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Network neighborhood for query Sequence : RUSC1_MOUSE

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RUSC1_MOUSE
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RUSC1_HUMAN
θ value	0 (rank : 1)	NC score	0.957171 (rank : 2)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	9.83387e-39 (rank : 3)	NC score	0.681593 (rank : 3)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	2.86122e-38 (rank : 4)	NC score	0.657656 (rank : 4)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ITSN1_MOUSE
θ value	1.43324e-05 (rank : 5)	NC score	0.226006 (rank : 79)
Query Neighborhood Hits	206	Target Neighborhood Hits	1669	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
θ value	1.87187e-05 (rank : 6)	NC score	0.224690 (rank : 80)
Query Neighborhood Hits	206	Target Neighborhood Hits	1757	Shared Neighborhood Hits	149
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABI2_HUMAN
θ value	3.19293e-05 (rank : 7)	NC score	0.340951 (rank : 7)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	3.19293e-05 (rank : 8)	NC score	0.345057 (rank : 6)
Query Neighborhood Hits	206	Target Neighborhood Hits	266	Shared Neighborhood Hits	121
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SETBP_HUMAN
θ value	9.29e-05 (rank : 9)	NC score	0.142963 (rank : 117)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SETBP_MOUSE
θ value	0.000158464 (rank : 10)	NC score	0.140771 (rank : 118)
Query Neighborhood Hits	206	Target Neighborhood Hits	352	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

EFS_HUMAN
θ value	0.00020696 (rank : 11)	NC score	0.337763 (rank : 9)
Query Neighborhood Hits	206	Target Neighborhood Hits	348	Shared Neighborhood Hits	123
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.000270298 (rank : 12)	NC score	0.340317 (rank : 8)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	116
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PPIP1_HUMAN
θ value	0.000461057 (rank : 13)	NC score	0.332794 (rank : 11)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ITSN2_HUMAN
θ value	0.00175202 (rank : 14)	NC score	0.229355 (rank : 73)
Query Neighborhood Hits	206	Target Neighborhood Hits	1173	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NEBU_HUMAN
θ value	0.00298849 (rank : 15)	NC score	0.237152 (rank : 67)
Query Neighborhood Hits	206	Target Neighborhood Hits	420	Shared Neighborhood Hits	114
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

PPIP1_MOUSE
θ value	0.00298849 (rank : 16)	NC score	0.311212 (rank : 18)
Query Neighborhood Hits	206	Target Neighborhood Hits	377	Shared Neighborhood Hits	127
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CRKL_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.279453 (rank : 38)
Query Neighborhood Hits	206	Target Neighborhood Hits	313	Shared Neighborhood Hits	123
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

LASP1_HUMAN
θ value	0.00390308 (rank : 18)	NC score	0.293459 (rank : 29)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	107
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.286603 (rank : 32)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	106
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

RHG04_HUMAN
θ value	0.00390308 (rank : 20)	NC score	0.228842 (rank : 75)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

CRKL_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.272789 (rank : 40)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	124
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITSN2_MOUSE
θ value	0.00665767 (rank : 22)	NC score	0.217197 (rank : 85)
Query Neighborhood Hits	206	Target Neighborhood Hits	1371	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SHLB2_HUMAN
θ value	0.00665767 (rank : 23)	NC score	0.241986 (rank : 62)
Query Neighborhood Hits	206	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

GRAP_HUMAN
θ value	0.00869519 (rank : 24)	NC score	0.282775 (rank : 37)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SHLB2_MOUSE
θ value	0.00869519 (rank : 25)	NC score	0.244464 (rank : 60)
Query Neighborhood Hits	206	Target Neighborhood Hits	88	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

HCLS1_MOUSE
θ value	0.0113563 (rank : 26)	NC score	0.324641 (rank : 12)
Query Neighborhood Hits	206	Target Neighborhood Hits	329	Shared Neighborhood Hits	125
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SPTA1_HUMAN
θ value	0.0113563 (rank : 27)	NC score	0.144615 (rank : 116)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	121
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VINEX_MOUSE
θ value	0.0113563 (rank : 28)	NC score	0.322804 (rank : 13)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	127
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DBNL_HUMAN
θ value	0.0148317 (rank : 29)	NC score	0.294138 (rank : 28)
Query Neighborhood Hits	206	Target Neighborhood Hits	244	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.0148317 (rank : 30)	NC score	0.286531 (rank : 33)
Query Neighborhood Hits	206	Target Neighborhood Hits	306	Shared Neighborhood Hits	109
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SRC8_HUMAN
θ value	0.0148317 (rank : 31)	NC score	0.318895 (rank : 14)
Query Neighborhood Hits	206	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.0148317 (rank : 32)	NC score	0.317201 (rank : 15)
Query Neighborhood Hits	206	Target Neighborhood Hits	292	Shared Neighborhood Hits	128
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

GRB2_HUMAN
θ value	0.0193708 (rank : 33)	NC score	0.286787 (rank : 31)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	129
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.0193708 (rank : 34)	NC score	0.286363 (rank : 34)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

EPHB3_MOUSE
θ value	0.0252991 (rank : 35)	NC score	0.039200 (rank : 244)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	34
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

HCLS1_HUMAN
θ value	0.0252991 (rank : 36)	NC score	0.333527 (rank : 10)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	126
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF2_HUMAN
θ value	0.0252991 (rank : 37)	NC score	0.364182 (rank : 5)
Query Neighborhood Hits	206	Target Neighborhood Hits	229	Shared Neighborhood Hits	118
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G3_MOUSE
θ value	0.0252991 (rank : 38)	NC score	0.307112 (rank : 22)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	124
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHLB1_HUMAN
θ value	0.0252991 (rank : 39)	NC score	0.237023 (rank : 69)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

AHI1_MOUSE
θ value	0.0330416 (rank : 40)	NC score	0.227827 (rank : 76)
Query Neighborhood Hits	206	Target Neighborhood Hits	496	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

GRAP2_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.285179 (rank : 36)
Query Neighborhood Hits	206	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	0.0330416 (rank : 42)	NC score	0.291117 (rank : 30)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	130
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCF4_MOUSE
θ value	0.0330416 (rank : 43)	NC score	0.313569 (rank : 16)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	107
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

BCAR1_HUMAN
θ value	0.0431538 (rank : 44)	NC score	0.261603 (rank : 48)
Query Neighborhood Hits	206	Target Neighborhood Hits	554	Shared Neighborhood Hits	130
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.0431538 (rank : 45)	NC score	0.271994 (rank : 41)
Query Neighborhood Hits	206	Target Neighborhood Hits	438	Shared Neighborhood Hits	128
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SHLB1_MOUSE
θ value	0.0431538 (rank : 46)	NC score	0.237052 (rank : 68)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SOX13_HUMAN
θ value	0.0431538 (rank : 47)	NC score	0.035580 (rank : 251)
Query Neighborhood Hits	206	Target Neighborhood Hits	464	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SRGP2_MOUSE
θ value	0.0431538 (rank : 48)	NC score	0.184475 (rank : 93)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	107
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

DNMBP_HUMAN
θ value	0.0563607 (rank : 49)	NC score	0.254447 (rank : 51)
Query Neighborhood Hits	206	Target Neighborhood Hits	413	Shared Neighborhood Hits	132
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MYLK_HUMAN
θ value	0.0563607 (rank : 50)	NC score	0.024156 (rank : 265)
Query Neighborhood Hits	206	Target Neighborhood Hits	1328	Shared Neighborhood Hits	38
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SRGP2_HUMAN
θ value	0.0563607 (rank : 51)	NC score	0.181079 (rank : 96)
Query Neighborhood Hits	206	Target Neighborhood Hits	331	Shared Neighborhood Hits	106
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

VINEX_HUMAN
θ value	0.0563607 (rank : 52)	NC score	0.312243 (rank : 17)
Query Neighborhood Hits	206	Target Neighborhood Hits	270	Shared Neighborhood Hits	127
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI1_MOUSE
θ value	0.0736092 (rank : 53)	NC score	0.308991 (rank : 20)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

BTK_MOUSE
θ value	0.0736092 (rank : 54)	NC score	0.081396 (rank : 166)
Query Neighborhood Hits	206	Target Neighborhood Hits	1017	Shared Neighborhood Hits	117
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

NCF4_HUMAN
θ value	0.0736092 (rank : 55)	NC score	0.306330 (rank : 23)
Query Neighborhood Hits	206	Target Neighborhood Hits	161	Shared Neighborhood Hits	99
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	0.0736092 (rank : 56)	NC score	0.251569 (rank : 53)
Query Neighborhood Hits	206	Target Neighborhood Hits	457	Shared Neighborhood Hits	113
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SH3G2_HUMAN
θ value	0.0736092 (rank : 57)	NC score	0.303624 (rank : 24)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	126
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	0.0961366 (rank : 58)	NC score	0.302888 (rank : 25)
Query Neighborhood Hits	206	Target Neighborhood Hits	222	Shared Neighborhood Hits	122
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ABI1_HUMAN
θ value	0.125558 (rank : 59)	NC score	0.298732 (rank : 27)
Query Neighborhood Hits	206	Target Neighborhood Hits	257	Shared Neighborhood Hits	117
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

B4GN4_HUMAN
θ value	0.125558 (rank : 60)	NC score	0.048042 (rank : 238)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q76KP1, Q96LV2	Gene names	B4GALNT4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

IASPP_HUMAN
θ value	0.125558 (rank : 61)	NC score	0.185081 (rank : 92)
Query Neighborhood Hits	206	Target Neighborhood Hits	688	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MATK_HUMAN
θ value	0.125558 (rank : 62)	NC score	0.053384 (rank : 231)
Query Neighborhood Hits	206	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

RGS3_HUMAN
θ value	0.125558 (rank : 63)	NC score	0.040619 (rank : 242)
Query Neighborhood Hits	206	Target Neighborhood Hits	1375	Shared Neighborhood Hits	50
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SH3G2_MOUSE
θ value	0.125558 (rank : 64)	NC score	0.308993 (rank : 19)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	127
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

STAM2_MOUSE
θ value	0.125558 (rank : 65)	NC score	0.267503 (rank : 44)
Query Neighborhood Hits	206	Target Neighborhood Hits	285	Shared Neighborhood Hits	127
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

ANM2_MOUSE
θ value	0.163984 (rank : 66)	NC score	0.177284 (rank : 98)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BTK_HUMAN
θ value	0.163984 (rank : 67)	NC score	0.084356 (rank : 157)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	125
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CRK_HUMAN
θ value	0.163984 (rank : 68)	NC score	0.255719 (rank : 50)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	123
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.163984 (rank : 69)	NC score	0.256315 (rank : 49)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	124
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

M3KL4_HUMAN
θ value	0.163984 (rank : 70)	NC score	0.082854 (rank : 161)
Query Neighborhood Hits	206	Target Neighborhood Hits	1087	Shared Neighborhood Hits	127
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

DNMBP_MOUSE
θ value	0.21417 (rank : 71)	NC score	0.235295 (rank : 70)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	132
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LIMD1_MOUSE
θ value	0.21417 (rank : 72)	NC score	0.030152 (rank : 255)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

OSTF1_HUMAN
θ value	0.21417 (rank : 73)	NC score	0.221248 (rank : 81)
Query Neighborhood Hits	206	Target Neighborhood Hits	466	Shared Neighborhood Hits	126
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PACN3_MOUSE
θ value	0.21417 (rank : 74)	NC score	0.249774 (rank : 54)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	119
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

AHI1_HUMAN
θ value	0.279714 (rank : 75)	NC score	0.213456 (rank : 86)
Query Neighborhood Hits	206	Target Neighborhood Hits	537	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANM2_HUMAN
θ value	0.365318 (rank : 76)	NC score	0.176909 (rank : 99)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	108
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

EPHB3_HUMAN
θ value	0.365318 (rank : 77)	NC score	0.036074 (rank : 250)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	35
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

GRAP_MOUSE
θ value	0.365318 (rank : 78)	NC score	0.270223 (rank : 43)
Query Neighborhood Hits	206	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

IASPP_MOUSE
θ value	0.365318 (rank : 79)	NC score	0.163380 (rank : 105)
Query Neighborhood Hits	206	Target Neighborhood Hits	1024	Shared Neighborhood Hits	131
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SH3G1_HUMAN
θ value	0.365318 (rank : 80)	NC score	0.308296 (rank : 21)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	121
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

MYLK_MOUSE
θ value	0.47712 (rank : 81)	NC score	0.023075 (rank : 267)
Query Neighborhood Hits	206	Target Neighborhood Hits	1489	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

OSTF1_MOUSE
θ value	0.47712 (rank : 82)	NC score	0.213367 (rank : 87)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	125
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SPTA2_HUMAN
θ value	0.47712 (rank : 83)	NC score	0.137061 (rank : 122)
Query Neighborhood Hits	206	Target Neighborhood Hits	888	Shared Neighborhood Hits	126
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DDEF2_MOUSE
θ value	0.62314 (rank : 84)	NC score	0.135600 (rank : 124)
Query Neighborhood Hits	206	Target Neighborhood Hits	625	Shared Neighborhood Hits	113
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NOTC3_MOUSE
θ value	0.62314 (rank : 85)	NC score	0.007407 (rank : 299)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NPHP1_MOUSE
θ value	0.62314 (rank : 86)	NC score	0.251981 (rank : 52)
Query Neighborhood Hits	206	Target Neighborhood Hits	267	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ROBO1_HUMAN
θ value	0.62314 (rank : 87)	NC score	0.019434 (rank : 274)
Query Neighborhood Hits	206	Target Neighborhood Hits	529	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

SPTA1_MOUSE
θ value	0.62314 (rank : 88)	NC score	0.129196 (rank : 130)
Query Neighborhood Hits	206	Target Neighborhood Hits	675	Shared Neighborhood Hits	117
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP1_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.168248 (rank : 101)
Query Neighborhood Hits	206	Target Neighborhood Hits	390	Shared Neighborhood Hits	107
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAM1_HUMAN
θ value	0.62314 (rank : 90)	NC score	0.263416 (rank : 46)
Query Neighborhood Hits	206	Target Neighborhood Hits	271	Shared Neighborhood Hits	126
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.62314 (rank : 91)	NC score	0.262623 (rank : 47)
Query Neighborhood Hits	206	Target Neighborhood Hits	273	Shared Neighborhood Hits	126
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	0.62314 (rank : 92)	NC score	0.248651 (rank : 56)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	123
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CASL_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.232590 (rank : 71)
Query Neighborhood Hits	206	Target Neighborhood Hits	259	Shared Neighborhood Hits	111
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.813845 (rank : 94)	NC score	0.231969 (rank : 72)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	103
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
θ value	0.813845 (rank : 95)	NC score	0.244955 (rank : 59)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DDEF2_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.130991 (rank : 128)
Query Neighborhood Hits	206	Target Neighborhood Hits	599	Shared Neighborhood Hits	116
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FRK_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.073210 (rank : 179)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	123
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PSL1_HUMAN
θ value	0.813845 (rank : 98)	NC score	0.042622 (rank : 241)
Query Neighborhood Hits	206	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RFIP1_MOUSE
θ value	0.813845 (rank : 99)	NC score	0.062909 (rank : 202)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RGS3_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.048351 (rank : 237)
Query Neighborhood Hits	206	Target Neighborhood Hits	1621	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SH3G1_MOUSE
θ value	0.813845 (rank : 101)	NC score	0.299783 (rank : 26)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	123
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

TRIPC_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.021730 (rank : 269)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	12
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

ARHG9_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.163956 (rank : 103)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	113
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

BLK_MOUSE
θ value	1.06291 (rank : 104)	NC score	0.067937 (rank : 188)
Query Neighborhood Hits	206	Target Neighborhood Hits	992	Shared Neighborhood Hits	91
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CD2AP_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.285668 (rank : 35)
Query Neighborhood Hits	206	Target Neighborhood Hits	336	Shared Neighborhood Hits	133
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

FYN_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.089673 (rank : 151)
Query Neighborhood Hits	206	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	1.06291 (rank : 107)	NC score	0.090990 (rank : 150)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	125
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

HCK_HUMAN
θ value	1.06291 (rank : 108)	NC score	0.075490 (rank : 175)
Query Neighborhood Hits	206	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MPP5_HUMAN
θ value	1.06291 (rank : 109)	NC score	0.059231 (rank : 211)
Query Neighborhood Hits	206	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	1.06291 (rank : 110)	NC score	0.058778 (rank : 213)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

RIMB1_MOUSE
θ value	1.06291 (rank : 111)	NC score	0.083863 (rank : 160)
Query Neighborhood Hits	206	Target Neighborhood Hits	1376	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RM49_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.063188 (rank : 199)
Query Neighborhood Hits	206	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q13405	Gene names	MRPL49, C11orf4, NOF1
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49) (Protein NOF1) (Neighbor of FAU) (NOF).

YES_HUMAN
θ value	1.06291 (rank : 113)	NC score	0.086705 (rank : 155)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	124
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG9_MOUSE
θ value	1.38821 (rank : 114)	NC score	0.163256 (rank : 106)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	113
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CCD27_MOUSE
θ value	1.38821 (rank : 115)	NC score	0.025569 (rank : 263)
Query Neighborhood Hits	206	Target Neighborhood Hits	461	Shared Neighborhood Hits	11
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

MAST4_HUMAN
θ value	1.38821 (rank : 116)	NC score	0.014815 (rank : 287)
Query Neighborhood Hits	206	Target Neighborhood Hits	1804	Shared Neighborhood Hits	63
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NSD1_MOUSE
θ value	1.38821 (rank : 117)	NC score	0.045263 (rank : 239)
Query Neighborhood Hits	206	Target Neighborhood Hits	472	Shared Neighborhood Hits	19
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PACN1_HUMAN
θ value	1.38821 (rank : 118)	NC score	0.240515 (rank : 63)
Query Neighborhood Hits	206	Target Neighborhood Hits	320	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	1.38821 (rank : 119)	NC score	0.242145 (rank : 61)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	120
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

S3TC1_HUMAN
θ value	1.38821 (rank : 120)	NC score	0.045081 (rank : 240)
Query Neighborhood Hits	206	Target Neighborhood Hits	78	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

TCGAP_HUMAN
θ value	1.38821 (rank : 121)	NC score	0.114797 (rank : 136)
Query Neighborhood Hits	206	Target Neighborhood Hits	872	Shared Neighborhood Hits	103
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

YES_MOUSE
θ value	1.38821 (rank : 122)	NC score	0.087075 (rank : 154)
Query Neighborhood Hits	206	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DYH5_MOUSE
θ value	1.81305 (rank : 123)	NC score	0.015140 (rank : 285)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

HCK_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.074449 (rank : 177)
Query Neighborhood Hits	206	Target Neighborhood Hits	1029	Shared Neighborhood Hits	123
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

NDUAC_HUMAN
θ value	1.81305 (rank : 125)	NC score	0.036154 (rank : 249)
Query Neighborhood Hits	206	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UI09, Q9BRV6	Gene names	NDUFA12, DAP13
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase subunit B17.2) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (13 kDa differentiation- associated protein).

PACN2_MOUSE
θ value	1.81305 (rank : 126)	NC score	0.239904 (rank : 64)
Query Neighborhood Hits	206	Target Neighborhood Hits	382	Shared Neighborhood Hits	121
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ROBO1_MOUSE
θ value	1.81305 (rank : 127)	NC score	0.017848 (rank : 280)
Query Neighborhood Hits	206	Target Neighborhood Hits	559	Shared Neighborhood Hits	13
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

TCGAP_MOUSE
θ value	1.81305 (rank : 128)	NC score	0.122737 (rank : 133)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	94
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FGR_HUMAN
θ value	2.36792 (rank : 129)	NC score	0.088723 (rank : 152)
Query Neighborhood Hits	206	Target Neighborhood Hits	1067	Shared Neighborhood Hits	123
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	2.36792 (rank : 130)	NC score	0.087234 (rank : 153)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	123
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.159120 (rank : 108)
Query Neighborhood Hits	206	Target Neighborhood Hits	432	Shared Neighborhood Hits	111
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ARAF_HUMAN
θ value	3.0926 (rank : 132)	NC score	0.027302 (rank : 258)
Query Neighborhood Hits	206	Target Neighborhood Hits	924	Shared Neighborhood Hits	32
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARHG4_HUMAN
θ value	3.0926 (rank : 133)	NC score	0.152848 (rank : 113)
Query Neighborhood Hits	206	Target Neighborhood Hits	242	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARS2_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.023444 (rank : 266)
Query Neighborhood Hits	206	Target Neighborhood Hits	186	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

B4GN4_MOUSE
θ value	3.0926 (rank : 135)	NC score	0.037270 (rank : 248)
Query Neighborhood Hits	206	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

BLK_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.068702 (rank : 186)
Query Neighborhood Hits	206	Target Neighborhood Hits	994	Shared Neighborhood Hits	97
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CD2AP_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.270428 (rank : 42)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CTDP1_HUMAN
θ value	3.0926 (rank : 138)	NC score	0.040367 (rank : 243)
Query Neighborhood Hits	206	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DAAM2_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.019055 (rank : 276)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DDEF1_MOUSE
θ value	3.0926 (rank : 140)	NC score	0.131049 (rank : 127)
Query Neighborhood Hits	206	Target Neighborhood Hits	592	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GNDS_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.018327 (rank : 279)
Query Neighborhood Hits	206	Target Neighborhood Hits	201	Shared Neighborhood Hits	13
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

LNX1_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.008860 (rank : 298)
Query Neighborhood Hits	206	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

M3K11_HUMAN
θ value	3.0926 (rank : 143)	NC score	0.072963 (rank : 180)
Query Neighborhood Hits	206	Target Neighborhood Hits	1136	Shared Neighborhood Hits	134
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MUC5B_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.025901 (rank : 262)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MYO1F_MOUSE
θ value	3.0926 (rank : 145)	NC score	0.109089 (rank : 139)
Query Neighborhood Hits	206	Target Neighborhood Hits	262	Shared Neighborhood Hits	120
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PACN2_HUMAN
θ value	3.0926 (rank : 146)	NC score	0.238958 (rank : 66)
Query Neighborhood Hits	206	Target Neighborhood Hits	339	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	3.0926 (rank : 147)	NC score	0.239366 (rank : 65)
Query Neighborhood Hits	206	Target Neighborhood Hits	385	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PCLO_MOUSE
θ value	3.0926 (rank : 148)	NC score	0.034312 (rank : 252)
Query Neighborhood Hits	206	Target Neighborhood Hits	2275	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ROBO4_MOUSE
θ value	3.0926 (rank : 149)	NC score	0.019395 (rank : 275)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

TIAM1_HUMAN
θ value	3.0926 (rank : 150)	NC score	0.057777 (rank : 218)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ASPP1_MOUSE
θ value	4.03905 (rank : 151)	NC score	0.134436 (rank : 125)
Query Neighborhood Hits	206	Target Neighborhood Hits	1244	Shared Neighborhood Hits	134
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

EFHB_MOUSE
θ value	4.03905 (rank : 152)	NC score	0.018933 (rank : 277)
Query Neighborhood Hits	206	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

NPHP1_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.218125 (rank : 83)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	107
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NRX2A_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.020011 (rank : 272)
Query Neighborhood Hits	206	Target Neighborhood Hits	614	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.029737 (rank : 256)
Query Neighborhood Hits	206	Target Neighborhood Hits	481	Shared Neighborhood Hits	18
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

S28A1_HUMAN
θ value	4.03905 (rank : 156)	NC score	0.017318 (rank : 281)
Query Neighborhood Hits	206	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O00337, O00335, O00336, Q9UEZ9	Gene names	SLC28A1, CNT1
Domain Architecture
Description	Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1).

SRBS1_HUMAN
θ value	4.03905 (rank : 157)	NC score	0.267235 (rank : 45)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	130
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRTD1_MOUSE
θ value	4.03905 (rank : 158)	NC score	0.038510 (rank : 246)
Query Neighborhood Hits	206	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

ADNP_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.013493 (rank : 292)
Query Neighborhood Hits	206	Target Neighborhood Hits	265	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2P0, O94881, Q9UG34	Gene names	ADNP, KIAA0784
Domain Architecture
Description	Activity-dependent neuroprotector (Activity-dependent neuroprotective protein).

ASPP1_HUMAN
θ value	5.27518 (rank : 160)	NC score	0.133071 (rank : 126)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	127
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CDSN_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.037651 (rank : 247)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

CEP35_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.020062 (rank : 271)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

F120A_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.015488 (rank : 284)
Query Neighborhood Hits	206	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZB2, O60649, Q14688, Q4VXF4, Q4VXF5, Q4VXG2, Q96I21, Q9NZB1	Gene names	FAM120A, C9orf10, KIAA0183
Domain Architecture	No domain graphic available
Description	UPF0318 protein FAM120A.

GON4L_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.033545 (rank : 253)
Query Neighborhood Hits	206	Target Neighborhood Hits	555	Shared Neighborhood Hits	20
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HIRP3_HUMAN
θ value	5.27518 (rank : 165)	NC score	0.022147 (rank : 268)
Query Neighborhood Hits	206	Target Neighborhood Hits	323	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

MDC1_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.039161 (rank : 245)
Query Neighborhood Hits	206	Target Neighborhood Hits	1446	Shared Neighborhood Hits	56
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MLL4_HUMAN
θ value	5.27518 (rank : 167)	NC score	0.029365 (rank : 257)
Query Neighborhood Hits	206	Target Neighborhood Hits	722	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MYO1F_HUMAN
θ value	5.27518 (rank : 168)	NC score	0.110444 (rank : 137)
Query Neighborhood Hits	206	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

NCK2_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.228925 (rank : 74)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	125
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCOR2_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.026752 (rank : 261)
Query Neighborhood Hits	206	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

SAPS3_MOUSE
θ value	5.27518 (rank : 171)	NC score	0.012120 (rank : 293)
Query Neighborhood Hits	206	Target Neighborhood Hits	77	Shared Neighborhood Hits	6
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

SRBS1_MOUSE
θ value	5.27518 (rank : 172)	NC score	0.273473 (rank : 39)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	134
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRCA_HUMAN
θ value	5.27518 (rank : 173)	NC score	0.013677 (rank : 291)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

WASP_HUMAN
θ value	5.27518 (rank : 174)	NC score	0.027283 (rank : 259)
Query Neighborhood Hits	206	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

ABL1_HUMAN
θ value	6.88961 (rank : 175)	NC score	0.058311 (rank : 215)
Query Neighborhood Hits	206	Target Neighborhood Hits	1220	Shared Neighborhood Hits	94
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.058730 (rank : 214)
Query Neighborhood Hits	206	Target Neighborhood Hits	1178	Shared Neighborhood Hits	92
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

DSC1_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.001054 (rank : 304)
Query Neighborhood Hits	206	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	Q08554	Gene names	DSC1
Domain Architecture
Description	Desmocollin-1 precursor (Desmosomal glycoprotein 2/3) (DG2/DG3).

GIDRP_MOUSE
θ value	6.88961 (rank : 178)	NC score	0.013737 (rank : 290)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

GLI2_HUMAN
θ value	6.88961 (rank : 179)	NC score	-0.001394 (rank : 305)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	11
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

GLI3_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.003106 (rank : 302)
Query Neighborhood Hits	206	Target Neighborhood Hits	871	Shared Neighborhood Hits	11
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

JIP2_HUMAN
θ value	6.88961 (rank : 181)	NC score	0.053611 (rank : 229)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	44
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LCK_HUMAN
θ value	6.88961 (rank : 182)	NC score	0.060700 (rank : 205)
Query Neighborhood Hits	206	Target Neighborhood Hits	987	Shared Neighborhood Hits	83
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LYN_MOUSE
θ value	6.88961 (rank : 183)	NC score	0.068840 (rank : 185)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	109
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MINT_HUMAN
θ value	6.88961 (rank : 184)	NC score	0.019750 (rank : 273)
Query Neighborhood Hits	206	Target Neighborhood Hits	1291	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MYOD1_MOUSE
θ value	6.88961 (rank : 185)	NC score	0.009993 (rank : 295)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

RIMB2_MOUSE
θ value	6.88961 (rank : 186)	NC score	0.130539 (rank : 129)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	81
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

TEC_HUMAN
θ value	6.88961 (rank : 187)	NC score	0.063200 (rank : 198)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TGON1_MOUSE
θ value	6.88961 (rank : 188)	NC score	0.020476 (rank : 270)
Query Neighborhood Hits	206	Target Neighborhood Hits	243	Shared Neighborhood Hits	12
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

WHRN_HUMAN
θ value	6.88961 (rank : 189)	NC score	0.010928 (rank : 294)
Query Neighborhood Hits	206	Target Neighborhood Hits	325	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

ABL2_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.055847 (rank : 223)
Query Neighborhood Hits	206	Target Neighborhood Hits	1045	Shared Neighborhood Hits	81
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ATS13_HUMAN
θ value	8.99809 (rank : 191)	NC score	0.002295 (rank : 303)
Query Neighborhood Hits	206	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

CSKI1_HUMAN
θ value	8.99809 (rank : 192)	NC score	0.024496 (rank : 264)
Query Neighborhood Hits	206	Target Neighborhood Hits	997	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EAN57_HUMAN
θ value	8.99809 (rank : 193)	NC score	0.014573 (rank : 288)
Query Neighborhood Hits	206	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	O43247, Q6ICF2, Q9Y4V8	Gene names	EAN57
Domain Architecture	No domain graphic available
Description	Protein EAN57.

KI21A_MOUSE
θ value	8.99809 (rank : 194)	NC score	0.004392 (rank : 301)
Query Neighborhood Hits	206	Target Neighborhood Hits	1317	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

LCK_MOUSE
θ value	8.99809 (rank : 195)	NC score	0.059751 (rank : 207)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	82
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MATR3_MOUSE
θ value	8.99809 (rank : 196)	NC score	0.009257 (rank : 297)
Query Neighborhood Hits	206	Target Neighborhood Hits	321	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

MBD5_HUMAN
θ value	8.99809 (rank : 197)	NC score	0.017085 (rank : 282)
Query Neighborhood Hits	206	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MBP_MOUSE
θ value	8.99809 (rank : 198)	NC score	0.013851 (rank : 289)
Query Neighborhood Hits	206	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P04370, Q01585, Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1	Gene names	Mbp, Shi
Domain Architecture
Description	Myelin basic protein (MBP) (Myelin A1 protein).

MICA3_HUMAN
θ value	8.99809 (rank : 199)	NC score	0.009679 (rank : 296)
Query Neighborhood Hits	206	Target Neighborhood Hits	160	Shared Neighborhood Hits	7
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

NCF1_HUMAN
θ value	8.99809 (rank : 200)	NC score	0.218346 (rank : 82)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	110
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCOR2_MOUSE
θ value	8.99809 (rank : 201)	NC score	0.026875 (rank : 260)
Query Neighborhood Hits	206	Target Neighborhood Hits	790	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

RM49_MOUSE
θ value	8.99809 (rank : 202)	NC score	0.030653 (rank : 254)
Query Neighborhood Hits	206	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ40, Q3UC21, Q8C5R0, Q8C7P3	Gene names	Mrpl49
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49).

SF3B1_HUMAN
θ value	8.99809 (rank : 203)	NC score	0.016818 (rank : 283)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	13
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	8.99809 (rank : 204)	NC score	0.018749 (rank : 278)
Query Neighborhood Hits	206	Target Neighborhood Hits	352	Shared Neighborhood Hits	14
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SI1L3_HUMAN
θ value	8.99809 (rank : 205)	NC score	0.006826 (rank : 300)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	11
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

TDRKH_MOUSE
θ value	8.99809 (rank : 206)	NC score	0.014829 (rank : 286)
Query Neighborhood Hits	206	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

ABI3_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.226038 (rank : 78)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.227644 (rank : 77)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AMPH_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.083907 (rank : 159)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.063102 (rank : 201)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ARHG3_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.054801 (rank : 226)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.054297 (rank : 228)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.109748 (rank : 138)
Query Neighborhood Hits	206	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.078656 (rank : 172)
Query Neighborhood Hits	206	Target Neighborhood Hits	172	Shared Neighborhood Hits	55
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.172826 (rank : 100)
Query Neighborhood Hits	206	Target Neighborhood Hits	376	Shared Neighborhood Hits	121
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.177503 (rank : 97)
Query Neighborhood Hits	206	Target Neighborhood Hits	394	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.192930 (rank : 91)
Query Neighborhood Hits	206	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.203003 (rank : 89)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	125
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.053570 (rank : 230)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.053052 (rank : 232)
Query Neighborhood Hits	206	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.059716 (rank : 208)
Query Neighborhood Hits	206	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.068538 (rank : 187)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.094705 (rank : 146)
Query Neighborhood Hits	206	Target Neighborhood Hits	1156	Shared Neighborhood Hits	113
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCR_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.051108 (rank : 235)
Query Neighborhood Hits	206	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BIN1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.060296 (rank : 206)
Query Neighborhood Hits	206	Target Neighborhood Hits	335	Shared Neighborhood Hits	58
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.057527 (rank : 221)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CIP4_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.085671 (rank : 156)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	59
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSK_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.057553 (rank : 220)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.057562 (rank : 219)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DOCK1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.064672 (rank : 193)
Query Neighborhood Hits	206	Target Neighborhood Hits	191	Shared Neighborhood Hits	75
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

EPS8_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.076295 (rank : 173)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	78
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.082800 (rank : 163)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	89
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.080430 (rank : 171)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.082115 (rank : 164)
Query Neighborhood Hits	206	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.101355 (rank : 143)
Query Neighborhood Hits	206	Target Neighborhood Hits	193	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.100204 (rank : 144)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.103978 (rank : 141)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.119402 (rank : 135)
Query Neighborhood Hits	206	Target Neighborhood Hits	168	Shared Neighborhood Hits	96
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ITK_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.058253 (rank : 216)
Query Neighborhood Hits	206	Target Neighborhood Hits	1016	Shared Neighborhood Hits	100
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.054493 (rank : 227)
Query Neighborhood Hits	206	Target Neighborhood Hits	985	Shared Neighborhood Hits	90
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LYN_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.067297 (rank : 189)
Query Neighborhood Hits	206	Target Neighborhood Hits	1022	Shared Neighborhood Hits	111
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.063145 (rank : 200)
Query Neighborhood Hits	206	Target Neighborhood Hits	1071	Shared Neighborhood Hits	118
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.065886 (rank : 190)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	127
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MYO1E_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.096026 (rank : 145)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NCF1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.217356 (rank : 84)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCK1_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.245687 (rank : 58)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	127
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NGEF_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.073815 (rank : 178)
Query Neighborhood Hits	206	Target Neighborhood Hits	166	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.072040 (rank : 182)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.107455 (rank : 140)
Query Neighborhood Hits	206	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.146025 (rank : 115)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NRAP_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.050342 (rank : 236)
Query Neighborhood Hits	206	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

P85A_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.076228 (rank : 174)
Query Neighborhood Hits	206	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.080617 (rank : 170)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	83
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.059399 (rank : 209)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	59
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.055643 (rank : 224)
Query Neighborhood Hits	206	Target Neighborhood Hits	519	Shared Neighborhood Hits	56
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PEX13_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.162204 (rank : 107)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	84
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.158175 (rank : 109)
Query Neighborhood Hits	206	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.128365 (rank : 132)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.140529 (rank : 119)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	112
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.139977 (rank : 120)
Query Neighborhood Hits	206	Target Neighborhood Hits	280	Shared Neighborhood Hits	111
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.065377 (rank : 191)
Query Neighborhood Hits	206	Target Neighborhood Hits	254	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.061156 (rank : 204)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PTK6_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.057994 (rank : 217)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	110
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.059079 (rank : 212)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	109
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RASA1_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.071609 (rank : 183)
Query Neighborhood Hits	206	Target Neighborhood Hits	258	Shared Neighborhood Hits	47
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG26_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.119964 (rank : 134)
Query Neighborhood Hits	206	Target Neighborhood Hits	281	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.080854 (rank : 169)
Query Neighborhood Hits	206	Target Neighborhood Hits	1479	Shared Neighborhood Hits	114
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.128900 (rank : 131)
Query Neighborhood Hits	206	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SH21B_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.061431 (rank : 203)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.063425 (rank : 195)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.247094 (rank : 57)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	125
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.248735 (rank : 55)
Query Neighborhood Hits	206	Target Neighborhood Hits	332	Shared Neighborhood Hits	126
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN1_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.059308 (rank : 210)
Query Neighborhood Hits	206	Target Neighborhood Hits	1041	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.069582 (rank : 184)
Query Neighborhood Hits	206	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.082830 (rank : 162)
Query Neighborhood Hits	206	Target Neighborhood Hits	113	Shared Neighborhood Hits	33
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.081715 (rank : 165)
Query Neighborhood Hits	206	Target Neighborhood Hits	117	Shared Neighborhood Hits	32
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.094154 (rank : 147)
Query Neighborhood Hits	206	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.092365 (rank : 148)
Query Neighborhood Hits	206	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.055428 (rank : 225)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.154491 (rank : 111)
Query Neighborhood Hits	206	Target Neighborhood Hits	207	Shared Neighborhood Hits	93
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.157263 (rank : 110)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	93
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.081174 (rank : 167)
Query Neighborhood Hits	206	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.072066 (rank : 181)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.103668 (rank : 142)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.092026 (rank : 149)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.084231 (rank : 158)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	126
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.074918 (rank : 176)
Query Neighborhood Hits	206	Target Neighborhood Hits	1033	Shared Neighborhood Hits	113
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRMS_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.051771 (rank : 234)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	77
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC3_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.181673 (rank : 95)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.181832 (rank : 94)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.203293 (rank : 88)
Query Neighborhood Hits	206	Target Neighborhood Hits	276	Shared Neighborhood Hits	122
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.197582 (rank : 90)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	121
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STS1_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.064783 (rank : 192)
Query Neighborhood Hits	206	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.063974 (rank : 194)
Query Neighborhood Hits	206	Target Neighborhood Hits	104	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.081001 (rank : 168)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TEC_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.063242 (rank : 197)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	102
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TIAM1_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.052356 (rank : 233)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TXK_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.056510 (rank : 222)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	92
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.063411 (rank : 196)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	103
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV2_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.152792 (rank : 114)
Query Neighborhood Hits	206	Target Neighborhood Hits	453	Shared Neighborhood Hits	121
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.153787 (rank : 112)
Query Neighborhood Hits	206	Target Neighborhood Hits	456	Shared Neighborhood Hits	120
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.139637 (rank : 121)
Query Neighborhood Hits	206	Target Neighborhood Hits	398	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.136711 (rank : 123)
Query Neighborhood Hits	206	Target Neighborhood Hits	404	Shared Neighborhood Hits	124
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.164083 (rank : 102)
Query Neighborhood Hits	206	Target Neighborhood Hits	452	Shared Neighborhood Hits	127
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.163604 (rank : 104)
Query Neighborhood Hits	206	Target Neighborhood Hits	430	Shared Neighborhood Hits	129
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

RUSC1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC1_HUMAN
NC score	0.957171 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC2_HUMAN
NC score	0.681593 (rank : 3)	θ value	9.83387e-39 (rank : 3)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	69
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
NC score	0.657656 (rank : 4)	θ value	2.86122e-38 (rank : 4)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

NCF2_HUMAN
NC score	0.364182 (rank : 5)	θ value	0.0252991 (rank : 37)
Query Neighborhood Hits	206	Target Neighborhood Hits	229	Shared Neighborhood Hits	118
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI2_MOUSE
NC score	0.345057 (rank : 6)	θ value	3.19293e-05 (rank : 8)
Query Neighborhood Hits	206	Target Neighborhood Hits	266	Shared Neighborhood Hits	121
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.340951 (rank : 7)	θ value	3.19293e-05 (rank : 7)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

EFS_MOUSE
NC score	0.340317 (rank : 8)	θ value	0.000270298 (rank : 12)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	116
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EFS_HUMAN
NC score	0.337763 (rank : 9)	θ value	0.00020696 (rank : 11)
Query Neighborhood Hits	206	Target Neighborhood Hits	348	Shared Neighborhood Hits	123
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

HCLS1_HUMAN
NC score	0.333527 (rank : 10)	θ value	0.0252991 (rank : 36)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	126
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

PPIP1_HUMAN
NC score	0.332794 (rank : 11)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	206	Target Neighborhood Hits	389	Shared Neighborhood Hits	130
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

HCLS1_MOUSE
NC score	0.324641 (rank : 12)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	206	Target Neighborhood Hits	329	Shared Neighborhood Hits	125
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

VINEX_MOUSE
NC score	0.322804 (rank : 13)	θ value	0.0113563 (rank : 28)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	127
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRC8_HUMAN
NC score	0.318895 (rank : 14)	θ value	0.0148317 (rank : 31)
Query Neighborhood Hits	206	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.317201 (rank : 15)	θ value	0.0148317 (rank : 32)
Query Neighborhood Hits	206	Target Neighborhood Hits	292	Shared Neighborhood Hits	128
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

NCF4_MOUSE
NC score	0.313569 (rank : 16)	θ value	0.0330416 (rank : 43)
Query Neighborhood Hits	206	Target Neighborhood Hits	177	Shared Neighborhood Hits	107
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VINEX_HUMAN
NC score	0.312243 (rank : 17)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	206	Target Neighborhood Hits	270	Shared Neighborhood Hits	127
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PPIP1_MOUSE
NC score	0.311212 (rank : 18)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	206	Target Neighborhood Hits	377	Shared Neighborhood Hits	127
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G2_MOUSE
NC score	0.308993 (rank : 19)	θ value	0.125558 (rank : 64)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	127
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ABI1_MOUSE
NC score	0.308991 (rank : 20)	θ value	0.0736092 (rank : 53)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G1_HUMAN
NC score	0.308296 (rank : 21)	θ value	0.365318 (rank : 80)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	121
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_MOUSE
NC score	0.307112 (rank : 22)	θ value	0.0252991 (rank : 38)
Query Neighborhood Hits	206	Target Neighborhood Hits	236	Shared Neighborhood Hits	124
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCF4_HUMAN
NC score	0.306330 (rank : 23)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	206	Target Neighborhood Hits	161	Shared Neighborhood Hits	99
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3G2_HUMAN
NC score	0.303624 (rank : 24)	θ value	0.0736092 (rank : 57)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	126
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.302888 (rank : 25)	θ value	0.0961366 (rank : 58)
Query Neighborhood Hits	206	Target Neighborhood Hits	222	Shared Neighborhood Hits	122
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_MOUSE
NC score	0.299783 (rank : 26)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	123
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI1_HUMAN
NC score	0.298732 (rank : 27)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	206	Target Neighborhood Hits	257	Shared Neighborhood Hits	117
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

DBNL_HUMAN
NC score	0.294138 (rank : 28)	θ value	0.0148317 (rank : 29)
Query Neighborhood Hits	206	Target Neighborhood Hits	244	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

LASP1_HUMAN
NC score	0.293459 (rank : 29)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	107
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

GRAP2_MOUSE
NC score	0.291117 (rank : 30)	θ value	0.0330416 (rank : 42)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	130
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB2_HUMAN
NC score	0.286787 (rank : 31)	θ value	0.0193708 (rank : 33)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	129
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

LASP1_MOUSE
NC score	0.286603 (rank : 32)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	206	Target Neighborhood Hits	297	Shared Neighborhood Hits	106
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DBNL_MOUSE
NC score	0.286531 (rank : 33)	θ value	0.0148317 (rank : 30)
Query Neighborhood Hits	206	Target Neighborhood Hits	306	Shared Neighborhood Hits	109
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

GRB2_MOUSE
NC score	0.286363 (rank : 34)	θ value	0.0193708 (rank : 34)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

CD2AP_MOUSE
NC score	0.285668 (rank : 35)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	206	Target Neighborhood Hits	336	Shared Neighborhood Hits	133
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GRAP2_HUMAN
NC score	0.285179 (rank : 36)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	206	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_HUMAN
NC score	0.282775 (rank : 37)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CRKL_HUMAN
NC score	0.279453 (rank : 38)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	206	Target Neighborhood Hits	313	Shared Neighborhood Hits	123
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SRBS1_MOUSE
NC score	0.273473 (rank : 39)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	134
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CRKL_MOUSE
NC score	0.272789 (rank : 40)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	124
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

BCAR1_MOUSE
NC score	0.271994 (rank : 41)	θ value	0.0431538 (rank : 45)
Query Neighborhood Hits	206	Target Neighborhood Hits	438	Shared Neighborhood Hits	128
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CD2AP_HUMAN
NC score	0.270428 (rank : 42)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	206	Target Neighborhood Hits	315	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP_MOUSE
NC score	0.270223 (rank : 43)	θ value	0.365318 (rank : 78)
Query Neighborhood Hits	206	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAM2_MOUSE
NC score	0.267503 (rank : 44)	θ value	0.125558 (rank : 65)
Query Neighborhood Hits	206	Target Neighborhood Hits	285	Shared Neighborhood Hits	127
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRBS1_HUMAN
NC score	0.267235 (rank : 45)	θ value	4.03905 (rank : 157)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	130
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_HUMAN
NC score	0.263416 (rank : 46)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	206	Target Neighborhood Hits	271	Shared Neighborhood Hits	126
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.262623 (rank : 47)	θ value	0.62314 (rank : 91)
Query Neighborhood Hits	206	Target Neighborhood Hits	273	Shared Neighborhood Hits	126
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

BCAR1_HUMAN
NC score	0.261603 (rank : 48)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	206	Target Neighborhood Hits	554	Shared Neighborhood Hits	130
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRK_MOUSE
NC score	0.256315 (rank : 49)	θ value	0.163984 (rank : 69)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	124
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.255719 (rank : 50)	θ value	0.163984 (rank : 68)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	123
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DNMBP_HUMAN
NC score	0.254447 (rank : 51)	θ value	0.0563607 (rank : 49)
Query Neighborhood Hits	206	Target Neighborhood Hits	413	Shared Neighborhood Hits	132
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NPHP1_MOUSE
NC score	0.251981 (rank : 52)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	206	Target Neighborhood Hits	267	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NEBL_HUMAN
NC score	0.251569 (rank : 53)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	206	Target Neighborhood Hits	457	Shared Neighborhood Hits	113
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PACN3_MOUSE
NC score	0.249774 (rank : 54)	θ value	0.21417 (rank : 74)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	119
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SH3K1_MOUSE
NC score	0.248735 (rank : 55)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	206	Target Neighborhood Hits	332	Shared Neighborhood Hits	126
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAM2_HUMAN
NC score	0.248651 (rank : 56)	θ value	0.62314 (rank : 92)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	123
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH3K1_HUMAN
NC score	0.247094 (rank : 57)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	125
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCK1_HUMAN
NC score	0.245687 (rank : 58)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	206	Target Neighborhood Hits	312	Shared Neighborhood Hits	127
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CT032_HUMAN
NC score	0.244955 (rank : 59)	θ value	0.813845 (rank : 95)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

SHLB2_MOUSE
NC score	0.244464 (rank : 60)	θ value	0.00869519 (rank : 25)
Query Neighborhood Hits	206	Target Neighborhood Hits	88	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

PACN1_MOUSE
NC score	0.242145 (rank : 61)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	120
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SHLB2_HUMAN
NC score	0.241986 (rank : 62)	θ value	0.00665767 (rank : 23)
Query Neighborhood Hits	206	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

PACN1_HUMAN
NC score	0.240515 (rank : 63)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	206	Target Neighborhood Hits	320	Shared Neighborhood Hits	120
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.239904 (rank : 64)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	206	Target Neighborhood Hits	382	Shared Neighborhood Hits	121
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
NC score	0.239366 (rank : 65)	θ value	3.0926 (rank : 147)
Query Neighborhood Hits	206	Target Neighborhood Hits	385	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN2_HUMAN
NC score	0.238958 (rank : 66)	θ value	3.0926 (rank : 146)
Query Neighborhood Hits	206	Target Neighborhood Hits	339	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

NEBU_HUMAN
NC score	0.237152 (rank : 67)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	206	Target Neighborhood Hits	420	Shared Neighborhood Hits	114
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SHLB1_MOUSE
NC score	0.237052 (rank : 68)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB1_HUMAN
NC score	0.237023 (rank : 69)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

DNMBP_MOUSE
NC score	0.235295 (rank : 70)	θ value	0.21417 (rank : 71)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	132
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CASL_HUMAN
NC score	0.232590 (rank : 71)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	206	Target Neighborhood Hits	259	Shared Neighborhood Hits	111
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.231969 (rank : 72)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	103
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ITSN2_HUMAN
NC score	0.229355 (rank : 73)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	206	Target Neighborhood Hits	1173	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NCK2_HUMAN
NC score	0.228925 (rank : 74)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	206	Target Neighborhood Hits	310	Shared Neighborhood Hits	125
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RHG04_HUMAN
NC score	0.228842 (rank : 75)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	206	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

AHI1_MOUSE
NC score	0.227827 (rank : 76)	θ value	0.0330416 (rank : 40)
Query Neighborhood Hits	206	Target Neighborhood Hits	496	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ABI3_MOUSE
NC score	0.227644 (rank : 77)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_HUMAN
NC score	0.226038 (rank : 78)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	206	Target Neighborhood Hits	227	Shared Neighborhood Hits	104
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN1_MOUSE
NC score	0.226006 (rank : 79)	θ value	1.43324e-05 (rank : 5)
Query Neighborhood Hits	206	Target Neighborhood Hits	1669	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.224690 (rank : 80)	θ value	1.87187e-05 (rank : 6)
Query Neighborhood Hits	206	Target Neighborhood Hits	1757	Shared Neighborhood Hits	149
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

OSTF1_HUMAN
NC score	0.221248 (rank : 81)	θ value	0.21417 (rank : 73)
Query Neighborhood Hits	206	Target Neighborhood Hits	466	Shared Neighborhood Hits	126
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NCF1_HUMAN
NC score	0.218346 (rank : 82)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	110
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NPHP1_HUMAN
NC score	0.218125 (rank : 83)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	107
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NCF1_MOUSE
NC score	0.217356 (rank : 84)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	116
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ITSN2_MOUSE
NC score	0.217197 (rank : 85)	θ value	0.00665767 (rank : 22)
Query Neighborhood Hits	206	Target Neighborhood Hits	1371	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

AHI1_HUMAN
NC score	0.213456 (rank : 86)	θ value	0.279714 (rank : 75)
Query Neighborhood Hits	206	Target Neighborhood Hits	537	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

OSTF1_MOUSE
NC score	0.213367 (rank : 87)	θ value	0.47712 (rank : 82)
Query Neighborhood Hits	206	Target Neighborhood Hits	467	Shared Neighborhood Hits	125
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

STAC_HUMAN
NC score	0.203293 (rank : 88)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	206	Target Neighborhood Hits	276	Shared Neighborhood Hits	122
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_MOUSE
NC score	0.203003 (rank : 89)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	206	Target Neighborhood Hits	396	Shared Neighborhood Hits	125
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

STAC_MOUSE
NC score	0.197582 (rank : 90)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	206	Target Neighborhood Hits	268	Shared Neighborhood Hits	121
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_HUMAN
NC score	0.192930 (rank : 91)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	206	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

IASPP_HUMAN
NC score	0.185081 (rank : 92)	θ value	0.125558 (rank : 61)
Query Neighborhood Hits	206	Target Neighborhood Hits	688	Shared Neighborhood Hits	130
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRGP2_MOUSE
NC score	0.184475 (rank : 93)	θ value	0.0431538 (rank : 48)
Query Neighborhood Hits	206	Target Neighborhood Hits	324	Shared Neighborhood Hits	107
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_MOUSE
NC score	0.181832 (rank : 94)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	206	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.181673 (rank : 95)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRGP2_HUMAN
NC score	0.181079 (rank : 96)	θ value	0.0563607 (rank : 51)
Query Neighborhood Hits	206	Target Neighborhood Hits	331	Shared Neighborhood Hits	106
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ARHG6_MOUSE
NC score	0.177503 (rank : 97)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	206	Target Neighborhood Hits	394	Shared Neighborhood Hits	119
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ANM2_MOUSE
NC score	0.177284 (rank : 98)	θ value	0.163984 (rank : 66)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_HUMAN
NC score	0.176909 (rank : 99)	θ value	0.365318 (rank : 76)
Query Neighborhood Hits	206	Target Neighborhood Hits	175	Shared Neighborhood Hits	108
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_HUMAN
NC score	0.172826 (rank : 100)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	206	Target Neighborhood Hits	376	Shared Neighborhood Hits	121
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SRGP1_HUMAN
NC score	0.168248 (rank : 101)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	206	Target Neighborhood Hits	390	Shared Neighborhood Hits	107
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

VAV_HUMAN
NC score	0.164083 (rank : 102)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	206	Target Neighborhood Hits	452	Shared Neighborhood Hits	127
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG9_HUMAN
NC score	0.163956 (rank : 103)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	206	Target Neighborhood Hits	235	Shared Neighborhood Hits	113
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

VAV_MOUSE
NC score	0.163604 (rank : 104)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	206	Target Neighborhood Hits	430	Shared Neighborhood Hits	129
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

IASPP_MOUSE
NC score	0.163380 (rank : 105)	θ value	0.365318 (rank : 79)
Query Neighborhood Hits	206	Target Neighborhood Hits	1024	Shared Neighborhood Hits	131
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ARHG9_MOUSE
NC score	0.163256 (rank : 106)	θ value	1.38821 (rank : 114)
Query Neighborhood Hits	206	Target Neighborhood Hits	234	Shared Neighborhood Hits	113
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PEX13_HUMAN
NC score	0.162204 (rank : 107)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	206	Target Neighborhood Hits	128	Shared Neighborhood Hits	84
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

FNBP2_HUMAN
NC score	0.159120 (rank : 108)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	206	Target Neighborhood Hits	432	Shared Neighborhood Hits	111
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

PEX13_MOUSE
NC score	0.158175 (rank : 109)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	206	Target Neighborhood Hits	126	Shared Neighborhood Hits	83
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SNX18_MOUSE
NC score	0.157263 (rank : 110)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	206	Target Neighborhood Hits	198	Shared Neighborhood Hits	93
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.154491 (rank : 111)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	206	Target Neighborhood Hits	207	Shared Neighborhood Hits	93
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV2_MOUSE
NC score	0.153787 (rank : 112)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	206	Target Neighborhood Hits	456	Shared Neighborhood Hits	120
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG4_HUMAN
NC score	0.152848 (rank : 113)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	206	Target Neighborhood Hits	242	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

VAV2_HUMAN
NC score	0.152792 (rank : 114)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	206	Target Neighborhood Hits	453	Shared Neighborhood Hits	121
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

NOXO1_MOUSE
NC score	0.146025 (rank : 115)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	206	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SPTA1_HUMAN
NC score	0.144615 (rank : 116)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	206	Target Neighborhood Hits	748	Shared Neighborhood Hits	121
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SETBP_HUMAN
NC score	0.142963 (rank : 117)	θ value	9.29e-05 (rank : 9)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SETBP_MOUSE
NC score	0.140771 (rank : 118)	θ value	0.000158464 (rank : 10)
Query Neighborhood Hits	206	Target Neighborhood Hits	352	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

PLCG1_MOUSE
NC score	0.140529 (rank : 119)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	206	Target Neighborhood Hits	314	Shared Neighborhood Hits	112
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.139977 (rank : 120)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	206	Target Neighborhood Hits	280	Shared Neighborhood Hits	111
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV3_HUMAN
NC score	0.139637 (rank : 121)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	206	Target Neighborhood Hits	398	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SPTA2_HUMAN
NC score	0.137061 (rank : 122)	θ value	0.47712 (rank : 83)
Query Neighborhood Hits	206	Target Neighborhood Hits	888	Shared Neighborhood Hits	126
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

VAV3_MOUSE
NC score	0.136711 (rank : 123)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	206	Target Neighborhood Hits	404	Shared Neighborhood Hits	124
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

DDEF2_MOUSE
NC score	0.135600 (rank : 124)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	206	Target Neighborhood Hits	625	Shared Neighborhood Hits	113
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ASPP1_MOUSE
NC score	0.134436 (rank : 125)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	206	Target Neighborhood Hits	1244	Shared Neighborhood Hits	134
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.133071 (rank : 126)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	206	Target Neighborhood Hits	956	Shared Neighborhood Hits	127
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DDEF1_MOUSE
NC score	0.131049 (rank : 127)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	206	Target Neighborhood Hits	592	Shared Neighborhood Hits	105
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
NC score	0.130991 (rank : 128)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	206	Target Neighborhood Hits	599	Shared Neighborhood Hits	116
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

RIMB2_MOUSE
NC score	0.130539 (rank : 129)	θ value	6.88961 (rank : 186)
Query Neighborhood Hits	206	Target Neighborhood Hits	246	Shared Neighborhood Hits	81
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA1_MOUSE
NC score	0.129196 (rank : 130)	θ value	0.62314 (rank : 88)
Query Neighborhood Hits	206	Target Neighborhood Hits	675	Shared Neighborhood Hits	117
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RIMB2_HUMAN
NC score	0.128900 (rank : 131)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	206	Target Neighborhood Hits	263	Shared Neighborhood Hits	87
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PLCG1_HUMAN
NC score	0.128365 (rank : 132)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	109
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

TCGAP_MOUSE
NC score	0.122737 (rank : 133)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	206	Target Neighborhood Hits	409	Shared Neighborhood Hits	94
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG26_HUMAN
NC score	0.119964 (rank : 134)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	206	Target Neighborhood Hits	281	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L3_MOUSE
NC score	0.119402 (rank : 135)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	206	Target Neighborhood Hits	168	Shared Neighborhood Hits	96
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

TCGAP_HUMAN
NC score	0.114797 (rank : 136)	θ value	1.38821 (rank : 121)
Query Neighborhood Hits	206	Target Neighborhood Hits	872	Shared Neighborhood Hits	103
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MYO1F_HUMAN
NC score	0.110444 (rank : 137)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	206	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

ARHG4_MOUSE
NC score	0.109748 (rank : 138)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	206	Target Neighborhood Hits	185	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MYO1F_MOUSE
NC score	0.109089 (rank : 139)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	206	Target Neighborhood Hits	262	Shared Neighborhood Hits	120
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NOXO1_HUMAN
NC score	0.107455 (rank : 140)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	206	Target Neighborhood Hits	100	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

ES8L3_HUMAN
NC score	0.103978 (rank : 141)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	206	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SPN90_HUMAN
NC score	0.103668 (rank : 142)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ES8L2_HUMAN
NC score	0.101355 (rank : 143)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	206	Target Neighborhood Hits	193	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
NC score	0.100204 (rank : 144)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	206	Target Neighborhood Hits	169	Shared Neighborhood Hits	85
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

MYO1E_HUMAN
NC score	0.096026 (rank : 145)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	206	Target Neighborhood Hits	293	Shared Neighborhood Hits	120
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ASPP2_HUMAN
NC score	0.094705 (rank : 146)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	206	Target Neighborhood Hits	1156	Shared Neighborhood Hits	113
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SLAP2_HUMAN
NC score	0.094154 (rank : 147)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	206	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
NC score	0.092365 (rank : 148)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	206	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_MOUSE
NC score	0.092026 (rank : 149)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

FYN_MOUSE
NC score	0.090990 (rank : 150)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	206	Target Neighborhood Hits	1073	Shared Neighborhood Hits	125
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FYN_HUMAN
NC score	0.089673 (rank : 151)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	206	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_HUMAN
NC score	0.088723 (rank : 152)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	206	Target Neighborhood Hits	1067	Shared Neighborhood Hits	123
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
NC score	0.087234 (rank : 153)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	206	Target Neighborhood Hits	1069	Shared Neighborhood Hits	123
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_MOUSE
NC score	0.087075 (rank : 154)	θ value	1.38821 (rank : 122)
Query Neighborhood Hits	206	Target Neighborhood Hits	1052	Shared Neighborhood Hits	125
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.086705 (rank : 155)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	206	Target Neighborhood Hits	1059	Shared Neighborhood Hits	124
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CIP4_HUMAN
NC score	0.085671 (rank : 156)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	206	Target Neighborhood Hits	374	Shared Neighborhood Hits	59
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

BTK_HUMAN
NC score	0.084356 (rank : 157)	θ value	0.163984 (rank : 67)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	125
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SRC_HUMAN
NC score	0.084231 (rank : 158)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	126
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

AMPH_HUMAN
NC score	0.083907 (rank : 159)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	206	Target Neighborhood Hits	455	Shared Neighborhood Hits	74
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RIMB1_MOUSE
NC score	0.083863 (rank : 160)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	206	Target Neighborhood Hits	1376	Shared Neighborhood Hits	123
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

M3KL4_HUMAN
NC score	0.082854 (rank : 161)	θ value	0.163984 (rank : 70)
Query Neighborhood Hits	206	Target Neighborhood Hits	1087	Shared Neighborhood Hits	127
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SLAP1_HUMAN
NC score	0.082830 (rank : 162)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	206	Target Neighborhood Hits	113	Shared Neighborhood Hits	33
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

EPS8_MOUSE
NC score	0.082800 (rank : 163)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	206	Target Neighborhood Hits	157	Shared Neighborhood Hits	89
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_MOUSE
NC score	0.082115 (rank : 164)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	206	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SLAP1_MOUSE
NC score	0.081715 (rank : 165)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	206	Target Neighborhood Hits	117	Shared Neighborhood Hits	32
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BTK_MOUSE
NC score	0.081396 (rank : 166)	θ value	0.0736092 (rank : 54)
Query Neighborhood Hits	206	Target Neighborhood Hits	1017	Shared Neighborhood Hits	117
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SNX9_HUMAN
NC score	0.081174 (rank : 167)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	206	Target Neighborhood Hits	148	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

STS2_HUMAN
NC score	0.081001 (rank : 168)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	58
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RIMB1_HUMAN
NC score	0.080854 (rank : 169)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	206	Target Neighborhood Hits	1479	Shared Neighborhood Hits	114
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

P85A_MOUSE
NC score	0.080617 (rank : 170)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	206	Target Neighborhood Hits	435	Shared Neighborhood Hits	83
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ES8L1_HUMAN
NC score	0.080430 (rank : 171)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	206	Target Neighborhood Hits	162	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ARHG5_HUMAN
NC score	0.078656 (rank : 172)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	206	Target Neighborhood Hits	172	Shared Neighborhood Hits	55
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

EPS8_HUMAN
NC score	0.076295 (rank : 173)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	206	Target Neighborhood Hits	151	Shared Neighborhood Hits	78
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

P85A_HUMAN
NC score	0.076228 (rank : 174)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	206	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

HCK_HUMAN
NC score	0.075490 (rank : 175)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	206	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.074918 (rank : 176)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	206	Target Neighborhood Hits	1033	Shared Neighborhood Hits	113
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_MOUSE
NC score	0.074449 (rank : 177)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	206	Target Neighborhood Hits	1029	Shared Neighborhood Hits	123
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

NGEF_HUMAN
NC score	0.073815 (rank : 178)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	206	Target Neighborhood Hits	166	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FRK_HUMAN
NC score	0.073210 (rank : 179)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	206	Target Neighborhood Hits	1058	Shared Neighborhood Hits	123
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

M3K11_HUMAN
NC score	0.072963 (rank : 180)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	206	Target Neighborhood Hits	1136	Shared Neighborhood Hits	134
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SNX9_MOUSE
NC score	0.072066 (rank : 181)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	206	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

NGEF_MOUSE
NC score	0.072040 (rank : 182)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	206	Target Neighborhood Hits	228	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RASA1_HUMAN
NC score	0.071609 (rank : 183)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	206	Target Neighborhood Hits	258	Shared Neighborhood Hits	47
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHAN2_MOUSE
NC score	0.069582 (rank : 184)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	206	Target Neighborhood Hits	446	Shared Neighborhood Hits	87
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

LYN_MOUSE
NC score	0.068840 (rank : 185)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	206	Target Neighborhood Hits	1023	Shared Neighborhood Hits	109
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BLK_HUMAN
NC score	0.068702 (rank : 186)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	206	Target Neighborhood Hits	994	Shared Neighborhood Hits	97
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ARHGG_MOUSE
NC score	0.068538 (rank : 187)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	39
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BLK_MOUSE
NC score	0.067937 (rank : 188)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	206	Target Neighborhood Hits	992	Shared Neighborhood Hits	91
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_HUMAN
NC score	0.067297 (rank : 189)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	206	Target Neighborhood Hits	1022	Shared Neighborhood Hits	111
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K9_HUMAN
NC score	0.065886 (rank : 190)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	206	Target Neighborhood Hits	1123	Shared Neighborhood Hits	127
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

PPIP2_HUMAN
NC score	0.065377 (rank : 191)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	206	Target Neighborhood Hits	254	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

STS1_HUMAN
NC score	0.064783 (rank : 192)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	206	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

DOCK1_HUMAN
NC score	0.064672 (rank : 193)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	206	Target Neighborhood Hits	191	Shared Neighborhood Hits	75
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

STS1_MOUSE
NC score	0.063974 (rank : 194)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	206	Target Neighborhood Hits	104	Shared Neighborhood Hits	51
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SH21B_MOUSE
NC score	0.063425 (rank : 195)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_MOUSE
NC score	0.063411 (rank : 196)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	206	Target Neighborhood Hits	980	Shared Neighborhood Hits	103
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TEC_MOUSE
NC score	0.063242 (rank : 197)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	102
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_HUMAN
NC score	0.063200 (rank : 198)	θ value	6.88961 (rank : 187)
Query Neighborhood Hits	206	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RM49_HUMAN
NC score	0.063188 (rank : 199)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	206	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q13405	Gene names	MRPL49, C11orf4, NOF1
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49) (Protein NOF1) (Neighbor of FAU) (NOF).

M3K10_HUMAN
NC score	0.063145 (rank : 200)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	206	Target Neighborhood Hits	1071	Shared Neighborhood Hits	118
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

AMPH_MOUSE
NC score	0.063102 (rank : 201)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	59
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

RFIP1_MOUSE
NC score	0.062909 (rank : 202)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	206	Target Neighborhood Hits	152	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SH21B_HUMAN
NC score	0.061431 (rank : 203)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	206	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PPIP2_MOUSE
NC score	0.061156 (rank : 204)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	206	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

LCK_HUMAN
NC score	0.060700 (rank : 205)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	206	Target Neighborhood Hits	987	Shared Neighborhood Hits	83
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BIN1_HUMAN
NC score	0.060296 (rank : 206)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	206	Target Neighborhood Hits	335	Shared Neighborhood Hits	58
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

LCK_MOUSE
NC score	0.059751 (rank : 207)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	206	Target Neighborhood Hits	981	Shared Neighborhood Hits	82
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

ARHGG_HUMAN
NC score	0.059716 (rank : 208)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	206	Target Neighborhood Hits	129	Shared Neighborhood Hits	27
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

P85B_HUMAN
NC score	0.059399 (rank : 209)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	206	Target Neighborhood Hits	543	Shared Neighborhood Hits	59
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SHAN1_HUMAN
NC score	0.059308 (rank : 210)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	206	Target Neighborhood Hits	1041	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

MPP5_HUMAN
NC score	0.059231 (rank : 211)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	206	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PTK6_MOUSE
NC score	0.059079 (rank : 212)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	206	Target Neighborhood Hits	1026	Shared Neighborhood Hits	109
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

MPP5_MOUSE
NC score	0.058778 (rank : 213)	θ value	1.06291 (rank : 110)
Query Neighborhood Hits	206	Target Neighborhood Hits	226	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

ABL1_MOUSE
NC score	0.058730 (rank : 214)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	206	Target Neighborhood Hits	1178	Shared Neighborhood Hits	92
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.058311 (rank : 215)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	206	Target Neighborhood Hits	1220	Shared Neighborhood Hits	94
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ITK_HUMAN
NC score	0.058253 (rank : 216)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	206	Target Neighborhood Hits	1016	Shared Neighborhood Hits	100
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

PTK6_HUMAN
NC score	0.057994 (rank : 217)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	110
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TIAM1_HUMAN
NC score	0.057777 (rank : 218)	θ value	3.0926 (rank : 150)
Query Neighborhood Hits	206	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CSK_MOUSE
NC score	0.057562 (rank : 219)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.057553 (rank : 220)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	206	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BIN1_MOUSE
NC score	0.057527 (rank : 221)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	206	Target Neighborhood Hits	283	Shared Neighborhood Hits	58
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

TXK_HUMAN
NC score	0.056510 (rank : 222)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	92
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABL2_HUMAN
NC score	0.055847 (rank : 223)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	206	Target Neighborhood Hits	1045	Shared Neighborhood Hits	81
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

P85B_MOUSE
NC score	0.055643 (rank : 224)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	206	Target Neighborhood Hits	519	Shared Neighborhood Hits	56
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SLY_MOUSE
NC score	0.055428 (rank : 225)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	206	Target Neighborhood Hits	108	Shared Neighborhood Hits	37
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

ARHG3_HUMAN
NC score	0.054801 (rank : 226)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ITK_MOUSE
NC score	0.054493 (rank : 227)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	206	Target Neighborhood Hits	985	Shared Neighborhood Hits	90
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ARHG3_MOUSE
NC score	0.054297 (rank : 228)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

JIP2_HUMAN
NC score	0.053611 (rank : 229)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	206	Target Neighborhood Hits	288	Shared Neighborhood Hits	44
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ARHG8_HUMAN
NC score	0.053570 (rank : 230)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	206	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MATK_HUMAN
NC score	0.053384 (rank : 231)	θ value	0.125558 (rank : 62)
Query Neighborhood Hits	206	Target Neighborhood Hits	954	Shared Neighborhood Hits	62
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ARHG8_MOUSE
NC score	0.053052 (rank : 232)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	206	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TIAM1_MOUSE
NC score	0.052356 (rank : 233)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	206	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SRMS_MOUSE
NC score	0.051771 (rank : 234)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	206	Target Neighborhood Hits	964	Shared Neighborhood Hits	77
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BCR_HUMAN
NC score	0.051108 (rank : 235)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	206	Target Neighborhood Hits	204	Shared Neighborhood Hits	21
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

NRAP_MOUSE
NC score	0.050342 (rank : 236)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	206	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

RGS3_MOUSE
NC score	0.048351 (rank : 237)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	206	Target Neighborhood Hits	1621	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

B4GN4_HUMAN
NC score	0.048042 (rank : 238)	θ value	0.125558 (rank : 60)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q76KP1, Q96LV2	Gene names	B4GALNT4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

NSD1_MOUSE
NC score	0.045263 (rank : 239)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	206	Target Neighborhood Hits	472	Shared Neighborhood Hits	19
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

S3TC1_HUMAN
NC score	0.045081 (rank : 240)	θ value	1.38821 (rank : 120)
Query Neighborhood Hits	206	Target Neighborhood Hits	78	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TE82	Gene names	SH3TC1
Domain Architecture	No domain graphic available
Description	SH3 domain and tetratricopeptide repeats-containing protein 1.

PSL1_HUMAN
NC score	0.042622 (rank : 241)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	206	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RGS3_HUMAN
NC score	0.040619 (rank : 242)	θ value	0.125558 (rank : 63)
Query Neighborhood Hits	206	Target Neighborhood Hits	1375	Shared Neighborhood Hits	50
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CTDP1_HUMAN
NC score	0.040367 (rank : 243)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	206	Target Neighborhood Hits	416	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

EPHB3_MOUSE
NC score	0.039200 (rank : 244)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	34
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MDC1_HUMAN
NC score	0.039161 (rank : 245)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	206	Target Neighborhood Hits	1446	Shared Neighborhood Hits	56
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SRTD1_MOUSE
NC score	0.038510 (rank : 246)	θ value	4.03905 (rank : 158)
Query Neighborhood Hits	206	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

CDSN_MOUSE
NC score	0.037651 (rank : 247)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	206	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

B4GN4_MOUSE
NC score	0.037270 (rank : 248)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	206	Target Neighborhood Hits	129	Shared Neighborhood Hits	10
SwissProt Accessions	Q766D5, Q8CHV2	Gene names	B4galnt4
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 1 (EC 2.4.1.244) (NGalNAc-T1) (Beta- 1,4-N-acetylgalactosaminyltransferase IV) (Beta4GalNAc-T4) (Beta4GalNAcT4).

NDUAC_HUMAN
NC score	0.036154 (rank : 249)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	206	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UI09, Q9BRV6	Gene names	NDUFA12, DAP13
Domain Architecture
Description	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (EC 1.6.5.3) (EC 1.6.99.3) (NADH-ubiquinone oxidoreductase subunit B17.2) (Complex I-B17.2) (CI-B17.2) (CIB17.2) (13 kDa differentiation- associated protein).

EPHB3_HUMAN
NC score	0.036074 (rank : 250)	θ value	0.365318 (rank : 77)
Query Neighborhood Hits	206	Target Neighborhood Hits	996	Shared Neighborhood Hits	35
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

SOX13_HUMAN
NC score	0.035580 (rank : 251)	θ value	0.0431538 (rank : 47)
Query Neighborhood Hits	206	Target Neighborhood Hits	464	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

PCLO_MOUSE
NC score	0.034312 (rank : 252)	θ value	3.0926 (rank : 148)
Query Neighborhood Hits	206	Target Neighborhood Hits	2275	Shared Neighborhood Hits	76
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

GON4L_HUMAN
NC score	0.033545 (rank : 253)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	206	Target Neighborhood Hits	555	Shared Neighborhood Hits	20
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

RM49_MOUSE
NC score	0.030653 (rank : 254)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	206	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQ40, Q3UC21, Q8C5R0, Q8C7P3	Gene names	Mrpl49
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49).

LIMD1_MOUSE
NC score	0.030152 (rank : 255)	θ value	0.21417 (rank : 72)
Query Neighborhood Hits	206	Target Neighborhood Hits	291	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QXD8, Q8C8G4, Q9CW55	Gene names	Limd1
Domain Architecture
Description	LIM domain-containing protein 1.

NRX2B_HUMAN
NC score	0.029737 (rank : 256)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	206	Target Neighborhood Hits	481	Shared Neighborhood Hits	18
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

MLL4_HUMAN
NC score	0.029365 (rank : 257)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	206	Target Neighborhood Hits	722	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

ARAF_HUMAN
NC score	0.027302 (rank : 258)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	206	Target Neighborhood Hits	924	Shared Neighborhood Hits	32
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

WASP_HUMAN
NC score	0.027283 (rank : 259)	θ value	5.27518 (rank : 174)
Query Neighborhood Hits	206	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

NCOR2_MOUSE
NC score	0.026875 (rank : 260)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	206	Target Neighborhood Hits	790	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NCOR2_HUMAN
NC score	0.026752 (rank : 261)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	206	Target Neighborhood Hits	870	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

MUC5B_HUMAN
NC score	0.025901 (rank : 262)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	206	Target Neighborhood Hits	1020	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CCD27_MOUSE
NC score	0.025569 (rank : 263)	θ value	1.38821 (rank : 115)
Query Neighborhood Hits	206	Target Neighborhood Hits	461	Shared Neighborhood Hits	11
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CSKI1_HUMAN
NC score	0.024496 (rank : 264)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	206	Target Neighborhood Hits	997	Shared Neighborhood Hits	61
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MYLK_HUMAN
NC score	0.024156 (rank : 265)	θ value	0.0563607 (rank : 50)
Query Neighborhood Hits	206	Target Neighborhood Hits	1328	Shared Neighborhood Hits	38
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

ARS2_HUMAN
NC score	0.023444 (rank : 266)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	206	Target Neighborhood Hits	186	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BXP5, O95808, Q9BWP6, Q9BXP4	Gene names	ARS2, ASR2
Domain Architecture
Description	Arsenite-resistance protein 2.

MYLK_MOUSE
NC score	0.023075 (rank : 267)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	206	Target Neighborhood Hits	1489	Shared Neighborhood Hits	43
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

HIRP3_HUMAN
NC score	0.022147 (rank : 268)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	206	Target Neighborhood Hits	323	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

TRIPC_HUMAN
NC score	0.021730 (rank : 269)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	206	Target Neighborhood Hits	319	Shared Neighborhood Hits	12
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

TGON1_MOUSE
NC score	0.020476 (rank : 270)	θ value	6.88961 (rank : 188)
Query Neighborhood Hits	206	Target Neighborhood Hits	243	Shared Neighborhood Hits	12
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

CEP35_HUMAN
NC score	0.020062 (rank : 271)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	206	Target Neighborhood Hits	811	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

NRX2A_HUMAN
NC score	0.020011 (rank : 272)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	206	Target Neighborhood Hits	614	Shared Neighborhood Hits	18
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

MINT_HUMAN
NC score	0.019750 (rank : 273)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	206	Target Neighborhood Hits	1291	Shared Neighborhood Hits	38
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ROBO1_HUMAN
NC score	0.019434 (rank : 274)	θ value	0.62314 (rank : 87)
Query Neighborhood Hits	206	Target Neighborhood Hits	529	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO4_MOUSE
NC score	0.019395 (rank : 275)	θ value	3.0926 (rank : 149)
Query Neighborhood Hits	206	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

DAAM2_HUMAN
NC score	0.019055 (rank : 276)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	206	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

EFHB_MOUSE
NC score	0.018933 (rank : 277)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	206	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

SF3B1_MOUSE
NC score	0.018749 (rank : 278)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	206	Target Neighborhood Hits	352	Shared Neighborhood Hits	14
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

GNDS_HUMAN
NC score	0.018327 (rank : 279)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	206	Target Neighborhood Hits	201	Shared Neighborhood Hits	13
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

ROBO1_MOUSE
NC score	0.017848 (rank : 280)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	206	Target Neighborhood Hits	559	Shared Neighborhood Hits	13
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

S28A1_HUMAN
NC score	0.017318 (rank : 281)	θ value	4.03905 (rank : 156)
Query Neighborhood Hits	206	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O00337, O00335, O00336, Q9UEZ9	Gene names	SLC28A1, CNT1
Domain Architecture
Description	Sodium/nucleoside cotransporter 1 (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1).

MBD5_HUMAN
NC score	0.017085 (rank : 282)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	206	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

SF3B1_HUMAN
NC score	0.016818 (rank : 283)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	206	Target Neighborhood Hits	341	Shared Neighborhood Hits	13
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

F120A_HUMAN
NC score	0.015488 (rank : 284)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	206	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZB2, O60649, Q14688, Q4VXF4, Q4VXF5, Q4VXG2, Q96I21, Q9NZB1	Gene names	FAM120A, C9orf10, KIAA0183
Domain Architecture	No domain graphic available
Description	UPF0318 protein FAM120A.

DYH5_MOUSE
NC score	0.015140 (rank : 285)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	206	Target Neighborhood Hits	286	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VHE6, Q8BWG1	Gene names	Dnah5, Dnahc5
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (Mdnah5).

TDRKH_MOUSE
NC score	0.014829 (rank : 286)	θ value	8.99809 (rank : 206)
Query Neighborhood Hits	206	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

MAST4_HUMAN
NC score	0.014815 (rank : 287)	θ value	1.38821 (rank : 116)
Query Neighborhood Hits	206	Target Neighborhood Hits	1804	Shared Neighborhood Hits	63
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

EAN57_HUMAN
NC score	0.014573 (rank : 288)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	206	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	O43247, Q6ICF2, Q9Y4V8	Gene names	EAN57
Domain Architecture	No domain graphic available
Description	Protein EAN57.

MBP_MOUSE
NC score	0.013851 (rank : 289)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	206	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P04370, Q01585, Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1	Gene names	Mbp, Shi
Domain Architecture
Description	Myelin basic protein (MBP) (Myelin A1 protein).

GIDRP_MOUSE
NC score	0.013737 (rank : 290)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	206	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJM3, Q3UGJ8, Q5U5U8	Gene names	Gidrp88, D19Ertd386e
Domain Architecture	No domain graphic available
Description	Growth inhibition and differentiation-related protein 88 homolog.

SRCA_HUMAN
NC score	0.013677 (rank : 291)	θ value	5.27518 (rank : 173)
Query Neighborhood Hits	206	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

ADNP_HUMAN
NC score	0.013493 (rank : 292)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	206	Target Neighborhood Hits	265	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2P0, O94881, Q9UG34	Gene names	ADNP, KIAA0784
Domain Architecture
Description	Activity-dependent neuroprotector (Activity-dependent neuroprotective protein).

SAPS3_MOUSE
NC score	0.012120 (rank : 293)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	206	Target Neighborhood Hits	77	Shared Neighborhood Hits	6
SwissProt Accessions	Q922D4, Q6ZPM9, Q8BTW6, Q9D2X9	Gene names	Saps3, D19Ertd703e, Kiaa1558
Domain Architecture	No domain graphic available
Description	SAPS domain family member 3.

WHRN_HUMAN
NC score	0.010928 (rank : 294)	θ value	6.88961 (rank : 189)
Query Neighborhood Hits	206	Target Neighborhood Hits	325	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

MYOD1_MOUSE
NC score	0.009993 (rank : 295)	θ value	6.88961 (rank : 185)
Query Neighborhood Hits	206	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MICA3_HUMAN
NC score	0.009679 (rank : 296)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	206	Target Neighborhood Hits	160	Shared Neighborhood Hits	7
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

MATR3_MOUSE
NC score	0.009257 (rank : 297)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	206	Target Neighborhood Hits	321	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K310	Gene names	Matr3
Domain Architecture	No domain graphic available
Description	Matrin-3.

LNX1_HUMAN
NC score	0.008860 (rank : 298)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	206	Target Neighborhood Hits	379	Shared Neighborhood Hits	7
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

NOTC3_MOUSE
NC score	0.007407 (rank : 299)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	206	Target Neighborhood Hits	975	Shared Neighborhood Hits	23
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SI1L3_HUMAN
NC score	0.006826 (rank : 300)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	206	Target Neighborhood Hits	305	Shared Neighborhood Hits	11
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

KI21A_MOUSE
NC score	0.004392 (rank : 301)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	206	Target Neighborhood Hits	1317	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

GLI3_HUMAN
NC score	0.003106 (rank : 302)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	206	Target Neighborhood Hits	871	Shared Neighborhood Hits	11
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

ATS13_HUMAN
NC score	0.002295 (rank : 303)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	206	Target Neighborhood Hits	238	Shared Neighborhood Hits	4
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

DSC1_HUMAN
NC score	0.001054 (rank : 304)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	206	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	Q08554	Gene names	DSC1
Domain Architecture
Description	Desmocollin-1 precursor (Desmosomal glycoprotein 2/3) (DG2/DG3).

GLI2_HUMAN
NC score	-0.001394 (rank : 305)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	206	Target Neighborhood Hits	971	Shared Neighborhood Hits	11
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).