Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : NOXO1_HUMAN

For an explanation of this page, click here

NOXO1_HUMAN
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NOXO1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	1.09426e-130 (rank : 2)	NC score	0.946068 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	114	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NCF1_HUMAN
θ value	9.87957e-23 (rank : 3)	NC score	0.652696 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	86
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	2.20094e-22 (rank : 4)	NC score	0.664970 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	88
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ITSN1_MOUSE
θ value	2.21117e-06 (rank : 5)	NC score	0.247668 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	1669	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
θ value	1.87187e-05 (rank : 6)	NC score	0.242262 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	1757	Shared Neighborhood Hits	89
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
θ value	2.44474e-05 (rank : 7)	NC score	0.265984 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	1173	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	7.1131e-05 (rank : 8)	NC score	0.253913 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	1371	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCK2_HUMAN
θ value	0.000158464 (rank : 9)	NC score	0.311958 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

M3K11_HUMAN
θ value	0.000270298 (rank : 10)	NC score	0.086934 (rank : 152)
Query Neighborhood Hits	100	Target Neighborhood Hits	1136	Shared Neighborhood Hits	84
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NCK1_HUMAN
θ value	0.000786445 (rank : 11)	NC score	0.308675 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRKL_HUMAN
θ value	0.00175202 (rank : 12)	NC score	0.285651 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	313	Shared Neighborhood Hits	86
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.00175202 (rank : 13)	NC score	0.279207 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

M3K9_HUMAN
θ value	0.00509761 (rank : 14)	NC score	0.086807 (rank : 153)
Query Neighborhood Hits	100	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SHAN1_HUMAN
θ value	0.00869519 (rank : 15)	NC score	0.125745 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	1041	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ASPP1_MOUSE
θ value	0.0148317 (rank : 16)	NC score	0.159355 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	1244	Shared Neighborhood Hits	86
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.160275 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	956	Shared Neighborhood Hits	83
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MYO1E_HUMAN
θ value	0.0252991 (rank : 18)	NC score	0.127368 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	88
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

FRK_HUMAN
θ value	0.0330416 (rank : 19)	NC score	0.061438 (rank : 194)
Query Neighborhood Hits	100	Target Neighborhood Hits	1058	Shared Neighborhood Hits	87
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GRAP2_MOUSE
θ value	0.0431538 (rank : 20)	NC score	0.259919 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	297	Shared Neighborhood Hits	89
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

HCLS1_MOUSE
θ value	0.0431538 (rank : 21)	NC score	0.270834 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	329	Shared Neighborhood Hits	86
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

RHG04_HUMAN
θ value	0.0431538 (rank : 22)	NC score	0.152813 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ARHG4_HUMAN
θ value	0.0563607 (rank : 23)	NC score	0.207113 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	242	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CRK_MOUSE
θ value	0.0563607 (rank : 24)	NC score	0.256506 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	314	Shared Neighborhood Hits	86
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_HUMAN
θ value	0.0563607 (rank : 25)	NC score	0.257368 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	304	Shared Neighborhood Hits	89
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

M3KL4_HUMAN
θ value	0.0563607 (rank : 26)	NC score	0.087698 (rank : 150)
Query Neighborhood Hits	100	Target Neighborhood Hits	1087	Shared Neighborhood Hits	85
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PPIP1_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.273258 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	377	Shared Neighborhood Hits	87
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STAC3_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.265112 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.0736092 (rank : 29)	NC score	0.266685 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	232	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

EFS_MOUSE
θ value	0.0961366 (rank : 30)	NC score	0.204228 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	389	Shared Neighborhood Hits	76
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

HCLS1_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.266552 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	358	Shared Neighborhood Hits	86
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

CRK_HUMAN
θ value	0.21417 (rank : 32)	NC score	0.250821 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ES8L3_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.174852 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	0.21417 (rank : 34)	NC score	0.194203 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	68
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3K10_HUMAN
θ value	0.21417 (rank : 35)	NC score	0.071542 (rank : 169)
Query Neighborhood Hits	100	Target Neighborhood Hits	1071	Shared Neighborhood Hits	79
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MIS_HUMAN
θ value	0.21417 (rank : 36)	NC score	0.050067 (rank : 235)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	P03971, O75246	Gene names	AMH, MIF
Domain Architecture
Description	Muellerian-inhibiting factor precursor (MIS) (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance).

MYO1F_HUMAN
θ value	0.21417 (rank : 37)	NC score	0.117981 (rank : 119)
Query Neighborhood Hits	100	Target Neighborhood Hits	275	Shared Neighborhood Hits	87
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

TCGAP_HUMAN
θ value	0.21417 (rank : 38)	NC score	0.115022 (rank : 121)
Query Neighborhood Hits	100	Target Neighborhood Hits	872	Shared Neighborhood Hits	66
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TFEB_HUMAN
θ value	0.21417 (rank : 39)	NC score	0.041630 (rank : 236)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

PLCG1_MOUSE
θ value	0.47712 (rank : 40)	NC score	0.183319 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	314	Shared Neighborhood Hits	77
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DNMBP_MOUSE
θ value	0.62314 (rank : 41)	NC score	0.238919 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	435	Shared Neighborhood Hits	90
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SH3K1_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.308161 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	341	Shared Neighborhood Hits	86
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	0.62314 (rank : 43)	NC score	0.302045 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	332	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SPN90_HUMAN
θ value	0.62314 (rank : 44)	NC score	0.147463 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ABI2_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.240515 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ARHG9_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.205901 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.813845 (rank : 47)	NC score	0.204271 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	234	Shared Neighborhood Hits	78
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PPIP1_HUMAN
θ value	0.813845 (rank : 48)	NC score	0.260532 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	389	Shared Neighborhood Hits	87
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

BCAR1_MOUSE
θ value	1.06291 (rank : 49)	NC score	0.210448 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	438	Shared Neighborhood Hits	84
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

TCGAP_MOUSE
θ value	1.06291 (rank : 50)	NC score	0.126504 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	409	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DNMBP_HUMAN
θ value	1.38821 (rank : 51)	NC score	0.237097 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	413	Shared Neighborhood Hits	89
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PLCG2_HUMAN
θ value	1.38821 (rank : 52)	NC score	0.168869 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	280	Shared Neighborhood Hits	77
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SPTA1_HUMAN
θ value	1.38821 (rank : 53)	NC score	0.094375 (rank : 143)
Query Neighborhood Hits	100	Target Neighborhood Hits	748	Shared Neighborhood Hits	84
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ABI2_MOUSE
θ value	1.81305 (rank : 54)	NC score	0.240226 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	266	Shared Neighborhood Hits	85
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARHG4_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.177500 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCAR1_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.203946 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	554	Shared Neighborhood Hits	84
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CD2AP_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.299603 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	336	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DGLA_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.033477 (rank : 237)
Query Neighborhood Hits	100	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4D2, Q6WQJ0	Gene names	NSDDR, C11orf11, KIAA0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

GRAP_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.228293 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	89
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NPHP1_MOUSE
θ value	1.81305 (rank : 60)	NC score	0.237801 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	267	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SPTA2_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.105353 (rank : 131)
Query Neighborhood Hits	100	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAM1_MOUSE
θ value	1.81305 (rank : 62)	NC score	0.225199 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	273	Shared Neighborhood Hits	88
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG6_MOUSE
θ value	2.36792 (rank : 63)	NC score	0.236281 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	394	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MAGI2_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.014699 (rank : 242)
Query Neighborhood Hits	100	Target Neighborhood Hits	373	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MYO1F_MOUSE
θ value	2.36792 (rank : 65)	NC score	0.114945 (rank : 122)
Query Neighborhood Hits	100	Target Neighborhood Hits	262	Shared Neighborhood Hits	88
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PLCG1_HUMAN
θ value	2.36792 (rank : 66)	NC score	0.173613 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SPN90_MOUSE
θ value	2.36792 (rank : 67)	NC score	0.133751 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

STAM1_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.224521 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	271	Shared Neighborhood Hits	88
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

VAV2_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.171251 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	456	Shared Neighborhood Hits	84
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_MOUSE
θ value	3.0926 (rank : 70)	NC score	0.246429 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

LASP1_HUMAN
θ value	3.0926 (rank : 71)	NC score	0.182506 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.178920 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	297	Shared Neighborhood Hits	77
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NPHP1_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.216158 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	288	Shared Neighborhood Hits	75
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CASL_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.193858 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

FYN_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.068769 (rank : 173)
Query Neighborhood Hits	100	Target Neighborhood Hits	1078	Shared Neighborhood Hits	85
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	4.03905 (rank : 76)	NC score	0.069909 (rank : 170)
Query Neighborhood Hits	100	Target Neighborhood Hits	1073	Shared Neighborhood Hits	85
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

STAC_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.223714 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	268	Shared Neighborhood Hits	82
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VINEX_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.233571 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	270	Shared Neighborhood Hits	86
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

AHI1_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.167413 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	537	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.168775 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	496	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NRL_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.016618 (rank : 241)
Query Neighborhood Hits	100	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P54845	Gene names	NRL
Domain Architecture
Description	Neural retina-specific leucine zipper protein (NRL) (D14S46E).

OSTF1_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.190815 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	466	Shared Neighborhood Hits	89
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	5.27518 (rank : 83)	NC score	0.188657 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	467	Shared Neighborhood Hits	89
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RTN1_MOUSE
θ value	5.27518 (rank : 84)	NC score	0.017345 (rank : 240)
Query Neighborhood Hits	100	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

ARBK2_HUMAN
θ value	6.88961 (rank : 85)	NC score	0.008130 (rank : 244)
Query Neighborhood Hits	100	Target Neighborhood Hits	849	Shared Neighborhood Hits	10
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARHG6_HUMAN
θ value	6.88961 (rank : 86)	NC score	0.231834 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.240096 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	347	Shared Neighborhood Hits	87
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CC053_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.029694 (rank : 238)
Query Neighborhood Hits	100	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N290	Gene names	C3orf53
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C3orf53.

DBNL_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.165174 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	306	Shared Neighborhood Hits	77
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

RUSC1_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.133331 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	226	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SRC_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.066651 (rank : 177)
Query Neighborhood Hits	100	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

VAV3_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.160300 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	398	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.159332 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	404	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

BAT3_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.013534 (rank : 243)
Query Neighborhood Hits	100	Target Neighborhood Hits	490	Shared Neighborhood Hits	7
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CASL_MOUSE
θ value	8.99809 (rank : 95)	NC score	0.191465 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CT032_HUMAN
θ value	8.99809 (rank : 96)	NC score	0.205578 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DGLA_MOUSE
θ value	8.99809 (rank : 97)	NC score	0.026689 (rank : 239)
Query Neighborhood Hits	100	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WQJ1, Q6ZQ76	Gene names	Nsddr, Kiaa0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

DOCK1_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.065795 (rank : 179)
Query Neighborhood Hits	100	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PCDA4_MOUSE
θ value	8.99809 (rank : 99)	NC score	0.000753 (rank : 245)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	4
SwissProt Accessions	O88689, Q3UEX3, Q6PAM9, Q8K487, Q8K489	Gene names	Pcdha4, Cnr1
Domain Architecture	No domain graphic available
Description	Protocadherin alpha 4 precursor (PCDH-alpha4).

STAC_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.224280 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.209059 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	257	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.213413 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.169430 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.185404 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AMPH_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.063108 (rank : 187)
Query Neighborhood Hits	100	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.061094 (rank : 196)
Query Neighborhood Hits	100	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.140670 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	175	Shared Neighborhood Hits	80
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.130167 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.072831 (rank : 166)
Query Neighborhood Hits	100	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.062399 (rank : 190)
Query Neighborhood Hits	100	Target Neighborhood Hits	266	Shared Neighborhood Hits	11
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.062045 (rank : 192)
Query Neighborhood Hits	100	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.064051 (rank : 185)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.092828 (rank : 144)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.092274 (rank : 145)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.099727 (rank : 137)
Query Neighborhood Hits	100	Target Neighborhood Hits	172	Shared Neighborhood Hits	48
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.089131 (rank : 148)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.091512 (rank : 146)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.075577 (rank : 162)
Query Neighborhood Hits	100	Target Neighborhood Hits	187	Shared Neighborhood Hits	17
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.079811 (rank : 160)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.075461 (rank : 163)
Query Neighborhood Hits	100	Target Neighborhood Hits	375	Shared Neighborhood Hits	17
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.072569 (rank : 168)
Query Neighborhood Hits	100	Target Neighborhood Hits	351	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.072697 (rank : 167)
Query Neighborhood Hits	100	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.069151 (rank : 171)
Query Neighborhood Hits	100	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.088435 (rank : 149)
Query Neighborhood Hits	100	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.098443 (rank : 139)
Query Neighborhood Hits	100	Target Neighborhood Hits	152	Shared Neighborhood Hits	35
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.108615 (rank : 126)
Query Neighborhood Hits	100	Target Neighborhood Hits	1156	Shared Neighborhood Hits	70
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCR_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.059711 (rank : 199)
Query Neighborhood Hits	100	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.066753 (rank : 176)
Query Neighborhood Hits	100	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.051828 (rank : 224)
Query Neighborhood Hits	100	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BTK_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.054796 (rank : 213)
Query Neighborhood Hits	100	Target Neighborhood Hits	1026	Shared Neighborhood Hits	85
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.052181 (rank : 222)
Query Neighborhood Hits	100	Target Neighborhood Hits	1017	Shared Neighborhood Hits	76
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CD2AP_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.290486 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	315	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DAPP1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.054856 (rank : 212)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.056135 (rank : 209)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.164388 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	244	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DDEF1_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.085726 (rank : 154)
Query Neighborhood Hits	100	Target Neighborhood Hits	592	Shared Neighborhood Hits	71
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.073722 (rank : 165)
Query Neighborhood Hits	100	Target Neighborhood Hits	599	Shared Neighborhood Hits	72
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.074858 (rank : 164)
Query Neighborhood Hits	100	Target Neighborhood Hits	625	Shared Neighborhood Hits	71
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ECT2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.060152 (rank : 198)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.062635 (rank : 188)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EFS_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.180833 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	348	Shared Neighborhood Hits	75
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EPS8_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.095888 (rank : 141)
Query Neighborhood Hits	100	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.094884 (rank : 142)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.105153 (rank : 132)
Query Neighborhood Hits	100	Target Neighborhood Hits	162	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.106904 (rank : 129)
Query Neighborhood Hits	100	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.109228 (rank : 125)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.102469 (rank : 135)
Query Neighborhood Hits	100	Target Neighborhood Hits	169	Shared Neighborhood Hits	61
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FGD2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.054082 (rank : 217)
Query Neighborhood Hits	100	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.051441 (rank : 228)
Query Neighborhood Hits	100	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.054455 (rank : 215)
Query Neighborhood Hits	100	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.056650 (rank : 208)
Query Neighborhood Hits	100	Target Neighborhood Hits	257	Shared Neighborhood Hits	16
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.055270 (rank : 211)
Query Neighborhood Hits	100	Target Neighborhood Hits	219	Shared Neighborhood Hits	17
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.053306 (rank : 219)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.051670 (rank : 225)
Query Neighborhood Hits	100	Target Neighborhood Hits	282	Shared Neighborhood Hits	17
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGR_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.066904 (rank : 175)
Query Neighborhood Hits	100	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.066972 (rank : 174)
Query Neighborhood Hits	100	Target Neighborhood Hits	1069	Shared Neighborhood Hits	84
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FNBP2_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.099835 (rank : 136)
Query Neighborhood Hits	100	Target Neighborhood Hits	432	Shared Neighborhood Hits	73
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GNRP_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.051087 (rank : 230)
Query Neighborhood Hits	100	Target Neighborhood Hits	239	Shared Neighborhood Hits	14
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.057738 (rank : 205)
Query Neighborhood Hits	100	Target Neighborhood Hits	191	Shared Neighborhood Hits	19
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRAP_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.227210 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.212948 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.212780 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	312	Shared Neighborhood Hits	88
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HAPIP_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.054498 (rank : 214)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCK_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.054209 (rank : 216)
Query Neighborhood Hits	100	Target Neighborhood Hits	1035	Shared Neighborhood Hits	81
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.052035 (rank : 223)
Query Neighborhood Hits	100	Target Neighborhood Hits	1029	Shared Neighborhood Hits	81
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HSH2D_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.050769 (rank : 231)
Query Neighborhood Hits	100	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.130773 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	688	Shared Neighborhood Hits	77
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.119574 (rank : 118)
Query Neighborhood Hits	100	Target Neighborhood Hits	1024	Shared Neighborhood Hits	78
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LBC_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.064338 (rank : 183)
Query Neighborhood Hits	100	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LYN_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.050084 (rank : 233)
Query Neighborhood Hits	100	Target Neighborhood Hits	1022	Shared Neighborhood Hits	80
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MCF2L_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.098134 (rank : 140)
Query Neighborhood Hits	100	Target Neighborhood Hits	255	Shared Neighborhood Hits	32
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.064228 (rank : 184)
Query Neighborhood Hits	100	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NCF2_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.251921 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	229	Shared Neighborhood Hits	86
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.210965 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	161	Shared Neighborhood Hits	70
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.219138 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.137102 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	457	Shared Neighborhood Hits	77
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.122523 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	420	Shared Neighborhood Hits	81
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.121102 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.125195 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

P85A_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.058933 (rank : 203)
Query Neighborhood Hits	100	Target Neighborhood Hits	479	Shared Neighborhood Hits	42
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.059505 (rank : 201)
Query Neighborhood Hits	100	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.053394 (rank : 218)
Query Neighborhood Hits	100	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.142296 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	320	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.142835 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	283	Shared Neighborhood Hits	82
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.159489 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	339	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.157638 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	382	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.139956 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	385	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.139492 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	380	Shared Neighborhood Hits	81
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.110757 (rank : 123)
Query Neighborhood Hits	100	Target Neighborhood Hits	128	Shared Neighborhood Hits	58
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.104232 (rank : 133)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHG1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.079555 (rank : 161)
Query Neighborhood Hits	100	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PREX1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.084527 (rank : 156)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RASA1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.062604 (rank : 189)
Query Neighborhood Hits	100	Target Neighborhood Hits	258	Shared Neighborhood Hits	30
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.052447 (rank : 220)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.052363 (rank : 221)
Query Neighborhood Hits	100	Target Neighborhood Hits	204	Shared Neighborhood Hits	6
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.065052 (rank : 181)
Query Neighborhood Hits	100	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.063857 (rank : 186)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.062392 (rank : 191)
Query Neighborhood Hits	100	Target Neighborhood Hits	641	Shared Neighborhood Hits	24
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG26_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.080718 (rank : 159)
Query Neighborhood Hits	100	Target Neighborhood Hits	281	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.051256 (rank : 229)
Query Neighborhood Hits	100	Target Neighborhood Hits	1479	Shared Neighborhood Hits	63
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.058931 (rank : 204)
Query Neighborhood Hits	100	Target Neighborhood Hits	1376	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.099108 (rank : 138)
Query Neighborhood Hits	100	Target Neighborhood Hits	263	Shared Neighborhood Hits	55
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.102818 (rank : 134)
Query Neighborhood Hits	100	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.107455 (rank : 128)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.051628 (rank : 226)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH3G1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.151711 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	83
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.148796 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	291	Shared Neighborhood Hits	83
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.157603 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	324	Shared Neighborhood Hits	84
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.158542 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	319	Shared Neighborhood Hits	85
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.151466 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	222	Shared Neighborhood Hits	84
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.164734 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	236	Shared Neighborhood Hits	84
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SHAN2_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.115596 (rank : 120)
Query Neighborhood Hits	100	Target Neighborhood Hits	446	Shared Neighborhood Hits	64
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.050090 (rank : 232)
Query Neighborhood Hits	100	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHLB1_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.062033 (rank : 193)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.059552 (rank : 200)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.055955 (rank : 210)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.057541 (rank : 206)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.061089 (rank : 197)
Query Neighborhood Hits	100	Target Neighborhood Hits	139	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.059241 (rank : 202)
Query Neighborhood Hits	100	Target Neighborhood Hits	136	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.056881 (rank : 207)
Query Neighborhood Hits	100	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.069119 (rank : 172)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX18_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.084647 (rank : 155)
Query Neighborhood Hits	100	Target Neighborhood Hits	207	Shared Neighborhood Hits	68
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.087251 (rank : 151)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	67
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.061181 (rank : 195)
Query Neighborhood Hits	100	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.050072 (rank : 234)
Query Neighborhood Hits	100	Target Neighborhood Hits	141	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPTA1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.091085 (rank : 147)
Query Neighborhood Hits	100	Target Neighborhood Hits	675	Shared Neighborhood Hits	76
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.199316 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.211307 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	409	Shared Neighborhood Hits	84
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.228538 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	269	Shared Neighborhood Hits	84
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.232879 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	292	Shared Neighborhood Hits	84
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.051552 (rank : 227)
Query Neighborhood Hits	100	Target Neighborhood Hits	1033	Shared Neighborhood Hits	77
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRGP1_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.105404 (rank : 130)
Query Neighborhood Hits	100	Target Neighborhood Hits	390	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.108415 (rank : 127)
Query Neighborhood Hits	100	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.109723 (rank : 124)
Query Neighborhood Hits	100	Target Neighborhood Hits	324	Shared Neighborhood Hits	74
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAM2_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.189499 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	288	Shared Neighborhood Hits	84
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.199785 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	285	Shared Neighborhood Hits	85
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STS2_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.066445 (rank : 178)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	36
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TIAM1_HUMAN
θ value	θ > 10 (rank : 238)	NC score	0.083987 (rank : 158)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 239)	NC score	0.084362 (rank : 157)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.167523 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.167419 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	452	Shared Neighborhood Hits	83
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.168731 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	430	Shared Neighborhood Hits	83
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VINEX_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.220245 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YES_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.064942 (rank : 182)
Query Neighborhood Hits	100	Target Neighborhood Hits	1059	Shared Neighborhood Hits	86
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.065482 (rank : 180)
Query Neighborhood Hits	100	Target Neighborhood Hits	1052	Shared Neighborhood Hits	86
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

Hits sorted by NC score

NOXO1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
NC score	0.946068 (rank : 2)	θ value	1.09426e-130 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	114	Shared Neighborhood Hits	75
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NCF1_MOUSE
NC score	0.664970 (rank : 3)	θ value	2.20094e-22 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	88
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.652696 (rank : 4)	θ value	9.87957e-23 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	86
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCK2_HUMAN
NC score	0.311958 (rank : 5)	θ value	0.000158464 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.308675 (rank : 6)	θ value	0.000786445 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3K1_HUMAN
NC score	0.308161 (rank : 7)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	341	Shared Neighborhood Hits	86
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.302045 (rank : 8)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	332	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.299603 (rank : 9)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	336	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.290486 (rank : 10)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	100	Target Neighborhood Hits	315	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CRKL_HUMAN
NC score	0.285651 (rank : 11)	θ value	0.00175202 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	313	Shared Neighborhood Hits	86
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.279207 (rank : 12)	θ value	0.00175202 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PPIP1_MOUSE
NC score	0.273258 (rank : 13)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	377	Shared Neighborhood Hits	87
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

HCLS1_MOUSE
NC score	0.270834 (rank : 14)	θ value	0.0431538 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	329	Shared Neighborhood Hits	86
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAC3_MOUSE
NC score	0.266685 (rank : 15)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	232	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

HCLS1_HUMAN
NC score	0.266552 (rank : 16)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	358	Shared Neighborhood Hits	86
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ITSN2_HUMAN
NC score	0.265984 (rank : 17)	θ value	2.44474e-05 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	1173	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

STAC3_HUMAN
NC score	0.265112 (rank : 18)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	228	Shared Neighborhood Hits	80
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PPIP1_HUMAN
NC score	0.260532 (rank : 19)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	389	Shared Neighborhood Hits	87
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP2_MOUSE
NC score	0.259919 (rank : 20)	θ value	0.0431538 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	297	Shared Neighborhood Hits	89
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.257368 (rank : 21)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	304	Shared Neighborhood Hits	89
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRK_MOUSE
NC score	0.256506 (rank : 22)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	314	Shared Neighborhood Hits	86
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ITSN2_MOUSE
NC score	0.253913 (rank : 23)	θ value	7.1131e-05 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	1371	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCF2_HUMAN
NC score	0.251921 (rank : 24)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	100	Target Neighborhood Hits	229	Shared Neighborhood Hits	86
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CRK_HUMAN
NC score	0.250821 (rank : 25)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ITSN1_MOUSE
NC score	0.247668 (rank : 26)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	1669	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG7_MOUSE
NC score	0.246429 (rank : 27)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN1_HUMAN
NC score	0.242262 (rank : 28)	θ value	1.87187e-05 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	1757	Shared Neighborhood Hits	89
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ABI2_HUMAN
NC score	0.240515 (rank : 29)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.240226 (rank : 30)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	266	Shared Neighborhood Hits	85
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARHG7_HUMAN
NC score	0.240096 (rank : 31)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	347	Shared Neighborhood Hits	87
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

DNMBP_MOUSE
NC score	0.238919 (rank : 32)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	435	Shared Neighborhood Hits	90
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NPHP1_MOUSE
NC score	0.237801 (rank : 33)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	267	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

DNMBP_HUMAN
NC score	0.237097 (rank : 34)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	413	Shared Neighborhood Hits	89
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_MOUSE
NC score	0.236281 (rank : 35)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	394	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

VINEX_HUMAN
NC score	0.233571 (rank : 36)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	270	Shared Neighborhood Hits	86
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SRC8_MOUSE
NC score	0.232879 (rank : 37)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	100	Target Neighborhood Hits	292	Shared Neighborhood Hits	84
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

ARHG6_HUMAN
NC score	0.231834 (rank : 38)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	376	Shared Neighborhood Hits	86
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SRC8_HUMAN
NC score	0.228538 (rank : 39)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	100	Target Neighborhood Hits	269	Shared Neighborhood Hits	84
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GRAP_HUMAN
NC score	0.228293 (rank : 40)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	89
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.227210 (rank : 41)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	100	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAM1_MOUSE
NC score	0.225199 (rank : 42)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	273	Shared Neighborhood Hits	88
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_HUMAN
NC score	0.224521 (rank : 43)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	271	Shared Neighborhood Hits	88
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.224280 (rank : 44)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
NC score	0.223714 (rank : 45)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	268	Shared Neighborhood Hits	82
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VINEX_MOUSE
NC score	0.220245 (rank : 46)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	100	Target Neighborhood Hits	286	Shared Neighborhood Hits	86
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF4_MOUSE
NC score	0.219138 (rank : 47)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	75
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NPHP1_HUMAN
NC score	0.216158 (rank : 48)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	288	Shared Neighborhood Hits	75
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ABI1_MOUSE
NC score	0.213413 (rank : 49)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRB2_HUMAN
NC score	0.212948 (rank : 50)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	100	Target Neighborhood Hits	310	Shared Neighborhood Hits	88
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.212780 (rank : 51)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	100	Target Neighborhood Hits	312	Shared Neighborhood Hits	88
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SRBS1_MOUSE
NC score	0.211307 (rank : 52)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	100	Target Neighborhood Hits	409	Shared Neighborhood Hits	84
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF4_HUMAN
NC score	0.210965 (rank : 53)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	100	Target Neighborhood Hits	161	Shared Neighborhood Hits	70
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

BCAR1_MOUSE
NC score	0.210448 (rank : 54)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	438	Shared Neighborhood Hits	84
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

ABI1_HUMAN
NC score	0.209059 (rank : 55)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	257	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ARHG4_HUMAN
NC score	0.207113 (rank : 56)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	242	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.205901 (rank : 57)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	235	Shared Neighborhood Hits	79
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

CT032_HUMAN
NC score	0.205578 (rank : 58)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ARHG9_MOUSE
NC score	0.204271 (rank : 59)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	234	Shared Neighborhood Hits	78
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

EFS_MOUSE
NC score	0.204228 (rank : 60)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	389	Shared Neighborhood Hits	76
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

BCAR1_HUMAN
NC score	0.203946 (rank : 61)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	554	Shared Neighborhood Hits	84
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STAM2_MOUSE
NC score	0.199785 (rank : 62)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	100	Target Neighborhood Hits	285	Shared Neighborhood Hits	85
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRBS1_HUMAN
NC score	0.199316 (rank : 63)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ES8L3_MOUSE
NC score	0.194203 (rank : 64)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	68
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CASL_HUMAN
NC score	0.193858 (rank : 65)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.191465 (rank : 66)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

OSTF1_HUMAN
NC score	0.190815 (rank : 67)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	466	Shared Neighborhood Hits	89
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

STAM2_HUMAN
NC score	0.189499 (rank : 68)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	100	Target Neighborhood Hits	288	Shared Neighborhood Hits	84
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

OSTF1_MOUSE
NC score	0.188657 (rank : 69)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	467	Shared Neighborhood Hits	89
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ABI3_MOUSE
NC score	0.185404 (rank : 70)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PLCG1_MOUSE
NC score	0.183319 (rank : 71)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	314	Shared Neighborhood Hits	77
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

LASP1_HUMAN
NC score	0.182506 (rank : 72)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	77
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

EFS_HUMAN
NC score	0.180833 (rank : 73)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	100	Target Neighborhood Hits	348	Shared Neighborhood Hits	75
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

LASP1_MOUSE
NC score	0.178920 (rank : 74)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	297	Shared Neighborhood Hits	77
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

ARHG4_MOUSE
NC score	0.177500 (rank : 75)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	185	Shared Neighborhood Hits	64
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ES8L3_HUMAN
NC score	0.174852 (rank : 76)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PLCG1_HUMAN
NC score	0.173613 (rank : 77)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	74
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV2_MOUSE
NC score	0.171251 (rank : 78)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	456	Shared Neighborhood Hits	84
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ABI3_HUMAN
NC score	0.169430 (rank : 79)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PLCG2_HUMAN
NC score	0.168869 (rank : 80)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	280	Shared Neighborhood Hits	77
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

AHI1_MOUSE
NC score	0.168775 (rank : 81)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	496	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

VAV_MOUSE
NC score	0.168731 (rank : 82)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	100	Target Neighborhood Hits	430	Shared Neighborhood Hits	83
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_HUMAN
NC score	0.167523 (rank : 83)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	100	Target Neighborhood Hits	453	Shared Neighborhood Hits	83
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.167419 (rank : 84)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	100	Target Neighborhood Hits	452	Shared Neighborhood Hits	83
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

AHI1_HUMAN
NC score	0.167413 (rank : 85)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	537	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DBNL_MOUSE
NC score	0.165174 (rank : 86)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	306	Shared Neighborhood Hits	77
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SH3G3_MOUSE
NC score	0.164734 (rank : 87)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	100	Target Neighborhood Hits	236	Shared Neighborhood Hits	84
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

DBNL_HUMAN
NC score	0.164388 (rank : 88)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	100	Target Neighborhood Hits	244	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

VAV3_HUMAN
NC score	0.160300 (rank : 89)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	398	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ASPP1_HUMAN
NC score	0.160275 (rank : 90)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	956	Shared Neighborhood Hits	83
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PACN2_HUMAN
NC score	0.159489 (rank : 91)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	100	Target Neighborhood Hits	339	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ASPP1_MOUSE
NC score	0.159355 (rank : 92)	θ value	0.0148317 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	1244	Shared Neighborhood Hits	86
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

VAV3_MOUSE
NC score	0.159332 (rank : 93)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	404	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH3G2_MOUSE
NC score	0.158542 (rank : 94)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	100	Target Neighborhood Hits	319	Shared Neighborhood Hits	85
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PACN2_MOUSE
NC score	0.157638 (rank : 95)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	100	Target Neighborhood Hits	382	Shared Neighborhood Hits	85
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_HUMAN
NC score	0.157603 (rank : 96)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	100	Target Neighborhood Hits	324	Shared Neighborhood Hits	84
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

RHG04_HUMAN
NC score	0.152813 (rank : 97)	θ value	0.0431538 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SH3G1_HUMAN
NC score	0.151711 (rank : 98)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	100	Target Neighborhood Hits	307	Shared Neighborhood Hits	83
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G3_HUMAN
NC score	0.151466 (rank : 99)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	100	Target Neighborhood Hits	222	Shared Neighborhood Hits	84
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G1_MOUSE
NC score	0.148796 (rank : 100)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	100	Target Neighborhood Hits	291	Shared Neighborhood Hits	83
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SPN90_HUMAN
NC score	0.147463 (rank : 101)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

PACN1_MOUSE
NC score	0.142835 (rank : 102)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	100	Target Neighborhood Hits	283	Shared Neighborhood Hits	82
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.142296 (rank : 103)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	100	Target Neighborhood Hits	320	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ANM2_HUMAN
NC score	0.140670 (rank : 104)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	175	Shared Neighborhood Hits	80
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PACN3_HUMAN
NC score	0.139956 (rank : 105)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	100	Target Neighborhood Hits	385	Shared Neighborhood Hits	79
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.139492 (rank : 106)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	100	Target Neighborhood Hits	380	Shared Neighborhood Hits	81
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NEBL_HUMAN
NC score	0.137102 (rank : 107)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	100	Target Neighborhood Hits	457	Shared Neighborhood Hits	77
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SPN90_MOUSE
NC score	0.133751 (rank : 108)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

RUSC1_HUMAN
NC score	0.133331 (rank : 109)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	226	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

IASPP_HUMAN
NC score	0.130773 (rank : 110)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	100	Target Neighborhood Hits	688	Shared Neighborhood Hits	77
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANM2_MOUSE
NC score	0.130167 (rank : 111)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MYO1E_HUMAN
NC score	0.127368 (rank : 112)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	293	Shared Neighborhood Hits	88
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

TCGAP_MOUSE
NC score	0.126504 (rank : 113)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	409	Shared Neighborhood Hits	66
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SHAN1_HUMAN
NC score	0.125745 (rank : 114)	θ value	0.00869519 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	1041	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

NGEF_MOUSE
NC score	0.125195 (rank : 115)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	100	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NEBU_HUMAN
NC score	0.122523 (rank : 116)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	100	Target Neighborhood Hits	420	Shared Neighborhood Hits	81
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
NC score	0.121102 (rank : 117)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	100	Target Neighborhood Hits	166	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

IASPP_MOUSE
NC score	0.119574 (rank : 118)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	100	Target Neighborhood Hits	1024	Shared Neighborhood Hits	78
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYO1F_HUMAN
NC score	0.117981 (rank : 119)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	275	Shared Neighborhood Hits	87
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SHAN2_MOUSE
NC score	0.115596 (rank : 120)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	100	Target Neighborhood Hits	446	Shared Neighborhood Hits	64
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TCGAP_HUMAN
NC score	0.115022 (rank : 121)	θ value	0.21417 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	872	Shared Neighborhood Hits	66
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MYO1F_MOUSE
NC score	0.114945 (rank : 122)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	262	Shared Neighborhood Hits	88
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PEX13_HUMAN
NC score	0.110757 (rank : 123)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	100	Target Neighborhood Hits	128	Shared Neighborhood Hits	58
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SRGP2_MOUSE
NC score	0.109723 (rank : 124)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	100	Target Neighborhood Hits	324	Shared Neighborhood Hits	74
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ES8L2_HUMAN
NC score	0.109228 (rank : 125)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ASPP2_HUMAN
NC score	0.108615 (rank : 126)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	100	Target Neighborhood Hits	1156	Shared Neighborhood Hits	70
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SRGP2_HUMAN
NC score	0.108415 (rank : 127)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	100	Target Neighborhood Hits	331	Shared Neighborhood Hits	74
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RUSC1_MOUSE
NC score	0.107455 (rank : 128)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

ES8L1_MOUSE
NC score	0.106904 (rank : 129)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	100	Target Neighborhood Hits	143	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

SRGP1_HUMAN
NC score	0.105404 (rank : 130)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	100	Target Neighborhood Hits	390	Shared Neighborhood Hits	71
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SPTA2_HUMAN
NC score	0.105353 (rank : 131)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	888	Shared Neighborhood Hits	85
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ES8L1_HUMAN
NC score	0.105153 (rank : 132)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	100	Target Neighborhood Hits	162	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

PEX13_MOUSE
NC score	0.104232 (rank : 133)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	56
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RIMB2_MOUSE
NC score	0.102818 (rank : 134)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	100	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L2_MOUSE
NC score	0.102469 (rank : 135)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	100	Target Neighborhood Hits	169	Shared Neighborhood Hits	61
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FNBP2_HUMAN
NC score	0.099835 (rank : 136)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	100	Target Neighborhood Hits	432	Shared Neighborhood Hits	73
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ARHG5_HUMAN
NC score	0.099727 (rank : 137)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	172	Shared Neighborhood Hits	48
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RIMB2_HUMAN
NC score	0.099108 (rank : 138)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	100	Target Neighborhood Hits	263	Shared Neighborhood Hits	55
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ARHGG_MOUSE
NC score	0.098443 (rank : 139)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	100	Target Neighborhood Hits	152	Shared Neighborhood Hits	35
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
NC score	0.098134 (rank : 140)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	100	Target Neighborhood Hits	255	Shared Neighborhood Hits	32
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

EPS8_HUMAN
NC score	0.095888 (rank : 141)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	100	Target Neighborhood Hits	151	Shared Neighborhood Hits	56
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
NC score	0.094884 (rank : 142)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	100	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SPTA1_HUMAN
NC score	0.094375 (rank : 143)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	748	Shared Neighborhood Hits	84
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ARHG3_HUMAN
NC score	0.092828 (rank : 144)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.092274 (rank : 145)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG8_MOUSE
NC score	0.091512 (rank : 146)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

SPTA1_MOUSE
NC score	0.091085 (rank : 147)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	100	Target Neighborhood Hits	675	Shared Neighborhood Hits	76
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ARHG8_HUMAN
NC score	0.089131 (rank : 148)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	15
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
NC score	0.088435 (rank : 149)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	100	Target Neighborhood Hits	129	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

M3KL4_HUMAN
NC score	0.087698 (rank : 150)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	1087	Shared Neighborhood Hits	85
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SNX18_MOUSE
NC score	0.087251 (rank : 151)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	100	Target Neighborhood Hits	198	Shared Neighborhood Hits	67
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

M3K11_HUMAN
NC score	0.086934 (rank : 152)	θ value	0.000270298 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	1136	Shared Neighborhood Hits	84
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
NC score	0.086807 (rank : 153)	θ value	0.00509761 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	1123	Shared Neighborhood Hits	86
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

DDEF1_MOUSE
NC score	0.085726 (rank : 154)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	100	Target Neighborhood Hits	592	Shared Neighborhood Hits	71
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SNX18_HUMAN
NC score	0.084647 (rank : 155)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	100	Target Neighborhood Hits	207	Shared Neighborhood Hits	68
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PREX1_HUMAN
NC score	0.084527 (rank : 156)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_MOUSE
NC score	0.084362 (rank : 157)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.083987 (rank : 158)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RHG26_HUMAN
NC score	0.080718 (rank : 159)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	100	Target Neighborhood Hits	281	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ARHGA_MOUSE
NC score	0.079811 (rank : 160)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	18
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

PKHG1_HUMAN
NC score	0.079555 (rank : 161)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	100	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_HUMAN
NC score	0.075577 (rank : 162)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	100	Target Neighborhood Hits	187	Shared Neighborhood Hits	17
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
NC score	0.075461 (rank : 163)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	100	Target Neighborhood Hits	375	Shared Neighborhood Hits	17
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DDEF2_MOUSE
NC score	0.074858 (rank : 164)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	100	Target Neighborhood Hits	625	Shared Neighborhood Hits	71
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.073722 (rank : 165)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	100	Target Neighborhood Hits	599	Shared Neighborhood Hits	72
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ARHG1_HUMAN
NC score	0.072831 (rank : 166)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	176	Shared Neighborhood Hits	13
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHGC_MOUSE
NC score	0.072697 (rank : 167)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	100	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.072569 (rank : 168)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	100	Target Neighborhood Hits	351	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

M3K10_HUMAN
NC score	0.071542 (rank : 169)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	1071	Shared Neighborhood Hits	79
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

FYN_MOUSE
NC score	0.069909 (rank : 170)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	1073	Shared Neighborhood Hits	85
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ARHGF_HUMAN
NC score	0.069151 (rank : 171)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	100	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

SLY_MOUSE
NC score	0.069119 (rank : 172)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

FYN_HUMAN
NC score	0.068769 (rank : 173)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	1078	Shared Neighborhood Hits	85
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_MOUSE
NC score	0.066972 (rank : 174)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	100	Target Neighborhood Hits	1069	Shared Neighborhood Hits	84
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_HUMAN
NC score	0.066904 (rank : 175)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	100	Target Neighborhood Hits	1067	Shared Neighborhood Hits	83
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

BI2L1_HUMAN
NC score	0.066753 (rank : 176)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	100	Target Neighborhood Hits	156	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SRC_HUMAN
NC score	0.066651 (rank : 177)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	1058	Shared Neighborhood Hits	85
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

STS2_HUMAN
NC score	0.066445 (rank : 178)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	36
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

DOCK1_HUMAN
NC score	0.065795 (rank : 179)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

YES_MOUSE
NC score	0.065482 (rank : 180)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	100	Target Neighborhood Hits	1052	Shared Neighborhood Hits	86
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

REPS2_HUMAN
NC score	0.065052 (rank : 181)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	100	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

YES_HUMAN
NC score	0.064942 (rank : 182)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	100	Target Neighborhood Hits	1059	Shared Neighborhood Hits	86
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LBC_HUMAN
NC score	0.064338 (rank : 183)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	100	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2_HUMAN
NC score	0.064228 (rank : 184)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	100	Target Neighborhood Hits	166	Shared Neighborhood Hits	19
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG2_MOUSE
NC score	0.064051 (rank : 185)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	17
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

REPS2_MOUSE
NC score	0.063857 (rank : 186)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

AMPH_HUMAN
NC score	0.063108 (rank : 187)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	455	Shared Neighborhood Hits	44
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ECT2_MOUSE
NC score	0.062635 (rank : 188)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RASA1_HUMAN
NC score	0.062604 (rank : 189)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	100	Target Neighborhood Hits	258	Shared Neighborhood Hits	30
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ARHG1_MOUSE
NC score	0.062399 (rank : 190)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	266	Shared Neighborhood Hits	11
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

RGNEF_MOUSE
NC score	0.062392 (rank : 191)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	100	Target Neighborhood Hits	641	Shared Neighborhood Hits	24
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHG2_HUMAN
NC score	0.062045 (rank : 192)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	142	Shared Neighborhood Hits	17
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

SHLB1_HUMAN
NC score	0.062033 (rank : 193)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

FRK_HUMAN
NC score	0.061438 (rank : 194)	θ value	0.0330416 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	1058	Shared Neighborhood Hits	87
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

SNX9_HUMAN
NC score	0.061181 (rank : 195)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	100	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

AMPH_MOUSE
NC score	0.061094 (rank : 196)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	291	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

SLAP2_HUMAN
NC score	0.061089 (rank : 197)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	100	Target Neighborhood Hits	139	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ECT2_HUMAN
NC score	0.060152 (rank : 198)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BCR_HUMAN
NC score	0.059711 (rank : 199)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	100	Target Neighborhood Hits	204	Shared Neighborhood Hits	20
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SHLB1_MOUSE
NC score	0.059552 (rank : 200)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

P85A_MOUSE
NC score	0.059505 (rank : 201)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	100	Target Neighborhood Hits	435	Shared Neighborhood Hits	43
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SLAP2_MOUSE
NC score	0.059241 (rank : 202)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	100	Target Neighborhood Hits	136	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

P85A_HUMAN
NC score	0.058933 (rank : 203)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	100	Target Neighborhood Hits	479	Shared Neighborhood Hits	42
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RIMB1_MOUSE
NC score	0.058931 (rank : 204)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	100	Target Neighborhood Hits	1376	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

GNRP_MOUSE
NC score	0.057738 (rank : 205)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	100	Target Neighborhood Hits	191	Shared Neighborhood Hits	19
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SHLB2_MOUSE
NC score	0.057541 (rank : 206)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLY_HUMAN
NC score	0.056881 (rank : 207)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	100	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

FGD3_MOUSE
NC score	0.056650 (rank : 208)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	100	Target Neighborhood Hits	257	Shared Neighborhood Hits	16
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

DAPP1_MOUSE
NC score	0.056135 (rank : 209)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	100	Target Neighborhood Hits	225	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SHLB2_HUMAN
NC score	0.055955 (rank : 210)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

FGD4_HUMAN
NC score	0.055270 (rank : 211)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	100	Target Neighborhood Hits	219	Shared Neighborhood Hits	17
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

DAPP1_HUMAN
NC score	0.054856 (rank : 212)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

BTK_HUMAN
NC score	0.054796 (rank : 213)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	100	Target Neighborhood Hits	1026	Shared Neighborhood Hits	85
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

HAPIP_HUMAN
NC score	0.054498 (rank : 214)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	18
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD3_HUMAN
NC score	0.054455 (rank : 215)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	100	Target Neighborhood Hits	249	Shared Neighborhood Hits	16
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

HCK_HUMAN
NC score	0.054209 (rank : 216)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	100	Target Neighborhood Hits	1035	Shared Neighborhood Hits	81
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FGD2_HUMAN
NC score	0.054082 (rank : 217)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	100	Target Neighborhood Hits	151	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

P85B_HUMAN
NC score	0.053394 (rank : 218)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	100	Target Neighborhood Hits	543	Shared Neighborhood Hits	35
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FGD4_MOUSE
NC score	0.053306 (rank : 219)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	17
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

REPS1_HUMAN
NC score	0.052447 (rank : 220)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	5
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
NC score	0.052363 (rank : 221)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	100	Target Neighborhood Hits	204	Shared Neighborhood Hits	6
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

BTK_MOUSE
NC score	0.052181 (rank : 222)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	100	Target Neighborhood Hits	1017	Shared Neighborhood Hits	76
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

HCK_MOUSE
NC score	0.052035 (rank : 223)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	100	Target Neighborhood Hits	1029	Shared Neighborhood Hits	81
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

BI2L1_MOUSE
NC score	0.051828 (rank : 224)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	100	Target Neighborhood Hits	197	Shared Neighborhood Hits	22
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

FGD6_MOUSE
NC score	0.051670 (rank : 225)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	100	Target Neighborhood Hits	282	Shared Neighborhood Hits	17
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

RUSC2_HUMAN
NC score	0.051628 (rank : 226)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	100	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SRC_MOUSE
NC score	0.051552 (rank : 227)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	100	Target Neighborhood Hits	1033	Shared Neighborhood Hits	77
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FGD2_MOUSE
NC score	0.051441 (rank : 228)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	100	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

RIMB1_HUMAN
NC score	0.051256 (rank : 229)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	100	Target Neighborhood Hits	1479	Shared Neighborhood Hits	63
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

GNRP_HUMAN
NC score	0.051087 (rank : 230)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	100	Target Neighborhood Hits	239	Shared Neighborhood Hits	14
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

HSH2D_HUMAN
NC score	0.050769 (rank : 231)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	100	Target Neighborhood Hits	159	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SHB_MOUSE
NC score	0.050090 (rank : 232)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	100	Target Neighborhood Hits	137	Shared Neighborhood Hits	19
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

LYN_HUMAN
NC score	0.050084 (rank : 233)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	100	Target Neighborhood Hits	1022	Shared Neighborhood Hits	80
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SNX9_MOUSE
NC score	0.050072 (rank : 234)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	100	Target Neighborhood Hits	141	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

MIS_HUMAN
NC score	0.050067 (rank : 235)	θ value	0.21417 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	P03971, O75246	Gene names	AMH, MIF
Domain Architecture
Description	Muellerian-inhibiting factor precursor (MIS) (Anti-Muellerian hormone) (AMH) (Muellerian-inhibiting substance).

TFEB_HUMAN
NC score	0.041630 (rank : 236)	θ value	0.21417 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

DGLA_HUMAN
NC score	0.033477 (rank : 237)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4D2, Q6WQJ0	Gene names	NSDDR, C11orf11, KIAA0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

CC053_HUMAN
NC score	0.029694 (rank : 238)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N290	Gene names	C3orf53
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C3orf53.

DGLA_MOUSE
NC score	0.026689 (rank : 239)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WQJ1, Q6ZQ76	Gene names	Nsddr, Kiaa0659
Domain Architecture	No domain graphic available
Description	Sn1-specific diacylglycerol lipase alpha (EC 3.1.1.-) (DGL-alpha) (Neural stem cell-derived dendrite regulator).

RTN1_MOUSE
NC score	0.017345 (rank : 240)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	189	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

NRL_HUMAN
NC score	0.016618 (rank : 241)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P54845	Gene names	NRL
Domain Architecture
Description	Neural retina-specific leucine zipper protein (NRL) (D14S46E).

MAGI2_HUMAN
NC score	0.014699 (rank : 242)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	373	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

BAT3_HUMAN
NC score	0.013534 (rank : 243)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	490	Shared Neighborhood Hits	7
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

ARBK2_HUMAN
NC score	0.008130 (rank : 244)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	849	Shared Neighborhood Hits	10
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

PCDA4_MOUSE
NC score	0.000753 (rank : 245)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	4
SwissProt Accessions	O88689, Q3UEX3, Q6PAM9, Q8K487, Q8K489	Gene names	Pcdha4, Cnr1
Domain Architecture	No domain graphic available
Description	Protocadherin alpha 4 precursor (PCDH-alpha4).