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Network neighborhood for query Sequence : RUSC1_HUMAN

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RUSC1_HUMAN
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RUSC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	226	Target Neighborhood Hits	226	Shared Neighborhood Hits	226
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	0 (rank : 2)	NC score	0.957171 (rank : 2)
Query Neighborhood Hits	226	Target Neighborhood Hits	206	Shared Neighborhood Hits	138
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_MOUSE
θ value	6.13105e-57 (rank : 3)	NC score	0.686593 (rank : 4)
Query Neighborhood Hits	226	Target Neighborhood Hits	305	Shared Neighborhood Hits	64
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_HUMAN
θ value	3.0428e-56 (rank : 4)	NC score	0.711900 (rank : 3)
Query Neighborhood Hits	226	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ITSN1_MOUSE
θ value	2.21117e-06 (rank : 5)	NC score	0.242128 (rank : 83)
Query Neighborhood Hits	226	Target Neighborhood Hits	1669	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
θ value	8.40245e-06 (rank : 6)	NC score	0.241209 (rank : 85)
Query Neighborhood Hits	226	Target Neighborhood Hits	1757	Shared Neighborhood Hits	156
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

EFS_HUMAN
θ value	5.44631e-05 (rank : 7)	NC score	0.368350 (rank : 8)
Query Neighborhood Hits	226	Target Neighborhood Hits	348	Shared Neighborhood Hits	131
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	5.44631e-05 (rank : 8)	NC score	0.371007 (rank : 6)
Query Neighborhood Hits	226	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RHG04_HUMAN
θ value	7.1131e-05 (rank : 9)	NC score	0.243635 (rank : 82)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	120
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ABI2_MOUSE
θ value	9.29e-05 (rank : 10)	NC score	0.364890 (rank : 10)
Query Neighborhood Hits	226	Target Neighborhood Hits	266	Shared Neighborhood Hits	134
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BTK_HUMAN
θ value	9.29e-05 (rank : 11)	NC score	0.099646 (rank : 162)
Query Neighborhood Hits	226	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	0.00020696 (rank : 12)	NC score	0.096572 (rank : 164)
Query Neighborhood Hits	226	Target Neighborhood Hits	1017	Shared Neighborhood Hits	120
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

PPIP1_HUMAN
θ value	0.00020696 (rank : 13)	NC score	0.370952 (rank : 7)
Query Neighborhood Hits	226	Target Neighborhood Hits	389	Shared Neighborhood Hits	140
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ABI2_HUMAN
θ value	0.00035302 (rank : 14)	NC score	0.364970 (rank : 9)
Query Neighborhood Hits	226	Target Neighborhood Hits	350	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

NSD1_MOUSE
θ value	0.000786445 (rank : 15)	NC score	0.063576 (rank : 223)
Query Neighborhood Hits	226	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PPIP1_MOUSE
θ value	0.000786445 (rank : 16)	NC score	0.348106 (rank : 12)
Query Neighborhood Hits	226	Target Neighborhood Hits	377	Shared Neighborhood Hits	138
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SHLB2_MOUSE
θ value	0.000786445 (rank : 17)	NC score	0.253809 (rank : 70)
Query Neighborhood Hits	226	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

CRKL_HUMAN
θ value	0.00102713 (rank : 18)	NC score	0.315535 (rank : 32)
Query Neighborhood Hits	226	Target Neighborhood Hits	313	Shared Neighborhood Hits	136
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

SHLB2_HUMAN
θ value	0.00134147 (rank : 19)	NC score	0.251153 (rank : 74)
Query Neighborhood Hits	226	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

AHI1_MOUSE
θ value	0.00175202 (rank : 20)	NC score	0.257293 (rank : 69)
Query Neighborhood Hits	226	Target Neighborhood Hits	496	Shared Neighborhood Hits	136
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CRKL_MOUSE
θ value	0.00175202 (rank : 21)	NC score	0.308627 (rank : 35)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	135
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITSN2_MOUSE
θ value	0.00228821 (rank : 22)	NC score	0.234015 (rank : 86)
Query Neighborhood Hits	226	Target Neighborhood Hits	1371	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PACN3_MOUSE
θ value	0.00298849 (rank : 23)	NC score	0.293193 (rank : 47)
Query Neighborhood Hits	226	Target Neighborhood Hits	380	Shared Neighborhood Hits	123
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

BCAR1_HUMAN
θ value	0.00390308 (rank : 24)	NC score	0.295475 (rank : 45)
Query Neighborhood Hits	226	Target Neighborhood Hits	554	Shared Neighborhood Hits	144
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	0.00390308 (rank : 25)	NC score	0.305968 (rank : 37)
Query Neighborhood Hits	226	Target Neighborhood Hits	438	Shared Neighborhood Hits	139
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SPTA1_HUMAN
θ value	0.00509761 (rank : 26)	NC score	0.155550 (rank : 121)
Query Neighborhood Hits	226	Target Neighborhood Hits	748	Shared Neighborhood Hits	129
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

AHI1_HUMAN
θ value	0.00665767 (rank : 27)	NC score	0.244672 (rank : 81)
Query Neighborhood Hits	226	Target Neighborhood Hits	537	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ITSN2_HUMAN
θ value	0.00665767 (rank : 28)	NC score	0.246942 (rank : 78)
Query Neighborhood Hits	226	Target Neighborhood Hits	1173	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PACN3_HUMAN
θ value	0.00665767 (rank : 29)	NC score	0.283481 (rank : 57)
Query Neighborhood Hits	226	Target Neighborhood Hits	385	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

VINEX_MOUSE
θ value	0.00665767 (rank : 30)	NC score	0.348175 (rank : 11)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

GRB2_HUMAN
θ value	0.00869519 (rank : 31)	NC score	0.320795 (rank : 23)
Query Neighborhood Hits	226	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00869519 (rank : 32)	NC score	0.320356 (rank : 24)
Query Neighborhood Hits	226	Target Neighborhood Hits	312	Shared Neighborhood Hits	138
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF2_HUMAN
θ value	0.00869519 (rank : 33)	NC score	0.386802 (rank : 5)
Query Neighborhood Hits	226	Target Neighborhood Hits	229	Shared Neighborhood Hits	124
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NEBU_HUMAN
θ value	0.00869519 (rank : 34)	NC score	0.245267 (rank : 80)
Query Neighborhood Hits	226	Target Neighborhood Hits	420	Shared Neighborhood Hits	117
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

ABI1_MOUSE
θ value	0.0113563 (rank : 35)	NC score	0.329623 (rank : 16)
Query Neighborhood Hits	226	Target Neighborhood Hits	246	Shared Neighborhood Hits	132
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

FGR_MOUSE
θ value	0.0113563 (rank : 36)	NC score	0.101825 (rank : 159)
Query Neighborhood Hits	226	Target Neighborhood Hits	1069	Shared Neighborhood Hits	132
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SHLB1_MOUSE
θ value	0.0113563 (rank : 37)	NC score	0.249085 (rank : 76)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

DBNL_HUMAN
θ value	0.0148317 (rank : 38)	NC score	0.300071 (rank : 40)
Query Neighborhood Hits	226	Target Neighborhood Hits	244	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

LASP1_HUMAN
θ value	0.0148317 (rank : 39)	NC score	0.304122 (rank : 39)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	114
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.0148317 (rank : 40)	NC score	0.296178 (rank : 44)
Query Neighborhood Hits	226	Target Neighborhood Hits	297	Shared Neighborhood Hits	113
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SHLB1_HUMAN
θ value	0.0148317 (rank : 41)	NC score	0.245789 (rank : 79)
Query Neighborhood Hits	226	Target Neighborhood Hits	96	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ABI1_HUMAN
θ value	0.0193708 (rank : 42)	NC score	0.320117 (rank : 25)
Query Neighborhood Hits	226	Target Neighborhood Hits	257	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRAP_HUMAN
θ value	0.0193708 (rank : 43)	NC score	0.315553 (rank : 31)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	139
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

IASPP_HUMAN
θ value	0.0193708 (rank : 44)	NC score	0.211465 (rank : 92)
Query Neighborhood Hits	226	Target Neighborhood Hits	688	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NCK1_HUMAN
θ value	0.0193708 (rank : 45)	NC score	0.291152 (rank : 49)
Query Neighborhood Hits	226	Target Neighborhood Hits	312	Shared Neighborhood Hits	137
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NEBL_HUMAN
θ value	0.0193708 (rank : 46)	NC score	0.263180 (rank : 67)
Query Neighborhood Hits	226	Target Neighborhood Hits	457	Shared Neighborhood Hits	117
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

FGR_HUMAN
θ value	0.0252991 (rank : 47)	NC score	0.102979 (rank : 158)
Query Neighborhood Hits	226	Target Neighborhood Hits	1067	Shared Neighborhood Hits	129
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NPHP1_MOUSE
θ value	0.0330416 (rank : 48)	NC score	0.298641 (rank : 42)
Query Neighborhood Hits	226	Target Neighborhood Hits	267	Shared Neighborhood Hits	129
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SH3G1_HUMAN
θ value	0.0330416 (rank : 49)	NC score	0.327127 (rank : 18)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	126
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

GRAP2_MOUSE
θ value	0.0431538 (rank : 50)	NC score	0.319897 (rank : 27)
Query Neighborhood Hits	226	Target Neighborhood Hits	297	Shared Neighborhood Hits	142
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

VINEX_HUMAN
θ value	0.0431538 (rank : 51)	NC score	0.335786 (rank : 14)
Query Neighborhood Hits	226	Target Neighborhood Hits	270	Shared Neighborhood Hits	136
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CD2AP_MOUSE
θ value	0.0563607 (rank : 52)	NC score	0.323353 (rank : 19)
Query Neighborhood Hits	226	Target Neighborhood Hits	336	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DBNL_MOUSE
θ value	0.0563607 (rank : 53)	NC score	0.292770 (rank : 48)
Query Neighborhood Hits	226	Target Neighborhood Hits	306	Shared Neighborhood Hits	115
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

GLI3_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.009674 (rank : 331)
Query Neighborhood Hits	226	Target Neighborhood Hits	871	Shared Neighborhood Hits	13
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

GON4L_HUMAN
θ value	0.0563607 (rank : 55)	NC score	0.048861 (rank : 268)
Query Neighborhood Hits	226	Target Neighborhood Hits	555	Shared Neighborhood Hits	22
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

IASPP_MOUSE
θ value	0.0563607 (rank : 56)	NC score	0.189303 (rank : 101)
Query Neighborhood Hits	226	Target Neighborhood Hits	1024	Shared Neighborhood Hits	147
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MATK_HUMAN
θ value	0.0563607 (rank : 57)	NC score	0.061437 (rank : 226)
Query Neighborhood Hits	226	Target Neighborhood Hits	954	Shared Neighborhood Hits	60
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SH3G1_MOUSE
θ value	0.0563607 (rank : 58)	NC score	0.319356 (rank : 28)
Query Neighborhood Hits	226	Target Neighborhood Hits	291	Shared Neighborhood Hits	130
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CASL_HUMAN
θ value	0.0736092 (rank : 59)	NC score	0.264030 (rank : 66)
Query Neighborhood Hits	226	Target Neighborhood Hits	259	Shared Neighborhood Hits	118
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	0.0736092 (rank : 60)	NC score	0.264557 (rank : 65)
Query Neighborhood Hits	226	Target Neighborhood Hits	225	Shared Neighborhood Hits	113
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

GRAP2_HUMAN
θ value	0.0736092 (rank : 61)	NC score	0.314349 (rank : 33)
Query Neighborhood Hits	226	Target Neighborhood Hits	304	Shared Neighborhood Hits	141
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_MOUSE
θ value	0.0736092 (rank : 62)	NC score	0.304761 (rank : 38)
Query Neighborhood Hits	226	Target Neighborhood Hits	309	Shared Neighborhood Hits	139
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

MYO1F_HUMAN
θ value	0.0736092 (rank : 63)	NC score	0.128983 (rank : 137)
Query Neighborhood Hits	226	Target Neighborhood Hits	275	Shared Neighborhood Hits	135
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH3G2_HUMAN
θ value	0.0736092 (rank : 64)	NC score	0.319982 (rank : 26)
Query Neighborhood Hits	226	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	0.0736092 (rank : 65)	NC score	0.328121 (rank : 17)
Query Neighborhood Hits	226	Target Neighborhood Hits	319	Shared Neighborhood Hits	134
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CRK_HUMAN
θ value	0.0961366 (rank : 66)	NC score	0.288452 (rank : 53)
Query Neighborhood Hits	226	Target Neighborhood Hits	308	Shared Neighborhood Hits	133
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0961366 (rank : 67)	NC score	0.290036 (rank : 52)
Query Neighborhood Hits	226	Target Neighborhood Hits	314	Shared Neighborhood Hits	132
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PNMT_HUMAN
θ value	0.0961366 (rank : 68)	NC score	0.059183 (rank : 232)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P11086	Gene names	PNMT, PENT
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

SRC8_HUMAN
θ value	0.0961366 (rank : 69)	NC score	0.321334 (rank : 22)
Query Neighborhood Hits	226	Target Neighborhood Hits	269	Shared Neighborhood Hits	132
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.0961366 (rank : 70)	NC score	0.319053 (rank : 29)
Query Neighborhood Hits	226	Target Neighborhood Hits	292	Shared Neighborhood Hits	133
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DNMBP_HUMAN
θ value	0.125558 (rank : 71)	NC score	0.271407 (rank : 64)
Query Neighborhood Hits	226	Target Neighborhood Hits	413	Shared Neighborhood Hits	139
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SPTA2_HUMAN
θ value	0.125558 (rank : 72)	NC score	0.151031 (rank : 125)
Query Neighborhood Hits	226	Target Neighborhood Hits	888	Shared Neighborhood Hits	133
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAT6_HUMAN
θ value	0.125558 (rank : 73)	NC score	0.029371 (rank : 294)
Query Neighborhood Hits	226	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

FRK_HUMAN
θ value	0.163984 (rank : 74)	NC score	0.084664 (rank : 177)
Query Neighborhood Hits	226	Target Neighborhood Hits	1058	Shared Neighborhood Hits	132
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

HCLS1_HUMAN
θ value	0.163984 (rank : 75)	NC score	0.340642 (rank : 13)
Query Neighborhood Hits	226	Target Neighborhood Hits	358	Shared Neighborhood Hits	138
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

NCF4_MOUSE
θ value	0.163984 (rank : 76)	NC score	0.321553 (rank : 21)
Query Neighborhood Hits	226	Target Neighborhood Hits	177	Shared Neighborhood Hits	112
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRGP2_MOUSE
θ value	0.163984 (rank : 77)	NC score	0.193047 (rank : 96)
Query Neighborhood Hits	226	Target Neighborhood Hits	324	Shared Neighborhood Hits	117
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAM1_HUMAN
θ value	0.163984 (rank : 78)	NC score	0.290469 (rank : 50)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	137
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.163984 (rank : 79)	NC score	0.290073 (rank : 51)
Query Neighborhood Hits	226	Target Neighborhood Hits	273	Shared Neighborhood Hits	137
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ZN447_HUMAN
θ value	0.163984 (rank : 80)	NC score	0.008848 (rank : 334)
Query Neighborhood Hits	226	Target Neighborhood Hits	899	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

ANM2_MOUSE
θ value	0.21417 (rank : 81)	NC score	0.190437 (rank : 99)
Query Neighborhood Hits	226	Target Neighborhood Hits	175	Shared Neighborhood Hits	112
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CD2AP_HUMAN
θ value	0.21417 (rank : 82)	NC score	0.306607 (rank : 36)
Query Neighborhood Hits	226	Target Neighborhood Hits	315	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DDEF2_HUMAN
θ value	0.21417 (rank : 83)	NC score	0.146974 (rank : 128)
Query Neighborhood Hits	226	Target Neighborhood Hits	599	Shared Neighborhood Hits	128
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.21417 (rank : 84)	NC score	0.150622 (rank : 126)
Query Neighborhood Hits	226	Target Neighborhood Hits	625	Shared Neighborhood Hits	124
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SRGP2_HUMAN
θ value	0.21417 (rank : 85)	NC score	0.189994 (rank : 100)
Query Neighborhood Hits	226	Target Neighborhood Hits	331	Shared Neighborhood Hits	115
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAM2_MOUSE
θ value	0.21417 (rank : 86)	NC score	0.297965 (rank : 43)
Query Neighborhood Hits	226	Target Neighborhood Hits	285	Shared Neighborhood Hits	139
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

YES_HUMAN
θ value	0.21417 (rank : 87)	NC score	0.100675 (rank : 161)
Query Neighborhood Hits	226	Target Neighborhood Hits	1059	Shared Neighborhood Hits	132
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	0.21417 (rank : 88)	NC score	0.100992 (rank : 160)
Query Neighborhood Hits	226	Target Neighborhood Hits	1052	Shared Neighborhood Hits	132
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DNMBP_MOUSE
θ value	0.279714 (rank : 89)	NC score	0.250729 (rank : 75)
Query Neighborhood Hits	226	Target Neighborhood Hits	435	Shared Neighborhood Hits	141
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCLS1_MOUSE
θ value	0.279714 (rank : 90)	NC score	0.331614 (rank : 15)
Query Neighborhood Hits	226	Target Neighborhood Hits	329	Shared Neighborhood Hits	140
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

K0310_HUMAN
θ value	0.279714 (rank : 91)	NC score	0.062796 (rank : 224)
Query Neighborhood Hits	226	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

MYO1F_MOUSE
θ value	0.279714 (rank : 92)	NC score	0.126811 (rank : 139)
Query Neighborhood Hits	226	Target Neighborhood Hits	262	Shared Neighborhood Hits	130
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

OSTF1_HUMAN
θ value	0.279714 (rank : 93)	NC score	0.241719 (rank : 84)
Query Neighborhood Hits	226	Target Neighborhood Hits	466	Shared Neighborhood Hits	136
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

PACN2_MOUSE
θ value	0.279714 (rank : 94)	NC score	0.283497 (rank : 56)
Query Neighborhood Hits	226	Target Neighborhood Hits	382	Shared Neighborhood Hits	128
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G3_HUMAN
θ value	0.279714 (rank : 95)	NC score	0.317434 (rank : 30)
Query Neighborhood Hits	226	Target Neighborhood Hits	222	Shared Neighborhood Hits	125
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	0.279714 (rank : 96)	NC score	0.321687 (rank : 20)
Query Neighborhood Hits	226	Target Neighborhood Hits	236	Shared Neighborhood Hits	130
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SPTA1_MOUSE
θ value	0.279714 (rank : 97)	NC score	0.141196 (rank : 129)
Query Neighborhood Hits	226	Target Neighborhood Hits	675	Shared Neighborhood Hits	121
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAM2_HUMAN
θ value	0.279714 (rank : 98)	NC score	0.276459 (rank : 61)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	133
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

MUC5B_HUMAN
θ value	0.365318 (rank : 99)	NC score	0.033364 (rank : 286)
Query Neighborhood Hits	226	Target Neighborhood Hits	1020	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NCF4_HUMAN
θ value	0.365318 (rank : 100)	NC score	0.309821 (rank : 34)
Query Neighborhood Hits	226	Target Neighborhood Hits	161	Shared Neighborhood Hits	103
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PNMT_MOUSE
θ value	0.365318 (rank : 101)	NC score	0.053961 (rank : 253)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P40935	Gene names	Pnmt
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

CT032_HUMAN
θ value	0.47712 (rank : 102)	NC score	0.273899 (rank : 62)
Query Neighborhood Hits	226	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT151_HUMAN
θ value	0.47712 (rank : 103)	NC score	0.049448 (rank : 267)
Query Neighborhood Hits	226	Target Neighborhood Hits	382	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

FYN_HUMAN
θ value	0.47712 (rank : 104)	NC score	0.103510 (rank : 157)
Query Neighborhood Hits	226	Target Neighborhood Hits	1078	Shared Neighborhood Hits	137
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.47712 (rank : 105)	NC score	0.105284 (rank : 154)
Query Neighborhood Hits	226	Target Neighborhood Hits	1073	Shared Neighborhood Hits	137
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GLIS3_MOUSE
θ value	0.47712 (rank : 106)	NC score	0.006893 (rank : 336)
Query Neighborhood Hits	226	Target Neighborhood Hits	861	Shared Neighborhood Hits	19
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

MISS_MOUSE
θ value	0.47712 (rank : 107)	NC score	0.048622 (rank : 269)
Query Neighborhood Hits	226	Target Neighborhood Hits	444	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

NPHP1_HUMAN
θ value	0.47712 (rank : 108)	NC score	0.262767 (rank : 68)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	120
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PACN1_HUMAN
θ value	0.47712 (rank : 109)	NC score	0.282193 (rank : 59)
Query Neighborhood Hits	226	Target Neighborhood Hits	320	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.47712 (rank : 110)	NC score	0.283630 (rank : 55)
Query Neighborhood Hits	226	Target Neighborhood Hits	283	Shared Neighborhood Hits	127
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	0.47712 (rank : 111)	NC score	0.282197 (rank : 58)
Query Neighborhood Hits	226	Target Neighborhood Hits	339	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG2_HUMAN
θ value	0.47712 (rank : 112)	NC score	0.174227 (rank : 111)
Query Neighborhood Hits	226	Target Neighborhood Hits	280	Shared Neighborhood Hits	117
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PRRT3_HUMAN
θ value	0.47712 (rank : 113)	NC score	0.042841 (rank : 277)
Query Neighborhood Hits	226	Target Neighborhood Hits	998	Shared Neighborhood Hits	45
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RFIP1_MOUSE
θ value	0.47712 (rank : 114)	NC score	0.060637 (rank : 227)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ARHG9_HUMAN
θ value	0.62314 (rank : 115)	NC score	0.168837 (rank : 115)
Query Neighborhood Hits	226	Target Neighborhood Hits	235	Shared Neighborhood Hits	116
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.62314 (rank : 116)	NC score	0.167849 (rank : 116)
Query Neighborhood Hits	226	Target Neighborhood Hits	234	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NRX2A_HUMAN
θ value	0.62314 (rank : 117)	NC score	0.026842 (rank : 303)
Query Neighborhood Hits	226	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.62314 (rank : 118)	NC score	0.039651 (rank : 280)
Query Neighborhood Hits	226	Target Neighborhood Hits	481	Shared Neighborhood Hits	22
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

OSTF1_MOUSE
θ value	0.62314 (rank : 119)	NC score	0.232263 (rank : 87)
Query Neighborhood Hits	226	Target Neighborhood Hits	467	Shared Neighborhood Hits	134
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RGS3_MOUSE
θ value	0.62314 (rank : 120)	NC score	0.044405 (rank : 276)
Query Neighborhood Hits	226	Target Neighborhood Hits	1621	Shared Neighborhood Hits	71
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SRC_HUMAN
θ value	0.62314 (rank : 121)	NC score	0.098522 (rank : 163)
Query Neighborhood Hits	226	Target Neighborhood Hits	1058	Shared Neighborhood Hits	136
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.62314 (rank : 122)	NC score	0.087781 (rank : 173)
Query Neighborhood Hits	226	Target Neighborhood Hits	1033	Shared Neighborhood Hits	117
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

ANM2_HUMAN
θ value	0.813845 (rank : 123)	NC score	0.191115 (rank : 97)
Query Neighborhood Hits	226	Target Neighborhood Hits	175	Shared Neighborhood Hits	114
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

BLK_HUMAN
θ value	0.813845 (rank : 124)	NC score	0.080167 (rank : 181)
Query Neighborhood Hits	226	Target Neighborhood Hits	994	Shared Neighborhood Hits	101
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	0.813845 (rank : 125)	NC score	0.079420 (rank : 183)
Query Neighborhood Hits	226	Target Neighborhood Hits	992	Shared Neighborhood Hits	94
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CEL_HUMAN
θ value	0.813845 (rank : 126)	NC score	0.023751 (rank : 305)
Query Neighborhood Hits	226	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

EPHB3_MOUSE
θ value	0.813845 (rank : 127)	NC score	0.038998 (rank : 281)
Query Neighborhood Hits	226	Target Neighborhood Hits	996	Shared Neighborhood Hits	29
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

GRIN1_HUMAN
θ value	0.813845 (rank : 128)	NC score	0.032648 (rank : 288)
Query Neighborhood Hits	226	Target Neighborhood Hits	681	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

JHD3C_HUMAN
θ value	0.813845 (rank : 129)	NC score	0.016209 (rank : 319)
Query Neighborhood Hits	226	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

JPH2_HUMAN
θ value	0.813845 (rank : 130)	NC score	0.030096 (rank : 292)
Query Neighborhood Hits	226	Target Neighborhood Hits	639	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LZTS2_MOUSE
θ value	0.813845 (rank : 131)	NC score	0.032256 (rank : 289)
Query Neighborhood Hits	226	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

SON_HUMAN
θ value	0.813845 (rank : 132)	NC score	0.031900 (rank : 290)
Query Neighborhood Hits	226	Target Neighborhood Hits	1568	Shared Neighborhood Hits	54
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SRBS1_MOUSE
θ value	0.813845 (rank : 133)	NC score	0.299287 (rank : 41)
Query Neighborhood Hits	226	Target Neighborhood Hits	409	Shared Neighborhood Hits	138
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TEC_MOUSE
θ value	0.813845 (rank : 134)	NC score	0.075816 (rank : 190)
Query Neighborhood Hits	226	Target Neighborhood Hits	1006	Shared Neighborhood Hits	106
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

AKAP1_MOUSE
θ value	1.06291 (rank : 135)	NC score	0.028362 (rank : 298)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

DDEF1_MOUSE
θ value	1.06291 (rank : 136)	NC score	0.148638 (rank : 127)
Query Neighborhood Hits	226	Target Neighborhood Hits	592	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GA2L1_MOUSE
θ value	1.06291 (rank : 137)	NC score	0.028182 (rank : 300)
Query Neighborhood Hits	226	Target Neighborhood Hits	114	Shared Neighborhood Hits	13
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

SRGP1_HUMAN
θ value	1.06291 (rank : 138)	NC score	0.177697 (rank : 108)
Query Neighborhood Hits	226	Target Neighborhood Hits	390	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

ASPP1_MOUSE
θ value	1.38821 (rank : 139)	NC score	0.155574 (rank : 120)
Query Neighborhood Hits	226	Target Neighborhood Hits	1244	Shared Neighborhood Hits	151
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CDSN_MOUSE
θ value	1.38821 (rank : 140)	NC score	0.044642 (rank : 275)
Query Neighborhood Hits	226	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

DLG2_HUMAN
θ value	1.38821 (rank : 141)	NC score	0.046148 (rank : 273)
Query Neighborhood Hits	226	Target Neighborhood Hits	279	Shared Neighborhood Hits	62
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

ES8L2_MOUSE
θ value	1.38821 (rank : 142)	NC score	0.138269 (rank : 134)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	92
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

INVS_MOUSE
θ value	1.38821 (rank : 143)	NC score	0.013350 (rank : 325)
Query Neighborhood Hits	226	Target Neighborhood Hits	609	Shared Neighborhood Hits	24
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

KBTBB_MOUSE
θ value	1.38821 (rank : 144)	NC score	0.013451 (rank : 323)
Query Neighborhood Hits	226	Target Neighborhood Hits	184	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BNW9	Gene names	Kbtbd11, Kiaa0711
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 11.

SRBS1_HUMAN
θ value	1.38821 (rank : 145)	NC score	0.293665 (rank : 46)
Query Neighborhood Hits	226	Target Neighborhood Hits	396	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SREC_HUMAN
θ value	1.38821 (rank : 146)	NC score	0.006512 (rank : 337)
Query Neighborhood Hits	226	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

TCGAP_MOUSE
θ value	1.38821 (rank : 147)	NC score	0.127583 (rank : 138)
Query Neighborhood Hits	226	Target Neighborhood Hits	409	Shared Neighborhood Hits	102
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ULK1_MOUSE
θ value	1.38821 (rank : 148)	NC score	0.021477 (rank : 310)
Query Neighborhood Hits	226	Target Neighborhood Hits	1214	Shared Neighborhood Hits	53
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ES8L2_HUMAN
θ value	1.81305 (rank : 149)	NC score	0.139310 (rank : 132)
Query Neighborhood Hits	226	Target Neighborhood Hits	193	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

LYN_MOUSE
θ value	1.81305 (rank : 150)	NC score	0.081402 (rank : 178)
Query Neighborhood Hits	226	Target Neighborhood Hits	1023	Shared Neighborhood Hits	114
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SALL3_HUMAN
θ value	1.81305 (rank : 151)	NC score	0.005113 (rank : 340)
Query Neighborhood Hits	226	Target Neighborhood Hits	1066	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

TCGAP_HUMAN
θ value	1.81305 (rank : 152)	NC score	0.117889 (rank : 142)
Query Neighborhood Hits	226	Target Neighborhood Hits	872	Shared Neighborhood Hits	115
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ZN541_HUMAN
θ value	1.81305 (rank : 153)	NC score	0.024731 (rank : 304)
Query Neighborhood Hits	226	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

ASPP1_HUMAN
θ value	2.36792 (rank : 154)	NC score	0.154752 (rank : 123)
Query Neighborhood Hits	226	Target Neighborhood Hits	956	Shared Neighborhood Hits	138
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CTDP1_HUMAN
θ value	2.36792 (rank : 155)	NC score	0.046194 (rank : 272)
Query Neighborhood Hits	226	Target Neighborhood Hits	416	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

FNBP2_HUMAN
θ value	2.36792 (rank : 156)	NC score	0.170509 (rank : 113)
Query Neighborhood Hits	226	Target Neighborhood Hits	432	Shared Neighborhood Hits	120
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

MPP5_HUMAN
θ value	2.36792 (rank : 157)	NC score	0.066667 (rank : 216)
Query Neighborhood Hits	226	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	2.36792 (rank : 158)	NC score	0.066185 (rank : 217)
Query Neighborhood Hits	226	Target Neighborhood Hits	226	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

NCF1_MOUSE
θ value	2.36792 (rank : 159)	NC score	0.251956 (rank : 71)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NEK1_MOUSE
θ value	2.36792 (rank : 160)	NC score	0.017954 (rank : 315)
Query Neighborhood Hits	226	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

T22D4_HUMAN
θ value	2.36792 (rank : 161)	NC score	0.032880 (rank : 287)
Query Neighborhood Hits	226	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TTC28_HUMAN
θ value	2.36792 (rank : 162)	NC score	0.019898 (rank : 311)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	11
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

AMPH_HUMAN
θ value	3.0926 (rank : 163)	NC score	0.095264 (rank : 165)
Query Neighborhood Hits	226	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

CJ119_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.029431 (rank : 293)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BTE3, Q6IA56, Q9BVT9, Q9H916	Gene names	C10orf119
Domain Architecture	No domain graphic available
Description	Protein C10orf119.

DIDO1_HUMAN
θ value	3.0926 (rank : 165)	NC score	0.019577 (rank : 312)
Query Neighborhood Hits	226	Target Neighborhood Hits	960	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DOK7_MOUSE
θ value	3.0926 (rank : 166)	NC score	0.026998 (rank : 302)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

HCN2_MOUSE
θ value	3.0926 (rank : 167)	NC score	0.019220 (rank : 313)
Query Neighborhood Hits	226	Target Neighborhood Hits	278	Shared Neighborhood Hits	27
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

MBB1A_HUMAN
θ value	3.0926 (rank : 168)	NC score	0.022256 (rank : 308)
Query Neighborhood Hits	226	Target Neighborhood Hits	665	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

NCK2_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.271956 (rank : 63)
Query Neighborhood Hits	226	Target Neighborhood Hits	310	Shared Neighborhood Hits	133
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NOXO1_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.177683 (rank : 109)
Query Neighborhood Hits	226	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

OGFR_HUMAN
θ value	3.0926 (rank : 171)	NC score	0.047746 (rank : 270)
Query Neighborhood Hits	226	Target Neighborhood Hits	1582	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PLCG1_MOUSE
θ value	3.0926 (rank : 172)	NC score	0.174991 (rank : 110)
Query Neighborhood Hits	226	Target Neighborhood Hits	314	Shared Neighborhood Hits	119
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PSL1_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.035776 (rank : 285)
Query Neighborhood Hits	226	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PVRL2_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.012246 (rank : 328)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

RIMB1_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.088473 (rank : 172)
Query Neighborhood Hits	226	Target Neighborhood Hits	1376	Shared Neighborhood Hits	126
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SEM3B_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.005234 (rank : 339)
Query Neighborhood Hits	226	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

SNX18_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.179557 (rank : 106)
Query Neighborhood Hits	226	Target Neighborhood Hits	207	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	3.0926 (rank : 178)	NC score	0.185297 (rank : 102)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

DGKG_MOUSE
θ value	4.03905 (rank : 179)	NC score	0.007497 (rank : 335)
Query Neighborhood Hits	226	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DLG2_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.045681 (rank : 274)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

GLIS3_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.006194 (rank : 338)
Query Neighborhood Hits	226	Target Neighborhood Hits	758	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

GP124_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.003608 (rank : 342)
Query Neighborhood Hits	226	Target Neighborhood Hits	304	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

MATK_MOUSE
θ value	4.03905 (rank : 183)	NC score	0.052083 (rank : 257)
Query Neighborhood Hits	226	Target Neighborhood Hits	952	Shared Neighborhood Hits	63
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MYOD1_HUMAN
θ value	4.03905 (rank : 184)	NC score	0.014747 (rank : 321)
Query Neighborhood Hits	226	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

NCF1_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.251424 (rank : 72)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	118
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SPEG_MOUSE
θ value	4.03905 (rank : 186)	NC score	0.017483 (rank : 317)
Query Neighborhood Hits	226	Target Neighborhood Hits	1959	Shared Neighborhood Hits	71
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SRTD1_MOUSE
θ value	4.03905 (rank : 187)	NC score	0.036293 (rank : 282)
Query Neighborhood Hits	226	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

TEC_HUMAN
θ value	4.03905 (rank : 188)	NC score	0.075443 (rank : 192)
Query Neighborhood Hits	226	Target Neighborhood Hits	1006	Shared Neighborhood Hits	103
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZIMP7_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.017527 (rank : 316)
Query Neighborhood Hits	226	Target Neighborhood Hits	566	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZO2_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.022403 (rank : 307)
Query Neighborhood Hits	226	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

BAT3_MOUSE
θ value	5.27518 (rank : 191)	NC score	0.030349 (rank : 291)
Query Neighborhood Hits	226	Target Neighborhood Hits	518	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BSCL2_MOUSE
θ value	5.27518 (rank : 192)	NC score	0.018664 (rank : 314)
Query Neighborhood Hits	226	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

CIC_MOUSE
θ value	5.27518 (rank : 193)	NC score	0.029350 (rank : 295)
Query Neighborhood Hits	226	Target Neighborhood Hits	742	Shared Neighborhood Hits	48
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CJ119_MOUSE
θ value	5.27518 (rank : 194)	NC score	0.027020 (rank : 301)
Query Neighborhood Hits	226	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3C0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf119 homolog.

DLG4_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.040167 (rank : 279)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	57
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

EPHB3_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.035939 (rank : 284)
Query Neighborhood Hits	226	Target Neighborhood Hits	996	Shared Neighborhood Hits	28
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

FOXL1_MOUSE
θ value	5.27518 (rank : 197)	NC score	0.003833 (rank : 341)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

JHD2B_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.009245 (rank : 333)
Query Neighborhood Hits	226	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

LYN_HUMAN
θ value	5.27518 (rank : 199)	NC score	0.079994 (rank : 182)
Query Neighborhood Hits	226	Target Neighborhood Hits	1022	Shared Neighborhood Hits	116
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MUC1_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.028904 (rank : 296)
Query Neighborhood Hits	226	Target Neighborhood Hits	975	Shared Neighborhood Hits	45
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NACAM_MOUSE
θ value	5.27518 (rank : 201)	NC score	0.042036 (rank : 278)
Query Neighborhood Hits	226	Target Neighborhood Hits	1866	Shared Neighborhood Hits	80
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RM49_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.046591 (rank : 271)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q13405	Gene names	MRPL49, C11orf4, NOF1
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49) (Protein NOF1) (Neighbor of FAU) (NOF).

SRCA_MOUSE
θ value	5.27518 (rank : 203)	NC score	0.013446 (rank : 324)
Query Neighborhood Hits	226	Target Neighborhood Hits	212	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

ADAM8_MOUSE
θ value	6.88961 (rank : 204)	NC score	0.003067 (rank : 343)
Query Neighborhood Hits	226	Target Neighborhood Hits	326	Shared Neighborhood Hits	10
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

ARHG7_MOUSE
θ value	6.88961 (rank : 205)	NC score	0.224800 (rank : 89)
Query Neighborhood Hits	226	Target Neighborhood Hits	396	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CO039_HUMAN
θ value	6.88961 (rank : 206)	NC score	0.035999 (rank : 283)
Query Neighborhood Hits	226	Target Neighborhood Hits	264	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

GAK_MOUSE
θ value	6.88961 (rank : 207)	NC score	0.014697 (rank : 322)
Query Neighborhood Hits	226	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GR65_MOUSE
θ value	6.88961 (rank : 208)	NC score	0.011385 (rank : 330)
Query Neighborhood Hits	226	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

MA1B1_HUMAN
θ value	6.88961 (rank : 209)	NC score	0.009502 (rank : 332)
Query Neighborhood Hits	226	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

NOXO1_HUMAN
θ value	6.88961 (rank : 210)	NC score	0.133331 (rank : 135)
Query Neighborhood Hits	226	Target Neighborhood Hits	100	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SH3K1_MOUSE
θ value	6.88961 (rank : 211)	NC score	0.283912 (rank : 54)
Query Neighborhood Hits	226	Target Neighborhood Hits	332	Shared Neighborhood Hits	137
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SLY_MOUSE
θ value	6.88961 (rank : 212)	NC score	0.065683 (rank : 219)
Query Neighborhood Hits	226	Target Neighborhood Hits	108	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

TNC6B_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.015204 (rank : 320)
Query Neighborhood Hits	226	Target Neighborhood Hits	256	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

VLDLR_HUMAN
θ value	6.88961 (rank : 214)	NC score	0.001472 (rank : 346)
Query Neighborhood Hits	226	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

ZN516_MOUSE
θ value	6.88961 (rank : 215)	NC score	0.001751 (rank : 345)
Query Neighborhood Hits	226	Target Neighborhood Hits	1197	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZO2_MOUSE
θ value	6.88961 (rank : 216)	NC score	0.021593 (rank : 309)
Query Neighborhood Hits	226	Target Neighborhood Hits	296	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CSKI1_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.028737 (rank : 297)
Query Neighborhood Hits	226	Target Neighborhood Hits	997	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ES8L3_HUMAN
θ value	8.99809 (rank : 218)	NC score	0.140619 (rank : 130)
Query Neighborhood Hits	226	Target Neighborhood Hits	206	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GEMI2_MOUSE
θ value	8.99809 (rank : 219)	NC score	0.012681 (rank : 327)
Query Neighborhood Hits	226	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQQ4, Q9DAD7	Gene names	Sip1, Gemin2
Domain Architecture	No domain graphic available
Description	Survival of motor neuron protein-interacting protein 1 (SMN- interacting protein 1) (Component of gems 2) (Gemin-2).

JIP2_HUMAN
θ value	8.99809 (rank : 220)	NC score	0.057272 (rank : 241)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LZTS2_HUMAN
θ value	8.99809 (rank : 221)	NC score	0.023479 (rank : 306)
Query Neighborhood Hits	226	Target Neighborhood Hits	427	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

MADCA_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.028219 (rank : 299)
Query Neighborhood Hits	226	Target Neighborhood Hits	221	Shared Neighborhood Hits	23
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

PRGR_MOUSE
θ value	8.99809 (rank : 223)	NC score	0.002581 (rank : 344)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	10
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

RPGF1_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.011808 (rank : 329)
Query Neighborhood Hits	226	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

TDRKH_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.016539 (rank : 318)
Query Neighborhood Hits	226	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

TNNT2_HUMAN
θ value	8.99809 (rank : 226)	NC score	0.013340 (rank : 326)
Query Neighborhood Hits	226	Target Neighborhood Hits	433	Shared Neighborhood Hits	10
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

3BP1_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.053043 (rank : 255)
Query Neighborhood Hits	226	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.248517 (rank : 77)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	115
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.251325 (rank : 73)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.067540 (rank : 214)
Query Neighborhood Hits	226	Target Neighborhood Hits	1220	Shared Neighborhood Hits	103
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.068300 (rank : 210)
Query Neighborhood Hits	226	Target Neighborhood Hits	1178	Shared Neighborhood Hits	103
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.064585 (rank : 221)
Query Neighborhood Hits	226	Target Neighborhood Hits	1045	Shared Neighborhood Hits	86
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

AMPH_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.073106 (rank : 195)
Query Neighborhood Hits	226	Target Neighborhood Hits	291	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

APS_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.057982 (rank : 239)
Query Neighborhood Hits	226	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG3_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.051661 (rank : 259)
Query Neighborhood Hits	226	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.051017 (rank : 261)
Query Neighborhood Hits	226	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.158348 (rank : 118)
Query Neighborhood Hits	226	Target Neighborhood Hits	242	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.110775 (rank : 150)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.081034 (rank : 179)
Query Neighborhood Hits	226	Target Neighborhood Hits	172	Shared Neighborhood Hits	58
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.190494 (rank : 98)
Query Neighborhood Hits	226	Target Neighborhood Hits	376	Shared Neighborhood Hits	129
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.196547 (rank : 95)
Query Neighborhood Hits	226	Target Neighborhood Hits	394	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.214081 (rank : 91)
Query Neighborhood Hits	226	Target Neighborhood Hits	347	Shared Neighborhood Hits	135
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG8_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.050534 (rank : 263)
Query Neighborhood Hits	226	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.050108 (rank : 265)
Query Neighborhood Hits	226	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.058474 (rank : 235)
Query Neighborhood Hits	226	Target Neighborhood Hits	129	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.068803 (rank : 208)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.111364 (rank : 149)
Query Neighborhood Hits	226	Target Neighborhood Hits	1156	Shared Neighborhood Hits	120
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.050102 (rank : 266)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BI2L1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.050388 (rank : 264)
Query Neighborhood Hits	226	Target Neighborhood Hits	156	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.076214 (rank : 188)
Query Neighborhood Hits	226	Target Neighborhood Hits	335	Shared Neighborhood Hits	64
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.069520 (rank : 204)
Query Neighborhood Hits	226	Target Neighborhood Hits	283	Shared Neighborhood Hits	61
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CIP4_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.107562 (rank : 152)
Query Neighborhood Hits	226	Target Neighborhood Hits	374	Shared Neighborhood Hits	64
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSK_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.067667 (rank : 213)
Query Neighborhood Hits	226	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.067743 (rank : 212)
Query Neighborhood Hits	226	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DAPP1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.063634 (rank : 222)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.065229 (rank : 220)
Query Neighborhood Hits	226	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DOCK1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.068997 (rank : 206)
Query Neighborhood Hits	226	Target Neighborhood Hits	191	Shared Neighborhood Hits	82
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

EM55_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.056881 (rank : 244)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.054485 (rank : 251)
Query Neighborhood Hits	226	Target Neighborhood Hits	221	Shared Neighborhood Hits	66
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EPS8_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.104429 (rank : 155)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	80
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.111884 (rank : 148)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	91
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.112999 (rank : 147)
Query Neighborhood Hits	226	Target Neighborhood Hits	162	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.113675 (rank : 144)
Query Neighborhood Hits	226	Target Neighborhood Hits	143	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.155514 (rank : 122)
Query Neighborhood Hits	226	Target Neighborhood Hits	168	Shared Neighborhood Hits	104
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

GPS2_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.051839 (rank : 258)
Query Neighborhood Hits	226	Target Neighborhood Hits	459	Shared Neighborhood Hits	20
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GRB14_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.057852 (rank : 240)
Query Neighborhood Hits	226	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.056697 (rank : 246)
Query Neighborhood Hits	226	Target Neighborhood Hits	149	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HCK_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.087473 (rank : 174)
Query Neighborhood Hits	226	Target Neighborhood Hits	1035	Shared Neighborhood Hits	130
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.086108 (rank : 175)
Query Neighborhood Hits	226	Target Neighborhood Hits	1029	Shared Neighborhood Hits	128
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ITK_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.070311 (rank : 202)
Query Neighborhood Hits	226	Target Neighborhood Hits	1016	Shared Neighborhood Hits	104
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.065793 (rank : 218)
Query Neighborhood Hits	226	Target Neighborhood Hits	985	Shared Neighborhood Hits	94
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LCK_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.071886 (rank : 198)
Query Neighborhood Hits	226	Target Neighborhood Hits	987	Shared Neighborhood Hits	86
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.070655 (rank : 201)
Query Neighborhood Hits	226	Target Neighborhood Hits	981	Shared Neighborhood Hits	85
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.052385 (rank : 256)
Query Neighborhood Hits	226	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.054595 (rank : 250)
Query Neighborhood Hits	226	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.056848 (rank : 245)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

M3K10_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.066910 (rank : 215)
Query Neighborhood Hits	226	Target Neighborhood Hits	1071	Shared Neighborhood Hits	123
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.078108 (rank : 185)
Query Neighborhood Hits	226	Target Neighborhood Hits	1136	Shared Neighborhood Hits	143
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.070147 (rank : 203)
Query Neighborhood Hits	226	Target Neighborhood Hits	1123	Shared Neighborhood Hits	133
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.086082 (rank : 176)
Query Neighborhood Hits	226	Target Neighborhood Hits	1087	Shared Neighborhood Hits	137
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MPP6_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.060276 (rank : 229)
Query Neighborhood Hits	226	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.057984 (rank : 238)
Query Neighborhood Hits	226	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MYO1E_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.113323 (rank : 145)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

NGEF_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.080312 (rank : 180)
Query Neighborhood Hits	226	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.078913 (rank : 184)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

P55G_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.060356 (rank : 228)
Query Neighborhood Hits	226	Target Neighborhood Hits	451	Shared Neighborhood Hits	41
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.060167 (rank : 230)
Query Neighborhood Hits	226	Target Neighborhood Hits	401	Shared Neighborhood Hits	40
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.090523 (rank : 168)
Query Neighborhood Hits	226	Target Neighborhood Hits	479	Shared Neighborhood Hits	81
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.094879 (rank : 166)
Query Neighborhood Hits	226	Target Neighborhood Hits	435	Shared Neighborhood Hits	85
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.074714 (rank : 193)
Query Neighborhood Hits	226	Target Neighborhood Hits	543	Shared Neighborhood Hits	64
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.070853 (rank : 200)
Query Neighborhood Hits	226	Target Neighborhood Hits	519	Shared Neighborhood Hits	61
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PEX13_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.182852 (rank : 105)
Query Neighborhood Hits	226	Target Neighborhood Hits	128	Shared Neighborhood Hits	86
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.179071 (rank : 107)
Query Neighborhood Hits	226	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.163183 (rank : 117)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	115
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PPIP2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.076985 (rank : 187)
Query Neighborhood Hits	226	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PPIP2_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.072439 (rank : 197)
Query Neighborhood Hits	226	Target Neighborhood Hits	308	Shared Neighborhood Hits	15
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRP2_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.050988 (rank : 262)
Query Neighborhood Hits	226	Target Neighborhood Hits	347	Shared Neighborhood Hits	41
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PTK6_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.068344 (rank : 209)
Query Neighborhood Hits	226	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.068925 (rank : 207)
Query Neighborhood Hits	226	Target Neighborhood Hits	1026	Shared Neighborhood Hits	116
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RASA1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.089783 (rank : 170)
Query Neighborhood Hits	226	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RHG26_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.130943 (rank : 136)
Query Neighborhood Hits	226	Target Neighborhood Hits	281	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.090151 (rank : 169)
Query Neighborhood Hits	226	Target Neighborhood Hits	1479	Shared Neighborhood Hits	125
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.140335 (rank : 131)
Query Neighborhood Hits	226	Target Neighborhood Hits	263	Shared Neighborhood Hits	92
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.139232 (rank : 133)
Query Neighborhood Hits	226	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SH21A_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.057000 (rank : 243)
Query Neighborhood Hits	226	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.058288 (rank : 236)
Query Neighborhood Hits	226	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.075493 (rank : 191)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.077548 (rank : 186)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.281097 (rank : 60)
Query Neighborhood Hits	226	Target Neighborhood Hits	341	Shared Neighborhood Hits	137
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SHAN1_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.069039 (rank : 205)
Query Neighborhood Hits	226	Target Neighborhood Hits	1041	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.073302 (rank : 194)
Query Neighborhood Hits	226	Target Neighborhood Hits	446	Shared Neighborhood Hits	89
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.051278 (rank : 260)
Query Neighborhood Hits	226	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.058523 (rank : 233)
Query Neighborhood Hits	226	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.056645 (rank : 247)
Query Neighborhood Hits	226	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.054113 (rank : 252)
Query Neighborhood Hits	226	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.053605 (rank : 254)
Query Neighborhood Hits	226	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.055471 (rank : 248)
Query Neighborhood Hits	226	Target Neighborhood Hits	155	Shared Neighborhood Hits	35
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.057012 (rank : 242)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHE_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.058191 (rank : 237)
Query Neighborhood Hits	226	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.059749 (rank : 231)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.108419 (rank : 151)
Query Neighborhood Hits	226	Target Neighborhood Hits	113	Shared Neighborhood Hits	35
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.107188 (rank : 153)
Query Neighborhood Hits	226	Target Neighborhood Hits	117	Shared Neighborhood Hits	35
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.118488 (rank : 141)
Query Neighborhood Hits	226	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.117874 (rank : 143)
Query Neighborhood Hits	226	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SNX9_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.103711 (rank : 156)
Query Neighborhood Hits	226	Target Neighborhood Hits	148	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.091753 (rank : 167)
Query Neighborhood Hits	226	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SPN90_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.126334 (rank : 140)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.113016 (rank : 146)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRMS_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.055245 (rank : 249)
Query Neighborhood Hits	226	Target Neighborhood Hits	946	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.061509 (rank : 225)
Query Neighborhood Hits	226	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC3_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.201048 (rank : 93)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	114
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.200403 (rank : 94)
Query Neighborhood Hits	226	Target Neighborhood Hits	232	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.226950 (rank : 88)
Query Neighborhood Hits	226	Target Neighborhood Hits	276	Shared Neighborhood Hits	129
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.220102 (rank : 90)
Query Neighborhood Hits	226	Target Neighborhood Hits	268	Shared Neighborhood Hits	126
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STS1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.072944 (rank : 196)
Query Neighborhood Hits	226	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.071856 (rank : 199)
Query Neighborhood Hits	226	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.089538 (rank : 171)
Query Neighborhood Hits	226	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TAF4_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.058519 (rank : 234)
Query Neighborhood Hits	226	Target Neighborhood Hits	687	Shared Neighborhood Hits	45
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TXK_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.068205 (rank : 211)
Query Neighborhood Hits	226	Target Neighborhood Hits	971	Shared Neighborhood Hits	96
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.075951 (rank : 189)
Query Neighborhood Hits	226	Target Neighborhood Hits	980	Shared Neighborhood Hits	108
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.170220 (rank : 114)
Query Neighborhood Hits	226	Target Neighborhood Hits	453	Shared Neighborhood Hits	126
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.171505 (rank : 112)
Query Neighborhood Hits	226	Target Neighborhood Hits	456	Shared Neighborhood Hits	127
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.157297 (rank : 119)
Query Neighborhood Hits	226	Target Neighborhood Hits	398	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.153541 (rank : 124)
Query Neighborhood Hits	226	Target Neighborhood Hits	404	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.185193 (rank : 103)
Query Neighborhood Hits	226	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.183596 (rank : 104)
Query Neighborhood Hits	226	Target Neighborhood Hits	430	Shared Neighborhood Hits	132
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

RUSC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	226	Target Neighborhood Hits	226	Shared Neighborhood Hits	226
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
NC score	0.957171 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	226	Target Neighborhood Hits	206	Shared Neighborhood Hits	138
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

RUSC2_HUMAN
NC score	0.711900 (rank : 3)	θ value	3.0428e-56 (rank : 4)
Query Neighborhood Hits	226	Target Neighborhood Hits	205	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
NC score	0.686593 (rank : 4)	θ value	6.13105e-57 (rank : 3)
Query Neighborhood Hits	226	Target Neighborhood Hits	305	Shared Neighborhood Hits	64
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

NCF2_HUMAN
NC score	0.386802 (rank : 5)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	226	Target Neighborhood Hits	229	Shared Neighborhood Hits	124
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

EFS_MOUSE
NC score	0.371007 (rank : 6)	θ value	5.44631e-05 (rank : 8)
Query Neighborhood Hits	226	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

PPIP1_HUMAN
NC score	0.370952 (rank : 7)	θ value	0.00020696 (rank : 13)
Query Neighborhood Hits	226	Target Neighborhood Hits	389	Shared Neighborhood Hits	140
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

EFS_HUMAN
NC score	0.368350 (rank : 8)	θ value	5.44631e-05 (rank : 7)
Query Neighborhood Hits	226	Target Neighborhood Hits	348	Shared Neighborhood Hits	131
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ABI2_HUMAN
NC score	0.364970 (rank : 9)	θ value	0.00035302 (rank : 14)
Query Neighborhood Hits	226	Target Neighborhood Hits	350	Shared Neighborhood Hits	145
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
NC score	0.364890 (rank : 10)	θ value	9.29e-05 (rank : 10)
Query Neighborhood Hits	226	Target Neighborhood Hits	266	Shared Neighborhood Hits	134
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

VINEX_MOUSE
NC score	0.348175 (rank : 11)	θ value	0.00665767 (rank : 30)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	138
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

PPIP1_MOUSE
NC score	0.348106 (rank : 12)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	226	Target Neighborhood Hits	377	Shared Neighborhood Hits	138
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

HCLS1_HUMAN
NC score	0.340642 (rank : 13)	θ value	0.163984 (rank : 75)
Query Neighborhood Hits	226	Target Neighborhood Hits	358	Shared Neighborhood Hits	138
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

VINEX_HUMAN
NC score	0.335786 (rank : 14)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	226	Target Neighborhood Hits	270	Shared Neighborhood Hits	136
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

HCLS1_MOUSE
NC score	0.331614 (rank : 15)	θ value	0.279714 (rank : 90)
Query Neighborhood Hits	226	Target Neighborhood Hits	329	Shared Neighborhood Hits	140
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI1_MOUSE
NC score	0.329623 (rank : 16)	θ value	0.0113563 (rank : 35)
Query Neighborhood Hits	226	Target Neighborhood Hits	246	Shared Neighborhood Hits	132
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

SH3G2_MOUSE
NC score	0.328121 (rank : 17)	θ value	0.0736092 (rank : 65)
Query Neighborhood Hits	226	Target Neighborhood Hits	319	Shared Neighborhood Hits	134
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_HUMAN
NC score	0.327127 (rank : 18)	θ value	0.0330416 (rank : 49)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	126
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CD2AP_MOUSE
NC score	0.323353 (rank : 19)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	226	Target Neighborhood Hits	336	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3G3_MOUSE
NC score	0.321687 (rank : 20)	θ value	0.279714 (rank : 96)
Query Neighborhood Hits	226	Target Neighborhood Hits	236	Shared Neighborhood Hits	130
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NCF4_MOUSE
NC score	0.321553 (rank : 21)	θ value	0.163984 (rank : 76)
Query Neighborhood Hits	226	Target Neighborhood Hits	177	Shared Neighborhood Hits	112
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SRC8_HUMAN
NC score	0.321334 (rank : 22)	θ value	0.0961366 (rank : 69)
Query Neighborhood Hits	226	Target Neighborhood Hits	269	Shared Neighborhood Hits	132
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

GRB2_HUMAN
NC score	0.320795 (rank : 23)	θ value	0.00869519 (rank : 31)
Query Neighborhood Hits	226	Target Neighborhood Hits	310	Shared Neighborhood Hits	138
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.320356 (rank : 24)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	226	Target Neighborhood Hits	312	Shared Neighborhood Hits	138
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI1_HUMAN
NC score	0.320117 (rank : 25)	θ value	0.0193708 (rank : 42)
Query Neighborhood Hits	226	Target Neighborhood Hits	257	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

SH3G2_HUMAN
NC score	0.319982 (rank : 26)	θ value	0.0736092 (rank : 64)
Query Neighborhood Hits	226	Target Neighborhood Hits	324	Shared Neighborhood Hits	132
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

GRAP2_MOUSE
NC score	0.319897 (rank : 27)	θ value	0.0431538 (rank : 50)
Query Neighborhood Hits	226	Target Neighborhood Hits	297	Shared Neighborhood Hits	142
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G1_MOUSE
NC score	0.319356 (rank : 28)	θ value	0.0563607 (rank : 58)
Query Neighborhood Hits	226	Target Neighborhood Hits	291	Shared Neighborhood Hits	130
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SRC8_MOUSE
NC score	0.319053 (rank : 29)	θ value	0.0961366 (rank : 70)
Query Neighborhood Hits	226	Target Neighborhood Hits	292	Shared Neighborhood Hits	133
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SH3G3_HUMAN
NC score	0.317434 (rank : 30)	θ value	0.279714 (rank : 95)
Query Neighborhood Hits	226	Target Neighborhood Hits	222	Shared Neighborhood Hits	125
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

GRAP_HUMAN
NC score	0.315553 (rank : 31)	θ value	0.0193708 (rank : 43)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	139
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CRKL_HUMAN
NC score	0.315535 (rank : 32)	θ value	0.00102713 (rank : 18)
Query Neighborhood Hits	226	Target Neighborhood Hits	313	Shared Neighborhood Hits	136
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP2_HUMAN
NC score	0.314349 (rank : 33)	θ value	0.0736092 (rank : 61)
Query Neighborhood Hits	226	Target Neighborhood Hits	304	Shared Neighborhood Hits	141
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

NCF4_HUMAN
NC score	0.309821 (rank : 34)	θ value	0.365318 (rank : 100)
Query Neighborhood Hits	226	Target Neighborhood Hits	161	Shared Neighborhood Hits	103
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

CRKL_MOUSE
NC score	0.308627 (rank : 35)	θ value	0.00175202 (rank : 21)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	135
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CD2AP_HUMAN
NC score	0.306607 (rank : 36)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	226	Target Neighborhood Hits	315	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

BCAR1_MOUSE
NC score	0.305968 (rank : 37)	θ value	0.00390308 (rank : 25)
Query Neighborhood Hits	226	Target Neighborhood Hits	438	Shared Neighborhood Hits	139
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

GRAP_MOUSE
NC score	0.304761 (rank : 38)	θ value	0.0736092 (rank : 62)
Query Neighborhood Hits	226	Target Neighborhood Hits	309	Shared Neighborhood Hits	139
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

LASP1_HUMAN
NC score	0.304122 (rank : 39)	θ value	0.0148317 (rank : 39)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	114
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DBNL_HUMAN
NC score	0.300071 (rank : 40)	θ value	0.0148317 (rank : 38)
Query Neighborhood Hits	226	Target Neighborhood Hits	244	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SRBS1_MOUSE
NC score	0.299287 (rank : 41)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	226	Target Neighborhood Hits	409	Shared Neighborhood Hits	138
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NPHP1_MOUSE
NC score	0.298641 (rank : 42)	θ value	0.0330416 (rank : 48)
Query Neighborhood Hits	226	Target Neighborhood Hits	267	Shared Neighborhood Hits	129
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

STAM2_MOUSE
NC score	0.297965 (rank : 43)	θ value	0.21417 (rank : 86)
Query Neighborhood Hits	226	Target Neighborhood Hits	285	Shared Neighborhood Hits	139
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

LASP1_MOUSE
NC score	0.296178 (rank : 44)	θ value	0.0148317 (rank : 40)
Query Neighborhood Hits	226	Target Neighborhood Hits	297	Shared Neighborhood Hits	113
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BCAR1_HUMAN
NC score	0.295475 (rank : 45)	θ value	0.00390308 (rank : 24)
Query Neighborhood Hits	226	Target Neighborhood Hits	554	Shared Neighborhood Hits	144
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SRBS1_HUMAN
NC score	0.293665 (rank : 46)	θ value	1.38821 (rank : 145)
Query Neighborhood Hits	226	Target Neighborhood Hits	396	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PACN3_MOUSE
NC score	0.293193 (rank : 47)	θ value	0.00298849 (rank : 23)
Query Neighborhood Hits	226	Target Neighborhood Hits	380	Shared Neighborhood Hits	123
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

DBNL_MOUSE
NC score	0.292770 (rank : 48)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	226	Target Neighborhood Hits	306	Shared Neighborhood Hits	115
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NCK1_HUMAN
NC score	0.291152 (rank : 49)	θ value	0.0193708 (rank : 45)
Query Neighborhood Hits	226	Target Neighborhood Hits	312	Shared Neighborhood Hits	137
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAM1_HUMAN
NC score	0.290469 (rank : 50)	θ value	0.163984 (rank : 78)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	137
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.290073 (rank : 51)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	226	Target Neighborhood Hits	273	Shared Neighborhood Hits	137
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

CRK_MOUSE
NC score	0.290036 (rank : 52)	θ value	0.0961366 (rank : 67)
Query Neighborhood Hits	226	Target Neighborhood Hits	314	Shared Neighborhood Hits	132
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.288452 (rank : 53)	θ value	0.0961366 (rank : 66)
Query Neighborhood Hits	226	Target Neighborhood Hits	308	Shared Neighborhood Hits	133
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3K1_MOUSE
NC score	0.283912 (rank : 54)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	226	Target Neighborhood Hits	332	Shared Neighborhood Hits	137
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

PACN1_MOUSE
NC score	0.283630 (rank : 55)	θ value	0.47712 (rank : 110)
Query Neighborhood Hits	226	Target Neighborhood Hits	283	Shared Neighborhood Hits	127
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_MOUSE
NC score	0.283497 (rank : 56)	θ value	0.279714 (rank : 94)
Query Neighborhood Hits	226	Target Neighborhood Hits	382	Shared Neighborhood Hits	128
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
NC score	0.283481 (rank : 57)	θ value	0.00665767 (rank : 29)
Query Neighborhood Hits	226	Target Neighborhood Hits	385	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN2_HUMAN
NC score	0.282197 (rank : 58)	θ value	0.47712 (rank : 111)
Query Neighborhood Hits	226	Target Neighborhood Hits	339	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_HUMAN
NC score	0.282193 (rank : 59)	θ value	0.47712 (rank : 109)
Query Neighborhood Hits	226	Target Neighborhood Hits	320	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3K1_HUMAN
NC score	0.281097 (rank : 60)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	226	Target Neighborhood Hits	341	Shared Neighborhood Hits	137
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

STAM2_HUMAN
NC score	0.276459 (rank : 61)	θ value	0.279714 (rank : 98)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	133
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CT032_HUMAN
NC score	0.273899 (rank : 62)	θ value	0.47712 (rank : 102)
Query Neighborhood Hits	226	Target Neighborhood Hits	235	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

NCK2_HUMAN
NC score	0.271956 (rank : 63)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	226	Target Neighborhood Hits	310	Shared Neighborhood Hits	133
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

DNMBP_HUMAN
NC score	0.271407 (rank : 64)	θ value	0.125558 (rank : 71)
Query Neighborhood Hits	226	Target Neighborhood Hits	413	Shared Neighborhood Hits	139
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

CASL_MOUSE
NC score	0.264557 (rank : 65)	θ value	0.0736092 (rank : 60)
Query Neighborhood Hits	226	Target Neighborhood Hits	225	Shared Neighborhood Hits	113
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.264030 (rank : 66)	θ value	0.0736092 (rank : 59)
Query Neighborhood Hits	226	Target Neighborhood Hits	259	Shared Neighborhood Hits	118
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NEBL_HUMAN
NC score	0.263180 (rank : 67)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	226	Target Neighborhood Hits	457	Shared Neighborhood Hits	117
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NPHP1_HUMAN
NC score	0.262767 (rank : 68)	θ value	0.47712 (rank : 108)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	120
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

AHI1_MOUSE
NC score	0.257293 (rank : 69)	θ value	0.00175202 (rank : 20)
Query Neighborhood Hits	226	Target Neighborhood Hits	496	Shared Neighborhood Hits	136
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SHLB2_MOUSE
NC score	0.253809 (rank : 70)	θ value	0.000786445 (rank : 17)
Query Neighborhood Hits	226	Target Neighborhood Hits	88	Shared Neighborhood Hits	58
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

NCF1_MOUSE
NC score	0.251956 (rank : 71)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF1_HUMAN
NC score	0.251424 (rank : 72)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	118
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ABI3_MOUSE
NC score	0.251325 (rank : 73)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SHLB2_HUMAN
NC score	0.251153 (rank : 74)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	226	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

DNMBP_MOUSE
NC score	0.250729 (rank : 75)	θ value	0.279714 (rank : 89)
Query Neighborhood Hits	226	Target Neighborhood Hits	435	Shared Neighborhood Hits	141
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SHLB1_MOUSE
NC score	0.249085 (rank : 76)	θ value	0.0113563 (rank : 37)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

ABI3_HUMAN
NC score	0.248517 (rank : 77)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	115
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN2_HUMAN
NC score	0.246942 (rank : 78)	θ value	0.00665767 (rank : 28)
Query Neighborhood Hits	226	Target Neighborhood Hits	1173	Shared Neighborhood Hits	146
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SHLB1_HUMAN
NC score	0.245789 (rank : 79)	θ value	0.0148317 (rank : 41)
Query Neighborhood Hits	226	Target Neighborhood Hits	96	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

NEBU_HUMAN
NC score	0.245267 (rank : 80)	θ value	0.00869519 (rank : 34)
Query Neighborhood Hits	226	Target Neighborhood Hits	420	Shared Neighborhood Hits	117
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

AHI1_HUMAN
NC score	0.244672 (rank : 81)	θ value	0.00665767 (rank : 27)
Query Neighborhood Hits	226	Target Neighborhood Hits	537	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

RHG04_HUMAN
NC score	0.243635 (rank : 82)	θ value	7.1131e-05 (rank : 9)
Query Neighborhood Hits	226	Target Neighborhood Hits	307	Shared Neighborhood Hits	120
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ITSN1_MOUSE
NC score	0.242128 (rank : 83)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	226	Target Neighborhood Hits	1669	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

OSTF1_HUMAN
NC score	0.241719 (rank : 84)	θ value	0.279714 (rank : 93)
Query Neighborhood Hits	226	Target Neighborhood Hits	466	Shared Neighborhood Hits	136
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ITSN1_HUMAN
NC score	0.241209 (rank : 85)	θ value	8.40245e-06 (rank : 6)
Query Neighborhood Hits	226	Target Neighborhood Hits	1757	Shared Neighborhood Hits	156
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_MOUSE
NC score	0.234015 (rank : 86)	θ value	0.00228821 (rank : 22)
Query Neighborhood Hits	226	Target Neighborhood Hits	1371	Shared Neighborhood Hits	145
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

OSTF1_MOUSE
NC score	0.232263 (rank : 87)	θ value	0.62314 (rank : 119)
Query Neighborhood Hits	226	Target Neighborhood Hits	467	Shared Neighborhood Hits	134
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

STAC_HUMAN
NC score	0.226950 (rank : 88)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	226	Target Neighborhood Hits	276	Shared Neighborhood Hits	129
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_MOUSE
NC score	0.224800 (rank : 89)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	226	Target Neighborhood Hits	396	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

STAC_MOUSE
NC score	0.220102 (rank : 90)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	226	Target Neighborhood Hits	268	Shared Neighborhood Hits	126
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ARHG7_HUMAN
NC score	0.214081 (rank : 91)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	226	Target Neighborhood Hits	347	Shared Neighborhood Hits	135
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

IASPP_HUMAN
NC score	0.211465 (rank : 92)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	226	Target Neighborhood Hits	688	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

STAC3_HUMAN
NC score	0.201048 (rank : 93)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	114
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
NC score	0.200403 (rank : 94)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	226	Target Neighborhood Hits	232	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG6_MOUSE
NC score	0.196547 (rank : 95)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	226	Target Neighborhood Hits	394	Shared Neighborhood Hits	128
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SRGP2_MOUSE
NC score	0.193047 (rank : 96)	θ value	0.163984 (rank : 77)
Query Neighborhood Hits	226	Target Neighborhood Hits	324	Shared Neighborhood Hits	117
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

ANM2_HUMAN
NC score	0.191115 (rank : 97)	θ value	0.813845 (rank : 123)
Query Neighborhood Hits	226	Target Neighborhood Hits	175	Shared Neighborhood Hits	114
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_HUMAN
NC score	0.190494 (rank : 98)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	226	Target Neighborhood Hits	376	Shared Neighborhood Hits	129
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ANM2_MOUSE
NC score	0.190437 (rank : 99)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	226	Target Neighborhood Hits	175	Shared Neighborhood Hits	112
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SRGP2_HUMAN
NC score	0.189994 (rank : 100)	θ value	0.21417 (rank : 85)
Query Neighborhood Hits	226	Target Neighborhood Hits	331	Shared Neighborhood Hits	115
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

IASPP_MOUSE
NC score	0.189303 (rank : 101)	θ value	0.0563607 (rank : 56)
Query Neighborhood Hits	226	Target Neighborhood Hits	1024	Shared Neighborhood Hits	147
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SNX18_MOUSE
NC score	0.185297 (rank : 102)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	102
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

VAV_HUMAN
NC score	0.185193 (rank : 103)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	226	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.183596 (rank : 104)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	226	Target Neighborhood Hits	430	Shared Neighborhood Hits	132
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

PEX13_HUMAN
NC score	0.182852 (rank : 105)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	226	Target Neighborhood Hits	128	Shared Neighborhood Hits	86
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SNX18_HUMAN
NC score	0.179557 (rank : 106)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	226	Target Neighborhood Hits	207	Shared Neighborhood Hits	99
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PEX13_MOUSE
NC score	0.179071 (rank : 107)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	226	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SRGP1_HUMAN
NC score	0.177697 (rank : 108)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	226	Target Neighborhood Hits	390	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

NOXO1_MOUSE
NC score	0.177683 (rank : 109)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	226	Target Neighborhood Hits	114	Shared Neighborhood Hits	80
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PLCG1_MOUSE
NC score	0.174991 (rank : 110)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	226	Target Neighborhood Hits	314	Shared Neighborhood Hits	119
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
NC score	0.174227 (rank : 111)	θ value	0.47712 (rank : 112)
Query Neighborhood Hits	226	Target Neighborhood Hits	280	Shared Neighborhood Hits	117
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV2_MOUSE
NC score	0.171505 (rank : 112)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	226	Target Neighborhood Hits	456	Shared Neighborhood Hits	127
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FNBP2_HUMAN
NC score	0.170509 (rank : 113)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	226	Target Neighborhood Hits	432	Shared Neighborhood Hits	120
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

VAV2_HUMAN
NC score	0.170220 (rank : 114)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	226	Target Neighborhood Hits	453	Shared Neighborhood Hits	126
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG9_HUMAN
NC score	0.168837 (rank : 115)	θ value	0.62314 (rank : 115)
Query Neighborhood Hits	226	Target Neighborhood Hits	235	Shared Neighborhood Hits	116
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.167849 (rank : 116)	θ value	0.62314 (rank : 116)
Query Neighborhood Hits	226	Target Neighborhood Hits	234	Shared Neighborhood Hits	116
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PLCG1_HUMAN
NC score	0.163183 (rank : 117)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	115
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ARHG4_HUMAN
NC score	0.158348 (rank : 118)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	226	Target Neighborhood Hits	242	Shared Neighborhood Hits	117
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

VAV3_HUMAN
NC score	0.157297 (rank : 119)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	226	Target Neighborhood Hits	398	Shared Neighborhood Hits	128
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ASPP1_MOUSE
NC score	0.155574 (rank : 120)	θ value	1.38821 (rank : 139)
Query Neighborhood Hits	226	Target Neighborhood Hits	1244	Shared Neighborhood Hits	151
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SPTA1_HUMAN
NC score	0.155550 (rank : 121)	θ value	0.00509761 (rank : 26)
Query Neighborhood Hits	226	Target Neighborhood Hits	748	Shared Neighborhood Hits	129
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ES8L3_MOUSE
NC score	0.155514 (rank : 122)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	226	Target Neighborhood Hits	168	Shared Neighborhood Hits	104
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ASPP1_HUMAN
NC score	0.154752 (rank : 123)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	226	Target Neighborhood Hits	956	Shared Neighborhood Hits	138
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

VAV3_MOUSE
NC score	0.153541 (rank : 124)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	226	Target Neighborhood Hits	404	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SPTA2_HUMAN
NC score	0.151031 (rank : 125)	θ value	0.125558 (rank : 72)
Query Neighborhood Hits	226	Target Neighborhood Hits	888	Shared Neighborhood Hits	133
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

DDEF2_MOUSE
NC score	0.150622 (rank : 126)	θ value	0.21417 (rank : 84)
Query Neighborhood Hits	226	Target Neighborhood Hits	625	Shared Neighborhood Hits	124
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
NC score	0.148638 (rank : 127)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	226	Target Neighborhood Hits	592	Shared Neighborhood Hits	117
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
NC score	0.146974 (rank : 128)	θ value	0.21417 (rank : 83)
Query Neighborhood Hits	226	Target Neighborhood Hits	599	Shared Neighborhood Hits	128
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPTA1_MOUSE
NC score	0.141196 (rank : 129)	θ value	0.279714 (rank : 97)
Query Neighborhood Hits	226	Target Neighborhood Hits	675	Shared Neighborhood Hits	121
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ES8L3_HUMAN
NC score	0.140619 (rank : 130)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	226	Target Neighborhood Hits	206	Shared Neighborhood Hits	94
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RIMB2_HUMAN
NC score	0.140335 (rank : 131)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	226	Target Neighborhood Hits	263	Shared Neighborhood Hits	92
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L2_HUMAN
NC score	0.139310 (rank : 132)	θ value	1.81305 (rank : 149)
Query Neighborhood Hits	226	Target Neighborhood Hits	193	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

RIMB2_MOUSE
NC score	0.139232 (rank : 133)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	226	Target Neighborhood Hits	246	Shared Neighborhood Hits	84
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ES8L2_MOUSE
NC score	0.138269 (rank : 134)	θ value	1.38821 (rank : 142)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	92
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NOXO1_HUMAN
NC score	0.133331 (rank : 135)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	226	Target Neighborhood Hits	100	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

RHG26_HUMAN
NC score	0.130943 (rank : 136)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	226	Target Neighborhood Hits	281	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

MYO1F_HUMAN
NC score	0.128983 (rank : 137)	θ value	0.0736092 (rank : 63)
Query Neighborhood Hits	226	Target Neighborhood Hits	275	Shared Neighborhood Hits	135
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

TCGAP_MOUSE
NC score	0.127583 (rank : 138)	θ value	1.38821 (rank : 147)
Query Neighborhood Hits	226	Target Neighborhood Hits	409	Shared Neighborhood Hits	102
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MYO1F_MOUSE
NC score	0.126811 (rank : 139)	θ value	0.279714 (rank : 92)
Query Neighborhood Hits	226	Target Neighborhood Hits	262	Shared Neighborhood Hits	130
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SPN90_HUMAN
NC score	0.126334 (rank : 140)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SLAP2_HUMAN
NC score	0.118488 (rank : 141)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	226	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

TCGAP_HUMAN
NC score	0.117889 (rank : 142)	θ value	1.81305 (rank : 152)
Query Neighborhood Hits	226	Target Neighborhood Hits	872	Shared Neighborhood Hits	115
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SLAP2_MOUSE
NC score	0.117874 (rank : 143)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	226	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ES8L1_MOUSE
NC score	0.113675 (rank : 144)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	226	Target Neighborhood Hits	143	Shared Neighborhood Hits	73
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MYO1E_HUMAN
NC score	0.113323 (rank : 145)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	226	Target Neighborhood Hits	293	Shared Neighborhood Hits	131
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SPN90_MOUSE
NC score	0.113016 (rank : 146)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ES8L1_HUMAN
NC score	0.112999 (rank : 147)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	226	Target Neighborhood Hits	162	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EPS8_MOUSE
NC score	0.111884 (rank : 148)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	226	Target Neighborhood Hits	157	Shared Neighborhood Hits	91
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ASPP2_HUMAN
NC score	0.111364 (rank : 149)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	226	Target Neighborhood Hits	1156	Shared Neighborhood Hits	120
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ARHG4_MOUSE
NC score	0.110775 (rank : 150)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

SLAP1_HUMAN
NC score	0.108419 (rank : 151)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	226	Target Neighborhood Hits	113	Shared Neighborhood Hits	35
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

CIP4_HUMAN
NC score	0.107562 (rank : 152)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	226	Target Neighborhood Hits	374	Shared Neighborhood Hits	64
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SLAP1_MOUSE
NC score	0.107188 (rank : 153)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	226	Target Neighborhood Hits	117	Shared Neighborhood Hits	35
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

FYN_MOUSE
NC score	0.105284 (rank : 154)	θ value	0.47712 (rank : 105)
Query Neighborhood Hits	226	Target Neighborhood Hits	1073	Shared Neighborhood Hits	137
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

EPS8_HUMAN
NC score	0.104429 (rank : 155)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	80
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SNX9_HUMAN
NC score	0.103711 (rank : 156)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	226	Target Neighborhood Hits	148	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

FYN_HUMAN
NC score	0.103510 (rank : 157)	θ value	0.47712 (rank : 104)
Query Neighborhood Hits	226	Target Neighborhood Hits	1078	Shared Neighborhood Hits	137
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_HUMAN
NC score	0.102979 (rank : 158)	θ value	0.0252991 (rank : 47)
Query Neighborhood Hits	226	Target Neighborhood Hits	1067	Shared Neighborhood Hits	129
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
NC score	0.101825 (rank : 159)	θ value	0.0113563 (rank : 36)
Query Neighborhood Hits	226	Target Neighborhood Hits	1069	Shared Neighborhood Hits	132
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_MOUSE
NC score	0.100992 (rank : 160)	θ value	0.21417 (rank : 88)
Query Neighborhood Hits	226	Target Neighborhood Hits	1052	Shared Neighborhood Hits	132
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_HUMAN
NC score	0.100675 (rank : 161)	θ value	0.21417 (rank : 87)
Query Neighborhood Hits	226	Target Neighborhood Hits	1059	Shared Neighborhood Hits	132
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BTK_HUMAN
NC score	0.099646 (rank : 162)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	226	Target Neighborhood Hits	1026	Shared Neighborhood Hits	128
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SRC_HUMAN
NC score	0.098522 (rank : 163)	θ value	0.62314 (rank : 121)
Query Neighborhood Hits	226	Target Neighborhood Hits	1058	Shared Neighborhood Hits	136
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BTK_MOUSE
NC score	0.096572 (rank : 164)	θ value	0.00020696 (rank : 12)
Query Neighborhood Hits	226	Target Neighborhood Hits	1017	Shared Neighborhood Hits	120
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

AMPH_HUMAN
NC score	0.095264 (rank : 165)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	226	Target Neighborhood Hits	455	Shared Neighborhood Hits	73
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

P85A_MOUSE
NC score	0.094879 (rank : 166)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	226	Target Neighborhood Hits	435	Shared Neighborhood Hits	85
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX9_MOUSE
NC score	0.091753 (rank : 167)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	226	Target Neighborhood Hits	141	Shared Neighborhood Hits	66
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

P85A_HUMAN
NC score	0.090523 (rank : 168)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	226	Target Neighborhood Hits	479	Shared Neighborhood Hits	81
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RIMB1_HUMAN
NC score	0.090151 (rank : 169)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	226	Target Neighborhood Hits	1479	Shared Neighborhood Hits	125
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RASA1_HUMAN
NC score	0.089783 (rank : 170)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	226	Target Neighborhood Hits	258	Shared Neighborhood Hits	49
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

STS2_HUMAN
NC score	0.089538 (rank : 171)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	226	Target Neighborhood Hits	108	Shared Neighborhood Hits	59
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RIMB1_MOUSE
NC score	0.088473 (rank : 172)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	226	Target Neighborhood Hits	1376	Shared Neighborhood Hits	126
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRC_MOUSE
NC score	0.087781 (rank : 173)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	226	Target Neighborhood Hits	1033	Shared Neighborhood Hits	117
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_HUMAN
NC score	0.087473 (rank : 174)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	226	Target Neighborhood Hits	1035	Shared Neighborhood Hits	130
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
NC score	0.086108 (rank : 175)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	226	Target Neighborhood Hits	1029	Shared Neighborhood Hits	128
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

M3KL4_HUMAN
NC score	0.086082 (rank : 176)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	226	Target Neighborhood Hits	1087	Shared Neighborhood Hits	137
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

FRK_HUMAN
NC score	0.084664 (rank : 177)	θ value	0.163984 (rank : 74)
Query Neighborhood Hits	226	Target Neighborhood Hits	1058	Shared Neighborhood Hits	132
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LYN_MOUSE
NC score	0.081402 (rank : 178)	θ value	1.81305 (rank : 150)
Query Neighborhood Hits	226	Target Neighborhood Hits	1023	Shared Neighborhood Hits	114
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ARHG5_HUMAN
NC score	0.081034 (rank : 179)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	226	Target Neighborhood Hits	172	Shared Neighborhood Hits	58
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.080312 (rank : 180)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	226	Target Neighborhood Hits	166	Shared Neighborhood Hits	58
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BLK_HUMAN
NC score	0.080167 (rank : 181)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	226	Target Neighborhood Hits	994	Shared Neighborhood Hits	101
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_HUMAN
NC score	0.079994 (rank : 182)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	226	Target Neighborhood Hits	1022	Shared Neighborhood Hits	116
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BLK_MOUSE
NC score	0.079420 (rank : 183)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	226	Target Neighborhood Hits	992	Shared Neighborhood Hits	94
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

NGEF_MOUSE
NC score	0.078913 (rank : 184)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	56
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

M3K11_HUMAN
NC score	0.078108 (rank : 185)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	226	Target Neighborhood Hits	1136	Shared Neighborhood Hits	143
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SH21B_MOUSE
NC score	0.077548 (rank : 186)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PPIP2_HUMAN
NC score	0.076985 (rank : 187)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	226	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

BIN1_HUMAN
NC score	0.076214 (rank : 188)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	226	Target Neighborhood Hits	335	Shared Neighborhood Hits	64
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

TXK_MOUSE
NC score	0.075951 (rank : 189)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	226	Target Neighborhood Hits	980	Shared Neighborhood Hits	108
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TEC_MOUSE
NC score	0.075816 (rank : 190)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	226	Target Neighborhood Hits	1006	Shared Neighborhood Hits	106
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH21B_HUMAN
NC score	0.075493 (rank : 191)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	226	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TEC_HUMAN
NC score	0.075443 (rank : 192)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	226	Target Neighborhood Hits	1006	Shared Neighborhood Hits	103
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

P85B_HUMAN
NC score	0.074714 (rank : 193)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	226	Target Neighborhood Hits	543	Shared Neighborhood Hits	64
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SHAN2_MOUSE
NC score	0.073302 (rank : 194)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	226	Target Neighborhood Hits	446	Shared Neighborhood Hits	89
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

AMPH_MOUSE
NC score	0.073106 (rank : 195)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	226	Target Neighborhood Hits	291	Shared Neighborhood Hits	65
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

STS1_HUMAN
NC score	0.072944 (rank : 196)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	226	Target Neighborhood Hits	106	Shared Neighborhood Hits	53
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

PPIP2_MOUSE
NC score	0.072439 (rank : 197)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	226	Target Neighborhood Hits	308	Shared Neighborhood Hits	15
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

LCK_HUMAN
NC score	0.071886 (rank : 198)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	226	Target Neighborhood Hits	987	Shared Neighborhood Hits	86
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

STS1_MOUSE
NC score	0.071856 (rank : 199)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	226	Target Neighborhood Hits	104	Shared Neighborhood Hits	54
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

P85B_MOUSE
NC score	0.070853 (rank : 200)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	226	Target Neighborhood Hits	519	Shared Neighborhood Hits	61
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

LCK_MOUSE
NC score	0.070655 (rank : 201)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	226	Target Neighborhood Hits	981	Shared Neighborhood Hits	85
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

ITK_HUMAN
NC score	0.070311 (rank : 202)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	226	Target Neighborhood Hits	1016	Shared Neighborhood Hits	104
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

M3K9_HUMAN
NC score	0.070147 (rank : 203)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	226	Target Neighborhood Hits	1123	Shared Neighborhood Hits	133
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

BIN1_MOUSE
NC score	0.069520 (rank : 204)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	226	Target Neighborhood Hits	283	Shared Neighborhood Hits	61
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

SHAN1_HUMAN
NC score	0.069039 (rank : 205)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	226	Target Neighborhood Hits	1041	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

DOCK1_HUMAN
NC score	0.068997 (rank : 206)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	226	Target Neighborhood Hits	191	Shared Neighborhood Hits	82
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PTK6_MOUSE
NC score	0.068925 (rank : 207)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	226	Target Neighborhood Hits	1026	Shared Neighborhood Hits	116
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ARHGG_MOUSE
NC score	0.068803 (rank : 208)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	40
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

PTK6_HUMAN
NC score	0.068344 (rank : 209)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	226	Target Neighborhood Hits	1020	Shared Neighborhood Hits	116
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ABL1_MOUSE
NC score	0.068300 (rank : 210)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	226	Target Neighborhood Hits	1178	Shared Neighborhood Hits	103
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TXK_HUMAN
NC score	0.068205 (rank : 211)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	226	Target Neighborhood Hits	971	Shared Neighborhood Hits	96
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CSK_MOUSE
NC score	0.067743 (rank : 212)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	226	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.067667 (rank : 213)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	226	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ABL1_HUMAN
NC score	0.067540 (rank : 214)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	226	Target Neighborhood Hits	1220	Shared Neighborhood Hits	103
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

M3K10_HUMAN
NC score	0.066910 (rank : 215)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	226	Target Neighborhood Hits	1071	Shared Neighborhood Hits	123
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MPP5_HUMAN
NC score	0.066667 (rank : 216)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	226	Target Neighborhood Hits	231	Shared Neighborhood Hits	62
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.066185 (rank : 217)	θ value	2.36792 (rank : 158)
Query Neighborhood Hits	226	Target Neighborhood Hits	226	Shared Neighborhood Hits	61
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

ITK_MOUSE
NC score	0.065793 (rank : 218)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	226	Target Neighborhood Hits	985	Shared Neighborhood Hits	94
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SLY_MOUSE
NC score	0.065683 (rank : 219)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	226	Target Neighborhood Hits	108	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

DAPP1_MOUSE
NC score	0.065229 (rank : 220)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	226	Target Neighborhood Hits	225	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ABL2_HUMAN
NC score	0.064585 (rank : 221)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	226	Target Neighborhood Hits	1045	Shared Neighborhood Hits	86
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

DAPP1_HUMAN
NC score	0.063634 (rank : 222)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	226	Target Neighborhood Hits	227	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NSD1_MOUSE
NC score	0.063576 (rank : 223)	θ value	0.000786445 (rank : 15)
Query Neighborhood Hits	226	Target Neighborhood Hits	472	Shared Neighborhood Hits	18
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

K0310_HUMAN
NC score	0.062796 (rank : 224)	θ value	0.279714 (rank : 91)
Query Neighborhood Hits	226	Target Neighborhood Hits	420	Shared Neighborhood Hits	30
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

SRMS_MOUSE
NC score	0.061509 (rank : 225)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	226	Target Neighborhood Hits	964	Shared Neighborhood Hits	80
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

MATK_HUMAN
NC score	0.061437 (rank : 226)	θ value	0.0563607 (rank : 57)
Query Neighborhood Hits	226	Target Neighborhood Hits	954	Shared Neighborhood Hits	60
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

RFIP1_MOUSE
NC score	0.060637 (rank : 227)	θ value	0.47712 (rank : 114)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

P55G_HUMAN
NC score	0.060356 (rank : 228)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	226	Target Neighborhood Hits	451	Shared Neighborhood Hits	41
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

MPP6_HUMAN
NC score	0.060276 (rank : 229)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	226	Target Neighborhood Hits	180	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

P55G_MOUSE
NC score	0.060167 (rank : 230)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	226	Target Neighborhood Hits	401	Shared Neighborhood Hits	40
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SHE_MOUSE
NC score	0.059749 (rank : 231)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PNMT_HUMAN
NC score	0.059183 (rank : 232)	θ value	0.0961366 (rank : 68)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	P11086	Gene names	PNMT, PENT
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

SHC1_HUMAN
NC score	0.058523 (rank : 233)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	226	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

TAF4_HUMAN
NC score	0.058519 (rank : 234)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	226	Target Neighborhood Hits	687	Shared Neighborhood Hits	45
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

ARHGG_HUMAN
NC score	0.058474 (rank : 235)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	226	Target Neighborhood Hits	129	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SH21A_MOUSE
NC score	0.058288 (rank : 236)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	226	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SHE_HUMAN
NC score	0.058191 (rank : 237)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	226	Target Neighborhood Hits	164	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MPP6_MOUSE
NC score	0.057984 (rank : 238)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	226	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

APS_HUMAN
NC score	0.057982 (rank : 239)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	226	Target Neighborhood Hits	162	Shared Neighborhood Hits	35
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRB14_HUMAN
NC score	0.057852 (rank : 240)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	226	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

JIP2_HUMAN
NC score	0.057272 (rank : 241)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	226	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SHC3_MOUSE
NC score	0.057012 (rank : 242)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	34
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SH21A_HUMAN
NC score	0.057000 (rank : 243)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	226	Target Neighborhood Hits	89	Shared Neighborhood Hits	26
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

EM55_HUMAN
NC score	0.056881 (rank : 244)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	226	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

LNK_HUMAN
NC score	0.056848 (rank : 245)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	226	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

GRB14_MOUSE
NC score	0.056697 (rank : 246)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	226	Target Neighborhood Hits	149	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SHC1_MOUSE
NC score	0.056645 (rank : 247)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	226	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_HUMAN
NC score	0.055471 (rank : 248)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	226	Target Neighborhood Hits	155	Shared Neighborhood Hits	35
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SRMS_HUMAN
NC score	0.055245 (rank : 249)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	226	Target Neighborhood Hits	946	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

LCP2_MOUSE
NC score	0.054595 (rank : 250)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	226	Target Neighborhood Hits	177	Shared Neighborhood Hits	37
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

EM55_MOUSE
NC score	0.054485 (rank : 251)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	226	Target Neighborhood Hits	221	Shared Neighborhood Hits	66
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

SHC2_HUMAN
NC score	0.054113 (rank : 252)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	226	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

PNMT_MOUSE
NC score	0.053961 (rank : 253)	θ value	0.365318 (rank : 101)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P40935	Gene names	Pnmt
Domain Architecture
Description	Phenylethanolamine N-methyltransferase (EC 2.1.1.28) (PNMTase) (Noradrenaline N-methyltransferase).

SHC2_MOUSE
NC score	0.053605 (rank : 254)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	226	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

3BP1_HUMAN
NC score	0.053043 (rank : 255)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	226	Target Neighborhood Hits	376	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

LCP2_HUMAN
NC score	0.052385 (rank : 256)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	226	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MATK_MOUSE
NC score	0.052083 (rank : 257)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	226	Target Neighborhood Hits	952	Shared Neighborhood Hits	63
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

GPS2_HUMAN
NC score	0.051839 (rank : 258)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	226	Target Neighborhood Hits	459	Shared Neighborhood Hits	20
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

ARHG3_HUMAN
NC score	0.051661 (rank : 259)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	226	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

SHB_MOUSE
NC score	0.051278 (rank : 260)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	226	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

ARHG3_MOUSE
NC score	0.051017 (rank : 261)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	226	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

PRP2_MOUSE
NC score	0.050988 (rank : 262)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	226	Target Neighborhood Hits	347	Shared Neighborhood Hits	41
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

ARHG8_HUMAN
NC score	0.050534 (rank : 263)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	226	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

BI2L1_HUMAN
NC score	0.050388 (rank : 264)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	226	Target Neighborhood Hits	156	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ARHG8_MOUSE
NC score	0.050108 (rank : 265)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	226	Target Neighborhood Hits	79	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

BAIP2_MOUSE
NC score	0.050102 (rank : 266)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

CT151_HUMAN
NC score	0.049448 (rank : 267)	θ value	0.47712 (rank : 103)
Query Neighborhood Hits	226	Target Neighborhood Hits	382	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

GON4L_HUMAN
NC score	0.048861 (rank : 268)	θ value	0.0563607 (rank : 55)
Query Neighborhood Hits	226	Target Neighborhood Hits	555	Shared Neighborhood Hits	22
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MISS_MOUSE
NC score	0.048622 (rank : 269)	θ value	0.47712 (rank : 107)
Query Neighborhood Hits	226	Target Neighborhood Hits	444	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

OGFR_HUMAN
NC score	0.047746 (rank : 270)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	226	Target Neighborhood Hits	1582	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RM49_HUMAN
NC score	0.046591 (rank : 271)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q13405	Gene names	MRPL49, C11orf4, NOF1
Domain Architecture
Description	Mitochondrial 39S ribosomal protein L49 (L49mt) (MRP-L49) (Protein NOF1) (Neighbor of FAU) (NOF).

CTDP1_HUMAN
NC score	0.046194 (rank : 272)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	226	Target Neighborhood Hits	416	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DLG2_HUMAN
NC score	0.046148 (rank : 273)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	226	Target Neighborhood Hits	279	Shared Neighborhood Hits	62
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.045681 (rank : 274)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	63
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

CDSN_MOUSE
NC score	0.044642 (rank : 275)	θ value	1.38821 (rank : 140)
Query Neighborhood Hits	226	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

RGS3_MOUSE
NC score	0.044405 (rank : 276)	θ value	0.62314 (rank : 120)
Query Neighborhood Hits	226	Target Neighborhood Hits	1621	Shared Neighborhood Hits	71
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

PRRT3_HUMAN
NC score	0.042841 (rank : 277)	θ value	0.47712 (rank : 113)
Query Neighborhood Hits	226	Target Neighborhood Hits	998	Shared Neighborhood Hits	45
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

NACAM_MOUSE
NC score	0.042036 (rank : 278)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	226	Target Neighborhood Hits	1866	Shared Neighborhood Hits	80
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

DLG4_HUMAN
NC score	0.040167 (rank : 279)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	57
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

NRX2B_HUMAN
NC score	0.039651 (rank : 280)	θ value	0.62314 (rank : 118)
Query Neighborhood Hits	226	Target Neighborhood Hits	481	Shared Neighborhood Hits	22
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

EPHB3_MOUSE
NC score	0.038998 (rank : 281)	θ value	0.813845 (rank : 127)
Query Neighborhood Hits	226	Target Neighborhood Hits	996	Shared Neighborhood Hits	29
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

SRTD1_MOUSE
NC score	0.036293 (rank : 282)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	226	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JL10, Q925E6, Q9D888	Gene names	Sertad1, Sei1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

CO039_HUMAN
NC score	0.035999 (rank : 283)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	226	Target Neighborhood Hits	264	Shared Neighborhood Hits	27
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

EPHB3_HUMAN
NC score	0.035939 (rank : 284)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	226	Target Neighborhood Hits	996	Shared Neighborhood Hits	28
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

PSL1_HUMAN
NC score	0.035776 (rank : 285)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	226	Target Neighborhood Hits	650	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

MUC5B_HUMAN
NC score	0.033364 (rank : 286)	θ value	0.365318 (rank : 99)
Query Neighborhood Hits	226	Target Neighborhood Hits	1020	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

T22D4_HUMAN
NC score	0.032880 (rank : 287)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	226	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

GRIN1_HUMAN
NC score	0.032648 (rank : 288)	θ value	0.813845 (rank : 128)
Query Neighborhood Hits	226	Target Neighborhood Hits	681	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

LZTS2_MOUSE
NC score	0.032256 (rank : 289)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	226	Target Neighborhood Hits	423	Shared Neighborhood Hits	17
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

SON_HUMAN
NC score	0.031900 (rank : 290)	θ value	0.813845 (rank : 132)
Query Neighborhood Hits	226	Target Neighborhood Hits	1568	Shared Neighborhood Hits	54
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

BAT3_MOUSE
NC score	0.030349 (rank : 291)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	226	Target Neighborhood Hits	518	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

JPH2_HUMAN
NC score	0.030096 (rank : 292)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	226	Target Neighborhood Hits	639	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CJ119_HUMAN
NC score	0.029431 (rank : 293)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	226	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BTE3, Q6IA56, Q9BVT9, Q9H916	Gene names	C10orf119
Domain Architecture	No domain graphic available
Description	Protein C10orf119.

STAT6_HUMAN
NC score	0.029371 (rank : 294)	θ value	0.125558 (rank : 73)
Query Neighborhood Hits	226	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P42226	Gene names	STAT6
Domain Architecture
Description	Signal transducer and activator of transcription 6 (IL-4 Stat).

CIC_MOUSE
NC score	0.029350 (rank : 295)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	226	Target Neighborhood Hits	742	Shared Neighborhood Hits	48
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

MUC1_HUMAN
NC score	0.028904 (rank : 296)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	226	Target Neighborhood Hits	975	Shared Neighborhood Hits	45
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

CSKI1_HUMAN
NC score	0.028737 (rank : 297)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	226	Target Neighborhood Hits	997	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

AKAP1_MOUSE
NC score	0.028362 (rank : 298)	θ value	1.06291 (rank : 135)
Query Neighborhood Hits	226	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

MADCA_HUMAN
NC score	0.028219 (rank : 299)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	226	Target Neighborhood Hits	221	Shared Neighborhood Hits	23
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

GA2L1_MOUSE
NC score	0.028182 (rank : 300)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	226	Target Neighborhood Hits	114	Shared Neighborhood Hits	13
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

CJ119_MOUSE
NC score	0.027020 (rank : 301)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	226	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3C0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf119 homolog.

DOK7_MOUSE
NC score	0.026998 (rank : 302)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	226	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	Q18PE0, Q3TCZ6, Q5FW70, Q8C8U7	Gene names	Dok7
Domain Architecture	No domain graphic available
Description	Protein Dok-7 (Downstream of tyrosine kinase 7).

NRX2A_HUMAN
NC score	0.026842 (rank : 303)	θ value	0.62314 (rank : 117)
Query Neighborhood Hits	226	Target Neighborhood Hits	614	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

ZN541_HUMAN
NC score	0.024731 (rank : 304)	θ value	1.81305 (rank : 153)
Query Neighborhood Hits	226	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

CEL_HUMAN
NC score	0.023751 (rank : 305)	θ value	0.813845 (rank : 126)
Query Neighborhood Hits	226	Target Neighborhood Hits	896	Shared Neighborhood Hits	41
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

LZTS2_HUMAN
NC score	0.023479 (rank : 306)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	226	Target Neighborhood Hits	427	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

ZO2_HUMAN
NC score	0.022403 (rank : 307)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	226	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MBB1A_HUMAN
NC score	0.022256 (rank : 308)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	226	Target Neighborhood Hits	665	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

ZO2_MOUSE
NC score	0.021593 (rank : 309)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	226	Target Neighborhood Hits	296	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ULK1_MOUSE
NC score	0.021477 (rank : 310)	θ value	1.38821 (rank : 148)
Query Neighborhood Hits	226	Target Neighborhood Hits	1214	Shared Neighborhood Hits	53
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

TTC28_HUMAN
NC score	0.019898 (rank : 311)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	226	Target Neighborhood Hits	271	Shared Neighborhood Hits	11
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

DIDO1_HUMAN
NC score	0.019577 (rank : 312)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	226	Target Neighborhood Hits	960	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

HCN2_MOUSE
NC score	0.019220 (rank : 313)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	226	Target Neighborhood Hits	278	Shared Neighborhood Hits	27
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

BSCL2_MOUSE
NC score	0.018664 (rank : 314)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	226	Target Neighborhood Hits	94	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2E9, Q810B0, Q9JJC2, Q9JMF1	Gene names	Bscl2, Gng3lg
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog).

NEK1_MOUSE
NC score	0.017954 (rank : 315)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	226	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

ZIMP7_MOUSE
NC score	0.017527 (rank : 316)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	226	Target Neighborhood Hits	566	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

SPEG_MOUSE
NC score	0.017483 (rank : 317)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	226	Target Neighborhood Hits	1959	Shared Neighborhood Hits	71
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TDRKH_MOUSE
NC score	0.016539 (rank : 318)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	226	Target Neighborhood Hits	59	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VL1	Gene names	Tdrkh
Domain Architecture
Description	Tudor and KH domain-containing protein.

JHD3C_HUMAN
NC score	0.016209 (rank : 319)	θ value	0.813845 (rank : 129)
Query Neighborhood Hits	226	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H3R0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3	Gene names	JMJD2C, GASC1, JHDM3C, KIAA0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein).

TNC6B_HUMAN
NC score	0.015204 (rank : 320)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	226	Target Neighborhood Hits	256	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

MYOD1_HUMAN
NC score	0.014747 (rank : 321)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	226	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

GAK_MOUSE
NC score	0.014697 (rank : 322)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	226	Target Neighborhood Hits	964	Shared Neighborhood Hits	30
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KBTBB_MOUSE
NC score	0.013451 (rank : 323)	θ value	1.38821 (rank : 144)
Query Neighborhood Hits	226	Target Neighborhood Hits	184	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BNW9	Gene names	Kbtbd11, Kiaa0711
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 11.

SRCA_MOUSE
NC score	0.013446 (rank : 324)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	226	Target Neighborhood Hits	212	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TQ48, Q8BS43	Gene names	Srl, Sar
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

INVS_MOUSE
NC score	0.013350 (rank : 325)	θ value	1.38821 (rank : 143)
Query Neighborhood Hits	226	Target Neighborhood Hits	609	Shared Neighborhood Hits	24
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

TNNT2_HUMAN
NC score	0.013340 (rank : 326)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	226	Target Neighborhood Hits	433	Shared Neighborhood Hits	10
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

GEMI2_MOUSE
NC score	0.012681 (rank : 327)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	226	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQQ4, Q9DAD7	Gene names	Sip1, Gemin2
Domain Architecture	No domain graphic available
Description	Survival of motor neuron protein-interacting protein 1 (SMN- interacting protein 1) (Component of gems 2) (Gemin-2).

PVRL2_HUMAN
NC score	0.012246 (rank : 328)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	226	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

RPGF1_HUMAN
NC score	0.011808 (rank : 329)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	226	Target Neighborhood Hits	262	Shared Neighborhood Hits	14
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GR65_MOUSE
NC score	0.011385 (rank : 330)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	226	Target Neighborhood Hits	54	Shared Neighborhood Hits	2
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

GLI3_HUMAN
NC score	0.009674 (rank : 331)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	226	Target Neighborhood Hits	871	Shared Neighborhood Hits	13
SwissProt Accessions	P10071, O75219, Q9UDT5, Q9UJ39	Gene names	GLI3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI3.

MA1B1_HUMAN
NC score	0.009502 (rank : 332)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	226	Target Neighborhood Hits	125	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKM7, Q5VSG3, Q9BRS9, Q9Y5K7	Gene names	MAN1B1
Domain Architecture
Description	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase).

JHD2B_MOUSE
NC score	0.009245 (rank : 333)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	226	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

ZN447_HUMAN
NC score	0.008848 (rank : 334)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	226	Target Neighborhood Hits	899	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

DGKG_MOUSE
NC score	0.007497 (rank : 335)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	226	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

GLIS3_MOUSE
NC score	0.006893 (rank : 336)	θ value	0.47712 (rank : 106)
Query Neighborhood Hits	226	Target Neighborhood Hits	861	Shared Neighborhood Hits	19
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

SREC_HUMAN
NC score	0.006512 (rank : 337)	θ value	1.38821 (rank : 146)
Query Neighborhood Hits	226	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

GLIS3_HUMAN
NC score	0.006194 (rank : 338)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	226	Target Neighborhood Hits	758	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

SEM3B_MOUSE
NC score	0.005234 (rank : 339)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	226	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

SALL3_HUMAN
NC score	0.005113 (rank : 340)	θ value	1.81305 (rank : 151)
Query Neighborhood Hits	226	Target Neighborhood Hits	1066	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

FOXL1_MOUSE
NC score	0.003833 (rank : 341)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	226	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

GP124_HUMAN
NC score	0.003608 (rank : 342)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	226	Target Neighborhood Hits	304	Shared Neighborhood Hits	3
SwissProt Accessions	Q96PE1, Q8N3R1, Q8TEM3, Q96KB2, Q9P1Z7, Q9UFY4	Gene names	GPR124, KIAA1531, TEM5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

ADAM8_MOUSE
NC score	0.003067 (rank : 343)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	226	Target Neighborhood Hits	326	Shared Neighborhood Hits	10
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

PRGR_MOUSE
NC score	0.002581 (rank : 344)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	226	Target Neighborhood Hits	286	Shared Neighborhood Hits	10
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

ZN516_MOUSE
NC score	0.001751 (rank : 345)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	226	Target Neighborhood Hits	1197	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

VLDLR_HUMAN
NC score	0.001472 (rank : 346)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	226	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).