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Network neighborhood for query Sequence : NCF4_HUMAN

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NCF4_HUMAN
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NCF4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	161	Target Neighborhood Hits	161	Shared Neighborhood Hits	161
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	3.47952e-169 (rank : 2)	NC score	0.985656 (rank : 2)
Query Neighborhood Hits	161	Target Neighborhood Hits	177	Shared Neighborhood Hits	152
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SH3G1_MOUSE
θ value	4.76016e-09 (rank : 3)	NC score	0.609028 (rank : 8)
Query Neighborhood Hits	161	Target Neighborhood Hits	291	Shared Neighborhood Hits	130
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G1_HUMAN
θ value	6.21693e-09 (rank : 4)	NC score	0.602514 (rank : 11)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

NCF1_MOUSE
θ value	8.11959e-09 (rank : 5)	NC score	0.568329 (rank : 20)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SH3G2_HUMAN
θ value	1.38499e-08 (rank : 6)	NC score	0.608694 (rank : 9)
Query Neighborhood Hits	161	Target Neighborhood Hits	324	Shared Neighborhood Hits	130
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NCF1_HUMAN
θ value	2.36244e-08 (rank : 7)	NC score	0.577128 (rank : 18)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3G3_HUMAN
θ value	2.36244e-08 (rank : 8)	NC score	0.620678 (rank : 6)
Query Neighborhood Hits	161	Target Neighborhood Hits	222	Shared Neighborhood Hits	130
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	4.0297e-08 (rank : 9)	NC score	0.617328 (rank : 7)
Query Neighborhood Hits	161	Target Neighborhood Hits	236	Shared Neighborhood Hits	130
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VINEX_MOUSE
θ value	5.26297e-08 (rank : 10)	NC score	0.626928 (rank : 4)
Query Neighborhood Hits	161	Target Neighborhood Hits	286	Shared Neighborhood Hits	135
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

NCF2_HUMAN
θ value	1.17247e-07 (rank : 11)	NC score	0.649167 (rank : 3)
Query Neighborhood Hits	161	Target Neighborhood Hits	229	Shared Neighborhood Hits	122
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3G2_MOUSE
θ value	1.17247e-07 (rank : 12)	NC score	0.604371 (rank : 10)
Query Neighborhood Hits	161	Target Neighborhood Hits	319	Shared Neighborhood Hits	131
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

ITSN1_HUMAN
θ value	2.61198e-07 (rank : 13)	NC score	0.372478 (rank : 81)
Query Neighborhood Hits	161	Target Neighborhood Hits	1757	Shared Neighborhood Hits	136
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VINEX_HUMAN
θ value	5.81887e-07 (rank : 14)	NC score	0.623387 (rank : 5)
Query Neighborhood Hits	161	Target Neighborhood Hits	270	Shared Neighborhood Hits	131
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ITSN2_HUMAN
θ value	9.92553e-07 (rank : 15)	NC score	0.402309 (rank : 67)
Query Neighborhood Hits	161	Target Neighborhood Hits	1173	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DNMBP_HUMAN
θ value	1.29631e-06 (rank : 16)	NC score	0.505745 (rank : 29)
Query Neighborhood Hits	161	Target Neighborhood Hits	413	Shared Neighborhood Hits	133
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRBS1_MOUSE
θ value	1.29631e-06 (rank : 17)	NC score	0.594566 (rank : 13)
Query Neighborhood Hits	161	Target Neighborhood Hits	409	Shared Neighborhood Hits	131
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ABI2_HUMAN
θ value	1.69304e-06 (rank : 18)	NC score	0.565748 (rank : 21)
Query Neighborhood Hits	161	Target Neighborhood Hits	350	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	2.21117e-06 (rank : 19)	NC score	0.572695 (rank : 19)
Query Neighborhood Hits	161	Target Neighborhood Hits	266	Shared Neighborhood Hits	126
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARHG4_HUMAN
θ value	2.21117e-06 (rank : 20)	NC score	0.414082 (rank : 60)
Query Neighborhood Hits	161	Target Neighborhood Hits	242	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

DNMBP_MOUSE
θ value	2.88788e-06 (rank : 21)	NC score	0.500830 (rank : 33)
Query Neighborhood Hits	161	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ITSN2_MOUSE
θ value	2.88788e-06 (rank : 22)	NC score	0.380975 (rank : 77)
Query Neighborhood Hits	161	Target Neighborhood Hits	1371	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
θ value	4.92598e-06 (rank : 23)	NC score	0.370485 (rank : 82)
Query Neighborhood Hits	161	Target Neighborhood Hits	1669	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SRBS1_HUMAN
θ value	4.92598e-06 (rank : 24)	NC score	0.587255 (rank : 17)
Query Neighborhood Hits	161	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_MOUSE
θ value	8.40245e-06 (rank : 25)	NC score	0.595079 (rank : 12)
Query Neighborhood Hits	161	Target Neighborhood Hits	336	Shared Neighborhood Hits	131
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ARHG9_HUMAN
θ value	1.43324e-05 (rank : 26)	NC score	0.411886 (rank : 62)
Query Neighborhood Hits	161	Target Neighborhood Hits	235	Shared Neighborhood Hits	123
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	1.43324e-05 (rank : 27)	NC score	0.411112 (rank : 63)
Query Neighborhood Hits	161	Target Neighborhood Hits	234	Shared Neighborhood Hits	123
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

STAM2_MOUSE
θ value	3.19293e-05 (rank : 28)	NC score	0.501029 (rank : 32)
Query Neighborhood Hits	161	Target Neighborhood Hits	285	Shared Neighborhood Hits	130
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CD2AP_HUMAN
θ value	4.1701e-05 (rank : 29)	NC score	0.592009 (rank : 14)
Query Neighborhood Hits	161	Target Neighborhood Hits	315	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
θ value	5.44631e-05 (rank : 30)	NC score	0.591296 (rank : 15)
Query Neighborhood Hits	161	Target Neighborhood Hits	341	Shared Neighborhood Hits	127
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	5.44631e-05 (rank : 31)	NC score	0.589420 (rank : 16)
Query Neighborhood Hits	161	Target Neighborhood Hits	332	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SPTA1_HUMAN
θ value	5.44631e-05 (rank : 32)	NC score	0.240069 (rank : 121)
Query Neighborhood Hits	161	Target Neighborhood Hits	748	Shared Neighborhood Hits	126
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRGP2_MOUSE
θ value	9.29e-05 (rank : 33)	NC score	0.327629 (rank : 95)
Query Neighborhood Hits	161	Target Neighborhood Hits	324	Shared Neighborhood Hits	113
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP1_HUMAN
θ value	0.000121331 (rank : 34)	NC score	0.314072 (rank : 100)
Query Neighborhood Hits	161	Target Neighborhood Hits	390	Shared Neighborhood Hits	110
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	0.000121331 (rank : 35)	NC score	0.322473 (rank : 98)
Query Neighborhood Hits	161	Target Neighborhood Hits	331	Shared Neighborhood Hits	112
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

STAC_HUMAN
θ value	0.000121331 (rank : 36)	NC score	0.519255 (rank : 26)
Query Neighborhood Hits	161	Target Neighborhood Hits	276	Shared Neighborhood Hits	123
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

HCLS1_MOUSE
θ value	0.000158464 (rank : 37)	NC score	0.547347 (rank : 23)
Query Neighborhood Hits	161	Target Neighborhood Hits	329	Shared Neighborhood Hits	127
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ABI1_MOUSE
θ value	0.000270298 (rank : 38)	NC score	0.558237 (rank : 22)
Query Neighborhood Hits	161	Target Neighborhood Hits	246	Shared Neighborhood Hits	125
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HCLS1_HUMAN
θ value	0.000270298 (rank : 39)	NC score	0.545811 (rank : 24)
Query Neighborhood Hits	161	Target Neighborhood Hits	358	Shared Neighborhood Hits	131
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP_HUMAN
θ value	0.00035302 (rank : 40)	NC score	0.430392 (rank : 47)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	0.00035302 (rank : 41)	NC score	0.461620 (rank : 41)
Query Neighborhood Hits	161	Target Neighborhood Hits	310	Shared Neighborhood Hits	131
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00035302 (rank : 42)	NC score	0.460877 (rank : 42)
Query Neighborhood Hits	161	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

AHI1_HUMAN
θ value	0.000461057 (rank : 43)	NC score	0.357408 (rank : 84)
Query Neighborhood Hits	161	Target Neighborhood Hits	537	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

STAM2_HUMAN
θ value	0.000461057 (rank : 44)	NC score	0.488231 (rank : 38)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	127
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SPTA1_MOUSE
θ value	0.000602161 (rank : 45)	NC score	0.240386 (rank : 120)
Query Neighborhood Hits	161	Target Neighborhood Hits	675	Shared Neighborhood Hits	121
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	0.000602161 (rank : 46)	NC score	0.241480 (rank : 119)
Query Neighborhood Hits	161	Target Neighborhood Hits	888	Shared Neighborhood Hits	130
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ARHG4_MOUSE
θ value	0.000786445 (rank : 47)	NC score	0.354418 (rank : 87)
Query Neighborhood Hits	161	Target Neighborhood Hits	185	Shared Neighborhood Hits	94
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FNBP2_HUMAN
θ value	0.000786445 (rank : 48)	NC score	0.303422 (rank : 105)
Query Neighborhood Hits	161	Target Neighborhood Hits	432	Shared Neighborhood Hits	111
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

STAM1_HUMAN
θ value	0.000786445 (rank : 49)	NC score	0.502960 (rank : 30)
Query Neighborhood Hits	161	Target Neighborhood Hits	271	Shared Neighborhood Hits	128
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.000786445 (rank : 50)	NC score	0.502491 (rank : 31)
Query Neighborhood Hits	161	Target Neighborhood Hits	273	Shared Neighborhood Hits	128
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG7_HUMAN
θ value	0.00102713 (rank : 51)	NC score	0.480337 (rank : 39)
Query Neighborhood Hits	161	Target Neighborhood Hits	347	Shared Neighborhood Hits	128
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

RHG04_HUMAN
θ value	0.00102713 (rank : 52)	NC score	0.339620 (rank : 94)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	117
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

STAC_MOUSE
θ value	0.00102713 (rank : 53)	NC score	0.494976 (rank : 35)
Query Neighborhood Hits	161	Target Neighborhood Hits	268	Shared Neighborhood Hits	121
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI1_HUMAN
θ value	0.00175202 (rank : 54)	NC score	0.536147 (rank : 25)
Query Neighborhood Hits	161	Target Neighborhood Hits	257	Shared Neighborhood Hits	124
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

GRAP2_MOUSE
θ value	0.00175202 (rank : 55)	NC score	0.456004 (rank : 44)
Query Neighborhood Hits	161	Target Neighborhood Hits	297	Shared Neighborhood Hits	131
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

MYO1F_MOUSE
θ value	0.00175202 (rank : 56)	NC score	0.228944 (rank : 125)
Query Neighborhood Hits	161	Target Neighborhood Hits	262	Shared Neighborhood Hits	125
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
θ value	0.00228821 (rank : 57)	NC score	0.228723 (rank : 127)
Query Neighborhood Hits	161	Target Neighborhood Hits	275	Shared Neighborhood Hits	125
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SNX18_MOUSE
θ value	0.00228821 (rank : 58)	NC score	0.403537 (rank : 66)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

AHI1_MOUSE
θ value	0.00298849 (rank : 59)	NC score	0.357365 (rank : 85)
Query Neighborhood Hits	161	Target Neighborhood Hits	496	Shared Neighborhood Hits	131
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

GRAP_MOUSE
θ value	0.00298849 (rank : 60)	NC score	0.424272 (rank : 52)
Query Neighborhood Hits	161	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

OSTF1_HUMAN
θ value	0.00298849 (rank : 61)	NC score	0.404089 (rank : 65)
Query Neighborhood Hits	161	Target Neighborhood Hits	466	Shared Neighborhood Hits	128
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	0.00298849 (rank : 62)	NC score	0.394944 (rank : 73)
Query Neighborhood Hits	161	Target Neighborhood Hits	467	Shared Neighborhood Hits	129
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ARHG7_MOUSE
θ value	0.00390308 (rank : 63)	NC score	0.490292 (rank : 37)
Query Neighborhood Hits	161	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DDEF1_MOUSE
θ value	0.00509761 (rank : 64)	NC score	0.272148 (rank : 108)
Query Neighborhood Hits	161	Target Neighborhood Hits	592	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

EFS_MOUSE
θ value	0.00509761 (rank : 65)	NC score	0.372518 (rank : 80)
Query Neighborhood Hits	161	Target Neighborhood Hits	389	Shared Neighborhood Hits	114
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

MYO1E_HUMAN
θ value	0.00509761 (rank : 66)	NC score	0.218427 (rank : 130)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	125
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SNX18_HUMAN
θ value	0.00509761 (rank : 67)	NC score	0.396978 (rank : 71)
Query Neighborhood Hits	161	Target Neighborhood Hits	207	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ARHG6_HUMAN
θ value	0.00665767 (rank : 68)	NC score	0.458387 (rank : 43)
Query Neighborhood Hits	161	Target Neighborhood Hits	376	Shared Neighborhood Hits	126
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	0.00665767 (rank : 69)	NC score	0.464399 (rank : 40)
Query Neighborhood Hits	161	Target Neighborhood Hits	394	Shared Neighborhood Hits	127
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

DDEF2_HUMAN
θ value	0.00665767 (rank : 70)	NC score	0.250217 (rank : 116)
Query Neighborhood Hits	161	Target Neighborhood Hits	599	Shared Neighborhood Hits	114
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP2_HUMAN
θ value	0.00665767 (rank : 71)	NC score	0.443950 (rank : 45)
Query Neighborhood Hits	161	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SGK3_HUMAN
θ value	0.00665767 (rank : 72)	NC score	0.024415 (rank : 330)
Query Neighborhood Hits	161	Target Neighborhood Hits	877	Shared Neighborhood Hits	38
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

EFS_HUMAN
θ value	0.00869519 (rank : 73)	NC score	0.365587 (rank : 83)
Query Neighborhood Hits	161	Target Neighborhood Hits	348	Shared Neighborhood Hits	114
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NEBU_HUMAN
θ value	0.00869519 (rank : 74)	NC score	0.351465 (rank : 88)
Query Neighborhood Hits	161	Target Neighborhood Hits	420	Shared Neighborhood Hits	125
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

VAV_HUMAN
θ value	0.00869519 (rank : 75)	NC score	0.373445 (rank : 79)
Query Neighborhood Hits	161	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

LASP1_HUMAN
θ value	0.0113563 (rank : 76)	NC score	0.429327 (rank : 48)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.0113563 (rank : 77)	NC score	0.427786 (rank : 50)
Query Neighborhood Hits	161	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

DDEF2_MOUSE
θ value	0.0148317 (rank : 78)	NC score	0.251404 (rank : 115)
Query Neighborhood Hits	161	Target Neighborhood Hits	625	Shared Neighborhood Hits	111
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

VAV_MOUSE
θ value	0.0148317 (rank : 79)	NC score	0.375117 (rank : 78)
Query Neighborhood Hits	161	Target Neighborhood Hits	430	Shared Neighborhood Hits	130
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

NEBL_HUMAN
θ value	0.0193708 (rank : 80)	NC score	0.385558 (rank : 75)
Query Neighborhood Hits	161	Target Neighborhood Hits	457	Shared Neighborhood Hits	123
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SGK3_MOUSE
θ value	0.0193708 (rank : 81)	NC score	0.023725 (rank : 332)
Query Neighborhood Hits	161	Target Neighborhood Hits	882	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

CRK_HUMAN
θ value	0.0252991 (rank : 82)	NC score	0.414211 (rank : 59)
Query Neighborhood Hits	161	Target Neighborhood Hits	308	Shared Neighborhood Hits	128
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SNX24_MOUSE
θ value	0.0252991 (rank : 83)	NC score	0.153313 (rank : 153)
Query Neighborhood Hits	161	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

SRC8_HUMAN
θ value	0.0252991 (rank : 84)	NC score	0.513596 (rank : 27)
Query Neighborhood Hits	161	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

BI2L1_MOUSE
θ value	0.0330416 (rank : 85)	NC score	0.189123 (rank : 137)
Query Neighborhood Hits	161	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CRKL_HUMAN
θ value	0.0330416 (rank : 86)	NC score	0.415571 (rank : 58)
Query Neighborhood Hits	161	Target Neighborhood Hits	313	Shared Neighborhood Hits	128
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
θ value	0.0330416 (rank : 87)	NC score	0.421023 (rank : 56)
Query Neighborhood Hits	161	Target Neighborhood Hits	314	Shared Neighborhood Hits	128
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCK1_HUMAN
θ value	0.0330416 (rank : 88)	NC score	0.407397 (rank : 64)
Query Neighborhood Hits	161	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SNX22_HUMAN
θ value	0.0330416 (rank : 89)	NC score	0.160543 (rank : 148)
Query Neighborhood Hits	161	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

SRC8_MOUSE
θ value	0.0330416 (rank : 90)	NC score	0.511074 (rank : 28)
Query Neighborhood Hits	161	Target Neighborhood Hits	292	Shared Neighborhood Hits	127
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

BI2L1_HUMAN
θ value	0.0431538 (rank : 91)	NC score	0.210443 (rank : 133)
Query Neighborhood Hits	161	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PACN1_HUMAN
θ value	0.0431538 (rank : 92)	NC score	0.422178 (rank : 54)
Query Neighborhood Hits	161	Target Neighborhood Hits	320	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	0.0431538 (rank : 93)	NC score	0.422359 (rank : 53)
Query Neighborhood Hits	161	Target Neighborhood Hits	283	Shared Neighborhood Hits	127
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

VAV2_HUMAN
θ value	0.0431538 (rank : 94)	NC score	0.350214 (rank : 90)
Query Neighborhood Hits	161	Target Neighborhood Hits	453	Shared Neighborhood Hits	127
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.0431538 (rank : 95)	NC score	0.351246 (rank : 89)
Query Neighborhood Hits	161	Target Neighborhood Hits	456	Shared Neighborhood Hits	127
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ABI3_MOUSE
θ value	0.0563607 (rank : 96)	NC score	0.491730 (rank : 36)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ANM2_MOUSE
θ value	0.0563607 (rank : 97)	NC score	0.254930 (rank : 113)
Query Neighborhood Hits	161	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CRKL_MOUSE
θ value	0.0563607 (rank : 98)	NC score	0.400914 (rank : 68)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	123
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

P3C2B_HUMAN
θ value	0.0563607 (rank : 99)	NC score	0.063844 (rank : 281)
Query Neighborhood Hits	161	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PACN3_HUMAN
θ value	0.0563607 (rank : 100)	NC score	0.395702 (rank : 72)
Query Neighborhood Hits	161	Target Neighborhood Hits	385	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	0.0563607 (rank : 101)	NC score	0.397028 (rank : 70)
Query Neighborhood Hits	161	Target Neighborhood Hits	380	Shared Neighborhood Hits	124
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SNX24_HUMAN
θ value	0.0563607 (rank : 102)	NC score	0.145973 (rank : 161)
Query Neighborhood Hits	161	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

ABI3_HUMAN
θ value	0.0736092 (rank : 103)	NC score	0.496518 (rank : 34)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PACN2_HUMAN
θ value	0.0736092 (rank : 104)	NC score	0.433096 (rank : 46)
Query Neighborhood Hits	161	Target Neighborhood Hits	339	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PEX13_HUMAN
θ value	0.0736092 (rank : 105)	NC score	0.344487 (rank : 92)
Query Neighborhood Hits	161	Target Neighborhood Hits	128	Shared Neighborhood Hits	90
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

RUSC1_MOUSE
θ value	0.0736092 (rank : 106)	NC score	0.306330 (rank : 103)
Query Neighborhood Hits	161	Target Neighborhood Hits	206	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SNX2_HUMAN
θ value	0.0736092 (rank : 107)	NC score	0.096438 (rank : 213)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	O60749, O43650, P82862, Q53XK8, Q597H6, Q9BTS8	Gene names	SNX2, TRG9
Domain Architecture
Description	Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9).

SNX2_MOUSE
θ value	0.0736092 (rank : 108)	NC score	0.095917 (rank : 216)
Query Neighborhood Hits	161	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CWK8, Q3UKW3, Q9CQV0	Gene names	Snx2
Domain Architecture
Description	Sorting nexin-2.

M3K11_HUMAN
θ value	0.0961366 (rank : 109)	NC score	0.105994 (rank : 200)
Query Neighborhood Hits	161	Target Neighborhood Hits	1136	Shared Neighborhood Hits	120
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PACN2_MOUSE
θ value	0.0961366 (rank : 110)	NC score	0.428721 (rank : 49)
Query Neighborhood Hits	161	Target Neighborhood Hits	382	Shared Neighborhood Hits	131
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RHG26_HUMAN
θ value	0.0961366 (rank : 111)	NC score	0.254774 (rank : 114)
Query Neighborhood Hits	161	Target Neighborhood Hits	281	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

PEX13_MOUSE
θ value	0.125558 (rank : 112)	NC score	0.346838 (rank : 91)
Query Neighborhood Hits	161	Target Neighborhood Hits	126	Shared Neighborhood Hits	92
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

P3C2A_MOUSE
θ value	0.163984 (rank : 113)	NC score	0.047560 (rank : 327)
Query Neighborhood Hits	161	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

SNX19_HUMAN
θ value	0.163984 (rank : 114)	NC score	0.096198 (rank : 215)
Query Neighborhood Hits	161	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

SNX20_MOUSE
θ value	0.163984 (rank : 115)	NC score	0.131893 (rank : 172)
Query Neighborhood Hits	161	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2Y5, Q544B6	Gene names	Snx20
Domain Architecture	No domain graphic available
Description	Sorting nexin-20.

STAC3_HUMAN
θ value	0.279714 (rank : 116)	NC score	0.413271 (rank : 61)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	113
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

RUSC1_HUMAN
θ value	0.365318 (rank : 117)	NC score	0.309821 (rank : 102)
Query Neighborhood Hits	161	Target Neighborhood Hits	226	Shared Neighborhood Hits	103
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STAC3_MOUSE
θ value	0.365318 (rank : 118)	NC score	0.415646 (rank : 57)
Query Neighborhood Hits	161	Target Neighborhood Hits	232	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV3_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.323546 (rank : 97)
Query Neighborhood Hits	161	Target Neighborhood Hits	398	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SNX14_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.101985 (rank : 202)
Query Neighborhood Hits	161	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

BCAR1_MOUSE
θ value	0.62314 (rank : 121)	NC score	0.327024 (rank : 96)
Query Neighborhood Hits	161	Target Neighborhood Hits	438	Shared Neighborhood Hits	122
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SNX7_HUMAN
θ value	0.62314 (rank : 122)	NC score	0.096424 (rank : 214)
Query Neighborhood Hits	161	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UNH6, Q86U82, Q8WVD4, Q96FW9, Q9Y3Z7	Gene names	SNX7
Domain Architecture
Description	Sorting nexin-7.

ANM2_HUMAN
θ value	0.813845 (rank : 123)	NC score	0.258606 (rank : 110)
Query Neighborhood Hits	161	Target Neighborhood Hits	175	Shared Neighborhood Hits	110
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SNX13_HUMAN
θ value	0.813845 (rank : 124)	NC score	0.071812 (rank : 263)
Query Neighborhood Hits	161	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

SNX8_HUMAN
θ value	0.813845 (rank : 125)	NC score	0.101448 (rank : 204)
Query Neighborhood Hits	161	Target Neighborhood Hits	66	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

SNX14_MOUSE
θ value	1.06291 (rank : 126)	NC score	0.098075 (rank : 210)
Query Neighborhood Hits	161	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

M3K9_HUMAN
θ value	1.38821 (rank : 127)	NC score	0.100018 (rank : 206)
Query Neighborhood Hits	161	Target Neighborhood Hits	1123	Shared Neighborhood Hits	123
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

BCAR1_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.317700 (rank : 99)
Query Neighborhood Hits	161	Target Neighborhood Hits	554	Shared Neighborhood Hits	124
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

RUSC2_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.146038 (rank : 160)
Query Neighborhood Hits	161	Target Neighborhood Hits	205	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SNX13_MOUSE
θ value	1.81305 (rank : 130)	NC score	0.070042 (rank : 268)
Query Neighborhood Hits	161	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

CASL_MOUSE
θ value	2.36792 (rank : 131)	NC score	0.305881 (rank : 104)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	114
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

ES8L3_MOUSE
θ value	2.36792 (rank : 132)	NC score	0.207247 (rank : 135)
Query Neighborhood Hits	161	Target Neighborhood Hits	168	Shared Neighborhood Hits	101
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

M3KL4_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.114409 (rank : 190)
Query Neighborhood Hits	161	Target Neighborhood Hits	1087	Shared Neighborhood Hits	121
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PPIP1_HUMAN
θ value	2.36792 (rank : 134)	NC score	0.425499 (rank : 51)
Query Neighborhood Hits	161	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	2.36792 (rank : 135)	NC score	0.421926 (rank : 55)
Query Neighborhood Hits	161	Target Neighborhood Hits	377	Shared Neighborhood Hits	127
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RUSC2_MOUSE
θ value	2.36792 (rank : 136)	NC score	0.130007 (rank : 174)
Query Neighborhood Hits	161	Target Neighborhood Hits	305	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SNX16_MOUSE
θ value	2.36792 (rank : 137)	NC score	0.120458 (rank : 183)
Query Neighborhood Hits	161	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

RS10_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.023951 (rank : 331)
Query Neighborhood Hits	161	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P63325, P09900, Q9DCR5	Gene names	Rps10
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S10.

SNX16_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.116157 (rank : 189)
Query Neighborhood Hits	161	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

SRC_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.098488 (rank : 208)
Query Neighborhood Hits	161	Target Neighborhood Hits	1058	Shared Neighborhood Hits	127
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRMS_MOUSE
θ value	3.0926 (rank : 141)	NC score	0.036483 (rank : 329)
Query Neighborhood Hits	161	Target Neighborhood Hits	964	Shared Neighborhood Hits	70
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BAIP2_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.174429 (rank : 143)
Query Neighborhood Hits	161	Target Neighborhood Hits	192	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	4.03905 (rank : 143)	NC score	0.177000 (rank : 142)
Query Neighborhood Hits	161	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

DOCK2_HUMAN
θ value	4.03905 (rank : 144)	NC score	0.055399 (rank : 305)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	35
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

FGR_HUMAN
θ value	4.03905 (rank : 145)	NC score	0.098231 (rank : 209)
Query Neighborhood Hits	161	Target Neighborhood Hits	1067	Shared Neighborhood Hits	123
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NPHP1_MOUSE
θ value	4.03905 (rank : 146)	NC score	0.354895 (rank : 86)
Query Neighborhood Hits	161	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SNX7_MOUSE
θ value	4.03905 (rank : 147)	NC score	0.086358 (rank : 235)
Query Neighborhood Hits	161	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CY18	Gene names	Snx7
Domain Architecture
Description	Sorting nexin-7.

FYN_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.099769 (rank : 207)
Query Neighborhood Hits	161	Target Neighborhood Hits	1078	Shared Neighborhood Hits	127
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.101551 (rank : 203)
Query Neighborhood Hits	161	Target Neighborhood Hits	1073	Shared Neighborhood Hits	127
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

P3C2A_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.043109 (rank : 328)
Query Neighborhood Hits	161	Target Neighborhood Hits	188	Shared Neighborhood Hits	15
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

SNX11_HUMAN
θ value	5.27518 (rank : 151)	NC score	0.069505 (rank : 269)
Query Neighborhood Hits	161	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5W9, Q9H885	Gene names	SNX11
Domain Architecture
Description	Sorting nexin-11.

SNX27_HUMAN
θ value	5.27518 (rank : 152)	NC score	0.054379 (rank : 307)
Query Neighborhood Hits	161	Target Neighborhood Hits	54	Shared Neighborhood Hits	17
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

DOCK2_MOUSE
θ value	6.88961 (rank : 153)	NC score	0.053289 (rank : 313)
Query Neighborhood Hits	161	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

HERPU_MOUSE
θ value	6.88961 (rank : 154)	NC score	0.014613 (rank : 333)
Query Neighborhood Hits	161	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJK5	Gene names	Herpud1
Domain Architecture
Description	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein.

PTK6_HUMAN
θ value	6.88961 (rank : 155)	NC score	0.058474 (rank : 292)
Query Neighborhood Hits	161	Target Neighborhood Hits	1020	Shared Neighborhood Hits	112
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

YES_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.096920 (rank : 212)
Query Neighborhood Hits	161	Target Neighborhood Hits	1052	Shared Neighborhood Hits	123
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CASL_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.301488 (rank : 106)
Query Neighborhood Hits	161	Target Neighborhood Hits	259	Shared Neighborhood Hits	114
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DBNL_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.398469 (rank : 69)
Query Neighborhood Hits	161	Target Neighborhood Hits	244	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.392590 (rank : 74)
Query Neighborhood Hits	161	Target Neighborhood Hits	306	Shared Neighborhood Hits	116
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

FRK_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.074296 (rank : 254)
Query Neighborhood Hits	161	Target Neighborhood Hits	1058	Shared Neighborhood Hits	124
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

YES_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.095141 (rank : 218)
Query Neighborhood Hits	161	Target Neighborhood Hits	1059	Shared Neighborhood Hits	123
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

3BP1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.068421 (rank : 272)
Query Neighborhood Hits	161	Target Neighborhood Hits	376	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABR_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.093072 (rank : 221)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	23
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AMPH_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.123922 (rank : 179)
Query Neighborhood Hits	161	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.108630 (rank : 196)
Query Neighborhood Hits	161	Target Neighborhood Hits	291	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

APS_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.054358 (rank : 308)
Query Neighborhood Hits	161	Target Neighborhood Hits	162	Shared Neighborhood Hits	26
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.100712 (rank : 205)
Query Neighborhood Hits	161	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.073914 (rank : 257)
Query Neighborhood Hits	161	Target Neighborhood Hits	266	Shared Neighborhood Hits	11
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.086885 (rank : 234)
Query Neighborhood Hits	161	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.089398 (rank : 229)
Query Neighborhood Hits	161	Target Neighborhood Hits	120	Shared Neighborhood Hits	19
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.146449 (rank : 158)
Query Neighborhood Hits	161	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.146386 (rank : 159)
Query Neighborhood Hits	161	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.208219 (rank : 134)
Query Neighborhood Hits	161	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.134604 (rank : 169)
Query Neighborhood Hits	161	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.142648 (rank : 163)
Query Neighborhood Hits	161	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.119603 (rank : 185)
Query Neighborhood Hits	161	Target Neighborhood Hits	187	Shared Neighborhood Hits	19
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.126282 (rank : 177)
Query Neighborhood Hits	161	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.097011 (rank : 211)
Query Neighborhood Hits	161	Target Neighborhood Hits	375	Shared Neighborhood Hits	17
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.095316 (rank : 217)
Query Neighborhood Hits	161	Target Neighborhood Hits	351	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.094773 (rank : 219)
Query Neighborhood Hits	161	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.090493 (rank : 227)
Query Neighborhood Hits	161	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.138703 (rank : 167)
Query Neighborhood Hits	161	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.153731 (rank : 152)
Query Neighborhood Hits	161	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP1_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.182909 (rank : 139)
Query Neighborhood Hits	161	Target Neighborhood Hits	956	Shared Neighborhood Hits	120
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.183426 (rank : 138)
Query Neighborhood Hits	161	Target Neighborhood Hits	1244	Shared Neighborhood Hits	119
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.150570 (rank : 155)
Query Neighborhood Hits	161	Target Neighborhood Hits	1156	Shared Neighborhood Hits	105
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BCR_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.106339 (rank : 199)
Query Neighborhood Hits	161	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BIN1_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.113582 (rank : 191)
Query Neighborhood Hits	161	Target Neighborhood Hits	335	Shared Neighborhood Hits	54
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.109628 (rank : 195)
Query Neighborhood Hits	161	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.058381 (rank : 293)
Query Neighborhood Hits	161	Target Neighborhood Hits	994	Shared Neighborhood Hits	96
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.055780 (rank : 304)
Query Neighborhood Hits	161	Target Neighborhood Hits	992	Shared Neighborhood Hits	86
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BTK_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.083543 (rank : 237)
Query Neighborhood Hits	161	Target Neighborhood Hits	1026	Shared Neighborhood Hits	124
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.077519 (rank : 245)
Query Neighborhood Hits	161	Target Neighborhood Hits	1017	Shared Neighborhood Hits	118
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CHIN_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.072807 (rank : 262)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.074049 (rank : 256)
Query Neighborhood Hits	161	Target Neighborhood Hits	229	Shared Neighborhood Hits	35
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.073691 (rank : 259)
Query Neighborhood Hits	161	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.057477 (rank : 298)
Query Neighborhood Hits	161	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CIP4_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.118485 (rank : 187)
Query Neighborhood Hits	161	Target Neighborhood Hits	374	Shared Neighborhood Hits	51
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSK_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.059082 (rank : 291)
Query Neighborhood Hits	161	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.059308 (rank : 290)
Query Neighborhood Hits	161	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.340395 (rank : 93)
Query Neighborhood Hits	161	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAPP1_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.051971 (rank : 318)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.053631 (rank : 310)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DOCK1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.122274 (rank : 181)
Query Neighborhood Hits	161	Target Neighborhood Hits	191	Shared Neighborhood Hits	89
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

ECT2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.106878 (rank : 197)
Query Neighborhood Hits	161	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.110438 (rank : 194)
Query Neighborhood Hits	161	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.092839 (rank : 222)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.088729 (rank : 231)
Query Neighborhood Hits	161	Target Neighborhood Hits	221	Shared Neighborhood Hits	71
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EPS8_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.139023 (rank : 166)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.142455 (rank : 164)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.119107 (rank : 186)
Query Neighborhood Hits	161	Target Neighborhood Hits	162	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.126731 (rank : 176)
Query Neighborhood Hits	161	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.136070 (rank : 168)
Query Neighborhood Hits	161	Target Neighborhood Hits	193	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 214)	NC score	0.129874 (rank : 175)
Query Neighborhood Hits	161	Target Neighborhood Hits	169	Shared Neighborhood Hits	82
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.167936 (rank : 146)
Query Neighborhood Hits	161	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FARP1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.075171 (rank : 250)
Query Neighborhood Hits	161	Target Neighborhood Hits	241	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.073900 (rank : 258)
Query Neighborhood Hits	161	Target Neighborhood Hits	240	Shared Neighborhood Hits	17
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.080076 (rank : 241)
Query Neighborhood Hits	161	Target Neighborhood Hits	209	Shared Neighborhood Hits	20
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD1_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.076769 (rank : 246)
Query Neighborhood Hits	161	Target Neighborhood Hits	367	Shared Neighborhood Hits	21
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.076092 (rank : 248)
Query Neighborhood Hits	161	Target Neighborhood Hits	387	Shared Neighborhood Hits	18
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.089154 (rank : 230)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.084309 (rank : 236)
Query Neighborhood Hits	161	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.087659 (rank : 233)
Query Neighborhood Hits	161	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.093417 (rank : 220)
Query Neighborhood Hits	161	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.091174 (rank : 224)
Query Neighborhood Hits	161	Target Neighborhood Hits	219	Shared Neighborhood Hits	21
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.091008 (rank : 225)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.067393 (rank : 273)
Query Neighborhood Hits	161	Target Neighborhood Hits	237	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.070945 (rank : 267)
Query Neighborhood Hits	161	Target Neighborhood Hits	282	Shared Neighborhood Hits	19
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGR_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.089871 (rank : 228)
Query Neighborhood Hits	161	Target Neighborhood Hits	1069	Shared Neighborhood Hits	125
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FUT8_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.066958 (rank : 274)
Query Neighborhood Hits	161	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.063337 (rank : 283)
Query Neighborhood Hits	161	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GNRP_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.073274 (rank : 260)
Query Neighborhood Hits	161	Target Neighborhood Hits	239	Shared Neighborhood Hits	17
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.090502 (rank : 226)
Query Neighborhood Hits	161	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.110627 (rank : 193)
Query Neighborhood Hits	161	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HCK_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.074793 (rank : 252)
Query Neighborhood Hits	161	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.074876 (rank : 251)
Query Neighborhood Hits	161	Target Neighborhood Hits	1029	Shared Neighborhood Hits	124
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

IASPP_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.200309 (rank : 136)
Query Neighborhood Hits	161	Target Neighborhood Hits	688	Shared Neighborhood Hits	116
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.182211 (rank : 140)
Query Neighborhood Hits	161	Target Neighborhood Hits	1024	Shared Neighborhood Hits	117
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

JIP1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.071264 (rank : 266)
Query Neighborhood Hits	161	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.071310 (rank : 265)
Query Neighborhood Hits	161	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.076147 (rank : 247)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.078949 (rank : 244)
Query Neighborhood Hits	161	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LBC_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.092698 (rank : 223)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.050608 (rank : 322)
Query Neighborhood Hits	161	Target Neighborhood Hits	987	Shared Neighborhood Hits	75
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.050271 (rank : 325)
Query Neighborhood Hits	161	Target Neighborhood Hits	981	Shared Neighborhood Hits	74
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LYN_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.066480 (rank : 275)
Query Neighborhood Hits	161	Target Neighborhood Hits	1022	Shared Neighborhood Hits	113
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.064859 (rank : 279)
Query Neighborhood Hits	161	Target Neighborhood Hits	1023	Shared Neighborhood Hits	111
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K10_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.082986 (rank : 238)
Query Neighborhood Hits	161	Target Neighborhood Hits	1071	Shared Neighborhood Hits	111
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MCF2L_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.151695 (rank : 154)
Query Neighborhood Hits	161	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.131014 (rank : 173)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	22
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MPP5_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.056266 (rank : 300)
Query Neighborhood Hits	161	Target Neighborhood Hits	231	Shared Neighborhood Hits	54
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.055298 (rank : 306)
Query Neighborhood Hits	161	Target Neighborhood Hits	226	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.065748 (rank : 277)
Query Neighborhood Hits	161	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.062203 (rank : 285)
Query Neighborhood Hits	161	Target Neighborhood Hits	187	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NCK2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.382810 (rank : 76)
Query Neighborhood Hits	161	Target Neighborhood Hits	310	Shared Neighborhood Hits	127
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NGEF_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.172011 (rank : 144)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.169672 (rank : 145)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.210965 (rank : 132)
Query Neighborhood Hits	161	Target Neighborhood Hits	100	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.265713 (rank : 109)
Query Neighborhood Hits	161	Target Neighborhood Hits	114	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.296193 (rank : 107)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	109
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

OPHN1_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.061185 (rank : 287)
Query Neighborhood Hits	161	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.057806 (rank : 296)
Query Neighborhood Hits	161	Target Neighborhood Hits	174	Shared Neighborhood Hits	12
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

P85A_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.106548 (rank : 198)
Query Neighborhood Hits	161	Target Neighborhood Hits	479	Shared Neighborhood Hits	74
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.116383 (rank : 188)
Query Neighborhood Hits	161	Target Neighborhood Hits	435	Shared Neighborhood Hits	79
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.080331 (rank : 240)
Query Neighborhood Hits	161	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.074098 (rank : 255)
Query Neighborhood Hits	161	Target Neighborhood Hits	519	Shared Neighborhood Hits	51
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHG1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.157548 (rank : 150)
Query Neighborhood Hits	161	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.081326 (rank : 239)
Query Neighborhood Hits	161	Target Neighborhood Hits	200	Shared Neighborhood Hits	16
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.228814 (rank : 126)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	111
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.243741 (rank : 117)
Query Neighborhood Hits	161	Target Neighborhood Hits	314	Shared Neighborhood Hits	115
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.233496 (rank : 124)
Query Neighborhood Hits	161	Target Neighborhood Hits	280	Shared Neighborhood Hits	111
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.053513 (rank : 311)
Query Neighborhood Hits	161	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PREX1_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.158351 (rank : 149)
Query Neighborhood Hits	161	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK6_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.057974 (rank : 295)
Query Neighborhood Hits	161	Target Neighborhood Hits	1026	Shared Neighborhood Hits	109
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RASA1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.071478 (rank : 264)
Query Neighborhood Hits	161	Target Neighborhood Hits	258	Shared Neighborhood Hits	39
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

REPS2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.055875 (rank : 303)
Query Neighborhood Hits	161	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.056057 (rank : 301)
Query Neighborhood Hits	161	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.087680 (rank : 232)
Query Neighborhood Hits	161	Target Neighborhood Hits	641	Shared Neighborhood Hits	26
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG09_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.076006 (rank : 249)
Query Neighborhood Hits	161	Target Neighborhood Hits	186	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.060552 (rank : 288)
Query Neighborhood Hits	161	Target Neighborhood Hits	190	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.065255 (rank : 278)
Query Neighborhood Hits	161	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RIMB1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.125963 (rank : 178)
Query Neighborhood Hits	161	Target Neighborhood Hits	1479	Shared Neighborhood Hits	104
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.123437 (rank : 180)
Query Neighborhood Hits	161	Target Neighborhood Hits	1376	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.243385 (rank : 118)
Query Neighborhood Hits	161	Target Neighborhood Hits	263	Shared Neighborhood Hits	93
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.235146 (rank : 123)
Query Neighborhood Hits	161	Target Neighborhood Hits	246	Shared Neighborhood Hits	83
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SAMN1_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.063713 (rank : 282)
Query Neighborhood Hits	161	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.061374 (rank : 286)
Query Neighborhood Hits	161	Target Neighborhood Hits	69	Shared Neighborhood Hits	34
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.068675 (rank : 271)
Query Neighborhood Hits	161	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.063970 (rank : 280)
Query Neighborhood Hits	161	Target Neighborhood Hits	263	Shared Neighborhood Hits	45
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21B_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.052544 (rank : 316)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	19
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.051067 (rank : 321)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.111440 (rank : 192)
Query Neighborhood Hits	161	Target Neighborhood Hits	1041	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.147084 (rank : 157)
Query Neighborhood Hits	161	Target Neighborhood Hits	446	Shared Neighborhood Hits	83
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.052594 (rank : 314)
Query Neighborhood Hits	161	Target Neighborhood Hits	137	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC3_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.053364 (rank : 312)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHE_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.050350 (rank : 324)
Query Neighborhood Hits	161	Target Neighborhood Hits	169	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHLB1_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.255433 (rank : 112)
Query Neighborhood Hits	161	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.257765 (rank : 111)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB2_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.221856 (rank : 129)
Query Neighborhood Hits	161	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.223529 (rank : 128)
Query Neighborhood Hits	161	Target Neighborhood Hits	88	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.058138 (rank : 294)
Query Neighborhood Hits	161	Target Neighborhood Hits	113	Shared Neighborhood Hits	23
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.055920 (rank : 302)
Query Neighborhood Hits	161	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.079447 (rank : 243)
Query Neighborhood Hits	161	Target Neighborhood Hits	139	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.074298 (rank : 253)
Query Neighborhood Hits	161	Target Neighborhood Hits	136	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.104514 (rank : 201)
Query Neighborhood Hits	161	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.121896 (rank : 182)
Query Neighborhood Hits	161	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX11_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.062456 (rank : 284)
Query Neighborhood Hits	161	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WL6, Q3V3A6	Gene names	Snx11
Domain Architecture	No domain graphic available
Description	Sorting nexin-11.

SNX1_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.066345 (rank : 276)
Query Neighborhood Hits	161	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

SNX1_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.068732 (rank : 270)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

SNX25_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.050560 (rank : 323)
Query Neighborhood Hits	161	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

SNX4_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.050237 (rank : 326)
Query Neighborhood Hits	161	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	O95219	Gene names	SNX4
Domain Architecture
Description	Sorting nexin-4.

SNX4_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.051915 (rank : 319)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q91YJ2	Gene names	Snx4
Domain Architecture	No domain graphic available
Description	Sorting nexin-4.

SNX8_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.079724 (rank : 242)
Query Neighborhood Hits	161	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFD4, Q8BLI6, Q8BUQ7	Gene names	Snx8
Domain Architecture	No domain graphic available
Description	Sorting nexin-8.

SNX9_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.235638 (rank : 122)
Query Neighborhood Hits	161	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.212695 (rank : 131)
Query Neighborhood Hits	161	Target Neighborhood Hits	141	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

SOS1_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.057736 (rank : 297)
Query Neighborhood Hits	161	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.056716 (rank : 299)
Query Neighborhood Hits	161	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.141826 (rank : 165)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.119720 (rank : 184)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.073197 (rank : 261)
Query Neighborhood Hits	161	Target Neighborhood Hits	1033	Shared Neighborhood Hits	114
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

STS1_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.134584 (rank : 170)
Query Neighborhood Hits	161	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 322)	NC score	0.132920 (rank : 171)
Query Neighborhood Hits	161	Target Neighborhood Hits	104	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.153817 (rank : 151)
Query Neighborhood Hits	161	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.164057 (rank : 147)
Query Neighborhood Hits	161	Target Neighborhood Hits	872	Shared Neighborhood Hits	101
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.180825 (rank : 141)
Query Neighborhood Hits	161	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEC_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.053948 (rank : 309)
Query Neighborhood Hits	161	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TEC_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.052568 (rank : 315)
Query Neighborhood Hits	161	Target Neighborhood Hits	1006	Shared Neighborhood Hits	97
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TIAM1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.144584 (rank : 162)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.147459 (rank : 156)
Query Neighborhood Hits	161	Target Neighborhood Hits	205	Shared Neighborhood Hits	20
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRIO_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.051328 (rank : 320)
Query Neighborhood Hits	161	Target Neighborhood Hits	1580	Shared Neighborhood Hits	52
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TXK_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.052086 (rank : 317)
Query Neighborhood Hits	161	Target Neighborhood Hits	971	Shared Neighborhood Hits	85
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.059897 (rank : 289)
Query Neighborhood Hits	161	Target Neighborhood Hits	980	Shared Neighborhood Hits	96
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

VAV3_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.312411 (rank : 101)
Query Neighborhood Hits	161	Target Neighborhood Hits	404	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

Hits sorted by NC score

NCF4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	161	Target Neighborhood Hits	161	Shared Neighborhood Hits	161
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.985656 (rank : 2)	θ value	3.47952e-169 (rank : 2)
Query Neighborhood Hits	161	Target Neighborhood Hits	177	Shared Neighborhood Hits	152
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF2_HUMAN
NC score	0.649167 (rank : 3)	θ value	1.17247e-07 (rank : 11)
Query Neighborhood Hits	161	Target Neighborhood Hits	229	Shared Neighborhood Hits	122
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_MOUSE
NC score	0.626928 (rank : 4)	θ value	5.26297e-08 (rank : 10)
Query Neighborhood Hits	161	Target Neighborhood Hits	286	Shared Neighborhood Hits	135
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.623387 (rank : 5)	θ value	5.81887e-07 (rank : 14)
Query Neighborhood Hits	161	Target Neighborhood Hits	270	Shared Neighborhood Hits	131
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

SH3G3_HUMAN
NC score	0.620678 (rank : 6)	θ value	2.36244e-08 (rank : 8)
Query Neighborhood Hits	161	Target Neighborhood Hits	222	Shared Neighborhood Hits	130
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
NC score	0.617328 (rank : 7)	θ value	4.0297e-08 (rank : 9)
Query Neighborhood Hits	161	Target Neighborhood Hits	236	Shared Neighborhood Hits	130
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G1_MOUSE
NC score	0.609028 (rank : 8)	θ value	4.76016e-09 (rank : 3)
Query Neighborhood Hits	161	Target Neighborhood Hits	291	Shared Neighborhood Hits	130
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
NC score	0.608694 (rank : 9)	θ value	1.38499e-08 (rank : 6)
Query Neighborhood Hits	161	Target Neighborhood Hits	324	Shared Neighborhood Hits	130
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
NC score	0.604371 (rank : 10)	θ value	1.17247e-07 (rank : 12)
Query Neighborhood Hits	161	Target Neighborhood Hits	319	Shared Neighborhood Hits	131
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_HUMAN
NC score	0.602514 (rank : 11)	θ value	6.21693e-09 (rank : 4)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	129
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CD2AP_MOUSE
NC score	0.595079 (rank : 12)	θ value	8.40245e-06 (rank : 25)
Query Neighborhood Hits	161	Target Neighborhood Hits	336	Shared Neighborhood Hits	131
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRBS1_MOUSE
NC score	0.594566 (rank : 13)	θ value	1.29631e-06 (rank : 17)
Query Neighborhood Hits	161	Target Neighborhood Hits	409	Shared Neighborhood Hits	131
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CD2AP_HUMAN
NC score	0.592009 (rank : 14)	θ value	4.1701e-05 (rank : 29)
Query Neighborhood Hits	161	Target Neighborhood Hits	315	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.591296 (rank : 15)	θ value	5.44631e-05 (rank : 30)
Query Neighborhood Hits	161	Target Neighborhood Hits	341	Shared Neighborhood Hits	127
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.589420 (rank : 16)	θ value	5.44631e-05 (rank : 31)
Query Neighborhood Hits	161	Target Neighborhood Hits	332	Shared Neighborhood Hits	128
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SRBS1_HUMAN
NC score	0.587255 (rank : 17)	θ value	4.92598e-06 (rank : 24)
Query Neighborhood Hits	161	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF1_HUMAN
NC score	0.577128 (rank : 18)	θ value	2.36244e-08 (rank : 7)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	120
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ABI2_MOUSE
NC score	0.572695 (rank : 19)	θ value	2.21117e-06 (rank : 19)
Query Neighborhood Hits	161	Target Neighborhood Hits	266	Shared Neighborhood Hits	126
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF1_MOUSE
NC score	0.568329 (rank : 20)	θ value	8.11959e-09 (rank : 5)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	124
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ABI2_HUMAN
NC score	0.565748 (rank : 21)	θ value	1.69304e-06 (rank : 18)
Query Neighborhood Hits	161	Target Neighborhood Hits	350	Shared Neighborhood Hits	127
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI1_MOUSE
NC score	0.558237 (rank : 22)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	161	Target Neighborhood Hits	246	Shared Neighborhood Hits	125
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

HCLS1_MOUSE
NC score	0.547347 (rank : 23)	θ value	0.000158464 (rank : 37)
Query Neighborhood Hits	161	Target Neighborhood Hits	329	Shared Neighborhood Hits	127
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.545811 (rank : 24)	θ value	0.000270298 (rank : 39)
Query Neighborhood Hits	161	Target Neighborhood Hits	358	Shared Neighborhood Hits	131
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI1_HUMAN
NC score	0.536147 (rank : 25)	θ value	0.00175202 (rank : 54)
Query Neighborhood Hits	161	Target Neighborhood Hits	257	Shared Neighborhood Hits	124
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

STAC_HUMAN
NC score	0.519255 (rank : 26)	θ value	0.000121331 (rank : 36)
Query Neighborhood Hits	161	Target Neighborhood Hits	276	Shared Neighborhood Hits	123
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRC8_HUMAN
NC score	0.513596 (rank : 27)	θ value	0.0252991 (rank : 84)
Query Neighborhood Hits	161	Target Neighborhood Hits	269	Shared Neighborhood Hits	127
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.511074 (rank : 28)	θ value	0.0330416 (rank : 90)
Query Neighborhood Hits	161	Target Neighborhood Hits	292	Shared Neighborhood Hits	127
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DNMBP_HUMAN
NC score	0.505745 (rank : 29)	θ value	1.29631e-06 (rank : 16)
Query Neighborhood Hits	161	Target Neighborhood Hits	413	Shared Neighborhood Hits	133
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAM1_HUMAN
NC score	0.502960 (rank : 30)	θ value	0.000786445 (rank : 49)
Query Neighborhood Hits	161	Target Neighborhood Hits	271	Shared Neighborhood Hits	128
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.502491 (rank : 31)	θ value	0.000786445 (rank : 50)
Query Neighborhood Hits	161	Target Neighborhood Hits	273	Shared Neighborhood Hits	128
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.501029 (rank : 32)	θ value	3.19293e-05 (rank : 28)
Query Neighborhood Hits	161	Target Neighborhood Hits	285	Shared Neighborhood Hits	130
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

DNMBP_MOUSE
NC score	0.500830 (rank : 33)	θ value	2.88788e-06 (rank : 21)
Query Neighborhood Hits	161	Target Neighborhood Hits	435	Shared Neighborhood Hits	133
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ABI3_HUMAN
NC score	0.496518 (rank : 34)	θ value	0.0736092 (rank : 103)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	113
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC_MOUSE
NC score	0.494976 (rank : 35)	θ value	0.00102713 (rank : 53)
Query Neighborhood Hits	161	Target Neighborhood Hits	268	Shared Neighborhood Hits	121
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_MOUSE
NC score	0.491730 (rank : 36)	θ value	0.0563607 (rank : 96)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ARHG7_MOUSE
NC score	0.490292 (rank : 37)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	161	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

STAM2_HUMAN
NC score	0.488231 (rank : 38)	θ value	0.000461057 (rank : 44)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	127
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ARHG7_HUMAN
NC score	0.480337 (rank : 39)	θ value	0.00102713 (rank : 51)
Query Neighborhood Hits	161	Target Neighborhood Hits	347	Shared Neighborhood Hits	128
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_MOUSE
NC score	0.464399 (rank : 40)	θ value	0.00665767 (rank : 69)
Query Neighborhood Hits	161	Target Neighborhood Hits	394	Shared Neighborhood Hits	127
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

GRB2_HUMAN
NC score	0.461620 (rank : 41)	θ value	0.00035302 (rank : 41)
Query Neighborhood Hits	161	Target Neighborhood Hits	310	Shared Neighborhood Hits	131
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.460877 (rank : 42)	θ value	0.00035302 (rank : 42)
Query Neighborhood Hits	161	Target Neighborhood Hits	312	Shared Neighborhood Hits	131
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ARHG6_HUMAN
NC score	0.458387 (rank : 43)	θ value	0.00665767 (rank : 68)
Query Neighborhood Hits	161	Target Neighborhood Hits	376	Shared Neighborhood Hits	126
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

GRAP2_MOUSE
NC score	0.456004 (rank : 44)	θ value	0.00175202 (rank : 55)
Query Neighborhood Hits	161	Target Neighborhood Hits	297	Shared Neighborhood Hits	131
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP2_HUMAN
NC score	0.443950 (rank : 45)	θ value	0.00665767 (rank : 71)
Query Neighborhood Hits	161	Target Neighborhood Hits	304	Shared Neighborhood Hits	131
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PACN2_HUMAN
NC score	0.433096 (rank : 46)	θ value	0.0736092 (rank : 104)
Query Neighborhood Hits	161	Target Neighborhood Hits	339	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

GRAP_HUMAN
NC score	0.430392 (rank : 47)	θ value	0.00035302 (rank : 40)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	132
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

LASP1_HUMAN
NC score	0.429327 (rank : 48)	θ value	0.0113563 (rank : 76)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PACN2_MOUSE
NC score	0.428721 (rank : 49)	θ value	0.0961366 (rank : 110)
Query Neighborhood Hits	161	Target Neighborhood Hits	382	Shared Neighborhood Hits	131
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LASP1_MOUSE
NC score	0.427786 (rank : 50)	θ value	0.0113563 (rank : 77)
Query Neighborhood Hits	161	Target Neighborhood Hits	297	Shared Neighborhood Hits	121
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

PPIP1_HUMAN
NC score	0.425499 (rank : 51)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	161	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP_MOUSE
NC score	0.424272 (rank : 52)	θ value	0.00298849 (rank : 60)
Query Neighborhood Hits	161	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PACN1_MOUSE
NC score	0.422359 (rank : 53)	θ value	0.0431538 (rank : 93)
Query Neighborhood Hits	161	Target Neighborhood Hits	283	Shared Neighborhood Hits	127
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.422178 (rank : 54)	θ value	0.0431538 (rank : 92)
Query Neighborhood Hits	161	Target Neighborhood Hits	320	Shared Neighborhood Hits	126
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PPIP1_MOUSE
NC score	0.421926 (rank : 55)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	161	Target Neighborhood Hits	377	Shared Neighborhood Hits	127
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

CRK_MOUSE
NC score	0.421023 (rank : 56)	θ value	0.0330416 (rank : 87)
Query Neighborhood Hits	161	Target Neighborhood Hits	314	Shared Neighborhood Hits	128
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

STAC3_MOUSE
NC score	0.415646 (rank : 57)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	161	Target Neighborhood Hits	232	Shared Neighborhood Hits	113
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CRKL_HUMAN
NC score	0.415571 (rank : 58)	θ value	0.0330416 (rank : 86)
Query Neighborhood Hits	161	Target Neighborhood Hits	313	Shared Neighborhood Hits	128
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
NC score	0.414211 (rank : 59)	θ value	0.0252991 (rank : 82)
Query Neighborhood Hits	161	Target Neighborhood Hits	308	Shared Neighborhood Hits	128
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ARHG4_HUMAN
NC score	0.414082 (rank : 60)	θ value	2.21117e-06 (rank : 20)
Query Neighborhood Hits	161	Target Neighborhood Hits	242	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

STAC3_HUMAN
NC score	0.413271 (rank : 61)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	113
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG9_HUMAN
NC score	0.411886 (rank : 62)	θ value	1.43324e-05 (rank : 26)
Query Neighborhood Hits	161	Target Neighborhood Hits	235	Shared Neighborhood Hits	123
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.411112 (rank : 63)	θ value	1.43324e-05 (rank : 27)
Query Neighborhood Hits	161	Target Neighborhood Hits	234	Shared Neighborhood Hits	123
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NCK1_HUMAN
NC score	0.407397 (rank : 64)	θ value	0.0330416 (rank : 88)
Query Neighborhood Hits	161	Target Neighborhood Hits	312	Shared Neighborhood Hits	129
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

OSTF1_HUMAN
NC score	0.404089 (rank : 65)	θ value	0.00298849 (rank : 61)
Query Neighborhood Hits	161	Target Neighborhood Hits	466	Shared Neighborhood Hits	128
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SNX18_MOUSE
NC score	0.403537 (rank : 66)	θ value	0.00228821 (rank : 58)
Query Neighborhood Hits	161	Target Neighborhood Hits	198	Shared Neighborhood Hits	122
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ITSN2_HUMAN
NC score	0.402309 (rank : 67)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	161	Target Neighborhood Hits	1173	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CRKL_MOUSE
NC score	0.400914 (rank : 68)	θ value	0.0563607 (rank : 98)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	123
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DBNL_HUMAN
NC score	0.398469 (rank : 69)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	161	Target Neighborhood Hits	244	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

PACN3_MOUSE
NC score	0.397028 (rank : 70)	θ value	0.0563607 (rank : 101)
Query Neighborhood Hits	161	Target Neighborhood Hits	380	Shared Neighborhood Hits	124
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SNX18_HUMAN
NC score	0.396978 (rank : 71)	θ value	0.00509761 (rank : 67)
Query Neighborhood Hits	161	Target Neighborhood Hits	207	Shared Neighborhood Hits	121
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PACN3_HUMAN
NC score	0.395702 (rank : 72)	θ value	0.0563607 (rank : 100)
Query Neighborhood Hits	161	Target Neighborhood Hits	385	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

OSTF1_MOUSE
NC score	0.394944 (rank : 73)	θ value	0.00298849 (rank : 62)
Query Neighborhood Hits	161	Target Neighborhood Hits	467	Shared Neighborhood Hits	129
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_MOUSE
NC score	0.392590 (rank : 74)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	161	Target Neighborhood Hits	306	Shared Neighborhood Hits	116
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

NEBL_HUMAN
NC score	0.385558 (rank : 75)	θ value	0.0193708 (rank : 80)
Query Neighborhood Hits	161	Target Neighborhood Hits	457	Shared Neighborhood Hits	123
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NCK2_HUMAN
NC score	0.382810 (rank : 76)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	161	Target Neighborhood Hits	310	Shared Neighborhood Hits	127
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ITSN2_MOUSE
NC score	0.380975 (rank : 77)	θ value	2.88788e-06 (rank : 22)
Query Neighborhood Hits	161	Target Neighborhood Hits	1371	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
NC score	0.375117 (rank : 78)	θ value	0.0148317 (rank : 79)
Query Neighborhood Hits	161	Target Neighborhood Hits	430	Shared Neighborhood Hits	130
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.373445 (rank : 79)	θ value	0.00869519 (rank : 75)
Query Neighborhood Hits	161	Target Neighborhood Hits	452	Shared Neighborhood Hits	130
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

EFS_MOUSE
NC score	0.372518 (rank : 80)	θ value	0.00509761 (rank : 65)
Query Neighborhood Hits	161	Target Neighborhood Hits	389	Shared Neighborhood Hits	114
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ITSN1_HUMAN
NC score	0.372478 (rank : 81)	θ value	2.61198e-07 (rank : 13)
Query Neighborhood Hits	161	Target Neighborhood Hits	1757	Shared Neighborhood Hits	136
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.370485 (rank : 82)	θ value	4.92598e-06 (rank : 23)
Query Neighborhood Hits	161	Target Neighborhood Hits	1669	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

EFS_HUMAN
NC score	0.365587 (rank : 83)	θ value	0.00869519 (rank : 73)
Query Neighborhood Hits	161	Target Neighborhood Hits	348	Shared Neighborhood Hits	114
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

AHI1_HUMAN
NC score	0.357408 (rank : 84)	θ value	0.000461057 (rank : 43)
Query Neighborhood Hits	161	Target Neighborhood Hits	537	Shared Neighborhood Hits	130
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
NC score	0.357365 (rank : 85)	θ value	0.00298849 (rank : 59)
Query Neighborhood Hits	161	Target Neighborhood Hits	496	Shared Neighborhood Hits	131
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NPHP1_MOUSE
NC score	0.354895 (rank : 86)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	161	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ARHG4_MOUSE
NC score	0.354418 (rank : 87)	θ value	0.000786445 (rank : 47)
Query Neighborhood Hits	161	Target Neighborhood Hits	185	Shared Neighborhood Hits	94
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

NEBU_HUMAN
NC score	0.351465 (rank : 88)	θ value	0.00869519 (rank : 74)
Query Neighborhood Hits	161	Target Neighborhood Hits	420	Shared Neighborhood Hits	125
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

VAV2_MOUSE
NC score	0.351246 (rank : 89)	θ value	0.0431538 (rank : 95)
Query Neighborhood Hits	161	Target Neighborhood Hits	456	Shared Neighborhood Hits	127
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.350214 (rank : 90)	θ value	0.0431538 (rank : 94)
Query Neighborhood Hits	161	Target Neighborhood Hits	453	Shared Neighborhood Hits	127
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

PEX13_MOUSE
NC score	0.346838 (rank : 91)	θ value	0.125558 (rank : 112)
Query Neighborhood Hits	161	Target Neighborhood Hits	126	Shared Neighborhood Hits	92
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_HUMAN
NC score	0.344487 (rank : 92)	θ value	0.0736092 (rank : 105)
Query Neighborhood Hits	161	Target Neighborhood Hits	128	Shared Neighborhood Hits	90
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

CT032_HUMAN
NC score	0.340395 (rank : 93)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	161	Target Neighborhood Hits	235	Shared Neighborhood Hits	107
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

RHG04_HUMAN
NC score	0.339620 (rank : 94)	θ value	0.00102713 (rank : 52)
Query Neighborhood Hits	161	Target Neighborhood Hits	307	Shared Neighborhood Hits	117
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SRGP2_MOUSE
NC score	0.327629 (rank : 95)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	161	Target Neighborhood Hits	324	Shared Neighborhood Hits	113
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

BCAR1_MOUSE
NC score	0.327024 (rank : 96)	θ value	0.62314 (rank : 121)
Query Neighborhood Hits	161	Target Neighborhood Hits	438	Shared Neighborhood Hits	122
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

VAV3_HUMAN
NC score	0.323546 (rank : 97)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	161	Target Neighborhood Hits	398	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SRGP2_HUMAN
NC score	0.322473 (rank : 98)	θ value	0.000121331 (rank : 35)
Query Neighborhood Hits	161	Target Neighborhood Hits	331	Shared Neighborhood Hits	112
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

BCAR1_HUMAN
NC score	0.317700 (rank : 99)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	161	Target Neighborhood Hits	554	Shared Neighborhood Hits	124
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SRGP1_HUMAN
NC score	0.314072 (rank : 100)	θ value	0.000121331 (rank : 34)
Query Neighborhood Hits	161	Target Neighborhood Hits	390	Shared Neighborhood Hits	110
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

VAV3_MOUSE
NC score	0.312411 (rank : 101)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	161	Target Neighborhood Hits	404	Shared Neighborhood Hits	123
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

RUSC1_HUMAN
NC score	0.309821 (rank : 102)	θ value	0.365318 (rank : 117)
Query Neighborhood Hits	161	Target Neighborhood Hits	226	Shared Neighborhood Hits	103
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
NC score	0.306330 (rank : 103)	θ value	0.0736092 (rank : 106)
Query Neighborhood Hits	161	Target Neighborhood Hits	206	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

CASL_MOUSE
NC score	0.305881 (rank : 104)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	114
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

FNBP2_HUMAN
NC score	0.303422 (rank : 105)	θ value	0.000786445 (rank : 48)
Query Neighborhood Hits	161	Target Neighborhood Hits	432	Shared Neighborhood Hits	111
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CASL_HUMAN
NC score	0.301488 (rank : 106)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	161	Target Neighborhood Hits	259	Shared Neighborhood Hits	114
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

NPHP1_HUMAN
NC score	0.296193 (rank : 107)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	109
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

DDEF1_MOUSE
NC score	0.272148 (rank : 108)	θ value	0.00509761 (rank : 64)
Query Neighborhood Hits	161	Target Neighborhood Hits	592	Shared Neighborhood Hits	112
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NOXO1_MOUSE
NC score	0.265713 (rank : 109)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	161	Target Neighborhood Hits	114	Shared Neighborhood Hits	87
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

ANM2_HUMAN
NC score	0.258606 (rank : 110)	θ value	0.813845 (rank : 123)
Query Neighborhood Hits	161	Target Neighborhood Hits	175	Shared Neighborhood Hits	110
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SHLB1_MOUSE
NC score	0.257765 (rank : 111)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SHLB1_HUMAN
NC score	0.255433 (rank : 112)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	161	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

ANM2_MOUSE
NC score	0.254930 (rank : 113)	θ value	0.0563607 (rank : 97)
Query Neighborhood Hits	161	Target Neighborhood Hits	175	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

RHG26_HUMAN
NC score	0.254774 (rank : 114)	θ value	0.0961366 (rank : 111)
Query Neighborhood Hits	161	Target Neighborhood Hits	281	Shared Neighborhood Hits	108
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

DDEF2_MOUSE
NC score	0.251404 (rank : 115)	θ value	0.0148317 (rank : 78)
Query Neighborhood Hits	161	Target Neighborhood Hits	625	Shared Neighborhood Hits	111
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.250217 (rank : 116)	θ value	0.00665767 (rank : 70)
Query Neighborhood Hits	161	Target Neighborhood Hits	599	Shared Neighborhood Hits	114
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PLCG1_MOUSE
NC score	0.243741 (rank : 117)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	161	Target Neighborhood Hits	314	Shared Neighborhood Hits	115
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RIMB2_HUMAN
NC score	0.243385 (rank : 118)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	161	Target Neighborhood Hits	263	Shared Neighborhood Hits	93
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA2_HUMAN
NC score	0.241480 (rank : 119)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	161	Target Neighborhood Hits	888	Shared Neighborhood Hits	130
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTA1_MOUSE
NC score	0.240386 (rank : 120)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	161	Target Neighborhood Hits	675	Shared Neighborhood Hits	121
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_HUMAN
NC score	0.240069 (rank : 121)	θ value	5.44631e-05 (rank : 32)
Query Neighborhood Hits	161	Target Neighborhood Hits	748	Shared Neighborhood Hits	126
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SNX9_HUMAN
NC score	0.235638 (rank : 122)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	161	Target Neighborhood Hits	148	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

RIMB2_MOUSE
NC score	0.235146 (rank : 123)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	161	Target Neighborhood Hits	246	Shared Neighborhood Hits	83
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PLCG2_HUMAN
NC score	0.233496 (rank : 124)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	161	Target Neighborhood Hits	280	Shared Neighborhood Hits	111
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

MYO1F_MOUSE
NC score	0.228944 (rank : 125)	θ value	0.00175202 (rank : 56)
Query Neighborhood Hits	161	Target Neighborhood Hits	262	Shared Neighborhood Hits	125
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PLCG1_HUMAN
NC score	0.228814 (rank : 126)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	111
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MYO1F_HUMAN
NC score	0.228723 (rank : 127)	θ value	0.00228821 (rank : 57)
Query Neighborhood Hits	161	Target Neighborhood Hits	275	Shared Neighborhood Hits	125
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SHLB2_MOUSE
NC score	0.223529 (rank : 128)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	161	Target Neighborhood Hits	88	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.221856 (rank : 129)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	161	Target Neighborhood Hits	86	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

MYO1E_HUMAN
NC score	0.218427 (rank : 130)	θ value	0.00509761 (rank : 66)
Query Neighborhood Hits	161	Target Neighborhood Hits	293	Shared Neighborhood Hits	125
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SNX9_MOUSE
NC score	0.212695 (rank : 131)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	161	Target Neighborhood Hits	141	Shared Neighborhood Hits	89
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

NOXO1_HUMAN
NC score	0.210965 (rank : 132)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	161	Target Neighborhood Hits	100	Shared Neighborhood Hits	70
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BI2L1_HUMAN
NC score	0.210443 (rank : 133)	θ value	0.0431538 (rank : 91)
Query Neighborhood Hits	161	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ARHG5_HUMAN
NC score	0.208219 (rank : 134)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	161	Target Neighborhood Hits	172	Shared Neighborhood Hits	72
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ES8L3_MOUSE
NC score	0.207247 (rank : 135)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	161	Target Neighborhood Hits	168	Shared Neighborhood Hits	101
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

IASPP_HUMAN
NC score	0.200309 (rank : 136)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	161	Target Neighborhood Hits	688	Shared Neighborhood Hits	116
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BI2L1_MOUSE
NC score	0.189123 (rank : 137)	θ value	0.0330416 (rank : 85)
Query Neighborhood Hits	161	Target Neighborhood Hits	197	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ASPP1_MOUSE
NC score	0.183426 (rank : 138)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	161	Target Neighborhood Hits	1244	Shared Neighborhood Hits	119
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.182909 (rank : 139)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	161	Target Neighborhood Hits	956	Shared Neighborhood Hits	120
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_MOUSE
NC score	0.182211 (rank : 140)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	161	Target Neighborhood Hits	1024	Shared Neighborhood Hits	117
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TCGAP_MOUSE
NC score	0.180825 (rank : 141)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	161	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

BAIP2_MOUSE
NC score	0.177000 (rank : 142)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	161	Target Neighborhood Hits	185	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.174429 (rank : 143)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	161	Target Neighborhood Hits	192	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

NGEF_HUMAN
NC score	0.172011 (rank : 144)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
NC score	0.169672 (rank : 145)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ES8L3_HUMAN
NC score	0.167936 (rank : 146)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	161	Target Neighborhood Hits	206	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

TCGAP_HUMAN
NC score	0.164057 (rank : 147)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	161	Target Neighborhood Hits	872	Shared Neighborhood Hits	101
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SNX22_HUMAN
NC score	0.160543 (rank : 148)	θ value	0.0330416 (rank : 89)
Query Neighborhood Hits	161	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	Q96L94, Q9H844	Gene names	SNX22
Domain Architecture
Description	Sorting nexin-22.

PREX1_HUMAN
NC score	0.158351 (rank : 149)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	161	Target Neighborhood Hits	177	Shared Neighborhood Hits	20
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
NC score	0.157548 (rank : 150)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	161	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

STS2_HUMAN
NC score	0.153817 (rank : 151)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	161	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

ARHGG_MOUSE
NC score	0.153731 (rank : 152)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	161	Target Neighborhood Hits	152	Shared Neighborhood Hits	50
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SNX24_MOUSE
NC score	0.153313 (rank : 153)	θ value	0.0252991 (rank : 83)
Query Neighborhood Hits	161	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CRB0	Gene names	Snx24
Domain Architecture	No domain graphic available
Description	Sorting nexin-24.

MCF2L_MOUSE
NC score	0.151695 (rank : 154)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	161	Target Neighborhood Hits	255	Shared Neighborhood Hits	37
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ASPP2_HUMAN
NC score	0.150570 (rank : 155)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	161	Target Neighborhood Hits	1156	Shared Neighborhood Hits	105
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

TIAM1_MOUSE
NC score	0.147459 (rank : 156)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	161	Target Neighborhood Hits	205	Shared Neighborhood Hits	20
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

SHAN2_MOUSE
NC score	0.147084 (rank : 157)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	161	Target Neighborhood Hits	446	Shared Neighborhood Hits	83
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ARHG3_HUMAN
NC score	0.146449 (rank : 158)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	161	Target Neighborhood Hits	82	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.146386 (rank : 159)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	161	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

RUSC2_HUMAN
NC score	0.146038 (rank : 160)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	161	Target Neighborhood Hits	205	Shared Neighborhood Hits	55
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SNX24_HUMAN
NC score	0.145973 (rank : 161)	θ value	0.0563607 (rank : 102)
Query Neighborhood Hits	161	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y343, Q6UY33	Gene names	SNX24
Domain Architecture
Description	Sorting nexin-24.

TIAM1_HUMAN
NC score	0.144584 (rank : 162)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG8_MOUSE
NC score	0.142648 (rank : 163)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	161	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

EPS8_MOUSE
NC score	0.142455 (rank : 164)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	90
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

SPN90_HUMAN
NC score	0.141826 (rank : 165)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

EPS8_HUMAN
NC score	0.139023 (rank : 166)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ARHGG_HUMAN
NC score	0.138703 (rank : 167)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	161	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ES8L2_HUMAN
NC score	0.136070 (rank : 168)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	161	Target Neighborhood Hits	193	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ARHG8_HUMAN
NC score	0.134604 (rank : 169)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	161	Target Neighborhood Hits	85	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

STS1_HUMAN
NC score	0.134584 (rank : 170)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	161	Target Neighborhood Hits	106	Shared Neighborhood Hits	62
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
NC score	0.132920 (rank : 171)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	161	Target Neighborhood Hits	104	Shared Neighborhood Hits	60
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SNX20_MOUSE
NC score	0.131893 (rank : 172)	θ value	0.163984 (rank : 115)
Query Neighborhood Hits	161	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2Y5, Q544B6	Gene names	Snx20
Domain Architecture	No domain graphic available
Description	Sorting nexin-20.

MCF2_HUMAN
NC score	0.131014 (rank : 173)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	22
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

RUSC2_MOUSE
NC score	0.130007 (rank : 174)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	161	Target Neighborhood Hits	305	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ES8L2_MOUSE
NC score	0.129874 (rank : 175)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	161	Target Neighborhood Hits	169	Shared Neighborhood Hits	82
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L1_MOUSE
NC score	0.126731 (rank : 176)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	161	Target Neighborhood Hits	143	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ARHGA_MOUSE
NC score	0.126282 (rank : 177)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	161	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

RIMB1_HUMAN
NC score	0.125963 (rank : 178)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	161	Target Neighborhood Hits	1479	Shared Neighborhood Hits	104
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

AMPH_HUMAN
NC score	0.123922 (rank : 179)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	161	Target Neighborhood Hits	455	Shared Neighborhood Hits	62
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RIMB1_MOUSE
NC score	0.123437 (rank : 180)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	161	Target Neighborhood Hits	1376	Shared Neighborhood Hits	110
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

DOCK1_HUMAN
NC score	0.122274 (rank : 181)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	161	Target Neighborhood Hits	191	Shared Neighborhood Hits	89
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SLY_MOUSE
NC score	0.121896 (rank : 182)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	161	Target Neighborhood Hits	108	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SNX16_MOUSE
NC score	0.120458 (rank : 183)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	161	Target Neighborhood Hits	82	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C080	Gene names	Snx16
Domain Architecture	No domain graphic available
Description	Sorting nexin-16.

SPN90_MOUSE
NC score	0.119720 (rank : 184)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

ARHGA_HUMAN
NC score	0.119603 (rank : 185)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	161	Target Neighborhood Hits	187	Shared Neighborhood Hits	19
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ES8L1_HUMAN
NC score	0.119107 (rank : 186)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	161	Target Neighborhood Hits	162	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CIP4_HUMAN
NC score	0.118485 (rank : 187)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	161	Target Neighborhood Hits	374	Shared Neighborhood Hits	51
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

P85A_MOUSE
NC score	0.116383 (rank : 188)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	161	Target Neighborhood Hits	435	Shared Neighborhood Hits	79
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SNX16_HUMAN
NC score	0.116157 (rank : 189)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	161	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P57768, Q8N4U3	Gene names	SNX16
Domain Architecture
Description	Sorting nexin-16.

M3KL4_HUMAN
NC score	0.114409 (rank : 190)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	161	Target Neighborhood Hits	1087	Shared Neighborhood Hits	121
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

BIN1_HUMAN
NC score	0.113582 (rank : 191)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	161	Target Neighborhood Hits	335	Shared Neighborhood Hits	54
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SHAN1_HUMAN
NC score	0.111440 (rank : 192)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	161	Target Neighborhood Hits	1041	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

HAPIP_HUMAN
NC score	0.110627 (rank : 193)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	161	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ECT2_MOUSE
NC score	0.110438 (rank : 194)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	161	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

BIN1_MOUSE
NC score	0.109628 (rank : 195)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	161	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

AMPH_MOUSE
NC score	0.108630 (rank : 196)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	161	Target Neighborhood Hits	291	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ECT2_HUMAN
NC score	0.106878 (rank : 197)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	161	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

P85A_HUMAN
NC score	0.106548 (rank : 198)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	161	Target Neighborhood Hits	479	Shared Neighborhood Hits	74
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BCR_HUMAN
NC score	0.106339 (rank : 199)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	161	Target Neighborhood Hits	204	Shared Neighborhood Hits	23
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

M3K11_HUMAN
NC score	0.105994 (rank : 200)	θ value	0.0961366 (rank : 109)
Query Neighborhood Hits	161	Target Neighborhood Hits	1136	Shared Neighborhood Hits	120
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

SLY_HUMAN
NC score	0.104514 (rank : 201)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	161	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SNX14_HUMAN
NC score	0.101985 (rank : 202)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	161	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5W7, Q9BSD1	Gene names	SNX14
Domain Architecture
Description	Sorting nexin-14.

FYN_MOUSE
NC score	0.101551 (rank : 203)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	161	Target Neighborhood Hits	1073	Shared Neighborhood Hits	127
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SNX8_HUMAN
NC score	0.101448 (rank : 204)	θ value	0.813845 (rank : 125)
Query Neighborhood Hits	161	Target Neighborhood Hits	66	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5X2, Q96I67	Gene names	SNX8
Domain Architecture
Description	Sorting nexin-8.

ARHG1_HUMAN
NC score	0.100712 (rank : 205)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	161	Target Neighborhood Hits	176	Shared Neighborhood Hits	16
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

M3K9_HUMAN
NC score	0.100018 (rank : 206)	θ value	1.38821 (rank : 127)
Query Neighborhood Hits	161	Target Neighborhood Hits	1123	Shared Neighborhood Hits	123
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

FYN_HUMAN
NC score	0.099769 (rank : 207)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	161	Target Neighborhood Hits	1078	Shared Neighborhood Hits	127
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.098488 (rank : 208)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	161	Target Neighborhood Hits	1058	Shared Neighborhood Hits	127
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_HUMAN
NC score	0.098231 (rank : 209)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	161	Target Neighborhood Hits	1067	Shared Neighborhood Hits	123
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SNX14_MOUSE
NC score	0.098075 (rank : 210)	θ value	1.06291 (rank : 126)
Query Neighborhood Hits	161	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

ARHGB_HUMAN
NC score	0.097011 (rank : 211)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	161	Target Neighborhood Hits	375	Shared Neighborhood Hits	17
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

YES_MOUSE
NC score	0.096920 (rank : 212)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	161	Target Neighborhood Hits	1052	Shared Neighborhood Hits	123
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SNX2_HUMAN
NC score	0.096438 (rank : 213)	θ value	0.0736092 (rank : 107)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	O60749, O43650, P82862, Q53XK8, Q597H6, Q9BTS8	Gene names	SNX2, TRG9
Domain Architecture
Description	Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9).

SNX7_HUMAN
NC score	0.096424 (rank : 214)	θ value	0.62314 (rank : 122)
Query Neighborhood Hits	161	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UNH6, Q86U82, Q8WVD4, Q96FW9, Q9Y3Z7	Gene names	SNX7
Domain Architecture
Description	Sorting nexin-7.

SNX19_HUMAN
NC score	0.096198 (rank : 215)	θ value	0.163984 (rank : 114)
Query Neighborhood Hits	161	Target Neighborhood Hits	123	Shared Neighborhood Hits	18
SwissProt Accessions	Q92543	Gene names	SNX19, KIAA0254
Domain Architecture
Description	Sorting nexin-19.

SNX2_MOUSE
NC score	0.095917 (rank : 216)	θ value	0.0736092 (rank : 108)
Query Neighborhood Hits	161	Target Neighborhood Hits	156	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CWK8, Q3UKW3, Q9CQV0	Gene names	Snx2
Domain Architecture
Description	Sorting nexin-2.

ARHGC_HUMAN
NC score	0.095316 (rank : 217)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	161	Target Neighborhood Hits	351	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

YES_HUMAN
NC score	0.095141 (rank : 218)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	161	Target Neighborhood Hits	1059	Shared Neighborhood Hits	123
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHGC_MOUSE
NC score	0.094773 (rank : 219)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	161	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FGD3_MOUSE
NC score	0.093417 (rank : 220)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	161	Target Neighborhood Hits	257	Shared Neighborhood Hits	18
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ABR_HUMAN
NC score	0.093072 (rank : 221)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	161	Target Neighborhood Hits	166	Shared Neighborhood Hits	23
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

EM55_HUMAN
NC score	0.092839 (rank : 222)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	161	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

LBC_HUMAN
NC score	0.092698 (rank : 223)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

FGD4_HUMAN
NC score	0.091174 (rank : 224)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	161	Target Neighborhood Hits	219	Shared Neighborhood Hits	21
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.091008 (rank : 225)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

GNRP_MOUSE
NC score	0.090502 (rank : 226)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	161	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGF_HUMAN
NC score	0.090493 (rank : 227)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	161	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

FGR_MOUSE
NC score	0.089871 (rank : 228)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	161	Target Neighborhood Hits	1069	Shared Neighborhood Hits	125
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ARHG2_MOUSE
NC score	0.089398 (rank : 229)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	161	Target Neighborhood Hits	120	Shared Neighborhood Hits	19
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD2_HUMAN
NC score	0.089154 (rank : 230)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

EM55_MOUSE
NC score	0.088729 (rank : 231)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	161	Target Neighborhood Hits	221	Shared Neighborhood Hits	71
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

RGNEF_MOUSE
NC score	0.087680 (rank : 232)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	161	Target Neighborhood Hits	641	Shared Neighborhood Hits	26
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FGD3_HUMAN
NC score	0.087659 (rank : 233)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	161	Target Neighborhood Hits	249	Shared Neighborhood Hits	17
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHG2_HUMAN
NC score	0.086885 (rank : 234)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	161	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

SNX7_MOUSE
NC score	0.086358 (rank : 235)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	161	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CY18	Gene names	Snx7
Domain Architecture
Description	Sorting nexin-7.

FGD2_MOUSE
NC score	0.084309 (rank : 236)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	161	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

BTK_HUMAN
NC score	0.083543 (rank : 237)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	161	Target Neighborhood Hits	1026	Shared Neighborhood Hits	124
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

M3K10_HUMAN
NC score	0.082986 (rank : 238)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	161	Target Neighborhood Hits	1071	Shared Neighborhood Hits	111
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

PKHG4_HUMAN
NC score	0.081326 (rank : 239)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	161	Target Neighborhood Hits	200	Shared Neighborhood Hits	16
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

P85B_HUMAN
NC score	0.080331 (rank : 240)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	161	Target Neighborhood Hits	543	Shared Neighborhood Hits	51
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FARP2_MOUSE
NC score	0.080076 (rank : 241)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	161	Target Neighborhood Hits	209	Shared Neighborhood Hits	20
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SNX8_MOUSE
NC score	0.079724 (rank : 242)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	161	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFD4, Q8BLI6, Q8BUQ7	Gene names	Snx8
Domain Architecture	No domain graphic available
Description	Sorting nexin-8.

SLAP2_HUMAN
NC score	0.079447 (rank : 243)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	161	Target Neighborhood Hits	139	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

JIP2_MOUSE
NC score	0.078949 (rank : 244)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	161	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

BTK_MOUSE
NC score	0.077519 (rank : 245)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	161	Target Neighborhood Hits	1017	Shared Neighborhood Hits	118
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FGD1_HUMAN
NC score	0.076769 (rank : 246)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	161	Target Neighborhood Hits	367	Shared Neighborhood Hits	21
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

JIP2_HUMAN
NC score	0.076147 (rank : 247)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	161	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

FGD1_MOUSE
NC score	0.076092 (rank : 248)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	161	Target Neighborhood Hits	387	Shared Neighborhood Hits	18
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RHG09_HUMAN
NC score	0.076006 (rank : 249)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	161	Target Neighborhood Hits	186	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

FARP1_HUMAN
NC score	0.075171 (rank : 250)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	161	Target Neighborhood Hits	241	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

HCK_MOUSE
NC score	0.074876 (rank : 251)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	161	Target Neighborhood Hits	1029	Shared Neighborhood Hits	124
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.074793 (rank : 252)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	161	Target Neighborhood Hits	1035	Shared Neighborhood Hits	124
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SLAP2_MOUSE
NC score	0.074298 (rank : 253)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	161	Target Neighborhood Hits	136	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

FRK_HUMAN
NC score	0.074296 (rank : 254)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	161	Target Neighborhood Hits	1058	Shared Neighborhood Hits	124
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

P85B_MOUSE
NC score	0.074098 (rank : 255)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	161	Target Neighborhood Hits	519	Shared Neighborhood Hits	51
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CHIN_MOUSE
NC score	0.074049 (rank : 256)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	161	Target Neighborhood Hits	229	Shared Neighborhood Hits	35
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ARHG1_MOUSE
NC score	0.073914 (rank : 257)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	161	Target Neighborhood Hits	266	Shared Neighborhood Hits	11
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FARP2_HUMAN
NC score	0.073900 (rank : 258)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	161	Target Neighborhood Hits	240	Shared Neighborhood Hits	17
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CHIO_HUMAN
NC score	0.073691 (rank : 259)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	161	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GNRP_HUMAN
NC score	0.073274 (rank : 260)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	161	Target Neighborhood Hits	239	Shared Neighborhood Hits	17
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SRC_MOUSE
NC score	0.073197 (rank : 261)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	161	Target Neighborhood Hits	1033	Shared Neighborhood Hits	114
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

CHIN_HUMAN
NC score	0.072807 (rank : 262)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SNX13_HUMAN
NC score	0.071812 (rank : 263)	θ value	0.813845 (rank : 124)
Query Neighborhood Hits	161	Target Neighborhood Hits	84	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5W8, O94821, Q8WVZ2, Q8WXH8	Gene names	SNX13, KIAA0713
Domain Architecture
Description	Sorting nexin-13 (RGS domain- and PHOX domain-containing protein) (RGS-PX1).

RASA1_HUMAN
NC score	0.071478 (rank : 264)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	161	Target Neighborhood Hits	258	Shared Neighborhood Hits	39
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

JIP1_MOUSE
NC score	0.071310 (rank : 265)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	161	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_HUMAN
NC score	0.071264 (rank : 266)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	161	Target Neighborhood Hits	271	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

FGD6_MOUSE
NC score	0.070945 (rank : 267)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	161	Target Neighborhood Hits	282	Shared Neighborhood Hits	19
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SNX13_MOUSE
NC score	0.070042 (rank : 268)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	161	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PHS6	Gene names	Snx13
Domain Architecture	No domain graphic available
Description	Sorting nexin-13.

SNX11_HUMAN
NC score	0.069505 (rank : 269)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	161	Target Neighborhood Hits	47	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5W9, Q9H885	Gene names	SNX11
Domain Architecture
Description	Sorting nexin-11.

SNX1_MOUSE
NC score	0.068732 (rank : 270)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	161	Target Neighborhood Hits	157	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

SASH1_HUMAN
NC score	0.068675 (rank : 271)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	161	Target Neighborhood Hits	292	Shared Neighborhood Hits	46
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

3BP1_HUMAN
NC score	0.068421 (rank : 272)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	161	Target Neighborhood Hits	376	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

FGD6_HUMAN
NC score	0.067393 (rank : 273)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	161	Target Neighborhood Hits	237	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FUT8_HUMAN
NC score	0.066958 (rank : 274)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	161	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

LYN_HUMAN
NC score	0.066480 (rank : 275)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	161	Target Neighborhood Hits	1022	Shared Neighborhood Hits	113
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SNX1_HUMAN
NC score	0.066345 (rank : 276)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	161	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

MPP6_HUMAN
NC score	0.065748 (rank : 277)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	161	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

RHG12_MOUSE
NC score	0.065255 (rank : 278)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	161	Target Neighborhood Hits	204	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

LYN_MOUSE
NC score	0.064859 (rank : 279)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	161	Target Neighborhood Hits	1023	Shared Neighborhood Hits	111
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SASH1_MOUSE
NC score	0.063970 (rank : 280)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	161	Target Neighborhood Hits	263	Shared Neighborhood Hits	45
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

P3C2B_HUMAN
NC score	0.063844 (rank : 281)	θ value	0.0563607 (rank : 99)
Query Neighborhood Hits	161	Target Neighborhood Hits	148	Shared Neighborhood Hits	18
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

SAMN1_HUMAN
NC score	0.063713 (rank : 282)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	161	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

FUT8_MOUSE
NC score	0.063337 (rank : 283)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	161	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

SNX11_MOUSE
NC score	0.062456 (rank : 284)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	161	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WL6, Q3V3A6	Gene names	Snx11
Domain Architecture	No domain graphic available
Description	Sorting nexin-11.

MPP6_MOUSE
NC score	0.062203 (rank : 285)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	161	Target Neighborhood Hits	187	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

SAMN1_MOUSE
NC score	0.061374 (rank : 286)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	161	Target Neighborhood Hits	69	Shared Neighborhood Hits	34
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

OPHN1_HUMAN
NC score	0.061185 (rank : 287)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	161	Target Neighborhood Hits	161	Shared Neighborhood Hits	13
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG12_HUMAN
NC score	0.060552 (rank : 288)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	161	Target Neighborhood Hits	190	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TXK_MOUSE
NC score	0.059897 (rank : 289)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	161	Target Neighborhood Hits	980	Shared Neighborhood Hits	96
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CSK_MOUSE
NC score	0.059308 (rank : 290)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	161	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.059082 (rank : 291)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	161	Target Neighborhood Hits	1009	Shared Neighborhood Hits	96
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

PTK6_HUMAN
NC score	0.058474 (rank : 292)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	161	Target Neighborhood Hits	1020	Shared Neighborhood Hits	112
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BLK_HUMAN
NC score	0.058381 (rank : 293)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	161	Target Neighborhood Hits	994	Shared Neighborhood Hits	96
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SLAP1_HUMAN
NC score	0.058138 (rank : 294)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	161	Target Neighborhood Hits	113	Shared Neighborhood Hits	23
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PTK6_MOUSE
NC score	0.057974 (rank : 295)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	161	Target Neighborhood Hits	1026	Shared Neighborhood Hits	109
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

OPHN1_MOUSE
NC score	0.057806 (rank : 296)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	161	Target Neighborhood Hits	174	Shared Neighborhood Hits	12
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

SOS1_HUMAN
NC score	0.057736 (rank : 297)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	161	Target Neighborhood Hits	274	Shared Neighborhood Hits	14
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

CHIO_MOUSE
NC score	0.057477 (rank : 298)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	161	Target Neighborhood Hits	130	Shared Neighborhood Hits	15
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SOS1_MOUSE
NC score	0.056716 (rank : 299)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	161	Target Neighborhood Hits	281	Shared Neighborhood Hits	14
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

MPP5_HUMAN
NC score	0.056266 (rank : 300)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	161	Target Neighborhood Hits	231	Shared Neighborhood Hits	54
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

REPS2_MOUSE
NC score	0.056057 (rank : 301)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	161	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SLAP1_MOUSE
NC score	0.055920 (rank : 302)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	161	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

REPS2_HUMAN
NC score	0.055875 (rank : 303)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	161	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

BLK_MOUSE
NC score	0.055780 (rank : 304)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	161	Target Neighborhood Hits	992	Shared Neighborhood Hits	86
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DOCK2_HUMAN
NC score	0.055399 (rank : 305)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	35
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

MPP5_MOUSE
NC score	0.055298 (rank : 306)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	161	Target Neighborhood Hits	226	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

SNX27_HUMAN
NC score	0.054379 (rank : 307)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	161	Target Neighborhood Hits	54	Shared Neighborhood Hits	17
SwissProt Accessions	Q96L92	Gene names	SNX27
Domain Architecture
Description	Sorting nexin-27.

APS_HUMAN
NC score	0.054358 (rank : 308)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	161	Target Neighborhood Hits	162	Shared Neighborhood Hits	26
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

TEC_HUMAN
NC score	0.053948 (rank : 309)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	161	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DAPP1_MOUSE
NC score	0.053631 (rank : 310)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	161	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PPIP2_HUMAN
NC score	0.053513 (rank : 311)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	161	Target Neighborhood Hits	254	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

SHC3_MOUSE
NC score	0.053364 (rank : 312)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	161	Target Neighborhood Hits	151	Shared Neighborhood Hits	25
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

DOCK2_MOUSE
NC score	0.053289 (rank : 313)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	161	Target Neighborhood Hits	104	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

SHB_MOUSE
NC score	0.052594 (rank : 314)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	161	Target Neighborhood Hits	137	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

TEC_MOUSE
NC score	0.052568 (rank : 315)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	161	Target Neighborhood Hits	1006	Shared Neighborhood Hits	97
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH21B_HUMAN
NC score	0.052544 (rank : 316)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	19
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

TXK_HUMAN
NC score	0.052086 (rank : 317)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	161	Target Neighborhood Hits	971	Shared Neighborhood Hits	85
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

DAPP1_HUMAN
NC score	0.051971 (rank : 318)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	161	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SNX4_MOUSE
NC score	0.051915 (rank : 319)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	161	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q91YJ2	Gene names	Snx4
Domain Architecture	No domain graphic available
Description	Sorting nexin-4.

TRIO_HUMAN
NC score	0.051328 (rank : 320)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	161	Target Neighborhood Hits	1580	Shared Neighborhood Hits	52
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SH21B_MOUSE
NC score	0.051067 (rank : 321)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	161	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

LCK_HUMAN
NC score	0.050608 (rank : 322)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	161	Target Neighborhood Hits	987	Shared Neighborhood Hits	75
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SNX25_HUMAN
NC score	0.050560 (rank : 323)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	161	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3E2	Gene names	SNX25
Domain Architecture
Description	Sorting nexin-25.

SHE_MOUSE
NC score	0.050350 (rank : 324)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	161	Target Neighborhood Hits	169	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

LCK_MOUSE
NC score	0.050271 (rank : 325)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	161	Target Neighborhood Hits	981	Shared Neighborhood Hits	74
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SNX4_HUMAN
NC score	0.050237 (rank : 326)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	161	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	O95219	Gene names	SNX4
Domain Architecture
Description	Sorting nexin-4.

P3C2A_MOUSE
NC score	0.047560 (rank : 327)	θ value	0.163984 (rank : 113)
Query Neighborhood Hits	161	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.043109 (rank : 328)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	161	Target Neighborhood Hits	188	Shared Neighborhood Hits	15
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

SRMS_MOUSE
NC score	0.036483 (rank : 329)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	161	Target Neighborhood Hits	964	Shared Neighborhood Hits	70
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SGK3_HUMAN
NC score	0.024415 (rank : 330)	θ value	0.00665767 (rank : 72)
Query Neighborhood Hits	161	Target Neighborhood Hits	877	Shared Neighborhood Hits	38
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

RS10_MOUSE
NC score	0.023951 (rank : 331)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	161	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P63325, P09900, Q9DCR5	Gene names	Rps10
Domain Architecture	No domain graphic available
Description	40S ribosomal protein S10.

SGK3_MOUSE
NC score	0.023725 (rank : 332)	θ value	0.0193708 (rank : 81)
Query Neighborhood Hits	161	Target Neighborhood Hits	882	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

HERPU_MOUSE
NC score	0.014613 (rank : 333)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	161	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JJK5	Gene names	Herpud1
Domain Architecture
Description	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein.