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Network neighborhood for query Sequence : HCLS1_MOUSE

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HCLS1_MOUSE
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HCLS1_HUMAN
θ value	0 (rank : 1)	NC score	0.965799 (rank : 2)
Query Neighborhood Hits	329	Target Neighborhood Hits	358	Shared Neighborhood Hits	221
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	329	Target Neighborhood Hits	329	Shared Neighborhood Hits	329
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_MOUSE
θ value	6.24247e-110 (rank : 3)	NC score	0.941511 (rank : 3)
Query Neighborhood Hits	329	Target Neighborhood Hits	292	Shared Neighborhood Hits	181
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
θ value	9.056e-93 (rank : 4)	NC score	0.937638 (rank : 4)
Query Neighborhood Hits	329	Target Neighborhood Hits	269	Shared Neighborhood Hits	178
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DBNL_MOUSE
θ value	3.07829e-16 (rank : 5)	NC score	0.691198 (rank : 6)
Query Neighborhood Hits	329	Target Neighborhood Hits	306	Shared Neighborhood Hits	157
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DBNL_HUMAN
θ value	5.25075e-16 (rank : 6)	NC score	0.699813 (rank : 5)
Query Neighborhood Hits	329	Target Neighborhood Hits	244	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ITSN1_HUMAN
θ value	7.34386e-10 (rank : 7)	NC score	0.405656 (rank : 87)
Query Neighborhood Hits	329	Target Neighborhood Hits	1757	Shared Neighborhood Hits	229
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	4.76016e-09 (rank : 8)	NC score	0.405612 (rank : 88)
Query Neighborhood Hits	329	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SH3G2_HUMAN
θ value	1.06045e-08 (rank : 9)	NC score	0.618187 (rank : 14)
Query Neighborhood Hits	329	Target Neighborhood Hits	324	Shared Neighborhood Hits	169
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3K1_HUMAN
θ value	1.80886e-08 (rank : 10)	NC score	0.656587 (rank : 8)
Query Neighborhood Hits	329	Target Neighborhood Hits	341	Shared Neighborhood Hits	175
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	2.36244e-08 (rank : 11)	NC score	0.657440 (rank : 7)
Query Neighborhood Hits	329	Target Neighborhood Hits	332	Shared Neighborhood Hits	176
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ITSN2_HUMAN
θ value	6.87365e-08 (rank : 12)	NC score	0.423297 (rank : 78)
Query Neighborhood Hits	329	Target Neighborhood Hits	1173	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MYO1E_HUMAN
θ value	8.97725e-08 (rank : 13)	NC score	0.268959 (rank : 123)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	169
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

PACN2_MOUSE
θ value	8.97725e-08 (rank : 14)	NC score	0.581095 (rank : 27)
Query Neighborhood Hits	329	Target Neighborhood Hits	382	Shared Neighborhood Hits	172
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_MOUSE
θ value	8.97725e-08 (rank : 15)	NC score	0.609090 (rank : 18)
Query Neighborhood Hits	329	Target Neighborhood Hits	319	Shared Neighborhood Hits	168
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ITSN2_MOUSE
θ value	1.17247e-07 (rank : 16)	NC score	0.403431 (rank : 89)
Query Neighborhood Hits	329	Target Neighborhood Hits	1371	Shared Neighborhood Hits	198
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SH3G3_MOUSE
θ value	1.53129e-07 (rank : 17)	NC score	0.617212 (rank : 15)
Query Neighborhood Hits	329	Target Neighborhood Hits	236	Shared Neighborhood Hits	164
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

OSTF1_MOUSE
θ value	2.61198e-07 (rank : 18)	NC score	0.471239 (rank : 68)
Query Neighborhood Hits	329	Target Neighborhood Hits	467	Shared Neighborhood Hits	173
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CD2AP_MOUSE
θ value	3.41135e-07 (rank : 19)	NC score	0.649646 (rank : 9)
Query Neighborhood Hits	329	Target Neighborhood Hits	336	Shared Neighborhood Hits	186
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

MYO1F_HUMAN
θ value	3.41135e-07 (rank : 20)	NC score	0.277860 (rank : 118)
Query Neighborhood Hits	329	Target Neighborhood Hits	275	Shared Neighborhood Hits	168
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	4.45536e-07 (rank : 21)	NC score	0.276864 (rank : 119)
Query Neighborhood Hits	329	Target Neighborhood Hits	262	Shared Neighborhood Hits	166
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PACN2_HUMAN
θ value	4.45536e-07 (rank : 22)	NC score	0.581167 (rank : 26)
Query Neighborhood Hits	329	Target Neighborhood Hits	339	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_HUMAN
θ value	5.81887e-07 (rank : 23)	NC score	0.566824 (rank : 32)
Query Neighborhood Hits	329	Target Neighborhood Hits	320	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	5.81887e-07 (rank : 24)	NC score	0.571818 (rank : 29)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	166
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3G3_HUMAN
θ value	9.92553e-07 (rank : 25)	NC score	0.607428 (rank : 20)
Query Neighborhood Hits	329	Target Neighborhood Hits	222	Shared Neighborhood Hits	161
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

LASP1_HUMAN
θ value	1.29631e-06 (rank : 26)	NC score	0.541444 (rank : 41)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	147
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	1.29631e-06 (rank : 27)	NC score	0.537094 (rank : 44)
Query Neighborhood Hits	329	Target Neighborhood Hits	297	Shared Neighborhood Hits	146
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SH3G1_HUMAN
θ value	1.29631e-06 (rank : 28)	NC score	0.587454 (rank : 23)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	1.29631e-06 (rank : 29)	NC score	0.590441 (rank : 22)
Query Neighborhood Hits	329	Target Neighborhood Hits	291	Shared Neighborhood Hits	165
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

ABI1_MOUSE
θ value	1.69304e-06 (rank : 30)	NC score	0.610452 (rank : 17)
Query Neighborhood Hits	329	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	1.69304e-06 (rank : 31)	NC score	0.624753 (rank : 11)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	188
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	1.69304e-06 (rank : 32)	NC score	0.624261 (rank : 12)
Query Neighborhood Hits	329	Target Neighborhood Hits	266	Shared Neighborhood Hits	173
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI1_HUMAN
θ value	2.21117e-06 (rank : 33)	NC score	0.593366 (rank : 21)
Query Neighborhood Hits	329	Target Neighborhood Hits	257	Shared Neighborhood Hits	170
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

RHG04_HUMAN
θ value	2.88788e-06 (rank : 34)	NC score	0.354895 (rank : 101)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

OSTF1_HUMAN
θ value	3.77169e-06 (rank : 35)	NC score	0.472896 (rank : 67)
Query Neighborhood Hits	329	Target Neighborhood Hits	466	Shared Neighborhood Hits	172
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PLCG1_MOUSE
θ value	3.77169e-06 (rank : 36)	NC score	0.412578 (rank : 83)
Query Neighborhood Hits	329	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAC_HUMAN
θ value	3.77169e-06 (rank : 37)	NC score	0.572387 (rank : 28)
Query Neighborhood Hits	329	Target Neighborhood Hits	276	Shared Neighborhood Hits	160
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

M3KL4_HUMAN
θ value	4.92598e-06 (rank : 38)	NC score	0.186990 (rank : 145)
Query Neighborhood Hits	329	Target Neighborhood Hits	1087	Shared Neighborhood Hits	183
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CD2AP_HUMAN
θ value	6.43352e-06 (rank : 39)	NC score	0.635209 (rank : 10)
Query Neighborhood Hits	329	Target Neighborhood Hits	315	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NEBL_HUMAN
θ value	6.43352e-06 (rank : 40)	NC score	0.483495 (rank : 62)
Query Neighborhood Hits	329	Target Neighborhood Hits	457	Shared Neighborhood Hits	156
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PACN3_HUMAN
θ value	6.43352e-06 (rank : 41)	NC score	0.532000 (rank : 48)
Query Neighborhood Hits	329	Target Neighborhood Hits	385	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	6.43352e-06 (rank : 42)	NC score	0.538400 (rank : 43)
Query Neighborhood Hits	329	Target Neighborhood Hits	380	Shared Neighborhood Hits	163
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NCK2_HUMAN
θ value	8.40245e-06 (rank : 43)	NC score	0.534598 (rank : 45)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBU_HUMAN
θ value	8.40245e-06 (rank : 44)	NC score	0.436733 (rank : 76)
Query Neighborhood Hits	329	Target Neighborhood Hits	420	Shared Neighborhood Hits	161
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

DNMBP_MOUSE
θ value	1.43324e-05 (rank : 45)	NC score	0.497481 (rank : 59)
Query Neighborhood Hits	329	Target Neighborhood Hits	435	Shared Neighborhood Hits	190
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP2_HUMAN
θ value	1.43324e-05 (rank : 46)	NC score	0.552469 (rank : 36)
Query Neighborhood Hits	329	Target Neighborhood Hits	304	Shared Neighborhood Hits	178
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_HUMAN
θ value	1.43324e-05 (rank : 47)	NC score	0.548992 (rank : 37)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.43324e-05 (rank : 48)	NC score	0.548685 (rank : 38)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAM1_HUMAN
θ value	1.43324e-05 (rank : 49)	NC score	0.567195 (rank : 31)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	174
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

GRAP2_MOUSE
θ value	1.87187e-05 (rank : 50)	NC score	0.555904 (rank : 35)
Query Neighborhood Hits	329	Target Neighborhood Hits	297	Shared Neighborhood Hits	175
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PLCG1_HUMAN
θ value	1.87187e-05 (rank : 51)	NC score	0.395283 (rank : 92)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

STAM1_MOUSE
θ value	1.87187e-05 (rank : 52)	NC score	0.564869 (rank : 33)
Query Neighborhood Hits	329	Target Neighborhood Hits	273	Shared Neighborhood Hits	175
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG7_HUMAN
θ value	2.44474e-05 (rank : 53)	NC score	0.516881 (rank : 54)
Query Neighborhood Hits	329	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

M3K11_HUMAN
θ value	3.19293e-05 (rank : 54)	NC score	0.171904 (rank : 153)
Query Neighborhood Hits	329	Target Neighborhood Hits	1136	Shared Neighborhood Hits	188
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

STAC_MOUSE
θ value	3.19293e-05 (rank : 55)	NC score	0.556842 (rank : 34)
Query Neighborhood Hits	329	Target Neighborhood Hits	268	Shared Neighborhood Hits	159
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

AHI1_MOUSE
θ value	4.1701e-05 (rank : 56)	NC score	0.409294 (rank : 84)
Query Neighborhood Hits	329	Target Neighborhood Hits	496	Shared Neighborhood Hits	172
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG7_MOUSE
θ value	4.1701e-05 (rank : 57)	NC score	0.521740 (rank : 53)
Query Neighborhood Hits	329	Target Neighborhood Hits	396	Shared Neighborhood Hits	170
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VINEX_MOUSE
θ value	4.1701e-05 (rank : 58)	NC score	0.608898 (rank : 19)
Query Neighborhood Hits	329	Target Neighborhood Hits	286	Shared Neighborhood Hits	180
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF2_HUMAN
θ value	5.44631e-05 (rank : 59)	NC score	0.623903 (rank : 13)
Query Neighborhood Hits	329	Target Neighborhood Hits	229	Shared Neighborhood Hits	154
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SPTA1_MOUSE
θ value	5.44631e-05 (rank : 60)	NC score	0.247137 (rank : 132)
Query Neighborhood Hits	329	Target Neighborhood Hits	675	Shared Neighborhood Hits	158
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

GRAP_HUMAN
θ value	7.1131e-05 (rank : 61)	NC score	0.523953 (rank : 51)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	174
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SPTA2_HUMAN
θ value	7.1131e-05 (rank : 62)	NC score	0.254516 (rank : 131)
Query Neighborhood Hits	329	Target Neighborhood Hits	888	Shared Neighborhood Hits	169
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRGP2_HUMAN
θ value	7.1131e-05 (rank : 63)	NC score	0.314671 (rank : 108)
Query Neighborhood Hits	329	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

VAV_MOUSE
θ value	7.1131e-05 (rank : 64)	NC score	0.445006 (rank : 71)
Query Neighborhood Hits	329	Target Neighborhood Hits	430	Shared Neighborhood Hits	168
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

M3K9_HUMAN
θ value	9.29e-05 (rank : 65)	NC score	0.164099 (rank : 163)
Query Neighborhood Hits	329	Target Neighborhood Hits	1123	Shared Neighborhood Hits	181
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

SRBS1_MOUSE
θ value	9.29e-05 (rank : 66)	NC score	0.587034 (rank : 24)
Query Neighborhood Hits	329	Target Neighborhood Hits	409	Shared Neighborhood Hits	196
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRGP2_MOUSE
θ value	9.29e-05 (rank : 67)	NC score	0.319181 (rank : 107)
Query Neighborhood Hits	329	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAM2_MOUSE
θ value	9.29e-05 (rank : 68)	NC score	0.545487 (rank : 40)
Query Neighborhood Hits	329	Target Neighborhood Hits	285	Shared Neighborhood Hits	167
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

VAV_HUMAN
θ value	9.29e-05 (rank : 69)	NC score	0.443618 (rank : 72)
Query Neighborhood Hits	329	Target Neighborhood Hits	452	Shared Neighborhood Hits	170
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VINEX_HUMAN
θ value	9.29e-05 (rank : 70)	NC score	0.611446 (rank : 16)
Query Neighborhood Hits	329	Target Neighborhood Hits	270	Shared Neighborhood Hits	178
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

FGR_MOUSE
θ value	0.000121331 (rank : 71)	NC score	0.165931 (rank : 160)
Query Neighborhood Hits	329	Target Neighborhood Hits	1069	Shared Neighborhood Hits	171
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NCK1_HUMAN
θ value	0.000121331 (rank : 72)	NC score	0.533026 (rank : 47)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	172
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRBS1_HUMAN
θ value	0.000121331 (rank : 73)	NC score	0.582053 (rank : 25)
Query Neighborhood Hits	329	Target Neighborhood Hits	396	Shared Neighborhood Hits	190
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM2_HUMAN
θ value	0.000121331 (rank : 74)	NC score	0.534574 (rank : 46)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	173
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GRAP_MOUSE
θ value	0.000158464 (rank : 75)	NC score	0.523065 (rank : 52)
Query Neighborhood Hits	329	Target Neighborhood Hits	309	Shared Neighborhood Hits	173
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCF4_HUMAN
θ value	0.000158464 (rank : 76)	NC score	0.547347 (rank : 39)
Query Neighborhood Hits	329	Target Neighborhood Hits	161	Shared Neighborhood Hits	127
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	0.000158464 (rank : 77)	NC score	0.570677 (rank : 30)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	137
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

AHI1_HUMAN
θ value	0.00020696 (rank : 78)	NC score	0.409007 (rank : 85)
Query Neighborhood Hits	329	Target Neighborhood Hits	537	Shared Neighborhood Hits	172
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CT032_HUMAN
θ value	0.00020696 (rank : 79)	NC score	0.479917 (rank : 63)
Query Neighborhood Hits	329	Target Neighborhood Hits	235	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PPIP1_MOUSE
θ value	0.00020696 (rank : 80)	NC score	0.538407 (rank : 42)
Query Neighborhood Hits	329	Target Neighborhood Hits	377	Shared Neighborhood Hits	175
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SPTA1_HUMAN
θ value	0.00020696 (rank : 81)	NC score	0.240506 (rank : 134)
Query Neighborhood Hits	329	Target Neighborhood Hits	748	Shared Neighborhood Hits	165
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAC3_HUMAN
θ value	0.00020696 (rank : 82)	NC score	0.515317 (rank : 57)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.00020696 (rank : 83)	NC score	0.516781 (rank : 55)
Query Neighborhood Hits	329	Target Neighborhood Hits	232	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CASL_HUMAN
θ value	0.000270298 (rank : 84)	NC score	0.413350 (rank : 81)
Query Neighborhood Hits	329	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.000270298 (rank : 85)	NC score	0.413119 (rank : 82)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	146
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

DNMBP_HUMAN
θ value	0.000270298 (rank : 86)	NC score	0.503883 (rank : 58)
Query Neighborhood Hits	329	Target Neighborhood Hits	413	Shared Neighborhood Hits	183
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

BCAR1_HUMAN
θ value	0.00035302 (rank : 87)	NC score	0.440587 (rank : 74)
Query Neighborhood Hits	329	Target Neighborhood Hits	554	Shared Neighborhood Hits	201
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.000461057 (rank : 88)	NC score	0.442069 (rank : 73)
Query Neighborhood Hits	329	Target Neighborhood Hits	438	Shared Neighborhood Hits	191
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

VAV2_HUMAN
θ value	0.000461057 (rank : 89)	NC score	0.417586 (rank : 80)
Query Neighborhood Hits	329	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.000461057 (rank : 90)	NC score	0.418801 (rank : 79)
Query Neighborhood Hits	329	Target Neighborhood Hits	456	Shared Neighborhood Hits	166
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

M3K10_HUMAN
θ value	0.000602161 (rank : 91)	NC score	0.150834 (rank : 175)
Query Neighborhood Hits	329	Target Neighborhood Hits	1071	Shared Neighborhood Hits	163
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ARHG6_HUMAN
θ value	0.000786445 (rank : 92)	NC score	0.484666 (rank : 61)
Query Neighborhood Hits	329	Target Neighborhood Hits	376	Shared Neighborhood Hits	166
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.000786445 (rank : 93)	NC score	0.489655 (rank : 60)
Query Neighborhood Hits	329	Target Neighborhood Hits	394	Shared Neighborhood Hits	167
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG9_HUMAN
θ value	0.000786445 (rank : 94)	NC score	0.363462 (rank : 100)
Query Neighborhood Hits	329	Target Neighborhood Hits	235	Shared Neighborhood Hits	143
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.000786445 (rank : 95)	NC score	0.366040 (rank : 99)
Query Neighborhood Hits	329	Target Neighborhood Hits	234	Shared Neighborhood Hits	143
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

RGS3_MOUSE
θ value	0.000786445 (rank : 96)	NC score	0.086004 (rank : 279)
Query Neighborhood Hits	329	Target Neighborhood Hits	1621	Shared Neighborhood Hits	130
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SRGP1_HUMAN
θ value	0.000786445 (rank : 97)	NC score	0.299228 (rank : 111)
Query Neighborhood Hits	329	Target Neighborhood Hits	390	Shared Neighborhood Hits	143
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

PPIP1_HUMAN
θ value	0.00102713 (rank : 98)	NC score	0.528226 (rank : 49)
Query Neighborhood Hits	329	Target Neighborhood Hits	389	Shared Neighborhood Hits	173
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PLCG2_HUMAN
θ value	0.00134147 (rank : 99)	NC score	0.388439 (rank : 94)
Query Neighborhood Hits	329	Target Neighborhood Hits	280	Shared Neighborhood Hits	148
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV3_HUMAN
θ value	0.00134147 (rank : 100)	NC score	0.397852 (rank : 91)
Query Neighborhood Hits	329	Target Neighborhood Hits	398	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

DOCK1_HUMAN
θ value	0.00228821 (rank : 101)	NC score	0.210690 (rank : 140)
Query Neighborhood Hits	329	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

VAV3_MOUSE
θ value	0.00228821 (rank : 102)	NC score	0.390000 (rank : 93)
Query Neighborhood Hits	329	Target Neighborhood Hits	404	Shared Neighborhood Hits	169
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

FGR_HUMAN
θ value	0.00298849 (rank : 103)	NC score	0.171420 (rank : 154)
Query Neighborhood Hits	329	Target Neighborhood Hits	1067	Shared Neighborhood Hits	169
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TCGAP_HUMAN
θ value	0.00298849 (rank : 104)	NC score	0.243088 (rank : 133)
Query Neighborhood Hits	329	Target Neighborhood Hits	872	Shared Neighborhood Hits	170
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	0.00298849 (rank : 105)	NC score	0.258436 (rank : 128)
Query Neighborhood Hits	329	Target Neighborhood Hits	409	Shared Neighborhood Hits	132
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SRC_HUMAN
θ value	0.00390308 (rank : 106)	NC score	0.164621 (rank : 162)
Query Neighborhood Hits	329	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

WNK2_HUMAN
θ value	0.00390308 (rank : 107)	NC score	0.050956 (rank : 421)
Query Neighborhood Hits	329	Target Neighborhood Hits	1407	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ARHG4_HUMAN
θ value	0.00509761 (rank : 108)	NC score	0.379419 (rank : 95)
Query Neighborhood Hits	329	Target Neighborhood Hits	242	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SNX18_HUMAN
θ value	0.00509761 (rank : 109)	NC score	0.367259 (rank : 98)
Query Neighborhood Hits	329	Target Neighborhood Hits	207	Shared Neighborhood Hits	124
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.00509761 (rank : 110)	NC score	0.370693 (rank : 97)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ASPP1_HUMAN
θ value	0.00665767 (rank : 111)	NC score	0.284126 (rank : 117)
Query Neighborhood Hits	329	Target Neighborhood Hits	956	Shared Neighborhood Hits	180
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CRKL_HUMAN
θ value	0.00665767 (rank : 112)	NC score	0.474768 (rank : 66)
Query Neighborhood Hits	329	Target Neighborhood Hits	313	Shared Neighborhood Hits	166
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

FNBP2_HUMAN
θ value	0.00665767 (rank : 113)	NC score	0.298000 (rank : 113)
Query Neighborhood Hits	329	Target Neighborhood Hits	432	Shared Neighborhood Hits	153
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

NFH_MOUSE
θ value	0.00665767 (rank : 114)	NC score	0.045497 (rank : 438)
Query Neighborhood Hits	329	Target Neighborhood Hits	2247	Shared Neighborhood Hits	132
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ASPP1_MOUSE
θ value	0.00869519 (rank : 115)	NC score	0.286896 (rank : 116)
Query Neighborhood Hits	329	Target Neighborhood Hits	1244	Shared Neighborhood Hits	221
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CRKL_MOUSE
θ value	0.0113563 (rank : 116)	NC score	0.465228 (rank : 69)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	162
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RUSC1_MOUSE
θ value	0.0113563 (rank : 117)	NC score	0.324641 (rank : 106)
Query Neighborhood Hits	329	Target Neighborhood Hits	206	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

YES_MOUSE
θ value	0.0113563 (rank : 118)	NC score	0.167138 (rank : 158)
Query Neighborhood Hits	329	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ABI3_MOUSE
θ value	0.0148317 (rank : 119)	NC score	0.525935 (rank : 50)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CN155_HUMAN
θ value	0.0148317 (rank : 120)	NC score	0.094793 (rank : 248)
Query Neighborhood Hits	329	Target Neighborhood Hits	385	Shared Neighborhood Hits	54
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

FRK_HUMAN
θ value	0.0193708 (rank : 121)	NC score	0.138602 (rank : 188)
Query Neighborhood Hits	329	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

AMPH_HUMAN
θ value	0.0252991 (rank : 122)	NC score	0.204309 (rank : 141)
Query Neighborhood Hits	329	Target Neighborhood Hits	455	Shared Neighborhood Hits	119
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

DDEF1_MOUSE
θ value	0.0252991 (rank : 123)	NC score	0.265370 (rank : 124)
Query Neighborhood Hits	329	Target Neighborhood Hits	592	Shared Neighborhood Hits	158
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FYN_HUMAN
θ value	0.0252991 (rank : 124)	NC score	0.168033 (rank : 157)
Query Neighborhood Hits	329	Target Neighborhood Hits	1078	Shared Neighborhood Hits	174
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.0252991 (rank : 125)	NC score	0.171066 (rank : 155)
Query Neighborhood Hits	329	Target Neighborhood Hits	1073	Shared Neighborhood Hits	174
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ABI3_HUMAN
θ value	0.0330416 (rank : 126)	NC score	0.515443 (rank : 56)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CSK_HUMAN
θ value	0.0330416 (rank : 127)	NC score	0.122873 (rank : 203)
Query Neighborhood Hits	329	Target Neighborhood Hits	1009	Shared Neighborhood Hits	133
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	0.0330416 (rank : 128)	NC score	0.122913 (rank : 202)
Query Neighborhood Hits	329	Target Neighborhood Hits	1009	Shared Neighborhood Hits	133
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

RHG26_HUMAN
θ value	0.0330416 (rank : 129)	NC score	0.287123 (rank : 115)
Query Neighborhood Hits	329	Target Neighborhood Hits	281	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

YES_HUMAN
θ value	0.0330416 (rank : 130)	NC score	0.165418 (rank : 161)
Query Neighborhood Hits	329	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DLG5_HUMAN
θ value	0.0431538 (rank : 131)	NC score	0.045310 (rank : 439)
Query Neighborhood Hits	329	Target Neighborhood Hits	1088	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ERBB4_HUMAN
θ value	0.0431538 (rank : 132)	NC score	0.052124 (rank : 410)
Query Neighborhood Hits	329	Target Neighborhood Hits	910	Shared Neighborhood Hits	44
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

NOXO1_HUMAN
θ value	0.0431538 (rank : 133)	NC score	0.270834 (rank : 122)
Query Neighborhood Hits	329	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	0.0431538 (rank : 134)	NC score	0.352644 (rank : 102)
Query Neighborhood Hits	329	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ZAN_HUMAN
θ value	0.0431538 (rank : 135)	NC score	0.038303 (rank : 458)
Query Neighborhood Hits	329	Target Neighborhood Hits	679	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

HCK_HUMAN
θ value	0.0563607 (rank : 136)	NC score	0.144108 (rank : 186)
Query Neighborhood Hits	329	Target Neighborhood Hits	1035	Shared Neighborhood Hits	168
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SHAN1_HUMAN
θ value	0.0563607 (rank : 137)	NC score	0.178177 (rank : 151)
Query Neighborhood Hits	329	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	0.0563607 (rank : 138)	NC score	0.222839 (rank : 137)
Query Neighborhood Hits	329	Target Neighborhood Hits	446	Shared Neighborhood Hits	121
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

EFS_HUMAN
θ value	0.0736092 (rank : 139)	NC score	0.401860 (rank : 90)
Query Neighborhood Hits	329	Target Neighborhood Hits	348	Shared Neighborhood Hits	173
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	0.0736092 (rank : 140)	NC score	0.406499 (rank : 86)
Query Neighborhood Hits	329	Target Neighborhood Hits	389	Shared Neighborhood Hits	176
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MDC1_HUMAN
θ value	0.0736092 (rank : 141)	NC score	0.088274 (rank : 270)
Query Neighborhood Hits	329	Target Neighborhood Hits	1446	Shared Neighborhood Hits	117
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NCF1_HUMAN
θ value	0.0736092 (rank : 142)	NC score	0.477534 (rank : 65)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	144
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

P85B_HUMAN
θ value	0.0736092 (rank : 143)	NC score	0.145097 (rank : 183)
Query Neighborhood Hits	329	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SHLB1_HUMAN
θ value	0.0736092 (rank : 144)	NC score	0.303468 (rank : 110)
Query Neighborhood Hits	329	Target Neighborhood Hits	96	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	0.0736092 (rank : 145)	NC score	0.307978 (rank : 109)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

CRK_HUMAN
θ value	0.0961366 (rank : 146)	NC score	0.440371 (rank : 75)
Query Neighborhood Hits	329	Target Neighborhood Hits	308	Shared Neighborhood Hits	162
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0961366 (rank : 147)	NC score	0.446723 (rank : 70)
Query Neighborhood Hits	329	Target Neighborhood Hits	314	Shared Neighborhood Hits	164
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DGCR8_HUMAN
θ value	0.0961366 (rank : 148)	NC score	0.050996 (rank : 419)
Query Neighborhood Hits	329	Target Neighborhood Hits	72	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

HCK_MOUSE
θ value	0.0961366 (rank : 149)	NC score	0.146229 (rank : 180)
Query Neighborhood Hits	329	Target Neighborhood Hits	1029	Shared Neighborhood Hits	167
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ITK_HUMAN
θ value	0.0961366 (rank : 150)	NC score	0.107552 (rank : 222)
Query Neighborhood Hits	329	Target Neighborhood Hits	1016	Shared Neighborhood Hits	132
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MINT_MOUSE
θ value	0.0961366 (rank : 151)	NC score	0.061401 (rank : 369)
Query Neighborhood Hits	329	Target Neighborhood Hits	1514	Shared Neighborhood Hits	124
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NPHP1_MOUSE
θ value	0.0961366 (rank : 152)	NC score	0.430016 (rank : 77)
Query Neighborhood Hits	329	Target Neighborhood Hits	267	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

IASPP_MOUSE
θ value	0.125558 (rank : 153)	NC score	0.276713 (rank : 120)
Query Neighborhood Hits	329	Target Neighborhood Hits	1024	Shared Neighborhood Hits	209
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITK_MOUSE
θ value	0.125558 (rank : 154)	NC score	0.102294 (rank : 230)
Query Neighborhood Hits	329	Target Neighborhood Hits	985	Shared Neighborhood Hits	119
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

NCF1_MOUSE
θ value	0.125558 (rank : 155)	NC score	0.478884 (rank : 64)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	150
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ACINU_HUMAN
θ value	0.163984 (rank : 156)	NC score	0.056085 (rank : 386)
Query Neighborhood Hits	329	Target Neighborhood Hits	828	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

IASPP_HUMAN
θ value	0.163984 (rank : 157)	NC score	0.298874 (rank : 112)
Query Neighborhood Hits	329	Target Neighborhood Hits	688	Shared Neighborhood Hits	179
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RTN4_MOUSE
θ value	0.163984 (rank : 158)	NC score	0.063109 (rank : 361)
Query Neighborhood Hits	329	Target Neighborhood Hits	341	Shared Neighborhood Hits	46
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SRC_MOUSE
θ value	0.163984 (rank : 159)	NC score	0.142391 (rank : 187)
Query Neighborhood Hits	329	Target Neighborhood Hits	1033	Shared Neighborhood Hits	160
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

CUTL2_MOUSE
θ value	0.21417 (rank : 160)	NC score	0.028225 (rank : 475)
Query Neighborhood Hits	329	Target Neighborhood Hits	771	Shared Neighborhood Hits	41
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

ECM1_MOUSE
θ value	0.279714 (rank : 161)	NC score	0.051647 (rank : 413)
Query Neighborhood Hits	329	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

RUSC1_HUMAN
θ value	0.279714 (rank : 162)	NC score	0.331614 (rank : 105)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	140
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

DDEF2_HUMAN
θ value	0.365318 (rank : 163)	NC score	0.230983 (rank : 136)
Query Neighborhood Hits	329	Target Neighborhood Hits	599	Shared Neighborhood Hits	159
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.365318 (rank : 164)	NC score	0.232564 (rank : 135)
Query Neighborhood Hits	329	Target Neighborhood Hits	625	Shared Neighborhood Hits	151
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IZUM1_MOUSE
θ value	0.365318 (rank : 165)	NC score	0.037413 (rank : 460)
Query Neighborhood Hits	329	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9J7	Gene names	Izumo1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

NPHP1_HUMAN
θ value	0.365318 (rank : 166)	NC score	0.375650 (rank : 96)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	139
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

OGFR_MOUSE
θ value	0.365318 (rank : 167)	NC score	0.044720 (rank : 441)
Query Neighborhood Hits	329	Target Neighborhood Hits	584	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

SON_HUMAN
θ value	0.365318 (rank : 168)	NC score	0.066207 (rank : 343)
Query Neighborhood Hits	329	Target Neighborhood Hits	1568	Shared Neighborhood Hits	129
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

DOCK2_HUMAN
θ value	0.47712 (rank : 169)	NC score	0.085104 (rank : 281)
Query Neighborhood Hits	329	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

FMNL_MOUSE
θ value	0.47712 (rank : 170)	NC score	0.040594 (rank : 451)
Query Neighborhood Hits	329	Target Neighborhood Hits	428	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

TEC_HUMAN
θ value	0.47712 (rank : 171)	NC score	0.118640 (rank : 206)
Query Neighborhood Hits	329	Target Neighborhood Hits	1006	Shared Neighborhood Hits	135
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXLNB_HUMAN
θ value	0.47712 (rank : 172)	NC score	0.025461 (rank : 485)
Query Neighborhood Hits	329	Target Neighborhood Hits	912	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

AMPH_MOUSE
θ value	0.62314 (rank : 173)	NC score	0.200106 (rank : 143)
Query Neighborhood Hits	329	Target Neighborhood Hits	291	Shared Neighborhood Hits	89
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	0.62314 (rank : 174)	NC score	0.275703 (rank : 121)
Query Neighborhood Hits	329	Target Neighborhood Hits	175	Shared Neighborhood Hits	140
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG4_MOUSE
θ value	0.62314 (rank : 175)	NC score	0.292277 (rank : 114)
Query Neighborhood Hits	329	Target Neighborhood Hits	185	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BAT2_HUMAN
θ value	0.62314 (rank : 176)	NC score	0.080033 (rank : 294)
Query Neighborhood Hits	329	Target Neighborhood Hits	931	Shared Neighborhood Hits	99
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BTK_HUMAN
θ value	0.62314 (rank : 177)	NC score	0.144391 (rank : 185)
Query Neighborhood Hits	329	Target Neighborhood Hits	1026	Shared Neighborhood Hits	170
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DOK2_MOUSE
θ value	0.62314 (rank : 178)	NC score	0.033527 (rank : 467)
Query Neighborhood Hits	329	Target Neighborhood Hits	244	Shared Neighborhood Hits	40
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

SEPT9_HUMAN
θ value	0.62314 (rank : 179)	NC score	0.036723 (rank : 462)
Query Neighborhood Hits	329	Target Neighborhood Hits	706	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

WASL_HUMAN
θ value	0.62314 (rank : 180)	NC score	0.052136 (rank : 409)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

AMELX_HUMAN
θ value	0.813845 (rank : 181)	NC score	0.039926 (rank : 453)
Query Neighborhood Hits	329	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

BLNK_MOUSE
θ value	0.813845 (rank : 182)	NC score	0.093807 (rank : 251)
Query Neighborhood Hits	329	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ES8L2_HUMAN
θ value	0.813845 (rank : 183)	NC score	0.181078 (rank : 148)
Query Neighborhood Hits	329	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NCOA6_MOUSE
θ value	0.813845 (rank : 184)	NC score	0.060847 (rank : 372)
Query Neighborhood Hits	329	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SHLB2_HUMAN
θ value	0.813845 (rank : 185)	NC score	0.260234 (rank : 127)
Query Neighborhood Hits	329	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.813845 (rank : 186)	NC score	0.262272 (rank : 125)
Query Neighborhood Hits	329	Target Neighborhood Hits	88	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

TACC3_MOUSE
θ value	0.813845 (rank : 187)	NC score	0.029372 (rank : 474)
Query Neighborhood Hits	329	Target Neighborhood Hits	607	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

TEC_MOUSE
θ value	0.813845 (rank : 188)	NC score	0.113990 (rank : 212)
Query Neighborhood Hits	329	Target Neighborhood Hits	1006	Shared Neighborhood Hits	136
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ASPP2_HUMAN
θ value	1.06291 (rank : 189)	NC score	0.212902 (rank : 139)
Query Neighborhood Hits	329	Target Neighborhood Hits	1156	Shared Neighborhood Hits	180
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SPEG_HUMAN
θ value	1.06291 (rank : 190)	NC score	0.026889 (rank : 480)
Query Neighborhood Hits	329	Target Neighborhood Hits	1762	Shared Neighborhood Hits	107
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TROAP_HUMAN
θ value	1.06291 (rank : 191)	NC score	0.051090 (rank : 418)
Query Neighborhood Hits	329	Target Neighborhood Hits	258	Shared Neighborhood Hits	35
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

TXK_MOUSE
θ value	1.06291 (rank : 192)	NC score	0.117800 (rank : 207)
Query Neighborhood Hits	329	Target Neighborhood Hits	980	Shared Neighborhood Hits	130
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

ANM2_MOUSE
θ value	1.38821 (rank : 193)	NC score	0.256888 (rank : 129)
Query Neighborhood Hits	329	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CNTRB_MOUSE
θ value	1.38821 (rank : 194)	NC score	0.038351 (rank : 457)
Query Neighborhood Hits	329	Target Neighborhood Hits	1029	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

ENAM_HUMAN
θ value	1.38821 (rank : 195)	NC score	0.033006 (rank : 470)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

EP400_MOUSE
θ value	1.38821 (rank : 196)	NC score	0.026779 (rank : 482)
Query Neighborhood Hits	329	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

GGA1_HUMAN
θ value	1.38821 (rank : 197)	NC score	0.040503 (rank : 452)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

MLL3_HUMAN
θ value	1.38821 (rank : 198)	NC score	0.048388 (rank : 432)
Query Neighborhood Hits	329	Target Neighborhood Hits	1644	Shared Neighborhood Hits	119
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MYST3_HUMAN
θ value	1.38821 (rank : 199)	NC score	0.026951 (rank : 479)
Query Neighborhood Hits	329	Target Neighborhood Hits	772	Shared Neighborhood Hits	56
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

PKHA4_HUMAN
θ value	1.38821 (rank : 200)	NC score	0.027525 (rank : 477)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

S23IP_MOUSE
θ value	1.38821 (rank : 201)	NC score	0.041790 (rank : 447)
Query Neighborhood Hits	329	Target Neighborhood Hits	363	Shared Neighborhood Hits	60
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SV2B_MOUSE
θ value	1.38821 (rank : 202)	NC score	0.023576 (rank : 489)
Query Neighborhood Hits	329	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

TITIN_HUMAN
θ value	1.38821 (rank : 203)	NC score	0.023053 (rank : 492)
Query Neighborhood Hits	329	Target Neighborhood Hits	2923	Shared Neighborhood Hits	131
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

WASL_MOUSE
θ value	1.38821 (rank : 204)	NC score	0.053523 (rank : 404)
Query Neighborhood Hits	329	Target Neighborhood Hits	339	Shared Neighborhood Hits	43
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

CIC_MOUSE
θ value	1.81305 (rank : 205)	NC score	0.033071 (rank : 469)
Query Neighborhood Hits	329	Target Neighborhood Hits	742	Shared Neighborhood Hits	73
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DAB2_MOUSE
θ value	1.81305 (rank : 206)	NC score	0.024287 (rank : 487)
Query Neighborhood Hits	329	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

GOGA4_HUMAN
θ value	1.81305 (rank : 207)	NC score	0.033746 (rank : 466)
Query Neighborhood Hits	329	Target Neighborhood Hits	2034	Shared Neighborhood Hits	82
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

K0310_HUMAN
θ value	1.81305 (rank : 208)	NC score	0.046972 (rank : 433)
Query Neighborhood Hits	329	Target Neighborhood Hits	420	Shared Neighborhood Hits	49
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

LYN_MOUSE
θ value	1.81305 (rank : 209)	NC score	0.128205 (rank : 194)
Query Neighborhood Hits	329	Target Neighborhood Hits	1023	Shared Neighborhood Hits	154
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MAVS_HUMAN
θ value	1.81305 (rank : 210)	NC score	0.046915 (rank : 434)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

NACAM_MOUSE
θ value	1.81305 (rank : 211)	NC score	0.077595 (rank : 300)
Query Neighborhood Hits	329	Target Neighborhood Hits	1866	Shared Neighborhood Hits	146
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

OGFR_HUMAN
θ value	1.81305 (rank : 212)	NC score	0.062349 (rank : 367)
Query Neighborhood Hits	329	Target Neighborhood Hits	1582	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PTN12_MOUSE
θ value	1.81305 (rank : 213)	NC score	0.010500 (rank : 520)
Query Neighborhood Hits	329	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

RBM28_MOUSE
θ value	1.81305 (rank : 214)	NC score	0.011036 (rank : 519)
Query Neighborhood Hits	329	Target Neighborhood Hits	368	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CGC6, Q8BG25, Q8VEJ8, Q9CS22, Q9CSE6	Gene names	Rbm28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

TAU_HUMAN
θ value	1.81305 (rank : 215)	NC score	0.033756 (rank : 465)
Query Neighborhood Hits	329	Target Neighborhood Hits	448	Shared Neighborhood Hits	47
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ZN688_HUMAN
θ value	1.81305 (rank : 216)	NC score	-0.006383 (rank : 539)
Query Neighborhood Hits	329	Target Neighborhood Hits	873	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

ZO2_HUMAN
θ value	1.81305 (rank : 217)	NC score	0.017381 (rank : 501)
Query Neighborhood Hits	329	Target Neighborhood Hits	289	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

BTK_MOUSE
θ value	2.36792 (rank : 218)	NC score	0.136756 (rank : 190)
Query Neighborhood Hits	329	Target Neighborhood Hits	1017	Shared Neighborhood Hits	160
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CCNK_MOUSE
θ value	2.36792 (rank : 219)	NC score	0.049975 (rank : 430)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	46
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

FILA_HUMAN
θ value	2.36792 (rank : 220)	NC score	0.013867 (rank : 508)
Query Neighborhood Hits	329	Target Neighborhood Hits	685	Shared Neighborhood Hits	18
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

GP152_MOUSE
θ value	2.36792 (rank : 221)	NC score	0.011850 (rank : 513)
Query Neighborhood Hits	329	Target Neighborhood Hits	607	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

KLK1_MOUSE
θ value	2.36792 (rank : 222)	NC score	-0.001784 (rank : 537)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	2
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

LYN_HUMAN
θ value	2.36792 (rank : 223)	NC score	0.128789 (rank : 193)
Query Neighborhood Hits	329	Target Neighborhood Hits	1022	Shared Neighborhood Hits	153
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MDC1_MOUSE
θ value	2.36792 (rank : 224)	NC score	0.072231 (rank : 326)
Query Neighborhood Hits	329	Target Neighborhood Hits	998	Shared Neighborhood Hits	110
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NKTR_MOUSE
θ value	2.36792 (rank : 225)	NC score	0.012085 (rank : 512)
Query Neighborhood Hits	329	Target Neighborhood Hits	417	Shared Neighborhood Hits	26
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PCLO_MOUSE
θ value	2.36792 (rank : 226)	NC score	0.055519 (rank : 391)
Query Neighborhood Hits	329	Target Neighborhood Hits	2275	Shared Neighborhood Hits	145
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PEX13_HUMAN
θ value	2.36792 (rank : 227)	NC score	0.340097 (rank : 103)
Query Neighborhood Hits	329	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RTN4_HUMAN
θ value	2.36792 (rank : 228)	NC score	0.046266 (rank : 437)
Query Neighborhood Hits	329	Target Neighborhood Hits	357	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SN1L2_HUMAN
θ value	2.36792 (rank : 229)	NC score	0.027282 (rank : 478)
Query Neighborhood Hits	329	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

STS2_HUMAN
θ value	2.36792 (rank : 230)	NC score	0.183421 (rank : 147)
Query Neighborhood Hits	329	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

UB7I1_HUMAN
θ value	2.36792 (rank : 231)	NC score	0.017926 (rank : 498)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

ACINU_MOUSE
θ value	3.0926 (rank : 232)	NC score	0.051746 (rank : 412)
Query Neighborhood Hits	329	Target Neighborhood Hits	712	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AIM1_HUMAN
θ value	3.0926 (rank : 233)	NC score	0.027569 (rank : 476)
Query Neighborhood Hits	329	Target Neighborhood Hits	247	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

AMELY_HUMAN
θ value	3.0926 (rank : 234)	NC score	0.033315 (rank : 468)
Query Neighborhood Hits	329	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

BAT2_MOUSE
θ value	3.0926 (rank : 235)	NC score	0.066943 (rank : 340)
Query Neighborhood Hits	329	Target Neighborhood Hits	947	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DOCK4_MOUSE
θ value	3.0926 (rank : 236)	NC score	0.053790 (rank : 401)
Query Neighborhood Hits	329	Target Neighborhood Hits	210	Shared Neighborhood Hits	46
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

E2AK3_MOUSE
θ value	3.0926 (rank : 237)	NC score	0.024064 (rank : 488)
Query Neighborhood Hits	329	Target Neighborhood Hits	851	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

GGN_HUMAN
θ value	3.0926 (rank : 238)	NC score	0.046524 (rank : 436)
Query Neighborhood Hits	329	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

KSR1_HUMAN
θ value	3.0926 (rank : 239)	NC score	0.044066 (rank : 442)
Query Neighborhood Hits	329	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MAGB6_HUMAN
θ value	3.0926 (rank : 240)	NC score	0.009291 (rank : 526)
Query Neighborhood Hits	329	Target Neighborhood Hits	184	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MAP1A_HUMAN
θ value	3.0926 (rank : 241)	NC score	0.043182 (rank : 444)
Query Neighborhood Hits	329	Target Neighborhood Hits	1626	Shared Neighborhood Hits	101
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NCOA6_HUMAN
θ value	3.0926 (rank : 242)	NC score	0.067274 (rank : 337)
Query Neighborhood Hits	329	Target Neighborhood Hits	1202	Shared Neighborhood Hits	108
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PAG1_HUMAN
θ value	3.0926 (rank : 243)	NC score	0.023292 (rank : 491)
Query Neighborhood Hits	329	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

PEX13_MOUSE
θ value	3.0926 (rank : 244)	NC score	0.338399 (rank : 104)
Query Neighborhood Hits	329	Target Neighborhood Hits	126	Shared Neighborhood Hits	106
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PTN22_MOUSE
θ value	3.0926 (rank : 245)	NC score	0.020384 (rank : 496)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

PTN23_HUMAN
θ value	3.0926 (rank : 246)	NC score	0.026825 (rank : 481)
Query Neighborhood Hits	329	Target Neighborhood Hits	646	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

SYTL1_HUMAN
θ value	3.0926 (rank : 247)	NC score	0.012625 (rank : 510)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

WASIP_HUMAN
θ value	3.0926 (rank : 248)	NC score	0.063585 (rank : 357)
Query Neighborhood Hits	329	Target Neighborhood Hits	458	Shared Neighborhood Hits	59
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ANR11_HUMAN
θ value	4.03905 (rank : 249)	NC score	0.041507 (rank : 449)
Query Neighborhood Hits	329	Target Neighborhood Hits	1289	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

BPTF_HUMAN
θ value	4.03905 (rank : 250)	NC score	0.035309 (rank : 463)
Query Neighborhood Hits	329	Target Neighborhood Hits	786	Shared Neighborhood Hits	60
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CBP_HUMAN
θ value	4.03905 (rank : 251)	NC score	0.042678 (rank : 445)
Query Neighborhood Hits	329	Target Neighborhood Hits	941	Shared Neighborhood Hits	83
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CJ012_HUMAN
θ value	4.03905 (rank : 252)	NC score	0.040615 (rank : 450)
Query Neighborhood Hits	329	Target Neighborhood Hits	467	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

MLL4_HUMAN
θ value	4.03905 (rank : 253)	NC score	0.046731 (rank : 435)
Query Neighborhood Hits	329	Target Neighborhood Hits	722	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NPHP4_MOUSE
θ value	4.03905 (rank : 254)	NC score	0.015929 (rank : 504)
Query Neighborhood Hits	329	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

OXRP_HUMAN
θ value	4.03905 (rank : 255)	NC score	0.012350 (rank : 511)
Query Neighborhood Hits	329	Target Neighborhood Hits	544	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

PRR12_HUMAN
θ value	4.03905 (rank : 256)	NC score	0.064868 (rank : 352)
Query Neighborhood Hits	329	Target Neighborhood Hits	460	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

PTN22_HUMAN
θ value	4.03905 (rank : 257)	NC score	0.014088 (rank : 507)
Query Neighborhood Hits	329	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

PTN23_MOUSE
θ value	4.03905 (rank : 258)	NC score	0.026129 (rank : 483)
Query Neighborhood Hits	329	Target Neighborhood Hits	726	Shared Neighborhood Hits	68
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RIMB1_MOUSE
θ value	4.03905 (rank : 259)	NC score	0.151878 (rank : 174)
Query Neighborhood Hits	329	Target Neighborhood Hits	1376	Shared Neighborhood Hits	176
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SREC2_HUMAN
θ value	4.03905 (rank : 260)	NC score	0.010481 (rank : 521)
Query Neighborhood Hits	329	Target Neighborhood Hits	645	Shared Neighborhood Hits	34
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SRRM1_HUMAN
θ value	4.03905 (rank : 261)	NC score	0.049516 (rank : 431)
Query Neighborhood Hits	329	Target Neighborhood Hits	690	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TACC2_MOUSE
θ value	4.03905 (rank : 262)	NC score	0.036953 (rank : 461)
Query Neighborhood Hits	329	Target Neighborhood Hits	774	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TB182_HUMAN
θ value	4.03905 (rank : 263)	NC score	0.031124 (rank : 472)
Query Neighborhood Hits	329	Target Neighborhood Hits	414	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TRI37_HUMAN
θ value	4.03905 (rank : 264)	NC score	0.005494 (rank : 529)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

YLPM1_MOUSE
θ value	4.03905 (rank : 265)	NC score	0.059047 (rank : 375)
Query Neighborhood Hits	329	Target Neighborhood Hits	505	Shared Neighborhood Hits	57
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZN287_MOUSE
θ value	4.03905 (rank : 266)	NC score	-0.009202 (rank : 540)
Query Neighborhood Hits	329	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQB9	Gene names	Znf287, Skat2, Zfp287
Domain Architecture
Description	Zinc finger protein 287 (Zfp-287) (Zinc finger protein SKAT-2).

3BP1_MOUSE
θ value	5.27518 (rank : 267)	NC score	0.074110 (rank : 318)
Query Neighborhood Hits	329	Target Neighborhood Hits	238	Shared Neighborhood Hits	39
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CBP_MOUSE
θ value	5.27518 (rank : 268)	NC score	0.044748 (rank : 440)
Query Neighborhood Hits	329	Target Neighborhood Hits	1051	Shared Neighborhood Hits	96
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DOCK2_MOUSE
θ value	5.27518 (rank : 269)	NC score	0.074823 (rank : 312)
Query Neighborhood Hits	329	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

GSCR1_HUMAN
θ value	5.27518 (rank : 270)	NC score	0.061147 (rank : 370)
Query Neighborhood Hits	329	Target Neighborhood Hits	674	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MLL2_HUMAN
θ value	5.27518 (rank : 271)	NC score	0.054795 (rank : 396)
Query Neighborhood Hits	329	Target Neighborhood Hits	1788	Shared Neighborhood Hits	108
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NASP_HUMAN
θ value	5.27518 (rank : 272)	NC score	0.022816 (rank : 493)
Query Neighborhood Hits	329	Target Neighborhood Hits	709	Shared Neighborhood Hits	39
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

PCLO_HUMAN
θ value	5.27518 (rank : 273)	NC score	0.067079 (rank : 339)
Query Neighborhood Hits	329	Target Neighborhood Hits	2046	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PRDM2_HUMAN
θ value	5.27518 (rank : 274)	NC score	0.011540 (rank : 516)
Query Neighborhood Hits	329	Target Neighborhood Hits	1135	Shared Neighborhood Hits	56
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PRR8_HUMAN
θ value	5.27518 (rank : 275)	NC score	0.037779 (rank : 459)
Query Neighborhood Hits	329	Target Neighborhood Hits	217	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

SH2D3_HUMAN
θ value	5.27518 (rank : 276)	NC score	0.074352 (rank : 316)
Query Neighborhood Hits	329	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SN1L2_MOUSE
θ value	5.27518 (rank : 277)	NC score	0.026114 (rank : 484)
Query Neighborhood Hits	329	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ZN541_HUMAN
θ value	5.27518 (rank : 278)	NC score	0.014742 (rank : 506)
Query Neighborhood Hits	329	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

3BP1_HUMAN
θ value	6.88961 (rank : 279)	NC score	0.089170 (rank : 267)
Query Neighborhood Hits	329	Target Neighborhood Hits	376	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ANK3_HUMAN
θ value	6.88961 (rank : 280)	NC score	0.017285 (rank : 502)
Query Neighborhood Hits	329	Target Neighborhood Hits	853	Shared Neighborhood Hits	54
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ATN1_HUMAN
θ value	6.88961 (rank : 281)	NC score	0.043622 (rank : 443)
Query Neighborhood Hits	329	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BPL1_HUMAN
θ value	6.88961 (rank : 282)	NC score	0.017390 (rank : 500)
Query Neighborhood Hits	329	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P50747, Q99451	Gene names	HLCS
Domain Architecture
Description	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin-- [acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)].

CGRE1_HUMAN
θ value	6.88961 (rank : 283)	NC score	0.017525 (rank : 499)
Query Neighborhood Hits	329	Target Neighborhood Hits	354	Shared Neighborhood Hits	24
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CLCN1_MOUSE
θ value	6.88961 (rank : 284)	NC score	0.005468 (rank : 530)
Query Neighborhood Hits	329	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CTNB1_HUMAN
θ value	6.88961 (rank : 285)	NC score	0.009905 (rank : 523)
Query Neighborhood Hits	329	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_MOUSE
θ value	6.88961 (rank : 286)	NC score	0.009912 (rank : 522)
Query Neighborhood Hits	329	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

DNJC8_HUMAN
θ value	6.88961 (rank : 287)	NC score	0.030376 (rank : 473)
Query Neighborhood Hits	329	Target Neighborhood Hits	380	Shared Neighborhood Hits	20
SwissProt Accessions	O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067	Gene names	DNAJC8, SPF31
Domain Architecture
Description	DnaJ homolog subfamily C member 8 (Splicing protein spf31).

DNJC8_MOUSE
θ value	6.88961 (rank : 288)	NC score	0.032042 (rank : 471)
Query Neighborhood Hits	329	Target Neighborhood Hits	392	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

FUS_HUMAN
θ value	6.88961 (rank : 289)	NC score	0.011365 (rank : 518)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P35637	Gene names	FUS, TLS
Domain Architecture
Description	RNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated in liposarcoma protein) (POMp75) (75 kDa DNA-pairing protein).

FUS_MOUSE
θ value	6.88961 (rank : 290)	NC score	0.011450 (rank : 517)
Query Neighborhood Hits	329	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	P56959	Gene names	Fus
Domain Architecture
Description	RNA-binding protein FUS (Pigpen protein).

JPH3_HUMAN
θ value	6.88961 (rank : 291)	NC score	0.005230 (rank : 532)
Query Neighborhood Hits	329	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

KI21A_MOUSE
θ value	6.88961 (rank : 292)	NC score	0.008064 (rank : 528)
Query Neighborhood Hits	329	Target Neighborhood Hits	1317	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

KNG1_HUMAN
θ value	6.88961 (rank : 293)	NC score	0.009846 (rank : 525)
Query Neighborhood Hits	329	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P01042, P01043	Gene names	KNG1, BDK, KNG
Domain Architecture
Description	Kininogen-1 precursor (Alpha-2-thiol proteinase inhibitor) [Contains: Kininogen-1 heavy chain; Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth- promoting factor].

MAGE1_HUMAN
θ value	6.88961 (rank : 294)	NC score	0.050799 (rank : 423)
Query Neighborhood Hits	329	Target Neighborhood Hits	1389	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MOR2B_MOUSE
θ value	6.88961 (rank : 295)	NC score	0.008103 (rank : 527)
Query Neighborhood Hits	329	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

MS3L1_HUMAN
θ value	6.88961 (rank : 296)	NC score	0.009884 (rank : 524)
Query Neighborhood Hits	329	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N5Y2, Q9UG70, Q9Y5Z8	Gene names	MSL3L1
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

NBN_HUMAN
θ value	6.88961 (rank : 297)	NC score	0.015639 (rank : 505)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	20
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

NEIL1_HUMAN
θ value	6.88961 (rank : 298)	NC score	0.011824 (rank : 514)
Query Neighborhood Hits	329	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q96FI4, Q6ZRA7, Q86XW7, Q9H6C3	Gene names	NEIL1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1).

NOS3_HUMAN
θ value	6.88961 (rank : 299)	NC score	0.005461 (rank : 531)
Query Neighborhood Hits	329	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

RIMB1_HUMAN
θ value	6.88961 (rank : 300)	NC score	0.157333 (rank : 170)
Query Neighborhood Hits	329	Target Neighborhood Hits	1479	Shared Neighborhood Hits	182
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ROA0_HUMAN
θ value	6.88961 (rank : 301)	NC score	0.002137 (rank : 535)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	4
SwissProt Accessions	Q13151	Gene names	HNRPA0
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0).

RT18B_HUMAN
θ value	6.88961 (rank : 302)	NC score	0.011708 (rank : 515)
Query Neighborhood Hits	329	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y676, Q9BS27	Gene names	MRPS18B
Domain Architecture
Description	28S ribosomal protein S18b, mitochondrial precursor (MRP-S18-b) (Mrps18b) (MRP-S18-2).

SNIP_HUMAN
θ value	6.88961 (rank : 303)	NC score	0.025333 (rank : 486)
Query Neighborhood Hits	329	Target Neighborhood Hits	313	Shared Neighborhood Hits	27
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

TACC2_HUMAN
θ value	6.88961 (rank : 304)	NC score	0.041719 (rank : 448)
Query Neighborhood Hits	329	Target Neighborhood Hits	856	Shared Neighborhood Hits	74
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

ACK1_HUMAN
θ value	8.99809 (rank : 305)	NC score	0.066290 (rank : 341)
Query Neighborhood Hits	329	Target Neighborhood Hits	1140	Shared Neighborhood Hits	118
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	8.99809 (rank : 306)	NC score	0.066195 (rank : 344)
Query Neighborhood Hits	329	Target Neighborhood Hits	1080	Shared Neighborhood Hits	121
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

BAT3_HUMAN
θ value	8.99809 (rank : 307)	NC score	0.034862 (rank : 464)
Query Neighborhood Hits	329	Target Neighborhood Hits	490	Shared Neighborhood Hits	54
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BRD4_HUMAN
θ value	8.99809 (rank : 308)	NC score	0.038415 (rank : 456)
Query Neighborhood Hits	329	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BRD4_MOUSE
θ value	8.99809 (rank : 309)	NC score	0.039216 (rank : 454)
Query Neighborhood Hits	329	Target Neighborhood Hits	845	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

DSG2_MOUSE
θ value	8.99809 (rank : 310)	NC score	-0.002113 (rank : 538)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	O55111, Q8K069, Q8R517	Gene names	Dsg2
Domain Architecture
Description	Desmoglein-2 precursor.

ES8L2_MOUSE
θ value	8.99809 (rank : 311)	NC score	0.170280 (rank : 156)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	116
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FUT8_HUMAN
θ value	8.99809 (rank : 312)	NC score	0.087884 (rank : 273)
Query Neighborhood Hits	329	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

HXA3_HUMAN
θ value	8.99809 (rank : 313)	NC score	0.004540 (rank : 533)
Query Neighborhood Hits	329	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

KCNH3_MOUSE
θ value	8.99809 (rank : 314)	NC score	0.001873 (rank : 536)
Query Neighborhood Hits	329	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

LARP4_MOUSE
θ value	8.99809 (rank : 315)	NC score	0.022396 (rank : 494)
Query Neighborhood Hits	329	Target Neighborhood Hits	260	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

LCK_HUMAN
θ value	8.99809 (rank : 316)	NC score	0.109037 (rank : 218)
Query Neighborhood Hits	329	Target Neighborhood Hits	987	Shared Neighborhood Hits	112
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	8.99809 (rank : 317)	NC score	0.108101 (rank : 220)
Query Neighborhood Hits	329	Target Neighborhood Hits	981	Shared Neighborhood Hits	111
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MAGC1_HUMAN
θ value	8.99809 (rank : 318)	NC score	0.016352 (rank : 503)
Query Neighborhood Hits	329	Target Neighborhood Hits	431	Shared Neighborhood Hits	49
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

PCD15_HUMAN
θ value	8.99809 (rank : 319)	NC score	0.002177 (rank : 534)
Query Neighborhood Hits	329	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

PCQAP_MOUSE
θ value	8.99809 (rank : 320)	NC score	0.042394 (rank : 446)
Query Neighborhood Hits	329	Target Neighborhood Hits	506	Shared Neighborhood Hits	44
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PKN1_HUMAN
θ value	8.99809 (rank : 321)	NC score	0.021195 (rank : 495)
Query Neighborhood Hits	329	Target Neighborhood Hits	886	Shared Neighborhood Hits	42
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PRB4S_HUMAN
θ value	8.99809 (rank : 322)	NC score	0.038645 (rank : 455)
Query Neighborhood Hits	329	Target Neighborhood Hits	330	Shared Neighborhood Hits	41
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

RPGF1_HUMAN
θ value	8.99809 (rank : 323)	NC score	0.023418 (rank : 490)
Query Neighborhood Hits	329	Target Neighborhood Hits	262	Shared Neighborhood Hits	45
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS1_HUMAN
θ value	8.99809 (rank : 324)	NC score	0.062637 (rank : 366)
Query Neighborhood Hits	329	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	8.99809 (rank : 325)	NC score	0.063012 (rank : 362)
Query Neighborhood Hits	329	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SRRM2_HUMAN
θ value	8.99809 (rank : 326)	NC score	0.050129 (rank : 429)
Query Neighborhood Hits	329	Target Neighborhood Hits	1296	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STS1_MOUSE
θ value	8.99809 (rank : 327)	NC score	0.149647 (rank : 177)
Query Neighborhood Hits	329	Target Neighborhood Hits	104	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TNNT1_MOUSE
θ value	8.99809 (rank : 328)	NC score	0.013649 (rank : 509)
Query Neighborhood Hits	329	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

ZO2_MOUSE
θ value	8.99809 (rank : 329)	NC score	0.018337 (rank : 497)
Query Neighborhood Hits	329	Target Neighborhood Hits	296	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

AATK_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.050394 (rank : 426)
Query Neighborhood Hits	329	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABL1_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.105427 (rank : 228)
Query Neighborhood Hits	329	Target Neighborhood Hits	1220	Shared Neighborhood Hits	150
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.106484 (rank : 224)
Query Neighborhood Hits	329	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.100379 (rank : 235)
Query Neighborhood Hits	329	Target Neighborhood Hits	1045	Shared Neighborhood Hits	125
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABR_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.087547 (rank : 276)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

APS_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.097179 (rank : 241)
Query Neighborhood Hits	329	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.073360 (rank : 323)
Query Neighborhood Hits	329	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.090765 (rank : 261)
Query Neighborhood Hits	329	Target Neighborhood Hits	176	Shared Neighborhood Hits	26
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.077491 (rank : 303)
Query Neighborhood Hits	329	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.075032 (rank : 310)
Query Neighborhood Hits	329	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.073610 (rank : 322)
Query Neighborhood Hits	329	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.123862 (rank : 200)
Query Neighborhood Hits	329	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.123668 (rank : 201)
Query Neighborhood Hits	329	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.180063 (rank : 149)
Query Neighborhood Hits	329	Target Neighborhood Hits	172	Shared Neighborhood Hits	84
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.113218 (rank : 213)
Query Neighborhood Hits	329	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.119809 (rank : 205)
Query Neighborhood Hits	329	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.101073 (rank : 233)
Query Neighborhood Hits	329	Target Neighborhood Hits	187	Shared Neighborhood Hits	24
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.107611 (rank : 221)
Query Neighborhood Hits	329	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.090913 (rank : 259)
Query Neighborhood Hits	329	Target Neighborhood Hits	375	Shared Neighborhood Hits	32
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.090838 (rank : 260)
Query Neighborhood Hits	329	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.089664 (rank : 264)
Query Neighborhood Hits	329	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.082240 (rank : 287)
Query Neighborhood Hits	329	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.121353 (rank : 204)
Query Neighborhood Hits	329	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.138547 (rank : 189)
Query Neighborhood Hits	329	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BAIP2_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.096820 (rank : 242)
Query Neighborhood Hits	329	Target Neighborhood Hits	192	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.099182 (rank : 237)
Query Neighborhood Hits	329	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR3_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.066237 (rank : 342)
Query Neighborhood Hits	329	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.065986 (rank : 346)
Query Neighborhood Hits	329	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.097837 (rank : 240)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.111750 (rank : 215)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.089173 (rank : 266)
Query Neighborhood Hits	329	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.149995 (rank : 176)
Query Neighborhood Hits	329	Target Neighborhood Hits	335	Shared Neighborhood Hits	87
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.148100 (rank : 178)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	92
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.117799 (rank : 208)
Query Neighborhood Hits	329	Target Neighborhood Hits	994	Shared Neighborhood Hits	136
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.113215 (rank : 214)
Query Neighborhood Hits	329	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.074827 (rank : 311)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BMX_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.064991 (rank : 351)
Query Neighborhood Hits	329	Target Neighborhood Hits	942	Shared Neighborhood Hits	59
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.065231 (rank : 349)
Query Neighborhood Hits	329	Target Neighborhood Hits	912	Shared Neighborhood Hits	59
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BSN_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.051275 (rank : 416)
Query Neighborhood Hits	329	Target Neighborhood Hits	2057	Shared Neighborhood Hits	132
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CHIN_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.095544 (rank : 247)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.096480 (rank : 244)
Query Neighborhood Hits	329	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.093649 (rank : 252)
Query Neighborhood Hits	329	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.066010 (rank : 345)
Query Neighborhood Hits	329	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.156047 (rank : 172)
Query Neighborhood Hits	329	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ078_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.050535 (rank : 424)
Query Neighborhood Hits	329	Target Neighborhood Hits	559	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CS016_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.054641 (rank : 397)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DAPP1_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.116973 (rank : 211)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.117699 (rank : 209)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DREB_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.084921 (rank : 283)
Query Neighborhood Hits	329	Target Neighborhood Hits	450	Shared Neighborhood Hits	37
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.093451 (rank : 254)
Query Neighborhood Hits	329	Target Neighborhood Hits	446	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ECT2_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.094412 (rank : 250)
Query Neighborhood Hits	329	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.098077 (rank : 239)
Query Neighborhood Hits	329	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.084351 (rank : 284)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	86
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.081084 (rank : 291)
Query Neighborhood Hits	329	Target Neighborhood Hits	221	Shared Neighborhood Hits	81
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ENAH_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.051566 (rank : 415)
Query Neighborhood Hits	329	Target Neighborhood Hits	919	Shared Neighborhood Hits	73
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EPS8_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.156450 (rank : 171)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	101
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.166546 (rank : 159)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	115
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.152336 (rank : 173)
Query Neighborhood Hits	329	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.144568 (rank : 184)
Query Neighborhood Hits	329	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.199380 (rank : 144)
Query Neighborhood Hits	329	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 390)	NC score	0.217723 (rank : 138)
Query Neighborhood Hits	329	Target Neighborhood Hits	168	Shared Neighborhood Hits	134
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FARP1_HUMAN
θ value	θ > 10 (rank : 391)	NC score	0.058899 (rank : 377)
Query Neighborhood Hits	329	Target Neighborhood Hits	241	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.060305 (rank : 373)
Query Neighborhood Hits	329	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 393)	NC score	0.065046 (rank : 350)
Query Neighborhood Hits	329	Target Neighborhood Hits	209	Shared Neighborhood Hits	29
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.069520 (rank : 335)
Query Neighborhood Hits	329	Target Neighborhood Hits	1278	Shared Neighborhood Hits	86
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FES_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.053176 (rank : 406)
Query Neighborhood Hits	329	Target Neighborhood Hits	978	Shared Neighborhood Hits	59
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGD1_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.073893 (rank : 319)
Query Neighborhood Hits	329	Target Neighborhood Hits	367	Shared Neighborhood Hits	52
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.069798 (rank : 334)
Query Neighborhood Hits	329	Target Neighborhood Hits	387	Shared Neighborhood Hits	46
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.074179 (rank : 317)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 399)	NC score	0.070048 (rank : 333)
Query Neighborhood Hits	329	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.075152 (rank : 309)
Query Neighborhood Hits	329	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 401)	NC score	0.080904 (rank : 292)
Query Neighborhood Hits	329	Target Neighborhood Hits	257	Shared Neighborhood Hits	29
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.077685 (rank : 299)
Query Neighborhood Hits	329	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.077568 (rank : 302)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.055730 (rank : 388)
Query Neighborhood Hits	329	Target Neighborhood Hits	237	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.063688 (rank : 355)
Query Neighborhood Hits	329	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FUT8_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.071801 (rank : 328)
Query Neighborhood Hits	329	Target Neighborhood Hits	115	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GNRP_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.071795 (rank : 329)
Query Neighborhood Hits	329	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.081440 (rank : 290)
Query Neighborhood Hits	329	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.071320 (rank : 330)
Query Neighborhood Hits	329	Target Neighborhood Hits	147	Shared Neighborhood Hits	42
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.072849 (rank : 325)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	44
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.092695 (rank : 255)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.094595 (rank : 249)
Query Neighborhood Hits	329	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.074495 (rank : 315)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.083998 (rank : 285)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.086235 (rank : 278)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HGS_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.052411 (rank : 408)
Query Neighborhood Hits	329	Target Neighborhood Hits	589	Shared Neighborhood Hits	54
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.088427 (rank : 269)
Query Neighborhood Hits	329	Target Neighborhood Hits	159	Shared Neighborhood Hits	41
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.061520 (rank : 368)
Query Neighborhood Hits	329	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.055462 (rank : 392)
Query Neighborhood Hits	329	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.055265 (rank : 393)
Query Neighborhood Hits	329	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.055737 (rank : 387)
Query Neighborhood Hits	329	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

JIP1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.074820 (rank : 313)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.071819 (rank : 327)
Query Neighborhood Hits	329	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.087677 (rank : 275)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	71
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 425)	NC score	0.081914 (rank : 288)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KSYK_HUMAN
θ value	θ > 10 (rank : 426)	NC score	0.063324 (rank : 359)
Query Neighborhood Hits	329	Target Neighborhood Hits	901	Shared Neighborhood Hits	62
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 427)	NC score	0.064658 (rank : 353)
Query Neighborhood Hits	329	Target Neighborhood Hits	944	Shared Neighborhood Hits	66
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LBC_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.079740 (rank : 295)
Query Neighborhood Hits	329	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCP2_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.091479 (rank : 258)
Query Neighborhood Hits	329	Target Neighborhood Hits	531	Shared Neighborhood Hits	98
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.085342 (rank : 280)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.088134 (rank : 272)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.085043 (rank : 282)
Query Neighborhood Hits	329	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MATK_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.076746 (rank : 307)
Query Neighborhood Hits	329	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.077586 (rank : 301)
Query Neighborhood Hits	329	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 435)	NC score	0.127833 (rank : 196)
Query Neighborhood Hits	329	Target Neighborhood Hits	255	Shared Neighborhood Hits	47
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.105207 (rank : 229)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	27
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MNT_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.050899 (rank : 422)
Query Neighborhood Hits	329	Target Neighborhood Hits	432	Shared Neighborhood Hits	50
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MPP5_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.056470 (rank : 383)
Query Neighborhood Hits	329	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.055611 (rank : 390)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.070405 (rank : 331)
Query Neighborhood Hits	329	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.067315 (rank : 336)
Query Neighborhood Hits	329	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MUC7_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.053067 (rank : 407)
Query Neighborhood Hits	329	Target Neighborhood Hits	538	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MYO9B_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.053642 (rank : 403)
Query Neighborhood Hits	329	Target Neighborhood Hits	641	Shared Neighborhood Hits	70
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NGEF_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.161707 (rank : 169)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	78
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.163573 (rank : 164)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NRAP_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.063003 (rank : 363)
Query Neighborhood Hits	329	Target Neighborhood Hits	159	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.063219 (rank : 360)
Query Neighborhood Hits	329	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

OPHN1_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.058781 (rank : 378)
Query Neighborhood Hits	329	Target Neighborhood Hits	161	Shared Neighborhood Hits	25
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.055225 (rank : 394)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P55G_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.107386 (rank : 223)
Query Neighborhood Hits	329	Target Neighborhood Hits	451	Shared Neighborhood Hits	56
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.106174 (rank : 226)
Query Neighborhood Hits	329	Target Neighborhood Hits	401	Shared Neighborhood Hits	55
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.162662 (rank : 166)
Query Neighborhood Hits	329	Target Neighborhood Hits	479	Shared Neighborhood Hits	108
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.171940 (rank : 152)
Query Neighborhood Hits	329	Target Neighborhood Hits	435	Shared Neighborhood Hits	112
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.127398 (rank : 197)
Query Neighborhood Hits	329	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHG1_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.134396 (rank : 191)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.062688 (rank : 365)
Query Neighborhood Hits	329	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PPIP2_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.098624 (rank : 238)
Query Neighborhood Hits	329	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.087378 (rank : 277)
Query Neighborhood Hits	329	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PREX1_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.128091 (rank : 195)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PRP2_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.057484 (rank : 381)
Query Neighborhood Hits	329	Target Neighborhood Hits	347	Shared Neighborhood Hits	41
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRRT3_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.054483 (rank : 398)
Query Neighborhood Hits	329	Target Neighborhood Hits	998	Shared Neighborhood Hits	103
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PTK6_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.108403 (rank : 219)
Query Neighborhood Hits	329	Target Neighborhood Hits	1020	Shared Neighborhood Hits	153
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.110060 (rank : 217)
Query Neighborhood Hits	329	Target Neighborhood Hits	1026	Shared Neighborhood Hits	150
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.077419 (rank : 305)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.077437 (rank : 304)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.065923 (rank : 347)
Query Neighborhood Hits	329	Target Neighborhood Hits	234	Shared Neighborhood Hits	53
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

PTN6_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.067268 (rank : 338)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.131022 (rank : 192)
Query Neighborhood Hits	329	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS2_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.057782 (rank : 380)
Query Neighborhood Hits	329	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.056466 (rank : 384)
Query Neighborhood Hits	329	Target Neighborhood Hits	102	Shared Neighborhood Hits	16
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.083074 (rank : 286)
Query Neighborhood Hits	329	Target Neighborhood Hits	641	Shared Neighborhood Hits	48
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RGS3_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.053762 (rank : 402)
Query Neighborhood Hits	329	Target Neighborhood Hits	1375	Shared Neighborhood Hits	108
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RHG09_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.077413 (rank : 306)
Query Neighborhood Hits	329	Target Neighborhood Hits	186	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.073714 (rank : 321)
Query Neighborhood Hits	329	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.076599 (rank : 308)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	48
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG25_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.055714 (rank : 389)
Query Neighborhood Hits	329	Target Neighborhood Hits	492	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RIMB2_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.262106 (rank : 126)
Query Neighborhood Hits	329	Target Neighborhood Hits	263	Shared Neighborhood Hits	113
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.256213 (rank : 130)
Query Neighborhood Hits	329	Target Neighborhood Hits	246	Shared Neighborhood Hits	106
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC2_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.111299 (rank : 216)
Query Neighborhood Hits	329	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.106469 (rank : 225)
Query Neighborhood Hits	329	Target Neighborhood Hits	305	Shared Neighborhood Hits	86
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SAMN1_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.065537 (rank : 348)
Query Neighborhood Hits	329	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.060966 (rank : 371)
Query Neighborhood Hits	329	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.079014 (rank : 298)
Query Neighborhood Hits	329	Target Neighborhood Hits	292	Shared Neighborhood Hits	72
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.070224 (rank : 332)
Query Neighborhood Hits	329	Target Neighborhood Hits	263	Shared Neighborhood Hits	65
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.081608 (rank : 289)
Query Neighborhood Hits	329	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.080710 (rank : 293)
Query Neighborhood Hits	329	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.099850 (rank : 236)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.101753 (rank : 231)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.073745 (rank : 320)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.079642 (rank : 296)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.060014 (rank : 374)
Query Neighborhood Hits	329	Target Neighborhood Hits	149	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.074637 (rank : 314)
Query Neighborhood Hits	329	Target Neighborhood Hits	455	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.055106 (rank : 395)
Query Neighborhood Hits	329	Target Neighborhood Hits	326	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.073148 (rank : 324)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHB_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.093543 (rank : 253)
Query Neighborhood Hits	329	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 496)	NC score	0.095866 (rank : 246)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.092353 (rank : 256)
Query Neighborhood Hits	329	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 498)	NC score	0.091514 (rank : 257)
Query Neighborhood Hits	329	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 499)	NC score	0.089429 (rank : 265)
Query Neighborhood Hits	329	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.088143 (rank : 271)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.090736 (rank : 262)
Query Neighborhood Hits	329	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 502)	NC score	0.096653 (rank : 243)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 503)	NC score	0.090136 (rank : 263)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 504)	NC score	0.087760 (rank : 274)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 505)	NC score	0.096334 (rank : 245)
Query Neighborhood Hits	329	Target Neighborhood Hits	164	Shared Neighborhood Hits	49
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 506)	NC score	0.100639 (rank : 234)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.147399 (rank : 179)
Query Neighborhood Hits	329	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.145695 (rank : 181)
Query Neighborhood Hits	329	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.161874 (rank : 168)
Query Neighborhood Hits	329	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 510)	NC score	0.162016 (rank : 167)
Query Neighborhood Hits	329	Target Neighborhood Hits	136	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.101410 (rank : 232)
Query Neighborhood Hits	329	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.117037 (rank : 210)
Query Neighborhood Hits	329	Target Neighborhood Hits	108	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX9_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.202828 (rank : 142)
Query Neighborhood Hits	329	Target Neighborhood Hits	148	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.179300 (rank : 150)
Query Neighborhood Hits	329	Target Neighborhood Hits	141	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOCS2_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.051142 (rank : 417)
Query Neighborhood Hits	329	Target Neighborhood Hits	94	Shared Neighborhood Hits	31
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS6_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.054001 (rank : 399)
Query Neighborhood Hits	329	Target Neighborhood Hits	126	Shared Neighborhood Hits	33
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.053899 (rank : 400)
Query Neighborhood Hits	329	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	θ > 10 (rank : 518)	NC score	0.063566 (rank : 358)
Query Neighborhood Hits	329	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SON_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.056504 (rank : 382)
Query Neighborhood Hits	329	Target Neighborhood Hits	957	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SPN90_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.185338 (rank : 146)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.163109 (rank : 165)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.079622 (rank : 297)
Query Neighborhood Hits	329	Target Neighborhood Hits	946	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.088776 (rank : 268)
Query Neighborhood Hits	329	Target Neighborhood Hits	964	Shared Neighborhood Hits	105
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SRRM1_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.051628 (rank : 414)
Query Neighborhood Hits	329	Target Neighborhood Hits	966	Shared Neighborhood Hits	93
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STS1_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.145572 (rank : 182)
Query Neighborhood Hits	329	Target Neighborhood Hits	106	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

TAF4_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.050961 (rank : 420)
Query Neighborhood Hits	329	Target Neighborhood Hits	687	Shared Neighborhood Hits	64
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARSH_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.056431 (rank : 385)
Query Neighborhood Hits	329	Target Neighborhood Hits	768	Shared Neighborhood Hits	95
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TEX14_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.059010 (rank : 376)
Query Neighborhood Hits	329	Target Neighborhood Hits	1103	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.057953 (rank : 379)
Query Neighborhood Hits	329	Target Neighborhood Hits	1333	Shared Neighborhood Hits	68
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIAM1_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.124506 (rank : 198)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.124446 (rank : 199)
Query Neighborhood Hits	329	Target Neighborhood Hits	205	Shared Neighborhood Hits	28
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TNK1_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.050313 (rank : 427)
Query Neighborhood Hits	329	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.050471 (rank : 425)
Query Neighborhood Hits	329	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TRIO_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.062971 (rank : 364)
Query Neighborhood Hits	329	Target Neighborhood Hits	1580	Shared Neighborhood Hits	109
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXK_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.105706 (rank : 227)
Query Neighborhood Hits	329	Target Neighborhood Hits	971	Shared Neighborhood Hits	121
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXND2_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.052040 (rank : 411)
Query Neighborhood Hits	329	Target Neighborhood Hits	793	Shared Neighborhood Hits	83
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

WASIP_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.053267 (rank : 405)
Query Neighborhood Hits	329	Target Neighborhood Hits	392	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

YLPM1_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.050222 (rank : 428)
Query Neighborhood Hits	329	Target Neighborhood Hits	670	Shared Neighborhood Hits	63
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZAP70_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.063628 (rank : 356)
Query Neighborhood Hits	329	Target Neighborhood Hits	893	Shared Neighborhood Hits	62
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.064367 (rank : 354)
Query Neighborhood Hits	329	Target Neighborhood Hits	905	Shared Neighborhood Hits	62
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

Hits sorted by NC score

HCLS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	329	Target Neighborhood Hits	329	Shared Neighborhood Hits	329
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.965799 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	329	Target Neighborhood Hits	358	Shared Neighborhood Hits	221
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRC8_MOUSE
NC score	0.941511 (rank : 3)	θ value	6.24247e-110 (rank : 3)
Query Neighborhood Hits	329	Target Neighborhood Hits	292	Shared Neighborhood Hits	181
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
NC score	0.937638 (rank : 4)	θ value	9.056e-93 (rank : 4)
Query Neighborhood Hits	329	Target Neighborhood Hits	269	Shared Neighborhood Hits	178
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

DBNL_HUMAN
NC score	0.699813 (rank : 5)	θ value	5.25075e-16 (rank : 6)
Query Neighborhood Hits	329	Target Neighborhood Hits	244	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.691198 (rank : 6)	θ value	3.07829e-16 (rank : 5)
Query Neighborhood Hits	329	Target Neighborhood Hits	306	Shared Neighborhood Hits	157
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SH3K1_MOUSE
NC score	0.657440 (rank : 7)	θ value	2.36244e-08 (rank : 11)
Query Neighborhood Hits	329	Target Neighborhood Hits	332	Shared Neighborhood Hits	176
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3K1_HUMAN
NC score	0.656587 (rank : 8)	θ value	1.80886e-08 (rank : 10)
Query Neighborhood Hits	329	Target Neighborhood Hits	341	Shared Neighborhood Hits	175
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_MOUSE
NC score	0.649646 (rank : 9)	θ value	3.41135e-07 (rank : 19)
Query Neighborhood Hits	329	Target Neighborhood Hits	336	Shared Neighborhood Hits	186
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2AP_HUMAN
NC score	0.635209 (rank : 10)	θ value	6.43352e-06 (rank : 39)
Query Neighborhood Hits	329	Target Neighborhood Hits	315	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

ABI2_HUMAN
NC score	0.624753 (rank : 11)	θ value	1.69304e-06 (rank : 31)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	188
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.624261 (rank : 12)	θ value	1.69304e-06 (rank : 32)
Query Neighborhood Hits	329	Target Neighborhood Hits	266	Shared Neighborhood Hits	173
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF2_HUMAN
NC score	0.623903 (rank : 13)	θ value	5.44631e-05 (rank : 59)
Query Neighborhood Hits	329	Target Neighborhood Hits	229	Shared Neighborhood Hits	154
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G2_HUMAN
NC score	0.618187 (rank : 14)	θ value	1.06045e-08 (rank : 9)
Query Neighborhood Hits	329	Target Neighborhood Hits	324	Shared Neighborhood Hits	169
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
NC score	0.617212 (rank : 15)	θ value	1.53129e-07 (rank : 17)
Query Neighborhood Hits	329	Target Neighborhood Hits	236	Shared Neighborhood Hits	164
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VINEX_HUMAN
NC score	0.611446 (rank : 16)	θ value	9.29e-05 (rank : 70)
Query Neighborhood Hits	329	Target Neighborhood Hits	270	Shared Neighborhood Hits	178
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI1_MOUSE
NC score	0.610452 (rank : 17)	θ value	1.69304e-06 (rank : 30)
Query Neighborhood Hits	329	Target Neighborhood Hits	246	Shared Neighborhood Hits	166
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G2_MOUSE
NC score	0.609090 (rank : 18)	θ value	8.97725e-08 (rank : 15)
Query Neighborhood Hits	329	Target Neighborhood Hits	319	Shared Neighborhood Hits	168
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

VINEX_MOUSE
NC score	0.608898 (rank : 19)	θ value	4.1701e-05 (rank : 58)
Query Neighborhood Hits	329	Target Neighborhood Hits	286	Shared Neighborhood Hits	180
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SH3G3_HUMAN
NC score	0.607428 (rank : 20)	θ value	9.92553e-07 (rank : 25)
Query Neighborhood Hits	329	Target Neighborhood Hits	222	Shared Neighborhood Hits	161
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ABI1_HUMAN
NC score	0.593366 (rank : 21)	θ value	2.21117e-06 (rank : 33)
Query Neighborhood Hits	329	Target Neighborhood Hits	257	Shared Neighborhood Hits	170
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G1_MOUSE
NC score	0.590441 (rank : 22)	θ value	1.29631e-06 (rank : 29)
Query Neighborhood Hits	329	Target Neighborhood Hits	291	Shared Neighborhood Hits	165
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G1_HUMAN
NC score	0.587454 (rank : 23)	θ value	1.29631e-06 (rank : 28)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	165
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SRBS1_MOUSE
NC score	0.587034 (rank : 24)	θ value	9.29e-05 (rank : 66)
Query Neighborhood Hits	329	Target Neighborhood Hits	409	Shared Neighborhood Hits	196
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.582053 (rank : 25)	θ value	0.000121331 (rank : 73)
Query Neighborhood Hits	329	Target Neighborhood Hits	396	Shared Neighborhood Hits	190
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN2_HUMAN
NC score	0.581167 (rank : 26)	θ value	4.45536e-07 (rank : 22)
Query Neighborhood Hits	329	Target Neighborhood Hits	339	Shared Neighborhood Hits	173
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.581095 (rank : 27)	θ value	8.97725e-08 (rank : 14)
Query Neighborhood Hits	329	Target Neighborhood Hits	382	Shared Neighborhood Hits	172
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAC_HUMAN
NC score	0.572387 (rank : 28)	θ value	3.77169e-06 (rank : 37)
Query Neighborhood Hits	329	Target Neighborhood Hits	276	Shared Neighborhood Hits	160
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PACN1_MOUSE
NC score	0.571818 (rank : 29)	θ value	5.81887e-07 (rank : 24)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	166
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

NCF4_MOUSE
NC score	0.570677 (rank : 30)	θ value	0.000158464 (rank : 77)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	137
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_HUMAN
NC score	0.567195 (rank : 31)	θ value	1.43324e-05 (rank : 49)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	174
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN1_HUMAN
NC score	0.566824 (rank : 32)	θ value	5.81887e-07 (rank : 23)
Query Neighborhood Hits	329	Target Neighborhood Hits	320	Shared Neighborhood Hits	166
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

STAM1_MOUSE
NC score	0.564869 (rank : 33)	θ value	1.87187e-05 (rank : 52)
Query Neighborhood Hits	329	Target Neighborhood Hits	273	Shared Neighborhood Hits	175
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_MOUSE
NC score	0.556842 (rank : 34)	θ value	3.19293e-05 (rank : 55)
Query Neighborhood Hits	329	Target Neighborhood Hits	268	Shared Neighborhood Hits	159
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP2_MOUSE
NC score	0.555904 (rank : 35)	θ value	1.87187e-05 (rank : 50)
Query Neighborhood Hits	329	Target Neighborhood Hits	297	Shared Neighborhood Hits	175
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.552469 (rank : 36)	θ value	1.43324e-05 (rank : 46)
Query Neighborhood Hits	329	Target Neighborhood Hits	304	Shared Neighborhood Hits	178
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_HUMAN
NC score	0.548992 (rank : 37)	θ value	1.43324e-05 (rank : 47)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	173
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.548685 (rank : 38)	θ value	1.43324e-05 (rank : 48)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	173
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF4_HUMAN
NC score	0.547347 (rank : 39)	θ value	0.000158464 (rank : 76)
Query Neighborhood Hits	329	Target Neighborhood Hits	161	Shared Neighborhood Hits	127
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM2_MOUSE
NC score	0.545487 (rank : 40)	θ value	9.29e-05 (rank : 68)
Query Neighborhood Hits	329	Target Neighborhood Hits	285	Shared Neighborhood Hits	167
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

LASP1_HUMAN
NC score	0.541444 (rank : 41)	θ value	1.29631e-06 (rank : 26)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	147
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PPIP1_MOUSE
NC score	0.538407 (rank : 42)	θ value	0.00020696 (rank : 80)
Query Neighborhood Hits	329	Target Neighborhood Hits	377	Shared Neighborhood Hits	175
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PACN3_MOUSE
NC score	0.538400 (rank : 43)	θ value	6.43352e-06 (rank : 42)
Query Neighborhood Hits	329	Target Neighborhood Hits	380	Shared Neighborhood Hits	163
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

LASP1_MOUSE
NC score	0.537094 (rank : 44)	θ value	1.29631e-06 (rank : 27)
Query Neighborhood Hits	329	Target Neighborhood Hits	297	Shared Neighborhood Hits	146
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCK2_HUMAN
NC score	0.534598 (rank : 45)	θ value	8.40245e-06 (rank : 43)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	169
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAM2_HUMAN
NC score	0.534574 (rank : 46)	θ value	0.000121331 (rank : 74)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	173
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

NCK1_HUMAN
NC score	0.533026 (rank : 47)	θ value	0.000121331 (rank : 72)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	172
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

PACN3_HUMAN
NC score	0.532000 (rank : 48)	θ value	6.43352e-06 (rank : 41)
Query Neighborhood Hits	329	Target Neighborhood Hits	385	Shared Neighborhood Hits	160
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PPIP1_HUMAN
NC score	0.528226 (rank : 49)	θ value	0.00102713 (rank : 98)
Query Neighborhood Hits	329	Target Neighborhood Hits	389	Shared Neighborhood Hits	173
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI3_MOUSE
NC score	0.525935 (rank : 50)	θ value	0.0148317 (rank : 119)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	147
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

GRAP_HUMAN
NC score	0.523953 (rank : 51)	θ value	7.1131e-05 (rank : 61)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	174
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.523065 (rank : 52)	θ value	0.000158464 (rank : 75)
Query Neighborhood Hits	329	Target Neighborhood Hits	309	Shared Neighborhood Hits	173
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ARHG7_MOUSE
NC score	0.521740 (rank : 53)	θ value	4.1701e-05 (rank : 57)
Query Neighborhood Hits	329	Target Neighborhood Hits	396	Shared Neighborhood Hits	170
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.516881 (rank : 54)	θ value	2.44474e-05 (rank : 53)
Query Neighborhood Hits	329	Target Neighborhood Hits	347	Shared Neighborhood Hits	167
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

STAC3_MOUSE
NC score	0.516781 (rank : 55)	θ value	0.00020696 (rank : 83)
Query Neighborhood Hits	329	Target Neighborhood Hits	232	Shared Neighborhood Hits	148
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ABI3_HUMAN
NC score	0.515443 (rank : 56)	θ value	0.0330416 (rank : 126)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	143
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC3_HUMAN
NC score	0.515317 (rank : 57)	θ value	0.00020696 (rank : 82)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	147
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

DNMBP_HUMAN
NC score	0.503883 (rank : 58)	θ value	0.000270298 (rank : 86)
Query Neighborhood Hits	329	Target Neighborhood Hits	413	Shared Neighborhood Hits	183
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.497481 (rank : 59)	θ value	1.43324e-05 (rank : 45)
Query Neighborhood Hits	329	Target Neighborhood Hits	435	Shared Neighborhood Hits	190
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_MOUSE
NC score	0.489655 (rank : 60)	θ value	0.000786445 (rank : 93)
Query Neighborhood Hits	329	Target Neighborhood Hits	394	Shared Neighborhood Hits	167
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG6_HUMAN
NC score	0.484666 (rank : 61)	θ value	0.000786445 (rank : 92)
Query Neighborhood Hits	329	Target Neighborhood Hits	376	Shared Neighborhood Hits	166
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

NEBL_HUMAN
NC score	0.483495 (rank : 62)	θ value	6.43352e-06 (rank : 40)
Query Neighborhood Hits	329	Target Neighborhood Hits	457	Shared Neighborhood Hits	156
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CT032_HUMAN
NC score	0.479917 (rank : 63)	θ value	0.00020696 (rank : 79)
Query Neighborhood Hits	329	Target Neighborhood Hits	235	Shared Neighborhood Hits	137
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

NCF1_MOUSE
NC score	0.478884 (rank : 64)	θ value	0.125558 (rank : 155)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	150
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.477534 (rank : 65)	θ value	0.0736092 (rank : 142)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	144
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CRKL_HUMAN
NC score	0.474768 (rank : 66)	θ value	0.00665767 (rank : 112)
Query Neighborhood Hits	329	Target Neighborhood Hits	313	Shared Neighborhood Hits	166
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

OSTF1_HUMAN
NC score	0.472896 (rank : 67)	θ value	3.77169e-06 (rank : 35)
Query Neighborhood Hits	329	Target Neighborhood Hits	466	Shared Neighborhood Hits	172
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
NC score	0.471239 (rank : 68)	θ value	2.61198e-07 (rank : 18)
Query Neighborhood Hits	329	Target Neighborhood Hits	467	Shared Neighborhood Hits	173
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CRKL_MOUSE
NC score	0.465228 (rank : 69)	θ value	0.0113563 (rank : 116)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	162
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.446723 (rank : 70)	θ value	0.0961366 (rank : 147)
Query Neighborhood Hits	329	Target Neighborhood Hits	314	Shared Neighborhood Hits	164
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

VAV_MOUSE
NC score	0.445006 (rank : 71)	θ value	7.1131e-05 (rank : 64)
Query Neighborhood Hits	329	Target Neighborhood Hits	430	Shared Neighborhood Hits	168
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.443618 (rank : 72)	θ value	9.29e-05 (rank : 69)
Query Neighborhood Hits	329	Target Neighborhood Hits	452	Shared Neighborhood Hits	170
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

BCAR1_MOUSE
NC score	0.442069 (rank : 73)	θ value	0.000461057 (rank : 88)
Query Neighborhood Hits	329	Target Neighborhood Hits	438	Shared Neighborhood Hits	191
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.440587 (rank : 74)	θ value	0.00035302 (rank : 87)
Query Neighborhood Hits	329	Target Neighborhood Hits	554	Shared Neighborhood Hits	201
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CRK_HUMAN
NC score	0.440371 (rank : 75)	θ value	0.0961366 (rank : 146)
Query Neighborhood Hits	329	Target Neighborhood Hits	308	Shared Neighborhood Hits	162
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEBU_HUMAN
NC score	0.436733 (rank : 76)	θ value	8.40245e-06 (rank : 44)
Query Neighborhood Hits	329	Target Neighborhood Hits	420	Shared Neighborhood Hits	161
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NPHP1_MOUSE
NC score	0.430016 (rank : 77)	θ value	0.0961366 (rank : 152)
Query Neighborhood Hits	329	Target Neighborhood Hits	267	Shared Neighborhood Hits	151
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ITSN2_HUMAN
NC score	0.423297 (rank : 78)	θ value	6.87365e-08 (rank : 12)
Query Neighborhood Hits	329	Target Neighborhood Hits	1173	Shared Neighborhood Hits	199
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV2_MOUSE
NC score	0.418801 (rank : 79)	θ value	0.000461057 (rank : 90)
Query Neighborhood Hits	329	Target Neighborhood Hits	456	Shared Neighborhood Hits	166
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.417586 (rank : 80)	θ value	0.000461057 (rank : 89)
Query Neighborhood Hits	329	Target Neighborhood Hits	453	Shared Neighborhood Hits	165
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CASL_HUMAN
NC score	0.413350 (rank : 81)	θ value	0.000270298 (rank : 84)
Query Neighborhood Hits	329	Target Neighborhood Hits	259	Shared Neighborhood Hits	152
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.413119 (rank : 82)	θ value	0.000270298 (rank : 85)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	146
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PLCG1_MOUSE
NC score	0.412578 (rank : 83)	θ value	3.77169e-06 (rank : 36)
Query Neighborhood Hits	329	Target Neighborhood Hits	314	Shared Neighborhood Hits	150
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

AHI1_MOUSE
NC score	0.409294 (rank : 84)	θ value	4.1701e-05 (rank : 56)
Query Neighborhood Hits	329	Target Neighborhood Hits	496	Shared Neighborhood Hits	172
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AHI1_HUMAN
NC score	0.409007 (rank : 85)	θ value	0.00020696 (rank : 78)
Query Neighborhood Hits	329	Target Neighborhood Hits	537	Shared Neighborhood Hits	172
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

EFS_MOUSE
NC score	0.406499 (rank : 86)	θ value	0.0736092 (rank : 140)
Query Neighborhood Hits	329	Target Neighborhood Hits	389	Shared Neighborhood Hits	176
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN1_HUMAN
NC score	0.405656 (rank : 87)	θ value	7.34386e-10 (rank : 7)
Query Neighborhood Hits	329	Target Neighborhood Hits	1757	Shared Neighborhood Hits	229
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.405612 (rank : 88)	θ value	4.76016e-09 (rank : 8)
Query Neighborhood Hits	329	Target Neighborhood Hits	1669	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_MOUSE
NC score	0.403431 (rank : 89)	θ value	1.17247e-07 (rank : 16)
Query Neighborhood Hits	329	Target Neighborhood Hits	1371	Shared Neighborhood Hits	198
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

EFS_HUMAN
NC score	0.401860 (rank : 90)	θ value	0.0736092 (rank : 139)
Query Neighborhood Hits	329	Target Neighborhood Hits	348	Shared Neighborhood Hits	173
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

VAV3_HUMAN
NC score	0.397852 (rank : 91)	θ value	0.00134147 (rank : 100)
Query Neighborhood Hits	329	Target Neighborhood Hits	398	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PLCG1_HUMAN
NC score	0.395283 (rank : 92)	θ value	1.87187e-05 (rank : 51)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	146
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV3_MOUSE
NC score	0.390000 (rank : 93)	θ value	0.00228821 (rank : 102)
Query Neighborhood Hits	329	Target Neighborhood Hits	404	Shared Neighborhood Hits	169
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PLCG2_HUMAN
NC score	0.388439 (rank : 94)	θ value	0.00134147 (rank : 99)
Query Neighborhood Hits	329	Target Neighborhood Hits	280	Shared Neighborhood Hits	148
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ARHG4_HUMAN
NC score	0.379419 (rank : 95)	θ value	0.00509761 (rank : 108)
Query Neighborhood Hits	329	Target Neighborhood Hits	242	Shared Neighborhood Hits	149
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NPHP1_HUMAN
NC score	0.375650 (rank : 96)	θ value	0.365318 (rank : 166)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	139
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SNX18_MOUSE
NC score	0.370693 (rank : 97)	θ value	0.00509761 (rank : 110)
Query Neighborhood Hits	329	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_HUMAN
NC score	0.367259 (rank : 98)	θ value	0.00509761 (rank : 109)
Query Neighborhood Hits	329	Target Neighborhood Hits	207	Shared Neighborhood Hits	124
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG9_MOUSE
NC score	0.366040 (rank : 99)	θ value	0.000786445 (rank : 95)
Query Neighborhood Hits	329	Target Neighborhood Hits	234	Shared Neighborhood Hits	143
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.363462 (rank : 100)	θ value	0.000786445 (rank : 94)
Query Neighborhood Hits	329	Target Neighborhood Hits	235	Shared Neighborhood Hits	143
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

RHG04_HUMAN
NC score	0.354895 (rank : 101)	θ value	2.88788e-06 (rank : 34)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NOXO1_MOUSE
NC score	0.352644 (rank : 102)	θ value	0.0431538 (rank : 134)
Query Neighborhood Hits	329	Target Neighborhood Hits	114	Shared Neighborhood Hits	99
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PEX13_HUMAN
NC score	0.340097 (rank : 103)	θ value	2.36792 (rank : 227)
Query Neighborhood Hits	329	Target Neighborhood Hits	128	Shared Neighborhood Hits	106
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.338399 (rank : 104)	θ value	3.0926 (rank : 244)
Query Neighborhood Hits	329	Target Neighborhood Hits	126	Shared Neighborhood Hits	106
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_HUMAN
NC score	0.331614 (rank : 105)	θ value	0.279714 (rank : 162)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	140
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
NC score	0.324641 (rank : 106)	θ value	0.0113563 (rank : 117)
Query Neighborhood Hits	329	Target Neighborhood Hits	206	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SRGP2_MOUSE
NC score	0.319181 (rank : 107)	θ value	9.29e-05 (rank : 67)
Query Neighborhood Hits	329	Target Neighborhood Hits	324	Shared Neighborhood Hits	146
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.314671 (rank : 108)	θ value	7.1131e-05 (rank : 63)
Query Neighborhood Hits	329	Target Neighborhood Hits	331	Shared Neighborhood Hits	145
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SHLB1_MOUSE
NC score	0.307978 (rank : 109)	θ value	0.0736092 (rank : 145)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB1_HUMAN
NC score	0.303468 (rank : 110)	θ value	0.0736092 (rank : 144)
Query Neighborhood Hits	329	Target Neighborhood Hits	96	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SRGP1_HUMAN
NC score	0.299228 (rank : 111)	θ value	0.000786445 (rank : 97)
Query Neighborhood Hits	329	Target Neighborhood Hits	390	Shared Neighborhood Hits	143
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

IASPP_HUMAN
NC score	0.298874 (rank : 112)	θ value	0.163984 (rank : 157)
Query Neighborhood Hits	329	Target Neighborhood Hits	688	Shared Neighborhood Hits	179
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

FNBP2_HUMAN
NC score	0.298000 (rank : 113)	θ value	0.00665767 (rank : 113)
Query Neighborhood Hits	329	Target Neighborhood Hits	432	Shared Neighborhood Hits	153
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ARHG4_MOUSE
NC score	0.292277 (rank : 114)	θ value	0.62314 (rank : 175)
Query Neighborhood Hits	329	Target Neighborhood Hits	185	Shared Neighborhood Hits	107
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

RHG26_HUMAN
NC score	0.287123 (rank : 115)	θ value	0.0330416 (rank : 129)
Query Neighborhood Hits	329	Target Neighborhood Hits	281	Shared Neighborhood Hits	132
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ASPP1_MOUSE
NC score	0.286896 (rank : 116)	θ value	0.00869519 (rank : 115)
Query Neighborhood Hits	329	Target Neighborhood Hits	1244	Shared Neighborhood Hits	221
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.284126 (rank : 117)	θ value	0.00665767 (rank : 111)
Query Neighborhood Hits	329	Target Neighborhood Hits	956	Shared Neighborhood Hits	180
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MYO1F_HUMAN
NC score	0.277860 (rank : 118)	θ value	3.41135e-07 (rank : 20)
Query Neighborhood Hits	329	Target Neighborhood Hits	275	Shared Neighborhood Hits	168
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.276864 (rank : 119)	θ value	4.45536e-07 (rank : 21)
Query Neighborhood Hits	329	Target Neighborhood Hits	262	Shared Neighborhood Hits	166
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

IASPP_MOUSE
NC score	0.276713 (rank : 120)	θ value	0.125558 (rank : 153)
Query Neighborhood Hits	329	Target Neighborhood Hits	1024	Shared Neighborhood Hits	209
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANM2_HUMAN
NC score	0.275703 (rank : 121)	θ value	0.62314 (rank : 174)
Query Neighborhood Hits	329	Target Neighborhood Hits	175	Shared Neighborhood Hits	140
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

NOXO1_HUMAN
NC score	0.270834 (rank : 122)	θ value	0.0431538 (rank : 133)
Query Neighborhood Hits	329	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

MYO1E_HUMAN
NC score	0.268959 (rank : 123)	θ value	8.97725e-08 (rank : 13)
Query Neighborhood Hits	329	Target Neighborhood Hits	293	Shared Neighborhood Hits	169
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

DDEF1_MOUSE
NC score	0.265370 (rank : 124)	θ value	0.0252991 (rank : 123)
Query Neighborhood Hits	329	Target Neighborhood Hits	592	Shared Neighborhood Hits	158
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SHLB2_MOUSE
NC score	0.262272 (rank : 125)	θ value	0.813845 (rank : 186)
Query Neighborhood Hits	329	Target Neighborhood Hits	88	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

RIMB2_HUMAN
NC score	0.262106 (rank : 126)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	329	Target Neighborhood Hits	263	Shared Neighborhood Hits	113
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SHLB2_HUMAN
NC score	0.260234 (rank : 127)	θ value	0.813845 (rank : 185)
Query Neighborhood Hits	329	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

TCGAP_MOUSE
NC score	0.258436 (rank : 128)	θ value	0.00298849 (rank : 105)
Query Neighborhood Hits	329	Target Neighborhood Hits	409	Shared Neighborhood Hits	132
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ANM2_MOUSE
NC score	0.256888 (rank : 129)	θ value	1.38821 (rank : 193)
Query Neighborhood Hits	329	Target Neighborhood Hits	175	Shared Neighborhood Hits	136
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RIMB2_MOUSE
NC score	0.256213 (rank : 130)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	329	Target Neighborhood Hits	246	Shared Neighborhood Hits	106
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA2_HUMAN
NC score	0.254516 (rank : 131)	θ value	7.1131e-05 (rank : 62)
Query Neighborhood Hits	329	Target Neighborhood Hits	888	Shared Neighborhood Hits	169
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTA1_MOUSE
NC score	0.247137 (rank : 132)	θ value	5.44631e-05 (rank : 60)
Query Neighborhood Hits	329	Target Neighborhood Hits	675	Shared Neighborhood Hits	158
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TCGAP_HUMAN
NC score	0.243088 (rank : 133)	θ value	0.00298849 (rank : 104)
Query Neighborhood Hits	329	Target Neighborhood Hits	872	Shared Neighborhood Hits	170
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SPTA1_HUMAN
NC score	0.240506 (rank : 134)	θ value	0.00020696 (rank : 81)
Query Neighborhood Hits	329	Target Neighborhood Hits	748	Shared Neighborhood Hits	165
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

DDEF2_MOUSE
NC score	0.232564 (rank : 135)	θ value	0.365318 (rank : 164)
Query Neighborhood Hits	329	Target Neighborhood Hits	625	Shared Neighborhood Hits	151
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.230983 (rank : 136)	θ value	0.365318 (rank : 163)
Query Neighborhood Hits	329	Target Neighborhood Hits	599	Shared Neighborhood Hits	159
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SHAN2_MOUSE
NC score	0.222839 (rank : 137)	θ value	0.0563607 (rank : 138)
Query Neighborhood Hits	329	Target Neighborhood Hits	446	Shared Neighborhood Hits	121
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ES8L3_MOUSE
NC score	0.217723 (rank : 138)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	329	Target Neighborhood Hits	168	Shared Neighborhood Hits	134
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ASPP2_HUMAN
NC score	0.212902 (rank : 139)	θ value	1.06291 (rank : 189)
Query Neighborhood Hits	329	Target Neighborhood Hits	1156	Shared Neighborhood Hits	180
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

DOCK1_HUMAN
NC score	0.210690 (rank : 140)	θ value	0.00228821 (rank : 101)
Query Neighborhood Hits	329	Target Neighborhood Hits	191	Shared Neighborhood Hits	111
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

AMPH_HUMAN
NC score	0.204309 (rank : 141)	θ value	0.0252991 (rank : 122)
Query Neighborhood Hits	329	Target Neighborhood Hits	455	Shared Neighborhood Hits	119
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

SNX9_HUMAN
NC score	0.202828 (rank : 142)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	329	Target Neighborhood Hits	148	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

AMPH_MOUSE
NC score	0.200106 (rank : 143)	θ value	0.62314 (rank : 173)
Query Neighborhood Hits	329	Target Neighborhood Hits	291	Shared Neighborhood Hits	89
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ES8L3_HUMAN
NC score	0.199380 (rank : 144)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	329	Target Neighborhood Hits	206	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3KL4_HUMAN
NC score	0.186990 (rank : 145)	θ value	4.92598e-06 (rank : 38)
Query Neighborhood Hits	329	Target Neighborhood Hits	1087	Shared Neighborhood Hits	183
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPN90_HUMAN
NC score	0.185338 (rank : 146)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STS2_HUMAN
NC score	0.183421 (rank : 147)	θ value	2.36792 (rank : 230)
Query Neighborhood Hits	329	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ES8L2_HUMAN
NC score	0.181078 (rank : 148)	θ value	0.813845 (rank : 183)
Query Neighborhood Hits	329	Target Neighborhood Hits	193	Shared Neighborhood Hits	121
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHG5_HUMAN
NC score	0.180063 (rank : 149)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	329	Target Neighborhood Hits	172	Shared Neighborhood Hits	84
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SNX9_MOUSE
NC score	0.179300 (rank : 150)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	329	Target Neighborhood Hits	141	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SHAN1_HUMAN
NC score	0.178177 (rank : 151)	θ value	0.0563607 (rank : 137)
Query Neighborhood Hits	329	Target Neighborhood Hits	1041	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

P85A_MOUSE
NC score	0.171940 (rank : 152)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	329	Target Neighborhood Hits	435	Shared Neighborhood Hits	112
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

M3K11_HUMAN
NC score	0.171904 (rank : 153)	θ value	3.19293e-05 (rank : 54)
Query Neighborhood Hits	329	Target Neighborhood Hits	1136	Shared Neighborhood Hits	188
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

FGR_HUMAN
NC score	0.171420 (rank : 154)	θ value	0.00298849 (rank : 103)
Query Neighborhood Hits	329	Target Neighborhood Hits	1067	Shared Neighborhood Hits	169
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_MOUSE
NC score	0.171066 (rank : 155)	θ value	0.0252991 (rank : 125)
Query Neighborhood Hits	329	Target Neighborhood Hits	1073	Shared Neighborhood Hits	174
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ES8L2_MOUSE
NC score	0.170280 (rank : 156)	θ value	8.99809 (rank : 311)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	116
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FYN_HUMAN
NC score	0.168033 (rank : 157)	θ value	0.0252991 (rank : 124)
Query Neighborhood Hits	329	Target Neighborhood Hits	1078	Shared Neighborhood Hits	174
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

YES_MOUSE
NC score	0.167138 (rank : 158)	θ value	0.0113563 (rank : 118)
Query Neighborhood Hits	329	Target Neighborhood Hits	1052	Shared Neighborhood Hits	170
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPS8_MOUSE
NC score	0.166546 (rank : 159)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	115
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

FGR_MOUSE
NC score	0.165931 (rank : 160)	θ value	0.000121331 (rank : 71)
Query Neighborhood Hits	329	Target Neighborhood Hits	1069	Shared Neighborhood Hits	171
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.165418 (rank : 161)	θ value	0.0330416 (rank : 130)
Query Neighborhood Hits	329	Target Neighborhood Hits	1059	Shared Neighborhood Hits	172
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_HUMAN
NC score	0.164621 (rank : 162)	θ value	0.00390308 (rank : 106)
Query Neighborhood Hits	329	Target Neighborhood Hits	1058	Shared Neighborhood Hits	175
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

M3K9_HUMAN
NC score	0.164099 (rank : 163)	θ value	9.29e-05 (rank : 65)
Query Neighborhood Hits	329	Target Neighborhood Hits	1123	Shared Neighborhood Hits	181
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

NGEF_MOUSE
NC score	0.163573 (rank : 164)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

SPN90_MOUSE
NC score	0.163109 (rank : 165)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

P85A_HUMAN
NC score	0.162662 (rank : 166)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	329	Target Neighborhood Hits	479	Shared Neighborhood Hits	108
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SLAP2_MOUSE
NC score	0.162016 (rank : 167)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	329	Target Neighborhood Hits	136	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.161874 (rank : 168)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	329	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

NGEF_HUMAN
NC score	0.161707 (rank : 169)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	78
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RIMB1_HUMAN
NC score	0.157333 (rank : 170)	θ value	6.88961 (rank : 300)
Query Neighborhood Hits	329	Target Neighborhood Hits	1479	Shared Neighborhood Hits	182
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

EPS8_HUMAN
NC score	0.156450 (rank : 171)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	101
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

CIP4_HUMAN
NC score	0.156047 (rank : 172)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	329	Target Neighborhood Hits	374	Shared Neighborhood Hits	75
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

ES8L1_HUMAN
NC score	0.152336 (rank : 173)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	329	Target Neighborhood Hits	162	Shared Neighborhood Hits	98
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RIMB1_MOUSE
NC score	0.151878 (rank : 174)	θ value	4.03905 (rank : 259)
Query Neighborhood Hits	329	Target Neighborhood Hits	1376	Shared Neighborhood Hits	176
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

M3K10_HUMAN
NC score	0.150834 (rank : 175)	θ value	0.000602161 (rank : 91)
Query Neighborhood Hits	329	Target Neighborhood Hits	1071	Shared Neighborhood Hits	163
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

BIN1_HUMAN
NC score	0.149995 (rank : 176)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	329	Target Neighborhood Hits	335	Shared Neighborhood Hits	87
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

STS1_MOUSE
NC score	0.149647 (rank : 177)	θ value	8.99809 (rank : 327)
Query Neighborhood Hits	329	Target Neighborhood Hits	104	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BIN1_MOUSE
NC score	0.148100 (rank : 178)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	92
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

SLAP1_HUMAN
NC score	0.147399 (rank : 179)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	329	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

HCK_MOUSE
NC score	0.146229 (rank : 180)	θ value	0.0961366 (rank : 149)
Query Neighborhood Hits	329	Target Neighborhood Hits	1029	Shared Neighborhood Hits	167
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SLAP1_MOUSE
NC score	0.145695 (rank : 181)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	329	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

STS1_HUMAN
NC score	0.145572 (rank : 182)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	329	Target Neighborhood Hits	106	Shared Neighborhood Hits	71
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

P85B_HUMAN
NC score	0.145097 (rank : 183)	θ value	0.0736092 (rank : 143)
Query Neighborhood Hits	329	Target Neighborhood Hits	543	Shared Neighborhood Hits	90
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ES8L1_MOUSE
NC score	0.144568 (rank : 184)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	329	Target Neighborhood Hits	143	Shared Neighborhood Hits	91
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

BTK_HUMAN
NC score	0.144391 (rank : 185)	θ value	0.62314 (rank : 177)
Query Neighborhood Hits	329	Target Neighborhood Hits	1026	Shared Neighborhood Hits	170
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

HCK_HUMAN
NC score	0.144108 (rank : 186)	θ value	0.0563607 (rank : 136)
Query Neighborhood Hits	329	Target Neighborhood Hits	1035	Shared Neighborhood Hits	168
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.142391 (rank : 187)	θ value	0.163984 (rank : 159)
Query Neighborhood Hits	329	Target Neighborhood Hits	1033	Shared Neighborhood Hits	160
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FRK_HUMAN
NC score	0.138602 (rank : 188)	θ value	0.0193708 (rank : 121)
Query Neighborhood Hits	329	Target Neighborhood Hits	1058	Shared Neighborhood Hits	171
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ARHGG_MOUSE
NC score	0.138547 (rank : 189)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	329	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BTK_MOUSE
NC score	0.136756 (rank : 190)	θ value	2.36792 (rank : 218)
Query Neighborhood Hits	329	Target Neighborhood Hits	1017	Shared Neighborhood Hits	160
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PKHG1_HUMAN
NC score	0.134396 (rank : 191)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	28
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

RASA1_HUMAN
NC score	0.131022 (rank : 192)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	329	Target Neighborhood Hits	258	Shared Neighborhood Hits	63
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LYN_HUMAN
NC score	0.128789 (rank : 193)	θ value	2.36792 (rank : 223)
Query Neighborhood Hits	329	Target Neighborhood Hits	1022	Shared Neighborhood Hits	153
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.128205 (rank : 194)	θ value	1.81305 (rank : 209)
Query Neighborhood Hits	329	Target Neighborhood Hits	1023	Shared Neighborhood Hits	154
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PREX1_HUMAN
NC score	0.128091 (rank : 195)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

MCF2L_MOUSE
NC score	0.127833 (rank : 196)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	329	Target Neighborhood Hits	255	Shared Neighborhood Hits	47
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

P85B_MOUSE
NC score	0.127398 (rank : 197)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	329	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

TIAM1_HUMAN
NC score	0.124506 (rank : 198)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.124446 (rank : 199)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	329	Target Neighborhood Hits	205	Shared Neighborhood Hits	28
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_HUMAN
NC score	0.123862 (rank : 200)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	329	Target Neighborhood Hits	82	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.123668 (rank : 201)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	329	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

CSK_MOUSE
NC score	0.122913 (rank : 202)	θ value	0.0330416 (rank : 128)
Query Neighborhood Hits	329	Target Neighborhood Hits	1009	Shared Neighborhood Hits	133
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.122873 (rank : 203)	θ value	0.0330416 (rank : 127)
Query Neighborhood Hits	329	Target Neighborhood Hits	1009	Shared Neighborhood Hits	133
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ARHGG_HUMAN
NC score	0.121353 (rank : 204)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	329	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG8_MOUSE
NC score	0.119809 (rank : 205)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	329	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TEC_HUMAN
NC score	0.118640 (rank : 206)	θ value	0.47712 (rank : 171)
Query Neighborhood Hits	329	Target Neighborhood Hits	1006	Shared Neighborhood Hits	135
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_MOUSE
NC score	0.117800 (rank : 207)	θ value	1.06291 (rank : 192)
Query Neighborhood Hits	329	Target Neighborhood Hits	980	Shared Neighborhood Hits	130
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

BLK_HUMAN
NC score	0.117799 (rank : 208)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	329	Target Neighborhood Hits	994	Shared Neighborhood Hits	136
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DAPP1_MOUSE
NC score	0.117699 (rank : 209)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SLY_MOUSE
NC score	0.117037 (rank : 210)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	329	Target Neighborhood Hits	108	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

DAPP1_HUMAN
NC score	0.116973 (rank : 211)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

TEC_MOUSE
NC score	0.113990 (rank : 212)	θ value	0.813845 (rank : 188)
Query Neighborhood Hits	329	Target Neighborhood Hits	1006	Shared Neighborhood Hits	136
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ARHG8_HUMAN
NC score	0.113218 (rank : 213)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	329	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BLK_MOUSE
NC score	0.113215 (rank : 214)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	329	Target Neighborhood Hits	992	Shared Neighborhood Hits	126
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BI2L1_HUMAN
NC score	0.111750 (rank : 215)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

RUSC2_HUMAN
NC score	0.111299 (rank : 216)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	329	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

PTK6_MOUSE
NC score	0.110060 (rank : 217)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	329	Target Neighborhood Hits	1026	Shared Neighborhood Hits	150
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

LCK_HUMAN
NC score	0.109037 (rank : 218)	θ value	8.99809 (rank : 316)
Query Neighborhood Hits	329	Target Neighborhood Hits	987	Shared Neighborhood Hits	112
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PTK6_HUMAN
NC score	0.108403 (rank : 219)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	329	Target Neighborhood Hits	1020	Shared Neighborhood Hits	153
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LCK_MOUSE
NC score	0.108101 (rank : 220)	θ value	8.99809 (rank : 317)
Query Neighborhood Hits	329	Target Neighborhood Hits	981	Shared Neighborhood Hits	111
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

ARHGA_MOUSE
NC score	0.107611 (rank : 221)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	329	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITK_HUMAN
NC score	0.107552 (rank : 222)	θ value	0.0961366 (rank : 150)
Query Neighborhood Hits	329	Target Neighborhood Hits	1016	Shared Neighborhood Hits	132
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

P55G_HUMAN
NC score	0.107386 (rank : 223)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	329	Target Neighborhood Hits	451	Shared Neighborhood Hits	56
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

ABL1_MOUSE
NC score	0.106484 (rank : 224)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	329	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

RUSC2_MOUSE
NC score	0.106469 (rank : 225)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	329	Target Neighborhood Hits	305	Shared Neighborhood Hits	86
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

P55G_MOUSE
NC score	0.106174 (rank : 226)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	329	Target Neighborhood Hits	401	Shared Neighborhood Hits	55
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

TXK_HUMAN
NC score	0.105706 (rank : 227)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	329	Target Neighborhood Hits	971	Shared Neighborhood Hits	121
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABL1_HUMAN
NC score	0.105427 (rank : 228)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	329	Target Neighborhood Hits	1220	Shared Neighborhood Hits	150
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

MCF2_HUMAN
NC score	0.105207 (rank : 229)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	27
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ITK_MOUSE
NC score	0.102294 (rank : 230)	θ value	0.125558 (rank : 154)
Query Neighborhood Hits	329	Target Neighborhood Hits	985	Shared Neighborhood Hits	119
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SH21B_MOUSE
NC score	0.101753 (rank : 231)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SLY_HUMAN
NC score	0.101410 (rank : 232)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	329	Target Neighborhood Hits	81	Shared Neighborhood Hits	50
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

ARHGA_HUMAN
NC score	0.101073 (rank : 233)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	329	Target Neighborhood Hits	187	Shared Neighborhood Hits	24
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SHE_MOUSE
NC score	0.100639 (rank : 234)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ABL2_HUMAN
NC score	0.100379 (rank : 235)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	329	Target Neighborhood Hits	1045	Shared Neighborhood Hits	125
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

SH21B_HUMAN
NC score	0.099850 (rank : 236)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	329	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

BAIP2_MOUSE
NC score	0.099182 (rank : 237)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	329	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

PPIP2_HUMAN
NC score	0.098624 (rank : 238)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	329	Target Neighborhood Hits	254	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

ECT2_MOUSE
NC score	0.098077 (rank : 239)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	329	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BCR_HUMAN
NC score	0.097837 (rank : 240)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	36
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

APS_HUMAN
NC score	0.097179 (rank : 241)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	329	Target Neighborhood Hits	162	Shared Neighborhood Hits	46
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BAIP2_HUMAN
NC score	0.096820 (rank : 242)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	329	Target Neighborhood Hits	192	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SHC3_MOUSE
NC score	0.096653 (rank : 243)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

CHIN_MOUSE
NC score	0.096480 (rank : 244)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	329	Target Neighborhood Hits	229	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SHE_HUMAN
NC score	0.096334 (rank : 245)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	329	Target Neighborhood Hits	164	Shared Neighborhood Hits	49
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_MOUSE
NC score	0.095866 (rank : 246)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CHIN_HUMAN
NC score	0.095544 (rank : 247)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CN155_HUMAN
NC score	0.094793 (rank : 248)	θ value	0.0148317 (rank : 120)
Query Neighborhood Hits	329	Target Neighborhood Hits	385	Shared Neighborhood Hits	54
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

GRB14_MOUSE
NC score	0.094595 (rank : 249)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	329	Target Neighborhood Hits	149	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ECT2_HUMAN
NC score	0.094412 (rank : 250)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	329	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BLNK_MOUSE
NC score	0.093807 (rank : 251)	θ value	0.813845 (rank : 182)
Query Neighborhood Hits	329	Target Neighborhood Hits	296	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CHIO_HUMAN
NC score	0.093649 (rank : 252)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	329	Target Neighborhood Hits	220	Shared Neighborhood Hits	46
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SHB_HUMAN
NC score	0.093543 (rank : 253)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	329	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

DREB_MOUSE
NC score	0.093451 (rank : 254)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	329	Target Neighborhood Hits	446	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

GRB14_HUMAN
NC score	0.092695 (rank : 255)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC1_HUMAN
NC score	0.092353 (rank : 256)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	329	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
NC score	0.091514 (rank : 257)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	329	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

LCP2_HUMAN
NC score	0.091479 (rank : 258)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	329	Target Neighborhood Hits	531	Shared Neighborhood Hits	98
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ARHGB_HUMAN
NC score	0.090913 (rank : 259)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	329	Target Neighborhood Hits	375	Shared Neighborhood Hits	32
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.090838 (rank : 260)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	329	Target Neighborhood Hits	351	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG1_HUMAN
NC score	0.090765 (rank : 261)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	329	Target Neighborhood Hits	176	Shared Neighborhood Hits	26
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SHC3_HUMAN
NC score	0.090736 (rank : 262)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	329	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHD_HUMAN
NC score	0.090136 (rank : 263)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	51
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ARHGC_MOUSE
NC score	0.089664 (rank : 264)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	329	Target Neighborhood Hits	344	Shared Neighborhood Hits	27
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SHC2_HUMAN
NC score	0.089429 (rank : 265)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	329	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

BI2L1_MOUSE
NC score	0.089173 (rank : 266)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	329	Target Neighborhood Hits	197	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

3BP1_HUMAN
NC score	0.089170 (rank : 267)	θ value	6.88961 (rank : 279)
Query Neighborhood Hits	329	Target Neighborhood Hits	376	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

SRMS_MOUSE
NC score	0.088776 (rank : 268)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	329	Target Neighborhood Hits	964	Shared Neighborhood Hits	105
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

HSH2D_HUMAN
NC score	0.088427 (rank : 269)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	329	Target Neighborhood Hits	159	Shared Neighborhood Hits	41
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MDC1_HUMAN
NC score	0.088274 (rank : 270)	θ value	0.0736092 (rank : 141)
Query Neighborhood Hits	329	Target Neighborhood Hits	1446	Shared Neighborhood Hits	117
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

SHC2_MOUSE
NC score	0.088143 (rank : 271)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

LNK_HUMAN
NC score	0.088134 (rank : 272)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

FUT8_HUMAN
NC score	0.087884 (rank : 273)	θ value	8.99809 (rank : 312)
Query Neighborhood Hits	329	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SHD_MOUSE
NC score	0.087760 (rank : 274)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	329	Target Neighborhood Hits	137	Shared Neighborhood Hits	49
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

JIP2_HUMAN
NC score	0.087677 (rank : 275)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	329	Target Neighborhood Hits	288	Shared Neighborhood Hits	71
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ABR_HUMAN
NC score	0.087547 (rank : 276)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	329	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

PPIP2_MOUSE
NC score	0.087378 (rank : 277)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	329	Target Neighborhood Hits	308	Shared Neighborhood Hits	24
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

HAPIP_HUMAN
NC score	0.086235 (rank : 278)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	26
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

RGS3_MOUSE
NC score	0.086004 (rank : 279)	θ value	0.000786445 (rank : 96)
Query Neighborhood Hits	329	Target Neighborhood Hits	1621	Shared Neighborhood Hits	130
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

LCP2_MOUSE
NC score	0.085342 (rank : 280)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	52
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

DOCK2_HUMAN
NC score	0.085104 (rank : 281)	θ value	0.47712 (rank : 169)
Query Neighborhood Hits	329	Target Neighborhood Hits	90	Shared Neighborhood Hits	43
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

LNK_MOUSE
NC score	0.085043 (rank : 282)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	329	Target Neighborhood Hits	132	Shared Neighborhood Hits	40
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

DREB_HUMAN
NC score	0.084921 (rank : 283)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	329	Target Neighborhood Hits	450	Shared Neighborhood Hits	37
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

EM55_HUMAN
NC score	0.084351 (rank : 284)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	86
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

GRB7_MOUSE
NC score	0.083998 (rank : 285)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	329	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

RGNEF_MOUSE
NC score	0.083074 (rank : 286)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	329	Target Neighborhood Hits	641	Shared Neighborhood Hits	48
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGF_HUMAN
NC score	0.082240 (rank : 287)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	329	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

JIP2_MOUSE
NC score	0.081914 (rank : 288)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SH21A_HUMAN
NC score	0.081608 (rank : 289)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	329	Target Neighborhood Hits	89	Shared Neighborhood Hits	35
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

GNRP_MOUSE
NC score	0.081440 (rank : 290)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	329	Target Neighborhood Hits	191	Shared Neighborhood Hits	26
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

EM55_MOUSE
NC score	0.081084 (rank : 291)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	329	Target Neighborhood Hits	221	Shared Neighborhood Hits	81
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

FGD3_MOUSE
NC score	0.080904 (rank : 292)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	329	Target Neighborhood Hits	257	Shared Neighborhood Hits	29
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

SH21A_MOUSE
NC score	0.080710 (rank : 293)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	329	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

BAT2_HUMAN
NC score	0.080033 (rank : 294)	θ value	0.62314 (rank : 176)
Query Neighborhood Hits	329	Target Neighborhood Hits	931	Shared Neighborhood Hits	99
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

LBC_HUMAN
NC score	0.079740 (rank : 295)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	329	Target Neighborhood Hits	90	Shared Neighborhood Hits	19
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

SH22A_MOUSE
NC score	0.079642 (rank : 296)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SRMS_HUMAN
NC score	0.079622 (rank : 297)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	329	Target Neighborhood Hits	946	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SASH1_HUMAN
NC score	0.079014 (rank : 298)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	329	Target Neighborhood Hits	292	Shared Neighborhood Hits	72
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

FGD4_HUMAN
NC score	0.077685 (rank : 299)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	329	Target Neighborhood Hits	219	Shared Neighborhood Hits	28
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

NACAM_MOUSE
NC score	0.077595 (rank : 300)	θ value	1.81305 (rank : 211)
Query Neighborhood Hits	329	Target Neighborhood Hits	1866	Shared Neighborhood Hits	146
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MATK_MOUSE
NC score	0.077586 (rank : 301)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	329	Target Neighborhood Hits	952	Shared Neighborhood Hits	86
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FGD4_MOUSE
NC score	0.077568 (rank : 302)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHG1_MOUSE
NC score	0.077491 (rank : 303)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	329	Target Neighborhood Hits	266	Shared Neighborhood Hits	36
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PTN11_MOUSE
NC score	0.077437 (rank : 304)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.077419 (rank : 305)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	54
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

RHG09_HUMAN
NC score	0.077413 (rank : 306)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	329	Target Neighborhood Hits	186	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

MATK_HUMAN
NC score	0.076746 (rank : 307)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	329	Target Neighborhood Hits	954	Shared Neighborhood Hits	81
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

RHG12_MOUSE
NC score	0.076599 (rank : 308)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	329	Target Neighborhood Hits	204	Shared Neighborhood Hits	48
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

FGD3_HUMAN
NC score	0.075152 (rank : 309)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	329	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHG2_HUMAN
NC score	0.075032 (rank : 310)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	329	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

BLNK_HUMAN
NC score	0.074827 (rank : 311)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	329	Target Neighborhood Hits	228	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

DOCK2_MOUSE
NC score	0.074823 (rank : 312)	θ value	5.27518 (rank : 269)
Query Neighborhood Hits	329	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

JIP1_HUMAN
NC score	0.074820 (rank : 313)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SH24A_HUMAN
NC score	0.074637 (rank : 314)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	329	Target Neighborhood Hits	455	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

GRB7_HUMAN
NC score	0.074495 (rank : 315)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	46
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SH2D3_HUMAN
NC score	0.074352 (rank : 316)	θ value	5.27518 (rank : 276)
Query Neighborhood Hits	329	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

FGD2_HUMAN
NC score	0.074179 (rank : 317)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	329	Target Neighborhood Hits	151	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

3BP1_MOUSE
NC score	0.074110 (rank : 318)	θ value	5.27518 (rank : 267)
Query Neighborhood Hits	329	Target Neighborhood Hits	238	Shared Neighborhood Hits	39
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FGD1_HUMAN
NC score	0.073893 (rank : 319)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	329	Target Neighborhood Hits	367	Shared Neighborhood Hits	52
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

SH22A_HUMAN
NC score	0.073745 (rank : 320)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	329	Target Neighborhood Hits	144	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

RHG12_HUMAN
NC score	0.073714 (rank : 321)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	329	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

ARHG2_MOUSE
NC score	0.073610 (rank : 322)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	329	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

APS_MOUSE
NC score	0.073360 (rank : 323)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	329	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH2D3_MOUSE
NC score	0.073148 (rank : 324)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GRB10_MOUSE
NC score	0.072849 (rank : 325)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	329	Target Neighborhood Hits	156	Shared Neighborhood Hits	44
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

MDC1_MOUSE
NC score	0.072231 (rank : 326)	θ value	2.36792 (rank : 224)
Query Neighborhood Hits	329	Target Neighborhood Hits	998	Shared Neighborhood Hits	110
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

JIP1_MOUSE
NC score	0.071819 (rank : 327)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	329	Target Neighborhood Hits	259	Shared Neighborhood Hits	78
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

FUT8_MOUSE
NC score	0.071801 (rank : 328)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	329	Target Neighborhood Hits	115	Shared Neighborhood Hits	29
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GNRP_HUMAN
NC score	0.071795 (rank : 329)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	329	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GRB10_HUMAN
NC score	0.071320 (rank : 330)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	329	Target Neighborhood Hits	147	Shared Neighborhood Hits	42
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

MPP6_HUMAN
NC score	0.070405 (rank : 331)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	329	Target Neighborhood Hits	180	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

SASH1_MOUSE
NC score	0.070224 (rank : 332)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	329	Target Neighborhood Hits	263	Shared Neighborhood Hits	65
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

FGD2_MOUSE
NC score	0.070048 (rank : 333)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	329	Target Neighborhood Hits	163	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_MOUSE
NC score	0.069798 (rank : 334)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	329	Target Neighborhood Hits	387	Shared Neighborhood Hits	46
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FER_HUMAN
NC score	0.069520 (rank : 335)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	329	Target Neighborhood Hits	1278	Shared Neighborhood Hits	86
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

MPP6_MOUSE
NC score	0.067315 (rank : 336)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	329	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NCOA6_HUMAN
NC score	0.067274 (rank : 337)	θ value	3.0926 (rank : 242)
Query Neighborhood Hits	329	Target Neighborhood Hits	1202	Shared Neighborhood Hits	108
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PTN6_MOUSE
NC score	0.067268 (rank : 338)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	329	Target Neighborhood Hits	225	Shared Neighborhood Hits	53
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

PCLO_HUMAN
NC score	0.067079 (rank : 339)	θ value	5.27518 (rank : 273)
Query Neighborhood Hits	329	Target Neighborhood Hits	2046	Shared Neighborhood Hits	148
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

BAT2_MOUSE
NC score	0.066943 (rank : 340)	θ value	3.0926 (rank : 235)
Query Neighborhood Hits	329	Target Neighborhood Hits	947	Shared Neighborhood Hits	90
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

ACK1_HUMAN
NC score	0.066290 (rank : 341)	θ value	8.99809 (rank : 305)
Query Neighborhood Hits	329	Target Neighborhood Hits	1140	Shared Neighborhood Hits	118
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

BCAR3_HUMAN
NC score	0.066237 (rank : 342)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	329	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

SON_HUMAN
NC score	0.066207 (rank : 343)	θ value	0.365318 (rank : 168)
Query Neighborhood Hits	329	Target Neighborhood Hits	1568	Shared Neighborhood Hits	129
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ACK1_MOUSE
NC score	0.066195 (rank : 344)	θ value	8.99809 (rank : 306)
Query Neighborhood Hits	329	Target Neighborhood Hits	1080	Shared Neighborhood Hits	121
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

CHIO_MOUSE
NC score	0.066010 (rank : 345)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	329	Target Neighborhood Hits	130	Shared Neighborhood Hits	22
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

BCAR3_MOUSE
NC score	0.065986 (rank : 346)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	329	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

PTN6_HUMAN
NC score	0.065923 (rank : 347)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	329	Target Neighborhood Hits	234	Shared Neighborhood Hits	53
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SAMN1_HUMAN
NC score	0.065537 (rank : 348)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	329	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

BMX_MOUSE
NC score	0.065231 (rank : 349)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	329	Target Neighborhood Hits	912	Shared Neighborhood Hits	59
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

FARP2_MOUSE
NC score	0.065046 (rank : 350)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	329	Target Neighborhood Hits	209	Shared Neighborhood Hits	29
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

BMX_HUMAN
NC score	0.064991 (rank : 351)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	329	Target Neighborhood Hits	942	Shared Neighborhood Hits	59
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

PRR12_HUMAN
NC score	0.064868 (rank : 352)	θ value	4.03905 (rank : 256)
Query Neighborhood Hits	329	Target Neighborhood Hits	460	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

KSYK_MOUSE
NC score	0.064658 (rank : 353)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	329	Target Neighborhood Hits	944	Shared Neighborhood Hits	66
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_MOUSE
NC score	0.064367 (rank : 354)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	329	Target Neighborhood Hits	905	Shared Neighborhood Hits	62
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FGD6_MOUSE
NC score	0.063688 (rank : 355)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	329	Target Neighborhood Hits	282	Shared Neighborhood Hits	34
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZAP70_HUMAN
NC score	0.063628 (rank : 356)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	329	Target Neighborhood Hits	893	Shared Neighborhood Hits	62
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

WASIP_HUMAN
NC score	0.063585 (rank : 357)	θ value	3.0926 (rank : 248)
Query Neighborhood Hits	329	Target Neighborhood Hits	458	Shared Neighborhood Hits	59
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

SOCS7_MOUSE
NC score	0.063566 (rank : 358)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	329	Target Neighborhood Hits	154	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

KSYK_HUMAN
NC score	0.063324 (rank : 359)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	329	Target Neighborhood Hits	901	Shared Neighborhood Hits	62
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

NRAP_MOUSE
NC score	0.063219 (rank : 360)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	329	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

RTN4_MOUSE
NC score	0.063109 (rank : 361)	θ value	0.163984 (rank : 158)
Query Neighborhood Hits	329	Target Neighborhood Hits	341	Shared Neighborhood Hits	46
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SOS1_MOUSE
NC score	0.063012 (rank : 362)	θ value	8.99809 (rank : 325)
Query Neighborhood Hits	329	Target Neighborhood Hits	281	Shared Neighborhood Hits	48
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

NRAP_HUMAN
NC score	0.063003 (rank : 363)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	329	Target Neighborhood Hits	159	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

TRIO_HUMAN
NC score	0.062971 (rank : 364)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	329	Target Neighborhood Hits	1580	Shared Neighborhood Hits	109
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PKHG4_HUMAN
NC score	0.062688 (rank : 365)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	329	Target Neighborhood Hits	200	Shared Neighborhood Hits	27
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

SOS1_HUMAN
NC score	0.062637 (rank : 366)	θ value	8.99809 (rank : 324)
Query Neighborhood Hits	329	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

OGFR_HUMAN
NC score	0.062349 (rank : 367)	θ value	1.81305 (rank : 212)
Query Neighborhood Hits	329	Target Neighborhood Hits	1582	Shared Neighborhood Hits	120
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

HSH2D_MOUSE
NC score	0.061520 (rank : 368)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	329	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MINT_MOUSE
NC score	0.061401 (rank : 369)	θ value	0.0961366 (rank : 151)
Query Neighborhood Hits	329	Target Neighborhood Hits	1514	Shared Neighborhood Hits	124
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

GSCR1_HUMAN
NC score	0.061147 (rank : 370)	θ value	5.27518 (rank : 270)
Query Neighborhood Hits	329	Target Neighborhood Hits	674	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

SAMN1_MOUSE
NC score	0.060966 (rank : 371)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	329	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

NCOA6_MOUSE
NC score	0.060847 (rank : 372)	θ value	0.813845 (rank : 184)
Query Neighborhood Hits	329	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

FARP2_HUMAN
NC score	0.060305 (rank : 373)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	329	Target Neighborhood Hits	240	Shared Neighborhood Hits	36
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SH23A_HUMAN
NC score	0.060014 (rank : 374)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	329	Target Neighborhood Hits	149	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

YLPM1_MOUSE
NC score	0.059047 (rank : 375)	θ value	4.03905 (rank : 265)
Query Neighborhood Hits	329	Target Neighborhood Hits	505	Shared Neighborhood Hits	57
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

TEX14_HUMAN
NC score	0.059010 (rank : 376)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	329	Target Neighborhood Hits	1103	Shared Neighborhood Hits	65
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

FARP1_HUMAN
NC score	0.058899 (rank : 377)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	329	Target Neighborhood Hits	241	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

OPHN1_HUMAN
NC score	0.058781 (rank : 378)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	329	Target Neighborhood Hits	161	Shared Neighborhood Hits	25
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

TEX14_MOUSE
NC score	0.057953 (rank : 379)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	329	Target Neighborhood Hits	1333	Shared Neighborhood Hits	68
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

REPS2_HUMAN
NC score	0.057782 (rank : 380)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	329	Target Neighborhood Hits	131	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

PRP2_MOUSE
NC score	0.057484 (rank : 381)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	329	Target Neighborhood Hits	347	Shared Neighborhood Hits	41
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SON_MOUSE
NC score	0.056504 (rank : 382)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	329	Target Neighborhood Hits	957	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

MPP5_HUMAN
NC score	0.056470 (rank : 383)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	329	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

REPS2_MOUSE
NC score	0.056466 (rank : 384)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	329	Target Neighborhood Hits	102	Shared Neighborhood Hits	16
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

TARSH_HUMAN
NC score	0.056431 (rank : 385)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	329	Target Neighborhood Hits	768	Shared Neighborhood Hits	95
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ACINU_HUMAN
NC score	0.056085 (rank : 386)	θ value	0.163984 (rank : 156)
Query Neighborhood Hits	329	Target Neighborhood Hits	828	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ILK_MOUSE
NC score	0.055737 (rank : 387)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	329	Target Neighborhood Hits	858	Shared Neighborhood Hits	50
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

FGD6_HUMAN
NC score	0.055730 (rank : 388)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	329	Target Neighborhood Hits	237	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

RHG25_MOUSE
NC score	0.055714 (rank : 389)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	329	Target Neighborhood Hits	492	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

MPP5_MOUSE
NC score	0.055611 (rank : 390)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PCLO_MOUSE
NC score	0.055519 (rank : 391)	θ value	2.36792 (rank : 226)
Query Neighborhood Hits	329	Target Neighborhood Hits	2275	Shared Neighborhood Hits	145
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ILK1_HUMAN
NC score	0.055462 (rank : 392)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	329	Target Neighborhood Hits	857	Shared Neighborhood Hits	50
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
NC score	0.055265 (rank : 393)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	329	Target Neighborhood Hits	848	Shared Neighborhood Hits	50
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

OPHN1_MOUSE
NC score	0.055225 (rank : 394)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	22
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

SH24A_MOUSE
NC score	0.055106 (rank : 395)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	329	Target Neighborhood Hits	326	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

MLL2_HUMAN
NC score	0.054795 (rank : 396)	θ value	5.27518 (rank : 271)
Query Neighborhood Hits	329	Target Neighborhood Hits	1788	Shared Neighborhood Hits	108
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

CS016_HUMAN
NC score	0.054641 (rank : 397)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	329	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

PRRT3_HUMAN
NC score	0.054483 (rank : 398)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	329	Target Neighborhood Hits	998	Shared Neighborhood Hits	103
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SOCS6_HUMAN
NC score	0.054001 (rank : 399)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	329	Target Neighborhood Hits	126	Shared Neighborhood Hits	33
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.053899 (rank : 400)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	329	Target Neighborhood Hits	146	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

DOCK4_MOUSE
NC score	0.053790 (rank : 401)	θ value	3.0926 (rank : 236)
Query Neighborhood Hits	329	Target Neighborhood Hits	210	Shared Neighborhood Hits	46
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

RGS3_HUMAN
NC score	0.053762 (rank : 402)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	329	Target Neighborhood Hits	1375	Shared Neighborhood Hits	108
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

MYO9B_HUMAN
NC score	0.053642 (rank : 403)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	329	Target Neighborhood Hits	641	Shared Neighborhood Hits	70
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

WASL_MOUSE
NC score	0.053523 (rank : 404)	θ value	1.38821 (rank : 204)
Query Neighborhood Hits	329	Target Neighborhood Hits	339	Shared Neighborhood Hits	43
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASIP_MOUSE
NC score	0.053267 (rank : 405)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	329	Target Neighborhood Hits	392	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

FES_HUMAN
NC score	0.053176 (rank : 406)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	329	Target Neighborhood Hits	978	Shared Neighborhood Hits	59
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MUC7_HUMAN
NC score	0.053067 (rank : 407)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	329	Target Neighborhood Hits	538	Shared Neighborhood Hits	55
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

HGS_MOUSE
NC score	0.052411 (rank : 408)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	329	Target Neighborhood Hits	589	Shared Neighborhood Hits	54
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

WASL_HUMAN
NC score	0.052136 (rank : 409)	θ value	0.62314 (rank : 180)
Query Neighborhood Hits	329	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ERBB4_HUMAN
NC score	0.052124 (rank : 410)	θ value	0.0431538 (rank : 132)
Query Neighborhood Hits	329	Target Neighborhood Hits	910	Shared Neighborhood Hits	44
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

TXND2_HUMAN
NC score	0.052040 (rank : 411)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	329	Target Neighborhood Hits	793	Shared Neighborhood Hits	83
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

ACINU_MOUSE
NC score	0.051746 (rank : 412)	θ value	3.0926 (rank : 232)
Query Neighborhood Hits	329	Target Neighborhood Hits	712	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ECM1_MOUSE
NC score	0.051647 (rank : 413)	θ value	0.279714 (rank : 161)
Query Neighborhood Hits	329	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

SRRM1_MOUSE
NC score	0.051628 (rank : 414)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	329	Target Neighborhood Hits	966	Shared Neighborhood Hits	93
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

ENAH_MOUSE
NC score	0.051566 (rank : 415)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	329	Target Neighborhood Hits	919	Shared Neighborhood Hits	73
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

BSN_MOUSE
NC score	0.051275 (rank : 416)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	329	Target Neighborhood Hits	2057	Shared Neighborhood Hits	132
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SOCS2_MOUSE
NC score	0.051142 (rank : 417)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	329	Target Neighborhood Hits	94	Shared Neighborhood Hits	31
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

TROAP_HUMAN
NC score	0.051090 (rank : 418)	θ value	1.06291 (rank : 191)
Query Neighborhood Hits	329	Target Neighborhood Hits	258	Shared Neighborhood Hits	35
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

DGCR8_HUMAN
NC score	0.050996 (rank : 419)	θ value	0.0961366 (rank : 148)
Query Neighborhood Hits	329	Target Neighborhood Hits	72	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

TAF4_HUMAN
NC score	0.050961 (rank : 420)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	329	Target Neighborhood Hits	687	Shared Neighborhood Hits	64
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

WNK2_HUMAN
NC score	0.050956 (rank : 421)	θ value	0.00390308 (rank : 107)
Query Neighborhood Hits	329	Target Neighborhood Hits	1407	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

MNT_MOUSE
NC score	0.050899 (rank : 422)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	329	Target Neighborhood Hits	432	Shared Neighborhood Hits	50
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MAGE1_HUMAN
NC score	0.050799 (rank : 423)	θ value	6.88961 (rank : 294)
Query Neighborhood Hits	329	Target Neighborhood Hits	1389	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CJ078_MOUSE
NC score	0.050535 (rank : 424)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	329	Target Neighborhood Hits	559	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

TNK1_MOUSE
NC score	0.050471 (rank : 425)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	329	Target Neighborhood Hits	806	Shared Neighborhood Hits	48
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

AATK_MOUSE
NC score	0.050394 (rank : 426)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	329	Target Neighborhood Hits	942	Shared Neighborhood Hits	63
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

TNK1_HUMAN
NC score	0.050313 (rank : 427)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	329	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

YLPM1_HUMAN
NC score	0.050222 (rank : 428)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	329	Target Neighborhood Hits	670	Shared Neighborhood Hits	63
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

SRRM2_HUMAN
NC score	0.050129 (rank : 429)	θ value	8.99809 (rank : 326)
Query Neighborhood Hits	329	Target Neighborhood Hits	1296	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CCNK_MOUSE
NC score	0.049975 (rank : 430)	θ value	2.36792 (rank : 219)
Query Neighborhood Hits	329	Target Neighborhood Hits	350	Shared Neighborhood Hits	46
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

SRRM1_HUMAN
NC score	0.049516 (rank : 431)	θ value	4.03905 (rank : 261)
Query Neighborhood Hits	329	Target Neighborhood Hits	690	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

MLL3_HUMAN
NC score	0.048388 (rank : 432)	θ value	1.38821 (rank : 198)
Query Neighborhood Hits	329	Target Neighborhood Hits	1644	Shared Neighborhood Hits	119
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

K0310_HUMAN
NC score	0.046972 (rank : 433)	θ value	1.81305 (rank : 208)
Query Neighborhood Hits	329	Target Neighborhood Hits	420	Shared Neighborhood Hits	49
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MAVS_HUMAN
NC score	0.046915 (rank : 434)	θ value	1.81305 (rank : 210)
Query Neighborhood Hits	329	Target Neighborhood Hits	271	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MLL4_HUMAN
NC score	0.046731 (rank : 435)	θ value	4.03905 (rank : 253)
Query Neighborhood Hits	329	Target Neighborhood Hits	722	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

GGN_HUMAN
NC score	0.046524 (rank : 436)	θ value	3.0926 (rank : 238)
Query Neighborhood Hits	329	Target Neighborhood Hits	269	Shared Neighborhood Hits	38
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

RTN4_HUMAN
NC score	0.046266 (rank : 437)	θ value	2.36792 (rank : 228)
Query Neighborhood Hits	329	Target Neighborhood Hits	357	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

NFH_MOUSE
NC score	0.045497 (rank : 438)	θ value	0.00665767 (rank : 114)
Query Neighborhood Hits	329	Target Neighborhood Hits	2247	Shared Neighborhood Hits	132
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DLG5_HUMAN
NC score	0.045310 (rank : 439)	θ value	0.0431538 (rank : 131)
Query Neighborhood Hits	329	Target Neighborhood Hits	1088	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

CBP_MOUSE
NC score	0.044748 (rank : 440)	θ value	5.27518 (rank : 268)
Query Neighborhood Hits	329	Target Neighborhood Hits	1051	Shared Neighborhood Hits	96
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

OGFR_MOUSE
NC score	0.044720 (rank : 441)	θ value	0.365318 (rank : 167)
Query Neighborhood Hits	329	Target Neighborhood Hits	584	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

KSR1_HUMAN
NC score	0.044066 (rank : 442)	θ value	3.0926 (rank : 239)
Query Neighborhood Hits	329	Target Neighborhood Hits	867	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ATN1_HUMAN
NC score	0.043622 (rank : 443)	θ value	6.88961 (rank : 281)
Query Neighborhood Hits	329	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

MAP1A_HUMAN
NC score	0.043182 (rank : 444)	θ value	3.0926 (rank : 241)
Query Neighborhood Hits	329	Target Neighborhood Hits	1626	Shared Neighborhood Hits	101
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CBP_HUMAN
NC score	0.042678 (rank : 445)	θ value	4.03905 (rank : 251)
Query Neighborhood Hits	329	Target Neighborhood Hits	941	Shared Neighborhood Hits	83
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

PCQAP_MOUSE
NC score	0.042394 (rank : 446)	θ value	8.99809 (rank : 320)
Query Neighborhood Hits	329	Target Neighborhood Hits	506	Shared Neighborhood Hits	44
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

S23IP_MOUSE
NC score	0.041790 (rank : 447)	θ value	1.38821 (rank : 201)
Query Neighborhood Hits	329	Target Neighborhood Hits	363	Shared Neighborhood Hits	60
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

TACC2_HUMAN
NC score	0.041719 (rank : 448)	θ value	6.88961 (rank : 304)
Query Neighborhood Hits	329	Target Neighborhood Hits	856	Shared Neighborhood Hits	74
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

ANR11_HUMAN
NC score	0.041507 (rank : 449)	θ value	4.03905 (rank : 249)
Query Neighborhood Hits	329	Target Neighborhood Hits	1289	Shared Neighborhood Hits	96
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

CJ012_HUMAN
NC score	0.040615 (rank : 450)	θ value	4.03905 (rank : 252)
Query Neighborhood Hits	329	Target Neighborhood Hits	467	Shared Neighborhood Hits	48
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

FMNL_MOUSE
NC score	0.040594 (rank : 451)	θ value	0.47712 (rank : 170)
Query Neighborhood Hits	329	Target Neighborhood Hits	428	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

GGA1_HUMAN
NC score	0.040503 (rank : 452)	θ value	1.38821 (rank : 197)
Query Neighborhood Hits	329	Target Neighborhood Hits	169	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

AMELX_HUMAN
NC score	0.039926 (rank : 453)	θ value	0.813845 (rank : 181)
Query Neighborhood Hits	329	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

BRD4_MOUSE
NC score	0.039216 (rank : 454)	θ value	8.99809 (rank : 309)
Query Neighborhood Hits	329	Target Neighborhood Hits	845	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

PRB4S_HUMAN
NC score	0.038645 (rank : 455)	θ value	8.99809 (rank : 322)
Query Neighborhood Hits	329	Target Neighborhood Hits	330	Shared Neighborhood Hits	41
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

BRD4_HUMAN
NC score	0.038415 (rank : 456)	θ value	8.99809 (rank : 308)
Query Neighborhood Hits	329	Target Neighborhood Hits	851	Shared Neighborhood Hits	84
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CNTRB_MOUSE
NC score	0.038351 (rank : 457)	θ value	1.38821 (rank : 194)
Query Neighborhood Hits	329	Target Neighborhood Hits	1029	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

ZAN_HUMAN
NC score	0.038303 (rank : 458)	θ value	0.0431538 (rank : 135)
Query Neighborhood Hits	329	Target Neighborhood Hits	679	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

PRR8_HUMAN
NC score	0.037779 (rank : 459)	θ value	5.27518 (rank : 275)
Query Neighborhood Hits	329	Target Neighborhood Hits	217	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

IZUM1_MOUSE
NC score	0.037413 (rank : 460)	θ value	0.365318 (rank : 165)
Query Neighborhood Hits	329	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9J7	Gene names	Izumo1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

TACC2_MOUSE
NC score	0.036953 (rank : 461)	θ value	4.03905 (rank : 262)
Query Neighborhood Hits	329	Target Neighborhood Hits	774	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

SEPT9_HUMAN
NC score	0.036723 (rank : 462)	θ value	0.62314 (rank : 179)
Query Neighborhood Hits	329	Target Neighborhood Hits	706	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

BPTF_HUMAN
NC score	0.035309 (rank : 463)	θ value	4.03905 (rank : 250)
Query Neighborhood Hits	329	Target Neighborhood Hits	786	Shared Neighborhood Hits	60
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BAT3_HUMAN
NC score	0.034862 (rank : 464)	θ value	8.99809 (rank : 307)
Query Neighborhood Hits	329	Target Neighborhood Hits	490	Shared Neighborhood Hits	54
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

TAU_HUMAN
NC score	0.033756 (rank : 465)	θ value	1.81305 (rank : 215)
Query Neighborhood Hits	329	Target Neighborhood Hits	448	Shared Neighborhood Hits	47
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

GOGA4_HUMAN
NC score	0.033746 (rank : 466)	θ value	1.81305 (rank : 207)
Query Neighborhood Hits	329	Target Neighborhood Hits	2034	Shared Neighborhood Hits	82
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

DOK2_MOUSE
NC score	0.033527 (rank : 467)	θ value	0.62314 (rank : 178)
Query Neighborhood Hits	329	Target Neighborhood Hits	244	Shared Neighborhood Hits	40
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

AMELY_HUMAN
NC score	0.033315 (rank : 468)	θ value	3.0926 (rank : 234)
Query Neighborhood Hits	329	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

CIC_MOUSE
NC score	0.033071 (rank : 469)	θ value	1.81305 (rank : 205)
Query Neighborhood Hits	329	Target Neighborhood Hits	742	Shared Neighborhood Hits	73
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

ENAM_HUMAN
NC score	0.033006 (rank : 470)	θ value	1.38821 (rank : 195)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

DNJC8_MOUSE
NC score	0.032042 (rank : 471)	θ value	6.88961 (rank : 288)
Query Neighborhood Hits	329	Target Neighborhood Hits	392	Shared Neighborhood Hits	22
SwissProt Accessions	Q6NZB0, Q6PG72, Q8C2M6	Gene names	Dnajc8
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 8.

TB182_HUMAN
NC score	0.031124 (rank : 472)	θ value	4.03905 (rank : 263)
Query Neighborhood Hits	329	Target Neighborhood Hits	414	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

DNJC8_HUMAN
NC score	0.030376 (rank : 473)	θ value	6.88961 (rank : 287)
Query Neighborhood Hits	329	Target Neighborhood Hits	380	Shared Neighborhood Hits	20
SwissProt Accessions	O75937, Q6IBA4, Q8N4Z5, Q9P051, Q9P067	Gene names	DNAJC8, SPF31
Domain Architecture
Description	DnaJ homolog subfamily C member 8 (Splicing protein spf31).

TACC3_MOUSE
NC score	0.029372 (rank : 474)	θ value	0.813845 (rank : 187)
Query Neighborhood Hits	329	Target Neighborhood Hits	607	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

CUTL2_MOUSE
NC score	0.028225 (rank : 475)	θ value	0.21417 (rank : 160)
Query Neighborhood Hits	329	Target Neighborhood Hits	771	Shared Neighborhood Hits	41
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

AIM1_HUMAN
NC score	0.027569 (rank : 476)	θ value	3.0926 (rank : 233)
Query Neighborhood Hits	329	Target Neighborhood Hits	247	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

PKHA4_HUMAN
NC score	0.027525 (rank : 477)	θ value	1.38821 (rank : 200)
Query Neighborhood Hits	329	Target Neighborhood Hits	283	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SN1L2_HUMAN
NC score	0.027282 (rank : 478)	θ value	2.36792 (rank : 229)
Query Neighborhood Hits	329	Target Neighborhood Hits	964	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MYST3_HUMAN
NC score	0.026951 (rank : 479)	θ value	1.38821 (rank : 199)
Query Neighborhood Hits	329	Target Neighborhood Hits	772	Shared Neighborhood Hits	56
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

SPEG_HUMAN
NC score	0.026889 (rank : 480)	θ value	1.06291 (rank : 190)
Query Neighborhood Hits	329	Target Neighborhood Hits	1762	Shared Neighborhood Hits	107
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PTN23_HUMAN
NC score	0.026825 (rank : 481)	θ value	3.0926 (rank : 246)
Query Neighborhood Hits	329	Target Neighborhood Hits	646	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

EP400_MOUSE
NC score	0.026779 (rank : 482)	θ value	1.38821 (rank : 196)
Query Neighborhood Hits	329	Target Neighborhood Hits	592	Shared Neighborhood Hits	60
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

PTN23_MOUSE
NC score	0.026129 (rank : 483)	θ value	4.03905 (rank : 258)
Query Neighborhood Hits	329	Target Neighborhood Hits	726	Shared Neighborhood Hits	68
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SN1L2_MOUSE
NC score	0.026114 (rank : 484)	θ value	5.27518 (rank : 277)
Query Neighborhood Hits	329	Target Neighborhood Hits	944	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

TXLNB_HUMAN
NC score	0.025461 (rank : 485)	θ value	0.47712 (rank : 172)
Query Neighborhood Hits	329	Target Neighborhood Hits	912	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

SNIP_HUMAN
NC score	0.025333 (rank : 486)	θ value	6.88961 (rank : 303)
Query Neighborhood Hits	329	Target Neighborhood Hits	313	Shared Neighborhood Hits	27
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

DAB2_MOUSE
NC score	0.024287 (rank : 487)	θ value	1.81305 (rank : 206)
Query Neighborhood Hits	329	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

E2AK3_MOUSE
NC score	0.024064 (rank : 488)	θ value	3.0926 (rank : 237)
Query Neighborhood Hits	329	Target Neighborhood Hits	851	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

SV2B_MOUSE
NC score	0.023576 (rank : 489)	θ value	1.38821 (rank : 202)
Query Neighborhood Hits	329	Target Neighborhood Hits	75	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG39, Q80TT1, Q9ES95	Gene names	Sv2b, Kiaa0735
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2B (Synaptic vesicle protein 2B).

RPGF1_HUMAN
NC score	0.023418 (rank : 490)	θ value	8.99809 (rank : 323)
Query Neighborhood Hits	329	Target Neighborhood Hits	262	Shared Neighborhood Hits	45
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

PAG1_HUMAN
NC score	0.023292 (rank : 491)	θ value	3.0926 (rank : 243)
Query Neighborhood Hits	329	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NWQ8, Q2M1Z9, Q5BKU4, Q9NYK0	Gene names	PAG1, CBP, PAG
Domain Architecture	No domain graphic available
Description	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Transmembrane adapter protein PAG) (Csk-binding protein) (Transmembrane phosphoprotein Cbp).

TITIN_HUMAN
NC score	0.023053 (rank : 492)	θ value	1.38821 (rank : 203)
Query Neighborhood Hits	329	Target Neighborhood Hits	2923	Shared Neighborhood Hits	131
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NASP_HUMAN
NC score	0.022816 (rank : 493)	θ value	5.27518 (rank : 272)
Query Neighborhood Hits	329	Target Neighborhood Hits	709	Shared Neighborhood Hits	39
SwissProt Accessions	P49321, Q96A69, Q9BTW2	Gene names	NASP
Domain Architecture
Description	Nuclear autoantigenic sperm protein (NASP).

LARP4_MOUSE
NC score	0.022396 (rank : 494)	θ value	8.99809 (rank : 315)
Query Neighborhood Hits	329	Target Neighborhood Hits	260	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

PKN1_HUMAN
NC score	0.021195 (rank : 495)	θ value	8.99809 (rank : 321)
Query Neighborhood Hits	329	Target Neighborhood Hits	886	Shared Neighborhood Hits	42
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PTN22_MOUSE
NC score	0.020384 (rank : 496)	θ value	3.0926 (rank : 245)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	24
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

ZO2_MOUSE
NC score	0.018337 (rank : 497)	θ value	8.99809 (rank : 329)
Query Neighborhood Hits	329	Target Neighborhood Hits	296	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

UB7I1_HUMAN
NC score	0.017926 (rank : 498)	θ value	2.36792 (rank : 231)
Query Neighborhood Hits	329	Target Neighborhood Hits	177	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

CGRE1_HUMAN
NC score	0.017525 (rank : 499)	θ value	6.88961 (rank : 283)
Query Neighborhood Hits	329	Target Neighborhood Hits	354	Shared Neighborhood Hits	24
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

BPL1_HUMAN
NC score	0.017390 (rank : 500)	θ value	6.88961 (rank : 282)
Query Neighborhood Hits	329	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P50747, Q99451	Gene names	HLCS
Domain Architecture
Description	Biotin--protein ligase (EC 6.3.4.-) (Biotin apo-protein ligase) [Includes: Biotin--[methylmalonyl-CoA-carboxytransferase] ligase (EC 6.3.4.9); Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase (EC 6.3.4.10) (Holocarboxylase synthetase) (HCS); Biotin-- [methylcrotonoyl-CoA-carboxylase] ligase (EC 6.3.4.11); Biotin-- [acetyl-CoA-carboxylase] ligase (EC 6.3.4.15)].

ZO2_HUMAN
NC score	0.017381 (rank : 501)	θ value	1.81305 (rank : 217)
Query Neighborhood Hits	329	Target Neighborhood Hits	289	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ANK3_HUMAN
NC score	0.017285 (rank : 502)	θ value	6.88961 (rank : 280)
Query Neighborhood Hits	329	Target Neighborhood Hits	853	Shared Neighborhood Hits	54
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

MAGC1_HUMAN
NC score	0.016352 (rank : 503)	θ value	8.99809 (rank : 318)
Query Neighborhood Hits	329	Target Neighborhood Hits	431	Shared Neighborhood Hits	49
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

NPHP4_MOUSE
NC score	0.015929 (rank : 504)	θ value	4.03905 (rank : 254)
Query Neighborhood Hits	329	Target Neighborhood Hits	62	Shared Neighborhood Hits	5
SwissProt Accessions	P59240	Gene names	Nphp4
Domain Architecture	No domain graphic available
Description	Nephrocystin-4 (Nephroretinin).

NBN_HUMAN
NC score	0.015639 (rank : 505)	θ value	6.88961 (rank : 297)
Query Neighborhood Hits	329	Target Neighborhood Hits	226	Shared Neighborhood Hits	20
SwissProt Accessions	O60934, O60672, Q32NF7, Q53FM6, Q63HR6, Q7LDM2	Gene names	NBN, NBS, NBS1, P95
Domain Architecture	No domain graphic available
Description	Nibrin (Nijmegen breakage syndrome protein 1) (Cell cycle regulatory protein p95).

ZN541_HUMAN
NC score	0.014742 (rank : 506)	θ value	5.27518 (rank : 278)
Query Neighborhood Hits	329	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

PTN22_HUMAN
NC score	0.014088 (rank : 507)	θ value	4.03905 (rank : 257)
Query Neighborhood Hits	329	Target Neighborhood Hits	109	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

FILA_HUMAN
NC score	0.013867 (rank : 508)	θ value	2.36792 (rank : 220)
Query Neighborhood Hits	329	Target Neighborhood Hits	685	Shared Neighborhood Hits	18
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

TNNT1_MOUSE
NC score	0.013649 (rank : 509)	θ value	8.99809 (rank : 328)
Query Neighborhood Hits	329	Target Neighborhood Hits	212	Shared Neighborhood Hits	11
SwissProt Accessions	O88346, O88795, Q9QUP7	Gene names	Tnnt1
Domain Architecture	No domain graphic available
Description	Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT).

SYTL1_HUMAN
NC score	0.012625 (rank : 510)	θ value	3.0926 (rank : 247)
Query Neighborhood Hits	329	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

OXRP_HUMAN
NC score	0.012350 (rank : 511)	θ value	4.03905 (rank : 255)
Query Neighborhood Hits	329	Target Neighborhood Hits	544	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

NKTR_MOUSE
NC score	0.012085 (rank : 512)	θ value	2.36792 (rank : 225)
Query Neighborhood Hits	329	Target Neighborhood Hits	417	Shared Neighborhood Hits	26
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

GP152_MOUSE
NC score	0.011850 (rank : 513)	θ value	2.36792 (rank : 221)
Query Neighborhood Hits	329	Target Neighborhood Hits	607	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BXS7	Gene names	Gpr152
Domain Architecture
Description	Probable G-protein coupled receptor 152.

NEIL1_HUMAN
NC score	0.011824 (rank : 514)	θ value	6.88961 (rank : 298)
Query Neighborhood Hits	329	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q96FI4, Q6ZRA7, Q86XW7, Q9H6C3	Gene names	NEIL1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1) (FPG1).

RT18B_HUMAN
NC score	0.011708 (rank : 515)	θ value	6.88961 (rank : 302)
Query Neighborhood Hits	329	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y676, Q9BS27	Gene names	MRPS18B
Domain Architecture
Description	28S ribosomal protein S18b, mitochondrial precursor (MRP-S18-b) (Mrps18b) (MRP-S18-2).

PRDM2_HUMAN
NC score	0.011540 (rank : 516)	θ value	5.27518 (rank : 274)
Query Neighborhood Hits	329	Target Neighborhood Hits	1135	Shared Neighborhood Hits	56
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

FUS_MOUSE
NC score	0.011450 (rank : 517)	θ value	6.88961 (rank : 290)
Query Neighborhood Hits	329	Target Neighborhood Hits	154	Shared Neighborhood Hits	7
SwissProt Accessions	P56959	Gene names	Fus
Domain Architecture
Description	RNA-binding protein FUS (Pigpen protein).

FUS_HUMAN
NC score	0.011365 (rank : 518)	θ value	6.88961 (rank : 289)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	P35637	Gene names	FUS, TLS
Domain Architecture
Description	RNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated in liposarcoma protein) (POMp75) (75 kDa DNA-pairing protein).

RBM28_MOUSE
NC score	0.011036 (rank : 519)	θ value	1.81305 (rank : 214)
Query Neighborhood Hits	329	Target Neighborhood Hits	368	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CGC6, Q8BG25, Q8VEJ8, Q9CS22, Q9CSE6	Gene names	Rbm28
Domain Architecture	No domain graphic available
Description	RNA-binding protein 28 (RNA-binding motif protein 28).

PTN12_MOUSE
NC score	0.010500 (rank : 520)	θ value	1.81305 (rank : 213)
Query Neighborhood Hits	329	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P35831	Gene names	Ptpn12
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST).

SREC2_HUMAN
NC score	0.010481 (rank : 521)	θ value	4.03905 (rank : 260)
Query Neighborhood Hits	329	Target Neighborhood Hits	645	Shared Neighborhood Hits	34
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

CTNB1_MOUSE
NC score	0.009912 (rank : 522)	θ value	6.88961 (rank : 286)
Query Neighborhood Hits	329	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q02248, Q922W1, Q9D335	Gene names	Ctnnb1, Catnb
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

CTNB1_HUMAN
NC score	0.009905 (rank : 523)	θ value	6.88961 (rank : 285)
Query Neighborhood Hits	329	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	P35222, Q8NEW9, Q8NI94, Q9H391	Gene names	CTNNB1, CTNNB
Domain Architecture
Description	Catenin beta-1 (Beta-catenin).

MS3L1_HUMAN
NC score	0.009884 (rank : 524)	θ value	6.88961 (rank : 296)
Query Neighborhood Hits	329	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N5Y2, Q9UG70, Q9Y5Z8	Gene names	MSL3L1
Domain Architecture
Description	Male-specific lethal 3-like 1 (MSL3-like 1) (Male-specific lethal-3 homolog 1).

KNG1_HUMAN
NC score	0.009846 (rank : 525)	θ value	6.88961 (rank : 293)
Query Neighborhood Hits	329	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	P01042, P01043	Gene names	KNG1, BDK, KNG
Domain Architecture
Description	Kininogen-1 precursor (Alpha-2-thiol proteinase inhibitor) [Contains: Kininogen-1 heavy chain; Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth- promoting factor].

MAGB6_HUMAN
NC score	0.009291 (rank : 526)	θ value	3.0926 (rank : 240)
Query Neighborhood Hits	329	Target Neighborhood Hits	184	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MOR2B_MOUSE
NC score	0.008103 (rank : 527)	θ value	6.88961 (rank : 295)
Query Neighborhood Hits	329	Target Neighborhood Hits	91	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C5W4, Q8CG24	Gene names	Morc2b, Tce6
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 2B (TCE6).

KI21A_MOUSE
NC score	0.008064 (rank : 528)	θ value	6.88961 (rank : 292)
Query Neighborhood Hits	329	Target Neighborhood Hits	1317	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

TRI37_HUMAN
NC score	0.005494 (rank : 529)	θ value	4.03905 (rank : 264)
Query Neighborhood Hits	329	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

CLCN1_MOUSE
NC score	0.005468 (rank : 530)	θ value	6.88961 (rank : 284)
Query Neighborhood Hits	329	Target Neighborhood Hits	61	Shared Neighborhood Hits	12
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

NOS3_HUMAN
NC score	0.005461 (rank : 531)	θ value	6.88961 (rank : 299)
Query Neighborhood Hits	329	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P29474, Q13662, Q14251, Q14434	Gene names	NOS3
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

JPH3_HUMAN
NC score	0.005230 (rank : 532)	θ value	6.88961 (rank : 291)
Query Neighborhood Hits	329	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

HXA3_HUMAN
NC score	0.004540 (rank : 533)	θ value	8.99809 (rank : 313)
Query Neighborhood Hits	329	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

PCD15_HUMAN
NC score	0.002177 (rank : 534)	θ value	8.99809 (rank : 319)
Query Neighborhood Hits	329	Target Neighborhood Hits	289	Shared Neighborhood Hits	19
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

ROA0_HUMAN
NC score	0.002137 (rank : 535)	θ value	6.88961 (rank : 301)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	4
SwissProt Accessions	Q13151	Gene names	HNRPA0
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0).

KCNH3_MOUSE
NC score	0.001873 (rank : 536)	θ value	8.99809 (rank : 314)
Query Neighborhood Hits	329	Target Neighborhood Hits	133	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KLK1_MOUSE
NC score	-0.001784 (rank : 537)	θ value	2.36792 (rank : 222)
Query Neighborhood Hits	329	Target Neighborhood Hits	179	Shared Neighborhood Hits	2
SwissProt Accessions	P15947, Q61855	Gene names	Klk1, Klk-6, Klk6
Domain Architecture
Description	Glandular kallikrein K1 precursor (EC 3.4.21.35) (Tissue kallikrein-6) (mGK-6) (Renal kallikrein) (KAL-B).

DSG2_MOUSE
NC score	-0.002113 (rank : 538)	θ value	8.99809 (rank : 310)
Query Neighborhood Hits	329	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	O55111, Q8K069, Q8R517	Gene names	Dsg2
Domain Architecture
Description	Desmoglein-2 precursor.

ZN688_HUMAN
NC score	-0.006383 (rank : 539)	θ value	1.81305 (rank : 216)
Query Neighborhood Hits	329	Target Neighborhood Hits	873	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WV14, O75701, Q8IW91, Q96MN0	Gene names	ZNF688
Domain Architecture	No domain graphic available
Description	Zinc finger protein 688.

ZN287_MOUSE
NC score	-0.009202 (rank : 540)	θ value	4.03905 (rank : 266)
Query Neighborhood Hits	329	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQB9	Gene names	Znf287, Skat2, Zfp287
Domain Architecture
Description	Zinc finger protein 287 (Zfp-287) (Zinc finger protein SKAT-2).