163
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEBU_HUMAN
NC score	0.431439 (rank : 76)	θ value	2.44474e-05 (rank : 56)
Query Neighborhood Hits	358	Target Neighborhood Hits	420	Shared Neighborhood Hits	156
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CASL_MOUSE
NC score	0.430609 (rank : 77)	θ value	3.19293e-05 (rank : 59)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	148
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.428256 (rank : 78)	θ value	5.44631e-05 (rank : 64)
Query Neighborhood Hits	358	Target Neighborhood Hits	259	Shared Neighborhood Hits	154
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NPHP1_MOUSE
NC score	0.428146 (rank : 79)	θ value	0.0736092 (rank : 142)
Query Neighborhood Hits	358	Target Neighborhood Hits	267	Shared Neighborhood Hits	154
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

EFS_MOUSE
NC score	0.420400 (rank : 80)	θ value	0.00869519 (rank : 114)
Query Neighborhood Hits	358	Target Neighborhood Hits	389	Shared Neighborhood Hits	180
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN2_HUMAN
NC score	0.420197 (rank : 81)	θ value	1.53129e-07 (rank : 19)
Query Neighborhood Hits	358	Target Neighborhood Hits	1173	Shared Neighborhood Hits	193
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV2_MOUSE
NC score	0.417717 (rank : 82)	θ value	0.00035302 (rank : 85)
Query Neighborhood Hits	358	Target Neighborhood Hits	456	Shared Neighborhood Hits	166
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.416767 (rank : 83)	θ value	0.00035302 (rank : 84)
Query Neighborhood Hits	358	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

EFS_HUMAN
NC score	0.414121 (rank : 84)	θ value	0.00869519 (rank : 113)
Query Neighborhood Hits	358	Target Neighborhood Hits	348	Shared Neighborhood Hits	170
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

PLCG1_MOUSE
NC score	0.407975 (rank : 85)	θ value	1.09739e-05 (rank : 47)
Query Neighborhood Hits	358	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

AHI1_HUMAN
NC score	0.406967 (rank : 86)	θ value	0.000602161 (rank : 88)
Query Neighborhood Hits	358	Target Neighborhood Hits	537	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.406059 (rank : 87)	θ value	0.000602161 (rank : 89)
Query Neighborhood Hits	358	Target Neighborhood Hits	496	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ITSN1_HUMAN
NC score	0.404291 (rank : 88)	θ value	2.79066e-09 (rank : 8)
Query Neighborhood Hits	358	Target Neighborhood Hits	1757	Shared Neighborhood Hits	236
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.404046 (rank : 89)	θ value	9.59137e-10 (rank : 7)
Query Neighborhood Hits	358	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
NC score	0.400861 (rank : 90)	θ value	2.61198e-07 (rank : 24)
Query Neighborhood Hits	358	Target Neighborhood Hits	1371	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV3_HUMAN
NC score	0.395911 (rank : 91)	θ value	0.000270298 (rank : 82)
Query Neighborhood Hits	358	Target Neighborhood Hits	398	Shared Neighborhood Hits	164
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PLCG1_HUMAN
NC score	0.390645 (rank : 92)	θ value	5.44631e-05 (rank : 66)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV3_MOUSE
NC score	0.387884 (rank : 93)	θ value	0.00228821 (rank : 108)
Query Neighborhood Hits	358	Target Neighborhood Hits	404	Shared Neighborhood Hits	165
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG2_HUMAN
NC score	0.384233 (rank : 94)	θ value	0.00298849 (rank : 109)
Query Neighborhood Hits	358	Target Neighborhood Hits	280	Shared Neighborhood Hits	147
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ARHG4_HUMAN
NC score	0.381574 (rank : 95)	θ value	0.00390308 (rank : 110)
Query Neighborhood Hits	358	Target Neighborhood Hits	242	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NPHP1_HUMAN
NC score	0.372413 (rank : 96)	θ value	1.06291 (rank : 206)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	140
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SNX18_MOUSE
NC score	0.370061 (rank : 97)	θ value	0.00869519 (rank : 116)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	119
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG9_MOUSE
NC score	0.367492 (rank : 98)	θ value	0.00175202 (rank : 100)
Query Neighborhood Hits	358	Target Neighborhood Hits	234	Shared Neighborhood Hits	148
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SNX18_HUMAN
NC score	0.366273 (rank : 99)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	358	Target Neighborhood Hits	207	Shared Neighborhood Hits	122
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG9_HUMAN
NC score	0.364947 (rank : 100)	θ value	0.00175202 (rank : 99)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	147
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

RHG04_HUMAN
NC score	0.356836 (rank : 101)	θ value	0.000121331 (rank : 75)
Query Neighborhood Hits	358	Target Neighborhood Hits	307	Shared Neighborhood Hits	157
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NOXO1_MOUSE
NC score	0.352205 (rank : 102)	θ value	0.00665767 (rank : 112)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PEX13_HUMAN
NC score	0.348789 (rank : 103)	θ value	2.36792 (rank : 248)
Query Neighborhood Hits	358	Target Neighborhood Hits	128	Shared Neighborhood Hits	105
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.347766 (rank : 104)	θ value	3.0926 (rank : 259)
Query Neighborhood Hits	358	Target Neighborhood Hits	126	Shared Neighborhood Hits	107
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_HUMAN
NC score	0.340642 (rank : 105)	θ value	0.163984 (rank : 154)
Query Neighborhood Hits	358	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
NC score	0.333527 (rank : 106)	θ value	0.0252991 (rank : 130)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SRGP2_MOUSE
NC score	0.320126 (rank : 107)	θ value	5.44631e-05 (rank : 67)
Query Neighborhood Hits	358	Target Neighborhood Hits	324	Shared Neighborhood Hits	150
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.315601 (rank : 108)	θ value	4.1701e-05 (rank : 63)
Query Neighborhood Hits	358	Target Neighborhood Hits	331	Shared Neighborhood Hits	149
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

IASPP_HUMAN
NC score	0.312546 (rank : 109)	θ value	0.0193708 (rank : 124)
Query Neighborhood Hits	358	Target Neighborhood Hits	688	Shared Neighborhood Hits	180
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASPP1_MOUSE
NC score	0.306637 (rank : 110)	θ value	0.00228821 (rank : 104)
Query Neighborhood Hits	358	Target Neighborhood Hits	1244	Shared Neighborhood Hits	238
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SRGP1_HUMAN
NC score	0.300606 (rank : 111)	θ value	0.00134147 (rank : 97)
Query Neighborhood Hits	358	Target Neighborhood Hits	390	Shared Neighborhood Hits	146
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.298407 (rank : 112)	θ value	0.00228821 (rank : 105)
Query Neighborhood Hits	358	Target Neighborhood Hits	432	Shared Neighborhood Hits	157
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ASPP1_HUMAN
NC score	0.296310 (rank : 113)	θ value	0.00175202 (rank : 101)
Query Neighborhood Hits	358	Target Neighborhood Hits	956	Shared Neighborhood Hits	190
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_MOUSE
NC score	0.296209 (rank : 114)	θ value	0.0193708 (rank : 125)
Query Neighborhood Hits	358	Target Neighborhood Hits	1024	Shared Neighborhood Hits	221
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SHLB1_MOUSE
NC score	0.293832 (rank : 115)	θ value	0.0961366 (rank : 144)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ARHG4_MOUSE
NC score	0.293753 (rank : 116)	θ value	0.21417 (rank : 158)
Query Neighborhood Hits	358	Target Neighborhood Hits	185	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RHG26_HUMAN
NC score	0.289375 (rank : 117)	θ value	0.0148317 (rank : 121)
Query Neighborhood Hits	358	Target Neighborhood Hits	281	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SHLB1_HUMAN
NC score	0.288556 (rank : 118)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	358	Target Neighborhood Hits	96	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

MYO1F_HUMAN
NC score	0.284631 (rank : 119)	θ value	1.06045e-08 (rank : 10)
Query Neighborhood Hits	358	Target Neighborhood Hits	275	Shared Neighborhood Hits	173
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.283197 (rank : 120)	θ value	1.38499e-08 (rank : 11)
Query Neighborhood Hits	358	Target Neighborhood Hits	262	Shared Neighborhood Hits	168
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1E_HUMAN
NC score	0.274976 (rank : 121)	θ value	1.53129e-07 (rank : 20)
Query Neighborhood Hits	358	Target Neighborhood Hits	293	Shared Neighborhood Hits	168
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ANM2_HUMAN
NC score	0.274788 (rank : 122)	θ value	0.813845 (rank : 192)
Query Neighborhood Hits	358	Target Neighborhood Hits	175	Shared Neighborhood Hits	142
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

NOXO1_HUMAN
NC score	0.266552 (rank : 123)	θ value	0.163984 (rank : 152)
Query Neighborhood Hits	358	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

DDEF1_MOUSE
NC score	0.266109 (rank : 124)	θ value	0.0330416 (rank : 132)
Query Neighborhood Hits	358	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RIMB2_HUMAN
NC score	0.265394 (rank : 125)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	114
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TCGAP_MOUSE
NC score	0.262393 (rank : 126)	θ value	0.00175202 (rank : 103)
Query Neighborhood Hits	358	Target Neighborhood Hits	409	Shared Neighborhood Hits	136
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RIMB2_MOUSE
NC score	0.257707 (rank : 127)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	358	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TCGAP_HUMAN
NC score	0.257307 (rank : 128)	θ value	0.00134147 (rank : 98)
Query Neighborhood Hits	358	Target Neighborhood Hits	872	Shared Neighborhood Hits	201
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANM2_MOUSE
NC score	0.255121 (rank : 129)	θ value	1.81305 (rank : 230)
Query Neighborhood Hits	358	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SPTA2_HUMAN
NC score	0.248131 (rank : 130)	θ value	0.00102713 (rank : 94)
Query Neighborhood Hits	358	Target Neighborhood Hits	888	Shared Neighborhood Hits	166
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SHLB2_MOUSE
NC score	0.243873 (rank : 131)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	358	Target Neighborhood Hits	88	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.242121 (rank : 132)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	358	Target Neighborhood Hits	86	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SPTA1_MOUSE
NC score	0.240497 (rank : 133)	θ value	0.00020696 (rank : 77)
Query Neighborhood Hits	358	Target Neighborhood Hits	675	Shared Neighborhood Hits	154
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DDEF2_MOUSE
NC score	0.237317 (rank : 134)	θ value	0.21417 (rank : 163)
Query Neighborhood Hits	358	Target Neighborhood Hits	625	Shared Neighborhood Hits	157
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPTA1_HUMAN
NC score	0.235316 (rank : 135)	θ value	0.000461057 (rank : 87)
Query Neighborhood Hits	358	Target Neighborhood Hits	748	Shared Neighborhood Hits	163
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DDEF2_HUMAN
NC score	0.234213 (rank : 136)	θ value	0.21417 (rank : 162)
Query Neighborhood Hits	358	Target Neighborhood Hits	599	Shared Neighborhood Hits	161
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DOCK1_HUMAN
NC score	0.224287 (rank : 137)	θ value	0.000461057 (rank : 86)
Query Neighborhood Hits	358	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ASPP2_HUMAN
NC score	0.222304 (rank : 138)	θ value	0.279714 (rank : 169)
Query Neighborhood Hits	358	Target Neighborhood Hits	1156	Shared Neighborhood Hits	180
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ES8L3_MOUSE
NC score	0.215561 (rank : 139)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	358	Target Neighborhood Hits	168	Shared Neighborhood Hits	131
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SHAN2_MOUSE
NC score	0.214474 (rank : 140)	θ value	0.21417 (rank : 167)
Query Neighborhood Hits	358	Target Neighborhood Hits	446	Shared Neighborhood Hits	120
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SNX9_HUMAN
NC score	0.202119 (rank : 141)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	358	Target Neighborhood Hits	148	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

AMPH_HUMAN
NC score	0.200888 (rank : 142)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	358	Target Neighborhood Hits	455	Shared Neighborhood Hits	122
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
NC score	0.198198 (rank : 143)	θ value	0.0431538 (rank : 134)
Query Neighborhood Hits	358	Target Neighborhood Hits	291	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ES8L3_HUMAN
NC score	0.195835 (rank : 144)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SPN90_HUMAN
NC score	0.183864 (rank : 145)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

M3KL4_HUMAN
NC score	0.183734 (rank : 146)	θ value	2.44474e-05 (rank : 55)
Query Neighborhood Hits	358	Target Neighborhood Hits	1087	Shared Neighborhood Hits	178
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SNX9_MOUSE
NC score	0.179246 (rank : 147)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	358	Target Neighborhood Hits	141	Shared Neighborhood Hits	82
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SHAN1_HUMAN
NC score	0.176344 (rank : 148)	θ value	0.279714 (rank : 171)
Query Neighborhood Hits	358	Target Neighborhood Hits	1041	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ES8L2_HUMAN
NC score	0.175977 (rank : 149)	θ value	8.99809 (rank : 338)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	118
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHG5_HUMAN
NC score	0.175443 (rank : 150)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	358	Target Neighborhood Hits	172	Shared Neighborhood Hits	80
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

STS2_HUMAN
NC score	0.174821 (rank : 151)	θ value	8.99809 (rank : 352)
Query Neighborhood Hits	358	Target Neighborhood Hits	108	Shared Neighborhood Hits	76
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

FGR_HUMAN
NC score	0.169544 (rank : 152)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	358	Target Neighborhood Hits	1067	Shared Neighborhood Hits	172
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_MOUSE
NC score	0.169412 (rank : 153)	θ value	0.0113563 (rank : 120)
Query Neighborhood Hits	358	Target Neighborhood Hits	1073	Shared Neighborhood Hits	177
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

M3K11_HUMAN
NC score	0.168929 (rank : 154)	θ value	0.000270298 (rank : 80)
Query Neighborhood Hits	358	Target Neighborhood Hits	1136	Shared Neighborhood Hits	190
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

EPS8_MOUSE
NC score	0.167206 (rank : 155)	θ value	6.88961 (rank : 307)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	114
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

P85A_MOUSE
NC score	0.166493 (rank : 156)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	358	Target Neighborhood Hits	435	Shared Neighborhood Hits	108
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

FYN_HUMAN
NC score	0.166144 (rank : 157)	θ value	0.0113563 (rank : 119)
Query Neighborhood Hits	358	Target Neighborhood Hits	1078	Shared Neighborhood Hits	176
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.165244 (rank : 158)	θ value	0.0148317 (rank : 122)
Query Neighborhood Hits	358	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP2_MOUSE
NC score	0.164467 (rank : 159)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	358	Target Neighborhood Hits	136	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ES8L2_MOUSE
NC score	0.164087 (rank : 160)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	358	Target Neighborhood Hits	169	Shared Neighborhood Hits	111
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SLAP2_HUMAN
NC score	0.163517 (rank : 161)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	358	Target Neighborhood Hits	139	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

YES_HUMAN
NC score	0.163492 (rank : 162)	θ value	0.0193708 (rank : 126)
Query Neighborhood Hits	358	Target Neighborhood Hits	1059	Shared Neighborhood Hits	173
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
NC score	0.163456 (rank : 163)	θ value	0.00134147 (rank : 96)
Query Neighborhood Hits	358	Target Neighborhood Hits	1069	Shared Neighborhood Hits	173
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.162257 (rank : 164)	θ value	0.0252991 (rank : 131)
Query Neighborhood Hits	358	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

M3K9_HUMAN
NC score	0.162105 (rank : 165)	θ value	0.000158464 (rank : 76)
Query Neighborhood Hits	358	Target Neighborhood Hits	1123	Shared Neighborhood Hits	189
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SPN90_MOUSE
NC score	0.160752 (rank : 166)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

NGEF_MOUSE
NC score	0.160500 (rank : 167)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.159150 (rank : 168)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RIMB1_HUMAN
NC score	0.157432 (rank : 169)	θ value	6.88961 (rank : 316)
Query Neighborhood Hits	358	Target Neighborhood Hits	1479	Shared Neighborhood Hits	183
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

P85A_HUMAN
NC score	0.157296 (rank : 170)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	358	Target Neighborhood Hits	479	Shared Neighborhood Hits	104
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CIP4_HUMAN
NC score	0.155743 (rank : 171)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	358	Target Neighborhood Hits	374	Shared Neighborhood Hits	74
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

EPS8_HUMAN
NC score	0.155524 (rank : 172)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	100
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

BIN1_HUMAN
NC score	0.151123 (rank : 173)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	358	Target Neighborhood Hits	335	Shared Neighborhood Hits	96
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

ES8L1_HUMAN
NC score	0.151024 (rank : 174)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	358	Target Neighborhood Hits	162	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RIMB1_MOUSE
NC score	0.150603 (rank : 175)	θ value	4.03905 (rank : 274)
Query Neighborhood Hits	358	Target Neighborhood Hits	1376	Shared Neighborhood Hits	180
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SLAP1_HUMAN
NC score	0.150351 (rank : 176)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	358	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BIN1_MOUSE
NC score	0.149073 (rank : 177)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	358	Target Neighborhood Hits	283	Shared Neighborhood Hits	93
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

SLAP1_MOUSE
NC score	0.148218 (rank : 178)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	358	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

M3K10_HUMAN
NC score	0.148166 (rank : 179)	θ value	0.00228821 (rank : 106)
Query Neighborhood Hits	358	Target Neighborhood Hits	1071	Shared Neighborhood Hits	164
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

HCK_MOUSE
NC score	0.145117 (rank : 180)	θ value	0.0330416 (rank : 133)
Query Neighborhood Hits	358	Target Neighborhood Hits	1029	Shared Neighborhood Hits	171
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.143022 (rank : 181)	θ value	0.125558 (rank : 146)
Query Neighborhood Hits	358	Target Neighborhood Hits	1035	Shared Neighborhood Hits	172
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BTK_HUMAN
NC score	0.142659 (rank : 182)	θ value	0.163984 (rank : 150)
Query Neighborhood Hits	358	Target Neighborhood Hits	1026	Shared Neighborhood Hits	171
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ES8L1_MOUSE
NC score	0.142131 (rank : 183)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	358	Target Neighborhood Hits	143	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

STS1_MOUSE
NC score	0.140495 (rank : 184)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	358	Target Neighborhood Hits	104	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SRC_MOUSE
NC score	0.140001 (rank : 185)	θ value	0.0563607 (rank : 139)
Query Neighborhood Hits	358	Target Neighborhood Hits	1033	Shared Neighborhood Hits	158
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FRK_HUMAN
NC score	0.136547 (rank : 186)	θ value	0.0193708 (rank : 123)
Query Neighborhood Hits	358	Target Neighborhood Hits	1058	Shared Neighborhood Hits	174
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

STS1_HUMAN
NC score	0.136403 (rank : 187)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	358	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

P85B_HUMAN
NC score	0.135576 (rank : 188)	θ value	5.27518 (rank : 287)
Query Neighborhood Hits	358	Target Neighborhood Hits	543	Shared Neighborhood Hits	84
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHGG_MOUSE
NC score	0.135498 (rank : 189)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	358	Target Neighborhood Hits	152	Shared Neighborhood Hits	56
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BTK_MOUSE
NC score	0.134870 (rank : 190)	θ value	0.62314 (rank : 186)
Query Neighborhood Hits	358	Target Neighborhood Hits	1017	Shared Neighborhood Hits	161
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PKHG1_HUMAN
NC score	0.133236 (rank : 191)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RUSC2_HUMAN
NC score	0.133116 (rank : 192)	θ value	6.88961 (rank : 318)
Query Neighborhood Hits	358	Target Neighborhood Hits	205	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RASA1_HUMAN
NC score	0.132523 (rank : 193)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	358	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LYN_HUMAN
NC score	0.127869 (rank : 194)	θ value	1.38821 (rank : 221)
Query Neighborhood Hits	358	Target Neighborhood Hits	1022	Shared Neighborhood Hits	156
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

RUSC2_MOUSE
NC score	0.127549 (rank : 195)	θ value	0.163984 (rank : 155)
Query Neighborhood Hits	358	Target Neighborhood Hits	305	Shared Neighborhood Hits	92
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

LYN_MOUSE
NC score	0.127348 (rank : 196)	θ value	1.06291 (rank : 204)
Query Neighborhood Hits	358	Target Neighborhood Hits	1023	Shared Neighborhood Hits	157
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PREX1_HUMAN
NC score	0.126158 (rank : 197)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

MCF2L_MOUSE
NC score	0.124092 (rank : 198)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	358	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

SLY_MOUSE
NC score	0.122469 (rank : 199)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	358	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

TIAM1_MOUSE
NC score	0.122006 (rank : 200)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	358	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_HUMAN
NC score	0.121126 (rank : 201)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	358	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

CSK_MOUSE
NC score	0.121049 (rank : 202)	θ value	0.0563607 (rank : 137)
Query Neighborhood Hits	358	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.120944 (rank : 203)	θ value	0.0563607 (rank : 136)
Query Neighborhood Hits	358	Target Neighborhood Hits	1009	Shared Neighborhood Hits	134
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TIAM1_HUMAN
NC score	0.120942 (rank : 204)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	30
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_MOUSE
NC score	0.120882 (rank : 205)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	358	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

LCP2_HUMAN
NC score	0.119163 (rank : 206)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	358	Target Neighborhood Hits	531	Shared Neighborhood Hits	122
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

P85B_MOUSE
NC score	0.119162 (rank : 207)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	358	Target Neighborhood Hits	519	Shared Neighborhood Hits	76
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ARHGG_HUMAN
NC score	0.119086 (rank : 208)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	358	Target Neighborhood Hits	129	Shared Neighborhood Hits	46
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DAPP1_MOUSE
NC score	0.118890 (rank : 209)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_HUMAN
NC score	0.118345 (rank : 210)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG8_MOUSE
NC score	0.117097 (rank : 211)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	358	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TEC_HUMAN
NC score	0.116576 (rank : 212)	θ value	0.0961366 (rank : 145)
Query Neighborhood Hits	358	Target Neighborhood Hits	1006	Shared Neighborhood Hits	138
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
NC score	0.115911 (rank : 213)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	358	Target Neighborhood Hits	994	Shared Neighborhood Hits	138
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TXK_MOUSE
NC score	0.115834 (rank : 214)	θ value	0.813845 (rank : 203)
Query Neighborhood Hits	358	Target Neighborhood Hits	980	Shared Neighborhood Hits	134
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TEC_MOUSE
NC score	0.111848 (rank : 215)	θ value	0.163984 (rank : 157)
Query Neighborhood Hits	358	Target Neighborhood Hits	1006	Shared Neighborhood Hits	138
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_MOUSE
NC score	0.111367 (rank : 216)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	358	Target Neighborhood Hits	992	Shared Neighborhood Hits	128
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ARHG8_HUMAN
NC score	0.110672 (rank : 217)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	358	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BI2L1_HUMAN
NC score	0.110036 (rank : 218)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PTK6_MOUSE
NC score	0.108588 (rank : 219)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	358	Target Neighborhood Hits	1026	Shared Neighborhood Hits	151
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RGS3_MOUSE
NC score	0.107823 (rank : 220)	θ value	1.43324e-05 (rank : 51)
Query Neighborhood Hits	358	Target Neighborhood Hits	1621	Shared Neighborhood Hits	171
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

LCK_HUMAN
NC score	0.107675 (rank : 221)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	358	Target Neighborhood Hits	987	Shared Neighborhood Hits	115
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PTK6_HUMAN
NC score	0.106835 (rank : 222)	θ value	8.99809 (rank : 347)
Query Neighborhood Hits	358	Target Neighborhood Hits	1020	Shared Neighborhood Hits	154
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

SLY_HUMAN
NC score	0.106749 (rank : 223)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	358	Target Neighborhood Hits	81	Shared Neighborhood Hits	53
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

LCK_MOUSE
NC score	0.106658 (rank : 224)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	358	Target Neighborhood Hits	981	Shared Neighborhood Hits	113
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

ARHGA_MOUSE
NC score	0.104866 (rank : 225)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ABL1_MOUSE
NC score	0.104566 (rank : 226)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	358	Target Neighborhood Hits	1178	Shared Neighborhood Hits	156
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ITK_HUMAN
NC score	0.104414 (rank : 227)	θ value	0.813845 (rank : 197)
Query Neighborhood Hits	358	Target Neighborhood Hits	1016	Shared Neighborhood Hits	133
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SH21B_MOUSE
NC score	0.103719 (rank : 228)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_HUMAN
NC score	0.103599 (rank : 229)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	358	Target Neighborhood Hits	971	Shared Neighborhood Hits	122
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABL1_HUMAN
NC score	0.103024 (rank : 230)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	358	Target Neighborhood Hits	1220	Shared Neighborhood Hits	153
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

GRB14_MOUSE
NC score	0.102863 (rank : 231)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	358	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SH21B_HUMAN
NC score	0.102277 (rank : 232)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	358	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

P55G_HUMAN
NC score	0.101935 (rank : 233)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	358	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRB14_HUMAN
NC score	0.101887 (rank : 234)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MCF2_HUMAN
NC score	0.101792 (rank : 235)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	25
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

DOCK2_HUMAN
NC score	0.100536 (rank : 236)	θ value	0.163984 (rank : 151)
Query Neighborhood Hits	358	Target Neighborhood Hits	90	Shared Neighborhood Hits	45
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

P55G_MOUSE
NC score	0.099945 (rank : 237)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	358	Target Neighborhood Hits	401	Shared Neighborhood Hits	52
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHE_MOUSE
NC score	0.099941 (rank : 238)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	358	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PPIP2_HUMAN
NC score	0.099576 (rank : 239)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	358	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

CHIN_MOUSE
NC score	0.099461 (rank : 240)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	358	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ITK_MOUSE
NC score	0.099154 (rank : 241)	θ value	0.47712 (rank : 184)
Query Neighborhood Hits	358	Target Neighborhood Hits	985	Shared Neighborhood Hits	121
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SHE_HUMAN
NC score	0.098557 (rank : 242)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	358	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

CHIN_HUMAN
NC score	0.098443 (rank : 243)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ABL2_HUMAN
NC score	0.098355 (rank : 244)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	358	Target Neighborhood Hits	1045	Shared Neighborhood Hits	129
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARHGA_HUMAN
NC score	0.097947 (rank : 245)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	21
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BLNK_MOUSE
NC score	0.097608 (rank : 246)	θ value	8.99809 (rank : 329)
Query Neighborhood Hits	358	Target Neighborhood Hits	296	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BCR_HUMAN
NC score	0.097508 (rank : 247)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

MDC1_HUMAN
NC score	0.097011 (rank : 248)	θ value	1.06291 (rank : 205)
Query Neighborhood Hits	358	Target Neighborhood Hits	1446	Shared Neighborhood Hits	134
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CHIO_HUMAN
NC score	0.096968 (rank : 249)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	358	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SHC3_MOUSE
NC score	0.096590 (rank : 250)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	48
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHB_MOUSE
NC score	0.096560 (rank : 251)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

APS_HUMAN
NC score	0.096257 (rank : 252)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	358	Target Neighborhood Hits	162	Shared Neighborhood Hits	43
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ECT2_MOUSE
NC score	0.096211 (rank : 253)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	358	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BAIP2_MOUSE
NC score	0.096114 (rank : 254)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	358	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

SHB_HUMAN
NC score	0.094211 (rank : 255)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	358	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

BAIP2_HUMAN
NC score	0.093791 (rank : 256)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	358	Target Neighborhood Hits	192	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SHC1_MOUSE
NC score	0.093756 (rank : 257)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	358	Target Neighborhood Hits	180	Shared Neighborhood Hits	55
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

NACAM_MOUSE
NC score	0.093216 (rank : 258)	θ value	6.88961 (rank : 312)
Query Neighborhood Hits	358	Target Neighborhood Hits	1866	Shared Neighborhood Hits	189
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ECT2_HUMAN
NC score	0.092936 (rank : 259)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	358	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SHC1_HUMAN
NC score	0.092838 (rank : 260)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRB7_MOUSE
NC score	0.092801 (rank : 261)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	358	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

DOCK2_MOUSE
NC score	0.091255 (rank : 262)	θ value	1.81305 (rank : 234)
Query Neighborhood Hits	358	Target Neighborhood Hits	104	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

SON_HUMAN
NC score	0.091102 (rank : 263)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	358	Target Neighborhood Hits	1568	Shared Neighborhood Hits	169
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

BI2L1_MOUSE
NC score	0.091014 (rank : 264)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	358	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHC2_HUMAN
NC score	0.090407 (rank : 265)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	51
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

ARHG1_HUMAN
NC score	0.090065 (rank : 266)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	358	Target Neighborhood Hits	176	Shared Neighborhood Hits	28
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGC_HUMAN
NC score	0.090046 (rank : 267)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	358	Target Neighborhood Hits	351	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SHC3_HUMAN
NC score	0.089692 (rank : 268)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	358	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC2_MOUSE
NC score	0.089606 (rank : 269)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	46
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

ARHGC_MOUSE
NC score	0.089513 (rank : 270)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	358	Target Neighborhood Hits	344	Shared Neighborhood Hits	30
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SHD_HUMAN
NC score	0.089237 (rank : 271)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	50
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

HSH2D_HUMAN
NC score	0.088887 (rank : 272)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	358	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LCP2_MOUSE
NC score	0.088856 (rank : 273)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	358	Target Neighborhood Hits	177	Shared Neighborhood Hits	58
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SASH1_HUMAN
NC score	0.088449 (rank : 274)	θ value	3.0926 (rank : 262)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	81
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

ARHGB_HUMAN
NC score	0.088042 (rank : 275)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	358	Target Neighborhood Hits	375	Shared Neighborhood Hits	29
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

PPIP2_MOUSE
NC score	0.087743 (rank : 276)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	358	Target Neighborhood Hits	308	Shared Neighborhood Hits	25
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SHD_MOUSE
NC score	0.087649 (rank : 277)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	358	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ABR_HUMAN
NC score	0.087376 (rank : 278)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	358	Target Neighborhood Hits	166	Shared Neighborhood Hits	31
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

3BP1_HUMAN
NC score	0.087278 (rank : 279)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	358	Target Neighborhood Hits	376	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SRMS_MOUSE
NC score	0.087016 (rank : 280)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	358	Target Neighborhood Hits	964	Shared Neighborhood Hits	107
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

DREB_MOUSE
NC score	0.086361 (rank : 281)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	358	Target Neighborhood Hits	446	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

LNK_HUMAN
NC score	0.086119 (rank : 282)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
NC score	0.085476 (rank : 283)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	358	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

JIP2_HUMAN
NC score	0.085326 (rank : 284)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	358	Target Neighborhood Hits	288	Shared Neighborhood Hits	73
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

EM55_HUMAN
NC score	0.084422 (rank : 285)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	84
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SH22A_MOUSE
NC score	0.083828 (rank : 286)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	358	Target Neighborhood Hits	179	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

GRB10_MOUSE
NC score	0.082819 (rank : 287)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	45
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

DREB_HUMAN
NC score	0.082797 (rank : 288)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	358	Target Neighborhood Hits	450	Shared Neighborhood Hits	38
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

HAPIP_HUMAN
NC score	0.082794 (rank : 289)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	27
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

GNRP_MOUSE
NC score	0.082640 (rank : 290)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	358	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SASH1_MOUSE
NC score	0.082634 (rank : 291)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	78
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

BAT2_HUMAN
NC score	0.082549 (rank : 292)	θ value	0.813845 (rank : 194)
Query Neighborhood Hits	358	Target Neighborhood Hits	931	Shared Neighborhood Hits	113
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SH21A_HUMAN
NC score	0.082192 (rank : 293)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	358	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

GRB7_HUMAN
NC score	0.082169 (rank : 294)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	358	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

EM55_MOUSE
NC score	0.081472 (rank : 295)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	358	Target Neighborhood Hits	221	Shared Neighborhood Hits	79
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SH21A_MOUSE
NC score	0.081337 (rank : 296)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	358	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

GRB10_HUMAN
NC score	0.081162 (rank : 297)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	358	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

FUT8_HUMAN
NC score	0.081073 (rank : 298)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	358	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

MDC1_MOUSE
NC score	0.080747 (rank : 299)	θ value	1.38821 (rank : 222)
Query Neighborhood Hits	358	Target Neighborhood Hits	998	Shared Neighborhood Hits	127
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

FGD3_MOUSE
NC score	0.080445 (rank : 300)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	358	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RGNEF_MOUSE
NC score	0.080052 (rank : 301)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	358	Target Neighborhood Hits	641	Shared Neighborhood Hits	43
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG1_MOUSE
NC score	0.079423 (rank : 302)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	358	Target Neighborhood Hits	266	Shared Neighborhood Hits	44
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RGS3_HUMAN
NC score	0.079100 (rank : 303)	θ value	0.365318 (rank : 178)
Query Neighborhood Hits	358	Target Neighborhood Hits	1375	Shared Neighborhood Hits	151
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

BLNK_HUMAN
NC score	0.078916 (rank : 304)	θ value	6.88961 (rank : 305)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

JIP2_MOUSE
NC score	0.078911 (rank : 305)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

TARSH_HUMAN
NC score	0.078646 (rank : 306)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	358	Target Neighborhood Hits	768	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

RHG09_HUMAN
NC score	0.078578 (rank : 307)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	358	Target Neighborhood Hits	186	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

FGD4_MOUSE
NC score	0.078384 (rank : 308)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

JIP1_HUMAN
NC score	0.078276 (rank : 309)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	358	Target Neighborhood Hits	271	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SON_MOUSE
NC score	0.078081 (rank : 310)	θ value	0.00228821 (rank : 107)
Query Neighborhood Hits	358	Target Neighborhood Hits	957	Shared Neighborhood Hits	113
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SRMS_HUMAN
NC score	0.077947 (rank : 311)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	358	Target Neighborhood Hits	946	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FGD4_HUMAN
NC score	0.077883 (rank : 312)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	358	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

RHG12_MOUSE
NC score	0.077719 (rank : 313)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	358	Target Neighborhood Hits	204	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PTN11_MOUSE
NC score	0.077608 (rank : 314)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.077599 (rank : 315)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	358	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

LBC_HUMAN
NC score	0.077251 (rank : 316)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	358	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

OGFR_HUMAN
NC score	0.077205 (rank : 317)	θ value	8.99809 (rank : 344)
Query Neighborhood Hits	358	Target Neighborhood Hits	1582	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

JIP1_MOUSE
NC score	0.076691 (rank : 318)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	358	Target Neighborhood Hits	259	Shared Neighborhood Hits	77
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ARHGF_HUMAN
NC score	0.076433 (rank : 319)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	358	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PRRT3_HUMAN
NC score	0.076271 (rank : 320)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	358	Target Neighborhood Hits	998	Shared Neighborhood Hits	139
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CN155_HUMAN
NC score	0.075862 (rank : 321)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	358	Target Neighborhood Hits	385	Shared Neighborhood Hits	59
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

MATK_MOUSE
NC score	0.075496 (rank : 322)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	358	Target Neighborhood Hits	952	Shared Neighborhood Hits	87
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

BAT2_MOUSE
NC score	0.074866 (rank : 323)	θ value	1.81305 (rank : 231)
Query Neighborhood Hits	358	Target Neighborhood Hits	947	Shared Neighborhood Hits	116
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

RHG12_HUMAN
NC score	0.074861 (rank : 324)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	358	Target Neighborhood Hits	190	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

MATK_HUMAN
NC score	0.074652 (rank : 325)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	358	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SH24A_HUMAN
NC score	0.074574 (rank : 326)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	358	Target Neighborhood Hits	455	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

FGD3_HUMAN
NC score	0.074323 (rank : 327)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	358	Target Neighborhood Hits	249	Shared Neighborhood Hits	28
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD2_HUMAN
NC score	0.073633 (rank : 328)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	358	Target Neighborhood Hits	151	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

APS_MOUSE
NC score	0.073174 (rank : 329)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	358	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FGD1_HUMAN
NC score	0.073066 (rank : 330)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	358	Target Neighborhood Hits	367	Shared Neighborhood Hits	54
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG2_HUMAN
NC score	0.072968 (rank : 331)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	358	Target Neighborhood Hits	142	Shared Neighborhood Hits	23
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

GNRP_HUMAN
NC score	0.072935 (rank : 332)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	358	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

WASIP_HUMAN
NC score	0.072163 (rank : 333)	θ value	1.81305 (rank : 241)
Query Neighborhood Hits	358	Target Neighborhood Hits	458	Shared Neighborhood Hits	63
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

NCOA6_HUMAN
NC score	0.072043 (rank : 334)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	358	Target Neighborhood Hits	1202	Shared Neighborhood Hits	142
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

3BP1_MOUSE
NC score	0.071675 (rank : 335)	θ value	2.36792 (rank : 242)
Query Neighborhood Hits	358	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ARHG2_MOUSE
NC score	0.071638 (rank : 336)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	358	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

SAMN1_HUMAN
NC score	0.071426 (rank : 337)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	358	Target Neighborhood Hits	74	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SH2D3_HUMAN
NC score	0.071244 (rank : 338)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	358	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH22A_HUMAN
NC score	0.070874 (rank : 339)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	358	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

FGD2_MOUSE
NC score	0.070352 (rank : 340)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	358	Target Neighborhood Hits	163	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_MOUSE
NC score	0.070072 (rank : 341)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	358	Target Neighborhood Hits	387	Shared Neighborhood Hits	54
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MPP6_HUMAN
NC score	0.069998 (rank : 342)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	358	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SH2D3_MOUSE
NC score	0.069939 (rank : 343)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

YLPM1_MOUSE
NC score	0.069915 (rank : 344)	θ value	0.279714 (rank : 173)
Query Neighborhood Hits	358	Target Neighborhood Hits	505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

YLPM1_HUMAN
NC score	0.069355 (rank : 345)	θ value	0.62314 (rank : 190)
Query Neighborhood Hits	358	Target Neighborhood Hits	670	Shared Neighborhood Hits	73
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

CS016_HUMAN
NC score	0.068893 (rank : 346)	θ value	0.21417 (rank : 161)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	54
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DOCK4_MOUSE
NC score	0.068740 (rank : 347)	θ value	0.47712 (rank : 182)
Query Neighborhood Hits	358	Target Neighborhood Hits	210	Shared Neighborhood Hits	50
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

MUC1_HUMAN
NC score	0.068312 (rank : 348)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	358	Target Neighborhood Hits	975	Shared Neighborhood Hits	124
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

CHIO_MOUSE
NC score	0.068297 (rank : 349)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	358	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

PTN6_MOUSE
NC score	0.067711 (rank : 350)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

WIRE_MOUSE
NC score	0.067143 (rank : 351)	θ value	0.47712 (rank : 185)
Query Neighborhood Hits	358	Target Neighborhood Hits	310	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

SAMN1_MOUSE
NC score	0.066967 (rank : 352)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	358	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

MPP6_MOUSE
NC score	0.066793 (rank : 353)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

WIRE_HUMAN
NC score	0.066790 (rank : 354)	θ value	0.62314 (rank : 189)
Query Neighborhood Hits	358	Target Neighborhood Hits	329	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

FER_HUMAN
NC score	0.066583 (rank : 355)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	358	Target Neighborhood Hits	1278	Shared Neighborhood Hits	86
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

PTN6_HUMAN
NC score	0.066483 (rank : 356)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	358	Target Neighborhood Hits	234	Shared Neighborhood Hits	49
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

RAPH1_HUMAN
NC score	0.066371 (rank : 357)	θ value	1.06291 (rank : 208)
Query Neighborhood Hits	358	Target Neighborhood Hits	593	Shared Neighborhood Hits	87
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RERE_HUMAN
NC score	0.066154 (rank : 358)	θ value	0.21417 (rank : 166)
Query Neighborhood Hits	358	Target Neighborhood Hits	779	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

PCLO_HUMAN
NC score	0.065886 (rank : 359)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	358	Target Neighborhood Hits	2046	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

IWS1_MOUSE
NC score	0.065801 (rank : 360)	θ value	0.0252991 (rank : 129)
Query Neighborhood Hits	358	Target Neighborhood Hits	1258	Shared Neighborhood Hits	99
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

FUT8_MOUSE
NC score	0.065570 (rank : 361)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	358	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SOS1_HUMAN
NC score	0.065031 (rank : 362)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	358	Target Neighborhood Hits	274	Shared Neighborhood Hits	39
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

DOCK4_HUMAN
NC score	0.064789 (rank : 363)	θ value	1.38821 (rank : 216)
Query Neighborhood Hits	358	Target Neighborhood Hits	237	Shared Neighborhood Hits	59
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

MNT_MOUSE
NC score	0.064680 (rank : 364)	θ value	0.279714 (rank : 170)
Query Neighborhood Hits	358	Target Neighborhood Hits	432	Shared Neighborhood Hits	61
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MLL4_HUMAN
NC score	0.064673 (rank : 365)	θ value	0.125558 (rank : 147)
Query Neighborhood Hits	358	Target Neighborhood Hits	722	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

BCAR3_MOUSE
NC score	0.064530 (rank : 366)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	358	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

SOS1_MOUSE
NC score	0.064508 (rank : 367)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	358	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

BCAR3_HUMAN
NC score	0.064298 (rank : 368)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	358	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

RERE_MOUSE
NC score	0.064281 (rank : 369)	θ value	0.163984 (rank : 153)
Query Neighborhood Hits	358	Target Neighborhood Hits	785	Shared Neighborhood Hits	74
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

MLL3_HUMAN
NC score	0.064220 (rank : 370)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	358	Target Neighborhood Hits	1644	Shared Neighborhood Hits	153
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

FARP2_MOUSE
NC score	0.064076 (rank : 371)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	358	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ACK1_HUMAN
NC score	0.063825 (rank : 372)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	358	Target Neighborhood Hits	1140	Shared Neighborhood Hits	138
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
NC score	0.063390 (rank : 373)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	358	Target Neighborhood Hits	1080	Shared Neighborhood Hits	128
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

PELP1_MOUSE
NC score	0.063323 (rank : 374)	θ value	0.813845 (rank : 200)
Query Neighborhood Hits	358	Target Neighborhood Hits	709	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

RHG25_MOUSE
NC score	0.063148 (rank : 375)	θ value	1.06291 (rank : 209)
Query Neighborhood Hits	358	Target Neighborhood Hits	492	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

WASIP_MOUSE
NC score	0.063047 (rank : 376)	θ value	6.88961 (rank : 324)
Query Neighborhood Hits	358	Target Neighborhood Hits	392	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

BMX_MOUSE
NC score	0.062931 (rank : 377)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	358	Target Neighborhood Hits	912	Shared Neighborhood Hits	61
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

SOCS7_MOUSE
NC score	0.062744 (rank : 378)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	358	Target Neighborhood Hits	154	Shared Neighborhood Hits	42
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

BMX_HUMAN
NC score	0.062602 (rank : 379)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	358	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FGD6_MOUSE
NC score	0.062089 (rank : 380)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	358	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

MISS_MOUSE
NC score	0.061836 (rank : 381)	θ value	1.38821 (rank : 223)
Query Neighborhood Hits	358	Target Neighborhood Hits	444	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

CJ078_MOUSE
NC score	0.061781 (rank : 382)	θ value	0.365318 (rank : 174)
Query Neighborhood Hits	358	Target Neighborhood Hits	559	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

KSYK_MOUSE
NC score	0.061563 (rank : 383)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	358	Target Neighborhood Hits	944	Shared Neighborhood Hits	71
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_MOUSE
NC score	0.061463 (rank : 384)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	358	Target Neighborhood Hits	905	Shared Neighborhood Hits	64
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

SRRM1_MOUSE
NC score	0.061036 (rank : 385)	θ value	6.88961 (rank : 321)
Query Neighborhood Hits	358	Target Neighborhood Hits	966	Shared Neighborhood Hits	110
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

PKHG4_HUMAN
NC score	0.060795 (rank : 386)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	358	Target Neighborhood Hits	200	Shared Neighborhood Hits	24
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

TRIO_HUMAN
NC score	0.060755 (rank : 387)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	358	Target Neighborhood Hits	1580	Shared Neighborhood Hits	108
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZAP70_HUMAN
NC score	0.060723 (rank : 388)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	358	Target Neighborhood Hits	893	Shared Neighborhood Hits	63
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

PRR12_HUMAN
NC score	0.060604 (rank : 389)	θ value	5.27518 (rank : 290)
Query Neighborhood Hits	358	Target Neighborhood Hits	460	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

OPHN1_HUMAN
NC score	0.060291 (rank : 390)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	358	Target Neighborhood Hits	161	Shared Neighborhood Hits	22
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

DOCK3_MOUSE
NC score	0.060283 (rank : 391)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	358	Target Neighborhood Hits	93	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

NRAP_MOUSE
NC score	0.060222 (rank : 392)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	358	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

SH23A_HUMAN
NC score	0.060173 (rank : 393)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	358	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

MNT_HUMAN
NC score	0.060150 (rank : 394)	θ value	4.03905 (rank : 271)
Query Neighborhood Hits	358	Target Neighborhood Hits	496	Shared Neighborhood Hits	66
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCOA6_MOUSE
NC score	0.060148 (rank : 395)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	358	Target Neighborhood Hits	1076	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

KSYK_HUMAN
NC score	0.060144 (rank : 396)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	358	Target Neighborhood Hits	901	Shared Neighborhood Hits	63
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

HSH2D_MOUSE
NC score	0.059977 (rank : 397)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	358	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MYO9B_HUMAN
NC score	0.059771 (rank : 398)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	358	Target Neighborhood Hits	641	Shared Neighborhood Hits	71
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SET1A_HUMAN
NC score	0.059729 (rank : 399)	θ value	1.06291 (rank : 211)
Query Neighborhood Hits	358	Target Neighborhood Hits	690	Shared Neighborhood Hits	63
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

FA47B_HUMAN
NC score	0.059705 (rank : 400)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	358	Target Neighborhood Hits	431	Shared Neighborhood Hits	89
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MLL2_HUMAN
NC score	0.059681 (rank : 401)	θ value	0.813845 (rank : 199)
Query Neighborhood Hits	358	Target Neighborhood Hits	1788	Shared Neighborhood Hits	122
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MAGE1_HUMAN
NC score	0.059656 (rank : 402)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	358	Target Neighborhood Hits	1389	Shared Neighborhood Hits	141
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

FARP2_HUMAN
NC score	0.059547 (rank : 403)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	358	Target Neighborhood Hits	240	Shared Neighborhood Hits	33
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ATN1_HUMAN
NC score	0.059494 (rank : 404)	θ value	6.88961 (rank : 302)
Query Neighborhood Hits	358	Target Neighborhood Hits	676	Shared Neighborhood Hits	71
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

NRAP_HUMAN
NC score	0.059350 (rank : 405)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	358	Target Neighborhood Hits	159	Shared Neighborhood Hits	9
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

FARP1_HUMAN
NC score	0.058648 (rank : 406)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	358	Target Neighborhood Hits	241	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

IWS1_HUMAN
NC score	0.058531 (rank : 407)	θ value	0.0252991 (rank : 128)
Query Neighborhood Hits	358	Target Neighborhood Hits	1241	Shared Neighborhood Hits	91
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MINT_MOUSE
NC score	0.058105 (rank : 408)	θ value	5.27518 (rank : 286)
Query Neighborhood Hits	358	Target Neighborhood Hits	1514	Shared Neighborhood Hits	152
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

TEX14_HUMAN
NC score	0.057855 (rank : 409)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	358	Target Neighborhood Hits	1103	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

REPS2_HUMAN
NC score	0.057848 (rank : 410)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	358	Target Neighborhood Hits	131	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

HRX_HUMAN
NC score	0.057706 (rank : 411)	θ value	0.21417 (rank : 164)
Query Neighborhood Hits	358	Target Neighborhood Hits	825	Shared Neighborhood Hits	79
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

BCL9_HUMAN
NC score	0.057387 (rank : 412)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	358	Target Neighborhood Hits	1008	Shared Neighborhood Hits	124
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

WASF1_HUMAN
NC score	0.057087 (rank : 413)	θ value	0.0563607 (rank : 140)
Query Neighborhood Hits	358	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

TEX14_MOUSE
NC score	0.057054 (rank : 414)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	358	Target Neighborhood Hits	1333	Shared Neighborhood Hits	72
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

OPHN1_MOUSE
NC score	0.056965 (rank : 415)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	358	Target Neighborhood Hits	174	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

WASF1_MOUSE
NC score	0.056933 (rank : 416)	θ value	0.0563607 (rank : 141)
Query Neighborhood Hits	358	Target Neighborhood Hits	261	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

PCLO_MOUSE
NC score	0.056716 (rank : 417)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	358	Target Neighborhood Hits	2275	Shared Neighborhood Hits	180
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SELPL_MOUSE
NC score	0.056534 (rank : 418)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	358	Target Neighborhood Hits	588	Shared Neighborhood Hits	95
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

DOCK3_HUMAN
NC score	0.056285 (rank : 419)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	358	Target Neighborhood Hits	87	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

FA47A_HUMAN
NC score	0.056278 (rank : 420)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	358	Target Neighborhood Hits	451	Shared Neighborhood Hits	83
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

GSCR1_HUMAN
NC score	0.055993 (rank : 421)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	358	Target Neighborhood Hits	674	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MLL3_MOUSE
NC score	0.055661 (rank : 422)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	358	Target Neighborhood Hits	1399	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

ILK_MOUSE
NC score	0.055569 (rank : 423)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	358	Target Neighborhood Hits	858	Shared Neighborhood Hits	53
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

BSN_MOUSE
NC score	0.055522 (rank : 424)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	358	Target Neighborhood Hits	2057	Shared Neighborhood Hits	156
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

ILK1_HUMAN
NC score	0.055316 (rank : 425)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	358	Target Neighborhood Hits	857	Shared Neighborhood Hits	53
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
NC score	0.055262 (rank : 426)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	358	Target Neighborhood Hits	848	Shared Neighborhood Hits	53
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

FGD6_HUMAN
NC score	0.055116 (rank : 427)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	358	Target Neighborhood Hits	237	Shared Neighborhood Hits	25
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

MYO9B_MOUSE
NC score	0.054926 (rank : 428)	θ value	8.99809 (rank : 343)
Query Neighborhood Hits	358	Target Neighborhood Hits	311	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

LAD1_HUMAN
NC score	0.054693 (rank : 429)	θ value	4.03905 (rank : 270)
Query Neighborhood Hits	358	Target Neighborhood Hits	441	Shared Neighborhood Hits	61
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

RHG25_HUMAN
NC score	0.054350 (rank : 430)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	358	Target Neighborhood Hits	550	Shared Neighborhood Hits	32
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CK024_HUMAN
NC score	0.054332 (rank : 431)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	358	Target Neighborhood Hits	408	Shared Neighborhood Hits	78
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

RTN4_MOUSE
NC score	0.054226 (rank : 432)	θ value	0.813845 (rank : 202)
Query Neighborhood Hits	358	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

PRG4_HUMAN
NC score	0.054130 (rank : 433)	θ value	1.06291 (rank : 207)
Query Neighborhood Hits	358	Target Neighborhood Hits	764	Shared Neighborhood Hits	77
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

HGS_MOUSE
NC score	0.053920 (rank : 434)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	358	Target Neighborhood Hits	589	Shared Neighborhood Hits	58
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

REPS2_MOUSE
NC score	0.053912 (rank : 435)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	358	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

TENS4_MOUSE
NC score	0.053883 (rank : 436)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	358	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

MPP5_HUMAN
NC score	0.053862 (rank : 437)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	358	Target Neighborhood Hits	231	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

WASF2_MOUSE
NC score	0.053439 (rank : 438)	θ value	1.06291 (rank : 212)
Query Neighborhood Hits	358	Target Neighborhood Hits	315	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

SRRM2_HUMAN
NC score	0.053200 (rank : 439)	θ value	6.88961 (rank : 322)
Query Neighborhood Hits	358	Target Neighborhood Hits	1296	Shared Neighborhood Hits	99
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

MYO15_HUMAN
NC score	0.053128 (rank : 440)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	358	Target Neighborhood Hits	671	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MIA2_MOUSE
NC score	0.053101 (rank : 441)	θ value	1.81305 (rank : 237)
Query Neighborhood Hits	358	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MPP5_MOUSE
NC score	0.053004 (rank : 442)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	358	Target Neighborhood Hits	226	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SRRM2_MOUSE
NC score	0.052888 (rank : 443)	θ value	6.88961 (rank : 323)
Query Neighborhood Hits	358	Target Neighborhood Hits	1470	Shared Neighborhood Hits	126
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SOS2_HUMAN
NC score	0.052876 (rank : 444)	θ value	0.279714 (rank : 172)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	26
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

MYO15_MOUSE
NC score	0.052467 (rank : 445)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	358	Target Neighborhood Hits	467	Shared Neighborhood Hits	97
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PRP2_MOUSE
NC score	0.052140 (rank : 446)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	358	Target Neighborhood Hits	347	Shared Neighborhood Hits	42
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

HGS_HUMAN
NC score	0.052018 (rank : 447)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	358	Target Neighborhood Hits	517	Shared Neighborhood Hits	45
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

TXND2_HUMAN
NC score	0.051894 (rank : 448)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	358	Target Neighborhood Hits	793	Shared Neighborhood Hits	86
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

SRRM1_HUMAN
NC score	0.051774 (rank : 449)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	358	Target Neighborhood Hits	690	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

BRD8_MOUSE
NC score	0.051188 (rank : 450)	θ value	0.163984 (rank : 149)
Query Neighborhood Hits	358	Target Neighborhood Hits	422	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

SH24A_MOUSE
NC score	0.051095 (rank : 451)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	358	Target Neighborhood Hits	326	Shared Neighborhood Hits	36
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SOCS6_HUMAN
NC score	0.050968 (rank : 452)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	358	Target Neighborhood Hits	126	Shared Neighborhood Hits	32
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.050955 (rank : 453)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	358	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FES_HUMAN
NC score	0.050643 (rank : 454)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	358	Target Neighborhood Hits	978	Shared Neighborhood Hits	60
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TENS4_HUMAN
NC score	0.050540 (rank : 455)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	358	Target Neighborhood Hits	214	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

ENAH_MOUSE
NC score	0.050276 (rank : 456)	θ value	1.81305 (rank : 235)
Query Neighborhood Hits	358	Target Neighborhood Hits	919	Shared Neighborhood Hits	81
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

K1802_MOUSE
NC score	0.050216 (rank : 457)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	358	Target Neighborhood Hits	1596	Shared Neighborhood Hits	145
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NFH_MOUSE
NC score	0.049968 (rank : 458)	θ value	0.62314 (rank : 188)
Query Neighborhood Hits	358	Target Neighborhood Hits	2247	Shared Neighborhood Hits	158
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CSKI1_HUMAN
NC score	0.049517 (rank : 459)	θ value	0.47712 (rank : 181)
Query Neighborhood Hits	358	Target Neighborhood Hits	997	Shared Neighborhood Hits	127
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CCNK_MOUSE
NC score	0.049443 (rank : 460)	θ value	1.38821 (rank : 215)
Query Neighborhood Hits	358	Target Neighborhood Hits	350	Shared Neighborhood Hits	47
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

ANR11_HUMAN
NC score	0.048223 (rank : 461)	θ value	1.38821 (rank : 213)
Query Neighborhood Hits	358	Target Neighborhood Hits	1289	Shared Neighborhood Hits	104
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

WNK2_HUMAN
NC score	0.048018 (rank : 462)	θ value	2.36792 (rank : 251)
Query Neighborhood Hits	358	Target Neighborhood Hits	1407	Shared Neighborhood Hits	118
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

PRG4_MOUSE
NC score	0.047554 (rank : 463)	θ value	1.38821 (rank : 224)
Query Neighborhood Hits	358	Target Neighborhood Hits	624	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SELV_HUMAN
NC score	0.047294 (rank : 464)	θ value	1.06291 (rank : 210)
Query Neighborhood Hits	358	Target Neighborhood Hits	118	Shared Neighborhood Hits	24
SwissProt Accessions	P59797	Gene names	SELV
Domain Architecture	No domain graphic available
Description	Selenoprotein V.

CIC_HUMAN
NC score	0.046586 (rank : 465)	θ value	8.99809 (rank : 331)
Query Neighborhood Hits	358	Target Neighborhood Hits	992	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NCOR2_HUMAN
NC score	0.045842 (rank : 466)	θ value	3.0926 (rank : 258)
Query Neighborhood Hits	358	Target Neighborhood Hits	870	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

ANK2_HUMAN
NC score	0.045582 (rank : 467)	θ value	1.81305 (rank : 229)
Query Neighborhood Hits	358	Target Neighborhood Hits	1615	Shared Neighborhood Hits	133
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CO039_MOUSE
NC score	0.045375 (rank : 468)	θ value	5.27518 (rank : 280)
Query Neighborhood Hits	358	Target Neighborhood Hits	445	Shared Neighborhood Hits	85
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

SF3A2_HUMAN
NC score	0.044743 (rank : 469)	θ value	5.27518 (rank : 291)
Query Neighborhood Hits	358	Target Neighborhood Hits	263	Shared Neighborhood Hits	34
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

TM1L1_MOUSE
NC score	0.044068 (rank : 470)	θ value	8.99809 (rank : 357)
Query Neighborhood Hits	358	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q923U0, Q99KE0, Q9D6Y5	Gene names	Tom1l1, Srcasm
Domain Architecture
Description	TOM1-like 1 protein (Target of myb-like 1 protein) (Src-activating and signaling molecule protein).

SYNG_MOUSE
NC score	0.043111 (rank : 471)	θ value	4.03905 (rank : 275)
Query Neighborhood Hits	358	Target Neighborhood Hits	206	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

BAT3_HUMAN
NC score	0.042573 (rank : 472)	θ value	1.38821 (rank : 214)
Query Neighborhood Hits	358	Target Neighborhood Hits	490	Shared Neighborhood Hits	68
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SFPQ_HUMAN
NC score	0.042264 (rank : 473)	θ value	0.163984 (rank : 156)
Query Neighborhood Hits	358	Target Neighborhood Hits	986	Shared Neighborhood Hits	66
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

OGFR_MOUSE
NC score	0.041410 (rank : 474)	θ value	8.99809 (rank : 345)
Query Neighborhood Hits	358	Target Neighborhood Hits	584	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

BRD4_MOUSE
NC score	0.040464 (rank : 475)	θ value	1.81305 (rank : 233)
Query Neighborhood Hits	358	Target Neighborhood Hits	845	Shared Neighborhood Hits	66
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

SYNJ1_MOUSE
NC score	0.040433 (rank : 476)	θ value	2.36792 (rank : 250)
Query Neighborhood Hits	358	Target Neighborhood Hits	516	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

MY18B_HUMAN
NC score	0.040299 (rank : 477)	θ value	1.81305 (rank : 239)
Query Neighborhood Hits	358	Target Neighborhood Hits	1299	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

SEPT9_HUMAN
NC score	0.040170 (rank : 478)	θ value	8.99809 (rank : 349)
Query Neighborhood Hits	358	Target Neighborhood Hits	706	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

CTDP1_HUMAN
NC score	0.040046 (rank : 479)	θ value	4.03905 (rank : 268)
Query Neighborhood Hits	358	Target Neighborhood Hits	416	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DLG4_HUMAN
NC score	0.040035 (rank : 480)	θ value	8.99809 (rank : 336)
Query Neighborhood Hits	358	Target Neighborhood Hits	286	Shared Neighborhood Hits	64
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

FMNL_MOUSE
NC score	0.040002 (rank : 481)	θ value	0.62314 (rank : 187)
Query Neighborhood Hits	358	Target Neighborhood Hits	428	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

BRD4_HUMAN
NC score	0.039856 (rank : 482)	θ value	8.99809 (rank : 330)
Query Neighborhood Hits	358	Target Neighborhood Hits	851	Shared Neighborhood Hits	80
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD8_HUMAN
NC score	0.039656 (rank : 483)	θ value	0.813845 (rank : 195)
Query Neighborhood Hits	358	Target Neighborhood Hits	292	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

FMN1A_MOUSE
NC score	0.039633 (rank : 484)	θ value	1.38821 (rank : 218)
Query Neighborhood Hits	358	Target Neighborhood Hits	423	Shared Neighborhood Hits	47
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

EP300_HUMAN
NC score	0.039474 (rank : 485)	θ value	5.27518 (rank : 284)
Query Neighborhood Hits	358	Target Neighborhood Hits	821	Shared Neighborhood Hits	83
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FMN1B_MOUSE
NC score	0.039319 (rank : 486)	θ value	1.38821 (rank : 219)
Query Neighborhood Hits	358	Target Neighborhood Hits	447	Shared Neighborhood Hits	50
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

AB1IP_MOUSE
NC score	0.038753 (rank : 487)	θ value	0.813845 (rank : 191)
Query Neighborhood Hits	358	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

DGKK_HUMAN
NC score	0.038236 (rank : 488)	θ value	8.99809 (rank : 335)
Query Neighborhood Hits	358	Target Neighborhood Hits	378	Shared Neighborhood Hits	45
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

AL2S4_MOUSE
NC score	0.037786 (rank : 489)	θ value	6.88961 (rank : 298)
Query Neighborhood Hits	358	Target Neighborhood Hits	193	Shared Neighborhood Hits	44
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

RBM12_MOUSE
NC score	0.037638 (rank : 490)	θ value	0.813845 (rank : 201)
Query Neighborhood Hits	358	Target Neighborhood Hits	313	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

SFPQ_MOUSE
NC score	0.037539 (rank : 491)	θ value	8.99809 (rank : 350)
Query Neighborhood Hits	358	Target Neighborhood Hits	958	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

CNTRB_MOUSE
NC score	0.037455 (rank : 492)	θ value	3.0926 (rank : 254)
Query Neighborhood Hits	358	Target Neighborhood Hits	1029	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

RTN4_HUMAN
NC score	0.037345 (rank : 493)	θ value	6.88961 (rank : 317)
Query Neighborhood Hits	358	Target Neighborhood Hits	357	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

DLG4_MOUSE
NC score	0.036793 (rank : 494)	θ value	6.88961 (rank : 306)
Query Neighborhood Hits	358	Target Neighborhood Hits	282	Shared Neighborhood Hits	61
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DGCR8_HUMAN
NC score	0.035635 (rank : 495)	θ value	5.27518 (rank : 281)
Query Neighborhood Hits	358	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

RPGF1_HUMAN
NC score	0.035107 (rank : 496)	θ value	3.0926 (rank : 261)
Query Neighborhood Hits	358	Target Neighborhood Hits	262	Shared Neighborhood Hits	56
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

WNK1_MOUSE
NC score	0.034921 (rank : 497)	θ value	3.0926 (rank : 264)
Query Neighborhood Hits	358	Target Neighborhood Hits	1179	Shared Neighborhood Hits	82
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

AB1IP_HUMAN
NC score	0.034350 (rank : 498)	θ value	6.88961 (rank : 297)
Query Neighborhood Hits	358	Target Neighborhood Hits	213	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

GGA2_HUMAN
NC score	0.034206 (rank : 499)	θ value	4.03905 (rank : 269)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

WNK1_HUMAN
NC score	0.034043 (rank : 500)	θ value	6.88961 (rank : 326)
Query Neighborhood Hits	358	Target Neighborhood Hits	1158	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

MUC2_HUMAN
NC score	0.033850 (rank : 501)	θ value	3.0926 (rank : 257)
Query Neighborhood Hits	358	Target Neighborhood Hits	906	Shared Neighborhood Hits	60
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SETBP_HUMAN
NC score	0.033561 (rank : 502)	θ value	2.36792 (rank : 249)
Query Neighborhood Hits	358	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

DNJC8_MOUSE
NC score	0.033320 (rank : 503)	θ value	5.27518 (rank : 283)
Query Neighborhood Hits	358	Target Neighborhood Hits	392	Shared Neighborhood Hits	25
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

AAK1_HUMAN
NC score	0.033307 (rank : 504)	θ value	4.03905 (rank : 265)
Query Neighborhood Hits	358	Target Neighborhood Hits	1077	Shared Neighborhood Hits	99
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

TESK2_HUMAN
NC score	0.033186 (rank : 505)	θ value	8.99809 (rank : 356)
Query Neighborhood Hits	358	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

SETD8_MOUSE
NC score	0.032183 (rank : 506)	θ value	1.81305 (rank : 240)
Query Neighborhood Hits	358	Target Neighborhood Hits	131	Shared Neighborhood Hits	19
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

DNJC8_HUMAN
NC score	0.031853 (rank : 507)	θ value	5.27518 (rank : 282)
Query Neighborhood Hits	358	Target Neighborhood Hits	380	Shared Neighborhood Hits	24
SwissProt Accessions	O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067	Gene names	DNAJC8, SPF31
Domain Architecture
Description	DnaJ homolog subfamily C member 8 (Splicing protein spf31).

TACC2_HUMAN
NC score	0.031251 (rank : 508)	θ value	8.99809 (rank : 355)
Query Neighborhood Hits	358	Target Neighborhood Hits	856	Shared Neighborhood Hits	67
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

MINK1_HUMAN
NC score	0.030612 (rank : 509)	θ value	2.36792 (rank : 247)
Query Neighborhood Hits	358	Target Neighborhood Hits	1477	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
NC score	0.030584 (rank : 510)	θ value	1.81305 (rank : 238)
Query Neighborhood Hits	358	Target Neighborhood Hits	1451	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

WNK4_HUMAN
NC score	0.030088 (rank : 511)	θ value	4.03905 (rank : 276)
Query Neighborhood Hits	358	Target Neighborhood Hits	1043	Shared Neighborhood Hits	73
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

IF35_MOUSE
NC score	0.029741 (rank : 512)	θ value	8.99809 (rank : 340)
Query Neighborhood Hits	358	Target Neighborhood Hits	210	Shared Neighborhood Hits	34
SwissProt Accessions	Q9DCH4	Gene names	Eif3s5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

AKA12_HUMAN
NC score	0.029598 (rank : 513)	θ value	4.03905 (rank : 267)
Query Neighborhood Hits	358	Target Neighborhood Hits	825	Shared Neighborhood Hits	50
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

BCL7C_MOUSE
NC score	0.029142 (rank : 514)	θ value	1.81305 (rank : 232)
Query Neighborhood Hits	358	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

IF35_HUMAN
NC score	0.028576 (rank : 515)	θ value	1.81305 (rank : 236)
Query Neighborhood Hits	358	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IF39_HUMAN
NC score	0.028562 (rank : 516)	θ value	5.27518 (rank : 285)
Query Neighborhood Hits	358	Target Neighborhood Hits	187	Shared Neighborhood Hits	22
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

PI5PA_MOUSE
NC score	0.028480 (rank : 517)	θ value	3.0926 (rank : 260)
Query Neighborhood Hits	358	Target Neighborhood Hits	331	Shared Neighborhood Hits	51
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

RBM12_HUMAN
NC score	0.028273 (rank : 518)	θ value	6.88961 (rank : 315)
Query Neighborhood Hits	358	Target Neighborhood Hits	298	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

ANTR1_MOUSE
NC score	0.027508 (rank : 519)	θ value	0.813845 (rank : 193)
Query Neighborhood Hits	358	Target Neighborhood Hits	143	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

ZAN_HUMAN
NC score	0.027240 (rank : 520)	θ value	5.27518 (rank : 293)
Query Neighborhood Hits	358	Target Neighborhood Hits	679	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ADDB_MOUSE
NC score	0.026983 (rank : 521)	θ value	4.03905 (rank : 266)
Query Neighborhood Hits	358	Target Neighborhood Hits	574	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

SPEG_MOUSE
NC score	0.026921 (rank : 522)	θ value	5.27518 (rank : 292)
Query Neighborhood Hits	358	Target Neighborhood Hits	1959	Shared Neighborhood Hits	132
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PDC6I_HUMAN
NC score	0.026384 (rank : 523)	θ value	5.27518 (rank : 288)
Query Neighborhood Hits	358	Target Neighborhood Hits	278	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

ANK3_HUMAN
NC score	0.025590 (rank : 524)	θ value	2.36792 (rank : 243)
Query Neighborhood Hits	358	Target Neighborhood Hits	853	Shared Neighborhood Hits	62
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

FBLI1_HUMAN
NC score	0.024679 (rank : 525)	θ value	0.47712 (rank : 183)
Query Neighborhood Hits	358	Target Neighborhood Hits	200	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WUP2, Q5VVE0, Q5VVE1, Q8IX23, Q96T00, Q9UFD6	Gene names	FBLIM1, FBLP1
Domain Architecture
Description	Filamin-binding LIM protein 1 (Filamin-binding LIM protein 1) (FBLP-1) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) (Migfilin).

M3K1_MOUSE
NC score	0.024612 (rank : 526)	θ value	2.36792 (rank : 246)
Query Neighborhood Hits	358	Target Neighborhood Hits	952	Shared Neighborhood Hits	47
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

TITIN_HUMAN
NC score	0.024607 (rank : 527)	θ value	0.125558 (rank : 148)
Query Neighborhood Hits	358	Target Neighborhood Hits	2923	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

FBLI1_MOUSE
NC score	0.024258 (rank : 528)	θ value	0.813845 (rank : 196)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

SN1L2_MOUSE
NC score	0.024024 (rank : 529)	θ value	6.88961 (rank : 320)
Query Neighborhood Hits	358	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

DOK2_HUMAN
NC score	0.023712 (rank : 530)	θ value	0.365318 (rank : 175)
Query Neighborhood Hits	358	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O60496	Gene names	DOK2
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)).

MICA1_HUMAN
NC score	0.023435 (rank : 531)	θ value	0.813845 (rank : 198)
Query Neighborhood Hits	358	Target Neighborhood Hits	279	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

SNX19_HUMAN
NC score	0.023323 (rank : 532)	θ value	3.0926 (rank : 263)
Query Neighborhood Hits	358	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

BARD1_MOUSE
NC score	0.022612 (rank : 533)	θ value	6.88961 (rank : 303)
Query Neighborhood Hits	358	Target Neighborhood Hits	411	Shared Neighborhood Hits	19
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

WBS14_HUMAN
NC score	0.022472 (rank : 534)	θ value	6.88961 (rank : 325)
Query Neighborhood Hits	358	Target Neighborhood Hits	273	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

PTN23_HUMAN
NC score	0.022106 (rank : 535)	θ value	6.88961 (rank : 314)
Query Neighborhood Hits	358	Target Neighborhood Hits	646	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

CBLB_HUMAN
NC score	0.021949 (rank : 536)	θ value	0.47712 (rank : 180)
Query Neighborhood Hits	358	Target Neighborhood Hits	261	Shared Neighborhood Hits	16
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

PTN22_MOUSE
NC score	0.021794 (rank : 537)	θ value	0.0563607 (rank : 138)
Query Neighborhood Hits	358	Target Neighborhood Hits	179	Shared Neighborhood Hits	23
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

BCL7C_HUMAN
NC score	0.021347 (rank : 538)	θ value	6.88961 (rank : 304)
Query Neighborhood Hits	358	Target Neighborhood Hits	57	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WUZ0, O43770, Q6PD89	Gene names	BCL7C
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C.

PDC6I_MOUSE
NC score	0.021322 (rank : 539)	θ value	5.27518 (rank : 289)
Query Neighborhood Hits	358	Target Neighborhood Hits	275	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

ANTOL_HUMAN
NC score	0.021268 (rank : 540)	θ value	2.36792 (rank : 244)
Query Neighborhood Hits	358	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

K0562_HUMAN
NC score	0.021215 (rank : 541)	θ value	2.36792 (rank : 245)
Query Neighborhood Hits	358	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

EP400_HUMAN
NC score	0.021041 (rank : 542)	θ value	1.38821 (rank : 217)
Query Neighborhood Hits	358	Target Neighborhood Hits	556	Shared Neighborhood Hits	52
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

SIA7A_MOUSE
NC score	0.020501 (rank : 543)	θ value	1.38821 (rank : 226)
Query Neighborhood Hits	358	Target Neighborhood Hits	203	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

BPL1_HUMAN
NC score	0.020374 (rank : 544)	θ value	3.0926 (rank : 253)
Query Neighborhood Hits	358	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P50747, Q99451	Gene names	HLCS
Domain Architecture
Description	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin-- [acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)].

RCOR2_HUMAN
NC score	0.019704 (rank : 545)	θ value	4.03905 (rank : 273)
Query Neighborhood Hits	358	Target Neighborhood Hits	114	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IZ40, Q96FP3	Gene names	RCOR2
Domain Architecture	No domain graphic available
Description	REST corepressor 2.

SV2B_MOUSE
NC score	0.019111 (rank : 546)	θ value	8.99809 (rank : 353)
Query Neighborhood Hits	358	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

CS007_HUMAN
NC score	0.019072 (rank : 547)	θ value	8.99809 (rank : 334)
Query Neighborhood Hits	358	Target Neighborhood Hits	401	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

TNR8_HUMAN
NC score	0.018997 (rank : 548)	θ value	1.38821 (rank : 227)
Query Neighborhood Hits	358	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

PAG1_HUMAN
NC score	0.018866 (rank : 549)	θ value	6.88961 (rank : 313)
Query Neighborhood Hits	358	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

PKN3_HUMAN
NC score	0.018388 (rank : 550)	θ value	4.03905 (rank : 272)
Query Neighborhood Hits	358	Target Neighborhood Hits	893	Shared Neighborhood Hits	49
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ANR40_MOUSE
NC score	0.018371 (rank : 551)	θ value	6.88961 (rank : 299)
Query Neighborhood Hits	358	Target Neighborhood Hits	228	Shared Neighborhood Hits	17
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

CBLB_MOUSE
NC score	0.017781 (rank : 552)	θ value	5.27518 (rank : 279)
Query Neighborhood Hits	358	Target Neighborhood Hits	277	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

RECQ5_HUMAN
NC score	0.017398 (rank : 553)	θ value	8.99809 (rank : 348)
Query Neighborhood Hits	358	Target Neighborhood Hits	390	Shared Neighborhood Hits	55
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SYNJ2_MOUSE
NC score	0.016338 (rank : 554)	θ value	8.99809 (rank : 354)
Query Neighborhood Hits	358	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SMAD9_HUMAN
NC score	0.015990 (rank : 555)	θ value	0.21417 (rank : 168)
Query Neighborhood Hits	358	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

SMCA4_HUMAN
NC score	0.015738 (rank : 556)	θ value	6.88961 (rank : 319)
Query Neighborhood Hits	358	Target Neighborhood Hits	597	Shared Neighborhood Hits	53
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

PRDM2_HUMAN
NC score	0.015516 (rank : 557)	θ value	0.365318 (rank : 177)
Query Neighborhood Hits	358	Target Neighborhood Hits	1135	Shared Neighborhood Hits	65
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PTN22_HUMAN
NC score	0.014954 (rank : 558)	θ value	1.38821 (rank : 225)
Query Neighborhood Hits	358	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

ERN2_HUMAN
NC score	0.014724 (rank : 559)	θ value	8.99809 (rank : 337)
Query Neighborhood Hits	358	Target Neighborhood Hits	844	Shared Neighborhood Hits	43
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CPSF7_MOUSE
NC score	0.014017 (rank : 560)	θ value	8.99809 (rank : 333)
Query Neighborhood Hits	358	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BTV2, Q3TNF1, Q8BKE7, Q8CFS8	Gene names	Cpsf7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7.

CPSF7_HUMAN
NC score	0.013954 (rank : 561)	θ value	8.99809 (rank : 332)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

LRC56_HUMAN
NC score	0.012278 (rank : 562)	θ value	6.88961 (rank : 309)
Query Neighborhood Hits	358	Target Neighborhood Hits	165	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

ATF6B_HUMAN
NC score	0.011812 (rank : 563)	θ value	6.88961 (rank : 301)
Query Neighborhood Hits	358	Target Neighborhood Hits	122	Shared Neighborhood Hits	17
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

MOT8_HUMAN
NC score	0.009700 (rank : 564)	θ value	6.88961 (rank : 310)
Query Neighborhood Hits	358	Target Neighborhood Hits	92	Shared Neighborhood Hits	11
SwissProt Accessions	P36021, Q7Z797	Gene names	SLC16A2, MCT8, XPCT
Domain Architecture	No domain graphic available
Description	Monocarboxylate transporter 8 (MCT 8) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter).

GP1BA_HUMAN
NC score	0.009585 (rank : 565)	θ value	1.38821 (rank : 220)
Query Neighborhood Hits	358	Target Neighborhood Hits	407	Shared Neighborhood Hits	24
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

APCD1_MOUSE
NC score	0.008156 (rank : 566)	θ value	8.99809 (rank : 328)
Query Neighborhood Hits	358	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U128, Q3TA99	Gene names	Apcdd1, Drapc1
Domain Architecture	No domain graphic available
Description	Protein APCDD1 precursor (Adenomatosis polyposis coli down-regulated 1 protein homolog).

LPIN3_HUMAN
NC score	0.007446 (rank : 567)	θ value	8.99809 (rank : 341)
Query Neighborhood Hits	358	Target Neighborhood Hits	92	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

SREC2_HUMAN
NC score	0.005230 (rank : 568)	θ value	8.99809 (rank : 351)
Query Neighborhood Hits	358	Target Neighborhood Hits	645	Shared Neighborhood Hits	31
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

FOXB1_MOUSE
NC score	0.004645 (rank : 569)	θ value	3.0926 (rank : 256)
Query Neighborhood Hits	358	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q64732, O08753	Gene names	Foxb1, Fkh5, Foxb1a, Foxb1b, Mf3
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

FOXB1_HUMAN
NC score	0.004570 (rank : 570)	θ value	3.0926 (rank : 255)
Query Neighborhood Hits	358	Target Neighborhood Hits	121	Shared Neighborhood Hits	6
SwissProt Accessions	Q99853, O60652, O75917	Gene names	FOXB1, FKH5
Domain Architecture
Description	Forkhead box protein B1 (Transcription factor FKH-5).

BAI1_HUMAN
NC score	0.004183 (rank : 571)	θ value	3.0926 (rank : 252)
Query Neighborhood Hits	358	Target Neighborhood Hits	375	Shared Neighborhood Hits	25
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

MORC4_MOUSE
NC score	0.003510 (rank : 572)	θ value	8.99809 (rank : 342)
Query Neighborhood Hits	358	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BMD7, Q4KMM6, Q8BX95, Q9CS96	Gene names	Morc4, Zcwcc2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

PI3R4_MOUSE
NC score	0.002404 (rank : 573)	θ value	8.99809 (rank : 346)
Query Neighborhood Hits	358	Target Neighborhood Hits	535	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

HXA3_HUMAN
NC score	0.002292 (rank : 574)	θ value	6.88961 (rank : 308)
Query Neighborhood Hits	358	Target Neighborhood Hits	535	Shared Neighborhood Hits	36
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

ATBF1_HUMAN
NC score	0.001511 (rank : 575)	θ value	6.88961 (rank : 300)
Query Neighborhood Hits	358	Target Neighborhood Hits	1547	Shared Neighborhood Hits	61
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

FBLN2_MOUSE
NC score	0.000485 (rank : 576)	θ value	8.99809 (rank : 339)
Query Neighborhood Hits	358	Target Neighborhood Hits	505	Shared Neighborhood Hits	34
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

ZBTB5_MOUSE
NC score	-0.001080 (rank : 577)	θ value	0.365318 (rank : 179)
Query Neighborhood Hits	358	Target Neighborhood Hits	801	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG0, Q3TVR7, Q6GV09, Q8BIB5	Gene names	Zbtb5, Kiaa0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5 (Transcription factor ZNF-POZ).

ZN219_HUMAN
NC score	-0.001959 (rank : 578)	θ value	4.03905 (rank : 277)
Query Neighborhood Hits	358	Target Neighborhood Hits	876	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

ZN688_HUMAN
NC score	-0.004420 (rank : 579)	θ value	8.99809 (rank : 358)
Query Neighborhood Hits	358	Target Neighborhood Hits	873	Shared Neighborhood Hits	49
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

ZN509_MOUSE
NC score	-0.005319 (rank : 580)	θ value	1.38821 (rank : 228)
Query Neighborhood Hits	358	Target Neighborhood Hits	990	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

MTF1_MOUSE
NC score	-0.005353 (rank : 581)	θ value	6.88961 (rank : 311)
Query Neighborhood Hits	358	Target Neighborhood Hits	785	Shared Neighborhood Hits	26
SwissProt Accessions	Q07243	Gene names	Mtf1, Mtf-1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

ZN579_MOUSE
NC score	-0.005454 (rank : 582)	θ value	5.27518 (rank : 296)
Query Neighborhood Hits	358	Target Neighborhood Hits	719	Shared Neighborhood Hits	17
SwissProt Accessions	Q80VM4	Gene names	Znf579, Zfp579
Domain Architecture	No domain graphic available
Description	Zinc finger protein 579.

ZN579_HUMAN
NC score	-0.005585 (rank : 583)	θ value	5.27518 (rank : 295)
Query Neighborhood Hits	358	Target Neighborhood Hits	726	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NAF0	Gene names	ZNF579
Domain Architecture	No domain graphic available
Description	Zinc finger protein 579.

ZN406_HUMAN
NC score	-0.006308 (rank : 584)	θ value	6.88961 (rank : 327)
Query Neighborhood Hits	358	Target Neighborhood Hits	794	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

ZN500_HUMAN
NC score	-0.006504 (rank : 585)	θ value	5.27518 (rank : 294)
Query Neighborhood Hits	358	Target Neighborhood Hits	746	Shared Neighborhood Hits	17
SwissProt Accessions	O60304, Q96CQ8, Q9BTG0	Gene names	ZNF500, KIAA0557
Domain Architecture
Description	Zinc finger protein 500.

ZN553_HUMAN
NC score	-0.006663 (rank : 586)	θ value	4.03905 (rank : 278)
Query Neighborhood Hits	358	Target Neighborhood Hits	760	Shared Neighborhood Hits	16
SwissProt Accessions	Q96MX3, Q4G0R3, Q69YP3, Q96IL9	Gene names	ZNF553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.