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Network neighborhood for query Sequence : SRGP1_HUMAN

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SRGP1_HUMAN
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FNBP2_HUMAN
θ value	0 (rank : 1)	NC score	0.961333 (rank : 4)
Query Neighborhood Hits	390	Target Neighborhood Hits	432	Shared Neighborhood Hits	271
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG04_HUMAN
θ value	0 (rank : 2)	NC score	0.947787 (rank : 5)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	209
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	390	Target Neighborhood Hits	390	Shared Neighborhood Hits	390
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	0 (rank : 4)	NC score	0.973188 (rank : 3)
Query Neighborhood Hits	390	Target Neighborhood Hits	331	Shared Neighborhood Hits	240
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	0 (rank : 5)	NC score	0.974120 (rank : 2)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	244
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

CHIO_MOUSE
θ value	6.18819e-25 (rank : 6)	NC score	0.687599 (rank : 16)
Query Neighborhood Hits	390	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_HUMAN
θ value	1.37858e-24 (rank : 7)	NC score	0.673897 (rank : 20)
Query Neighborhood Hits	390	Target Neighborhood Hits	220	Shared Neighborhood Hits	97
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
θ value	8.93572e-24 (rank : 8)	NC score	0.673169 (rank : 21)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	96
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	8.93572e-24 (rank : 9)	NC score	0.676814 (rank : 19)
Query Neighborhood Hits	390	Target Neighborhood Hits	229	Shared Neighborhood Hits	101
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

GRLF1_HUMAN
θ value	1.86321e-21 (rank : 10)	NC score	0.687666 (rank : 15)
Query Neighborhood Hits	390	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

RHG12_MOUSE
θ value	4.58923e-20 (rank : 11)	NC score	0.711701 (rank : 7)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	105
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

BCR_HUMAN
θ value	5.99374e-20 (rank : 12)	NC score	0.647592 (rank : 32)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	81
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RHG25_MOUSE
θ value	2.5182e-18 (rank : 13)	NC score	0.656268 (rank : 30)
Query Neighborhood Hits	390	Target Neighborhood Hits	492	Shared Neighborhood Hits	133
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG05_MOUSE
θ value	3.28887e-18 (rank : 14)	NC score	0.667969 (rank : 24)
Query Neighborhood Hits	390	Target Neighborhood Hits	165	Shared Neighborhood Hits	88
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG12_HUMAN
θ value	5.60996e-18 (rank : 15)	NC score	0.710152 (rank : 8)
Query Neighborhood Hits	390	Target Neighborhood Hits	190	Shared Neighborhood Hits	101
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ABR_HUMAN
θ value	7.32683e-18 (rank : 16)	NC score	0.647221 (rank : 33)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	80
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG25_HUMAN
θ value	7.32683e-18 (rank : 17)	NC score	0.642288 (rank : 35)
Query Neighborhood Hits	390	Target Neighborhood Hits	550	Shared Neighborhood Hits	152
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OPHN1_HUMAN
θ value	2.7842e-17 (rank : 18)	NC score	0.662729 (rank : 26)
Query Neighborhood Hits	390	Target Neighborhood Hits	161	Shared Neighborhood Hits	82
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	3.63628e-17 (rank : 19)	NC score	0.659870 (rank : 27)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	84
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG01_HUMAN
θ value	3.07829e-16 (rank : 20)	NC score	0.680639 (rank : 18)
Query Neighborhood Hits	390	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG05_HUMAN
θ value	3.07829e-16 (rank : 21)	NC score	0.653801 (rank : 31)
Query Neighborhood Hits	390	Target Neighborhood Hits	158	Shared Neighborhood Hits	82
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

TCGAP_HUMAN
θ value	4.02038e-16 (rank : 22)	NC score	0.621832 (rank : 39)
Query Neighborhood Hits	390	Target Neighborhood Hits	872	Shared Neighborhood Hits	165
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	4.02038e-16 (rank : 23)	NC score	0.698897 (rank : 10)
Query Neighborhood Hits	390	Target Neighborhood Hits	409	Shared Neighborhood Hits	156
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP1_HUMAN
θ value	5.25075e-16 (rank : 24)	NC score	0.691157 (rank : 11)
Query Neighborhood Hits	390	Target Neighborhood Hits	376	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG08_HUMAN
θ value	5.25075e-16 (rank : 25)	NC score	0.667999 (rank : 23)
Query Neighborhood Hits	390	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

GMIP_MOUSE
θ value	1.16975e-15 (rank : 26)	NC score	0.691063 (rank : 12)
Query Neighborhood Hits	390	Target Neighborhood Hits	202	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_HUMAN
θ value	1.52774e-15 (rank : 27)	NC score	0.684420 (rank : 17)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG08_MOUSE
θ value	5.8054e-15 (rank : 28)	NC score	0.665941 (rank : 25)
Query Neighborhood Hits	390	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

3BP1_MOUSE
θ value	7.58209e-15 (rank : 29)	NC score	0.699357 (rank : 9)
Query Neighborhood Hits	390	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG09_HUMAN
θ value	2.20605e-14 (rank : 30)	NC score	0.727598 (rank : 6)
Query Neighborhood Hits	390	Target Neighborhood Hits	186	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RBP1_MOUSE
θ value	1.09485e-13 (rank : 31)	NC score	0.643381 (rank : 34)
Query Neighborhood Hits	390	Target Neighborhood Hits	493	Shared Neighborhood Hits	146
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG06_MOUSE
θ value	1.86753e-13 (rank : 32)	NC score	0.688093 (rank : 14)
Query Neighborhood Hits	390	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RBP1_HUMAN
θ value	3.18553e-13 (rank : 33)	NC score	0.627868 (rank : 38)
Query Neighborhood Hits	390	Target Neighborhood Hits	521	Shared Neighborhood Hits	148
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG06_HUMAN
θ value	3.18553e-13 (rank : 34)	NC score	0.688818 (rank : 13)
Query Neighborhood Hits	390	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CEND2_HUMAN
θ value	5.43371e-13 (rank : 35)	NC score	0.534674 (rank : 48)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

STA13_HUMAN
θ value	5.43371e-13 (rank : 36)	NC score	0.561773 (rank : 44)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

MYO9B_HUMAN
θ value	1.2105e-12 (rank : 37)	NC score	0.381384 (rank : 59)
Query Neighborhood Hits	390	Target Neighborhood Hits	641	Shared Neighborhood Hits	110
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CEND1_MOUSE
θ value	2.69671e-12 (rank : 38)	NC score	0.460482 (rank : 55)
Query Neighborhood Hits	390	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

RHG07_MOUSE
θ value	2.69671e-12 (rank : 39)	NC score	0.591168 (rank : 42)
Query Neighborhood Hits	390	Target Neighborhood Hits	103	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

MYO9B_MOUSE
θ value	4.59992e-12 (rank : 40)	NC score	0.386504 (rank : 57)
Query Neighborhood Hits	390	Target Neighborhood Hits	311	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

STA13_MOUSE
θ value	7.84624e-12 (rank : 41)	NC score	0.552167 (rank : 45)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

RHG26_HUMAN
θ value	2.98157e-11 (rank : 42)	NC score	0.670984 (rank : 22)
Query Neighborhood Hits	390	Target Neighborhood Hits	281	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

TAGAP_HUMAN
θ value	8.67504e-11 (rank : 43)	NC score	0.635336 (rank : 36)
Query Neighborhood Hits	390	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RGAP1_MOUSE
θ value	1.133e-10 (rank : 44)	NC score	0.658841 (rank : 28)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG07_HUMAN
θ value	1.133e-10 (rank : 45)	NC score	0.581351 (rank : 43)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	65
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CEND1_HUMAN
θ value	1.47974e-10 (rank : 46)	NC score	0.440696 (rank : 56)
Query Neighborhood Hits	390	Target Neighborhood Hits	284	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RGAP1_HUMAN
θ value	2.52405e-10 (rank : 47)	NC score	0.657779 (rank : 29)
Query Neighborhood Hits	390	Target Neighborhood Hits	189	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

TAGAP_MOUSE
θ value	1.25267e-09 (rank : 48)	NC score	0.633659 (rank : 37)
Query Neighborhood Hits	390	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

STAR8_MOUSE
θ value	1.63604e-09 (rank : 49)	NC score	0.549651 (rank : 46)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
θ value	2.13673e-09 (rank : 50)	NC score	0.542021 (rank : 47)
Query Neighborhood Hits	390	Target Neighborhood Hits	216	Shared Neighborhood Hits	63
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CEND3_MOUSE
θ value	8.11959e-09 (rank : 51)	NC score	0.490862 (rank : 52)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CIP4_HUMAN
θ value	1.06045e-08 (rank : 52)	NC score	0.299925 (rank : 82)
Query Neighborhood Hits	390	Target Neighborhood Hits	374	Shared Neighborhood Hits	141
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CEND3_HUMAN
θ value	4.0297e-08 (rank : 53)	NC score	0.481066 (rank : 53)
Query Neighborhood Hits	390	Target Neighborhood Hits	275	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

K1688_MOUSE
θ value	7.59969e-07 (rank : 54)	NC score	0.492864 (rank : 51)
Query Neighborhood Hits	390	Target Neighborhood Hits	188	Shared Neighborhood Hits	69
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
θ value	9.92553e-07 (rank : 55)	NC score	0.478420 (rank : 54)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	71
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CE005_MOUSE
θ value	1.29631e-06 (rank : 56)	NC score	0.530706 (rank : 50)
Query Neighborhood Hits	390	Target Neighborhood Hits	238	Shared Neighborhood Hits	99
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

ITSN1_HUMAN
θ value	1.29631e-06 (rank : 57)	NC score	0.256093 (rank : 101)
Query Neighborhood Hits	390	Target Neighborhood Hits	1757	Shared Neighborhood Hits	284
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
θ value	1.29631e-06 (rank : 58)	NC score	0.264237 (rank : 97)
Query Neighborhood Hits	390	Target Neighborhood Hits	1371	Shared Neighborhood Hits	275
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CE005_HUMAN
θ value	1.69304e-06 (rank : 59)	NC score	0.531022 (rank : 49)
Query Neighborhood Hits	390	Target Neighborhood Hits	213	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

ITSN2_HUMAN
θ value	2.88788e-06 (rank : 60)	NC score	0.266984 (rank : 94)
Query Neighborhood Hits	390	Target Neighborhood Hits	1173	Shared Neighborhood Hits	262
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

RHG18_HUMAN
θ value	3.77169e-06 (rank : 61)	NC score	0.610653 (rank : 40)
Query Neighborhood Hits	390	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

NCF4_MOUSE
θ value	8.40245e-06 (rank : 62)	NC score	0.332736 (rank : 61)
Query Neighborhood Hits	390	Target Neighborhood Hits	177	Shared Neighborhood Hits	118
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ANM2_MOUSE
θ value	1.09739e-05 (rank : 63)	NC score	0.216782 (rank : 138)
Query Neighborhood Hits	390	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CCD46_HUMAN
θ value	1.09739e-05 (rank : 64)	NC score	0.124417 (rank : 185)
Query Neighborhood Hits	390	Target Neighborhood Hits	1430	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

NCK2_HUMAN
θ value	1.43324e-05 (rank : 65)	NC score	0.330834 (rank : 63)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RHG18_MOUSE
θ value	2.44474e-05 (rank : 66)	NC score	0.600771 (rank : 41)
Query Neighborhood Hits	390	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

SRBS1_HUMAN
θ value	2.44474e-05 (rank : 67)	NC score	0.327533 (rank : 64)
Query Neighborhood Hits	390	Target Neighborhood Hits	396	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NPHP1_MOUSE
θ value	3.19293e-05 (rank : 68)	NC score	0.317161 (rank : 68)
Query Neighborhood Hits	390	Target Neighborhood Hits	267	Shared Neighborhood Hits	162
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ITSN1_MOUSE
θ value	4.1701e-05 (rank : 69)	NC score	0.251089 (rank : 105)
Query Neighborhood Hits	390	Target Neighborhood Hits	1669	Shared Neighborhood Hits	279
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SRBS1_MOUSE
θ value	4.1701e-05 (rank : 70)	NC score	0.323901 (rank : 67)
Query Neighborhood Hits	390	Target Neighborhood Hits	409	Shared Neighborhood Hits	152
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

YES_MOUSE
θ value	4.1701e-05 (rank : 71)	NC score	0.112130 (rank : 202)
Query Neighborhood Hits	390	Target Neighborhood Hits	1052	Shared Neighborhood Hits	169
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

NPHP1_HUMAN
θ value	5.44631e-05 (rank : 72)	NC score	0.295714 (rank : 85)
Query Neighborhood Hits	390	Target Neighborhood Hits	288	Shared Neighborhood Hits	153
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SPTA2_HUMAN
θ value	5.44631e-05 (rank : 73)	NC score	0.196790 (rank : 145)
Query Neighborhood Hits	390	Target Neighborhood Hits	888	Shared Neighborhood Hits	245
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

VINEX_MOUSE
θ value	5.44631e-05 (rank : 74)	NC score	0.331675 (rank : 62)
Query Neighborhood Hits	390	Target Neighborhood Hits	286	Shared Neighborhood Hits	151
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABI2_MOUSE
θ value	7.1131e-05 (rank : 75)	NC score	0.306559 (rank : 76)
Query Neighborhood Hits	390	Target Neighborhood Hits	266	Shared Neighborhood Hits	143
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
θ value	9.29e-05 (rank : 76)	NC score	0.303518 (rank : 78)
Query Neighborhood Hits	390	Target Neighborhood Hits	350	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GRB2_HUMAN
θ value	9.29e-05 (rank : 77)	NC score	0.316039 (rank : 69)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	9.29e-05 (rank : 78)	NC score	0.315726 (rank : 70)
Query Neighborhood Hits	390	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

LIPA1_HUMAN
θ value	9.29e-05 (rank : 79)	NC score	0.111999 (rank : 203)
Query Neighborhood Hits	390	Target Neighborhood Hits	1294	Shared Neighborhood Hits	162
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

YES_HUMAN
θ value	9.29e-05 (rank : 80)	NC score	0.110374 (rank : 208)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	169
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CRKL_HUMAN
θ value	0.000121331 (rank : 81)	NC score	0.293858 (rank : 86)
Query Neighborhood Hits	390	Target Neighborhood Hits	313	Shared Neighborhood Hits	153
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

FER_HUMAN
θ value	0.000121331 (rank : 82)	NC score	0.082043 (rank : 371)
Query Neighborhood Hits	390	Target Neighborhood Hits	1278	Shared Neighborhood Hits	169
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

I5P2_HUMAN
θ value	0.000121331 (rank : 83)	NC score	0.326870 (rank : 66)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

NCF4_HUMAN
θ value	0.000121331 (rank : 84)	NC score	0.314072 (rank : 71)
Query Neighborhood Hits	390	Target Neighborhood Hits	161	Shared Neighborhood Hits	110
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	0.000121331 (rank : 85)	NC score	0.310672 (rank : 73)
Query Neighborhood Hits	390	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH3K1_MOUSE
θ value	0.000121331 (rank : 86)	NC score	0.311762 (rank : 72)
Query Neighborhood Hits	390	Target Neighborhood Hits	332	Shared Neighborhood Hits	159
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

OCRL_HUMAN
θ value	0.00020696 (rank : 87)	NC score	0.306736 (rank : 75)
Query Neighborhood Hits	390	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

VINEX_HUMAN
θ value	0.00020696 (rank : 88)	NC score	0.327107 (rank : 65)
Query Neighborhood Hits	390	Target Neighborhood Hits	270	Shared Neighborhood Hits	147
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ANM2_HUMAN
θ value	0.000270298 (rank : 89)	NC score	0.216680 (rank : 139)
Query Neighborhood Hits	390	Target Neighborhood Hits	175	Shared Neighborhood Hits	129
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CRKL_MOUSE
θ value	0.00035302 (rank : 90)	NC score	0.282385 (rank : 87)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

P85A_MOUSE
θ value	0.00035302 (rank : 91)	NC score	0.385334 (rank : 58)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	184
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CCD46_MOUSE
θ value	0.000461057 (rank : 92)	NC score	0.116946 (rank : 188)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	171
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

VAV3_MOUSE
θ value	0.000602161 (rank : 93)	NC score	0.245185 (rank : 108)
Query Neighborhood Hits	390	Target Neighborhood Hits	404	Shared Neighborhood Hits	151
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

HCLS1_MOUSE
θ value	0.000786445 (rank : 94)	NC score	0.299228 (rank : 83)
Query Neighborhood Hits	390	Target Neighborhood Hits	329	Shared Neighborhood Hits	143
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

VAV2_HUMAN
θ value	0.000786445 (rank : 95)	NC score	0.244414 (rank : 109)
Query Neighborhood Hits	390	Target Neighborhood Hits	453	Shared Neighborhood Hits	149
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.000786445 (rank : 96)	NC score	0.243789 (rank : 111)
Query Neighborhood Hits	390	Target Neighborhood Hits	456	Shared Neighborhood Hits	149
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	0.000786445 (rank : 97)	NC score	0.248298 (rank : 107)
Query Neighborhood Hits	390	Target Neighborhood Hits	398	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

LIPA2_MOUSE
θ value	0.00102713 (rank : 98)	NC score	0.108710 (rank : 211)
Query Neighborhood Hits	390	Target Neighborhood Hits	1282	Shared Neighborhood Hits	160
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

SH3K1_HUMAN
θ value	0.00102713 (rank : 99)	NC score	0.300143 (rank : 81)
Query Neighborhood Hits	390	Target Neighborhood Hits	341	Shared Neighborhood Hits	159
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

HCLS1_HUMAN
θ value	0.00134147 (rank : 100)	NC score	0.300606 (rank : 79)
Query Neighborhood Hits	390	Target Neighborhood Hits	358	Shared Neighborhood Hits	146
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

FYN_HUMAN
θ value	0.00175202 (rank : 101)	NC score	0.105280 (rank : 223)
Query Neighborhood Hits	390	Target Neighborhood Hits	1078	Shared Neighborhood Hits	165
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00175202 (rank : 102)	NC score	0.107515 (rank : 214)
Query Neighborhood Hits	390	Target Neighborhood Hits	1073	Shared Neighborhood Hits	164
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
θ value	0.00175202 (rank : 103)	NC score	0.105855 (rank : 218)
Query Neighborhood Hits	390	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ARHG7_MOUSE
θ value	0.00228821 (rank : 104)	NC score	0.265079 (rank : 96)
Query Neighborhood Hits	390	Target Neighborhood Hits	396	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MYO1F_MOUSE
θ value	0.00228821 (rank : 105)	NC score	0.169445 (rank : 156)
Query Neighborhood Hits	390	Target Neighborhood Hits	262	Shared Neighborhood Hits	157
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

FGR_HUMAN
θ value	0.00298849 (rank : 106)	NC score	0.109295 (rank : 210)
Query Neighborhood Hits	390	Target Neighborhood Hits	1067	Shared Neighborhood Hits	163
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	0.00298849 (rank : 107)	NC score	0.106805 (rank : 215)
Query Neighborhood Hits	390	Target Neighborhood Hits	1069	Shared Neighborhood Hits	165
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

IASPP_HUMAN
θ value	0.00298849 (rank : 108)	NC score	0.175223 (rank : 153)
Query Neighborhood Hits	390	Target Neighborhood Hits	688	Shared Neighborhood Hits	139
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

P85A_HUMAN
θ value	0.00298849 (rank : 109)	NC score	0.379861 (rank : 60)
Query Neighborhood Hits	390	Target Neighborhood Hits	479	Shared Neighborhood Hits	194
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPTA1_HUMAN
θ value	0.00298849 (rank : 110)	NC score	0.179742 (rank : 149)
Query Neighborhood Hits	390	Target Neighborhood Hits	748	Shared Neighborhood Hits	236
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ABI1_MOUSE
θ value	0.00390308 (rank : 111)	NC score	0.281012 (rank : 88)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	139
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

COFA1_MOUSE
θ value	0.00390308 (rank : 112)	NC score	0.023699 (rank : 861)
Query Neighborhood Hits	390	Target Neighborhood Hits	305	Shared Neighborhood Hits	9
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

MOES_HUMAN
θ value	0.00390308 (rank : 113)	NC score	0.083322 (rank : 353)
Query Neighborhood Hits	390	Target Neighborhood Hits	892	Shared Neighborhood Hits	125
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

SPTA1_MOUSE
θ value	0.00390308 (rank : 114)	NC score	0.176256 (rank : 151)
Query Neighborhood Hits	390	Target Neighborhood Hits	675	Shared Neighborhood Hits	218
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

AAK1_MOUSE
θ value	0.00509761 (rank : 115)	NC score	0.022274 (rank : 863)
Query Neighborhood Hits	390	Target Neighborhood Hits	1051	Shared Neighborhood Hits	52
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

MYO1F_HUMAN
θ value	0.00509761 (rank : 116)	NC score	0.168364 (rank : 157)
Query Neighborhood Hits	390	Target Neighborhood Hits	275	Shared Neighborhood Hits	157
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

GRAP_HUMAN
θ value	0.00665767 (rank : 117)	NC score	0.307718 (rank : 74)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	155
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

RADI_HUMAN
θ value	0.00665767 (rank : 118)	NC score	0.078003 (rank : 431)
Query Neighborhood Hits	390	Target Neighborhood Hits	741	Shared Neighborhood Hits	119
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

BTK_MOUSE
θ value	0.00869519 (rank : 119)	NC score	0.092588 (rank : 277)
Query Neighborhood Hits	390	Target Neighborhood Hits	1017	Shared Neighborhood Hits	155
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FRK_HUMAN
θ value	0.00869519 (rank : 120)	NC score	0.086330 (rank : 326)
Query Neighborhood Hits	390	Target Neighborhood Hits	1058	Shared Neighborhood Hits	162
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MOES_MOUSE
θ value	0.00869519 (rank : 121)	NC score	0.082377 (rank : 363)
Query Neighborhood Hits	390	Target Neighborhood Hits	923	Shared Neighborhood Hits	125
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

RAI14_HUMAN
θ value	0.00869519 (rank : 122)	NC score	0.065598 (rank : 624)
Query Neighborhood Hits	390	Target Neighborhood Hits	1367	Shared Neighborhood Hits	149
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

TXK_MOUSE
θ value	0.00869519 (rank : 123)	NC score	0.081056 (rank : 386)
Query Neighborhood Hits	390	Target Neighborhood Hits	980	Shared Neighborhood Hits	128
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ARHG9_HUMAN
θ value	0.0113563 (rank : 124)	NC score	0.201769 (rank : 143)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	132
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.0113563 (rank : 125)	NC score	0.202955 (rank : 142)
Query Neighborhood Hits	390	Target Neighborhood Hits	234	Shared Neighborhood Hits	133
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

IASPP_MOUSE
θ value	0.0113563 (rank : 126)	NC score	0.159369 (rank : 166)
Query Neighborhood Hits	390	Target Neighborhood Hits	1024	Shared Neighborhood Hits	149
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MY18A_HUMAN
θ value	0.0113563 (rank : 127)	NC score	0.114439 (rank : 193)
Query Neighborhood Hits	390	Target Neighborhood Hits	1929	Shared Neighborhood Hits	193
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RADI_MOUSE
θ value	0.0113563 (rank : 128)	NC score	0.077677 (rank : 437)
Query Neighborhood Hits	390	Target Neighborhood Hits	773	Shared Neighborhood Hits	116
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

ABI1_HUMAN
θ value	0.0148317 (rank : 129)	NC score	0.265687 (rank : 95)
Query Neighborhood Hits	390	Target Neighborhood Hits	257	Shared Neighborhood Hits	141
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

BTK_HUMAN
θ value	0.0148317 (rank : 130)	NC score	0.094257 (rank : 268)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	161
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CRK_HUMAN
θ value	0.0148317 (rank : 131)	NC score	0.268766 (rank : 91)
Query Neighborhood Hits	390	Target Neighborhood Hits	308	Shared Neighborhood Hits	147
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0148317 (rank : 132)	NC score	0.268519 (rank : 92)
Query Neighborhood Hits	390	Target Neighborhood Hits	314	Shared Neighborhood Hits	147
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PACN2_HUMAN
θ value	0.0148317 (rank : 133)	NC score	0.242910 (rank : 112)
Query Neighborhood Hits	390	Target Neighborhood Hits	339	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

EZRI_MOUSE
θ value	0.0193708 (rank : 134)	NC score	0.076747 (rank : 448)
Query Neighborhood Hits	390	Target Neighborhood Hits	693	Shared Neighborhood Hits	112
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

REST_MOUSE
θ value	0.0193708 (rank : 135)	NC score	0.097137 (rank : 254)
Query Neighborhood Hits	390	Target Neighborhood Hits	1506	Shared Neighborhood Hits	163
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

GOGA4_MOUSE
θ value	0.0252991 (rank : 136)	NC score	0.096425 (rank : 259)
Query Neighborhood Hits	390	Target Neighborhood Hits	1939	Shared Neighborhood Hits	183
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

LETM1_HUMAN
θ value	0.0252991 (rank : 137)	NC score	0.080099 (rank : 397)
Query Neighborhood Hits	390	Target Neighborhood Hits	338	Shared Neighborhood Hits	81
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

AHI1_MOUSE
θ value	0.0330416 (rank : 138)	NC score	0.195530 (rank : 146)
Query Neighborhood Hits	390	Target Neighborhood Hits	496	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CD2AP_HUMAN
θ value	0.0330416 (rank : 139)	NC score	0.298865 (rank : 84)
Query Neighborhood Hits	390	Target Neighborhood Hits	315	Shared Neighborhood Hits	166
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP_MOUSE
θ value	0.0330416 (rank : 140)	NC score	0.300261 (rank : 80)
Query Neighborhood Hits	390	Target Neighborhood Hits	309	Shared Neighborhood Hits	155
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NAF1_MOUSE
θ value	0.0330416 (rank : 141)	NC score	0.097816 (rank : 252)
Query Neighborhood Hits	390	Target Neighborhood Hits	852	Shared Neighborhood Hits	132
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

STAM2_HUMAN
θ value	0.0330416 (rank : 142)	NC score	0.234589 (rank : 120)
Query Neighborhood Hits	390	Target Neighborhood Hits	288	Shared Neighborhood Hits	150
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG7_HUMAN
θ value	0.0431538 (rank : 143)	NC score	0.241460 (rank : 114)
Query Neighborhood Hits	390	Target Neighborhood Hits	347	Shared Neighborhood Hits	156
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

BLK_MOUSE
θ value	0.0431538 (rank : 144)	NC score	0.077906 (rank : 435)
Query Neighborhood Hits	390	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CN094_HUMAN
θ value	0.0431538 (rank : 145)	NC score	0.046530 (rank : 832)
Query Neighborhood Hits	390	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

FYV1_HUMAN
θ value	0.0431538 (rank : 146)	NC score	0.051043 (rank : 807)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

GRAP2_HUMAN
θ value	0.0431538 (rank : 147)	NC score	0.270493 (rank : 90)
Query Neighborhood Hits	390	Target Neighborhood Hits	304	Shared Neighborhood Hits	152
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3G2_HUMAN
θ value	0.0431538 (rank : 148)	NC score	0.250226 (rank : 106)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SMC4_HUMAN
θ value	0.0431538 (rank : 149)	NC score	0.085193 (rank : 338)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

AAK1_HUMAN
θ value	0.0563607 (rank : 150)	NC score	0.023243 (rank : 862)
Query Neighborhood Hits	390	Target Neighborhood Hits	1077	Shared Neighborhood Hits	59
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

FYV1_MOUSE
θ value	0.0563607 (rank : 151)	NC score	0.054574 (rank : 752)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

OSTF1_HUMAN
θ value	0.0563607 (rank : 152)	NC score	0.224469 (rank : 131)
Query Neighborhood Hits	390	Target Neighborhood Hits	466	Shared Neighborhood Hits	151
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH3G3_HUMAN
θ value	0.0563607 (rank : 153)	NC score	0.234839 (rank : 119)
Query Neighborhood Hits	390	Target Neighborhood Hits	222	Shared Neighborhood Hits	141
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TNIP3_HUMAN
θ value	0.0563607 (rank : 154)	NC score	0.103826 (rank : 229)
Query Neighborhood Hits	390	Target Neighborhood Hits	511	Shared Neighborhood Hits	110
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

GFAP_MOUSE
θ value	0.0736092 (rank : 155)	NC score	0.047732 (rank : 830)
Query Neighborhood Hits	390	Target Neighborhood Hits	725	Shared Neighborhood Hits	132
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

HCK_HUMAN
θ value	0.0736092 (rank : 156)	NC score	0.086225 (rank : 328)
Query Neighborhood Hits	390	Target Neighborhood Hits	1035	Shared Neighborhood Hits	153
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MYH4_HUMAN
θ value	0.0736092 (rank : 157)	NC score	0.106134 (rank : 217)
Query Neighborhood Hits	390	Target Neighborhood Hits	1377	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

NCF2_HUMAN
θ value	0.0736092 (rank : 158)	NC score	0.304562 (rank : 77)
Query Neighborhood Hits	390	Target Neighborhood Hits	229	Shared Neighborhood Hits	132
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

RFIP3_HUMAN
θ value	0.0736092 (rank : 159)	NC score	0.094676 (rank : 266)
Query Neighborhood Hits	390	Target Neighborhood Hits	1055	Shared Neighborhood Hits	137
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

SH3G3_MOUSE
θ value	0.0736092 (rank : 160)	NC score	0.238178 (rank : 116)
Query Neighborhood Hits	390	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

AHI1_HUMAN
θ value	0.0961366 (rank : 161)	NC score	0.194679 (rank : 148)
Query Neighborhood Hits	390	Target Neighborhood Hits	537	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

PACN1_MOUSE
θ value	0.0961366 (rank : 162)	NC score	0.225612 (rank : 130)
Query Neighborhood Hits	390	Target Neighborhood Hits	283	Shared Neighborhood Hits	156
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ROCK2_MOUSE
θ value	0.0961366 (rank : 163)	NC score	0.057374 (rank : 717)
Query Neighborhood Hits	390	Target Neighborhood Hits	2072	Shared Neighborhood Hits	192
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SH3G1_MOUSE
θ value	0.0961366 (rank : 164)	NC score	0.239712 (rank : 115)
Query Neighborhood Hits	390	Target Neighborhood Hits	291	Shared Neighborhood Hits	163
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
θ value	0.0961366 (rank : 165)	NC score	0.241507 (rank : 113)
Query Neighborhood Hits	390	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SRC_MOUSE
θ value	0.0961366 (rank : 166)	NC score	0.088511 (rank : 305)
Query Neighborhood Hits	390	Target Neighborhood Hits	1033	Shared Neighborhood Hits	154
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

TXK_HUMAN
θ value	0.0961366 (rank : 167)	NC score	0.075607 (rank : 461)
Query Neighborhood Hits	390	Target Neighborhood Hits	971	Shared Neighborhood Hits	120
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CR034_HUMAN
θ value	0.125558 (rank : 168)	NC score	0.096842 (rank : 257)
Query Neighborhood Hits	390	Target Neighborhood Hits	538	Shared Neighborhood Hits	109
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

EPS8_MOUSE
θ value	0.125558 (rank : 169)	NC score	0.101257 (rank : 239)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ITK_HUMAN
θ value	0.125558 (rank : 170)	NC score	0.073876 (rank : 495)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	128
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MYH9_MOUSE
θ value	0.125558 (rank : 171)	NC score	0.105448 (rank : 221)
Query Neighborhood Hits	390	Target Neighborhood Hits	1829	Shared Neighborhood Hits	179
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

OSTF1_MOUSE
θ value	0.125558 (rank : 172)	NC score	0.215085 (rank : 141)
Query Neighborhood Hits	390	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	0.125558 (rank : 173)	NC score	0.225988 (rank : 128)
Query Neighborhood Hits	390	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
θ value	0.125558 (rank : 174)	NC score	0.233024 (rank : 122)
Query Neighborhood Hits	390	Target Neighborhood Hits	382	Shared Neighborhood Hits	178
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SEP11_MOUSE
θ value	0.125558 (rank : 175)	NC score	0.035238 (rank : 844)
Query Neighborhood Hits	390	Target Neighborhood Hits	300	Shared Neighborhood Hits	71
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

SPFH1_HUMAN
θ value	0.125558 (rank : 176)	NC score	0.037529 (rank : 838)
Query Neighborhood Hits	390	Target Neighborhood Hits	91	Shared Neighborhood Hits	13
SwissProt Accessions	O75477	Gene names	SPFH1, C10orf69, KE04, KEO4
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 1 precursor (Protein KE04).

SRC8_MOUSE
θ value	0.125558 (rank : 177)	NC score	0.259017 (rank : 99)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	150
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC_MOUSE
θ value	0.125558 (rank : 178)	NC score	0.255127 (rank : 102)
Query Neighborhood Hits	390	Target Neighborhood Hits	268	Shared Neighborhood Hits	141
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TEC_HUMAN
θ value	0.125558 (rank : 179)	NC score	0.076019 (rank : 457)
Query Neighborhood Hits	390	Target Neighborhood Hits	1006	Shared Neighborhood Hits	133
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHG4_HUMAN
θ value	0.163984 (rank : 180)	NC score	0.195412 (rank : 147)
Query Neighborhood Hits	390	Target Neighborhood Hits	242	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ASPP2_HUMAN
θ value	0.163984 (rank : 181)	NC score	0.145923 (rank : 175)
Query Neighborhood Hits	390	Target Neighborhood Hits	1156	Shared Neighborhood Hits	227
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

CENPF_HUMAN
θ value	0.163984 (rank : 182)	NC score	0.102781 (rank : 234)
Query Neighborhood Hits	390	Target Neighborhood Hits	1932	Shared Neighborhood Hits	187
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CP250_HUMAN
θ value	0.163984 (rank : 183)	NC score	0.093936 (rank : 269)
Query Neighborhood Hits	390	Target Neighborhood Hits	1805	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

GOGA3_MOUSE
θ value	0.163984 (rank : 184)	NC score	0.097135 (rank : 255)
Query Neighborhood Hits	390	Target Neighborhood Hits	1437	Shared Neighborhood Hits	159
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA6_HUMAN
θ value	0.163984 (rank : 185)	NC score	0.094894 (rank : 263)
Query Neighborhood Hits	390	Target Neighborhood Hits	1007	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GRAP2_MOUSE
θ value	0.163984 (rank : 186)	NC score	0.267267 (rank : 93)
Query Neighborhood Hits	390	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MYH1_HUMAN
θ value	0.163984 (rank : 187)	NC score	0.106770 (rank : 216)
Query Neighborhood Hits	390	Target Neighborhood Hits	1478	Shared Neighborhood Hits	173
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH8_HUMAN
θ value	0.163984 (rank : 188)	NC score	0.112808 (rank : 197)
Query Neighborhood Hits	390	Target Neighborhood Hits	1610	Shared Neighborhood Hits	182
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	0.163984 (rank : 189)	NC score	0.111145 (rank : 206)
Query Neighborhood Hits	390	Target Neighborhood Hits	1600	Shared Neighborhood Hits	178
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SPFH1_MOUSE
θ value	0.163984 (rank : 190)	NC score	0.037094 (rank : 839)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q91X78, Q8CIH7	Gene names	Spfh1, Keo4
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 1 precursor (KE04 protein homolog).

STAC_HUMAN
θ value	0.163984 (rank : 191)	NC score	0.257581 (rank : 100)
Query Neighborhood Hits	390	Target Neighborhood Hits	276	Shared Neighborhood Hits	142
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV_MOUSE
θ value	0.163984 (rank : 192)	NC score	0.228061 (rank : 125)
Query Neighborhood Hits	390	Target Neighborhood Hits	430	Shared Neighborhood Hits	148
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CENPE_HUMAN
θ value	0.21417 (rank : 193)	NC score	0.084811 (rank : 341)
Query Neighborhood Hits	390	Target Neighborhood Hits	2060	Shared Neighborhood Hits	192
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CI039_HUMAN
θ value	0.21417 (rank : 194)	NC score	0.093212 (rank : 272)
Query Neighborhood Hits	390	Target Neighborhood Hits	1171	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

DLG5_HUMAN
θ value	0.21417 (rank : 195)	NC score	0.100660 (rank : 240)
Query Neighborhood Hits	390	Target Neighborhood Hits	1088	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DYDC1_HUMAN
θ value	0.21417 (rank : 196)	NC score	0.049354 (rank : 829)
Query Neighborhood Hits	390	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WWB3, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87	Gene names	DYDC1, DPY30D1
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 1 (RSD-9).

LETM1_MOUSE
θ value	0.21417 (rank : 197)	NC score	0.065179 (rank : 629)
Query Neighborhood Hits	390	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

MYH1_MOUSE
θ value	0.21417 (rank : 198)	NC score	0.108339 (rank : 213)
Query Neighborhood Hits	390	Target Neighborhood Hits	1461	Shared Neighborhood Hits	180
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_MOUSE
θ value	0.21417 (rank : 199)	NC score	0.103608 (rank : 232)
Query Neighborhood Hits	390	Target Neighborhood Hits	1476	Shared Neighborhood Hits	177
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

NAF1_HUMAN
θ value	0.21417 (rank : 200)	NC score	0.096276 (rank : 260)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	139
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

PACN3_HUMAN
θ value	0.21417 (rank : 201)	NC score	0.218398 (rank : 137)
Query Neighborhood Hits	390	Target Neighborhood Hits	385	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.21417 (rank : 202)	NC score	0.220487 (rank : 135)
Query Neighborhood Hits	390	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PPIP1_MOUSE
θ value	0.21417 (rank : 203)	NC score	0.254922 (rank : 103)
Query Neighborhood Hits	390	Target Neighborhood Hits	377	Shared Neighborhood Hits	195
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G1_HUMAN
θ value	0.21417 (rank : 204)	NC score	0.236905 (rank : 117)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SNX13_MOUSE
θ value	0.21417 (rank : 205)	NC score	0.024767 (rank : 857)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

SYCP1_MOUSE
θ value	0.21417 (rank : 206)	NC score	0.092275 (rank : 285)
Query Neighborhood Hits	390	Target Neighborhood Hits	1456	Shared Neighborhood Hits	165
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

VAV_HUMAN
θ value	0.21417 (rank : 207)	NC score	0.225786 (rank : 129)
Query Neighborhood Hits	390	Target Neighborhood Hits	452	Shared Neighborhood Hits	153
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ASPP1_HUMAN
θ value	0.279714 (rank : 208)	NC score	0.156975 (rank : 168)
Query Neighborhood Hits	390	Target Neighborhood Hits	956	Shared Neighborhood Hits	210
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CASL_HUMAN
θ value	0.279714 (rank : 209)	NC score	0.143041 (rank : 180)
Query Neighborhood Hits	390	Target Neighborhood Hits	259	Shared Neighborhood Hits	129
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DNMBP_HUMAN
θ value	0.279714 (rank : 210)	NC score	0.244298 (rank : 110)
Query Neighborhood Hits	390	Target Neighborhood Hits	413	Shared Neighborhood Hits	173
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DVL3_HUMAN
θ value	0.279714 (rank : 211)	NC score	0.018427 (rank : 868)
Query Neighborhood Hits	390	Target Neighborhood Hits	194	Shared Neighborhood Hits	14
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

KIF2C_HUMAN
θ value	0.279714 (rank : 212)	NC score	0.017850 (rank : 872)
Query Neighborhood Hits	390	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

KTN1_HUMAN
θ value	0.279714 (rank : 213)	NC score	0.087008 (rank : 321)
Query Neighborhood Hits	390	Target Neighborhood Hits	1197	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MPP6_HUMAN
θ value	0.279714 (rank : 214)	NC score	0.076398 (rank : 453)
Query Neighborhood Hits	390	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	0.279714 (rank : 215)	NC score	0.075447 (rank : 465)
Query Neighborhood Hits	390	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MYH6_MOUSE
θ value	0.279714 (rank : 216)	NC score	0.103235 (rank : 233)
Query Neighborhood Hits	390	Target Neighborhood Hits	1501	Shared Neighborhood Hits	169
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

STAM1_MOUSE
θ value	0.279714 (rank : 217)	NC score	0.233806 (rank : 121)
Query Neighborhood Hits	390	Target Neighborhood Hits	273	Shared Neighborhood Hits	145
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

TEC_MOUSE
θ value	0.279714 (rank : 218)	NC score	0.075689 (rank : 459)
Query Neighborhood Hits	390	Target Neighborhood Hits	1006	Shared Neighborhood Hits	134
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TENS1_HUMAN
θ value	0.279714 (rank : 219)	NC score	0.042804 (rank : 833)
Query Neighborhood Hits	390	Target Neighborhood Hits	400	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ARHG6_MOUSE
θ value	0.365318 (rank : 220)	NC score	0.227162 (rank : 126)
Query Neighborhood Hits	390	Target Neighborhood Hits	394	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DEN2A_HUMAN
θ value	0.365318 (rank : 221)	NC score	0.013404 (rank : 882)
Query Neighborhood Hits	390	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

DNMBP_MOUSE
θ value	0.365318 (rank : 222)	NC score	0.230006 (rank : 124)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	162
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MRCKA_HUMAN
θ value	0.365318 (rank : 223)	NC score	0.063524 (rank : 650)
Query Neighborhood Hits	390	Target Neighborhood Hits	1999	Shared Neighborhood Hits	199
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

STAM1_HUMAN
θ value	0.365318 (rank : 224)	NC score	0.232636 (rank : 123)
Query Neighborhood Hits	390	Target Neighborhood Hits	271	Shared Neighborhood Hits	147
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG6_HUMAN
θ value	0.47712 (rank : 225)	NC score	0.220457 (rank : 136)
Query Neighborhood Hits	390	Target Neighborhood Hits	376	Shared Neighborhood Hits	170
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

GOGA5_MOUSE
θ value	0.47712 (rank : 226)	NC score	0.100383 (rank : 242)
Query Neighborhood Hits	390	Target Neighborhood Hits	1434	Shared Neighborhood Hits	164
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

HCK_MOUSE
θ value	0.47712 (rank : 227)	NC score	0.083242 (rank : 354)
Query Neighborhood Hits	390	Target Neighborhood Hits	1029	Shared Neighborhood Hits	151
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

K1967_MOUSE
θ value	0.47712 (rank : 228)	NC score	0.032239 (rank : 847)
Query Neighborhood Hits	390	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

LIPA2_HUMAN
θ value	0.47712 (rank : 229)	NC score	0.096566 (rank : 258)
Query Neighborhood Hits	390	Target Neighborhood Hits	1044	Shared Neighborhood Hits	145
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

NEBU_HUMAN
θ value	0.47712 (rank : 230)	NC score	0.161558 (rank : 164)
Query Neighborhood Hits	390	Target Neighborhood Hits	420	Shared Neighborhood Hits	161
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SRC8_HUMAN
θ value	0.47712 (rank : 231)	NC score	0.251869 (rank : 104)
Query Neighborhood Hits	390	Target Neighborhood Hits	269	Shared Neighborhood Hits	149
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

TXLNA_MOUSE
θ value	0.47712 (rank : 232)	NC score	0.077342 (rank : 444)
Query Neighborhood Hits	390	Target Neighborhood Hits	846	Shared Neighborhood Hits	126
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

C8AP2_MOUSE
θ value	0.62314 (rank : 233)	NC score	0.036220 (rank : 842)
Query Neighborhood Hits	390	Target Neighborhood Hits	405	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CUTL2_HUMAN
θ value	0.62314 (rank : 234)	NC score	0.053292 (rank : 764)
Query Neighborhood Hits	390	Target Neighborhood Hits	906	Shared Neighborhood Hits	110
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

GOGA5_HUMAN
θ value	0.62314 (rank : 235)	NC score	0.092450 (rank : 280)
Query Neighborhood Hits	390	Target Neighborhood Hits	1168	Shared Neighborhood Hits	149
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

IFT81_HUMAN
θ value	0.62314 (rank : 236)	NC score	0.086567 (rank : 325)
Query Neighborhood Hits	390	Target Neighborhood Hits	893	Shared Neighborhood Hits	142
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

MAML1_HUMAN
θ value	0.62314 (rank : 237)	NC score	0.018733 (rank : 867)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MY18A_MOUSE
θ value	0.62314 (rank : 238)	NC score	0.109315 (rank : 209)
Query Neighborhood Hits	390	Target Neighborhood Hits	1989	Shared Neighborhood Hits	193
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH10_MOUSE
θ value	0.62314 (rank : 239)	NC score	0.105643 (rank : 219)
Query Neighborhood Hits	390	Target Neighborhood Hits	1612	Shared Neighborhood Hits	175
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PPIP1_HUMAN
θ value	0.62314 (rank : 240)	NC score	0.260418 (rank : 98)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	199
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RUSC1_MOUSE
θ value	0.62314 (rank : 241)	NC score	0.168248 (rank : 158)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

STAM2_MOUSE
θ value	0.62314 (rank : 242)	NC score	0.236619 (rank : 118)
Query Neighborhood Hits	390	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CEP63_HUMAN
θ value	0.813845 (rank : 243)	NC score	0.105478 (rank : 220)
Query Neighborhood Hits	390	Target Neighborhood Hits	1005	Shared Neighborhood Hits	145
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

GAS7_MOUSE
θ value	0.813845 (rank : 244)	NC score	0.087628 (rank : 315)
Query Neighborhood Hits	390	Target Neighborhood Hits	259	Shared Neighborhood Hits	75
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS8_MOUSE
θ value	0.813845 (rank : 245)	NC score	0.091343 (rank : 293)
Query Neighborhood Hits	390	Target Neighborhood Hits	622	Shared Neighborhood Hits	125
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

NCF1_MOUSE
θ value	0.813845 (rank : 246)	NC score	0.222173 (rank : 133)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NOXO1_MOUSE
θ value	0.813845 (rank : 247)	NC score	0.162821 (rank : 162)
Query Neighborhood Hits	390	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NSD1_MOUSE
θ value	0.813845 (rank : 248)	NC score	0.017170 (rank : 874)
Query Neighborhood Hits	390	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

P73L_HUMAN
θ value	0.813845 (rank : 249)	NC score	0.016471 (rank : 877)
Query Neighborhood Hits	390	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

PLEC1_HUMAN
θ value	0.813845 (rank : 250)	NC score	0.067383 (rank : 596)
Query Neighborhood Hits	390	Target Neighborhood Hits	1326	Shared Neighborhood Hits	149
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

RABE1_HUMAN
θ value	0.813845 (rank : 251)	NC score	0.092641 (rank : 276)
Query Neighborhood Hits	390	Target Neighborhood Hits	1104	Shared Neighborhood Hits	153
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

REST_HUMAN
θ value	0.813845 (rank : 252)	NC score	0.095869 (rank : 261)
Query Neighborhood Hits	390	Target Neighborhood Hits	1605	Shared Neighborhood Hits	169
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

RIMB1_MOUSE
θ value	0.813845 (rank : 253)	NC score	0.145923 (rank : 176)
Query Neighborhood Hits	390	Target Neighborhood Hits	1376	Shared Neighborhood Hits	248
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TRIPB_HUMAN
θ value	0.813845 (rank : 254)	NC score	0.092379 (rank : 282)
Query Neighborhood Hits	390	Target Neighborhood Hits	1587	Shared Neighborhood Hits	170
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ASPP1_MOUSE
θ value	1.06291 (rank : 255)	NC score	0.149471 (rank : 174)
Query Neighborhood Hits	390	Target Neighborhood Hits	1244	Shared Neighborhood Hits	219
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

E2AK4_HUMAN
θ value	1.06291 (rank : 256)	NC score	0.018252 (rank : 869)
Query Neighborhood Hits	390	Target Neighborhood Hits	1012	Shared Neighborhood Hits	77
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

FLIP1_HUMAN
θ value	1.06291 (rank : 257)	NC score	0.088578 (rank : 304)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	163
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

MIA2_MOUSE
θ value	1.06291 (rank : 258)	NC score	0.039998 (rank : 834)
Query Neighborhood Hits	390	Target Neighborhood Hits	109	Shared Neighborhood Hits	20
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MYH10_HUMAN
θ value	1.06291 (rank : 259)	NC score	0.104317 (rank : 228)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	174
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH3_HUMAN
θ value	1.06291 (rank : 260)	NC score	0.114799 (rank : 192)
Query Neighborhood Hits	390	Target Neighborhood Hits	1660	Shared Neighborhood Hits	180
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH6_HUMAN
θ value	1.06291 (rank : 261)	NC score	0.099774 (rank : 243)
Query Neighborhood Hits	390	Target Neighborhood Hits	1426	Shared Neighborhood Hits	166
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PRP4B_HUMAN
θ value	1.06291 (rank : 262)	NC score	0.024025 (rank : 858)
Query Neighborhood Hits	390	Target Neighborhood Hits	1030	Shared Neighborhood Hits	75
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

RUSC1_HUMAN
θ value	1.06291 (rank : 263)	NC score	0.177697 (rank : 150)
Query Neighborhood Hits	390	Target Neighborhood Hits	226	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC2_HUMAN
θ value	1.06291 (rank : 264)	NC score	0.091674 (rank : 290)
Query Neighborhood Hits	390	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TXLNA_HUMAN
θ value	1.06291 (rank : 265)	NC score	0.076850 (rank : 447)
Query Neighborhood Hits	390	Target Neighborhood Hits	982	Shared Neighborhood Hits	127
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

ABI3_HUMAN
θ value	1.38821 (rank : 266)	NC score	0.224091 (rank : 132)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANR26_MOUSE
θ value	1.38821 (rank : 267)	NC score	0.073678 (rank : 499)
Query Neighborhood Hits	390	Target Neighborhood Hits	1554	Shared Neighborhood Hits	155
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CD2AP_MOUSE
θ value	1.38821 (rank : 268)	NC score	0.277650 (rank : 89)
Query Neighborhood Hits	390	Target Neighborhood Hits	336	Shared Neighborhood Hits	161
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

FYCO1_MOUSE
θ value	1.38821 (rank : 269)	NC score	0.076572 (rank : 449)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	132
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

HOOK1_MOUSE
θ value	1.38821 (rank : 270)	NC score	0.078632 (rank : 416)
Query Neighborhood Hits	390	Target Neighborhood Hits	910	Shared Neighborhood Hits	138
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MAST4_HUMAN
θ value	1.38821 (rank : 271)	NC score	0.012462 (rank : 885)
Query Neighborhood Hits	390	Target Neighborhood Hits	1804	Shared Neighborhood Hits	84
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MYO1E_HUMAN
θ value	1.38821 (rank : 272)	NC score	0.155972 (rank : 170)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	157
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PHLB1_MOUSE
θ value	1.38821 (rank : 273)	NC score	0.058209 (rank : 711)
Query Neighborhood Hits	390	Target Neighborhood Hits	678	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RABE1_MOUSE
θ value	1.38821 (rank : 274)	NC score	0.092020 (rank : 287)
Query Neighborhood Hits	390	Target Neighborhood Hits	1105	Shared Neighborhood Hits	153
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RAI14_MOUSE
θ value	1.38821 (rank : 275)	NC score	0.074441 (rank : 486)
Query Neighborhood Hits	390	Target Neighborhood Hits	1505	Shared Neighborhood Hits	158
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RRBP1_MOUSE
θ value	1.38821 (rank : 276)	NC score	0.076485 (rank : 451)
Query Neighborhood Hits	390	Target Neighborhood Hits	1650	Shared Neighborhood Hits	154
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TR13B_HUMAN
θ value	1.38821 (rank : 277)	NC score	0.021427 (rank : 865)
Query Neighborhood Hits	390	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O14836, Q7Z6F5	Gene names	TNFRSF13B, TACI
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD267 antigen).

TRI25_HUMAN
θ value	1.38821 (rank : 278)	NC score	0.016209 (rank : 879)
Query Neighborhood Hits	390	Target Neighborhood Hits	472	Shared Neighborhood Hits	62
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

YYAP1_HUMAN
θ value	1.38821 (rank : 279)	NC score	0.016652 (rank : 876)
Query Neighborhood Hits	390	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H869, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84	Gene names	YY1AP1, HCCA2, YY1AP
Domain Architecture	No domain graphic available
Description	YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2).

ABI3_MOUSE
θ value	1.81305 (rank : 280)	NC score	0.226717 (rank : 127)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AKAP9_HUMAN
θ value	1.81305 (rank : 281)	NC score	0.092376 (rank : 283)
Query Neighborhood Hits	390	Target Neighborhood Hits	1710	Shared Neighborhood Hits	171
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BLK_HUMAN
θ value	1.81305 (rank : 282)	NC score	0.075306 (rank : 471)
Query Neighborhood Hits	390	Target Neighborhood Hits	994	Shared Neighborhood Hits	133
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CCD11_MOUSE
θ value	1.81305 (rank : 283)	NC score	0.080812 (rank : 389)
Query Neighborhood Hits	390	Target Neighborhood Hits	498	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

GAS7_HUMAN
θ value	1.81305 (rank : 284)	NC score	0.092320 (rank : 284)
Query Neighborhood Hits	390	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

LEUK_HUMAN
θ value	1.81305 (rank : 285)	NC score	0.014357 (rank : 880)
Query Neighborhood Hits	390	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

LMNB2_HUMAN
θ value	1.81305 (rank : 286)	NC score	0.049815 (rank : 828)
Query Neighborhood Hits	390	Target Neighborhood Hits	723	Shared Neighborhood Hits	116
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

M3K11_HUMAN
θ value	1.81305 (rank : 287)	NC score	0.069176 (rank : 569)
Query Neighborhood Hits	390	Target Neighborhood Hits	1136	Shared Neighborhood Hits	159
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MAP1A_HUMAN
θ value	1.81305 (rank : 288)	NC score	0.069176 (rank : 570)
Query Neighborhood Hits	390	Target Neighborhood Hits	1626	Shared Neighborhood Hits	154
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MRCKB_MOUSE
θ value	1.81305 (rank : 289)	NC score	0.066331 (rank : 613)
Query Neighborhood Hits	390	Target Neighborhood Hits	2180	Shared Neighborhood Hits	217
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MYH9_HUMAN
θ value	1.81305 (rank : 290)	NC score	0.105133 (rank : 224)
Query Neighborhood Hits	390	Target Neighborhood Hits	1762	Shared Neighborhood Hits	181
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RLP24_MOUSE
θ value	1.81305 (rank : 291)	NC score	0.061353 (rank : 681)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q99L28	Gene names
Domain Architecture	No domain graphic available
Description	Probable ribosome biogenesis protein RLP24.

ROCK2_HUMAN
θ value	1.81305 (rank : 292)	NC score	0.054037 (rank : 759)
Query Neighborhood Hits	390	Target Neighborhood Hits	2073	Shared Neighborhood Hits	189
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SEP11_HUMAN
θ value	1.81305 (rank : 293)	NC score	0.028815 (rank : 854)
Query Neighborhood Hits	390	Target Neighborhood Hits	296	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NVA2, Q7L4N1	Gene names	SEPT11
Domain Architecture	No domain graphic available
Description	Septin-11.

ATRX_HUMAN
θ value	2.36792 (rank : 294)	NC score	0.032277 (rank : 846)
Query Neighborhood Hits	390	Target Neighborhood Hits	842	Shared Neighborhood Hits	86
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

BCAR1_MOUSE
θ value	2.36792 (rank : 295)	NC score	0.174004 (rank : 154)
Query Neighborhood Hits	390	Target Neighborhood Hits	438	Shared Neighborhood Hits	143
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CYLN2_HUMAN
θ value	2.36792 (rank : 296)	NC score	0.091986 (rank : 288)
Query Neighborhood Hits	390	Target Neighborhood Hits	1004	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

HIP1R_HUMAN
θ value	2.36792 (rank : 297)	NC score	0.075354 (rank : 469)
Query Neighborhood Hits	390	Target Neighborhood Hits	809	Shared Neighborhood Hits	131
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

OSBL6_HUMAN
θ value	2.36792 (rank : 298)	NC score	0.007998 (rank : 894)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PRP4B_MOUSE
θ value	2.36792 (rank : 299)	NC score	0.023866 (rank : 859)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	73
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

RLP24_HUMAN
θ value	2.36792 (rank : 300)	NC score	0.058101 (rank : 713)
Query Neighborhood Hits	390	Target Neighborhood Hits	63	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHA3, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1	Gene names	C15orf15, RPL24L
Domain Architecture	No domain graphic available
Description	Probable ribosome biogenesis protein RLP24 (Ribosomal protein L24- like).

SRRM1_MOUSE
θ value	2.36792 (rank : 301)	NC score	0.029052 (rank : 852)
Query Neighborhood Hits	390	Target Neighborhood Hits	966	Shared Neighborhood Hits	48
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TNNT1_MOUSE
θ value	2.36792 (rank : 302)	NC score	0.039337 (rank : 835)
Query Neighborhood Hits	390	Target Neighborhood Hits	212	Shared Neighborhood Hits	64
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

TRHY_HUMAN
θ value	2.36792 (rank : 303)	NC score	0.082227 (rank : 369)
Query Neighborhood Hits	390	Target Neighborhood Hits	1385	Shared Neighborhood Hits	152
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ANGP2_HUMAN
θ value	3.0926 (rank : 304)	NC score	0.028965 (rank : 853)
Query Neighborhood Hits	390	Target Neighborhood Hits	400	Shared Neighborhood Hits	81
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

BAT2_HUMAN
θ value	3.0926 (rank : 305)	NC score	0.029360 (rank : 851)
Query Neighborhood Hits	390	Target Neighborhood Hits	931	Shared Neighborhood Hits	47
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

C8AP2_HUMAN
θ value	3.0926 (rank : 306)	NC score	0.039042 (rank : 836)
Query Neighborhood Hits	390	Target Neighborhood Hits	548	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CASL_MOUSE
θ value	3.0926 (rank : 307)	NC score	0.138074 (rank : 181)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	122
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CDT1_MOUSE
θ value	3.0926 (rank : 308)	NC score	0.013669 (rank : 881)
Query Neighborhood Hits	390	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

FOXP2_HUMAN
θ value	3.0926 (rank : 309)	NC score	0.018118 (rank : 871)
Query Neighborhood Hits	390	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

HORN_HUMAN
θ value	3.0926 (rank : 310)	NC score	0.013269 (rank : 883)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

NIN_MOUSE
θ value	3.0926 (rank : 311)	NC score	0.087632 (rank : 314)
Query Neighborhood Hits	390	Target Neighborhood Hits	1376	Shared Neighborhood Hits	159
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

ORC1_MOUSE
θ value	3.0926 (rank : 312)	NC score	0.016429 (rank : 878)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1N2	Gene names	Orc1l, Orc1
Domain Architecture
Description	Origin recognition complex subunit 1.

PCNT_HUMAN
θ value	3.0926 (rank : 313)	NC score	0.088160 (rank : 308)
Query Neighborhood Hits	390	Target Neighborhood Hits	1551	Shared Neighborhood Hits	166
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PHLB1_HUMAN
θ value	3.0926 (rank : 314)	NC score	0.073362 (rank : 505)
Query Neighborhood Hits	390	Target Neighborhood Hits	1038	Shared Neighborhood Hits	132
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PML_MOUSE
θ value	3.0926 (rank : 315)	NC score	0.026742 (rank : 855)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

TXLNG_HUMAN
θ value	3.0926 (rank : 316)	NC score	0.071006 (rank : 539)
Query Neighborhood Hits	390	Target Neighborhood Hits	568	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

TXLNG_MOUSE
θ value	3.0926 (rank : 317)	NC score	0.073053 (rank : 508)
Query Neighborhood Hits	390	Target Neighborhood Hits	552	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

UACA_HUMAN
θ value	3.0926 (rank : 318)	NC score	0.078490 (rank : 419)
Query Neighborhood Hits	390	Target Neighborhood Hits	1622	Shared Neighborhood Hits	159
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

UACA_MOUSE
θ value	3.0926 (rank : 319)	NC score	0.082890 (rank : 356)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

WEE1B_HUMAN
θ value	3.0926 (rank : 320)	NC score	0.010901 (rank : 890)
Query Neighborhood Hits	390	Target Neighborhood Hits	836	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

ZEP1_HUMAN
θ value	3.0926 (rank : 321)	NC score	-0.006182 (rank : 900)
Query Neighborhood Hits	390	Target Neighborhood Hits	1036	Shared Neighborhood Hits	13
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

DLG2_MOUSE
θ value	4.03905 (rank : 322)	NC score	0.035514 (rank : 843)
Query Neighborhood Hits	390	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DVL3_MOUSE
θ value	4.03905 (rank : 323)	NC score	0.012282 (rank : 886)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

EEA1_HUMAN
θ value	4.03905 (rank : 324)	NC score	0.097579 (rank : 253)
Query Neighborhood Hits	390	Target Neighborhood Hits	1796	Shared Neighborhood Hits	172
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ITK_MOUSE
θ value	4.03905 (rank : 325)	NC score	0.064794 (rank : 636)
Query Neighborhood Hits	390	Target Neighborhood Hits	985	Shared Neighborhood Hits	115
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KIF2C_MOUSE
θ value	4.03905 (rank : 326)	NC score	0.011985 (rank : 887)
Query Neighborhood Hits	390	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q922S8	Gene names	Kif2c
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK).

LYN_MOUSE
θ value	4.03905 (rank : 327)	NC score	0.077603 (rank : 439)
Query Neighborhood Hits	390	Target Neighborhood Hits	1023	Shared Neighborhood Hits	142
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NDE1_HUMAN
θ value	4.03905 (rank : 328)	NC score	0.085709 (rank : 333)
Query Neighborhood Hits	390	Target Neighborhood Hits	823	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

PEPL_MOUSE
θ value	4.03905 (rank : 329)	NC score	0.080542 (rank : 391)
Query Neighborhood Hits	390	Target Neighborhood Hits	1105	Shared Neighborhood Hits	150
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PLCG2_HUMAN
θ value	4.03905 (rank : 330)	NC score	0.164687 (rank : 159)
Query Neighborhood Hits	390	Target Neighborhood Hits	280	Shared Neighborhood Hits	134
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SLK_HUMAN
θ value	4.03905 (rank : 331)	NC score	0.036892 (rank : 841)
Query Neighborhood Hits	390	Target Neighborhood Hits	1775	Shared Neighborhood Hits	174
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SMG7_HUMAN
θ value	4.03905 (rank : 332)	NC score	0.010214 (rank : 891)
Query Neighborhood Hits	390	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q92540, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2	Gene names	SMG7, C1orf16, EST1C, KIAA0250
Domain Architecture
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

SRMS_HUMAN
θ value	4.03905 (rank : 333)	NC score	0.051033 (rank : 809)
Query Neighborhood Hits	390	Target Neighborhood Hits	946	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TPR_HUMAN
θ value	4.03905 (rank : 334)	NC score	0.098207 (rank : 249)
Query Neighborhood Hits	390	Target Neighborhood Hits	1921	Shared Neighborhood Hits	167
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

1433F_HUMAN
θ value	5.27518 (rank : 335)	NC score	0.004534 (rank : 897)
Query Neighborhood Hits	390	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q04917	Gene names	YWHAH, YWHA1
Domain Architecture
Description	14-3-3 protein eta (Protein AS1).

AL2SB_HUMAN
θ value	5.27518 (rank : 336)	NC score	0.060220 (rank : 692)
Query Neighborhood Hits	390	Target Neighborhood Hits	294	Shared Neighborhood Hits	79
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

CF152_HUMAN
θ value	5.27518 (rank : 337)	NC score	0.082864 (rank : 357)
Query Neighborhood Hits	390	Target Neighborhood Hits	704	Shared Neighborhood Hits	122
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CR034_MOUSE
θ value	5.27518 (rank : 338)	NC score	0.089113 (rank : 301)
Query Neighborhood Hits	390	Target Neighborhood Hits	643	Shared Neighborhood Hits	122
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

K1024_MOUSE
θ value	5.27518 (rank : 339)	NC score	0.008395 (rank : 893)
Query Neighborhood Hits	390	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

LRC45_MOUSE
θ value	5.27518 (rank : 340)	NC score	0.079793 (rank : 402)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	127
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LYN_HUMAN
θ value	5.27518 (rank : 341)	NC score	0.078053 (rank : 428)
Query Neighborhood Hits	390	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYH11_MOUSE
θ value	5.27518 (rank : 342)	NC score	0.103680 (rank : 231)
Query Neighborhood Hits	390	Target Neighborhood Hits	1777	Shared Neighborhood Hits	181
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NDEL1_HUMAN
θ value	5.27518 (rank : 343)	NC score	0.060437 (rank : 691)
Query Neighborhood Hits	390	Target Neighborhood Hits	415	Shared Neighborhood Hits	90
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
θ value	5.27518 (rank : 344)	NC score	0.060149 (rank : 693)
Query Neighborhood Hits	390	Target Neighborhood Hits	420	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

PLCG1_MOUSE
θ value	5.27518 (rank : 345)	NC score	0.171025 (rank : 155)
Query Neighborhood Hits	390	Target Neighborhood Hits	314	Shared Neighborhood Hits	140
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PSMD9_MOUSE
θ value	5.27518 (rank : 346)	NC score	0.010985 (rank : 889)
Query Neighborhood Hits	390	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PTK6_MOUSE
θ value	5.27518 (rank : 347)	NC score	0.068656 (rank : 583)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	145
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SNX13_HUMAN
θ value	5.27518 (rank : 348)	NC score	0.018128 (rank : 870)
Query Neighborhood Hits	390	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

TIP1_HUMAN
θ value	5.27518 (rank : 349)	NC score	0.021175 (rank : 866)
Query Neighborhood Hits	390	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	O95478	Gene names	TINP1
Domain Architecture
Description	TGF-beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1).

TTC4_MOUSE
θ value	5.27518 (rank : 350)	NC score	0.011110 (rank : 888)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3H9	Gene names	Ttc4
Domain Architecture
Description	Tetratricopeptide repeat protein 4 (TPR repeat protein 4).

ZRAN1_HUMAN
θ value	5.27518 (rank : 351)	NC score	0.022083 (rank : 864)
Query Neighborhood Hits	390	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGI0	Gene names	ZRANB1, TRABID
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 1 (Protein TRABID).

BAZ2B_HUMAN
θ value	6.88961 (rank : 352)	NC score	0.038150 (rank : 837)
Query Neighborhood Hits	390	Target Neighborhood Hits	803	Shared Neighborhood Hits	101
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BCAR1_HUMAN
θ value	6.88961 (rank : 353)	NC score	0.156295 (rank : 169)
Query Neighborhood Hits	390	Target Neighborhood Hits	554	Shared Neighborhood Hits	143
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BICD2_MOUSE
θ value	6.88961 (rank : 354)	NC score	0.082483 (rank : 361)
Query Neighborhood Hits	390	Target Neighborhood Hits	864	Shared Neighborhood Hits	141
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BRE1B_HUMAN
θ value	6.88961 (rank : 355)	NC score	0.076305 (rank : 454)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	127
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	6.88961 (rank : 356)	NC score	0.070865 (rank : 542)
Query Neighborhood Hits	390	Target Neighborhood Hits	970	Shared Neighborhood Hits	125
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CYLN2_MOUSE
θ value	6.88961 (rank : 357)	NC score	0.093752 (rank : 270)
Query Neighborhood Hits	390	Target Neighborhood Hits	1002	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

GAS8_HUMAN
θ value	6.88961 (rank : 358)	NC score	0.092702 (rank : 275)
Query Neighborhood Hits	390	Target Neighborhood Hits	819	Shared Neighborhood Hits	137
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GOGB1_HUMAN
θ value	6.88961 (rank : 359)	NC score	0.101439 (rank : 237)
Query Neighborhood Hits	390	Target Neighborhood Hits	2297	Shared Neighborhood Hits	192
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ITIH2_HUMAN
θ value	6.88961 (rank : 360)	NC score	0.009114 (rank : 892)
Query Neighborhood Hits	390	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

LMNB2_MOUSE
θ value	6.88961 (rank : 361)	NC score	0.047213 (rank : 831)
Query Neighborhood Hits	390	Target Neighborhood Hits	674	Shared Neighborhood Hits	117
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

MILK2_HUMAN
θ value	6.88961 (rank : 362)	NC score	0.017814 (rank : 873)
Query Neighborhood Hits	390	Target Neighborhood Hits	457	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MYH11_HUMAN
θ value	6.88961 (rank : 363)	NC score	0.103737 (rank : 230)
Query Neighborhood Hits	390	Target Neighborhood Hits	1806	Shared Neighborhood Hits	182
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

RIMB1_HUMAN
θ value	6.88961 (rank : 364)	NC score	0.131834 (rank : 182)
Query Neighborhood Hits	390	Target Neighborhood Hits	1479	Shared Neighborhood Hits	233
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPFH2_MOUSE
θ value	6.88961 (rank : 365)	NC score	0.025624 (rank : 856)
Query Neighborhood Hits	390	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFZ9, Q8BML8	Gene names	Spfh2
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 2 precursor.

TXLNB_HUMAN
θ value	6.88961 (rank : 366)	NC score	0.067788 (rank : 591)
Query Neighborhood Hits	390	Target Neighborhood Hits	912	Shared Neighborhood Hits	118
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

1433F_MOUSE
θ value	8.99809 (rank : 367)	NC score	0.003721 (rank : 898)
Query Neighborhood Hits	390	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P68510, P11576, P70198, Q3TGZ9	Gene names	Ywhah
Domain Architecture	No domain graphic available
Description	14-3-3 protein eta.

ANR18_HUMAN
θ value	8.99809 (rank : 368)	NC score	0.059719 (rank : 697)
Query Neighborhood Hits	390	Target Neighborhood Hits	1106	Shared Neighborhood Hits	144
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ARHG4_MOUSE
θ value	8.99809 (rank : 369)	NC score	0.143894 (rank : 177)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CE152_HUMAN
θ value	8.99809 (rank : 370)	NC score	0.101321 (rank : 238)
Query Neighborhood Hits	390	Target Neighborhood Hits	976	Shared Neighborhood Hits	143
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CING_MOUSE
θ value	8.99809 (rank : 371)	NC score	0.086314 (rank : 327)
Query Neighborhood Hits	390	Target Neighborhood Hits	1432	Shared Neighborhood Hits	162
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

DESM_HUMAN
θ value	8.99809 (rank : 372)	NC score	0.029665 (rank : 849)
Query Neighborhood Hits	390	Target Neighborhood Hits	495	Shared Neighborhood Hits	101
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

DESM_MOUSE
θ value	8.99809 (rank : 373)	NC score	0.029598 (rank : 850)
Query Neighborhood Hits	390	Target Neighborhood Hits	498	Shared Neighborhood Hits	103
SwissProt Accessions	P31001	Gene names	Des
Domain Architecture
Description	Desmin.

DLG2_HUMAN
θ value	8.99809 (rank : 374)	NC score	0.030571 (rank : 848)
Query Neighborhood Hits	390	Target Neighborhood Hits	279	Shared Neighborhood Hits	70
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

GCC2_HUMAN
θ value	8.99809 (rank : 375)	NC score	0.094882 (rank : 264)
Query Neighborhood Hits	390	Target Neighborhood Hits	1558	Shared Neighborhood Hits	176
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

IF3A_MOUSE
θ value	8.99809 (rank : 376)	NC score	0.077911 (rank : 434)
Query Neighborhood Hits	390	Target Neighborhood Hits	871	Shared Neighborhood Hits	127
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

KTN1_MOUSE
θ value	8.99809 (rank : 377)	NC score	0.086728 (rank : 323)
Query Neighborhood Hits	390	Target Neighborhood Hits	1324	Shared Neighborhood Hits	158
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LUZP1_HUMAN
θ value	8.99809 (rank : 378)	NC score	0.069516 (rank : 562)
Query Neighborhood Hits	390	Target Neighborhood Hits	739	Shared Neighborhood Hits	120
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

MAK_HUMAN
θ value	8.99809 (rank : 379)	NC score	0.013267 (rank : 884)
Query Neighborhood Hits	390	Target Neighborhood Hits	857	Shared Neighborhood Hits	43
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PARPT_HUMAN
θ value	8.99809 (rank : 380)	NC score	0.003604 (rank : 899)
Query Neighborhood Hits	390	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z3E1, Q68CY9, Q86VP4, Q9Y4P7	Gene names	TIPARP, PARP7
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7).

PI51B_HUMAN
θ value	8.99809 (rank : 381)	NC score	0.006423 (rank : 896)
Query Neighborhood Hits	390	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

PLCG1_HUMAN
θ value	8.99809 (rank : 382)	NC score	0.164123 (rank : 160)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	138
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

POLK_HUMAN
θ value	8.99809 (rank : 383)	NC score	0.007967 (rank : 895)
Query Neighborhood Hits	390	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

PTK6_HUMAN
θ value	8.99809 (rank : 384)	NC score	0.068449 (rank : 585)
Query Neighborhood Hits	390	Target Neighborhood Hits	1020	Shared Neighborhood Hits	151
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

RBP24_HUMAN
θ value	8.99809 (rank : 385)	NC score	0.094749 (rank : 265)
Query Neighborhood Hits	390	Target Neighborhood Hits	1559	Shared Neighborhood Hits	177
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RGS3_MOUSE
θ value	8.99809 (rank : 386)	NC score	0.016900 (rank : 875)
Query Neighborhood Hits	390	Target Neighborhood Hits	1621	Shared Neighborhood Hits	60
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SGOL1_MOUSE
θ value	8.99809 (rank : 387)	NC score	0.034517 (rank : 845)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q9CXH7, Q3U4K4, Q588H1, Q8BKW2	Gene names	Sgol1, Sgo1
Domain Architecture	No domain graphic available
Description	Shugoshin-like 1.

SPC25_HUMAN
θ value	8.99809 (rank : 388)	NC score	0.055789 (rank : 736)
Query Neighborhood Hits	390	Target Neighborhood Hits	273	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

TIP1_MOUSE
θ value	8.99809 (rank : 389)	NC score	0.023865 (rank : 860)
Query Neighborhood Hits	390	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CR47, Q8BHQ6, Q8BHT0, Q9CRQ0, Q9CS34, Q9CYK0, Q9JKF9	Gene names	Tinp1
Domain Architecture
Description	TGF-beta-inducible nuclear protein 1 (L-name-related protein 42) (LNR42).

U2AFL_MOUSE
θ value	8.99809 (rank : 390)	NC score	0.036992 (rank : 840)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	73
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

3BP5_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.056774 (rank : 726)
Query Neighborhood Hits	390	Target Neighborhood Hits	375	Shared Neighborhood Hits	90
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

3BP5_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.055237 (rank : 745)
Query Neighborhood Hits	390	Target Neighborhood Hits	346	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

ABL1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.064902 (rank : 635)
Query Neighborhood Hits	390	Target Neighborhood Hits	1220	Shared Neighborhood Hits	134
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.064512 (rank : 638)
Query Neighborhood Hits	390	Target Neighborhood Hits	1178	Shared Neighborhood Hits	130
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.063606 (rank : 647)
Query Neighborhood Hits	390	Target Neighborhood Hits	1045	Shared Neighborhood Hits	118
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ADIP_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.061988 (rank : 677)
Query Neighborhood Hits	390	Target Neighborhood Hits	470	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

ADIP_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.055043 (rank : 747)
Query Neighborhood Hits	390	Target Neighborhood Hits	415	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

AMOL2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.053866 (rank : 761)
Query Neighborhood Hits	390	Target Neighborhood Hits	603	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

AMOL2_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.051805 (rank : 786)
Query Neighborhood Hits	390	Target Neighborhood Hits	591	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

AMOT_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.050262 (rank : 822)
Query Neighborhood Hits	390	Target Neighborhood Hits	712	Shared Neighborhood Hits	105
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

AMPH_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.051195 (rank : 804)
Query Neighborhood Hits	390	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AN30A_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.059806 (rank : 696)
Query Neighborhood Hits	390	Target Neighborhood Hits	1119	Shared Neighborhood Hits	133
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANR26_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.071113 (rank : 538)
Query Neighborhood Hits	390	Target Neighborhood Hits	1614	Shared Neighborhood Hits	154
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APOA4_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.060857 (rank : 687)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	91
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APS_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.069101 (rank : 572)
Query Neighborhood Hits	390	Target Neighborhood Hits	162	Shared Neighborhood Hits	48
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.051539 (rank : 793)
Query Neighborhood Hits	390	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.051131 (rank : 805)
Query Neighborhood Hits	390	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG3_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.074685 (rank : 482)
Query Neighborhood Hits	390	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.073734 (rank : 498)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.081462 (rank : 382)
Query Neighborhood Hits	390	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.071821 (rank : 527)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.072289 (rank : 518)
Query Neighborhood Hits	390	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.079391 (rank : 409)
Query Neighborhood Hits	390	Target Neighborhood Hits	187	Shared Neighborhood Hits	39
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.077979 (rank : 432)
Query Neighborhood Hits	390	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.050100 (rank : 825)
Query Neighborhood Hits	390	Target Neighborhood Hits	375	Shared Neighborhood Hits	45
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.065552 (rank : 625)
Query Neighborhood Hits	390	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.072485 (rank : 517)
Query Neighborhood Hits	390	Target Neighborhood Hits	152	Shared Neighborhood Hits	46
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AZI1_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.087175 (rank : 318)
Query Neighborhood Hits	390	Target Neighborhood Hits	1000	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

AZI1_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.085236 (rank : 336)
Query Neighborhood Hits	390	Target Neighborhood Hits	990	Shared Neighborhood Hits	145
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BAIP2_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.059284 (rank : 700)
Query Neighborhood Hits	390	Target Neighborhood Hits	192	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.063417 (rank : 654)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCN1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.051949 (rank : 782)
Query Neighborhood Hits	390	Target Neighborhood Hits	395	Shared Neighborhood Hits	92
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

BI2L1_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.055814 (rank : 735)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.050157 (rank : 824)
Query Neighborhood Hits	390	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BICD1_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.080850 (rank : 388)
Query Neighborhood Hits	390	Target Neighborhood Hits	844	Shared Neighborhood Hits	138
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD1_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.078993 (rank : 412)
Query Neighborhood Hits	390	Target Neighborhood Hits	837	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD2_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.084328 (rank : 343)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BIN1_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.050502 (rank : 820)
Query Neighborhood Hits	390	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BPA1_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.067679 (rank : 592)
Query Neighborhood Hits	390	Target Neighborhood Hits	1477	Shared Neighborhood Hits	152
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.071912 (rank : 525)
Query Neighborhood Hits	390	Target Neighborhood Hits	1369	Shared Neighborhood Hits	147
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BPAEA_MOUSE
θ value	θ > 10 (rank : 431)	NC score	0.078218 (rank : 426)
Query Neighborhood Hits	390	Target Neighborhood Hits	1480	Shared Neighborhood Hits	162
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRE1A_HUMAN
θ value	θ > 10 (rank : 432)	NC score	0.078285 (rank : 423)
Query Neighborhood Hits	390	Target Neighborhood Hits	1071	Shared Neighborhood Hits	147
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
θ value	θ > 10 (rank : 433)	NC score	0.080303 (rank : 394)
Query Neighborhood Hits	390	Target Neighborhood Hits	1025	Shared Neighborhood Hits	146
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

C102B_HUMAN
θ value	θ > 10 (rank : 434)	NC score	0.076896 (rank : 446)
Query Neighborhood Hits	390	Target Neighborhood Hits	542	Shared Neighborhood Hits	113
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

CA065_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.069521 (rank : 561)
Query Neighborhood Hits	390	Target Neighborhood Hits	469	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CAF1A_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.058266 (rank : 710)
Query Neighborhood Hits	390	Target Neighborhood Hits	736	Shared Neighborhood Hits	110
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CALD1_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.071640 (rank : 529)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	126
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CAR10_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.057348 (rank : 719)
Query Neighborhood Hits	390	Target Neighborhood Hits	569	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR11_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.072778 (rank : 514)
Query Neighborhood Hits	390	Target Neighborhood Hits	690	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.065396 (rank : 626)
Query Neighborhood Hits	390	Target Neighborhood Hits	449	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CAR14_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.062034 (rank : 675)
Query Neighborhood Hits	390	Target Neighborhood Hits	526	Shared Neighborhood Hits	109
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CARD9_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.081095 (rank : 385)
Query Neighborhood Hits	390	Target Neighborhood Hits	602	Shared Neighborhood Hits	124
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CASP_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.082010 (rank : 372)
Query Neighborhood Hits	390	Target Neighborhood Hits	1131	Shared Neighborhood Hits	148
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.089145 (rank : 300)
Query Neighborhood Hits	390	Target Neighborhood Hits	1152	Shared Neighborhood Hits	154
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD11_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.079564 (rank : 407)
Query Neighborhood Hits	390	Target Neighborhood Hits	822	Shared Neighborhood Hits	132
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD13_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.084167 (rank : 345)
Query Neighborhood Hits	390	Target Neighborhood Hits	721	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD19_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.076175 (rank : 455)
Query Neighborhood Hits	390	Target Neighborhood Hits	639	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.081787 (rank : 378)
Query Neighborhood Hits	390	Target Neighborhood Hits	1228	Shared Neighborhood Hits	156
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.081098 (rank : 384)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD22_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.051604 (rank : 792)
Query Neighborhood Hits	390	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD22_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.055106 (rank : 746)
Query Neighborhood Hits	390	Target Neighborhood Hits	268	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD27_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.068741 (rank : 580)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	108
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD27_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.070885 (rank : 541)
Query Neighborhood Hits	390	Target Neighborhood Hits	461	Shared Neighborhood Hits	105
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD39_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.081591 (rank : 380)
Query Neighborhood Hits	390	Target Neighborhood Hits	868	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD39_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.091638 (rank : 291)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	145
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.084031 (rank : 347)
Query Neighborhood Hits	390	Target Neighborhood Hits	1139	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD41_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.086824 (rank : 322)
Query Neighborhood Hits	390	Target Neighborhood Hits	1399	Shared Neighborhood Hits	162
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCD42_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.064079 (rank : 641)
Query Neighborhood Hits	390	Target Neighborhood Hits	406	Shared Neighborhood Hits	90
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD45_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.068809 (rank : 577)
Query Neighborhood Hits	390	Target Neighborhood Hits	525	Shared Neighborhood Hits	114
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD45_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.059403 (rank : 699)
Query Neighborhood Hits	390	Target Neighborhood Hits	663	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD62_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.083657 (rank : 351)
Query Neighborhood Hits	390	Target Neighborhood Hits	631	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CCD91_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.069828 (rank : 555)
Query Neighborhood Hits	390	Target Neighborhood Hits	868	Shared Neighborhood Hits	124
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CCD91_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.073454 (rank : 503)
Query Neighborhood Hits	390	Target Neighborhood Hits	699	Shared Neighborhood Hits	122
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CCD93_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.067080 (rank : 601)
Query Neighborhood Hits	390	Target Neighborhood Hits	600	Shared Neighborhood Hits	113
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD93_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.051683 (rank : 791)
Query Neighborhood Hits	390	Target Neighborhood Hits	362	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD96_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.072002 (rank : 521)
Query Neighborhood Hits	390	Target Neighborhood Hits	595	Shared Neighborhood Hits	112
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.076457 (rank : 452)
Query Neighborhood Hits	390	Target Neighborhood Hits	704	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.074546 (rank : 484)
Query Neighborhood Hits	390	Target Neighborhood Hits	723	Shared Neighborhood Hits	128
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.074152 (rank : 491)
Query Neighborhood Hits	390	Target Neighborhood Hits	717	Shared Neighborhood Hits	120
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CCHCR_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.078676 (rank : 415)
Query Neighborhood Hits	390	Target Neighborhood Hits	932	Shared Neighborhood Hits	140
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CDC37_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.054590 (rank : 751)
Query Neighborhood Hits	390	Target Neighborhood Hits	506	Shared Neighborhood Hits	92
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CDR2_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.050950 (rank : 814)
Query Neighborhood Hits	390	Target Neighborhood Hits	404	Shared Neighborhood Hits	89
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CDR2_MOUSE
θ value	θ > 10 (rank : 473)	NC score	0.066067 (rank : 619)
Query Neighborhood Hits	390	Target Neighborhood Hits	482	Shared Neighborhood Hits	100
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CE290_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.094934 (rank : 262)
Query Neighborhood Hits	390	Target Neighborhood Hits	1553	Shared Neighborhood Hits	167
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CENB1_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.058704 (rank : 708)
Query Neighborhood Hits	390	Target Neighborhood Hits	383	Shared Neighborhood Hits	25
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.066705 (rank : 606)
Query Neighborhood Hits	390	Target Neighborhood Hits	425	Shared Neighborhood Hits	47
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.061436 (rank : 680)
Query Neighborhood Hits	390	Target Neighborhood Hits	395	Shared Neighborhood Hits	34
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENPH_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.058856 (rank : 705)
Query Neighborhood Hits	390	Target Neighborhood Hits	335	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

CENPJ_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.065001 (rank : 633)
Query Neighborhood Hits	390	Target Neighborhood Hits	721	Shared Neighborhood Hits	122
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CEP35_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.054817 (rank : 749)
Query Neighborhood Hits	390	Target Neighborhood Hits	811	Shared Neighborhood Hits	112
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CEP55_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.073567 (rank : 502)
Query Neighborhood Hits	390	Target Neighborhood Hits	504	Shared Neighborhood Hits	105
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

CEP55_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.087929 (rank : 310)
Query Neighborhood Hits	390	Target Neighborhood Hits	693	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CEP57_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.063515 (rank : 651)
Query Neighborhood Hits	390	Target Neighborhood Hits	576	Shared Neighborhood Hits	113
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CEP57_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.063575 (rank : 649)
Query Neighborhood Hits	390	Target Neighborhood Hits	580	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CEP70_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.062824 (rank : 661)
Query Neighborhood Hits	390	Target Neighborhood Hits	432	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

CEP70_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.056373 (rank : 728)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	102
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.082400 (rank : 362)
Query Neighborhood Hits	390	Target Neighborhood Hits	1270	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CF152_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.066493 (rank : 610)
Query Neighborhood Hits	390	Target Neighborhood Hits	597	Shared Neighborhood Hits	116
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CF182_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.060621 (rank : 688)
Query Neighborhood Hits	390	Target Neighborhood Hits	474	Shared Neighborhood Hits	104
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

CF182_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.064037 (rank : 642)
Query Neighborhood Hits	390	Target Neighborhood Hits	551	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CI093_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.098776 (rank : 245)
Query Neighborhood Hits	390	Target Neighborhood Hits	1088	Shared Neighborhood Hits	153
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CING_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.085307 (rank : 335)
Query Neighborhood Hits	390	Target Neighborhood Hits	1275	Shared Neighborhood Hits	153
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CJ118_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.077928 (rank : 433)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	133
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

CJ118_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.084306 (rank : 344)
Query Neighborhood Hits	390	Target Neighborhood Hits	1132	Shared Neighborhood Hits	139
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CK5P2_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.087816 (rank : 311)
Query Neighborhood Hits	390	Target Neighborhood Hits	1433	Shared Neighborhood Hits	168
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CK5P2_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.079782 (rank : 403)
Query Neighborhood Hits	390	Target Neighborhood Hits	1151	Shared Neighborhood Hits	145
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CKAP4_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.067874 (rank : 587)
Query Neighborhood Hits	390	Target Neighborhood Hits	592	Shared Neighborhood Hits	106
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CKAP4_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.066461 (rank : 611)
Query Neighborhood Hits	390	Target Neighborhood Hits	596	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CN145_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.092584 (rank : 278)
Query Neighborhood Hits	390	Target Neighborhood Hits	1196	Shared Neighborhood Hits	154
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CN145_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.082052 (rank : 370)
Query Neighborhood Hits	390	Target Neighborhood Hits	916	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNTRB_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.071336 (rank : 533)
Query Neighborhood Hits	390	Target Neighborhood Hits	690	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CNTRB_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.075064 (rank : 478)
Query Neighborhood Hits	390	Target Neighborhood Hits	1029	Shared Neighborhood Hits	138
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP135_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.087126 (rank : 319)
Query Neighborhood Hits	390	Target Neighborhood Hits	1290	Shared Neighborhood Hits	162
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP135_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.087387 (rank : 316)
Query Neighborhood Hits	390	Target Neighborhood Hits	1278	Shared Neighborhood Hits	155
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CP250_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.085150 (rank : 339)
Query Neighborhood Hits	390	Target Neighborhood Hits	1583	Shared Neighborhood Hits	165
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CRCM_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.068829 (rank : 576)
Query Neighborhood Hits	390	Target Neighborhood Hits	520	Shared Neighborhood Hits	105
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

CROCC_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.087753 (rank : 312)
Query Neighborhood Hits	390	Target Neighborhood Hits	1409	Shared Neighborhood Hits	154
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CROCC_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.081950 (rank : 373)
Query Neighborhood Hits	390	Target Neighborhood Hits	1460	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CSK_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.068861 (rank : 575)
Query Neighborhood Hits	390	Target Neighborhood Hits	1009	Shared Neighborhood Hits	125
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.068762 (rank : 579)
Query Neighborhood Hits	390	Target Neighborhood Hits	1009	Shared Neighborhood Hits	125
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.143779 (rank : 178)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT096_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.078575 (rank : 417)
Query Neighborhood Hits	390	Target Neighborhood Hits	438	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

CT2NL_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.082688 (rank : 359)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.072047 (rank : 519)
Query Neighborhood Hits	390	Target Neighborhood Hits	902	Shared Neighborhood Hits	135
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CTGE2_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.054077 (rank : 758)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

CTGE5_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.070234 (rank : 548)
Query Neighborhood Hits	390	Target Neighborhood Hits	800	Shared Neighborhood Hits	131
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

CTGE5_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.071913 (rank : 524)
Query Neighborhood Hits	390	Target Neighborhood Hits	928	Shared Neighborhood Hits	131
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

CTGE6_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.061654 (rank : 679)
Query Neighborhood Hits	390	Target Neighborhood Hits	650	Shared Neighborhood Hits	113
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

CTRO_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.051530 (rank : 794)
Query Neighborhood Hits	390	Target Neighborhood Hits	2092	Shared Neighborhood Hits	188
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.059943 (rank : 695)
Query Neighborhood Hits	390	Target Neighborhood Hits	2344	Shared Neighborhood Hits	208
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CU013_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.071446 (rank : 530)
Query Neighborhood Hits	390	Target Neighborhood Hits	405	Shared Neighborhood Hits	101
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

CUTL1_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.068650 (rank : 584)
Query Neighborhood Hits	390	Target Neighborhood Hits	1574	Shared Neighborhood Hits	151
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.080695 (rank : 390)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	161
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CYTSA_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.074160 (rank : 490)
Query Neighborhood Hits	390	Target Neighborhood Hits	1138	Shared Neighborhood Hits	150
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.075209 (rank : 474)
Query Neighborhood Hits	390	Target Neighborhood Hits	1104	Shared Neighborhood Hits	147
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DAPP1_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.112502 (rank : 201)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.112703 (rank : 198)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DBNL_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.157993 (rank : 167)
Query Neighborhood Hits	390	Target Neighborhood Hits	244	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.154422 (rank : 173)
Query Neighborhood Hits	390	Target Neighborhood Hits	306	Shared Neighborhood Hits	140
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.114169 (rank : 194)
Query Neighborhood Hits	390	Target Neighborhood Hits	592	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.112627 (rank : 199)
Query Neighborhood Hits	390	Target Neighborhood Hits	599	Shared Neighborhood Hits	151
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.111659 (rank : 204)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	148
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DESP_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.088290 (rank : 306)
Query Neighborhood Hits	390	Target Neighborhood Hits	1470	Shared Neighborhood Hits	169
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DMD_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.066925 (rank : 604)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	146
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.069586 (rank : 560)
Query Neighborhood Hits	390	Target Neighborhood Hits	1111	Shared Neighborhood Hits	150
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DOCK1_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.057592 (rank : 716)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	92
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DP13A_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.050420 (rank : 821)
Query Neighborhood Hits	390	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DYNA_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.069437 (rank : 564)
Query Neighborhood Hits	390	Target Neighborhood Hits	1194	Shared Neighborhood Hits	142
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.069811 (rank : 556)
Query Neighborhood Hits	390	Target Neighborhood Hits	1084	Shared Neighborhood Hits	141
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

ECT2_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.069715 (rank : 557)
Query Neighborhood Hits	390	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.070508 (rank : 545)
Query Neighborhood Hits	390	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EEA1_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.088962 (rank : 302)
Query Neighborhood Hits	390	Target Neighborhood Hits	1637	Shared Neighborhood Hits	164
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EFS_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.162146 (rank : 163)
Query Neighborhood Hits	390	Target Neighborhood Hits	348	Shared Neighborhood Hits	131
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 544)	NC score	0.159731 (rank : 165)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ENAH_HUMAN
θ value	θ > 10 (rank : 545)	NC score	0.050593 (rank : 817)
Query Neighborhood Hits	390	Target Neighborhood Hits	784	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

EP15R_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.083725 (rank : 350)
Query Neighborhood Hits	390	Target Neighborhood Hits	1083	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.081024 (rank : 387)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	141
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EP15_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.079282 (rank : 410)
Query Neighborhood Hits	390	Target Neighborhood Hits	1021	Shared Neighborhood Hits	139
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.070051 (rank : 550)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	120
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.082347 (rank : 365)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	91
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERC2_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.082300 (rank : 366)
Query Neighborhood Hits	390	Target Neighborhood Hits	1156	Shared Neighborhood Hits	156
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.081836 (rank : 377)
Query Neighborhood Hits	390	Target Neighborhood Hits	1166	Shared Neighborhood Hits	158
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

ES8L1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.087950 (rank : 309)
Query Neighborhood Hits	390	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 554)	NC score	0.098224 (rank : 248)
Query Neighborhood Hits	390	Target Neighborhood Hits	143	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.093191 (rank : 273)
Query Neighborhood Hits	390	Target Neighborhood Hits	193	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.083197 (rank : 355)
Query Neighborhood Hits	390	Target Neighborhood Hits	169	Shared Neighborhood Hits	103
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.104903 (rank : 226)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 558)	NC score	0.113829 (rank : 195)
Query Neighborhood Hits	390	Target Neighborhood Hits	168	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EVPL_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.074666 (rank : 483)
Query Neighborhood Hits	390	Target Neighborhood Hits	895	Shared Neighborhood Hits	138
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
θ value	θ > 10 (rank : 560)	NC score	0.072793 (rank : 513)
Query Neighborhood Hits	390	Target Neighborhood Hits	952	Shared Neighborhood Hits	138
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

EZRI_HUMAN
θ value	θ > 10 (rank : 561)	NC score	0.065213 (rank : 627)
Query Neighborhood Hits	390	Target Neighborhood Hits	663	Shared Neighborhood Hits	108
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FARP1_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.050557 (rank : 818)
Query Neighborhood Hits	390	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.053677 (rank : 762)
Query Neighborhood Hits	390	Target Neighborhood Hits	240	Shared Neighborhood Hits	38
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.057121 (rank : 722)
Query Neighborhood Hits	390	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD2_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.051368 (rank : 797)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD3_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.051322 (rank : 800)
Query Neighborhood Hits	390	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 567)	NC score	0.054756 (rank : 750)
Query Neighborhood Hits	390	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.056836 (rank : 724)
Query Neighborhood Hits	390	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.058164 (rank : 712)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.050003 (rank : 827)
Query Neighborhood Hits	390	Target Neighborhood Hits	237	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.051795 (rank : 788)
Query Neighborhood Hits	390	Target Neighborhood Hits	282	Shared Neighborhood Hits	39
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FLIP1_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.082348 (rank : 364)
Query Neighborhood Hits	390	Target Neighborhood Hits	1176	Shared Neighborhood Hits	150
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FYCO1_HUMAN
θ value	θ > 10 (rank : 573)	NC score	0.075038 (rank : 479)
Query Neighborhood Hits	390	Target Neighborhood Hits	1149	Shared Neighborhood Hits	143
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

GCC1_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.070568 (rank : 544)
Query Neighborhood Hits	390	Target Neighborhood Hits	887	Shared Neighborhood Hits	126
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC1_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.070000 (rank : 551)
Query Neighborhood Hits	390	Target Neighborhood Hits	777	Shared Neighborhood Hits	122
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC2_MOUSE
θ value	θ > 10 (rank : 576)	NC score	0.093691 (rank : 271)
Query Neighborhood Hits	390	Target Neighborhood Hits	1619	Shared Neighborhood Hits	169
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GLE1_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.058848 (rank : 706)
Query Neighborhood Hits	390	Target Neighborhood Hits	504	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GNRP_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.066252 (rank : 615)
Query Neighborhood Hits	390	Target Neighborhood Hits	239	Shared Neighborhood Hits	46
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.067006 (rank : 602)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	33
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GOG8A_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.072039 (rank : 520)
Query Neighborhood Hits	390	Target Neighborhood Hits	635	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

GOGA1_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.088175 (rank : 307)
Query Neighborhood Hits	390	Target Neighborhood Hits	1222	Shared Neighborhood Hits	148
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.085013 (rank : 340)
Query Neighborhood Hits	390	Target Neighborhood Hits	994	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.074428 (rank : 487)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	123
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.085837 (rank : 331)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	140
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GOGA3_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.083493 (rank : 352)
Query Neighborhood Hits	390	Target Neighborhood Hits	1317	Shared Neighborhood Hits	151
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA4_HUMAN
θ value	θ > 10 (rank : 586)	NC score	0.096845 (rank : 256)
Query Neighborhood Hits	390	Target Neighborhood Hits	2034	Shared Neighborhood Hits	186
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GP73_MOUSE
θ value	θ > 10 (rank : 587)	NC score	0.050896 (rank : 815)
Query Neighborhood Hits	390	Target Neighborhood Hits	506	Shared Neighborhood Hits	92
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

GRAP1_HUMAN
θ value	θ > 10 (rank : 588)	NC score	0.085542 (rank : 334)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	136
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
θ value	θ > 10 (rank : 589)	NC score	0.081731 (rank : 379)
Query Neighborhood Hits	390	Target Neighborhood Hits	1234	Shared Neighborhood Hits	154
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRB10_HUMAN
θ value	θ > 10 (rank : 590)	NC score	0.052994 (rank : 770)
Query Neighborhood Hits	390	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 591)	NC score	0.055693 (rank : 738)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 592)	NC score	0.069429 (rank : 565)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.068942 (rank : 573)
Query Neighborhood Hits	390	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.056141 (rank : 732)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.059689 (rank : 698)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.078296 (rank : 422)
Query Neighborhood Hits	390	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HAP1_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.069484 (rank : 563)
Query Neighborhood Hits	390	Target Neighborhood Hits	606	Shared Neighborhood Hits	117
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

HAPIP_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.074093 (rank : 493)
Query Neighborhood Hits	390	Target Neighborhood Hits	350	Shared Neighborhood Hits	81
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HC127_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.050995 (rank : 811)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.050995 (rank : 812)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

HIP1R_MOUSE
θ value	θ > 10 (rank : 601)	NC score	0.075660 (rank : 460)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	136
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

HIP1_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.077717 (rank : 436)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	142
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HMMR_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.083760 (rank : 349)
Query Neighborhood Hits	390	Target Neighborhood Hits	1082	Shared Neighborhood Hits	142
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HMMR_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.091819 (rank : 289)
Query Neighborhood Hits	390	Target Neighborhood Hits	1178	Shared Neighborhood Hits	151
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HOME1_MOUSE
θ value	θ > 10 (rank : 605)	NC score	0.052157 (rank : 776)
Query Neighborhood Hits	390	Target Neighborhood Hits	630	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

HOME2_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.067118 (rank : 600)
Query Neighborhood Hits	390	Target Neighborhood Hits	882	Shared Neighborhood Hits	139
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

HOOK1_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.075138 (rank : 475)
Query Neighborhood Hits	390	Target Neighborhood Hits	942	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

HOOK2_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.063988 (rank : 643)
Query Neighborhood Hits	390	Target Neighborhood Hits	714	Shared Neighborhood Hits	119
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

HOOK2_MOUSE
θ value	θ > 10 (rank : 609)	NC score	0.063464 (rank : 652)
Query Neighborhood Hits	390	Target Neighborhood Hits	736	Shared Neighborhood Hits	118
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

HOOK3_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.090365 (rank : 298)
Query Neighborhood Hits	390	Target Neighborhood Hits	1070	Shared Neighborhood Hits	158
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.087070 (rank : 320)
Query Neighborhood Hits	390	Target Neighborhood Hits	1007	Shared Neighborhood Hits	151
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

HSH2D_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.066649 (rank : 608)
Query Neighborhood Hits	390	Target Neighborhood Hits	159	Shared Neighborhood Hits	44
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF2P_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.063125 (rank : 658)
Query Neighborhood Hits	390	Target Neighborhood Hits	889	Shared Neighborhood Hits	117
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IF3A_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.075324 (rank : 470)
Query Neighborhood Hits	390	Target Neighborhood Hits	875	Shared Neighborhood Hits	126
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IFT74_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.090726 (rank : 297)
Query Neighborhood Hits	390	Target Neighborhood Hits	949	Shared Neighborhood Hits	149
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT74_MOUSE
θ value	θ > 10 (rank : 616)	NC score	0.090769 (rank : 296)
Query Neighborhood Hits	390	Target Neighborhood Hits	939	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.087267 (rank : 317)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	143
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IMMT_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.054287 (rank : 755)
Query Neighborhood Hits	390	Target Neighborhood Hits	494	Shared Neighborhood Hits	91
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

INCE_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.072838 (rank : 512)
Query Neighborhood Hits	390	Target Neighborhood Hits	978	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	θ > 10 (rank : 620)	NC score	0.073453 (rank : 504)
Query Neighborhood Hits	390	Target Neighborhood Hits	903	Shared Neighborhood Hits	126
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INVO_HUMAN
θ value	θ > 10 (rank : 621)	NC score	0.073862 (rank : 496)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	107
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

INVO_MOUSE
θ value	θ > 10 (rank : 622)	NC score	0.052791 (rank : 773)
Query Neighborhood Hits	390	Target Neighborhood Hits	474	Shared Neighborhood Hits	79
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

K0552_HUMAN
θ value	θ > 10 (rank : 623)	NC score	0.054113 (rank : 757)
Query Neighborhood Hits	390	Target Neighborhood Hits	442	Shared Neighborhood Hits	91
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

K0555_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.084122 (rank : 346)
Query Neighborhood Hits	390	Target Neighborhood Hits	880	Shared Neighborhood Hits	140
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

KIF4A_HUMAN
θ value	θ > 10 (rank : 625)	NC score	0.061961 (rank : 678)
Query Neighborhood Hits	390	Target Neighborhood Hits	1159	Shared Neighborhood Hits	146
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.052961 (rank : 771)
Query Neighborhood Hits	390	Target Neighborhood Hits	1033	Shared Neighborhood Hits	138
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF5C_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.052653 (rank : 774)
Query Neighborhood Hits	390	Target Neighborhood Hits	974	Shared Neighborhood Hits	142
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.056423 (rank : 727)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	152
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KINH_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.062820 (rank : 662)
Query Neighborhood Hits	390	Target Neighborhood Hits	1231	Shared Neighborhood Hits	156
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KINH_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.059110 (rank : 701)
Query Neighborhood Hits	390	Target Neighborhood Hits	1082	Shared Neighborhood Hits	147
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KMHN1_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.086719 (rank : 324)
Query Neighborhood Hits	390	Target Neighborhood Hits	950	Shared Neighborhood Hits	146
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KMHN1_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.077534 (rank : 442)
Query Neighborhood Hits	390	Target Neighborhood Hits	949	Shared Neighborhood Hits	141
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KNTC2_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.076089 (rank : 456)
Query Neighborhood Hits	390	Target Neighborhood Hits	673	Shared Neighborhood Hits	127
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

KNTC2_MOUSE
θ value	θ > 10 (rank : 634)	NC score	0.071364 (rank : 532)
Query Neighborhood Hits	390	Target Neighborhood Hits	692	Shared Neighborhood Hits	119
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

LASP1_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.155789 (rank : 171)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.155251 (rank : 172)
Query Neighborhood Hits	390	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LBN_MOUSE
θ value	θ > 10 (rank : 637)	NC score	0.053285 (rank : 765)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

LCK_HUMAN
θ value	θ > 10 (rank : 638)	NC score	0.063444 (rank : 653)
Query Neighborhood Hits	390	Target Neighborhood Hits	987	Shared Neighborhood Hits	112
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 639)	NC score	0.063080 (rank : 659)
Query Neighborhood Hits	390	Target Neighborhood Hits	981	Shared Neighborhood Hits	112
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LIPA3_HUMAN
θ value	θ > 10 (rank : 640)	NC score	0.074766 (rank : 480)
Query Neighborhood Hits	390	Target Neighborhood Hits	828	Shared Neighborhood Hits	132
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA3_MOUSE
θ value	θ > 10 (rank : 641)	NC score	0.065790 (rank : 621)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	117
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPB1_HUMAN
θ value	θ > 10 (rank : 642)	NC score	0.063404 (rank : 655)
Query Neighborhood Hits	390	Target Neighborhood Hits	640	Shared Neighborhood Hits	108
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

LIPB1_MOUSE
θ value	θ > 10 (rank : 643)	NC score	0.066299 (rank : 614)
Query Neighborhood Hits	390	Target Neighborhood Hits	727	Shared Neighborhood Hits	117
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LIPB2_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.058292 (rank : 709)
Query Neighborhood Hits	390	Target Neighborhood Hits	599	Shared Neighborhood Hits	107
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

LIPB2_MOUSE
θ value	θ > 10 (rank : 645)	NC score	0.056199 (rank : 730)
Query Neighborhood Hits	390	Target Neighborhood Hits	570	Shared Neighborhood Hits	99
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

LMNB1_HUMAN
θ value	θ > 10 (rank : 646)	NC score	0.052795 (rank : 772)
Query Neighborhood Hits	390	Target Neighborhood Hits	714	Shared Neighborhood Hits	131
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

LMNB1_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.051324 (rank : 799)
Query Neighborhood Hits	390	Target Neighborhood Hits	719	Shared Neighborhood Hits	127
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

LNK_HUMAN
θ value	θ > 10 (rank : 648)	NC score	0.056962 (rank : 723)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 649)	NC score	0.055872 (rank : 733)
Query Neighborhood Hits	390	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC45_HUMAN
θ value	θ > 10 (rank : 650)	NC score	0.079811 (rank : 401)
Query Neighborhood Hits	390	Target Neighborhood Hits	933	Shared Neighborhood Hits	133
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF1_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.053090 (rank : 768)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	107
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LRRF2_HUMAN
θ value	θ > 10 (rank : 652)	NC score	0.079578 (rank : 406)
Query Neighborhood Hits	390	Target Neighborhood Hits	791	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRF2_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.074401 (rank : 488)
Query Neighborhood Hits	390	Target Neighborhood Hits	556	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRSM1_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.051294 (rank : 802)
Query Neighborhood Hits	390	Target Neighborhood Hits	1078	Shared Neighborhood Hits	124
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LUZP1_MOUSE
θ value	θ > 10 (rank : 655)	NC score	0.069120 (rank : 571)
Query Neighborhood Hits	390	Target Neighborhood Hits	940	Shared Neighborhood Hits	124
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

LZTS1_HUMAN
θ value	θ > 10 (rank : 656)	NC score	0.060893 (rank : 685)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS1_MOUSE
θ value	θ > 10 (rank : 657)	NC score	0.059106 (rank : 702)
Query Neighborhood Hits	390	Target Neighborhood Hits	540	Shared Neighborhood Hits	102
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS2_HUMAN
θ value	θ > 10 (rank : 658)	NC score	0.055766 (rank : 737)
Query Neighborhood Hits	390	Target Neighborhood Hits	427	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

LZTS2_MOUSE
θ value	θ > 10 (rank : 659)	NC score	0.050553 (rank : 819)
Query Neighborhood Hits	390	Target Neighborhood Hits	423	Shared Neighborhood Hits	86
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

M3K10_HUMAN
θ value	θ > 10 (rank : 660)	NC score	0.055428 (rank : 742)
Query Neighborhood Hits	390	Target Neighborhood Hits	1071	Shared Neighborhood Hits	164
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.065032 (rank : 632)
Query Neighborhood Hits	390	Target Neighborhood Hits	1123	Shared Neighborhood Hits	173
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 662)	NC score	0.067471 (rank : 593)
Query Neighborhood Hits	390	Target Neighborhood Hits	1087	Shared Neighborhood Hits	182
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MACF1_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.061204 (rank : 682)
Query Neighborhood Hits	390	Target Neighborhood Hits	1341	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF1_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.064919 (rank : 634)
Query Neighborhood Hits	390	Target Neighborhood Hits	1313	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF4_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.067445 (rank : 595)
Query Neighborhood Hits	390	Target Neighborhood Hits	1321	Shared Neighborhood Hits	151
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MACOI_HUMAN
θ value	θ > 10 (rank : 666)	NC score	0.071385 (rank : 531)
Query Neighborhood Hits	390	Target Neighborhood Hits	650	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	θ > 10 (rank : 667)	NC score	0.072889 (rank : 510)
Query Neighborhood Hits	390	Target Neighborhood Hits	620	Shared Neighborhood Hits	114
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MATK_HUMAN
θ value	θ > 10 (rank : 668)	NC score	0.051417 (rank : 795)
Query Neighborhood Hits	390	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 669)	NC score	0.052099 (rank : 778)
Query Neighborhood Hits	390	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.073673 (rank : 500)
Query Neighborhood Hits	390	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.069237 (rank : 568)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MD1L1_HUMAN
θ value	θ > 10 (rank : 672)	NC score	0.078051 (rank : 429)
Query Neighborhood Hits	390	Target Neighborhood Hits	893	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MD1L1_MOUSE
θ value	θ > 10 (rank : 673)	NC score	0.079608 (rank : 405)
Query Neighborhood Hits	390	Target Neighborhood Hits	1001	Shared Neighborhood Hits	134
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MERL_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.060117 (rank : 694)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	104
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 675)	NC score	0.060562 (rank : 689)
Query Neighborhood Hits	390	Target Neighborhood Hits	524	Shared Neighborhood Hits	99
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MIPO1_HUMAN
θ value	θ > 10 (rank : 676)	NC score	0.066949 (rank : 603)
Query Neighborhood Hits	390	Target Neighborhood Hits	486	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

MMRN1_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.062082 (rank : 674)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	107
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

MORC3_HUMAN
θ value	θ > 10 (rank : 678)	NC score	0.053252 (rank : 766)
Query Neighborhood Hits	390	Target Neighborhood Hits	489	Shared Neighborhood Hits	100
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

MPP9_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.067849 (rank : 588)
Query Neighborhood Hits	390	Target Neighborhood Hits	529	Shared Neighborhood Hits	110
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

MRCKB_HUMAN
θ value	θ > 10 (rank : 680)	NC score	0.065208 (rank : 628)
Query Neighborhood Hits	390	Target Neighborhood Hits	2239	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRIP_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.051729 (rank : 790)
Query Neighborhood Hits	390	Target Neighborhood Hits	578	Shared Neighborhood Hits	95
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.050971 (rank : 813)
Query Neighborhood Hits	390	Target Neighborhood Hits	569	Shared Neighborhood Hits	97
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MY18B_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.098133 (rank : 250)
Query Neighborhood Hits	390	Target Neighborhood Hits	1299	Shared Neighborhood Hits	155
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH13_HUMAN
θ value	θ > 10 (rank : 684)	NC score	0.098251 (rank : 247)
Query Neighborhood Hits	390	Target Neighborhood Hits	1504	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH14_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.089363 (rank : 299)
Query Neighborhood Hits	390	Target Neighborhood Hits	995	Shared Neighborhood Hits	130
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH14_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.094269 (rank : 267)
Query Neighborhood Hits	390	Target Neighborhood Hits	1225	Shared Neighborhood Hits	152
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH2_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.101741 (rank : 236)
Query Neighborhood Hits	390	Target Neighborhood Hits	1491	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH7_HUMAN
θ value	θ > 10 (rank : 688)	NC score	0.098437 (rank : 246)
Query Neighborhood Hits	390	Target Neighborhood Hits	1559	Shared Neighborhood Hits	170
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYO10_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.097956 (rank : 251)
Query Neighborhood Hits	390	Target Neighborhood Hits	920	Shared Neighborhood Hits	133
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO15_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.068936 (rank : 574)
Query Neighborhood Hits	390	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO15_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.071278 (rank : 535)
Query Neighborhood Hits	390	Target Neighborhood Hits	467	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO1A_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.062911 (rank : 660)
Query Neighborhood Hits	390	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

MYO1B_HUMAN
θ value	θ > 10 (rank : 693)	NC score	0.062528 (rank : 669)
Query Neighborhood Hits	390	Target Neighborhood Hits	70	Shared Neighborhood Hits	23
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

MYO1B_MOUSE
θ value	θ > 10 (rank : 694)	NC score	0.062528 (rank : 668)
Query Neighborhood Hits	390	Target Neighborhood Hits	71	Shared Neighborhood Hits	23
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

MYO1C_HUMAN
θ value	θ > 10 (rank : 695)	NC score	0.062632 (rank : 666)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

MYO1C_MOUSE
θ value	θ > 10 (rank : 696)	NC score	0.062756 (rank : 664)
Query Neighborhood Hits	390	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

MYO1D_HUMAN
θ value	θ > 10 (rank : 697)	NC score	0.062501 (rank : 670)
Query Neighborhood Hits	390	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

MYO1D_MOUSE
θ value	θ > 10 (rank : 698)	NC score	0.062378 (rank : 671)
Query Neighborhood Hits	390	Target Neighborhood Hits	57	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

MYO5A_HUMAN
θ value	θ > 10 (rank : 699)	NC score	0.092263 (rank : 286)
Query Neighborhood Hits	390	Target Neighborhood Hits	1092	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 700)	NC score	0.092544 (rank : 279)
Query Neighborhood Hits	390	Target Neighborhood Hits	1117	Shared Neighborhood Hits	148
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5B_HUMAN
θ value	θ > 10 (rank : 701)	NC score	0.088869 (rank : 303)
Query Neighborhood Hits	390	Target Neighborhood Hits	911	Shared Neighborhood Hits	133
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.101979 (rank : 235)
Query Neighborhood Hits	390	Target Neighborhood Hits	1206	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 703)	NC score	0.082819 (rank : 358)
Query Neighborhood Hits	390	Target Neighborhood Hits	727	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 704)	NC score	0.079682 (rank : 404)
Query Neighborhood Hits	390	Target Neighborhood Hits	586	Shared Neighborhood Hits	103
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_HUMAN
θ value	θ > 10 (rank : 705)	NC score	0.072659 (rank : 515)
Query Neighborhood Hits	390	Target Neighborhood Hits	209	Shared Neighborhood Hits	59
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_MOUSE
θ value	θ > 10 (rank : 706)	NC score	0.074315 (rank : 489)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NCF1_HUMAN
θ value	θ > 10 (rank : 707)	NC score	0.198036 (rank : 144)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	128
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NDE1_MOUSE
θ value	θ > 10 (rank : 708)	NC score	0.070438 (rank : 546)
Query Neighborhood Hits	390	Target Neighborhood Hits	602	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

NEB2_HUMAN
θ value	θ > 10 (rank : 709)	NC score	0.051018 (rank : 810)
Query Neighborhood Hits	390	Target Neighborhood Hits	883	Shared Neighborhood Hits	124
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 710)	NC score	0.052106 (rank : 777)
Query Neighborhood Hits	390	Target Neighborhood Hits	889	Shared Neighborhood Hits	126
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEBL_HUMAN
θ value	θ > 10 (rank : 711)	NC score	0.176093 (rank : 152)
Query Neighborhood Hits	390	Target Neighborhood Hits	457	Shared Neighborhood Hits	182
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEMO_HUMAN
θ value	θ > 10 (rank : 712)	NC score	0.077646 (rank : 438)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEMO_MOUSE
θ value	θ > 10 (rank : 713)	NC score	0.075104 (rank : 477)
Query Neighborhood Hits	390	Target Neighborhood Hits	658	Shared Neighborhood Hits	118
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NEST_HUMAN
θ value	θ > 10 (rank : 714)	NC score	0.063226 (rank : 657)
Query Neighborhood Hits	390	Target Neighborhood Hits	1305	Shared Neighborhood Hits	144
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NGEF_HUMAN
θ value	θ > 10 (rank : 715)	NC score	0.080407 (rank : 393)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.081850 (rank : 376)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NIN_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.091361 (rank : 292)
Query Neighborhood Hits	390	Target Neighborhood Hits	1416	Shared Neighborhood Hits	160
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 718)	NC score	0.105404 (rank : 222)
Query Neighborhood Hits	390	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NTBP1_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.056237 (rank : 729)
Query Neighborhood Hits	390	Target Neighborhood Hits	528	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

NUF2_HUMAN
θ value	θ > 10 (rank : 720)	NC score	0.067802 (rank : 590)
Query Neighborhood Hits	390	Target Neighborhood Hits	661	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

NUF2_MOUSE
θ value	θ > 10 (rank : 721)	NC score	0.069595 (rank : 559)
Query Neighborhood Hits	390	Target Neighborhood Hits	585	Shared Neighborhood Hits	123
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

NUMA1_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.085916 (rank : 330)
Query Neighborhood Hits	390	Target Neighborhood Hits	1523	Shared Neighborhood Hits	161
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

OFD1_HUMAN
θ value	θ > 10 (rank : 723)	NC score	0.071932 (rank : 523)
Query Neighborhood Hits	390	Target Neighborhood Hits	753	Shared Neighborhood Hits	127
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

OPTN_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.072534 (rank : 516)
Query Neighborhood Hits	390	Target Neighborhood Hits	827	Shared Neighborhood Hits	123
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OPTN_MOUSE
θ value	θ > 10 (rank : 725)	NC score	0.085937 (rank : 329)
Query Neighborhood Hits	390	Target Neighborhood Hits	1120	Shared Neighborhood Hits	154
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

P55G_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.118413 (rank : 187)
Query Neighborhood Hits	390	Target Neighborhood Hits	451	Shared Neighborhood Hits	126
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.113639 (rank : 196)
Query Neighborhood Hits	390	Target Neighborhood Hits	401	Shared Neighborhood Hits	117
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.163233 (rank : 161)
Query Neighborhood Hits	390	Target Neighborhood Hits	543	Shared Neighborhood Hits	166
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.143229 (rank : 179)
Query Neighborhood Hits	390	Target Neighborhood Hits	519	Shared Neighborhood Hits	157
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCNT_MOUSE
θ value	θ > 10 (rank : 730)	NC score	0.079435 (rank : 408)
Query Neighborhood Hits	390	Target Neighborhood Hits	1207	Shared Neighborhood Hits	149
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PCTL_HUMAN
θ value	θ > 10 (rank : 731)	NC score	0.050727 (rank : 816)
Query Neighborhood Hits	390	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 732)	NC score	0.051331 (rank : 798)
Query Neighborhood Hits	390	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 733)	NC score	0.051040 (rank : 808)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PEPL_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.074536 (rank : 485)
Query Neighborhood Hits	390	Target Neighborhood Hits	1141	Shared Neighborhood Hits	140
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEX13_HUMAN
θ value	θ > 10 (rank : 735)	NC score	0.112626 (rank : 200)
Query Neighborhood Hits	390	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 736)	NC score	0.111189 (rank : 205)
Query Neighborhood Hits	390	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PHLB2_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.082282 (rank : 367)
Query Neighborhood Hits	390	Target Neighborhood Hits	964	Shared Neighborhood Hits	141
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.078075 (rank : 427)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	140
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PIBF1_HUMAN
θ value	θ > 10 (rank : 739)	NC score	0.099116 (rank : 244)
Query Neighborhood Hits	390	Target Neighborhood Hits	1041	Shared Neighborhood Hits	150
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PININ_HUMAN
θ value	θ > 10 (rank : 740)	NC score	0.056159 (rank : 731)
Query Neighborhood Hits	390	Target Neighborhood Hits	753	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PININ_MOUSE
θ value	θ > 10 (rank : 741)	NC score	0.053470 (rank : 763)
Query Neighborhood Hits	390	Target Neighborhood Hits	777	Shared Neighborhood Hits	101
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PKHG1_HUMAN
θ value	θ > 10 (rank : 742)	NC score	0.075117 (rank : 476)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PLCB4_HUMAN
θ value	θ > 10 (rank : 743)	NC score	0.051296 (rank : 801)
Query Neighborhood Hits	390	Target Neighborhood Hits	658	Shared Neighborhood Hits	111
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLVAP_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.057318 (rank : 721)
Query Neighborhood Hits	390	Target Neighborhood Hits	397	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

POF1B_HUMAN
θ value	θ > 10 (rank : 745)	NC score	0.066180 (rank : 617)
Query Neighborhood Hits	390	Target Neighborhood Hits	494	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

POF1B_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.066240 (rank : 616)
Query Neighborhood Hits	390	Target Neighborhood Hits	530	Shared Neighborhood Hits	107
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

PPIP2_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.071208 (rank : 537)
Query Neighborhood Hits	390	Target Neighborhood Hits	254	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.071985 (rank : 522)
Query Neighborhood Hits	390	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 749)	NC score	0.081906 (rank : 374)
Query Neighborhood Hits	390	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTN11_HUMAN
θ value	θ > 10 (rank : 750)	NC score	0.051849 (rank : 785)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 751)	NC score	0.051857 (rank : 784)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RABE2_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.057851 (rank : 714)
Query Neighborhood Hits	390	Target Neighborhood Hits	545	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RABE2_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.070725 (rank : 543)
Query Neighborhood Hits	390	Target Neighborhood Hits	598	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RAD50_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.092391 (rank : 281)
Query Neighborhood Hits	390	Target Neighborhood Hits	1317	Shared Neighborhood Hits	154
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	θ > 10 (rank : 755)	NC score	0.091178 (rank : 294)
Query Neighborhood Hits	390	Target Neighborhood Hits	1366	Shared Neighborhood Hits	164
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RASA1_HUMAN
θ value	θ > 10 (rank : 756)	NC score	0.100428 (rank : 241)
Query Neighborhood Hits	390	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF8_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.055317 (rank : 743)
Query Neighborhood Hits	390	Target Neighborhood Hits	469	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

RASF8_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.051410 (rank : 796)
Query Neighborhood Hits	390	Target Neighborhood Hits	391	Shared Neighborhood Hits	89
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

RB6I2_HUMAN
θ value	θ > 10 (rank : 759)	NC score	0.083940 (rank : 348)
Query Neighborhood Hits	390	Target Neighborhood Hits	1584	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	θ > 10 (rank : 760)	NC score	0.081463 (rank : 381)
Query Neighborhood Hits	390	Target Neighborhood Hits	1433	Shared Neighborhood Hits	159
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RBBP8_HUMAN
θ value	θ > 10 (rank : 761)	NC score	0.054154 (rank : 756)
Query Neighborhood Hits	390	Target Neighborhood Hits	476	Shared Neighborhood Hits	89
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RBCC1_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.075455 (rank : 462)
Query Neighborhood Hits	390	Target Neighborhood Hits	1023	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RBCC1_MOUSE
θ value	θ > 10 (rank : 763)	NC score	0.081893 (rank : 375)
Query Neighborhood Hits	390	Target Neighborhood Hits	1048	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RBM25_HUMAN
θ value	θ > 10 (rank : 764)	NC score	0.058920 (rank : 703)
Query Neighborhood Hits	390	Target Neighborhood Hits	682	Shared Neighborhood Hits	104
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RFIP4_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.077543 (rank : 441)
Query Neighborhood Hits	390	Target Neighborhood Hits	785	Shared Neighborhood Hits	133
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RFIP4_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.071900 (rank : 526)
Query Neighborhood Hits	390	Target Neighborhood Hits	708	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RGNEF_MOUSE
θ value	θ > 10 (rank : 767)	NC score	0.075248 (rank : 473)
Query Neighborhood Hits	390	Target Neighborhood Hits	641	Shared Neighborhood Hits	105
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RIMB2_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.105077 (rank : 225)
Query Neighborhood Hits	390	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.116014 (rank : 190)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	101
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ROCK1_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.051804 (rank : 787)
Query Neighborhood Hits	390	Target Neighborhood Hits	2000	Shared Neighborhood Hits	184
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 771)	NC score	0.055242 (rank : 744)
Query Neighborhood Hits	390	Target Neighborhood Hits	2126	Shared Neighborhood Hits	190
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RPGR1_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.066123 (rank : 618)
Query Neighborhood Hits	390	Target Neighborhood Hits	578	Shared Neighborhood Hits	102
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RPGR1_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.061103 (rank : 683)
Query Neighborhood Hits	390	Target Neighborhood Hits	713	Shared Neighborhood Hits	92
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RRBP1_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.077570 (rank : 440)
Query Neighborhood Hits	390	Target Neighborhood Hits	1306	Shared Neighborhood Hits	144
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RUFY1_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.062716 (rank : 665)
Query Neighborhood Hits	390	Target Neighborhood Hits	848	Shared Neighborhood Hits	127
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 776)	NC score	0.057598 (rank : 715)
Query Neighborhood Hits	390	Target Neighborhood Hits	765	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	θ > 10 (rank : 777)	NC score	0.075446 (rank : 466)
Query Neighborhood Hits	390	Target Neighborhood Hits	1208	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	θ > 10 (rank : 778)	NC score	0.067845 (rank : 589)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY3_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.067183 (rank : 598)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	125
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 780)	NC score	0.064391 (rank : 640)
Query Neighborhood Hits	390	Target Neighborhood Hits	579	Shared Neighborhood Hits	121
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUSC2_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.066658 (rank : 607)
Query Neighborhood Hits	390	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SAS6_HUMAN
θ value	θ > 10 (rank : 782)	NC score	0.078520 (rank : 418)
Query Neighborhood Hits	390	Target Neighborhood Hits	791	Shared Neighborhood Hits	126
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SAS6_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.082238 (rank : 368)
Query Neighborhood Hits	390	Target Neighborhood Hits	931	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SDCG8_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.082674 (rank : 360)
Query Neighborhood Hits	390	Target Neighborhood Hits	1002	Shared Neighborhood Hits	138
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SDCG8_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.079852 (rank : 400)
Query Neighborhood Hits	390	Target Neighborhood Hits	886	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SEC20_MOUSE
θ value	θ > 10 (rank : 786)	NC score	0.057350 (rank : 718)
Query Neighborhood Hits	390	Target Neighborhood Hits	323	Shared Neighborhood Hits	90
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

SH21A_HUMAN
θ value	θ > 10 (rank : 787)	NC score	0.079870 (rank : 399)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 788)	NC score	0.080151 (rank : 396)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.077343 (rank : 443)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 790)	NC score	0.085824 (rank : 332)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 791)	NC score	0.069604 (rank : 558)
Query Neighborhood Hits	390	Target Neighborhood Hits	455	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 792)	NC score	0.051909 (rank : 783)
Query Neighborhood Hits	390	Target Neighborhood Hits	326	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.051232 (rank : 803)
Query Neighborhood Hits	390	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.054020 (rank : 760)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN1_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.060886 (rank : 686)
Query Neighborhood Hits	390	Target Neighborhood Hits	1041	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 796)	NC score	0.075838 (rank : 458)
Query Neighborhood Hits	390	Target Neighborhood Hits	446	Shared Neighborhood Hits	101
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.073849 (rank : 497)
Query Neighborhood Hits	390	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 798)	NC score	0.075358 (rank : 468)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 799)	NC score	0.070151 (rank : 549)
Query Neighborhood Hits	390	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 800)	NC score	0.072865 (rank : 511)
Query Neighborhood Hits	390	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.068715 (rank : 581)
Query Neighborhood Hits	390	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.069994 (rank : 552)
Query Neighborhood Hits	390	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.063971 (rank : 645)
Query Neighborhood Hits	390	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.067213 (rank : 597)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.063272 (rank : 656)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 806)	NC score	0.069924 (rank : 554)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.067159 (rank : 599)
Query Neighborhood Hits	390	Target Neighborhood Hits	164	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.068672 (rank : 582)
Query Neighborhood Hits	390	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.073025 (rank : 509)
Query Neighborhood Hits	390	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 810)	NC score	0.074704 (rank : 481)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.074095 (rank : 492)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.075449 (rank : 464)
Query Neighborhood Hits	390	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SKIL_MOUSE
θ value	θ > 10 (rank : 813)	NC score	0.055852 (rank : 734)
Query Neighborhood Hits	390	Target Neighborhood Hits	719	Shared Neighborhood Hits	124
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SLAP1_HUMAN
θ value	θ > 10 (rank : 814)	NC score	0.115408 (rank : 191)
Query Neighborhood Hits	390	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.116032 (rank : 189)
Query Neighborhood Hits	390	Target Neighborhood Hits	117	Shared Neighborhood Hits	49
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.121218 (rank : 186)
Query Neighborhood Hits	390	Target Neighborhood Hits	139	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.127527 (rank : 183)
Query Neighborhood Hits	390	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_MOUSE
θ value	θ > 10 (rank : 818)	NC score	0.054324 (rank : 754)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SM1L2_HUMAN
θ value	θ > 10 (rank : 819)	NC score	0.078048 (rank : 430)
Query Neighborhood Hits	390	Target Neighborhood Hits	1019	Shared Neighborhood Hits	148
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SM1L2_MOUSE
θ value	θ > 10 (rank : 820)	NC score	0.080152 (rank : 395)
Query Neighborhood Hits	390	Target Neighborhood Hits	918	Shared Neighborhood Hits	148
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SMC1A_HUMAN
θ value	θ > 10 (rank : 821)	NC score	0.079227 (rank : 411)
Query Neighborhood Hits	390	Target Neighborhood Hits	1346	Shared Neighborhood Hits	159
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	θ > 10 (rank : 822)	NC score	0.080060 (rank : 398)
Query Neighborhood Hits	390	Target Neighborhood Hits	1384	Shared Neighborhood Hits	163
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SMC2_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.081285 (rank : 383)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	164
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SMC2_MOUSE
θ value	θ > 10 (rank : 824)	NC score	0.071333 (rank : 534)
Query Neighborhood Hits	390	Target Neighborhood Hits	1131	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC3_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.078225 (rank : 425)
Query Neighborhood Hits	390	Target Neighborhood Hits	1186	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.078434 (rank : 421)
Query Neighborhood Hits	390	Target Neighborhood Hits	1187	Shared Neighborhood Hits	152
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC4_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.069321 (rank : 567)
Query Neighborhood Hits	390	Target Neighborhood Hits	830	Shared Neighborhood Hits	130
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SNX18_HUMAN
θ value	θ > 10 (rank : 828)	NC score	0.108437 (rank : 212)
Query Neighborhood Hits	390	Target Neighborhood Hits	207	Shared Neighborhood Hits	104
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 829)	NC score	0.110913 (rank : 207)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX23_HUMAN
θ value	θ > 10 (rank : 830)	NC score	0.051074 (rank : 806)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	131
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

SNX9_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.071726 (rank : 528)
Query Neighborhood Hits	390	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 832)	NC score	0.062248 (rank : 672)
Query Neighborhood Hits	390	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPAG5_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.073201 (rank : 506)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	120
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

SPAG5_MOUSE
θ value	θ > 10 (rank : 834)	NC score	0.063974 (rank : 644)
Query Neighborhood Hits	390	Target Neighborhood Hits	612	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SPC24_HUMAN
θ value	θ > 10 (rank : 835)	NC score	0.065172 (rank : 630)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

SPN90_HUMAN
θ value	θ > 10 (rank : 836)	NC score	0.125243 (rank : 184)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 837)	NC score	0.104617 (rank : 227)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTB1_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.050071 (rank : 826)
Query Neighborhood Hits	390	Target Neighborhood Hits	543	Shared Neighborhood Hits	103
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SPTB2_HUMAN
θ value	θ > 10 (rank : 839)	NC score	0.068806 (rank : 578)
Query Neighborhood Hits	390	Target Neighborhood Hits	748	Shared Neighborhood Hits	124
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	θ > 10 (rank : 840)	NC score	0.074005 (rank : 494)
Query Neighborhood Hits	390	Target Neighborhood Hits	770	Shared Neighborhood Hits	126
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN5_HUMAN
θ value	θ > 10 (rank : 841)	NC score	0.053023 (rank : 769)
Query Neighborhood Hits	390	Target Neighborhood Hits	674	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SRMS_MOUSE
θ value	θ > 10 (rank : 842)	NC score	0.052531 (rank : 775)
Query Neighborhood Hits	390	Target Neighborhood Hits	964	Shared Neighborhood Hits	99
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC3_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.215344 (rank : 140)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	137
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 844)	NC score	0.221721 (rank : 134)
Query Neighborhood Hits	390	Target Neighborhood Hits	232	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STIM1_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.057319 (rank : 720)
Query Neighborhood Hits	390	Target Neighborhood Hits	665	Shared Neighborhood Hits	117
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.055613 (rank : 741)
Query Neighborhood Hits	390	Target Neighborhood Hits	660	Shared Neighborhood Hits	114
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STS1_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.054552 (rank : 753)
Query Neighborhood Hits	390	Target Neighborhood Hits	106	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 848)	NC score	0.054973 (rank : 748)
Query Neighborhood Hits	390	Target Neighborhood Hits	104	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.060972 (rank : 684)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

STXB4_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.050202 (rank : 823)
Query Neighborhood Hits	390	Target Neighborhood Hits	616	Shared Neighborhood Hits	103
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SWP70_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.080433 (rank : 392)
Query Neighborhood Hits	390	Target Neighborhood Hits	973	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 852)	NC score	0.078453 (rank : 420)
Query Neighborhood Hits	390	Target Neighborhood Hits	1097	Shared Neighborhood Hits	146
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.091080 (rank : 295)
Query Neighborhood Hits	390	Target Neighborhood Hits	1313	Shared Neighborhood Hits	159
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE1_HUMAN
θ value	θ > 10 (rank : 854)	NC score	0.078228 (rank : 424)
Query Neighborhood Hits	390	Target Neighborhood Hits	1484	Shared Neighborhood Hits	165
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYNE2_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.069336 (rank : 566)
Query Neighborhood Hits	390	Target Neighborhood Hits	1323	Shared Neighborhood Hits	154
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T3JAM_HUMAN
θ value	θ > 10 (rank : 856)	NC score	0.071232 (rank : 536)
Query Neighborhood Hits	390	Target Neighborhood Hits	533	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

T3JAM_MOUSE
θ value	θ > 10 (rank : 857)	NC score	0.056822 (rank : 725)
Query Neighborhood Hits	390	Target Neighborhood Hits	535	Shared Neighborhood Hits	99
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TACC1_HUMAN
θ value	θ > 10 (rank : 858)	NC score	0.052006 (rank : 780)
Query Neighborhood Hits	390	Target Neighborhood Hits	597	Shared Neighborhood Hits	107
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TACC1_MOUSE
θ value	θ > 10 (rank : 859)	NC score	0.055625 (rank : 740)
Query Neighborhood Hits	390	Target Neighborhood Hits	667	Shared Neighborhood Hits	111
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TACC2_HUMAN
θ value	θ > 10 (rank : 860)	NC score	0.075453 (rank : 463)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	138
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
θ value	θ > 10 (rank : 861)	NC score	0.060494 (rank : 690)
Query Neighborhood Hits	390	Target Neighborhood Hits	774	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TACC3_HUMAN
θ value	θ > 10 (rank : 862)	NC score	0.062211 (rank : 673)
Query Neighborhood Hits	390	Target Neighborhood Hits	779	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TACC3_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.062787 (rank : 663)
Query Neighborhood Hits	390	Target Neighborhood Hits	607	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

TARA_MOUSE
θ value	θ > 10 (rank : 864)	NC score	0.052062 (rank : 779)
Query Neighborhood Hits	390	Target Neighborhood Hits	1133	Shared Neighborhood Hits	125
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TAXB1_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.087745 (rank : 313)
Query Neighborhood Hits	390	Target Neighborhood Hits	829	Shared Neighborhood Hits	129
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TAXB1_MOUSE
θ value	θ > 10 (rank : 866)	NC score	0.092765 (rank : 274)
Query Neighborhood Hits	390	Target Neighborhood Hits	886	Shared Neighborhood Hits	141
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TCRG1_HUMAN
θ value	θ > 10 (rank : 867)	NC score	0.084386 (rank : 342)
Query Neighborhood Hits	390	Target Neighborhood Hits	929	Shared Neighborhood Hits	118
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 868)	NC score	0.085216 (rank : 337)
Query Neighborhood Hits	390	Target Neighborhood Hits	947	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TEKT1_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.051995 (rank : 781)
Query Neighborhood Hits	390	Target Neighborhood Hits	289	Shared Neighborhood Hits	89
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

TEKT1_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.058785 (rank : 707)
Query Neighborhood Hits	390	Target Neighborhood Hits	399	Shared Neighborhood Hits	102
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

TEX9_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.064652 (rank : 637)
Query Neighborhood Hits	390	Target Neighborhood Hits	541	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TEX9_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.066801 (rank : 605)
Query Neighborhood Hits	390	Target Neighborhood Hits	581	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TIAM1_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.076570 (rank : 450)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.075396 (rank : 467)
Query Neighborhood Hits	390	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TMF1_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.077299 (rank : 445)
Query Neighborhood Hits	390	Target Neighborhood Hits	987	Shared Neighborhood Hits	128
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TPM1_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.066571 (rank : 609)
Query Neighborhood Hits	390	Target Neighborhood Hits	716	Shared Neighborhood Hits	124
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	θ > 10 (rank : 877)	NC score	0.066403 (rank : 612)
Query Neighborhood Hits	390	Target Neighborhood Hits	729	Shared Neighborhood Hits	125
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM2_HUMAN
θ value	θ > 10 (rank : 878)	NC score	0.064459 (rank : 639)
Query Neighborhood Hits	390	Target Neighborhood Hits	677	Shared Neighborhood Hits	114
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
θ value	θ > 10 (rank : 879)	NC score	0.063586 (rank : 648)
Query Neighborhood Hits	390	Target Neighborhood Hits	676	Shared Neighborhood Hits	116
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM3_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.065666 (rank : 622)
Query Neighborhood Hits	390	Target Neighborhood Hits	689	Shared Neighborhood Hits	118
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	θ > 10 (rank : 881)	NC score	0.065662 (rank : 623)
Query Neighborhood Hits	390	Target Neighborhood Hits	676	Shared Neighborhood Hits	118
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TPM4_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.062534 (rank : 667)
Query Neighborhood Hits	390	Target Neighborhood Hits	525	Shared Neighborhood Hits	107
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

TPM4_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.065865 (rank : 620)
Query Neighborhood Hits	390	Target Neighborhood Hits	703	Shared Neighborhood Hits	121
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

TRAIP_HUMAN
θ value	θ > 10 (rank : 884)	NC score	0.069968 (rank : 553)
Query Neighborhood Hits	390	Target Neighborhood Hits	780	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAIP_MOUSE
θ value	θ > 10 (rank : 885)	NC score	0.073570 (rank : 501)
Query Neighborhood Hits	390	Target Neighborhood Hits	745	Shared Neighborhood Hits	121
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRAK1_HUMAN
θ value	θ > 10 (rank : 886)	NC score	0.075267 (rank : 472)
Query Neighborhood Hits	390	Target Neighborhood Hits	660	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

TRAK2_HUMAN
θ value	θ > 10 (rank : 887)	NC score	0.058885 (rank : 704)
Query Neighborhood Hits	390	Target Neighborhood Hits	476	Shared Neighborhood Hits	98
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

TSC1_HUMAN
θ value	θ > 10 (rank : 888)	NC score	0.078694 (rank : 414)
Query Neighborhood Hits	390	Target Neighborhood Hits	765	Shared Neighborhood Hits	125
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TUFT1_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.073126 (rank : 507)
Query Neighborhood Hits	390	Target Neighborhood Hits	686	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TUFT1_MOUSE
θ value	θ > 10 (rank : 890)	NC score	0.078909 (rank : 413)
Query Neighborhood Hits	390	Target Neighborhood Hits	732	Shared Neighborhood Hits	135
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

TXLNB_MOUSE
θ value	θ > 10 (rank : 891)	NC score	0.062033 (rank : 676)
Query Neighborhood Hits	390	Target Neighborhood Hits	640	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

UN13A_HUMAN
θ value	θ > 10 (rank : 892)	NC score	0.055663 (rank : 739)
Query Neighborhood Hits	390	Target Neighborhood Hits	285	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 893)	NC score	0.053110 (rank : 767)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	30
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UTRO_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.068091 (rank : 586)
Query Neighborhood Hits	390	Target Neighborhood Hits	960	Shared Neighborhood Hits	133
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

VDP_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.065034 (rank : 631)
Query Neighborhood Hits	390	Target Neighborhood Hits	645	Shared Neighborhood Hits	116
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

WDR67_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.063851 (rank : 646)
Query Neighborhood Hits	390	Target Neighborhood Hits	782	Shared Neighborhood Hits	114
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

XE7_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.070395 (rank : 547)
Query Neighborhood Hits	390	Target Neighborhood Hits	738	Shared Neighborhood Hits	116
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

ZN291_HUMAN
θ value	θ > 10 (rank : 898)	NC score	0.070938 (rank : 540)
Query Neighborhood Hits	390	Target Neighborhood Hits	647	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

ZWINT_HUMAN
θ value	θ > 10 (rank : 899)	NC score	0.051785 (rank : 789)
Query Neighborhood Hits	390	Target Neighborhood Hits	333	Shared Neighborhood Hits	82
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

ZWINT_MOUSE
θ value	θ > 10 (rank : 900)	NC score	0.067451 (rank : 594)
Query Neighborhood Hits	390	Target Neighborhood Hits	497	Shared Neighborhood Hits	106
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

Hits sorted by NC score

SRGP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	390	Target Neighborhood Hits	390	Shared Neighborhood Hits	390
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
NC score	0.974120 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	244
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.973188 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	390	Target Neighborhood Hits	331	Shared Neighborhood Hits	240
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
NC score	0.961333 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	390	Target Neighborhood Hits	432	Shared Neighborhood Hits	271
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG04_HUMAN
NC score	0.947787 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	209
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG09_HUMAN
NC score	0.727598 (rank : 6)	θ value	2.20605e-14 (rank : 30)
Query Neighborhood Hits	390	Target Neighborhood Hits	186	Shared Neighborhood Hits	99
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_MOUSE
NC score	0.711701 (rank : 7)	θ value	4.58923e-20 (rank : 11)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	105
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_HUMAN
NC score	0.710152 (rank : 8)	θ value	5.60996e-18 (rank : 15)
Query Neighborhood Hits	390	Target Neighborhood Hits	190	Shared Neighborhood Hits	101
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

3BP1_MOUSE
NC score	0.699357 (rank : 9)	θ value	7.58209e-15 (rank : 29)
Query Neighborhood Hits	390	Target Neighborhood Hits	238	Shared Neighborhood Hits	78
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TCGAP_MOUSE
NC score	0.698897 (rank : 10)	θ value	4.02038e-16 (rank : 23)
Query Neighborhood Hits	390	Target Neighborhood Hits	409	Shared Neighborhood Hits	156
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

3BP1_HUMAN
NC score	0.691157 (rank : 11)	θ value	5.25075e-16 (rank : 24)
Query Neighborhood Hits	390	Target Neighborhood Hits	376	Shared Neighborhood Hits	92
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GMIP_MOUSE
NC score	0.691063 (rank : 12)	θ value	1.16975e-15 (rank : 26)
Query Neighborhood Hits	390	Target Neighborhood Hits	202	Shared Neighborhood Hits	88
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG06_HUMAN
NC score	0.688818 (rank : 13)	θ value	3.18553e-13 (rank : 34)
Query Neighborhood Hits	390	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.688093 (rank : 14)	θ value	1.86753e-13 (rank : 32)
Query Neighborhood Hits	390	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

GRLF1_HUMAN
NC score	0.687666 (rank : 15)	θ value	1.86321e-21 (rank : 10)
Query Neighborhood Hits	390	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

CHIO_MOUSE
NC score	0.687599 (rank : 16)	θ value	6.18819e-25 (rank : 6)
Query Neighborhood Hits	390	Target Neighborhood Hits	130	Shared Neighborhood Hits	71
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GMIP_HUMAN
NC score	0.684420 (rank : 17)	θ value	1.52774e-15 (rank : 27)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG01_HUMAN
NC score	0.680639 (rank : 18)	θ value	3.07829e-16 (rank : 20)
Query Neighborhood Hits	390	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

CHIN_MOUSE
NC score	0.676814 (rank : 19)	θ value	8.93572e-24 (rank : 9)
Query Neighborhood Hits	390	Target Neighborhood Hits	229	Shared Neighborhood Hits	101
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.673897 (rank : 20)	θ value	1.37858e-24 (rank : 7)
Query Neighborhood Hits	390	Target Neighborhood Hits	220	Shared Neighborhood Hits	97
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.673169 (rank : 21)	θ value	8.93572e-24 (rank : 8)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	96
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG26_HUMAN
NC score	0.670984 (rank : 22)	θ value	2.98157e-11 (rank : 42)
Query Neighborhood Hits	390	Target Neighborhood Hits	281	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG08_HUMAN
NC score	0.667999 (rank : 23)	θ value	5.25075e-16 (rank : 25)
Query Neighborhood Hits	390	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG05_MOUSE
NC score	0.667969 (rank : 24)	θ value	3.28887e-18 (rank : 14)
Query Neighborhood Hits	390	Target Neighborhood Hits	165	Shared Neighborhood Hits	88
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG08_MOUSE
NC score	0.665941 (rank : 25)	θ value	5.8054e-15 (rank : 28)
Query Neighborhood Hits	390	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

OPHN1_HUMAN
NC score	0.662729 (rank : 26)	θ value	2.7842e-17 (rank : 18)
Query Neighborhood Hits	390	Target Neighborhood Hits	161	Shared Neighborhood Hits	82
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
NC score	0.659870 (rank : 27)	θ value	3.63628e-17 (rank : 19)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	84
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RGAP1_MOUSE
NC score	0.658841 (rank : 28)	θ value	1.133e-10 (rank : 44)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	86
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGAP1_HUMAN
NC score	0.657779 (rank : 29)	θ value	2.52405e-10 (rank : 47)
Query Neighborhood Hits	390	Target Neighborhood Hits	189	Shared Neighborhood Hits	96
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG25_MOUSE
NC score	0.656268 (rank : 30)	θ value	2.5182e-18 (rank : 13)
Query Neighborhood Hits	390	Target Neighborhood Hits	492	Shared Neighborhood Hits	133
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG05_HUMAN
NC score	0.653801 (rank : 31)	θ value	3.07829e-16 (rank : 21)
Query Neighborhood Hits	390	Target Neighborhood Hits	158	Shared Neighborhood Hits	82
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

BCR_HUMAN
NC score	0.647592 (rank : 32)	θ value	5.99374e-20 (rank : 12)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	81
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.647221 (rank : 33)	θ value	7.32683e-18 (rank : 16)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	80
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RBP1_MOUSE
NC score	0.643381 (rank : 34)	θ value	1.09485e-13 (rank : 31)
Query Neighborhood Hits	390	Target Neighborhood Hits	493	Shared Neighborhood Hits	146
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_HUMAN
NC score	0.642288 (rank : 35)	θ value	7.32683e-18 (rank : 17)
Query Neighborhood Hits	390	Target Neighborhood Hits	550	Shared Neighborhood Hits	152
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TAGAP_HUMAN
NC score	0.635336 (rank : 36)	θ value	8.67504e-11 (rank : 43)
Query Neighborhood Hits	390	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.633659 (rank : 37)	θ value	1.25267e-09 (rank : 48)
Query Neighborhood Hits	390	Target Neighborhood Hits	83	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RBP1_HUMAN
NC score	0.627868 (rank : 38)	θ value	3.18553e-13 (rank : 33)
Query Neighborhood Hits	390	Target Neighborhood Hits	521	Shared Neighborhood Hits	148
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

TCGAP_HUMAN
NC score	0.621832 (rank : 39)	θ value	4.02038e-16 (rank : 22)
Query Neighborhood Hits	390	Target Neighborhood Hits	872	Shared Neighborhood Hits	165
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RHG18_HUMAN
NC score	0.610653 (rank : 40)	θ value	3.77169e-06 (rank : 61)
Query Neighborhood Hits	390	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG18_MOUSE
NC score	0.600771 (rank : 41)	θ value	2.44474e-05 (rank : 66)
Query Neighborhood Hits	390	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG07_MOUSE
NC score	0.591168 (rank : 42)	θ value	2.69671e-12 (rank : 39)
Query Neighborhood Hits	390	Target Neighborhood Hits	103	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.581351 (rank : 43)	θ value	1.133e-10 (rank : 45)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	65
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

STA13_HUMAN
NC score	0.561773 (rank : 44)	θ value	5.43371e-13 (rank : 36)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
NC score	0.552167 (rank : 45)	θ value	7.84624e-12 (rank : 41)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAR8_MOUSE
NC score	0.549651 (rank : 46)	θ value	1.63604e-09 (rank : 49)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STAR8_HUMAN
NC score	0.542021 (rank : 47)	θ value	2.13673e-09 (rank : 50)
Query Neighborhood Hits	390	Target Neighborhood Hits	216	Shared Neighborhood Hits	63
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

CEND2_HUMAN
NC score	0.534674 (rank : 48)	θ value	5.43371e-13 (rank : 35)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CE005_HUMAN
NC score	0.531022 (rank : 49)	θ value	1.69304e-06 (rank : 59)
Query Neighborhood Hits	390	Target Neighborhood Hits	213	Shared Neighborhood Hits	97
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.530706 (rank : 50)	θ value	1.29631e-06 (rank : 56)
Query Neighborhood Hits	390	Target Neighborhood Hits	238	Shared Neighborhood Hits	99
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

K1688_MOUSE
NC score	0.492864 (rank : 51)	θ value	7.59969e-07 (rank : 54)
Query Neighborhood Hits	390	Target Neighborhood Hits	188	Shared Neighborhood Hits	69
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

CEND3_MOUSE
NC score	0.490862 (rank : 52)	θ value	8.11959e-09 (rank : 51)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CEND3_HUMAN
NC score	0.481066 (rank : 53)	θ value	4.0297e-08 (rank : 53)
Query Neighborhood Hits	390	Target Neighborhood Hits	275	Shared Neighborhood Hits	70
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

K1688_HUMAN
NC score	0.478420 (rank : 54)	θ value	9.92553e-07 (rank : 55)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	71
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

CEND1_MOUSE
NC score	0.460482 (rank : 55)	θ value	2.69671e-12 (rank : 38)
Query Neighborhood Hits	390	Target Neighborhood Hits	260	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.440696 (rank : 56)	θ value	1.47974e-10 (rank : 46)
Query Neighborhood Hits	390	Target Neighborhood Hits	284	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

MYO9B_MOUSE
NC score	0.386504 (rank : 57)	θ value	4.59992e-12 (rank : 40)
Query Neighborhood Hits	390	Target Neighborhood Hits	311	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P85A_MOUSE
NC score	0.385334 (rank : 58)	θ value	0.00035302 (rank : 91)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	184
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_HUMAN
NC score	0.381384 (rank : 59)	θ value	1.2105e-12 (rank : 37)
Query Neighborhood Hits	390	Target Neighborhood Hits	641	Shared Neighborhood Hits	110
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P85A_HUMAN
NC score	0.379861 (rank : 60)	θ value	0.00298849 (rank : 109)
Query Neighborhood Hits	390	Target Neighborhood Hits	479	Shared Neighborhood Hits	194
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

NCF4_MOUSE
NC score	0.332736 (rank : 61)	θ value	8.40245e-06 (rank : 62)
Query Neighborhood Hits	390	Target Neighborhood Hits	177	Shared Neighborhood Hits	118
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

VINEX_MOUSE
NC score	0.331675 (rank : 62)	θ value	5.44631e-05 (rank : 74)
Query Neighborhood Hits	390	Target Neighborhood Hits	286	Shared Neighborhood Hits	151
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCK2_HUMAN
NC score	0.330834 (rank : 63)	θ value	1.43324e-05 (rank : 65)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SRBS1_HUMAN
NC score	0.327533 (rank : 64)	θ value	2.44474e-05 (rank : 67)
Query Neighborhood Hits	390	Target Neighborhood Hits	396	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.327107 (rank : 65)	θ value	0.00020696 (rank : 88)
Query Neighborhood Hits	390	Target Neighborhood Hits	270	Shared Neighborhood Hits	147
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

I5P2_HUMAN
NC score	0.326870 (rank : 66)	θ value	0.000121331 (rank : 83)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

SRBS1_MOUSE
NC score	0.323901 (rank : 67)	θ value	4.1701e-05 (rank : 70)
Query Neighborhood Hits	390	Target Neighborhood Hits	409	Shared Neighborhood Hits	152
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NPHP1_MOUSE
NC score	0.317161 (rank : 68)	θ value	3.19293e-05 (rank : 68)
Query Neighborhood Hits	390	Target Neighborhood Hits	267	Shared Neighborhood Hits	162
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

GRB2_HUMAN
NC score	0.316039 (rank : 69)	θ value	9.29e-05 (rank : 77)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	155
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.315726 (rank : 70)	θ value	9.29e-05 (rank : 78)
Query Neighborhood Hits	390	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF4_HUMAN
NC score	0.314072 (rank : 71)	θ value	0.000121331 (rank : 84)
Query Neighborhood Hits	390	Target Neighborhood Hits	161	Shared Neighborhood Hits	110
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3K1_MOUSE
NC score	0.311762 (rank : 72)	θ value	0.000121331 (rank : 86)
Query Neighborhood Hits	390	Target Neighborhood Hits	332	Shared Neighborhood Hits	159
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCK1_HUMAN
NC score	0.310672 (rank : 73)	θ value	0.000121331 (rank : 85)
Query Neighborhood Hits	390	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP_HUMAN
NC score	0.307718 (rank : 74)	θ value	0.00665767 (rank : 117)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	155
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

OCRL_HUMAN
NC score	0.306736 (rank : 75)	θ value	0.00020696 (rank : 87)
Query Neighborhood Hits	390	Target Neighborhood Hits	77	Shared Neighborhood Hits	51
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

ABI2_MOUSE
NC score	0.306559 (rank : 76)	θ value	7.1131e-05 (rank : 75)
Query Neighborhood Hits	390	Target Neighborhood Hits	266	Shared Neighborhood Hits	143
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF2_HUMAN
NC score	0.304562 (rank : 77)	θ value	0.0736092 (rank : 158)
Query Neighborhood Hits	390	Target Neighborhood Hits	229	Shared Neighborhood Hits	132
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI2_HUMAN
NC score	0.303518 (rank : 78)	θ value	9.29e-05 (rank : 76)
Query Neighborhood Hits	390	Target Neighborhood Hits	350	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

HCLS1_HUMAN
NC score	0.300606 (rank : 79)	θ value	0.00134147 (rank : 100)
Query Neighborhood Hits	390	Target Neighborhood Hits	358	Shared Neighborhood Hits	146
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP_MOUSE
NC score	0.300261 (rank : 80)	θ value	0.0330416 (rank : 140)
Query Neighborhood Hits	390	Target Neighborhood Hits	309	Shared Neighborhood Hits	155
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SH3K1_HUMAN
NC score	0.300143 (rank : 81)	θ value	0.00102713 (rank : 99)
Query Neighborhood Hits	390	Target Neighborhood Hits	341	Shared Neighborhood Hits	159
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CIP4_HUMAN
NC score	0.299925 (rank : 82)	θ value	1.06045e-08 (rank : 52)
Query Neighborhood Hits	390	Target Neighborhood Hits	374	Shared Neighborhood Hits	141
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

HCLS1_MOUSE
NC score	0.299228 (rank : 83)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	390	Target Neighborhood Hits	329	Shared Neighborhood Hits	143
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

CD2AP_HUMAN
NC score	0.298865 (rank : 84)	θ value	0.0330416 (rank : 139)
Query Neighborhood Hits	390	Target Neighborhood Hits	315	Shared Neighborhood Hits	166
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NPHP1_HUMAN
NC score	0.295714 (rank : 85)	θ value	5.44631e-05 (rank : 72)
Query Neighborhood Hits	390	Target Neighborhood Hits	288	Shared Neighborhood Hits	153
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

CRKL_HUMAN
NC score	0.293858 (rank : 86)	θ value	0.000121331 (rank : 81)
Query Neighborhood Hits	390	Target Neighborhood Hits	313	Shared Neighborhood Hits	153
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.282385 (rank : 87)	θ value	0.00035302 (rank : 90)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	152
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABI1_MOUSE
NC score	0.281012 (rank : 88)	θ value	0.00390308 (rank : 111)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	139
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CD2AP_MOUSE
NC score	0.277650 (rank : 89)	θ value	1.38821 (rank : 268)
Query Neighborhood Hits	390	Target Neighborhood Hits	336	Shared Neighborhood Hits	161
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GRAP2_HUMAN
NC score	0.270493 (rank : 90)	θ value	0.0431538 (rank : 147)
Query Neighborhood Hits	390	Target Neighborhood Hits	304	Shared Neighborhood Hits	152
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CRK_HUMAN
NC score	0.268766 (rank : 91)	θ value	0.0148317 (rank : 131)
Query Neighborhood Hits	390	Target Neighborhood Hits	308	Shared Neighborhood Hits	147
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.268519 (rank : 92)	θ value	0.0148317 (rank : 132)
Query Neighborhood Hits	390	Target Neighborhood Hits	314	Shared Neighborhood Hits	147
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRAP2_MOUSE
NC score	0.267267 (rank : 93)	θ value	0.163984 (rank : 186)
Query Neighborhood Hits	390	Target Neighborhood Hits	297	Shared Neighborhood Hits	152
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ITSN2_HUMAN
NC score	0.266984 (rank : 94)	θ value	2.88788e-06 (rank : 60)
Query Neighborhood Hits	390	Target Neighborhood Hits	1173	Shared Neighborhood Hits	262
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ABI1_HUMAN
NC score	0.265687 (rank : 95)	θ value	0.0148317 (rank : 129)
Query Neighborhood Hits	390	Target Neighborhood Hits	257	Shared Neighborhood Hits	141
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ARHG7_MOUSE
NC score	0.265079 (rank : 96)	θ value	0.00228821 (rank : 104)
Query Neighborhood Hits	390	Target Neighborhood Hits	396	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN2_MOUSE
NC score	0.264237 (rank : 97)	θ value	1.29631e-06 (rank : 58)
Query Neighborhood Hits	390	Target Neighborhood Hits	1371	Shared Neighborhood Hits	275
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PPIP1_HUMAN
NC score	0.260418 (rank : 98)	θ value	0.62314 (rank : 240)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	199
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SRC8_MOUSE
NC score	0.259017 (rank : 99)	θ value	0.125558 (rank : 177)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	150
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC_HUMAN
NC score	0.257581 (rank : 100)	θ value	0.163984 (rank : 191)
Query Neighborhood Hits	390	Target Neighborhood Hits	276	Shared Neighborhood Hits	142
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ITSN1_HUMAN
NC score	0.256093 (rank : 101)	θ value	1.29631e-06 (rank : 57)
Query Neighborhood Hits	390	Target Neighborhood Hits	1757	Shared Neighborhood Hits	284
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

STAC_MOUSE
NC score	0.255127 (rank : 102)	θ value	0.125558 (rank : 178)
Query Neighborhood Hits	390	Target Neighborhood Hits	268	Shared Neighborhood Hits	141
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PPIP1_MOUSE
NC score	0.254922 (rank : 103)	θ value	0.21417 (rank : 203)
Query Neighborhood Hits	390	Target Neighborhood Hits	377	Shared Neighborhood Hits	195
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SRC8_HUMAN
NC score	0.251869 (rank : 104)	θ value	0.47712 (rank : 231)
Query Neighborhood Hits	390	Target Neighborhood Hits	269	Shared Neighborhood Hits	149
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

ITSN1_MOUSE
NC score	0.251089 (rank : 105)	θ value	4.1701e-05 (rank : 69)
Query Neighborhood Hits	390	Target Neighborhood Hits	1669	Shared Neighborhood Hits	279
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SH3G2_HUMAN
NC score	0.250226 (rank : 106)	θ value	0.0431538 (rank : 148)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

VAV3_HUMAN
NC score	0.248298 (rank : 107)	θ value	0.000786445 (rank : 97)
Query Neighborhood Hits	390	Target Neighborhood Hits	398	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.245185 (rank : 108)	θ value	0.000602161 (rank : 93)
Query Neighborhood Hits	390	Target Neighborhood Hits	404	Shared Neighborhood Hits	151
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_HUMAN
NC score	0.244414 (rank : 109)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	390	Target Neighborhood Hits	453	Shared Neighborhood Hits	149
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

DNMBP_HUMAN
NC score	0.244298 (rank : 110)	θ value	0.279714 (rank : 210)
Query Neighborhood Hits	390	Target Neighborhood Hits	413	Shared Neighborhood Hits	173
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV2_MOUSE
NC score	0.243789 (rank : 111)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	390	Target Neighborhood Hits	456	Shared Neighborhood Hits	149
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PACN2_HUMAN
NC score	0.242910 (rank : 112)	θ value	0.0148317 (rank : 133)
Query Neighborhood Hits	390	Target Neighborhood Hits	339	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_MOUSE
NC score	0.241507 (rank : 113)	θ value	0.0961366 (rank : 165)
Query Neighborhood Hits	390	Target Neighborhood Hits	319	Shared Neighborhood Hits	164
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ARHG7_HUMAN
NC score	0.241460 (rank : 114)	θ value	0.0431538 (rank : 143)
Query Neighborhood Hits	390	Target Neighborhood Hits	347	Shared Neighborhood Hits	156
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SH3G1_MOUSE
NC score	0.239712 (rank : 115)	θ value	0.0961366 (rank : 164)
Query Neighborhood Hits	390	Target Neighborhood Hits	291	Shared Neighborhood Hits	163
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G3_MOUSE
NC score	0.238178 (rank : 116)	θ value	0.0736092 (rank : 160)
Query Neighborhood Hits	390	Target Neighborhood Hits	236	Shared Neighborhood Hits	148
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_HUMAN
NC score	0.236905 (rank : 117)	θ value	0.21417 (rank : 204)
Query Neighborhood Hits	390	Target Neighborhood Hits	307	Shared Neighborhood Hits	169
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

STAM2_MOUSE
NC score	0.236619 (rank : 118)	θ value	0.62314 (rank : 242)
Query Neighborhood Hits	390	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G3_HUMAN
NC score	0.234839 (rank : 119)	θ value	0.0563607 (rank : 153)
Query Neighborhood Hits	390	Target Neighborhood Hits	222	Shared Neighborhood Hits	141
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

STAM2_HUMAN
NC score	0.234589 (rank : 120)	θ value	0.0330416 (rank : 142)
Query Neighborhood Hits	390	Target Neighborhood Hits	288	Shared Neighborhood Hits	150
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_MOUSE
NC score	0.233806 (rank : 121)	θ value	0.279714 (rank : 217)
Query Neighborhood Hits	390	Target Neighborhood Hits	273	Shared Neighborhood Hits	145
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN2_MOUSE
NC score	0.233024 (rank : 122)	θ value	0.125558 (rank : 174)
Query Neighborhood Hits	390	Target Neighborhood Hits	382	Shared Neighborhood Hits	178
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAM1_HUMAN
NC score	0.232636 (rank : 123)	θ value	0.365318 (rank : 224)
Query Neighborhood Hits	390	Target Neighborhood Hits	271	Shared Neighborhood Hits	147
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

DNMBP_MOUSE
NC score	0.230006 (rank : 124)	θ value	0.365318 (rank : 222)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	162
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV_MOUSE
NC score	0.228061 (rank : 125)	θ value	0.163984 (rank : 192)
Query Neighborhood Hits	390	Target Neighborhood Hits	430	Shared Neighborhood Hits	148
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG6_MOUSE
NC score	0.227162 (rank : 126)	θ value	0.365318 (rank : 220)
Query Neighborhood Hits	390	Target Neighborhood Hits	394	Shared Neighborhood Hits	178
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ABI3_MOUSE
NC score	0.226717 (rank : 127)	θ value	1.81305 (rank : 280)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN1_HUMAN
NC score	0.225988 (rank : 128)	θ value	0.125558 (rank : 173)
Query Neighborhood Hits	390	Target Neighborhood Hits	320	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

VAV_HUMAN
NC score	0.225786 (rank : 129)	θ value	0.21417 (rank : 207)
Query Neighborhood Hits	390	Target Neighborhood Hits	452	Shared Neighborhood Hits	153
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PACN1_MOUSE
NC score	0.225612 (rank : 130)	θ value	0.0961366 (rank : 162)
Query Neighborhood Hits	390	Target Neighborhood Hits	283	Shared Neighborhood Hits	156
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

OSTF1_HUMAN
NC score	0.224469 (rank : 131)	θ value	0.0563607 (rank : 152)
Query Neighborhood Hits	390	Target Neighborhood Hits	466	Shared Neighborhood Hits	151
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ABI3_HUMAN
NC score	0.224091 (rank : 132)	θ value	1.38821 (rank : 266)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCF1_MOUSE
NC score	0.222173 (rank : 133)	θ value	0.813845 (rank : 246)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	132
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

STAC3_MOUSE
NC score	0.221721 (rank : 134)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	390	Target Neighborhood Hits	232	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PACN3_MOUSE
NC score	0.220487 (rank : 135)	θ value	0.21417 (rank : 202)
Query Neighborhood Hits	390	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ARHG6_HUMAN
NC score	0.220457 (rank : 136)	θ value	0.47712 (rank : 225)
Query Neighborhood Hits	390	Target Neighborhood Hits	376	Shared Neighborhood Hits	170
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PACN3_HUMAN
NC score	0.218398 (rank : 137)	θ value	0.21417 (rank : 201)
Query Neighborhood Hits	390	Target Neighborhood Hits	385	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ANM2_MOUSE
NC score	0.216782 (rank : 138)	θ value	1.09739e-05 (rank : 63)
Query Neighborhood Hits	390	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_HUMAN
NC score	0.216680 (rank : 139)	θ value	0.000270298 (rank : 89)
Query Neighborhood Hits	390	Target Neighborhood Hits	175	Shared Neighborhood Hits	129
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

STAC3_HUMAN
NC score	0.215344 (rank : 140)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	137
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

OSTF1_MOUSE
NC score	0.215085 (rank : 141)	θ value	0.125558 (rank : 172)
Query Neighborhood Hits	390	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ARHG9_MOUSE
NC score	0.202955 (rank : 142)	θ value	0.0113563 (rank : 125)
Query Neighborhood Hits	390	Target Neighborhood Hits	234	Shared Neighborhood Hits	133
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.201769 (rank : 143)	θ value	0.0113563 (rank : 124)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	132
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

NCF1_HUMAN
NC score	0.198036 (rank : 144)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	128
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SPTA2_HUMAN
NC score	0.196790 (rank : 145)	θ value	5.44631e-05 (rank : 73)
Query Neighborhood Hits	390	Target Neighborhood Hits	888	Shared Neighborhood Hits	245
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

AHI1_MOUSE
NC score	0.195530 (rank : 146)	θ value	0.0330416 (rank : 138)
Query Neighborhood Hits	390	Target Neighborhood Hits	496	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG4_HUMAN
NC score	0.195412 (rank : 147)	θ value	0.163984 (rank : 180)
Query Neighborhood Hits	390	Target Neighborhood Hits	242	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

AHI1_HUMAN
NC score	0.194679 (rank : 148)	θ value	0.0961366 (rank : 161)
Query Neighborhood Hits	390	Target Neighborhood Hits	537	Shared Neighborhood Hits	148
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SPTA1_HUMAN
NC score	0.179742 (rank : 149)	θ value	0.00298849 (rank : 110)
Query Neighborhood Hits	390	Target Neighborhood Hits	748	Shared Neighborhood Hits	236
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RUSC1_HUMAN
NC score	0.177697 (rank : 150)	θ value	1.06291 (rank : 263)
Query Neighborhood Hits	390	Target Neighborhood Hits	226	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

SPTA1_MOUSE
NC score	0.176256 (rank : 151)	θ value	0.00390308 (rank : 114)
Query Neighborhood Hits	390	Target Neighborhood Hits	675	Shared Neighborhood Hits	218
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NEBL_HUMAN
NC score	0.176093 (rank : 152)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	390	Target Neighborhood Hits	457	Shared Neighborhood Hits	182
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

IASPP_HUMAN
NC score	0.175223 (rank : 153)	θ value	0.00298849 (rank : 108)
Query Neighborhood Hits	390	Target Neighborhood Hits	688	Shared Neighborhood Hits	139
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BCAR1_MOUSE
NC score	0.174004 (rank : 154)	θ value	2.36792 (rank : 295)
Query Neighborhood Hits	390	Target Neighborhood Hits	438	Shared Neighborhood Hits	143
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PLCG1_MOUSE
NC score	0.171025 (rank : 155)	θ value	5.27518 (rank : 345)
Query Neighborhood Hits	390	Target Neighborhood Hits	314	Shared Neighborhood Hits	140
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MYO1F_MOUSE
NC score	0.169445 (rank : 156)	θ value	0.00228821 (rank : 105)
Query Neighborhood Hits	390	Target Neighborhood Hits	262	Shared Neighborhood Hits	157
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.168364 (rank : 157)	θ value	0.00509761 (rank : 116)
Query Neighborhood Hits	390	Target Neighborhood Hits	275	Shared Neighborhood Hits	157
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

RUSC1_MOUSE
NC score	0.168248 (rank : 158)	θ value	0.62314 (rank : 241)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

PLCG2_HUMAN
NC score	0.164687 (rank : 159)	θ value	4.03905 (rank : 330)
Query Neighborhood Hits	390	Target Neighborhood Hits	280	Shared Neighborhood Hits	134
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.164123 (rank : 160)	θ value	8.99809 (rank : 382)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	138
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

P85B_HUMAN
NC score	0.163233 (rank : 161)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	390	Target Neighborhood Hits	543	Shared Neighborhood Hits	166
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

NOXO1_MOUSE
NC score	0.162821 (rank : 162)	θ value	0.813845 (rank : 247)
Query Neighborhood Hits	390	Target Neighborhood Hits	114	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

EFS_HUMAN
NC score	0.162146 (rank : 163)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	390	Target Neighborhood Hits	348	Shared Neighborhood Hits	131
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NEBU_HUMAN
NC score	0.161558 (rank : 164)	θ value	0.47712 (rank : 230)
Query Neighborhood Hits	390	Target Neighborhood Hits	420	Shared Neighborhood Hits	161
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

EFS_MOUSE
NC score	0.159731 (rank : 165)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

IASPP_MOUSE
NC score	0.159369 (rank : 166)	θ value	0.0113563 (rank : 126)
Query Neighborhood Hits	390	Target Neighborhood Hits	1024	Shared Neighborhood Hits	149
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DBNL_HUMAN
NC score	0.157993 (rank : 167)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	390	Target Neighborhood Hits	244	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ASPP1_HUMAN
NC score	0.156975 (rank : 168)	θ value	0.279714 (rank : 208)
Query Neighborhood Hits	390	Target Neighborhood Hits	956	Shared Neighborhood Hits	210
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
NC score	0.156295 (rank : 169)	θ value	6.88961 (rank : 353)
Query Neighborhood Hits	390	Target Neighborhood Hits	554	Shared Neighborhood Hits	143
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

MYO1E_HUMAN
NC score	0.155972 (rank : 170)	θ value	1.38821 (rank : 272)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	157
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

LASP1_HUMAN
NC score	0.155789 (rank : 171)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	390	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.155251 (rank : 172)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	390	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DBNL_MOUSE
NC score	0.154422 (rank : 173)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	390	Target Neighborhood Hits	306	Shared Neighborhood Hits	140
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ASPP1_MOUSE
NC score	0.149471 (rank : 174)	θ value	1.06291 (rank : 255)
Query Neighborhood Hits	390	Target Neighborhood Hits	1244	Shared Neighborhood Hits	219
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
NC score	0.145923 (rank : 175)	θ value	0.163984 (rank : 181)
Query Neighborhood Hits	390	Target Neighborhood Hits	1156	Shared Neighborhood Hits	227
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

RIMB1_MOUSE
NC score	0.145923 (rank : 176)	θ value	0.813845 (rank : 253)
Query Neighborhood Hits	390	Target Neighborhood Hits	1376	Shared Neighborhood Hits	248
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ARHG4_MOUSE
NC score	0.143894 (rank : 177)	θ value	8.99809 (rank : 369)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	100
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CT032_HUMAN
NC score	0.143779 (rank : 178)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

P85B_MOUSE
NC score	0.143229 (rank : 179)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	390	Target Neighborhood Hits	519	Shared Neighborhood Hits	157
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CASL_HUMAN
NC score	0.143041 (rank : 180)	θ value	0.279714 (rank : 209)
Query Neighborhood Hits	390	Target Neighborhood Hits	259	Shared Neighborhood Hits	129
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.138074 (rank : 181)	θ value	3.0926 (rank : 307)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	122
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

RIMB1_HUMAN
NC score	0.131834 (rank : 182)	θ value	6.88961 (rank : 364)
Query Neighborhood Hits	390	Target Neighborhood Hits	1479	Shared Neighborhood Hits	233
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SLAP2_MOUSE
NC score	0.127527 (rank : 183)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	390	Target Neighborhood Hits	136	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_HUMAN
NC score	0.125243 (rank : 184)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

CCD46_HUMAN
NC score	0.124417 (rank : 185)	θ value	1.09739e-05 (rank : 64)
Query Neighborhood Hits	390	Target Neighborhood Hits	1430	Shared Neighborhood Hits	169
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

SLAP2_HUMAN
NC score	0.121218 (rank : 186)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	390	Target Neighborhood Hits	139	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

P55G_HUMAN
NC score	0.118413 (rank : 187)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	390	Target Neighborhood Hits	451	Shared Neighborhood Hits	126
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CCD46_MOUSE
NC score	0.116946 (rank : 188)	θ value	0.000461057 (rank : 92)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	171
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

SLAP1_MOUSE
NC score	0.116032 (rank : 189)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	390	Target Neighborhood Hits	117	Shared Neighborhood Hits	49
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

RIMB2_MOUSE
NC score	0.116014 (rank : 190)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	101
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SLAP1_HUMAN
NC score	0.115408 (rank : 191)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	390	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

MYH3_HUMAN
NC score	0.114799 (rank : 192)	θ value	1.06291 (rank : 260)
Query Neighborhood Hits	390	Target Neighborhood Hits	1660	Shared Neighborhood Hits	180
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MY18A_HUMAN
NC score	0.114439 (rank : 193)	θ value	0.0113563 (rank : 127)
Query Neighborhood Hits	390	Target Neighborhood Hits	1929	Shared Neighborhood Hits	193
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

DDEF1_MOUSE
NC score	0.114169 (rank : 194)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	390	Target Neighborhood Hits	592	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ES8L3_MOUSE
NC score	0.113829 (rank : 195)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	390	Target Neighborhood Hits	168	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

P55G_MOUSE
NC score	0.113639 (rank : 196)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	390	Target Neighborhood Hits	401	Shared Neighborhood Hits	117
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MYH8_HUMAN
NC score	0.112808 (rank : 197)	θ value	0.163984 (rank : 188)
Query Neighborhood Hits	390	Target Neighborhood Hits	1610	Shared Neighborhood Hits	182
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

DAPP1_MOUSE
NC score	0.112703 (rank : 198)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF2_HUMAN
NC score	0.112627 (rank : 199)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	390	Target Neighborhood Hits	599	Shared Neighborhood Hits	151
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PEX13_HUMAN
NC score	0.112626 (rank : 200)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	390	Target Neighborhood Hits	128	Shared Neighborhood Hits	91
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

DAPP1_HUMAN
NC score	0.112502 (rank : 201)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

YES_MOUSE
NC score	0.112130 (rank : 202)	θ value	4.1701e-05 (rank : 71)
Query Neighborhood Hits	390	Target Neighborhood Hits	1052	Shared Neighborhood Hits	169
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

LIPA1_HUMAN
NC score	0.111999 (rank : 203)	θ value	9.29e-05 (rank : 79)
Query Neighborhood Hits	390	Target Neighborhood Hits	1294	Shared Neighborhood Hits	162
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

DDEF2_MOUSE
NC score	0.111659 (rank : 204)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	148
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PEX13_MOUSE
NC score	0.111189 (rank : 205)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	390	Target Neighborhood Hits	126	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

MYH8_MOUSE
NC score	0.111145 (rank : 206)	θ value	0.163984 (rank : 189)
Query Neighborhood Hits	390	Target Neighborhood Hits	1600	Shared Neighborhood Hits	178
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SNX18_MOUSE
NC score	0.110913 (rank : 207)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

YES_HUMAN
NC score	0.110374 (rank : 208)	θ value	9.29e-05 (rank : 80)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	169
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

MY18A_MOUSE
NC score	0.109315 (rank : 209)	θ value	0.62314 (rank : 238)
Query Neighborhood Hits	390	Target Neighborhood Hits	1989	Shared Neighborhood Hits	193
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

FGR_HUMAN
NC score	0.109295 (rank : 210)	θ value	0.00298849 (rank : 106)
Query Neighborhood Hits	390	Target Neighborhood Hits	1067	Shared Neighborhood Hits	163
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

LIPA2_MOUSE
NC score	0.108710 (rank : 211)	θ value	0.00102713 (rank : 98)
Query Neighborhood Hits	390	Target Neighborhood Hits	1282	Shared Neighborhood Hits	160
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

SNX18_HUMAN
NC score	0.108437 (rank : 212)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	390	Target Neighborhood Hits	207	Shared Neighborhood Hits	104
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

MYH1_MOUSE
NC score	0.108339 (rank : 213)	θ value	0.21417 (rank : 198)
Query Neighborhood Hits	390	Target Neighborhood Hits	1461	Shared Neighborhood Hits	180
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

FYN_MOUSE
NC score	0.107515 (rank : 214)	θ value	0.00175202 (rank : 102)
Query Neighborhood Hits	390	Target Neighborhood Hits	1073	Shared Neighborhood Hits	164
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FGR_MOUSE
NC score	0.106805 (rank : 215)	θ value	0.00298849 (rank : 107)
Query Neighborhood Hits	390	Target Neighborhood Hits	1069	Shared Neighborhood Hits	165
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MYH1_HUMAN
NC score	0.106770 (rank : 216)	θ value	0.163984 (rank : 187)
Query Neighborhood Hits	390	Target Neighborhood Hits	1478	Shared Neighborhood Hits	173
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH4_HUMAN
NC score	0.106134 (rank : 217)	θ value	0.0736092 (rank : 157)
Query Neighborhood Hits	390	Target Neighborhood Hits	1377	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

SRC_HUMAN
NC score	0.105855 (rank : 218)	θ value	0.00175202 (rank : 103)
Query Neighborhood Hits	390	Target Neighborhood Hits	1058	Shared Neighborhood Hits	166
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

MYH10_MOUSE
NC score	0.105643 (rank : 219)	θ value	0.62314 (rank : 239)
Query Neighborhood Hits	390	Target Neighborhood Hits	1612	Shared Neighborhood Hits	175
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CEP63_HUMAN
NC score	0.105478 (rank : 220)	θ value	0.813845 (rank : 243)
Query Neighborhood Hits	390	Target Neighborhood Hits	1005	Shared Neighborhood Hits	145
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

MYH9_MOUSE
NC score	0.105448 (rank : 221)	θ value	0.125558 (rank : 171)
Query Neighborhood Hits	390	Target Neighborhood Hits	1829	Shared Neighborhood Hits	179
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NOXO1_HUMAN
NC score	0.105404 (rank : 222)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	390	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

FYN_HUMAN
NC score	0.105280 (rank : 223)	θ value	0.00175202 (rank : 101)
Query Neighborhood Hits	390	Target Neighborhood Hits	1078	Shared Neighborhood Hits	165
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

MYH9_HUMAN
NC score	0.105133 (rank : 224)	θ value	1.81305 (rank : 290)
Query Neighborhood Hits	390	Target Neighborhood Hits	1762	Shared Neighborhood Hits	181
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RIMB2_HUMAN
NC score	0.105077 (rank : 225)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	390	Target Neighborhood Hits	263	Shared Neighborhood Hits	107
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L3_HUMAN
NC score	0.104903 (rank : 226)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SPN90_MOUSE
NC score	0.104617 (rank : 227)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	78
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

MYH10_HUMAN
NC score	0.104317 (rank : 228)	θ value	1.06291 (rank : 259)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	174
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

TNIP3_HUMAN
NC score	0.103826 (rank : 229)	θ value	0.0563607 (rank : 154)
Query Neighborhood Hits	390	Target Neighborhood Hits	511	Shared Neighborhood Hits	110
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

MYH11_HUMAN
NC score	0.103737 (rank : 230)	θ value	6.88961 (rank : 363)
Query Neighborhood Hits	390	Target Neighborhood Hits	1806	Shared Neighborhood Hits	182
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.103680 (rank : 231)	θ value	5.27518 (rank : 342)
Query Neighborhood Hits	390	Target Neighborhood Hits	1777	Shared Neighborhood Hits	181
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH4_MOUSE
NC score	0.103608 (rank : 232)	θ value	0.21417 (rank : 199)
Query Neighborhood Hits	390	Target Neighborhood Hits	1476	Shared Neighborhood Hits	177
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH6_MOUSE
NC score	0.103235 (rank : 233)	θ value	0.279714 (rank : 216)
Query Neighborhood Hits	390	Target Neighborhood Hits	1501	Shared Neighborhood Hits	169
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CENPF_HUMAN
NC score	0.102781 (rank : 234)	θ value	0.163984 (rank : 182)
Query Neighborhood Hits	390	Target Neighborhood Hits	1932	Shared Neighborhood Hits	187
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MYO5C_HUMAN
NC score	0.101979 (rank : 235)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	390	Target Neighborhood Hits	1206	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYH2_HUMAN
NC score	0.101741 (rank : 236)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	390	Target Neighborhood Hits	1491	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

GOGB1_HUMAN
NC score	0.101439 (rank : 237)	θ value	6.88961 (rank : 359)
Query Neighborhood Hits	390	Target Neighborhood Hits	2297	Shared Neighborhood Hits	192
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

CE152_HUMAN
NC score	0.101321 (rank : 238)	θ value	8.99809 (rank : 370)
Query Neighborhood Hits	390	Target Neighborhood Hits	976	Shared Neighborhood Hits	143
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

EPS8_MOUSE
NC score	0.101257 (rank : 239)	θ value	0.125558 (rank : 169)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	102
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

DLG5_HUMAN
NC score	0.100660 (rank : 240)	θ value	0.21417 (rank : 195)
Query Neighborhood Hits	390	Target Neighborhood Hits	1088	Shared Neighborhood Hits	168
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

RASA1_HUMAN
NC score	0.100428 (rank : 241)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	390	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

GOGA5_MOUSE
NC score	0.100383 (rank : 242)	θ value	0.47712 (rank : 226)
Query Neighborhood Hits	390	Target Neighborhood Hits	1434	Shared Neighborhood Hits	164
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

MYH6_HUMAN
NC score	0.099774 (rank : 243)	θ value	1.06291 (rank : 261)
Query Neighborhood Hits	390	Target Neighborhood Hits	1426	Shared Neighborhood Hits	166
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PIBF1_HUMAN
NC score	0.099116 (rank : 244)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	390	Target Neighborhood Hits	1041	Shared Neighborhood Hits	150
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

CI093_HUMAN
NC score	0.098776 (rank : 245)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	390	Target Neighborhood Hits	1088	Shared Neighborhood Hits	153
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

MYH7_HUMAN
NC score	0.098437 (rank : 246)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	390	Target Neighborhood Hits	1559	Shared Neighborhood Hits	170
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH13_HUMAN
NC score	0.098251 (rank : 247)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	390	Target Neighborhood Hits	1504	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

ES8L1_MOUSE
NC score	0.098224 (rank : 248)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	390	Target Neighborhood Hits	143	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

TPR_HUMAN
NC score	0.098207 (rank : 249)	θ value	4.03905 (rank : 334)
Query Neighborhood Hits	390	Target Neighborhood Hits	1921	Shared Neighborhood Hits	167
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

MY18B_HUMAN
NC score	0.098133 (rank : 250)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	390	Target Neighborhood Hits	1299	Shared Neighborhood Hits	155
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYO10_HUMAN
NC score	0.097956 (rank : 251)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	390	Target Neighborhood Hits	920	Shared Neighborhood Hits	133
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NAF1_MOUSE
NC score	0.097816 (rank : 252)	θ value	0.0330416 (rank : 141)
Query Neighborhood Hits	390	Target Neighborhood Hits	852	Shared Neighborhood Hits	132
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

EEA1_HUMAN
NC score	0.097579 (rank : 253)	θ value	4.03905 (rank : 324)
Query Neighborhood Hits	390	Target Neighborhood Hits	1796	Shared Neighborhood Hits	172
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

REST_MOUSE
NC score	0.097137 (rank : 254)	θ value	0.0193708 (rank : 135)
Query Neighborhood Hits	390	Target Neighborhood Hits	1506	Shared Neighborhood Hits	163
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

GOGA3_MOUSE
NC score	0.097135 (rank : 255)	θ value	0.163984 (rank : 184)
Query Neighborhood Hits	390	Target Neighborhood Hits	1437	Shared Neighborhood Hits	159
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA4_HUMAN
NC score	0.096845 (rank : 256)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	390	Target Neighborhood Hits	2034	Shared Neighborhood Hits	186
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CR034_HUMAN
NC score	0.096842 (rank : 257)	θ value	0.125558 (rank : 168)
Query Neighborhood Hits	390	Target Neighborhood Hits	538	Shared Neighborhood Hits	109
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

LIPA2_HUMAN
NC score	0.096566 (rank : 258)	θ value	0.47712 (rank : 229)
Query Neighborhood Hits	390	Target Neighborhood Hits	1044	Shared Neighborhood Hits	145
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

GOGA4_MOUSE
NC score	0.096425 (rank : 259)	θ value	0.0252991 (rank : 136)
Query Neighborhood Hits	390	Target Neighborhood Hits	1939	Shared Neighborhood Hits	183
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

NAF1_HUMAN
NC score	0.096276 (rank : 260)	θ value	0.21417 (rank : 200)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	139
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

REST_HUMAN
NC score	0.095869 (rank : 261)	θ value	0.813845 (rank : 252)
Query Neighborhood Hits	390	Target Neighborhood Hits	1605	Shared Neighborhood Hits	169
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

CE290_HUMAN
NC score	0.094934 (rank : 262)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	390	Target Neighborhood Hits	1553	Shared Neighborhood Hits	167
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

GOGA6_HUMAN
NC score	0.094894 (rank : 263)	θ value	0.163984 (rank : 185)
Query Neighborhood Hits	390	Target Neighborhood Hits	1007	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GCC2_HUMAN
NC score	0.094882 (rank : 264)	θ value	8.99809 (rank : 375)
Query Neighborhood Hits	390	Target Neighborhood Hits	1558	Shared Neighborhood Hits	176
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.094749 (rank : 265)	θ value	8.99809 (rank : 385)
Query Neighborhood Hits	390	Target Neighborhood Hits	1559	Shared Neighborhood Hits	177
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RFIP3_HUMAN
NC score	0.094676 (rank : 266)	θ value	0.0736092 (rank : 159)
Query Neighborhood Hits	390	Target Neighborhood Hits	1055	Shared Neighborhood Hits	137
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

MYH14_MOUSE
NC score	0.094269 (rank : 267)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	390	Target Neighborhood Hits	1225	Shared Neighborhood Hits	152
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

BTK_HUMAN
NC score	0.094257 (rank : 268)	θ value	0.0148317 (rank : 130)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	161
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CP250_HUMAN
NC score	0.093936 (rank : 269)	θ value	0.163984 (rank : 183)
Query Neighborhood Hits	390	Target Neighborhood Hits	1805	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CYLN2_MOUSE
NC score	0.093752 (rank : 270)	θ value	6.88961 (rank : 357)
Query Neighborhood Hits	390	Target Neighborhood Hits	1002	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

GCC2_MOUSE
NC score	0.093691 (rank : 271)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	390	Target Neighborhood Hits	1619	Shared Neighborhood Hits	169
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

CI039_HUMAN
NC score	0.093212 (rank : 272)	θ value	0.21417 (rank : 194)
Query Neighborhood Hits	390	Target Neighborhood Hits	1171	Shared Neighborhood Hits	151
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

ES8L2_HUMAN
NC score	0.093191 (rank : 273)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	390	Target Neighborhood Hits	193	Shared Neighborhood Hits	108
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

TAXB1_MOUSE
NC score	0.092765 (rank : 274)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	390	Target Neighborhood Hits	886	Shared Neighborhood Hits	141
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

GAS8_HUMAN
NC score	0.092702 (rank : 275)	θ value	6.88961 (rank : 358)
Query Neighborhood Hits	390	Target Neighborhood Hits	819	Shared Neighborhood Hits	137
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

RABE1_HUMAN
NC score	0.092641 (rank : 276)	θ value	0.813845 (rank : 251)
Query Neighborhood Hits	390	Target Neighborhood Hits	1104	Shared Neighborhood Hits	153
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

BTK_MOUSE
NC score	0.092588 (rank : 277)	θ value	0.00869519 (rank : 119)
Query Neighborhood Hits	390	Target Neighborhood Hits	1017	Shared Neighborhood Hits	155
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CN145_HUMAN
NC score	0.092584 (rank : 278)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	390	Target Neighborhood Hits	1196	Shared Neighborhood Hits	154
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

MYO5A_MOUSE
NC score	0.092544 (rank : 279)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	390	Target Neighborhood Hits	1117	Shared Neighborhood Hits	148
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

GOGA5_HUMAN
NC score	0.092450 (rank : 280)	θ value	0.62314 (rank : 235)
Query Neighborhood Hits	390	Target Neighborhood Hits	1168	Shared Neighborhood Hits	149
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

RAD50_HUMAN
NC score	0.092391 (rank : 281)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	390	Target Neighborhood Hits	1317	Shared Neighborhood Hits	154
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

TRIPB_HUMAN
NC score	0.092379 (rank : 282)	θ value	0.813845 (rank : 254)
Query Neighborhood Hits	390	Target Neighborhood Hits	1587	Shared Neighborhood Hits	170
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

AKAP9_HUMAN
NC score	0.092376 (rank : 283)	θ value	1.81305 (rank : 281)
Query Neighborhood Hits	390	Target Neighborhood Hits	1710	Shared Neighborhood Hits	171
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GAS7_HUMAN
NC score	0.092320 (rank : 284)	θ value	1.81305 (rank : 284)
Query Neighborhood Hits	390	Target Neighborhood Hits	258	Shared Neighborhood Hits	74
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SYCP1_MOUSE
NC score	0.092275 (rank : 285)	θ value	0.21417 (rank : 206)
Query Neighborhood Hits	390	Target Neighborhood Hits	1456	Shared Neighborhood Hits	165
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

MYO5A_HUMAN
NC score	0.092263 (rank : 286)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	390	Target Neighborhood Hits	1092	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

RABE1_MOUSE
NC score	0.092020 (rank : 287)	θ value	1.38821 (rank : 274)
Query Neighborhood Hits	390	Target Neighborhood Hits	1105	Shared Neighborhood Hits	153
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

CYLN2_HUMAN
NC score	0.091986 (rank : 288)	θ value	2.36792 (rank : 296)
Query Neighborhood Hits	390	Target Neighborhood Hits	1004	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

HMMR_MOUSE
NC score	0.091819 (rank : 289)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	390	Target Neighborhood Hits	1178	Shared Neighborhood Hits	151
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

RUSC2_HUMAN
NC score	0.091674 (rank : 290)	θ value	1.06291 (rank : 264)
Query Neighborhood Hits	390	Target Neighborhood Hits	205	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CCD39_MOUSE
NC score	0.091638 (rank : 291)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	145
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

NIN_HUMAN
NC score	0.091361 (rank : 292)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	390	Target Neighborhood Hits	1416	Shared Neighborhood Hits	160
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

GAS8_MOUSE
NC score	0.091343 (rank : 293)	θ value	0.813845 (rank : 245)
Query Neighborhood Hits	390	Target Neighborhood Hits	622	Shared Neighborhood Hits	125
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

RAD50_MOUSE
NC score	0.091178 (rank : 294)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	390	Target Neighborhood Hits	1366	Shared Neighborhood Hits	164
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SYCP1_HUMAN
NC score	0.091080 (rank : 295)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	390	Target Neighborhood Hits	1313	Shared Neighborhood Hits	159
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

IFT74_MOUSE
NC score	0.090769 (rank : 296)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	390	Target Neighborhood Hits	939	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT74_HUMAN
NC score	0.090726 (rank : 297)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	390	Target Neighborhood Hits	949	Shared Neighborhood Hits	149
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

HOOK3_HUMAN
NC score	0.090365 (rank : 298)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	390	Target Neighborhood Hits	1070	Shared Neighborhood Hits	158
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

MYH14_HUMAN
NC score	0.089363 (rank : 299)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	390	Target Neighborhood Hits	995	Shared Neighborhood Hits	130
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CASP_MOUSE
NC score	0.089145 (rank : 300)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	390	Target Neighborhood Hits	1152	Shared Neighborhood Hits	154
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CR034_MOUSE
NC score	0.089113 (rank : 301)	θ value	5.27518 (rank : 338)
Query Neighborhood Hits	390	Target Neighborhood Hits	643	Shared Neighborhood Hits	122
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

EEA1_MOUSE
NC score	0.088962 (rank : 302)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	390	Target Neighborhood Hits	1637	Shared Neighborhood Hits	164
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MYO5B_HUMAN
NC score	0.088869 (rank : 303)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	390	Target Neighborhood Hits	911	Shared Neighborhood Hits	133
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

FLIP1_HUMAN
NC score	0.088578 (rank : 304)	θ value	1.06291 (rank : 257)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	163
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

SRC_MOUSE
NC score	0.088511 (rank : 305)	θ value	0.0961366 (rank : 166)
Query Neighborhood Hits	390	Target Neighborhood Hits	1033	Shared Neighborhood Hits	154
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

DESP_HUMAN
NC score	0.088290 (rank : 306)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	390	Target Neighborhood Hits	1470	Shared Neighborhood Hits	169
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GOGA1_HUMAN
NC score	0.088175 (rank : 307)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	390	Target Neighborhood Hits	1222	Shared Neighborhood Hits	148
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

PCNT_HUMAN
NC score	0.088160 (rank : 308)	θ value	3.0926 (rank : 313)
Query Neighborhood Hits	390	Target Neighborhood Hits	1551	Shared Neighborhood Hits	166
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

ES8L1_HUMAN
NC score	0.087950 (rank : 309)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	390	Target Neighborhood Hits	162	Shared Neighborhood Hits	93
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CEP55_MOUSE
NC score	0.087929 (rank : 310)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	390	Target Neighborhood Hits	693	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CK5P2_HUMAN
NC score	0.087816 (rank : 311)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	390	Target Neighborhood Hits	1433	Shared Neighborhood Hits	168
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CROCC_HUMAN
NC score	0.087753 (rank : 312)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	390	Target Neighborhood Hits	1409	Shared Neighborhood Hits	154
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

TAXB1_HUMAN
NC score	0.087745 (rank : 313)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	390	Target Neighborhood Hits	829	Shared Neighborhood Hits	129
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

NIN_MOUSE
NC score	0.087632 (rank : 314)	θ value	3.0926 (rank : 311)
Query Neighborhood Hits	390	Target Neighborhood Hits	1376	Shared Neighborhood Hits	159
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

GAS7_MOUSE
NC score	0.087628 (rank : 315)	θ value	0.813845 (rank : 244)
Query Neighborhood Hits	390	Target Neighborhood Hits	259	Shared Neighborhood Hits	75
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

CP135_MOUSE
NC score	0.087387 (rank : 316)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	390	Target Neighborhood Hits	1278	Shared Neighborhood Hits	155
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

IFT81_MOUSE
NC score	0.087267 (rank : 317)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	143
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

AZI1_HUMAN
NC score	0.087175 (rank : 318)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	390	Target Neighborhood Hits	1000	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CP135_HUMAN
NC score	0.087126 (rank : 319)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	390	Target Neighborhood Hits	1290	Shared Neighborhood Hits	162
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

HOOK3_MOUSE
NC score	0.087070 (rank : 320)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	390	Target Neighborhood Hits	1007	Shared Neighborhood Hits	151
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

KTN1_HUMAN
NC score	0.087008 (rank : 321)	θ value	0.279714 (rank : 213)
Query Neighborhood Hits	390	Target Neighborhood Hits	1197	Shared Neighborhood Hits	148
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

CCD41_MOUSE
NC score	0.086824 (rank : 322)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	390	Target Neighborhood Hits	1399	Shared Neighborhood Hits	162
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

KTN1_MOUSE
NC score	0.086728 (rank : 323)	θ value	8.99809 (rank : 377)
Query Neighborhood Hits	390	Target Neighborhood Hits	1324	Shared Neighborhood Hits	158
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

KMHN1_HUMAN
NC score	0.086719 (rank : 324)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	390	Target Neighborhood Hits	950	Shared Neighborhood Hits	146
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

IFT81_HUMAN
NC score	0.086567 (rank : 325)	θ value	0.62314 (rank : 236)
Query Neighborhood Hits	390	Target Neighborhood Hits	893	Shared Neighborhood Hits	142
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

FRK_HUMAN
NC score	0.086330 (rank : 326)	θ value	0.00869519 (rank : 120)
Query Neighborhood Hits	390	Target Neighborhood Hits	1058	Shared Neighborhood Hits	162
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

CING_MOUSE
NC score	0.086314 (rank : 327)	θ value	8.99809 (rank : 371)
Query Neighborhood Hits	390	Target Neighborhood Hits	1432	Shared Neighborhood Hits	162
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

HCK_HUMAN
NC score	0.086225 (rank : 328)	θ value	0.0736092 (rank : 156)
Query Neighborhood Hits	390	Target Neighborhood Hits	1035	Shared Neighborhood Hits	153
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

OPTN_MOUSE
NC score	0.085937 (rank : 329)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	390	Target Neighborhood Hits	1120	Shared Neighborhood Hits	154
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

NUMA1_HUMAN
NC score	0.085916 (rank : 330)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	390	Target Neighborhood Hits	1523	Shared Neighborhood Hits	161
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

GOGA2_MOUSE
NC score	0.085837 (rank : 331)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	140
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

SH21B_MOUSE
NC score	0.085824 (rank : 332)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

NDE1_HUMAN
NC score	0.085709 (rank : 333)	θ value	4.03905 (rank : 328)
Query Neighborhood Hits	390	Target Neighborhood Hits	823	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

GRAP1_HUMAN
NC score	0.085542 (rank : 334)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	136
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

CING_HUMAN
NC score	0.085307 (rank : 335)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	390	Target Neighborhood Hits	1275	Shared Neighborhood Hits	153
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

AZI1_MOUSE
NC score	0.085236 (rank : 336)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	390	Target Neighborhood Hits	990	Shared Neighborhood Hits	145
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

TCRG1_MOUSE
NC score	0.085216 (rank : 337)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	390	Target Neighborhood Hits	947	Shared Neighborhood Hits	118
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

SMC4_HUMAN
NC score	0.085193 (rank : 338)	θ value	0.0431538 (rank : 149)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CP250_MOUSE
NC score	0.085150 (rank : 339)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	390	Target Neighborhood Hits	1583	Shared Neighborhood Hits	165
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

GOGA1_MOUSE
NC score	0.085013 (rank : 340)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	390	Target Neighborhood Hits	994	Shared Neighborhood Hits	145
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

CENPE_HUMAN
NC score	0.084811 (rank : 341)	θ value	0.21417 (rank : 193)
Query Neighborhood Hits	390	Target Neighborhood Hits	2060	Shared Neighborhood Hits	192
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

TCRG1_HUMAN
NC score	0.084386 (rank : 342)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	390	Target Neighborhood Hits	929	Shared Neighborhood Hits	118
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

BICD2_HUMAN
NC score	0.084328 (rank : 343)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	140
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CJ118_MOUSE
NC score	0.084306 (rank : 344)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	390	Target Neighborhood Hits	1132	Shared Neighborhood Hits	139
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CCD13_HUMAN
NC score	0.084167 (rank : 345)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	390	Target Neighborhood Hits	721	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

K0555_HUMAN
NC score	0.084122 (rank : 346)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	390	Target Neighborhood Hits	880	Shared Neighborhood Hits	140
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

CCD41_HUMAN
NC score	0.084031 (rank : 347)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	390	Target Neighborhood Hits	1139	Shared Neighborhood Hits	144
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

RB6I2_HUMAN
NC score	0.083940 (rank : 348)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	390	Target Neighborhood Hits	1584	Shared Neighborhood Hits	164
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

HMMR_HUMAN
NC score	0.083760 (rank : 349)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	390	Target Neighborhood Hits	1082	Shared Neighborhood Hits	142
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

EP15R_HUMAN
NC score	0.083725 (rank : 350)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	390	Target Neighborhood Hits	1083	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

CCD62_HUMAN
NC score	0.083657 (rank : 351)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	390	Target Neighborhood Hits	631	Shared Neighborhood Hits	123
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

GOGA3_HUMAN
NC score	0.083493 (rank : 352)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	390	Target Neighborhood Hits	1317	Shared Neighborhood Hits	151
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MOES_HUMAN
NC score	0.083322 (rank : 353)	θ value	0.00390308 (rank : 113)
Query Neighborhood Hits	390	Target Neighborhood Hits	892	Shared Neighborhood Hits	125
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

HCK_MOUSE
NC score	0.083242 (rank : 354)	θ value	0.47712 (rank : 227)
Query Neighborhood Hits	390	Target Neighborhood Hits	1029	Shared Neighborhood Hits	151
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ES8L2_MOUSE
NC score	0.083197 (rank : 355)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	390	Target Neighborhood Hits	169	Shared Neighborhood Hits	103
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

UACA_MOUSE
NC score	0.082890 (rank : 356)	θ value	3.0926 (rank : 319)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

CF152_HUMAN
NC score	0.082864 (rank : 357)	θ value	5.27518 (rank : 337)
Query Neighborhood Hits	390	Target Neighborhood Hits	704	Shared Neighborhood Hits	122
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

MYO6_HUMAN
NC score	0.082819 (rank : 358)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	390	Target Neighborhood Hits	727	Shared Neighborhood Hits	118
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

CT2NL_HUMAN
NC score	0.082688 (rank : 359)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

SDCG8_HUMAN
NC score	0.082674 (rank : 360)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	390	Target Neighborhood Hits	1002	Shared Neighborhood Hits	138
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

BICD2_MOUSE
NC score	0.082483 (rank : 361)	θ value	6.88961 (rank : 354)
Query Neighborhood Hits	390	Target Neighborhood Hits	864	Shared Neighborhood Hits	141
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

CF060_HUMAN
NC score	0.082400 (rank : 362)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	390	Target Neighborhood Hits	1270	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

MOES_MOUSE
NC score	0.082377 (rank : 363)	θ value	0.00869519 (rank : 121)
Query Neighborhood Hits	390	Target Neighborhood Hits	923	Shared Neighborhood Hits	125
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

FLIP1_MOUSE
NC score	0.082348 (rank : 364)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	390	Target Neighborhood Hits	1176	Shared Neighborhood Hits	150
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

EPS8_HUMAN
NC score	0.082347 (rank : 365)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	91
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERC2_HUMAN
NC score	0.082300 (rank : 366)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	390	Target Neighborhood Hits	1156	Shared Neighborhood Hits	156
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

PHLB2_HUMAN
NC score	0.082282 (rank : 367)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	390	Target Neighborhood Hits	964	Shared Neighborhood Hits	141
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

SAS6_MOUSE
NC score	0.082238 (rank : 368)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	390	Target Neighborhood Hits	931	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

TRHY_HUMAN
NC score	0.082227 (rank : 369)	θ value	2.36792 (rank : 303)
Query Neighborhood Hits	390	Target Neighborhood Hits	1385	Shared Neighborhood Hits	152
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CN145_MOUSE
NC score	0.082052 (rank : 370)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	390	Target Neighborhood Hits	916	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

FER_HUMAN
NC score	0.082043 (rank : 371)	θ value	0.000121331 (rank : 82)
Query Neighborhood Hits	390	Target Neighborhood Hits	1278	Shared Neighborhood Hits	169
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CASP_HUMAN
NC score	0.082010 (rank : 372)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	390	Target Neighborhood Hits	1131	Shared Neighborhood Hits	148
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CROCC_MOUSE
NC score	0.081950 (rank : 373)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	390	Target Neighborhood Hits	1460	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

PREX1_HUMAN
NC score	0.081906 (rank : 374)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	390	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RBCC1_MOUSE
NC score	0.081893 (rank : 375)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	390	Target Neighborhood Hits	1048	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

NGEF_MOUSE
NC score	0.081850 (rank : 376)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	77
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ERC2_MOUSE
NC score	0.081836 (rank : 377)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	390	Target Neighborhood Hits	1166	Shared Neighborhood Hits	158
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

CCD21_HUMAN
NC score	0.081787 (rank : 378)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	390	Target Neighborhood Hits	1228	Shared Neighborhood Hits	156
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

GRAP1_MOUSE
NC score	0.081731 (rank : 379)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	390	Target Neighborhood Hits	1234	Shared Neighborhood Hits	154
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

CCD39_HUMAN
NC score	0.081591 (rank : 380)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	390	Target Neighborhood Hits	868	Shared Neighborhood Hits	134
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

RB6I2_MOUSE
NC score	0.081463 (rank : 381)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	390	Target Neighborhood Hits	1433	Shared Neighborhood Hits	159
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

ARHG5_HUMAN
NC score	0.081462 (rank : 382)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	390	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SMC2_HUMAN
NC score	0.081285 (rank : 383)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	390	Target Neighborhood Hits	1405	Shared Neighborhood Hits	164
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CCD21_MOUSE
NC score	0.081098 (rank : 384)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CARD9_HUMAN
NC score	0.081095 (rank : 385)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	390	Target Neighborhood Hits	602	Shared Neighborhood Hits	124
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

TXK_MOUSE
NC score	0.081056 (rank : 386)	θ value	0.00869519 (rank : 123)
Query Neighborhood Hits	390	Target Neighborhood Hits	980	Shared Neighborhood Hits	128
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

EP15R_MOUSE
NC score	0.081024 (rank : 387)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	141
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

BICD1_HUMAN
NC score	0.080850 (rank : 388)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	390	Target Neighborhood Hits	844	Shared Neighborhood Hits	138
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CCD11_MOUSE
NC score	0.080812 (rank : 389)	θ value	1.81305 (rank : 283)
Query Neighborhood Hits	390	Target Neighborhood Hits	498	Shared Neighborhood Hits	100
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CUTL1_MOUSE
NC score	0.080695 (rank : 390)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	390	Target Neighborhood Hits	1620	Shared Neighborhood Hits	161
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

PEPL_MOUSE
NC score	0.080542 (rank : 391)	θ value	4.03905 (rank : 329)
Query Neighborhood Hits	390	Target Neighborhood Hits	1105	Shared Neighborhood Hits	150
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

SWP70_HUMAN
NC score	0.080433 (rank : 392)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	390	Target Neighborhood Hits	973	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

NGEF_HUMAN
NC score	0.080407 (rank : 393)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	67
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BRE1A_MOUSE
NC score	0.080303 (rank : 394)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	390	Target Neighborhood Hits	1025	Shared Neighborhood Hits	146
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

SM1L2_MOUSE
NC score	0.080152 (rank : 395)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	390	Target Neighborhood Hits	918	Shared Neighborhood Hits	148
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SH21A_MOUSE
NC score	0.080151 (rank : 396)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

LETM1_HUMAN
NC score	0.080099 (rank : 397)	θ value	0.0252991 (rank : 137)
Query Neighborhood Hits	390	Target Neighborhood Hits	338	Shared Neighborhood Hits	81
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

SMC1A_MOUSE
NC score	0.080060 (rank : 398)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	390	Target Neighborhood Hits	1384	Shared Neighborhood Hits	163
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SH21A_HUMAN
NC score	0.079870 (rank : 399)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	390	Target Neighborhood Hits	89	Shared Neighborhood Hits	36
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SDCG8_MOUSE
NC score	0.079852 (rank : 400)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	390	Target Neighborhood Hits	886	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

LRC45_HUMAN
NC score	0.079811 (rank : 401)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	390	Target Neighborhood Hits	933	Shared Neighborhood Hits	133
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
NC score	0.079793 (rank : 402)	θ value	5.27518 (rank : 340)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	127
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

CK5P2_MOUSE
NC score	0.079782 (rank : 403)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	390	Target Neighborhood Hits	1151	Shared Neighborhood Hits	145
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

MYO6_MOUSE
NC score	0.079682 (rank : 404)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	390	Target Neighborhood Hits	586	Shared Neighborhood Hits	103
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

MD1L1_MOUSE
NC score	0.079608 (rank : 405)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	390	Target Neighborhood Hits	1001	Shared Neighborhood Hits	134
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

LRRF2_HUMAN
NC score	0.079578 (rank : 406)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	390	Target Neighborhood Hits	791	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

CCD11_HUMAN
NC score	0.079564 (rank : 407)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	390	Target Neighborhood Hits	822	Shared Neighborhood Hits	132
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

PCNT_MOUSE
NC score	0.079435 (rank : 408)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	390	Target Neighborhood Hits	1207	Shared Neighborhood Hits	149
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

ARHGA_HUMAN
NC score	0.079391 (rank : 409)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	390	Target Neighborhood Hits	187	Shared Neighborhood Hits	39
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

EP15_HUMAN
NC score	0.079282 (rank : 410)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	390	Target Neighborhood Hits	1021	Shared Neighborhood Hits	139
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

SMC1A_HUMAN
NC score	0.079227 (rank : 411)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	390	Target Neighborhood Hits	1346	Shared Neighborhood Hits	159
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

BICD1_MOUSE
NC score	0.078993 (rank : 412)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	390	Target Neighborhood Hits	837	Shared Neighborhood Hits	137
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

TUFT1_MOUSE
NC score	0.078909 (rank : 413)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	390	Target Neighborhood Hits	732	Shared Neighborhood Hits	135
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

TSC1_HUMAN
NC score	0.078694 (rank : 414)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	390	Target Neighborhood Hits	765	Shared Neighborhood Hits	125
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

CCHCR_MOUSE
NC score	0.078676 (rank : 415)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	390	Target Neighborhood Hits	932	Shared Neighborhood Hits	140
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

HOOK1_MOUSE
NC score	0.078632 (rank : 416)	θ value	1.38821 (rank : 270)
Query Neighborhood Hits	390	Target Neighborhood Hits	910	Shared Neighborhood Hits	138
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

CT096_HUMAN
NC score	0.078575 (rank : 417)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	390	Target Neighborhood Hits	438	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

SAS6_HUMAN
NC score	0.078520 (rank : 418)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	390	Target Neighborhood Hits	791	Shared Neighborhood Hits	126
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

UACA_HUMAN
NC score	0.078490 (rank : 419)	θ value	3.0926 (rank : 318)
Query Neighborhood Hits	390	Target Neighborhood Hits	1622	Shared Neighborhood Hits	159
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

SWP70_MOUSE
NC score	0.078453 (rank : 420)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	390	Target Neighborhood Hits	1097	Shared Neighborhood Hits	146
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SMC3_MOUSE
NC score	0.078434 (rank : 421)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	390	Target Neighborhood Hits	1187	Shared Neighborhood Hits	152
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

GRP3_HUMAN
NC score	0.078296 (rank : 422)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	390	Target Neighborhood Hits	131	Shared Neighborhood Hits	23
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

BRE1A_HUMAN
NC score	0.078285 (rank : 423)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	390	Target Neighborhood Hits	1071	Shared Neighborhood Hits	147
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

SYNE1_HUMAN
NC score	0.078228 (rank : 424)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	390	Target Neighborhood Hits	1484	Shared Neighborhood Hits	165
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SMC3_HUMAN
NC score	0.078225 (rank : 425)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	390	Target Neighborhood Hits	1186	Shared Neighborhood Hits	152
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

BPAEA_MOUSE
NC score	0.078218 (rank : 426)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	390	Target Neighborhood Hits	1480	Shared Neighborhood Hits	162
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PHLB2_MOUSE
NC score	0.078075 (rank : 427)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	140
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

LYN_HUMAN
NC score	0.078053 (rank : 428)	θ value	5.27518 (rank : 341)
Query Neighborhood Hits	390	Target Neighborhood Hits	1022	Shared Neighborhood Hits	144
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MD1L1_HUMAN
NC score	0.078051 (rank : 429)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	390	Target Neighborhood Hits	893	Shared Neighborhood Hits	121
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

SM1L2_HUMAN
NC score	0.078048 (rank : 430)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	390	Target Neighborhood Hits	1019	Shared Neighborhood Hits	148
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

RADI_HUMAN
NC score	0.078003 (rank : 431)	θ value	0.00665767 (rank : 118)
Query Neighborhood Hits	390	Target Neighborhood Hits	741	Shared Neighborhood Hits	119
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

ARHGA_MOUSE
NC score	0.077979 (rank : 432)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	390	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CJ118_HUMAN
NC score	0.077928 (rank : 433)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	390	Target Neighborhood Hits	937	Shared Neighborhood Hits	133
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

IF3A_MOUSE
NC score	0.077911 (rank : 434)	θ value	8.99809 (rank : 376)
Query Neighborhood Hits	390	Target Neighborhood Hits	871	Shared Neighborhood Hits	127
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

BLK_MOUSE
NC score	0.077906 (rank : 435)	θ value	0.0431538 (rank : 144)
Query Neighborhood Hits	390	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HIP1_HUMAN
NC score	0.077717 (rank : 436)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	142
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

RADI_MOUSE
NC score	0.077677 (rank : 437)	θ value	0.0113563 (rank : 128)
Query Neighborhood Hits	390	Target Neighborhood Hits	773	Shared Neighborhood Hits	116
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

NEMO_HUMAN
NC score	0.077646 (rank : 438)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

LYN_MOUSE
NC score	0.077603 (rank : 439)	θ value	4.03905 (rank : 327)
Query Neighborhood Hits	390	Target Neighborhood Hits	1023	Shared Neighborhood Hits	142
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

RRBP1_HUMAN
NC score	0.077570 (rank : 440)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	390	Target Neighborhood Hits	1306	Shared Neighborhood Hits	144
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RFIP4_HUMAN
NC score	0.077543 (rank : 441)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	390	Target Neighborhood Hits	785	Shared Neighborhood Hits	133
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

KMHN1_MOUSE
NC score	0.077534 (rank : 442)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	390	Target Neighborhood Hits	949	Shared Neighborhood Hits	141
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

SH21B_HUMAN
NC score	0.077343 (rank : 443)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXLNA_MOUSE
NC score	0.077342 (rank : 444)	θ value	0.47712 (rank : 232)
Query Neighborhood Hits	390	Target Neighborhood Hits	846	Shared Neighborhood Hits	126
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TMF1_HUMAN
NC score	0.077299 (rank : 445)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	390	Target Neighborhood Hits	987	Shared Neighborhood Hits	128
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

C102B_HUMAN
NC score	0.076896 (rank : 446)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	390	Target Neighborhood Hits	542	Shared Neighborhood Hits	113
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

TXLNA_HUMAN
NC score	0.076850 (rank : 447)	θ value	1.06291 (rank : 265)
Query Neighborhood Hits	390	Target Neighborhood Hits	982	Shared Neighborhood Hits	127
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

EZRI_MOUSE
NC score	0.076747 (rank : 448)	θ value	0.0193708 (rank : 134)
Query Neighborhood Hits	390	Target Neighborhood Hits	693	Shared Neighborhood Hits	112
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FYCO1_MOUSE
NC score	0.076572 (rank : 449)	θ value	1.38821 (rank : 269)
Query Neighborhood Hits	390	Target Neighborhood Hits	1059	Shared Neighborhood Hits	132
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TIAM1_HUMAN
NC score	0.076570 (rank : 450)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	390	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

RRBP1_MOUSE
NC score	0.076485 (rank : 451)	θ value	1.38821 (rank : 276)
Query Neighborhood Hits	390	Target Neighborhood Hits	1650	Shared Neighborhood Hits	154
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CCD96_MOUSE
NC score	0.076457 (rank : 452)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	390	Target Neighborhood Hits	704	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

MPP6_HUMAN
NC score	0.076398 (rank : 453)	θ value	0.279714 (rank : 214)
Query Neighborhood Hits	390	Target Neighborhood Hits	180	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

BRE1B_HUMAN
NC score	0.076305 (rank : 454)	θ value	6.88961 (rank : 355)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	127
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CCD19_HUMAN
NC score	0.076175 (rank : 455)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	390	Target Neighborhood Hits	639	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

KNTC2_HUMAN
NC score	0.076089 (rank : 456)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	390	Target Neighborhood Hits	673	Shared Neighborhood Hits	127
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

TEC_HUMAN
NC score	0.076019 (rank : 457)	θ value	0.125558 (rank : 179)
Query Neighborhood Hits	390	Target Neighborhood Hits	1006	Shared Neighborhood Hits	133
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SHAN2_MOUSE
NC score	0.075838 (rank : 458)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	390	Target Neighborhood Hits	446	Shared Neighborhood Hits	101
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TEC_MOUSE
NC score	0.075689 (rank : 459)	θ value	0.279714 (rank : 218)
Query Neighborhood Hits	390	Target Neighborhood Hits	1006	Shared Neighborhood Hits	134
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

HIP1R_MOUSE
NC score	0.075660 (rank : 460)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	136
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

TXK_HUMAN
NC score	0.075607 (rank : 461)	θ value	0.0961366 (rank : 167)
Query Neighborhood Hits	390	Target Neighborhood Hits	971	Shared Neighborhood Hits	120
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

RBCC1_HUMAN
NC score	0.075455 (rank : 462)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	390	Target Neighborhood Hits	1023	Shared Neighborhood Hits	138
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

TACC2_HUMAN
NC score	0.075453 (rank : 463)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	138
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

SHLB2_MOUSE
NC score	0.075449 (rank : 464)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	390	Target Neighborhood Hits	88	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

MPP6_MOUSE
NC score	0.075447 (rank : 465)	θ value	0.279714 (rank : 215)
Query Neighborhood Hits	390	Target Neighborhood Hits	187	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

RUFY2_HUMAN
NC score	0.075446 (rank : 466)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	390	Target Neighborhood Hits	1208	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TIAM1_MOUSE
NC score	0.075396 (rank : 467)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	390	Target Neighborhood Hits	205	Shared Neighborhood Hits	32
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SHB_MOUSE
NC score	0.075358 (rank : 468)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

HIP1R_HUMAN
NC score	0.075354 (rank : 469)	θ value	2.36792 (rank : 297)
Query Neighborhood Hits	390	Target Neighborhood Hits	809	Shared Neighborhood Hits	131
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

IF3A_HUMAN
NC score	0.075324 (rank : 470)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	390	Target Neighborhood Hits	875	Shared Neighborhood Hits	126
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

BLK_HUMAN
NC score	0.075306 (rank : 471)	θ value	1.81305 (rank : 282)
Query Neighborhood Hits	390	Target Neighborhood Hits	994	Shared Neighborhood Hits	133
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

TRAK1_HUMAN
NC score	0.075267 (rank : 472)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	390	Target Neighborhood Hits	660	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

RGNEF_MOUSE
NC score	0.075248 (rank : 473)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	390	Target Neighborhood Hits	641	Shared Neighborhood Hits	105
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CYTSA_MOUSE
NC score	0.075209 (rank : 474)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	390	Target Neighborhood Hits	1104	Shared Neighborhood Hits	147
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

HOOK1_HUMAN
NC score	0.075138 (rank : 475)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	390	Target Neighborhood Hits	942	Shared Neighborhood Hits	139
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

PKHG1_HUMAN
NC score	0.075117 (rank : 476)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

NEMO_MOUSE
NC score	0.075104 (rank : 477)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	390	Target Neighborhood Hits	658	Shared Neighborhood Hits	118
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

CNTRB_MOUSE
NC score	0.075064 (rank : 478)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	390	Target Neighborhood Hits	1029	Shared Neighborhood Hits	138
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

FYCO1_HUMAN
NC score	0.075038 (rank : 479)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	390	Target Neighborhood Hits	1149	Shared Neighborhood Hits	143
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

LIPA3_HUMAN
NC score	0.074766 (rank : 480)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	390	Target Neighborhood Hits	828	Shared Neighborhood Hits	132
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

SHLB1_MOUSE
NC score	0.074704 (rank : 481)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ARHG3_HUMAN
NC score	0.074685 (rank : 482)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	390	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

EVPL_HUMAN
NC score	0.074666 (rank : 483)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	390	Target Neighborhood Hits	895	Shared Neighborhood Hits	138
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

CCDC6_HUMAN
NC score	0.074546 (rank : 484)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	390	Target Neighborhood Hits	723	Shared Neighborhood Hits	128
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

PEPL_HUMAN
NC score	0.074536 (rank : 485)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	390	Target Neighborhood Hits	1141	Shared Neighborhood Hits	140
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

RAI14_MOUSE
NC score	0.074441 (rank : 486)	θ value	1.38821 (rank : 275)
Query Neighborhood Hits	390	Target Neighborhood Hits	1505	Shared Neighborhood Hits	158
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

GOGA2_HUMAN
NC score	0.074428 (rank : 487)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	390	Target Neighborhood Hits	856	Shared Neighborhood Hits	123
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

LRRF2_MOUSE
NC score	0.074401 (rank : 488)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	390	Target Neighborhood Hits	556	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

MYO7A_MOUSE
NC score	0.074315 (rank : 489)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	390	Target Neighborhood Hits	235	Shared Neighborhood Hits	59
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

CYTSA_HUMAN
NC score	0.074160 (rank : 490)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	390	Target Neighborhood Hits	1138	Shared Neighborhood Hits	150
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CCHCR_HUMAN
NC score	0.074152 (rank : 491)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	390	Target Neighborhood Hits	717	Shared Neighborhood Hits	120
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

SHLB2_HUMAN
NC score	0.074095 (rank : 492)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

HAPIP_HUMAN
NC score	0.074093 (rank : 493)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	390	Target Neighborhood Hits	350	Shared Neighborhood Hits	81
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

SPTB2_MOUSE
NC score	0.074005 (rank : 494)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	390	Target Neighborhood Hits	770	Shared Neighborhood Hits	126
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ITK_HUMAN
NC score	0.073876 (rank : 495)	θ value	0.125558 (rank : 170)
Query Neighborhood Hits	390	Target Neighborhood Hits	1016	Shared Neighborhood Hits	128
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

INVO_HUMAN
NC score	0.073862 (rank : 496)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	107
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

SHB_HUMAN
NC score	0.073849 (rank : 497)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	390	Target Neighborhood Hits	141	Shared Neighborhood Hits	53
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ARHG3_MOUSE
NC score	0.073734 (rank : 498)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	23
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ANR26_MOUSE
NC score	0.073678 (rank : 499)	θ value	1.38821 (rank : 267)
Query Neighborhood Hits	390	Target Neighborhood Hits	1554	Shared Neighborhood Hits	155
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

MCF2L_MOUSE
NC score	0.073673 (rank : 500)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	390	Target Neighborhood Hits	255	Shared Neighborhood Hits	72
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TRAIP_MOUSE
NC score	0.073570 (rank : 501)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	390	Target Neighborhood Hits	745	Shared Neighborhood Hits	121
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

CEP55_HUMAN
NC score	0.073567 (rank : 502)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	390	Target Neighborhood Hits	504	Shared Neighborhood Hits	105
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

CCD91_MOUSE
NC score	0.073454 (rank : 503)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	390	Target Neighborhood Hits	699	Shared Neighborhood Hits	122
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

INCE_MOUSE
NC score	0.073453 (rank : 504)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	390	Target Neighborhood Hits	903	Shared Neighborhood Hits	126
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

PHLB1_HUMAN
NC score	0.073362 (rank : 505)	θ value	3.0926 (rank : 314)
Query Neighborhood Hits	390	Target Neighborhood Hits	1038	Shared Neighborhood Hits	132
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SPAG5_HUMAN
NC score	0.073201 (rank : 506)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	120
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

TUFT1_HUMAN
NC score	0.073126 (rank : 507)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	390	Target Neighborhood Hits	686	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TXLNG_MOUSE
NC score	0.073053 (rank : 508)	θ value	3.0926 (rank : 317)
Query Neighborhood Hits	390	Target Neighborhood Hits	552	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

SHLB1_HUMAN
NC score	0.073025 (rank : 509)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	390	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

MACOI_MOUSE
NC score	0.072889 (rank : 510)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	390	Target Neighborhood Hits	620	Shared Neighborhood Hits	114
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

SHC1_MOUSE
NC score	0.072865 (rank : 511)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	390	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

INCE_HUMAN
NC score	0.072838 (rank : 512)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	390	Target Neighborhood Hits	978	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

EVPL_MOUSE
NC score	0.072793 (rank : 513)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	390	Target Neighborhood Hits	952	Shared Neighborhood Hits	138
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

CAR11_HUMAN
NC score	0.072778 (rank : 514)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	390	Target Neighborhood Hits	690	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

MYO7A_HUMAN
NC score	0.072659 (rank : 515)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	390	Target Neighborhood Hits	209	Shared Neighborhood Hits	59
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

OPTN_HUMAN
NC score	0.072534 (rank : 516)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	390	Target Neighborhood Hits	827	Shared Neighborhood Hits	123
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

ARHGG_MOUSE
NC score	0.072485 (rank : 517)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	390	Target Neighborhood Hits	152	Shared Neighborhood Hits	46
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_MOUSE
NC score	0.072289 (rank : 518)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	390	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

CT2NL_MOUSE
NC score	0.072047 (rank : 519)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	390	Target Neighborhood Hits	902	Shared Neighborhood Hits	135
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GOG8A_HUMAN
NC score	0.072039 (rank : 520)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	390	Target Neighborhood Hits	635	Shared Neighborhood Hits	114
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

CCD96_HUMAN
NC score	0.072002 (rank : 521)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	390	Target Neighborhood Hits	595	Shared Neighborhood Hits	112
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

PPIP2_MOUSE
NC score	0.071985 (rank : 522)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	390	Target Neighborhood Hits	308	Shared Neighborhood Hits	89
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

OFD1_HUMAN
NC score	0.071932 (rank : 523)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	390	Target Neighborhood Hits	753	Shared Neighborhood Hits	127
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

CTGE5_MOUSE
NC score	0.071913 (rank : 524)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	390	Target Neighborhood Hits	928	Shared Neighborhood Hits	131
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

BPAEA_HUMAN
NC score	0.071912 (rank : 525)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	390	Target Neighborhood Hits	1369	Shared Neighborhood Hits	147
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

RFIP4_MOUSE
NC score	0.071900 (rank : 526)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	390	Target Neighborhood Hits	708	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

ARHG8_HUMAN
NC score	0.071821 (rank : 527)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SNX9_HUMAN
NC score	0.071726 (rank : 528)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	390	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

CALD1_HUMAN
NC score	0.071640 (rank : 529)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	390	Target Neighborhood Hits	959	Shared Neighborhood Hits	126
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CU013_HUMAN
NC score	0.071446 (rank : 530)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	390	Target Neighborhood Hits	405	Shared Neighborhood Hits	101
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

MACOI_HUMAN
NC score	0.071385 (rank : 531)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	390	Target Neighborhood Hits	650	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

KNTC2_MOUSE
NC score	0.071364 (rank : 532)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	390	Target Neighborhood Hits	692	Shared Neighborhood Hits	119
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

CNTRB_HUMAN
NC score	0.071336 (rank : 533)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	390	Target Neighborhood Hits	690	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

SMC2_MOUSE
NC score	0.071333 (rank : 534)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	390	Target Neighborhood Hits	1131	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

MYO15_MOUSE
NC score	0.071278 (rank : 535)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	390	Target Neighborhood Hits	467	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

T3JAM_HUMAN
NC score	0.071232 (rank : 536)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	390	Target Neighborhood Hits	533	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

PPIP2_HUMAN
NC score	0.071208 (rank : 537)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	390	Target Neighborhood Hits	254	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

ANR26_HUMAN
NC score	0.071113 (rank : 538)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	390	Target Neighborhood Hits	1614	Shared Neighborhood Hits	154
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

TXLNG_HUMAN
NC score	0.071006 (rank : 539)	θ value	3.0926 (rank : 316)
Query Neighborhood Hits	390	Target Neighborhood Hits	568	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

ZN291_HUMAN
NC score	0.070938 (rank : 540)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	390	Target Neighborhood Hits	647	Shared Neighborhood Hits	109
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

CCD27_MOUSE
NC score	0.070885 (rank : 541)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	390	Target Neighborhood Hits	461	Shared Neighborhood Hits	105
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

BRE1B_MOUSE
NC score	0.070865 (rank : 542)	θ value	6.88961 (rank : 356)
Query Neighborhood Hits	390	Target Neighborhood Hits	970	Shared Neighborhood Hits	125
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

RABE2_MOUSE
NC score	0.070725 (rank : 543)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	390	Target Neighborhood Hits	598	Shared Neighborhood Hits	113
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

GCC1_HUMAN
NC score	0.070568 (rank : 544)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	390	Target Neighborhood Hits	887	Shared Neighborhood Hits	126
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

ECT2_MOUSE
NC score	0.070508 (rank : 545)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	390	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

NDE1_MOUSE
NC score	0.070438 (rank : 546)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	390	Target Neighborhood Hits	602	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

XE7_HUMAN
NC score	0.070395 (rank : 547)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	390	Target Neighborhood Hits	738	Shared Neighborhood Hits	116
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

CTGE5_HUMAN
NC score	0.070234 (rank : 548)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	390	Target Neighborhood Hits	800	Shared Neighborhood Hits	131
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

SHC1_HUMAN
NC score	0.070151 (rank : 549)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	390	Target Neighborhood Hits	170	Shared Neighborhood Hits	52
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

EP15_MOUSE
NC score	0.070051 (rank : 550)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	120
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

GCC1_MOUSE
NC score	0.070000 (rank : 551)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	390	Target Neighborhood Hits	777	Shared Neighborhood Hits	122
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

SHC2_MOUSE
NC score	0.069994 (rank : 552)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	390	Target Neighborhood Hits	144	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

TRAIP_HUMAN
NC score	0.069968 (rank : 553)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	390	Target Neighborhood Hits	780	Shared Neighborhood Hits	122
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

SHD_MOUSE
NC score	0.069924 (rank : 554)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

CCD91_HUMAN
NC score	0.069828 (rank : 555)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	390	Target Neighborhood Hits	868	Shared Neighborhood Hits	124
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

DYNA_MOUSE
NC score	0.069811 (rank : 556)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	390	Target Neighborhood Hits	1084	Shared Neighborhood Hits	141
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

ECT2_HUMAN
NC score	0.069715 (rank : 557)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	390	Target Neighborhood Hits	98	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SH24A_HUMAN
NC score	0.069604 (rank : 558)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	390	Target Neighborhood Hits	455	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

NUF2_MOUSE
NC score	0.069595 (rank : 559)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	390	Target Neighborhood Hits	585	Shared Neighborhood Hits	123
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

DMD_MOUSE
NC score	0.069586 (rank : 560)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	390	Target Neighborhood Hits	1111	Shared Neighborhood Hits	150
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

CA065_HUMAN
NC score	0.069521 (rank : 561)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	390	Target Neighborhood Hits	469	Shared Neighborhood Hits	99
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

LUZP1_HUMAN
NC score	0.069516 (rank : 562)	θ value	8.99809 (rank : 378)
Query Neighborhood Hits	390	Target Neighborhood Hits	739	Shared Neighborhood Hits	120
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

HAP1_HUMAN
NC score	0.069484 (rank : 563)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	390	Target Neighborhood Hits	606	Shared Neighborhood Hits	117
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

DYNA_HUMAN
NC score	0.069437 (rank : 564)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	390	Target Neighborhood Hits	1194	Shared Neighborhood Hits	142
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

GRB14_HUMAN
NC score	0.069429 (rank : 565)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	390	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SYNE2_HUMAN
NC score	0.069336 (rank : 566)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	390	Target Neighborhood Hits	1323	Shared Neighborhood Hits	154
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

SMC4_MOUSE
NC score	0.069321 (rank : 567)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	390	Target Neighborhood Hits	830	Shared Neighborhood Hits	130
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

MCF2_HUMAN
NC score	0.069237 (rank : 568)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	390	Target Neighborhood Hits	166	Shared Neighborhood Hits	51
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

M3K11_HUMAN
NC score	0.069176 (rank : 569)	θ value	1.81305 (rank : 287)
Query Neighborhood Hits	390	Target Neighborhood Hits	1136	Shared Neighborhood Hits	159
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MAP1A_HUMAN
NC score	0.069176 (rank : 570)	θ value	1.81305 (rank : 288)
Query Neighborhood Hits	390	Target Neighborhood Hits	1626	Shared Neighborhood Hits	154
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

LUZP1_MOUSE
NC score	0.069120 (rank : 571)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	390	Target Neighborhood Hits	940	Shared Neighborhood Hits	124
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

APS_HUMAN
NC score	0.069101 (rank : 572)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	390	Target Neighborhood Hits	162	Shared Neighborhood Hits	48
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRB14_MOUSE
NC score	0.068942 (rank : 573)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	390	Target Neighborhood Hits	149	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MYO15_HUMAN
NC score	0.068936 (rank : 574)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	390	Target Neighborhood Hits	671	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

CSK_HUMAN
NC score	0.068861 (rank : 575)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	390	Target Neighborhood Hits	1009	Shared Neighborhood Hits	125
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CRCM_HUMAN
NC score	0.068829 (rank : 576)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	390	Target Neighborhood Hits	520	Shared Neighborhood Hits	105
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

CCD45_HUMAN
NC score	0.068809 (rank : 577)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	390	Target Neighborhood Hits	525	Shared Neighborhood Hits	114
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

SPTB2_HUMAN
NC score	0.068806 (rank : 578)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	390	Target Neighborhood Hits	748	Shared Neighborhood Hits	124
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CSK_MOUSE
NC score	0.068762 (rank : 579)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	390	Target Neighborhood Hits	1009	Shared Neighborhood Hits	125
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CCD27_HUMAN
NC score	0.068741 (rank : 580)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	108
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

SHC2_HUMAN
NC score	0.068715 (rank : 581)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	390	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHE_MOUSE
NC score	0.068672 (rank : 582)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	390	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PTK6_MOUSE
NC score	0.068656 (rank : 583)	θ value	5.27518 (rank : 347)
Query Neighborhood Hits	390	Target Neighborhood Hits	1026	Shared Neighborhood Hits	145
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

CUTL1_HUMAN
NC score	0.068650 (rank : 584)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	390	Target Neighborhood Hits	1574	Shared Neighborhood Hits	151
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

PTK6_HUMAN
NC score	0.068449 (rank : 585)	θ value	8.99809 (rank : 384)
Query Neighborhood Hits	390	Target Neighborhood Hits	1020	Shared Neighborhood Hits	151
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

UTRO_HUMAN
NC score	0.068091 (rank : 586)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	390	Target Neighborhood Hits	960	Shared Neighborhood Hits	133
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

CKAP4_HUMAN
NC score	0.067874 (rank : 587)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	390	Target Neighborhood Hits	592	Shared Neighborhood Hits	106
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

MPP9_HUMAN
NC score	0.067849 (rank : 588)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	390	Target Neighborhood Hits	529	Shared Neighborhood Hits	110
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

RUFY2_MOUSE
NC score	0.067845 (rank : 589)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	390	Target Neighborhood Hits	820	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

NUF2_HUMAN
NC score	0.067802 (rank : 590)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	390	Target Neighborhood Hits	661	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

TXLNB_HUMAN
NC score	0.067788 (rank : 591)	θ value	6.88961 (rank : 366)
Query Neighborhood Hits	390	Target Neighborhood Hits	912	Shared Neighborhood Hits	118
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

BPA1_MOUSE
NC score	0.067679 (rank : 592)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	390	Target Neighborhood Hits	1477	Shared Neighborhood Hits	152
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

M3KL4_HUMAN
NC score	0.067471 (rank : 593)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	390	Target Neighborhood Hits	1087	Shared Neighborhood Hits	182
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

ZWINT_MOUSE
NC score	0.067451 (rank : 594)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	390	Target Neighborhood Hits	497	Shared Neighborhood Hits	106
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

MACF4_HUMAN
NC score	0.067445 (rank : 595)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	390	Target Neighborhood Hits	1321	Shared Neighborhood Hits	151
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

PLEC1_HUMAN
NC score	0.067383 (rank : 596)	θ value	0.813845 (rank : 250)
Query Neighborhood Hits	390	Target Neighborhood Hits	1326	Shared Neighborhood Hits	149
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SHC3_MOUSE
NC score	0.067213 (rank : 597)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

RUFY3_HUMAN
NC score	0.067183 (rank : 598)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	125
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SHE_HUMAN
NC score	0.067159 (rank : 599)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	390	Target Neighborhood Hits	164	Shared Neighborhood Hits	51
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

HOME2_MOUSE
NC score	0.067118 (rank : 600)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	390	Target Neighborhood Hits	882	Shared Neighborhood Hits	139
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

CCD93_HUMAN
NC score	0.067080 (rank : 601)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	390	Target Neighborhood Hits	600	Shared Neighborhood Hits	113
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

GNRP_MOUSE
NC score	0.067006 (rank : 602)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	33
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

MIPO1_HUMAN
NC score	0.066949 (rank : 603)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	390	Target Neighborhood Hits	486	Shared Neighborhood Hits	109
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

DMD_HUMAN
NC score	0.066925 (rank : 604)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	390	Target Neighborhood Hits	1135	Shared Neighborhood Hits	146
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

TEX9_MOUSE
NC score	0.066801 (rank : 605)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	390	Target Neighborhood Hits	581	Shared Neighborhood Hits	115
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

CENB2_HUMAN
NC score	0.066705 (rank : 606)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	390	Target Neighborhood Hits	425	Shared Neighborhood Hits	47
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

RUSC2_MOUSE
NC score	0.066658 (rank : 607)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	390	Target Neighborhood Hits	305	Shared Neighborhood Hits	61
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

HSH2D_HUMAN
NC score	0.066649 (rank : 608)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	390	Target Neighborhood Hits	159	Shared Neighborhood Hits	44
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

TPM1_HUMAN
NC score	0.066571 (rank : 609)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	390	Target Neighborhood Hits	716	Shared Neighborhood Hits	124
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

CF152_MOUSE
NC score	0.066493 (rank : 610)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	390	Target Neighborhood Hits	597	Shared Neighborhood Hits	116
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CKAP4_MOUSE
NC score	0.066461 (rank : 611)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	390	Target Neighborhood Hits	596	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

TPM1_MOUSE
NC score	0.066403 (rank : 612)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	390	Target Neighborhood Hits	729	Shared Neighborhood Hits	125
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

MRCKB_MOUSE
NC score	0.066331 (rank : 613)	θ value	1.81305 (rank : 289)
Query Neighborhood Hits	390	Target Neighborhood Hits	2180	Shared Neighborhood Hits	217
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

LIPB1_MOUSE
NC score	0.066299 (rank : 614)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	390	Target Neighborhood Hits	727	Shared Neighborhood Hits	117
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

GNRP_HUMAN
NC score	0.066252 (rank : 615)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	390	Target Neighborhood Hits	239	Shared Neighborhood Hits	46
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

POF1B_MOUSE
NC score	0.066240 (rank : 616)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	390	Target Neighborhood Hits	530	Shared Neighborhood Hits	107
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

POF1B_HUMAN
NC score	0.066180 (rank : 617)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	390	Target Neighborhood Hits	494	Shared Neighborhood Hits	106
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

RPGR1_HUMAN
NC score	0.066123 (rank : 618)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	390	Target Neighborhood Hits	578	Shared Neighborhood Hits	102
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CDR2_MOUSE
NC score	0.066067 (rank : 619)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	390	Target Neighborhood Hits	482	Shared Neighborhood Hits	100
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

TPM4_MOUSE
NC score	0.065865 (rank : 620)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	390	Target Neighborhood Hits	703	Shared Neighborhood Hits	121
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

LIPA3_MOUSE
NC score	0.065790 (rank : 621)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	117
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

TPM3_HUMAN
NC score	0.065666 (rank : 622)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	390	Target Neighborhood Hits	689	Shared Neighborhood Hits	118
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
NC score	0.065662 (rank : 623)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	390	Target Neighborhood Hits	676	Shared Neighborhood Hits	118
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

RAI14_HUMAN
NC score	0.065598 (rank : 624)	θ value	0.00869519 (rank : 122)
Query Neighborhood Hits	390	Target Neighborhood Hits	1367	Shared Neighborhood Hits	149
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ARHGG_HUMAN
NC score	0.065552 (rank : 625)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	390	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CAR14_HUMAN
NC score	0.065396 (rank : 626)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	390	Target Neighborhood Hits	449	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

EZRI_HUMAN
NC score	0.065213 (rank : 627)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	390	Target Neighborhood Hits	663	Shared Neighborhood Hits	108
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MRCKB_HUMAN
NC score	0.065208 (rank : 628)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	390	Target Neighborhood Hits	2239	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

LETM1_MOUSE
NC score	0.065179 (rank : 629)	θ value	0.21417 (rank : 197)
Query Neighborhood Hits	390	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

SPC24_HUMAN
NC score	0.065172 (rank : 630)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	390	Target Neighborhood Hits	324	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

VDP_HUMAN
NC score	0.065034 (rank : 631)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	390	Target Neighborhood Hits	645	Shared Neighborhood Hits	116
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

M3K9_HUMAN
NC score	0.065032 (rank : 632)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	390	Target Neighborhood Hits	1123	Shared Neighborhood Hits	173
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CENPJ_HUMAN
NC score	0.065001 (rank : 633)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	390	Target Neighborhood Hits	721	Shared Neighborhood Hits	122
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

MACF1_MOUSE
NC score	0.064919 (rank : 634)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	390	Target Neighborhood Hits	1313	Shared Neighborhood Hits	152
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

ABL1_HUMAN
NC score	0.064902 (rank : 635)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	390	Target Neighborhood Hits	1220	Shared Neighborhood Hits	134
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ITK_MOUSE
NC score	0.064794 (rank : 636)	θ value	4.03905 (rank : 325)
Query Neighborhood Hits	390	Target Neighborhood Hits	985	Shared Neighborhood Hits	115
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TEX9_HUMAN
NC score	0.064652 (rank : 637)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	390	Target Neighborhood Hits	541	Shared Neighborhood Hits	105
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

ABL1_MOUSE
NC score	0.064512 (rank : 638)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	390	Target Neighborhood Hits	1178	Shared Neighborhood Hits	130
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TPM2_HUMAN
NC score	0.064459 (rank : 639)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	390	Target Neighborhood Hits	677	Shared Neighborhood Hits	114
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

RUFY3_MOUSE
NC score	0.064391 (rank : 640)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	390	Target Neighborhood Hits	579	Shared Neighborhood Hits	121
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

CCD42_HUMAN
NC score	0.064079 (rank : 641)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	390	Target Neighborhood Hits	406	Shared Neighborhood Hits	90
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CF182_MOUSE
NC score	0.064037 (rank : 642)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	390	Target Neighborhood Hits	551	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

HOOK2_HUMAN
NC score	0.063988 (rank : 643)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	390	Target Neighborhood Hits	714	Shared Neighborhood Hits	119
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

SPAG5_MOUSE
NC score	0.063974 (rank : 644)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	390	Target Neighborhood Hits	612	Shared Neighborhood Hits	106
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SHC3_HUMAN
NC score	0.063971 (rank : 645)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	390	Target Neighborhood Hits	155	Shared Neighborhood Hits	46
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

WDR67_HUMAN
NC score	0.063851 (rank : 646)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	390	Target Neighborhood Hits	782	Shared Neighborhood Hits	114
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

ABL2_HUMAN
NC score	0.063606 (rank : 647)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	390	Target Neighborhood Hits	1045	Shared Neighborhood Hits	118
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

TPM2_MOUSE
NC score	0.063586 (rank : 648)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	390	Target Neighborhood Hits	676	Shared Neighborhood Hits	116
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

CEP57_MOUSE
NC score	0.063575 (rank : 649)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	390	Target Neighborhood Hits	580	Shared Neighborhood Hits	116
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

MRCKA_HUMAN
NC score	0.063524 (rank : 650)	θ value	0.365318 (rank : 223)
Query Neighborhood Hits	390	Target Neighborhood Hits	1999	Shared Neighborhood Hits	199
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CEP57_HUMAN
NC score	0.063515 (rank : 651)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	390	Target Neighborhood Hits	576	Shared Neighborhood Hits	113
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

HOOK2_MOUSE
NC score	0.063464 (rank : 652)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	390	Target Neighborhood Hits	736	Shared Neighborhood Hits	118
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

LCK_HUMAN
NC score	0.063444 (rank : 653)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	390	Target Neighborhood Hits	987	Shared Neighborhood Hits	112
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BAIP2_MOUSE
NC score	0.063417 (rank : 654)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

LIPB1_HUMAN
NC score	0.063404 (rank : 655)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	390	Target Neighborhood Hits	640	Shared Neighborhood Hits	108
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

SHD_HUMAN
NC score	0.063272 (rank : 656)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	390	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

NEST_HUMAN
NC score	0.063226 (rank : 657)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	390	Target Neighborhood Hits	1305	Shared Neighborhood Hits	144
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

IF2P_HUMAN
NC score	0.063125 (rank : 658)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	390	Target Neighborhood Hits	889	Shared Neighborhood Hits	117
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

LCK_MOUSE
NC score	0.063080 (rank : 659)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	390	Target Neighborhood Hits	981	Shared Neighborhood Hits	112
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MYO1A_HUMAN
NC score	0.062911 (rank : 660)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	390	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

CEP70_HUMAN
NC score	0.062824 (rank : 661)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	390	Target Neighborhood Hits	432	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

KINH_HUMAN
NC score	0.062820 (rank : 662)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	390	Target Neighborhood Hits	1231	Shared Neighborhood Hits	156
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

TACC3_MOUSE
NC score	0.062787 (rank : 663)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	390	Target Neighborhood Hits	607	Shared Neighborhood Hits	119
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

MYO1C_MOUSE
NC score	0.062756 (rank : 664)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	390	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

RUFY1_HUMAN
NC score	0.062716 (rank : 665)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	390	Target Neighborhood Hits	848	Shared Neighborhood Hits	127
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

MYO1C_HUMAN
NC score	0.062632 (rank : 666)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

TPM4_HUMAN
NC score	0.062534 (rank : 667)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	390	Target Neighborhood Hits	525	Shared Neighborhood Hits	107
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

MYO1B_MOUSE
NC score	0.062528 (rank : 668)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	390	Target Neighborhood Hits	71	Shared Neighborhood Hits	23
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

MYO1B_HUMAN
NC score	0.062528 (rank : 669)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	390	Target Neighborhood Hits	70	Shared Neighborhood Hits	23
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

MYO1D_HUMAN
NC score	0.062501 (rank : 670)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	390	Target Neighborhood Hits	56	Shared Neighborhood Hits	22
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

MYO1D_MOUSE
NC score	0.062378 (rank : 671)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	390	Target Neighborhood Hits	57	Shared Neighborhood Hits	22
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

SNX9_MOUSE
NC score	0.062248 (rank : 672)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	390	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

TACC3_HUMAN
NC score	0.062211 (rank : 673)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	390	Target Neighborhood Hits	779	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

MMRN1_HUMAN
NC score	0.062082 (rank : 674)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	390	Target Neighborhood Hits	636	Shared Neighborhood Hits	107
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

CAR14_MOUSE
NC score	0.062034 (rank : 675)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	390	Target Neighborhood Hits	526	Shared Neighborhood Hits	109
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

TXLNB_MOUSE
NC score	0.062033 (rank : 676)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	390	Target Neighborhood Hits	640	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

ADIP_HUMAN
NC score	0.061988 (rank : 677)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	390	Target Neighborhood Hits	470	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

KIF4A_HUMAN
NC score	0.061961 (rank : 678)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	390	Target Neighborhood Hits	1159	Shared Neighborhood Hits	146
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CTGE6_HUMAN
NC score	0.061654 (rank : 679)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	390	Target Neighborhood Hits	650	Shared Neighborhood Hits	113
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

CENB5_HUMAN
NC score	0.061436 (rank : 680)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	390	Target Neighborhood Hits	395	Shared Neighborhood Hits	34
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

RLP24_MOUSE
NC score	0.061353 (rank : 681)	θ value	1.81305 (rank : 291)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q99L28	Gene names
Domain Architecture	No domain graphic available
Description	Probable ribosome biogenesis protein RLP24.

MACF1_HUMAN
NC score	0.061204 (rank : 682)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	390	Target Neighborhood Hits	1341	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

RPGR1_MOUSE
NC score	0.061103 (rank : 683)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	390	Target Neighborhood Hits	713	Shared Neighborhood Hits	92
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

STS2_HUMAN
NC score	0.060972 (rank : 684)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

LZTS1_HUMAN
NC score	0.060893 (rank : 685)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

SHAN1_HUMAN
NC score	0.060886 (rank : 686)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	390	Target Neighborhood Hits	1041	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

APOA4_MOUSE
NC score	0.060857 (rank : 687)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	390	Target Neighborhood Hits	435	Shared Neighborhood Hits	91
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

CF182_HUMAN
NC score	0.060621 (rank : 688)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	390	Target Neighborhood Hits	474	Shared Neighborhood Hits	104
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

MERL_MOUSE
NC score	0.060562 (rank : 689)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	390	Target Neighborhood Hits	524	Shared Neighborhood Hits	99
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

TACC2_MOUSE
NC score	0.060494 (rank : 690)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	390	Target Neighborhood Hits	774	Shared Neighborhood Hits	129
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

NDEL1_HUMAN
NC score	0.060437 (rank : 691)	θ value	5.27518 (rank : 343)
Query Neighborhood Hits	390	Target Neighborhood Hits	415	Shared Neighborhood Hits	90
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

AL2SB_HUMAN
NC score	0.060220 (rank : 692)	θ value	5.27518 (rank : 336)
Query Neighborhood Hits	390	Target Neighborhood Hits	294	Shared Neighborhood Hits	79
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

NDEL1_MOUSE
NC score	0.060149 (rank : 693)	θ value	5.27518 (rank : 344)
Query Neighborhood Hits	390	Target Neighborhood Hits	420	Shared Neighborhood Hits	90
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

MERL_HUMAN
NC score	0.060117 (rank : 694)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	104
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

CTRO_MOUSE
NC score	0.059943 (rank : 695)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	390	Target Neighborhood Hits	2344	Shared Neighborhood Hits	208
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

AN30A_HUMAN
NC score	0.059806 (rank : 696)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	390	Target Neighborhood Hits	1119	Shared Neighborhood Hits	133
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANR18_HUMAN
NC score	0.059719 (rank : 697)	θ value	8.99809 (rank : 368)
Query Neighborhood Hits	390	Target Neighborhood Hits	1106	Shared Neighborhood Hits	144
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

GRB7_MOUSE
NC score	0.059689 (rank : 698)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	390	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CCD45_MOUSE
NC score	0.059403 (rank : 699)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	390	Target Neighborhood Hits	663	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

BAIP2_HUMAN
NC score	0.059284 (rank : 700)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	390	Target Neighborhood Hits	192	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

KINH_MOUSE
NC score	0.059110 (rank : 701)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	390	Target Neighborhood Hits	1082	Shared Neighborhood Hits	147
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

LZTS1_MOUSE
NC score	0.059106 (rank : 702)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	390	Target Neighborhood Hits	540	Shared Neighborhood Hits	102
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

RBM25_HUMAN
NC score	0.058920 (rank : 703)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	390	Target Neighborhood Hits	682	Shared Neighborhood Hits	104
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

TRAK2_HUMAN
NC score	0.058885 (rank : 704)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	390	Target Neighborhood Hits	476	Shared Neighborhood Hits	98
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

CENPH_HUMAN
NC score	0.058856 (rank : 705)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	390	Target Neighborhood Hits	335	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

GLE1_MOUSE
NC score	0.058848 (rank : 706)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	390	Target Neighborhood Hits	504	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

TEKT1_MOUSE
NC score	0.058785 (rank : 707)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	390	Target Neighborhood Hits	399	Shared Neighborhood Hits	102
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

CENB1_HUMAN
NC score	0.058704 (rank : 708)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	390	Target Neighborhood Hits	383	Shared Neighborhood Hits	25
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

LIPB2_HUMAN
NC score	0.058292 (rank : 709)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	390	Target Neighborhood Hits	599	Shared Neighborhood Hits	107
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

CAF1A_MOUSE
NC score	0.058266 (rank : 710)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	390	Target Neighborhood Hits	736	Shared Neighborhood Hits	110
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

PHLB1_MOUSE
NC score	0.058209 (rank : 711)	θ value	1.38821 (rank : 273)
Query Neighborhood Hits	390	Target Neighborhood Hits	678	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

FGD4_MOUSE
NC score	0.058164 (rank : 712)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

RLP24_HUMAN
NC score	0.058101 (rank : 713)	θ value	2.36792 (rank : 300)
Query Neighborhood Hits	390	Target Neighborhood Hits	63	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHA3, Q561V8, Q8N6S8, Q96B04, Q96C76, Q96HJ1	Gene names	C15orf15, RPL24L
Domain Architecture	No domain graphic available
Description	Probable ribosome biogenesis protein RLP24 (Ribosomal protein L24- like).

RABE2_HUMAN
NC score	0.057851 (rank : 714)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	390	Target Neighborhood Hits	545	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RUFY1_MOUSE
NC score	0.057598 (rank : 715)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	390	Target Neighborhood Hits	765	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

DOCK1_HUMAN
NC score	0.057592 (rank : 716)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	92
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ROCK2_MOUSE
NC score	0.057374 (rank : 717)	θ value	0.0961366 (rank : 163)
Query Neighborhood Hits	390	Target Neighborhood Hits	2072	Shared Neighborhood Hits	192
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SEC20_MOUSE
NC score	0.057350 (rank : 718)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	390	Target Neighborhood Hits	323	Shared Neighborhood Hits	90
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

CAR10_HUMAN
NC score	0.057348 (rank : 719)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	390	Target Neighborhood Hits	569	Shared Neighborhood Hits	115
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

STIM1_HUMAN
NC score	0.057319 (rank : 720)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	390	Target Neighborhood Hits	665	Shared Neighborhood Hits	117
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

PLVAP_HUMAN
NC score	0.057318 (rank : 721)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	390	Target Neighborhood Hits	397	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

FARP2_MOUSE
NC score	0.057121 (rank : 722)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	390	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

LNK_HUMAN
NC score	0.056962 (rank : 723)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FGD4_HUMAN
NC score	0.056836 (rank : 724)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	390	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

T3JAM_MOUSE
NC score	0.056822 (rank : 725)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	390	Target Neighborhood Hits	535	Shared Neighborhood Hits	99
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

3BP5_HUMAN
NC score	0.056774 (rank : 726)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	390	Target Neighborhood Hits	375	Shared Neighborhood Hits	90
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

KIF5C_MOUSE
NC score	0.056423 (rank : 727)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	152
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

CEP70_MOUSE
NC score	0.056373 (rank : 728)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	390	Target Neighborhood Hits	532	Shared Neighborhood Hits	102
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

NTBP1_MOUSE
NC score	0.056237 (rank : 729)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	390	Target Neighborhood Hits	528	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

LIPB2_MOUSE
NC score	0.056199 (rank : 730)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	390	Target Neighborhood Hits	570	Shared Neighborhood Hits	99
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

PININ_HUMAN
NC score	0.056159 (rank : 731)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	390	Target Neighborhood Hits	753	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

GRB7_HUMAN
NC score	0.056141 (rank : 732)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

LNK_MOUSE
NC score	0.055872 (rank : 733)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	390	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SKIL_MOUSE
NC score	0.055852 (rank : 734)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	390	Target Neighborhood Hits	719	Shared Neighborhood Hits	124
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

BI2L1_HUMAN
NC score	0.055814 (rank : 735)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SPC25_HUMAN
NC score	0.055789 (rank : 736)	θ value	8.99809 (rank : 388)
Query Neighborhood Hits	390	Target Neighborhood Hits	273	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

LZTS2_HUMAN
NC score	0.055766 (rank : 737)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	390	Target Neighborhood Hits	427	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

GRB10_MOUSE
NC score	0.055693 (rank : 738)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	390	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

UN13A_HUMAN
NC score	0.055663 (rank : 739)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	390	Target Neighborhood Hits	285	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

TACC1_MOUSE
NC score	0.055625 (rank : 740)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	390	Target Neighborhood Hits	667	Shared Neighborhood Hits	111
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

STIM1_MOUSE
NC score	0.055613 (rank : 741)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	390	Target Neighborhood Hits	660	Shared Neighborhood Hits	114
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

M3K10_HUMAN
NC score	0.055428 (rank : 742)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	390	Target Neighborhood Hits	1071	Shared Neighborhood Hits	164
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

RASF8_HUMAN
NC score	0.055317 (rank : 743)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	390	Target Neighborhood Hits	469	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

ROCK1_MOUSE
NC score	0.055242 (rank : 744)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	390	Target Neighborhood Hits	2126	Shared Neighborhood Hits	190
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

3BP5_MOUSE
NC score	0.055237 (rank : 745)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	390	Target Neighborhood Hits	346	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

CCD22_MOUSE
NC score	0.055106 (rank : 746)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	390	Target Neighborhood Hits	268	Shared Neighborhood Hits	74
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

ADIP_MOUSE
NC score	0.055043 (rank : 747)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	390	Target Neighborhood Hits	415	Shared Neighborhood Hits	101
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

STS1_MOUSE
NC score	0.054973 (rank : 748)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	390	Target Neighborhood Hits	104	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

CEP35_HUMAN
NC score	0.054817 (rank : 749)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	390	Target Neighborhood Hits	811	Shared Neighborhood Hits	112
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

FGD3_MOUSE
NC score	0.054756 (rank : 750)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	390	Target Neighborhood Hits	257	Shared Neighborhood Hits	28
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

CDC37_HUMAN
NC score	0.054590 (rank : 751)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	390	Target Neighborhood Hits	506	Shared Neighborhood Hits	92
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

FYV1_MOUSE
NC score	0.054574 (rank : 752)	θ value	0.0563607 (rank : 151)
Query Neighborhood Hits	390	Target Neighborhood Hits	191	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

STS1_HUMAN
NC score	0.054552 (rank : 753)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	390	Target Neighborhood Hits	106	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SLY_MOUSE
NC score	0.054324 (rank : 754)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	390	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

IMMT_HUMAN
NC score	0.054287 (rank : 755)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	390	Target Neighborhood Hits	494	Shared Neighborhood Hits	91
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

RBBP8_HUMAN
NC score	0.054154 (rank : 756)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	390	Target Neighborhood Hits	476	Shared Neighborhood Hits	89
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

K0552_HUMAN
NC score	0.054113 (rank : 757)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	390	Target Neighborhood Hits	442	Shared Neighborhood Hits	91
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

CTGE2_HUMAN
NC score	0.054077 (rank : 758)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	390	Target Neighborhood Hits	594	Shared Neighborhood Hits	111
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

ROCK2_HUMAN
NC score	0.054037 (rank : 759)	θ value	1.81305 (rank : 292)
Query Neighborhood Hits	390	Target Neighborhood Hits	2073	Shared Neighborhood Hits	189
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SH2D3_MOUSE
NC score	0.054020 (rank : 760)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	390	Target Neighborhood Hits	174	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

AMOL2_HUMAN
NC score	0.053866 (rank : 761)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	390	Target Neighborhood Hits	603	Shared Neighborhood Hits	110
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

FARP2_HUMAN
NC score	0.053677 (rank : 762)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	390	Target Neighborhood Hits	240	Shared Neighborhood Hits	38
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PININ_MOUSE
NC score	0.053470 (rank : 763)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	390	Target Neighborhood Hits	777	Shared Neighborhood Hits	101
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

CUTL2_HUMAN
NC score	0.053292 (rank : 764)	θ value	0.62314 (rank : 234)
Query Neighborhood Hits	390	Target Neighborhood Hits	906	Shared Neighborhood Hits	110
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

LBN_MOUSE
NC score	0.053285 (rank : 765)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	390	Target Neighborhood Hits	310	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

MORC3_HUMAN
NC score	0.053252 (rank : 766)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	390	Target Neighborhood Hits	489	Shared Neighborhood Hits	100
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

UN13B_HUMAN
NC score	0.053110 (rank : 767)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	30
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

LRRF1_HUMAN
NC score	0.053090 (rank : 768)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	390	Target Neighborhood Hits	625	Shared Neighborhood Hits	107
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

SPTN5_HUMAN
NC score	0.053023 (rank : 769)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	390	Target Neighborhood Hits	674	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

GRB10_HUMAN
NC score	0.052994 (rank : 770)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	390	Target Neighborhood Hits	147	Shared Neighborhood Hits	47
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

KIF4A_MOUSE
NC score	0.052961 (rank : 771)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	390	Target Neighborhood Hits	1033	Shared Neighborhood Hits	138
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

LMNB1_HUMAN
NC score	0.052795 (rank : 772)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	390	Target Neighborhood Hits	714	Shared Neighborhood Hits	131
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

INVO_MOUSE
NC score	0.052791 (rank : 773)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	390	Target Neighborhood Hits	474	Shared Neighborhood Hits	79
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

KIF5C_HUMAN
NC score	0.052653 (rank : 774)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	390	Target Neighborhood Hits	974	Shared Neighborhood Hits	142
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

SRMS_MOUSE
NC score	0.052531 (rank : 775)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	390	Target Neighborhood Hits	964	Shared Neighborhood Hits	99
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

HOME1_MOUSE
NC score	0.052157 (rank : 776)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	390	Target Neighborhood Hits	630	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

NEB2_MOUSE
NC score	0.052106 (rank : 777)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	390	Target Neighborhood Hits	889	Shared Neighborhood Hits	126
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

MATK_MOUSE
NC score	0.052099 (rank : 778)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	390	Target Neighborhood Hits	952	Shared Neighborhood Hits	88
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

TARA_MOUSE
NC score	0.052062 (rank : 779)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	390	Target Neighborhood Hits	1133	Shared Neighborhood Hits	125
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TACC1_HUMAN
NC score	0.052006 (rank : 780)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	390	Target Neighborhood Hits	597	Shared Neighborhood Hits	107
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TEKT1_HUMAN
NC score	0.051995 (rank : 781)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	390	Target Neighborhood Hits	289	Shared Neighborhood Hits	89
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

BCN1_HUMAN
NC score	0.051949 (rank : 782)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	390	Target Neighborhood Hits	395	Shared Neighborhood Hits	92
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

SH24A_MOUSE
NC score	0.051909 (rank : 783)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	390	Target Neighborhood Hits	326	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

PTN11_MOUSE
NC score	0.051857 (rank : 784)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.051849 (rank : 785)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	390	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

AMOL2_MOUSE
NC score	0.051805 (rank : 786)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	390	Target Neighborhood Hits	591	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

ROCK1_HUMAN
NC score	0.051804 (rank : 787)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	390	Target Neighborhood Hits	2000	Shared Neighborhood Hits	184
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

FGD6_MOUSE
NC score	0.051795 (rank : 788)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	390	Target Neighborhood Hits	282	Shared Neighborhood Hits	39
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZWINT_HUMAN
NC score	0.051785 (rank : 789)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	390	Target Neighborhood Hits	333	Shared Neighborhood Hits	82
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

MRIP_HUMAN
NC score	0.051729 (rank : 790)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	390	Target Neighborhood Hits	578	Shared Neighborhood Hits	95
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

CCD93_MOUSE
NC score	0.051683 (rank : 791)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	390	Target Neighborhood Hits	362	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD22_HUMAN
NC score	0.051604 (rank : 792)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	390	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

APS_MOUSE
NC score	0.051539 (rank : 793)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	390	Target Neighborhood Hits	134	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

CTRO_HUMAN
NC score	0.051530 (rank : 794)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	390	Target Neighborhood Hits	2092	Shared Neighborhood Hits	188
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MATK_HUMAN
NC score	0.051417 (rank : 795)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	390	Target Neighborhood Hits	954	Shared Neighborhood Hits	84
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

RASF8_MOUSE
NC score	0.051410 (rank : 796)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	390	Target Neighborhood Hits	391	Shared Neighborhood Hits	89
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

FGD2_HUMAN
NC score	0.051368 (rank : 797)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	390	Target Neighborhood Hits	151	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

PCTL_MOUSE
NC score	0.051331 (rank : 798)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	390	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

LMNB1_MOUSE
NC score	0.051324 (rank : 799)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	390	Target Neighborhood Hits	719	Shared Neighborhood Hits	127
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

FGD3_HUMAN
NC score	0.051322 (rank : 800)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	390	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

PLCB4_HUMAN
NC score	0.051296 (rank : 801)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	390	Target Neighborhood Hits	658	Shared Neighborhood Hits	111
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

LRSM1_HUMAN
NC score	0.051294 (rank : 802)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	390	Target Neighborhood Hits	1078	Shared Neighborhood Hits	124
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

SH2D3_HUMAN
NC score	0.051232 (rank : 803)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	390	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

AMPH_HUMAN
NC score	0.051195 (rank : 804)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	390	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ARHG1_HUMAN
NC score	0.051131 (rank : 805)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	390	Target Neighborhood Hits	176	Shared Neighborhood Hits	23
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SNX23_HUMAN
NC score	0.051074 (rank : 806)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	390	Target Neighborhood Hits	944	Shared Neighborhood Hits	131
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

FYV1_HUMAN
NC score	0.051043 (rank : 807)	θ value	0.0431538 (rank : 146)
Query Neighborhood Hits	390	Target Neighborhood Hits	217	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

PDZD8_HUMAN
NC score	0.051040 (rank : 808)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	390	Target Neighborhood Hits	185	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SRMS_HUMAN
NC score	0.051033 (rank : 809)	θ value	4.03905 (rank : 333)
Query Neighborhood Hits	390	Target Neighborhood Hits	946	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

NEB2_HUMAN
NC score	0.051018 (rank : 810)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	390	Target Neighborhood Hits	883	Shared Neighborhood Hits	124
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

HC127_HUMAN
NC score	0.050995 (rank : 811)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
NC score	0.050995 (rank : 812)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	390	Target Neighborhood Hits	292	Shared Neighborhood Hits	70
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

MRIP_MOUSE
NC score	0.050971 (rank : 813)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	390	Target Neighborhood Hits	569	Shared Neighborhood Hits	97
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

CDR2_HUMAN
NC score	0.050950 (rank : 814)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	390	Target Neighborhood Hits	404	Shared Neighborhood Hits	89
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

GP73_MOUSE
NC score	0.050896 (rank : 815)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	390	Target Neighborhood Hits	506	Shared Neighborhood Hits	92
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

PCTL_HUMAN
NC score	0.050727 (rank : 816)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	390	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

ENAH_HUMAN
NC score	0.050593 (rank : 817)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	390	Target Neighborhood Hits	784	Shared Neighborhood Hits	112
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

FARP1_HUMAN
NC score	0.050557 (rank : 818)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	390	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

LZTS2_MOUSE
NC score	0.050553 (rank : 819)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	390	Target Neighborhood Hits	423	Shared Neighborhood Hits	86
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

BIN1_MOUSE
NC score	0.050502 (rank : 820)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	390	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

DP13A_HUMAN
NC score	0.050420 (rank : 821)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	390	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

AMOT_HUMAN
NC score	0.050262 (rank : 822)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	390	Target Neighborhood Hits	712	Shared Neighborhood Hits	105
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

STXB4_HUMAN
NC score	0.050202 (rank : 823)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	390	Target Neighborhood Hits	616	Shared Neighborhood Hits	103
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

BI2L1_MOUSE
NC score	0.050157 (rank : 824)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	390	Target Neighborhood Hits	197	Shared Neighborhood Hits	65
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ARHGB_HUMAN
NC score	0.050100 (rank : 825)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	390	Target Neighborhood Hits	375	Shared Neighborhood Hits	45
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

SPTB1_MOUSE
NC score	0.050071 (rank : 826)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	390	Target Neighborhood Hits	543	Shared Neighborhood Hits	103
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

FGD6_HUMAN
NC score	0.050003 (rank : 827)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	390	Target Neighborhood Hits	237	Shared Neighborhood Hits	31
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

LMNB2_HUMAN
NC score	0.049815 (rank : 828)	θ value	1.81305 (rank : 286)
Query Neighborhood Hits	390	Target Neighborhood Hits	723	Shared Neighborhood Hits	116
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

DYDC1_HUMAN
NC score	0.049354 (rank : 829)	θ value	0.21417 (rank : 196)
Query Neighborhood Hits	390	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q8WWB3, Q5QP03, Q5QP04, Q6WNP4, Q6ZU87	Gene names	DYDC1, DPY30D1
Domain Architecture	No domain graphic available
Description	DPY30 domain-containing protein 1 (RSD-9).

GFAP_MOUSE
NC score	0.047732 (rank : 830)	θ value	0.0736092 (rank : 155)
Query Neighborhood Hits	390	Target Neighborhood Hits	725	Shared Neighborhood Hits	132
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

LMNB2_MOUSE
NC score	0.047213 (rank : 831)	θ value	6.88961 (rank : 361)
Query Neighborhood Hits	390	Target Neighborhood Hits	674	Shared Neighborhood Hits	117
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

CN094_HUMAN
NC score	0.046530 (rank : 832)	θ value	0.0431538 (rank : 145)
Query Neighborhood Hits	390	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H6D7, Q86T15, Q86T16, Q86U43, Q9NX59	Gene names	C14orf94
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf94.

TENS1_HUMAN
NC score	0.042804 (rank : 833)	θ value	0.279714 (rank : 219)
Query Neighborhood Hits	390	Target Neighborhood Hits	400	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

MIA2_MOUSE
NC score	0.039998 (rank : 834)	θ value	1.06291 (rank : 258)
Query Neighborhood Hits	390	Target Neighborhood Hits	109	Shared Neighborhood Hits	20
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

TNNT1_MOUSE
NC score	0.039337 (rank : 835)	θ value	2.36792 (rank : 302)
Query Neighborhood Hits	390	Target Neighborhood Hits	212	Shared Neighborhood Hits	64
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

C8AP2_HUMAN
NC score	0.039042 (rank : 836)	θ value	3.0926 (rank : 306)
Query Neighborhood Hits	390	Target Neighborhood Hits	548	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

BAZ2B_HUMAN
NC score	0.038150 (rank : 837)	θ value	6.88961 (rank : 352)
Query Neighborhood Hits	390	Target Neighborhood Hits	803	Shared Neighborhood Hits	101
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

SPFH1_HUMAN
NC score	0.037529 (rank : 838)	θ value	0.125558 (rank : 176)
Query Neighborhood Hits	390	Target Neighborhood Hits	91	Shared Neighborhood Hits	13
SwissProt Accessions	O75477	Gene names	SPFH1, C10orf69, KE04, KEO4
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 1 precursor (Protein KE04).

SPFH1_MOUSE
NC score	0.037094 (rank : 839)	θ value	0.163984 (rank : 190)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q91X78, Q8CIH7	Gene names	Spfh1, Keo4
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 1 precursor (KE04 protein homolog).

U2AFL_MOUSE
NC score	0.036992 (rank : 840)	θ value	8.99809 (rank : 390)
Query Neighborhood Hits	390	Target Neighborhood Hits	389	Shared Neighborhood Hits	73
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

SLK_HUMAN
NC score	0.036892 (rank : 841)	θ value	4.03905 (rank : 331)
Query Neighborhood Hits	390	Target Neighborhood Hits	1775	Shared Neighborhood Hits	174
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

C8AP2_MOUSE
NC score	0.036220 (rank : 842)	θ value	0.62314 (rank : 233)
Query Neighborhood Hits	390	Target Neighborhood Hits	405	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

DLG2_MOUSE
NC score	0.035514 (rank : 843)	θ value	4.03905 (rank : 322)
Query Neighborhood Hits	390	Target Neighborhood Hits	271	Shared Neighborhood Hits	70
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SEP11_MOUSE
NC score	0.035238 (rank : 844)	θ value	0.125558 (rank : 175)
Query Neighborhood Hits	390	Target Neighborhood Hits	300	Shared Neighborhood Hits	71
SwissProt Accessions	Q8C1B7, Q6P2K5, Q6P6I0	Gene names	Sept11, D5Ertd606e
Domain Architecture	No domain graphic available
Description	Septin-11.

SGOL1_MOUSE
NC score	0.034517 (rank : 845)	θ value	8.99809 (rank : 387)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q9CXH7, Q3U4K4, Q588H1, Q8BKW2	Gene names	Sgol1, Sgo1
Domain Architecture	No domain graphic available
Description	Shugoshin-like 1.

ATRX_HUMAN
NC score	0.032277 (rank : 846)	θ value	2.36792 (rank : 294)
Query Neighborhood Hits	390	Target Neighborhood Hits	842	Shared Neighborhood Hits	86
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

K1967_MOUSE
NC score	0.032239 (rank : 847)	θ value	0.47712 (rank : 228)
Query Neighborhood Hits	390	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

DLG2_HUMAN
NC score	0.030571 (rank : 848)	θ value	8.99809 (rank : 374)
Query Neighborhood Hits	390	Target Neighborhood Hits	279	Shared Neighborhood Hits	70
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DESM_HUMAN
NC score	0.029665 (rank : 849)	θ value	8.99809 (rank : 372)
Query Neighborhood Hits	390	Target Neighborhood Hits	495	Shared Neighborhood Hits	101
SwissProt Accessions	P17661, Q15787, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80	Gene names	DES
Domain Architecture
Description	Desmin.

DESM_MOUSE
NC score	0.029598 (rank : 850)	θ value	8.99809 (rank : 373)
Query Neighborhood Hits	390	Target Neighborhood Hits	498	Shared Neighborhood Hits	103
SwissProt Accessions	P31001	Gene names	Des
Domain Architecture
Description	Desmin.

BAT2_HUMAN
NC score	0.029360 (rank : 851)	θ value	3.0926 (rank : 305)
Query Neighborhood Hits	390	Target Neighborhood Hits	931	Shared Neighborhood Hits	47
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SRRM1_MOUSE
NC score	0.029052 (rank : 852)	θ value	2.36792 (rank : 301)
Query Neighborhood Hits	390	Target Neighborhood Hits	966	Shared Neighborhood Hits	48
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ANGP2_HUMAN
NC score	0.028965 (rank : 853)	θ value	3.0926 (rank : 304)
Query Neighborhood Hits	390	Target Neighborhood Hits	400	Shared Neighborhood Hits	81
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

SEP11_HUMAN
NC score	0.028815 (rank : 854)	θ value	1.81305 (rank : 293)
Query Neighborhood Hits	390	Target Neighborhood Hits	296	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NVA2, Q7L4N1	Gene names	SEPT11
Domain Architecture	No domain graphic available
Description	Septin-11.

PML_MOUSE
NC score	0.026742 (rank : 855)	θ value	3.0926 (rank : 315)
Query Neighborhood Hits	390	Target Neighborhood Hits	246	Shared Neighborhood Hits	22
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

SPFH2_MOUSE
NC score	0.025624 (rank : 856)	θ value	6.88961 (rank : 365)
Query Neighborhood Hits	390	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BFZ9, Q8BML8	Gene names	Spfh2
Domain Architecture	No domain graphic available
Description	SPFH domain-containing protein 2 precursor.

SNX13_MOUSE
NC score	0.024767 (rank : 857)	θ value	0.21417 (rank : 205)
Query Neighborhood Hits	390	Target Neighborhood Hits	86	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

PRP4B_HUMAN
NC score	0.024025 (rank : 858)	θ value	1.06291 (rank : 262)
Query Neighborhood Hits	390	Target Neighborhood Hits	1030	Shared Neighborhood Hits	75
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
NC score	0.023866 (rank : 859)	θ value	2.36792 (rank : 299)
Query Neighborhood Hits	390	Target Neighborhood Hits	1040	Shared Neighborhood Hits	73
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

TIP1_MOUSE
NC score	0.023865 (rank : 860)	θ value	8.99809 (rank : 389)
Query Neighborhood Hits	390	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CR47, Q8BHQ6, Q8BHT0, Q9CRQ0, Q9CS34, Q9CYK0, Q9JKF9	Gene names	Tinp1
Domain Architecture
Description	TGF-beta-inducible nuclear protein 1 (L-name-related protein 42) (LNR42).

COFA1_MOUSE
NC score	0.023699 (rank : 861)	θ value	0.00390308 (rank : 112)
Query Neighborhood Hits	390	Target Neighborhood Hits	305	Shared Neighborhood Hits	9
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

AAK1_HUMAN
NC score	0.023243 (rank : 862)	θ value	0.0563607 (rank : 150)
Query Neighborhood Hits	390	Target Neighborhood Hits	1077	Shared Neighborhood Hits	59
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
NC score	0.022274 (rank : 863)	θ value	0.00509761 (rank : 115)
Query Neighborhood Hits	390	Target Neighborhood Hits	1051	Shared Neighborhood Hits	52
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

ZRAN1_HUMAN
NC score	0.022083 (rank : 864)	θ value	5.27518 (rank : 351)
Query Neighborhood Hits	390	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGI0	Gene names	ZRANB1, TRABID
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 1 (Protein TRABID).

TR13B_HUMAN
NC score	0.021427 (rank : 865)	θ value	1.38821 (rank : 277)
Query Neighborhood Hits	390	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O14836, Q7Z6F5	Gene names	TNFRSF13B, TACI
Domain Architecture	No domain graphic available
Description	Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD267 antigen).

TIP1_HUMAN
NC score	0.021175 (rank : 866)	θ value	5.27518 (rank : 349)
Query Neighborhood Hits	390	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	O95478	Gene names	TINP1
Domain Architecture
Description	TGF-beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1).

MAML1_HUMAN
NC score	0.018733 (rank : 867)	θ value	0.62314 (rank : 237)
Query Neighborhood Hits	390	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

DVL3_HUMAN
NC score	0.018427 (rank : 868)	θ value	0.279714 (rank : 211)
Query Neighborhood Hits	390	Target Neighborhood Hits	194	Shared Neighborhood Hits	14
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

E2AK4_HUMAN
NC score	0.018252 (rank : 869)	θ value	1.06291 (rank : 256)
Query Neighborhood Hits	390	Target Neighborhood Hits	1012	Shared Neighborhood Hits	77
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SNX13_HUMAN
NC score	0.018128 (rank : 870)	θ value	5.27518 (rank : 348)
Query Neighborhood Hits	390	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

FOXP2_HUMAN
NC score	0.018118 (rank : 871)	θ value	3.0926 (rank : 309)
Query Neighborhood Hits	390	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

KIF2C_HUMAN
NC score	0.017850 (rank : 872)	θ value	0.279714 (rank : 212)
Query Neighborhood Hits	390	Target Neighborhood Hits	138	Shared Neighborhood Hits	18
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

MILK2_HUMAN
NC score	0.017814 (rank : 873)	θ value	6.88961 (rank : 362)
Query Neighborhood Hits	390	Target Neighborhood Hits	457	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

NSD1_MOUSE
NC score	0.017170 (rank : 874)	θ value	0.813845 (rank : 248)
Query Neighborhood Hits	390	Target Neighborhood Hits	472	Shared Neighborhood Hits	24
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

RGS3_MOUSE
NC score	0.016900 (rank : 875)	θ value	8.99809 (rank : 386)
Query Neighborhood Hits	390	Target Neighborhood Hits	1621	Shared Neighborhood Hits	60
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

YYAP1_HUMAN
NC score	0.016652 (rank : 876)	θ value	1.38821 (rank : 279)
Query Neighborhood Hits	390	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H869, Q5VYZ4, Q5VYZ7, Q7L4C3, Q7L5E2, Q8IXA6, Q8TEW5, Q8TF04, Q96HB6, Q9BQ64, Q9NV84	Gene names	YY1AP1, HCCA2, YY1AP
Domain Architecture	No domain graphic available
Description	YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2).

P73L_HUMAN
NC score	0.016471 (rank : 877)	θ value	0.813845 (rank : 249)
Query Neighborhood Hits	390	Target Neighborhood Hits	102	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H3D4, O75080, O75195, O75922, O76078, Q6VEG2, Q6VEG3, Q6VEG4, Q6VFJ1, Q6VFJ2, Q6VFJ3, Q6VH20, Q7LDI3, Q7LDI4, Q7LDI5, Q96KR0, Q9H3D2, Q9H3D3, Q9H3P8, Q9NPH7, Q9P1B4, Q9P1B5, Q9P1B6, Q9P1B7, Q9UBV9, Q9UE10, Q9UP26, Q9UP27, Q9UP28, Q9UP74	Gene names	TP73L, KET, P63, P73H, P73L
Domain Architecture	No domain graphic available
Description	Tumor protein p73-like (p73L) (p63) (Tumor protein 63) (TP63) (p51) (p40) (Keratinocyte transcription factor KET) (Chronic ulcerative stomatitis protein) (CUSP).

ORC1_MOUSE
NC score	0.016429 (rank : 878)	θ value	3.0926 (rank : 312)
Query Neighborhood Hits	390	Target Neighborhood Hits	65	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z1N2	Gene names	Orc1l, Orc1
Domain Architecture
Description	Origin recognition complex subunit 1.

TRI25_HUMAN
NC score	0.016209 (rank : 879)	θ value	1.38821 (rank : 278)
Query Neighborhood Hits	390	Target Neighborhood Hits	472	Shared Neighborhood Hits	62
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

LEUK_HUMAN
NC score	0.014357 (rank : 880)	θ value	1.81305 (rank : 285)
Query Neighborhood Hits	390	Target Neighborhood Hits	213	Shared Neighborhood Hits	8
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

CDT1_MOUSE
NC score	0.013669 (rank : 881)	θ value	3.0926 (rank : 308)
Query Neighborhood Hits	390	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

DEN2A_HUMAN
NC score	0.013404 (rank : 882)	θ value	0.365318 (rank : 221)
Query Neighborhood Hits	390	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

HORN_HUMAN
NC score	0.013269 (rank : 883)	θ value	3.0926 (rank : 310)
Query Neighborhood Hits	390	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

MAK_HUMAN
NC score	0.013267 (rank : 884)	θ value	8.99809 (rank : 379)
Query Neighborhood Hits	390	Target Neighborhood Hits	857	Shared Neighborhood Hits	43
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAST4_HUMAN
NC score	0.012462 (rank : 885)	θ value	1.38821 (rank : 271)
Query Neighborhood Hits	390	Target Neighborhood Hits	1804	Shared Neighborhood Hits	84
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

DVL3_MOUSE
NC score	0.012282 (rank : 886)	θ value	4.03905 (rank : 323)
Query Neighborhood Hits	390	Target Neighborhood Hits	198	Shared Neighborhood Hits	12
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

KIF2C_MOUSE
NC score	0.011985 (rank : 887)	θ value	4.03905 (rank : 326)
Query Neighborhood Hits	390	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q922S8	Gene names	Kif2c
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK).

TTC4_MOUSE
NC score	0.011110 (rank : 888)	θ value	5.27518 (rank : 350)
Query Neighborhood Hits	390	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3H9	Gene names	Ttc4
Domain Architecture
Description	Tetratricopeptide repeat protein 4 (TPR repeat protein 4).

PSMD9_MOUSE
NC score	0.010985 (rank : 889)	θ value	5.27518 (rank : 346)
Query Neighborhood Hits	390	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

WEE1B_HUMAN
NC score	0.010901 (rank : 890)	θ value	3.0926 (rank : 320)
Query Neighborhood Hits	390	Target Neighborhood Hits	836	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

SMG7_HUMAN
NC score	0.010214 (rank : 891)	θ value	4.03905 (rank : 332)
Query Neighborhood Hits	390	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q92540, Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2	Gene names	SMG7, C1orf16, EST1C, KIAA0250
Domain Architecture
Description	Protein SMG7 (SMG-7 homolog) (EST1-like protein C).

ITIH2_HUMAN
NC score	0.009114 (rank : 892)	θ value	6.88961 (rank : 360)
Query Neighborhood Hits	390	Target Neighborhood Hits	29	Shared Neighborhood Hits	6
SwissProt Accessions	P19823, Q14659, Q15484	Gene names	ITIH2, IGHEP2
Domain Architecture
Description	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP).

K1024_MOUSE
NC score	0.008395 (rank : 893)	θ value	5.27518 (rank : 339)
Query Neighborhood Hits	390	Target Neighborhood Hits	57	Shared Neighborhood Hits	7
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

OSBL6_HUMAN
NC score	0.007998 (rank : 894)	θ value	2.36792 (rank : 298)
Query Neighborhood Hits	390	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

POLK_HUMAN
NC score	0.007967 (rank : 895)	θ value	8.99809 (rank : 383)
Query Neighborhood Hits	390	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

PI51B_HUMAN
NC score	0.006423 (rank : 896)	θ value	8.99809 (rank : 381)
Query Neighborhood Hits	390	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14986, P78518, P78519, Q5T5K6, Q5T5K8, Q5T5K9, Q5VZ00, Q7KYT5, Q8NHQ5, Q92749	Gene names	PIP5K1B, STM7
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I beta) (PtdIns(4)P-5- kinase beta) (PIP5KIbeta) (Type I phosphatidylinositol-4-phosphate 5- kinase beta) (Protein STM-7).

1433F_HUMAN
NC score	0.004534 (rank : 897)	θ value	5.27518 (rank : 335)
Query Neighborhood Hits	390	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	Q04917	Gene names	YWHAH, YWHA1
Domain Architecture
Description	14-3-3 protein eta (Protein AS1).

1433F_MOUSE
NC score	0.003721 (rank : 898)	θ value	8.99809 (rank : 367)
Query Neighborhood Hits	390	Target Neighborhood Hits	37	Shared Neighborhood Hits	5
SwissProt Accessions	P68510, P11576, P70198, Q3TGZ9	Gene names	Ywhah
Domain Architecture	No domain graphic available
Description	14-3-3 protein eta.

PARPT_HUMAN
NC score	0.003604 (rank : 899)	θ value	8.99809 (rank : 380)
Query Neighborhood Hits	390	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z3E1, Q68CY9, Q86VP4, Q9Y4P7	Gene names	TIPARP, PARP7
Domain Architecture	No domain graphic available
Description	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7).

ZEP1_HUMAN
NC score	-0.006182 (rank : 900)	θ value	3.0926 (rank : 321)
Query Neighborhood Hits	390	Target Neighborhood Hits	1036	Shared Neighborhood Hits	13
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).