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Network neighborhood for query Sequence : TIAM1_MOUSE

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TIAM1_MOUSE
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TIAM1_HUMAN
θ value	0 (rank : 1)	NC score	0.989147 (rank : 2)
Query Neighborhood Hits	205	Target Neighborhood Hits	225	Shared Neighborhood Hits	157
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	205	Target Neighborhood Hits	205	Shared Neighborhood Hits	205
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG9_HUMAN
θ value	2.51237e-26 (rank : 3)	NC score	0.733611 (rank : 7)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	2.51237e-26 (rank : 4)	NC score	0.733744 (rank : 6)
Query Neighborhood Hits	205	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PREX1_HUMAN
θ value	3.62785e-25 (rank : 5)	NC score	0.744504 (rank : 4)
Query Neighborhood Hits	205	Target Neighborhood Hits	177	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PKHG1_HUMAN
θ value	4.01107e-24 (rank : 6)	NC score	0.760973 (rank : 3)
Query Neighborhood Hits	205	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
θ value	3.88503e-19 (rank : 7)	NC score	0.740361 (rank : 5)
Query Neighborhood Hits	205	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN2_HUMAN
θ value	1.47631e-18 (rank : 8)	NC score	0.467838 (rank : 57)
Query Neighborhood Hits	205	Target Neighborhood Hits	1173	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG4_HUMAN
θ value	2.5182e-18 (rank : 9)	NC score	0.713022 (rank : 8)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ITSN2_MOUSE
θ value	7.32683e-18 (rank : 10)	NC score	0.441303 (rank : 60)
Query Neighborhood Hits	205	Target Neighborhood Hits	1371	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
θ value	1.80466e-16 (rank : 11)	NC score	0.427545 (rank : 62)
Query Neighborhood Hits	205	Target Neighborhood Hits	1757	Shared Neighborhood Hits	96
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	2.35696e-16 (rank : 12)	NC score	0.427820 (rank : 61)
Query Neighborhood Hits	205	Target Neighborhood Hits	1669	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TRIO_HUMAN
θ value	2.35696e-16 (rank : 13)	NC score	0.229642 (rank : 72)
Query Neighborhood Hits	205	Target Neighborhood Hits	1580	Shared Neighborhood Hits	91
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

HAPIP_HUMAN
θ value	1.16975e-15 (rank : 14)	NC score	0.569532 (rank : 29)
Query Neighborhood Hits	205	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV_HUMAN
θ value	2.60593e-15 (rank : 15)	NC score	0.527058 (rank : 49)
Query Neighborhood Hits	205	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	2.60593e-15 (rank : 16)	NC score	0.538864 (rank : 41)
Query Neighborhood Hits	205	Target Neighborhood Hits	430	Shared Neighborhood Hits	76
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DNMBP_MOUSE
θ value	3.40345e-15 (rank : 17)	NC score	0.574924 (rank : 23)
Query Neighborhood Hits	205	Target Neighborhood Hits	435	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG7_MOUSE
θ value	4.44505e-15 (rank : 18)	NC score	0.571531 (rank : 27)
Query Neighborhood Hits	205	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
θ value	9.90251e-15 (rank : 19)	NC score	0.572125 (rank : 25)
Query Neighborhood Hits	205	Target Neighborhood Hits	347	Shared Neighborhood Hits	76
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV3_HUMAN
θ value	1.68911e-14 (rank : 20)	NC score	0.521921 (rank : 52)
Query Neighborhood Hits	205	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHGG_MOUSE
θ value	6.41864e-14 (rank : 21)	NC score	0.628362 (rank : 17)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	68
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_HUMAN
θ value	8.38298e-14 (rank : 22)	NC score	0.558554 (rank : 36)
Query Neighborhood Hits	205	Target Neighborhood Hits	413	Shared Neighborhood Hits	78
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VAV3_MOUSE
θ value	8.38298e-14 (rank : 23)	NC score	0.522572 (rank : 51)
Query Neighborhood Hits	205	Target Neighborhood Hits	404	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ARHG6_MOUSE
θ value	1.42992e-13 (rank : 24)	NC score	0.539981 (rank : 40)
Query Neighborhood Hits	205	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

MCF2L_MOUSE
θ value	2.43908e-13 (rank : 25)	NC score	0.650670 (rank : 15)
Query Neighborhood Hits	205	Target Neighborhood Hits	255	Shared Neighborhood Hits	75
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG6_HUMAN
θ value	3.18553e-13 (rank : 26)	NC score	0.551723 (rank : 37)
Query Neighborhood Hits	205	Target Neighborhood Hits	376	Shared Neighborhood Hits	68
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

MCF2_HUMAN
θ value	1.2105e-12 (rank : 27)	NC score	0.670910 (rank : 11)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ECT2_MOUSE
θ value	2.69671e-12 (rank : 28)	NC score	0.667666 (rank : 12)
Query Neighborhood Hits	205	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_HUMAN
θ value	3.52202e-12 (rank : 29)	NC score	0.530335 (rank : 47)
Query Neighborhood Hits	205	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG3_HUMAN
θ value	4.59992e-12 (rank : 30)	NC score	0.682697 (rank : 9)
Query Neighborhood Hits	205	Target Neighborhood Hits	82	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	7.84624e-12 (rank : 31)	NC score	0.681076 (rank : 10)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

DUET_HUMAN
θ value	7.84624e-12 (rank : 32)	NC score	0.222637 (rank : 75)
Query Neighborhood Hits	205	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ECT2_HUMAN
θ value	7.84624e-12 (rank : 33)	NC score	0.652932 (rank : 14)
Query Neighborhood Hits	205	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

VAV2_MOUSE
θ value	7.84624e-12 (rank : 34)	NC score	0.527117 (rank : 48)
Query Neighborhood Hits	205	Target Neighborhood Hits	456	Shared Neighborhood Hits	71
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG8_HUMAN
θ value	3.89403e-11 (rank : 35)	NC score	0.667471 (rank : 13)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHGG_HUMAN
θ value	6.64225e-11 (rank : 36)	NC score	0.622988 (rank : 18)
Query Neighborhood Hits	205	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FARP2_HUMAN
θ value	1.47974e-10 (rank : 37)	NC score	0.403588 (rank : 65)
Query Neighborhood Hits	205	Target Neighborhood Hits	240	Shared Neighborhood Hits	77
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGB_HUMAN
θ value	9.59137e-10 (rank : 38)	NC score	0.580528 (rank : 20)
Query Neighborhood Hits	205	Target Neighborhood Hits	375	Shared Neighborhood Hits	106
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

FGD2_MOUSE
θ value	9.59137e-10 (rank : 39)	NC score	0.568474 (rank : 33)
Query Neighborhood Hits	205	Target Neighborhood Hits	163	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
θ value	2.13673e-09 (rank : 40)	NC score	0.571733 (rank : 26)
Query Neighborhood Hits	205	Target Neighborhood Hits	151	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHG8_MOUSE
θ value	2.79066e-09 (rank : 41)	NC score	0.650528 (rank : 16)
Query Neighborhood Hits	205	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHG1_MOUSE
θ value	3.64472e-09 (rank : 42)	NC score	0.533093 (rank : 45)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG1_HUMAN
θ value	4.76016e-09 (rank : 43)	NC score	0.575494 (rank : 22)
Query Neighborhood Hits	205	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

PKHG4_HUMAN
θ value	4.76016e-09 (rank : 44)	NC score	0.541242 (rank : 38)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	57
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FGD4_MOUSE
θ value	6.21693e-09 (rank : 45)	NC score	0.570469 (rank : 28)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FARP2_MOUSE
θ value	3.08544e-08 (rank : 46)	NC score	0.424331 (rank : 64)
Query Neighborhood Hits	205	Target Neighborhood Hits	209	Shared Neighborhood Hits	79
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD1_MOUSE
θ value	3.08544e-08 (rank : 47)	NC score	0.536563 (rank : 43)
Query Neighborhood Hits	205	Target Neighborhood Hits	387	Shared Neighborhood Hits	77
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_HUMAN
θ value	4.0297e-08 (rank : 48)	NC score	0.569418 (rank : 30)
Query Neighborhood Hits	205	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

GNRP_MOUSE
θ value	4.0297e-08 (rank : 49)	NC score	0.465845 (rank : 59)
Query Neighborhood Hits	205	Target Neighborhood Hits	191	Shared Neighborhood Hits	73
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD1_HUMAN
θ value	5.26297e-08 (rank : 50)	NC score	0.535634 (rank : 44)
Query Neighborhood Hits	205	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_MOUSE
θ value	5.26297e-08 (rank : 51)	NC score	0.595371 (rank : 19)
Query Neighborhood Hits	205	Target Neighborhood Hits	257	Shared Neighborhood Hits	73
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHGA_HUMAN
θ value	8.97725e-08 (rank : 52)	NC score	0.569298 (rank : 31)
Query Neighborhood Hits	205	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD3_HUMAN
θ value	8.97725e-08 (rank : 53)	NC score	0.567255 (rank : 34)
Query Neighborhood Hits	205	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

GNRP_HUMAN
θ value	1.53129e-07 (rank : 54)	NC score	0.424403 (rank : 63)
Query Neighborhood Hits	205	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
θ value	1.99992e-07 (rank : 55)	NC score	0.365810 (rank : 66)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RGNEF_MOUSE
θ value	1.99992e-07 (rank : 56)	NC score	0.477920 (rank : 55)
Query Neighborhood Hits	205	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARHGC_HUMAN
θ value	4.45536e-07 (rank : 57)	NC score	0.540782 (rank : 39)
Query Neighborhood Hits	205	Target Neighborhood Hits	351	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG2_MOUSE
θ value	7.59969e-07 (rank : 58)	NC score	0.537625 (rank : 42)
Query Neighborhood Hits	205	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGA_MOUSE
θ value	7.59969e-07 (rank : 59)	NC score	0.565219 (rank : 35)
Query Neighborhood Hits	205	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_HUMAN
θ value	7.59969e-07 (rank : 60)	NC score	0.576341 (rank : 21)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	7.59969e-07 (rank : 61)	NC score	0.568599 (rank : 32)
Query Neighborhood Hits	205	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG2_HUMAN
θ value	1.29631e-06 (rank : 62)	NC score	0.514879 (rank : 54)
Query Neighborhood Hits	205	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHGC_MOUSE
θ value	1.29631e-06 (rank : 63)	NC score	0.532423 (rank : 46)
Query Neighborhood Hits	205	Target Neighborhood Hits	344	Shared Neighborhood Hits	102
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

OBSCN_HUMAN
θ value	3.77169e-06 (rank : 64)	NC score	0.102782 (rank : 144)
Query Neighborhood Hits	205	Target Neighborhood Hits	1931	Shared Neighborhood Hits	71
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PSD3_HUMAN
θ value	1.43324e-05 (rank : 65)	NC score	0.141198 (rank : 95)
Query Neighborhood Hits	205	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
θ value	1.43324e-05 (rank : 66)	NC score	0.139562 (rank : 96)
Query Neighborhood Hits	205	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

ARHG5_HUMAN
θ value	1.87187e-05 (rank : 67)	NC score	0.573754 (rank : 24)
Query Neighborhood Hits	205	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

FGD6_MOUSE
θ value	3.19293e-05 (rank : 68)	NC score	0.475900 (rank : 56)
Query Neighborhood Hits	205	Target Neighborhood Hits	282	Shared Neighborhood Hits	82
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

LBC_HUMAN
θ value	4.1701e-05 (rank : 69)	NC score	0.524900 (rank : 50)
Query Neighborhood Hits	205	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

SPTB2_MOUSE
θ value	5.44631e-05 (rank : 70)	NC score	0.082968 (rank : 178)
Query Neighborhood Hits	205	Target Neighborhood Hits	770	Shared Neighborhood Hits	42
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FGD6_HUMAN
θ value	7.1131e-05 (rank : 71)	NC score	0.467731 (rank : 58)
Query Neighborhood Hits	205	Target Neighborhood Hits	237	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

SPTB2_HUMAN
θ value	9.29e-05 (rank : 72)	NC score	0.083943 (rank : 176)
Query Neighborhood Hits	205	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

FARP1_HUMAN
θ value	0.00020696 (rank : 73)	NC score	0.358548 (rank : 67)
Query Neighborhood Hits	205	Target Neighborhood Hits	241	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGF_HUMAN
θ value	0.000786445 (rank : 74)	NC score	0.517715 (rank : 53)
Query Neighborhood Hits	205	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

PDZK4_MOUSE
θ value	0.00102713 (rank : 75)	NC score	0.085469 (rank : 171)
Query Neighborhood Hits	205	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

RHG12_HUMAN
θ value	0.00134147 (rank : 76)	NC score	0.081361 (rank : 183)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

PSD4_HUMAN
θ value	0.00390308 (rank : 77)	NC score	0.118891 (rank : 116)
Query Neighborhood Hits	205	Target Neighborhood Hits	178	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SPTN2_HUMAN
θ value	0.00509761 (rank : 78)	NC score	0.078745 (rank : 191)
Query Neighborhood Hits	205	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

WHRN_HUMAN
θ value	0.00665767 (rank : 79)	NC score	0.105322 (rank : 139)
Query Neighborhood Hits	205	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

RHG12_MOUSE
θ value	0.0148317 (rank : 80)	NC score	0.072729 (rank : 206)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

LAP4_HUMAN
θ value	0.0193708 (rank : 81)	NC score	0.051346 (rank : 289)
Query Neighborhood Hits	205	Target Neighborhood Hits	608	Shared Neighborhood Hits	53
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

ACOT3_MOUSE
θ value	0.0252991 (rank : 82)	NC score	0.032451 (rank : 312)
Query Neighborhood Hits	205	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYR7, Q6Q2Z7	Gene names	Acot3, Pte1a, Pte2, Pte2a
Domain Architecture
Description	Acyl-coenzyme A thioesterase 3 (EC 3.1.2.2) (Acyl-CoA thioesterase 3) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (PTE-Ia).

TXLNB_HUMAN
θ value	0.0252991 (rank : 83)	NC score	0.045894 (rank : 305)
Query Neighborhood Hits	205	Target Neighborhood Hits	912	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

WHRN_MOUSE
θ value	0.0252991 (rank : 84)	NC score	0.102663 (rank : 145)
Query Neighborhood Hits	205	Target Neighborhood Hits	412	Shared Neighborhood Hits	52
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

MDN1_HUMAN
θ value	0.0431538 (rank : 85)	NC score	0.041007 (rank : 306)
Query Neighborhood Hits	205	Target Neighborhood Hits	662	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

PDZD3_HUMAN
θ value	0.0431538 (rank : 86)	NC score	0.098451 (rank : 150)
Query Neighborhood Hits	205	Target Neighborhood Hits	180	Shared Neighborhood Hits	44
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD7_HUMAN
θ value	0.0431538 (rank : 87)	NC score	0.106896 (rank : 137)
Query Neighborhood Hits	205	Target Neighborhood Hits	181	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

STAP1_MOUSE
θ value	0.0736092 (rank : 88)	NC score	0.076835 (rank : 196)
Query Neighborhood Hits	205	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

PZRN4_HUMAN
θ value	0.0961366 (rank : 89)	NC score	0.079507 (rank : 186)
Query Neighborhood Hits	205	Target Neighborhood Hits	438	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LAP4_MOUSE
θ value	0.125558 (rank : 90)	NC score	0.046302 (rank : 303)
Query Neighborhood Hits	205	Target Neighborhood Hits	590	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LIMK2_MOUSE
θ value	0.163984 (rank : 91)	NC score	0.008027 (rank : 354)
Query Neighborhood Hits	205	Target Neighborhood Hits	998	Shared Neighborhood Hits	31
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RGL1_HUMAN
θ value	0.163984 (rank : 92)	NC score	0.070984 (rank : 214)
Query Neighborhood Hits	205	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

CNKR1_HUMAN
θ value	0.21417 (rank : 93)	NC score	0.092954 (rank : 156)
Query Neighborhood Hits	205	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

MAGI1_HUMAN
θ value	0.21417 (rank : 94)	NC score	0.071462 (rank : 211)
Query Neighborhood Hits	205	Target Neighborhood Hits	388	Shared Neighborhood Hits	56
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

STAP1_HUMAN
θ value	0.365318 (rank : 95)	NC score	0.062032 (rank : 245)
Query Neighborhood Hits	205	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

ZO3_HUMAN
θ value	0.365318 (rank : 96)	NC score	0.075497 (rank : 198)
Query Neighborhood Hits	205	Target Neighborhood Hits	219	Shared Neighborhood Hits	43
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZO3_MOUSE
θ value	0.365318 (rank : 97)	NC score	0.069909 (rank : 218)
Query Neighborhood Hits	205	Target Neighborhood Hits	224	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

RGL1_MOUSE
θ value	0.47712 (rank : 98)	NC score	0.065864 (rank : 229)
Query Neighborhood Hits	205	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RHG25_MOUSE
θ value	0.47712 (rank : 99)	NC score	0.059585 (rank : 251)
Query Neighborhood Hits	205	Target Neighborhood Hits	492	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RPGF2_HUMAN
θ value	0.47712 (rank : 100)	NC score	0.086782 (rank : 164)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

UBP10_MOUSE
θ value	0.47712 (rank : 101)	NC score	0.018540 (rank : 333)
Query Neighborhood Hits	205	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

CNKR2_HUMAN
θ value	0.62314 (rank : 102)	NC score	0.071526 (rank : 210)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.62314 (rank : 103)	NC score	0.072077 (rank : 208)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ENPL_HUMAN
θ value	0.62314 (rank : 104)	NC score	0.017264 (rank : 335)
Query Neighborhood Hits	205	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

MAGI1_MOUSE
θ value	0.62314 (rank : 105)	NC score	0.065999 (rank : 228)
Query Neighborhood Hits	205	Target Neighborhood Hits	403	Shared Neighborhood Hits	54
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

NHRF2_MOUSE
θ value	0.62314 (rank : 106)	NC score	0.084544 (rank : 174)
Query Neighborhood Hits	205	Target Neighborhood Hits	194	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PAR6A_MOUSE
θ value	0.62314 (rank : 107)	NC score	0.051445 (rank : 288)
Query Neighborhood Hits	205	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PKHA2_MOUSE
θ value	0.62314 (rank : 108)	NC score	0.070948 (rank : 215)
Query Neighborhood Hits	205	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SOS2_HUMAN
θ value	0.62314 (rank : 109)	NC score	0.228758 (rank : 73)
Query Neighborhood Hits	205	Target Neighborhood Hits	193	Shared Neighborhood Hits	52
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

ZN206_HUMAN
θ value	0.62314 (rank : 110)	NC score	-0.004926 (rank : 376)
Query Neighborhood Hits	205	Target Neighborhood Hits	853	Shared Neighborhood Hits	8
SwissProt Accessions	Q96SZ4	Gene names	ZNF206, ZSCAN10
Domain Architecture	No domain graphic available
Description	Zinc finger protein 206 (Zinc finger and SCAN domain-containing protein 10).

PMS2_HUMAN
θ value	0.813845 (rank : 111)	NC score	0.021499 (rank : 328)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	P54278	Gene names	PMS2, PMSL2
Domain Architecture
Description	PMS1 protein homolog 2 (DNA mismatch repair protein PMS2).

SYN2_MOUSE
θ value	0.813845 (rank : 112)	NC score	0.023254 (rank : 324)
Query Neighborhood Hits	205	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

ZO1_HUMAN
θ value	0.813845 (rank : 113)	NC score	0.061219 (rank : 249)
Query Neighborhood Hits	205	Target Neighborhood Hits	474	Shared Neighborhood Hits	48
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	0.813845 (rank : 114)	NC score	0.062122 (rank : 244)
Query Neighborhood Hits	205	Target Neighborhood Hits	453	Shared Neighborhood Hits	45
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

FBXW7_HUMAN
θ value	1.06291 (rank : 115)	NC score	0.003012 (rank : 368)
Query Neighborhood Hits	205	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

MYO10_HUMAN
θ value	1.06291 (rank : 116)	NC score	0.024602 (rank : 319)
Query Neighborhood Hits	205	Target Neighborhood Hits	920	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NHRF2_HUMAN
θ value	1.06291 (rank : 117)	NC score	0.086597 (rank : 165)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	45
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PAR6A_HUMAN
θ value	1.06291 (rank : 118)	NC score	0.051927 (rank : 283)
Query Neighborhood Hits	205	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PKHA2_HUMAN
θ value	1.38821 (rank : 119)	NC score	0.063176 (rank : 240)
Query Neighborhood Hits	205	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SHAN2_MOUSE
θ value	1.38821 (rank : 120)	NC score	0.149242 (rank : 88)
Query Neighborhood Hits	205	Target Neighborhood Hits	446	Shared Neighborhood Hits	61
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

2DOB_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.006810 (rank : 357)
Query Neighborhood Hits	205	Target Neighborhood Hits	201	Shared Neighborhood Hits	3
SwissProt Accessions	P13765, Q29746, Q29825	Gene names	HLA-DOB
Domain Architecture
Description	HLA class II histocompatibility antigen, DO beta chain precursor (MHC class II antigen DOB).

CSPG5_HUMAN
θ value	1.81305 (rank : 122)	NC score	0.019230 (rank : 331)
Query Neighborhood Hits	205	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

SHAN2_HUMAN
θ value	1.81305 (rank : 123)	NC score	0.067502 (rank : 222)
Query Neighborhood Hits	205	Target Neighborhood Hits	346	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

TXLNB_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.033986 (rank : 311)
Query Neighborhood Hits	205	Target Neighborhood Hits	640	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

ACOT1_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.023699 (rank : 323)
Query Neighborhood Hits	205	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

AP3B1_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.022312 (rank : 326)
Query Neighborhood Hits	205	Target Neighborhood Hits	302	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CAMKV_HUMAN
θ value	2.36792 (rank : 127)	NC score	0.009405 (rank : 348)
Query Neighborhood Hits	205	Target Neighborhood Hits	1084	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

DMD_MOUSE
θ value	2.36792 (rank : 128)	NC score	0.039449 (rank : 307)
Query Neighborhood Hits	205	Target Neighborhood Hits	1111	Shared Neighborhood Hits	33
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

KAP1_HUMAN
θ value	2.36792 (rank : 129)	NC score	0.009288 (rank : 349)
Query Neighborhood Hits	205	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

LIMK1_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.004895 (rank : 361)
Query Neighborhood Hits	205	Target Neighborhood Hits	1005	Shared Neighborhood Hits	29
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MLL2_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.030329 (rank : 314)
Query Neighborhood Hits	205	Target Neighborhood Hits	1788	Shared Neighborhood Hits	44
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PLEK2_MOUSE
θ value	2.36792 (rank : 132)	NC score	0.051165 (rank : 291)
Query Neighborhood Hits	205	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

SHAN1_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.109024 (rank : 133)
Query Neighborhood Hits	205	Target Neighborhood Hits	1041	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ACOT2_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.024254 (rank : 322)
Query Neighborhood Hits	205	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

ADA2A_MOUSE
θ value	3.0926 (rank : 135)	NC score	-0.003651 (rank : 375)
Query Neighborhood Hits	205	Target Neighborhood Hits	900	Shared Neighborhood Hits	4
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

AKA12_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.012527 (rank : 344)
Query Neighborhood Hits	205	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

APBA3_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.051170 (rank : 290)
Query Neighborhood Hits	205	Target Neighborhood Hits	201	Shared Neighborhood Hits	45
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

CD016_HUMAN
θ value	3.0926 (rank : 138)	NC score	0.025106 (rank : 318)
Query Neighborhood Hits	205	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q63HQ0, Q96GG6, Q9H0V0, Q9P1L4	Gene names	C4orf16
Domain Architecture	No domain graphic available
Description	Protein C4orf16.

LNX2_HUMAN
θ value	3.0926 (rank : 139)	NC score	0.051669 (rank : 285)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

PDZD1_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.079394 (rank : 188)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PLEK2_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.046182 (rank : 304)
Query Neighborhood Hits	205	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

SCN2A_HUMAN
θ value	3.0926 (rank : 142)	NC score	0.004696 (rank : 362)
Query Neighborhood Hits	205	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SDCB2_HUMAN
θ value	3.0926 (rank : 143)	NC score	0.036404 (rank : 309)
Query Neighborhood Hits	205	Target Neighborhood Hits	121	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

THAP4_HUMAN
θ value	3.0926 (rank : 144)	NC score	0.013912 (rank : 342)
Query Neighborhood Hits	205	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY91, Q53NU7, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325	Gene names	THAP4
Domain Architecture
Description	THAP domain-containing protein 4.

TRPS1_MOUSE
θ value	3.0926 (rank : 145)	NC score	0.006915 (rank : 355)
Query Neighborhood Hits	205	Target Neighborhood Hits	609	Shared Neighborhood Hits	6
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

AFF1_MOUSE
θ value	4.03905 (rank : 146)	NC score	0.016058 (rank : 339)
Query Neighborhood Hits	205	Target Neighborhood Hits	351	Shared Neighborhood Hits	15
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

GOGB1_HUMAN
θ value	4.03905 (rank : 147)	NC score	0.034749 (rank : 310)
Query Neighborhood Hits	205	Target Neighborhood Hits	2297	Shared Neighborhood Hits	64
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HDAC7_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.006463 (rank : 358)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

LNX2_MOUSE
θ value	4.03905 (rank : 149)	NC score	0.052756 (rank : 281)
Query Neighborhood Hits	205	Target Neighborhood Hits	407	Shared Neighborhood Hits	43
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MUC13_MOUSE
θ value	4.03905 (rank : 150)	NC score	0.020243 (rank : 330)
Query Neighborhood Hits	205	Target Neighborhood Hits	447	Shared Neighborhood Hits	8
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

PDZD1_MOUSE
θ value	4.03905 (rank : 151)	NC score	0.082027 (rank : 180)
Query Neighborhood Hits	205	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PKHA5_HUMAN
θ value	4.03905 (rank : 152)	NC score	0.064129 (rank : 236)
Query Neighborhood Hits	205	Target Neighborhood Hits	455	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PO2F1_MOUSE
θ value	4.03905 (rank : 153)	NC score	0.003455 (rank : 366)
Query Neighborhood Hits	205	Target Neighborhood Hits	408	Shared Neighborhood Hits	8
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

RHG25_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.046826 (rank : 302)
Query Neighborhood Hits	205	Target Neighborhood Hits	550	Shared Neighborhood Hits	39
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SAMD9_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.022283 (rank : 327)
Query Neighborhood Hits	205	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

A4_MOUSE
θ value	5.27518 (rank : 156)	NC score	0.018802 (rank : 332)
Query Neighborhood Hits	205	Target Neighborhood Hits	275	Shared Neighborhood Hits	14
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

CE290_HUMAN
θ value	5.27518 (rank : 157)	NC score	0.028749 (rank : 315)
Query Neighborhood Hits	205	Target Neighborhood Hits	1553	Shared Neighborhood Hits	37
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CO8B_HUMAN
θ value	5.27518 (rank : 158)	NC score	0.004642 (rank : 363)
Query Neighborhood Hits	205	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

DYN3_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.016641 (rank : 336)
Query Neighborhood Hits	205	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

K1543_MOUSE
θ value	5.27518 (rank : 160)	NC score	0.013708 (rank : 343)
Query Neighborhood Hits	205	Target Neighborhood Hits	497	Shared Neighborhood Hits	20
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

KRHB6_MOUSE
θ value	5.27518 (rank : 161)	NC score	0.000937 (rank : 371)
Query Neighborhood Hits	205	Target Neighborhood Hits	413	Shared Neighborhood Hits	12
SwissProt Accessions	P97861, Q3TTV9	Gene names	Krthb6, Krt2-10
Domain Architecture	No domain graphic available
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6).

LCP2_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.015689 (rank : 340)
Query Neighborhood Hits	205	Target Neighborhood Hits	531	Shared Neighborhood Hits	18
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MIER1_MOUSE
θ value	5.27518 (rank : 163)	NC score	0.014910 (rank : 341)
Query Neighborhood Hits	205	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q5UAK0, Q5UAK1, Q5UAK2, Q5UAK3, Q6ZPL6, Q9D402	Gene names	Mier1, Kiaa1610
Domain Architecture	No domain graphic available
Description	Mesoderm induction early response protein 1 (Mi-er1).

NPAS3_HUMAN
θ value	5.27518 (rank : 164)	NC score	0.008526 (rank : 351)
Query Neighborhood Hits	205	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	5.27518 (rank : 165)	NC score	0.008093 (rank : 353)
Query Neighborhood Hits	205	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PARD3_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.055775 (rank : 266)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PARD3_MOUSE
θ value	5.27518 (rank : 167)	NC score	0.055877 (rank : 264)
Query Neighborhood Hits	205	Target Neighborhood Hits	290	Shared Neighborhood Hits	47
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDZD3_MOUSE
θ value	5.27518 (rank : 168)	NC score	0.076206 (rank : 197)
Query Neighborhood Hits	205	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

RBNS5_HUMAN
θ value	5.27518 (rank : 169)	NC score	0.064873 (rank : 233)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RFIP3_HUMAN
θ value	5.27518 (rank : 170)	NC score	0.032245 (rank : 313)
Query Neighborhood Hits	205	Target Neighborhood Hits	1055	Shared Neighborhood Hits	35
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RIMS2_HUMAN
θ value	5.27518 (rank : 171)	NC score	0.024374 (rank : 321)
Query Neighborhood Hits	205	Target Neighborhood Hits	342	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	5.27518 (rank : 172)	NC score	0.024581 (rank : 320)
Query Neighborhood Hits	205	Target Neighborhood Hits	376	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

ADA2A_HUMAN
θ value	6.88961 (rank : 173)	NC score	-0.002910 (rank : 374)
Query Neighborhood Hits	205	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

AP3B2_MOUSE
θ value	6.88961 (rank : 174)	NC score	0.008639 (rank : 350)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

ATBF1_HUMAN
θ value	6.88961 (rank : 175)	NC score	-0.000321 (rank : 373)
Query Neighborhood Hits	205	Target Neighborhood Hits	1547	Shared Neighborhood Hits	21
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

FA76A_MOUSE
θ value	6.88961 (rank : 176)	NC score	0.008318 (rank : 352)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q922G2, Q3U3U8, Q3V3N2	Gene names	Fam76a
Domain Architecture	No domain graphic available
Description	Protein FAM76A.

FLIP1_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.037586 (rank : 308)
Query Neighborhood Hits	205	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

LPHN2_HUMAN
θ value	6.88961 (rank : 178)	NC score	0.001457 (rank : 369)
Query Neighborhood Hits	205	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

PP16B_HUMAN
θ value	6.88961 (rank : 179)	NC score	-0.000155 (rank : 372)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PPR3A_HUMAN
θ value	6.88961 (rank : 180)	NC score	0.009742 (rank : 346)
Query Neighborhood Hits	205	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q16821, O43476, Q75LN8, Q7KYM8, Q86UI6	Gene names	PPP1R3A, PP1G
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit).

REST_MOUSE
θ value	6.88961 (rank : 181)	NC score	0.026838 (rank : 316)
Query Neighborhood Hits	205	Target Neighborhood Hits	1506	Shared Neighborhood Hits	40
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RPGF6_HUMAN
θ value	6.88961 (rank : 182)	NC score	0.079484 (rank : 187)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TEX2_HUMAN
θ value	6.88961 (rank : 183)	NC score	0.022576 (rank : 325)
Query Neighborhood Hits	205	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

TNR8_HUMAN
θ value	6.88961 (rank : 184)	NC score	0.006878 (rank : 356)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

ABCA9_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.001203 (rank : 370)
Query Neighborhood Hits	205	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

CBLB_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.003829 (rank : 365)
Query Neighborhood Hits	205	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CCD38_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.020780 (rank : 329)
Query Neighborhood Hits	205	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDN8, Q8CDD6, Q8CDE1	Gene names	Ccdc38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

DDEF2_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.068319 (rank : 220)
Query Neighborhood Hits	205	Target Neighborhood Hits	599	Shared Neighborhood Hits	37
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DLG5_HUMAN
θ value	8.99809 (rank : 189)	NC score	0.047728 (rank : 301)
Query Neighborhood Hits	205	Target Neighborhood Hits	1088	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DYN2_HUMAN
θ value	8.99809 (rank : 190)	NC score	0.016512 (rank : 337)
Query Neighborhood Hits	205	Target Neighborhood Hits	112	Shared Neighborhood Hits	16
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	8.99809 (rank : 191)	NC score	0.016421 (rank : 338)
Query Neighborhood Hits	205	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

FGD5_MOUSE
θ value	8.99809 (rank : 192)	NC score	0.292570 (rank : 70)
Query Neighborhood Hits	205	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GRIP1_MOUSE
θ value	8.99809 (rank : 193)	NC score	0.049803 (rank : 300)
Query Neighborhood Hits	205	Target Neighborhood Hits	241	Shared Neighborhood Hits	51
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LIMK2_HUMAN
θ value	8.99809 (rank : 194)	NC score	0.005299 (rank : 359)
Query Neighborhood Hits	205	Target Neighborhood Hits	986	Shared Neighborhood Hits	31
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MPDZ_HUMAN
θ value	8.99809 (rank : 195)	NC score	0.053478 (rank : 274)
Query Neighborhood Hits	205	Target Neighborhood Hits	261	Shared Neighborhood Hits	50
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MYH9_HUMAN
θ value	8.99809 (rank : 196)	NC score	0.018353 (rank : 334)
Query Neighborhood Hits	205	Target Neighborhood Hits	1762	Shared Neighborhood Hits	45
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NUP62_MOUSE
θ value	8.99809 (rank : 197)	NC score	0.009700 (rank : 347)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q63850, Q99JN7	Gene names	Nup62
Domain Architecture
Description	Nuclear pore glycoprotein p62 (62 kDa nucleoporin).

OS9_HUMAN
θ value	8.99809 (rank : 198)	NC score	0.010995 (rank : 345)
Query Neighborhood Hits	205	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

PDE4B_HUMAN
θ value	8.99809 (rank : 199)	NC score	0.003329 (rank : 367)
Query Neighborhood Hits	205	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PININ_HUMAN
θ value	8.99809 (rank : 200)	NC score	0.025850 (rank : 317)
Query Neighborhood Hits	205	Target Neighborhood Hits	753	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PKHA4_MOUSE
θ value	8.99809 (rank : 201)	NC score	0.054782 (rank : 271)
Query Neighborhood Hits	205	Target Neighborhood Hits	202	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RIPK5_HUMAN
θ value	8.99809 (rank : 202)	NC score	0.004959 (rank : 360)
Query Neighborhood Hits	205	Target Neighborhood Hits	864	Shared Neighborhood Hits	13
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	8.99809 (rank : 203)	NC score	0.004572 (rank : 364)
Query Neighborhood Hits	205	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ZO2_HUMAN
θ value	8.99809 (rank : 204)	NC score	0.054462 (rank : 273)
Query Neighborhood Hits	205	Target Neighborhood Hits	289	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	8.99809 (rank : 205)	NC score	0.053411 (rank : 275)
Query Neighborhood Hits	205	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ABI1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.109447 (rank : 131)
Query Neighborhood Hits	205	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.116489 (rank : 120)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.123019 (rank : 107)
Query Neighborhood Hits	205	Target Neighborhood Hits	350	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.122249 (rank : 111)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.102031 (rank : 146)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.098496 (rank : 149)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.102866 (rank : 142)
Query Neighborhood Hits	205	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.099517 (rank : 148)
Query Neighborhood Hits	205	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.090017 (rank : 160)
Query Neighborhood Hits	205	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.083071 (rank : 177)
Query Neighborhood Hits	205	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ASPP1_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.061748 (rank : 247)
Query Neighborhood Hits	205	Target Neighborhood Hits	956	Shared Neighborhood Hits	35
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.064034 (rank : 237)
Query Neighborhood Hits	205	Target Neighborhood Hits	1244	Shared Neighborhood Hits	45
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAIP2_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.064487 (rank : 234)
Query Neighborhood Hits	205	Target Neighborhood Hits	192	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.066226 (rank : 227)
Query Neighborhood Hits	205	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.082126 (rank : 179)
Query Neighborhood Hits	205	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.084667 (rank : 172)
Query Neighborhood Hits	205	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCR_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.323962 (rank : 68)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.109432 (rank : 132)
Query Neighborhood Hits	205	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.085990 (rank : 168)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.081288 (rank : 184)
Query Neighborhood Hits	205	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.077222 (rank : 194)
Query Neighborhood Hits	205	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.176608 (rank : 78)
Query Neighborhood Hits	205	Target Neighborhood Hits	315	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.175812 (rank : 79)
Query Neighborhood Hits	205	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNN1_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.055763 (rank : 267)
Query Neighborhood Hits	205	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN1_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.055679 (rank : 269)
Query Neighborhood Hits	205	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN2_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.051479 (rank : 287)
Query Neighborhood Hits	205	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN2_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.054989 (rank : 270)
Query Neighborhood Hits	205	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

CNN3_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.052816 (rank : 280)
Query Neighborhood Hits	205	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.052936 (rank : 279)
Query Neighborhood Hits	205	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CRKL_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.120327 (rank : 114)
Query Neighborhood Hits	205	Target Neighborhood Hits	313	Shared Neighborhood Hits	26
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.117682 (rank : 118)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.109742 (rank : 130)
Query Neighborhood Hits	205	Target Neighborhood Hits	308	Shared Neighborhood Hits	26
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.112466 (rank : 126)
Query Neighborhood Hits	205	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.085754 (rank : 169)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.100130 (rank : 147)
Query Neighborhood Hits	205	Target Neighborhood Hits	244	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.097018 (rank : 153)
Query Neighborhood Hits	205	Target Neighborhood Hits	306	Shared Neighborhood Hits	27
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.061984 (rank : 246)
Query Neighborhood Hits	205	Target Neighborhood Hits	592	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.066397 (rank : 226)
Query Neighborhood Hits	205	Target Neighborhood Hits	625	Shared Neighborhood Hits	35
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DLG2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.050626 (rank : 296)
Query Neighborhood Hits	205	Target Neighborhood Hits	279	Shared Neighborhood Hits	55
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

EFS_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.071004 (rank : 213)
Query Neighborhood Hits	205	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.073256 (rank : 204)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ES8L3_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.050306 (rank : 298)
Query Neighborhood Hits	205	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGD5_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.312283 (rank : 69)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FNBP2_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.073528 (rank : 202)
Query Neighborhood Hits	205	Target Neighborhood Hits	432	Shared Neighborhood Hits	34
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRAP2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.122615 (rank : 108)
Query Neighborhood Hits	205	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.122499 (rank : 109)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.146312 (rank : 91)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.145122 (rank : 92)
Query Neighborhood Hits	205	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.134005 (rank : 98)
Query Neighborhood Hits	205	Target Neighborhood Hits	310	Shared Neighborhood Hits	27
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.133997 (rank : 99)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.073282 (rank : 203)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.122006 (rank : 112)
Query Neighborhood Hits	205	Target Neighborhood Hits	358	Shared Neighborhood Hits	30
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.124446 (rank : 104)
Query Neighborhood Hits	205	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.057932 (rank : 257)
Query Neighborhood Hits	205	Target Neighborhood Hits	517	Shared Neighborhood Hits	27
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.058068 (rank : 255)
Query Neighborhood Hits	205	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.065574 (rank : 231)
Query Neighborhood Hits	205	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.066971 (rank : 224)
Query Neighborhood Hits	205	Target Neighborhood Hits	1024	Shared Neighborhood Hits	32
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

INADL_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.051848 (rank : 284)
Query Neighborhood Hits	205	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.053052 (rank : 277)
Query Neighborhood Hits	205	Target Neighborhood Hits	290	Shared Neighborhood Hits	50
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

LASP1_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.088722 (rank : 162)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.086307 (rank : 167)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	26
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LIN7B_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.050758 (rank : 294)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.051133 (rank : 292)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LMO7_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.084587 (rank : 173)
Query Neighborhood Hits	205	Target Neighborhood Hits	507	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MAGI2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.050150 (rank : 299)
Query Neighborhood Hits	205	Target Neighborhood Hits	373	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.050758 (rank : 295)
Query Neighborhood Hits	205	Target Neighborhood Hits	370	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MIA_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.057157 (rank : 260)
Query Neighborhood Hits	205	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MIA_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.057307 (rank : 259)
Query Neighborhood Hits	205	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MYO1E_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.056228 (rank : 262)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	31
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.055809 (rank : 265)
Query Neighborhood Hits	205	Target Neighborhood Hits	275	Shared Neighborhood Hits	28
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.056751 (rank : 261)
Query Neighborhood Hits	205	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.188173 (rank : 76)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.174190 (rank : 81)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.158074 (rank : 84)
Query Neighborhood Hits	205	Target Neighborhood Hits	229	Shared Neighborhood Hits	27
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.147459 (rank : 89)
Query Neighborhood Hits	205	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.146496 (rank : 90)
Query Neighborhood Hits	205	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.150098 (rank : 87)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.144502 (rank : 93)
Query Neighborhood Hits	205	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.081593 (rank : 182)
Query Neighborhood Hits	205	Target Neighborhood Hits	457	Shared Neighborhood Hits	30
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.072598 (rank : 207)
Query Neighborhood Hits	205	Target Neighborhood Hits	420	Shared Neighborhood Hits	28
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NHERF_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.067476 (rank : 223)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.063383 (rank : 239)
Query Neighborhood Hits	205	Target Neighborhood Hits	195	Shared Neighborhood Hits	43
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NOXO1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.084362 (rank : 175)
Query Neighborhood Hits	205	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.092196 (rank : 158)
Query Neighborhood Hits	205	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.077129 (rank : 195)
Query Neighborhood Hits	205	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.093873 (rank : 155)
Query Neighborhood Hits	205	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.103669 (rank : 141)
Query Neighborhood Hits	205	Target Neighborhood Hits	466	Shared Neighborhood Hits	28
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.102784 (rank : 143)
Query Neighborhood Hits	205	Target Neighborhood Hits	467	Shared Neighborhood Hits	27
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.062434 (rank : 243)
Query Neighborhood Hits	205	Target Neighborhood Hits	479	Shared Neighborhood Hits	27
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.061304 (rank : 248)
Query Neighborhood Hits	205	Target Neighborhood Hits	435	Shared Neighborhood Hits	24
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.059302 (rank : 252)
Query Neighborhood Hits	205	Target Neighborhood Hits	543	Shared Neighborhood Hits	28
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.054711 (rank : 272)
Query Neighborhood Hits	205	Target Neighborhood Hits	519	Shared Neighborhood Hits	26
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.079084 (rank : 190)
Query Neighborhood Hits	205	Target Neighborhood Hits	320	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.077621 (rank : 193)
Query Neighborhood Hits	205	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.085492 (rank : 170)
Query Neighborhood Hits	205	Target Neighborhood Hits	339	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.086421 (rank : 166)
Query Neighborhood Hits	205	Target Neighborhood Hits	382	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.080001 (rank : 185)
Query Neighborhood Hits	205	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.081761 (rank : 181)
Query Neighborhood Hits	205	Target Neighborhood Hits	380	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PAR3L_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.050340 (rank : 297)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PEX13_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.089073 (rank : 161)
Query Neighborhood Hits	205	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.091893 (rank : 159)
Query Neighborhood Hits	205	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA6_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.071578 (rank : 209)
Query Neighborhood Hits	205	Target Neighborhood Hits	556	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.070726 (rank : 216)
Query Neighborhood Hits	205	Target Neighborhood Hits	591	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.115162 (rank : 121)
Query Neighborhood Hits	205	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.113303 (rank : 125)
Query Neighborhood Hits	205	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.123099 (rank : 106)
Query Neighborhood Hits	205	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.122480 (rank : 110)
Query Neighborhood Hits	205	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCG1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.107309 (rank : 136)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	26
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.108395 (rank : 134)
Query Neighborhood Hits	205	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.095349 (rank : 154)
Query Neighborhood Hits	205	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLEK_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.053023 (rank : 278)
Query Neighborhood Hits	205	Target Neighborhood Hits	110	Shared Neighborhood Hits	29
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PPIP1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.114636 (rank : 123)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	32
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.110913 (rank : 127)
Query Neighborhood Hits	205	Target Neighborhood Hits	377	Shared Neighborhood Hits	31
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RBNS5_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.056100 (rank : 263)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

REPS1_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.055693 (rank : 268)
Query Neighborhood Hits	205	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS1_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.058487 (rank : 253)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

REPS2_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.065309 (rank : 232)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

REPS2_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.066674 (rank : 225)
Query Neighborhood Hits	205	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.092894 (rank : 157)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.073164 (rank : 205)
Query Neighborhood Hits	205	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIMB1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.051652 (rank : 286)
Query Neighborhood Hits	205	Target Neighborhood Hits	1479	Shared Neighborhood Hits	51
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.079326 (rank : 189)
Query Neighborhood Hits	205	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.077834 (rank : 192)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC1_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.052356 (rank : 282)
Query Neighborhood Hits	205	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SH3G1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.114282 (rank : 124)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.110751 (rank : 128)
Query Neighborhood Hits	205	Target Neighborhood Hits	291	Shared Neighborhood Hits	28
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.109832 (rank : 129)
Query Neighborhood Hits	205	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.108075 (rank : 135)
Query Neighborhood Hits	205	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.114666 (rank : 122)
Query Neighborhood Hits	205	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.117550 (rank : 119)
Query Neighborhood Hits	205	Target Neighborhood Hits	236	Shared Neighborhood Hits	25
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.186901 (rank : 77)
Query Neighborhood Hits	205	Target Neighborhood Hits	341	Shared Neighborhood Hits	32
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.175063 (rank : 80)
Query Neighborhood Hits	205	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SNX18_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.060602 (rank : 250)
Query Neighborhood Hits	205	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.062782 (rank : 241)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX9_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.053272 (rank : 276)
Query Neighborhood Hits	205	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SOS1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.236721 (rank : 71)
Query Neighborhood Hits	205	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.227009 (rank : 74)
Query Neighborhood Hits	205	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.097940 (rank : 151)
Query Neighborhood Hits	205	Target Neighborhood Hits	748	Shared Neighborhood Hits	41
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.104898 (rank : 140)
Query Neighborhood Hits	205	Target Neighborhood Hits	675	Shared Neighborhood Hits	38
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.105980 (rank : 138)
Query Neighborhood Hits	205	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTN4_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.058436 (rank : 254)
Query Neighborhood Hits	205	Target Neighborhood Hits	570	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTN5_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.050859 (rank : 293)
Query Neighborhood Hits	205	Target Neighborhood Hits	674	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

SRBS1_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.158503 (rank : 83)
Query Neighborhood Hits	205	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.159252 (rank : 82)
Query Neighborhood Hits	205	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.123635 (rank : 105)
Query Neighborhood Hits	205	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.121571 (rank : 113)
Query Neighborhood Hits	205	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.075396 (rank : 199)
Query Neighborhood Hits	205	Target Neighborhood Hits	390	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.074269 (rank : 201)
Query Neighborhood Hits	205	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.074996 (rank : 200)
Query Neighborhood Hits	205	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.127491 (rank : 101)
Query Neighborhood Hits	205	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.128553 (rank : 100)
Query Neighborhood Hits	205	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.141386 (rank : 94)
Query Neighborhood Hits	205	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 358)	NC score	0.137003 (rank : 97)
Query Neighborhood Hits	205	Target Neighborhood Hits	268	Shared Neighborhood Hits	27
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.126752 (rank : 102)
Query Neighborhood Hits	205	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.125511 (rank : 103)
Query Neighborhood Hits	205	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.118681 (rank : 117)
Query Neighborhood Hits	205	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 362)	NC score	0.120036 (rank : 115)
Query Neighborhood Hits	205	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.087890 (rank : 163)
Query Neighborhood Hits	205	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.097776 (rank : 152)
Query Neighborhood Hits	205	Target Neighborhood Hits	409	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TX1B3_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.057908 (rank : 258)
Query Neighborhood Hits	205	Target Neighborhood Hits	161	Shared Neighborhood Hits	41
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.058008 (rank : 256)
Query Neighborhood Hits	205	Target Neighborhood Hits	158	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.070700 (rank : 217)
Query Neighborhood Hits	205	Target Neighborhood Hits	327	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.068004 (rank : 221)
Query Neighborhood Hits	205	Target Neighborhood Hits	557	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

VINEX_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.152225 (rank : 86)
Query Neighborhood Hits	205	Target Neighborhood Hits	270	Shared Neighborhood Hits	30
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.153160 (rank : 85)
Query Neighborhood Hits	205	Target Neighborhood Hits	286	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ZFY16_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.063631 (rank : 238)
Query Neighborhood Hits	205	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.065782 (rank : 230)
Query Neighborhood Hits	205	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.062447 (rank : 242)
Query Neighborhood Hits	205	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.064402 (rank : 235)
Query Neighborhood Hits	205	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.071221 (rank : 212)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.069312 (rank : 219)
Query Neighborhood Hits	205	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

TIAM1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	205	Target Neighborhood Hits	205	Shared Neighborhood Hits	205
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_HUMAN
NC score	0.989147 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	205	Target Neighborhood Hits	225	Shared Neighborhood Hits	157
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHG1_HUMAN
NC score	0.760973 (rank : 3)	θ value	4.01107e-24 (rank : 6)
Query Neighborhood Hits	205	Target Neighborhood Hits	174	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PREX1_HUMAN
NC score	0.744504 (rank : 4)	θ value	3.62785e-25 (rank : 5)
Query Neighborhood Hits	205	Target Neighborhood Hits	177	Shared Neighborhood Hits	88
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_MOUSE
NC score	0.740361 (rank : 5)	θ value	3.88503e-19 (rank : 7)
Query Neighborhood Hits	205	Target Neighborhood Hits	185	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
NC score	0.733744 (rank : 6)	θ value	2.51237e-26 (rank : 4)
Query Neighborhood Hits	205	Target Neighborhood Hits	234	Shared Neighborhood Hits	72
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.733611 (rank : 7)	θ value	2.51237e-26 (rank : 3)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	72
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG4_HUMAN
NC score	0.713022 (rank : 8)	θ value	2.5182e-18 (rank : 9)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG3_HUMAN
NC score	0.682697 (rank : 9)	θ value	4.59992e-12 (rank : 30)
Query Neighborhood Hits	205	Target Neighborhood Hits	82	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.681076 (rank : 10)	θ value	7.84624e-12 (rank : 31)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

MCF2_HUMAN
NC score	0.670910 (rank : 11)	θ value	1.2105e-12 (rank : 27)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ECT2_MOUSE
NC score	0.667666 (rank : 12)	θ value	2.69671e-12 (rank : 28)
Query Neighborhood Hits	205	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG8_HUMAN
NC score	0.667471 (rank : 13)	θ value	3.89403e-11 (rank : 35)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ECT2_HUMAN
NC score	0.652932 (rank : 14)	θ value	7.84624e-12 (rank : 33)
Query Neighborhood Hits	205	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

MCF2L_MOUSE
NC score	0.650670 (rank : 15)	θ value	2.43908e-13 (rank : 25)
Query Neighborhood Hits	205	Target Neighborhood Hits	255	Shared Neighborhood Hits	75
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG8_MOUSE
NC score	0.650528 (rank : 16)	θ value	2.79066e-09 (rank : 41)
Query Neighborhood Hits	205	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGG_MOUSE
NC score	0.628362 (rank : 17)	θ value	6.41864e-14 (rank : 21)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	68
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_HUMAN
NC score	0.622988 (rank : 18)	θ value	6.64225e-11 (rank : 36)
Query Neighborhood Hits	205	Target Neighborhood Hits	129	Shared Neighborhood Hits	70
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

FGD3_MOUSE
NC score	0.595371 (rank : 19)	θ value	5.26297e-08 (rank : 51)
Query Neighborhood Hits	205	Target Neighborhood Hits	257	Shared Neighborhood Hits	73
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ARHGB_HUMAN
NC score	0.580528 (rank : 20)	θ value	9.59137e-10 (rank : 38)
Query Neighborhood Hits	205	Target Neighborhood Hits	375	Shared Neighborhood Hits	106
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

NGEF_HUMAN
NC score	0.576341 (rank : 21)	θ value	7.59969e-07 (rank : 60)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG1_HUMAN
NC score	0.575494 (rank : 22)	θ value	4.76016e-09 (rank : 43)
Query Neighborhood Hits	205	Target Neighborhood Hits	176	Shared Neighborhood Hits	63
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

DNMBP_MOUSE
NC score	0.574924 (rank : 23)	θ value	3.40345e-15 (rank : 17)
Query Neighborhood Hits	205	Target Neighborhood Hits	435	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG5_HUMAN
NC score	0.573754 (rank : 24)	θ value	1.87187e-05 (rank : 67)
Query Neighborhood Hits	205	Target Neighborhood Hits	172	Shared Neighborhood Hits	76
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG7_HUMAN
NC score	0.572125 (rank : 25)	θ value	9.90251e-15 (rank : 19)
Query Neighborhood Hits	205	Target Neighborhood Hits	347	Shared Neighborhood Hits	76
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

FGD2_HUMAN
NC score	0.571733 (rank : 26)	θ value	2.13673e-09 (rank : 40)
Query Neighborhood Hits	205	Target Neighborhood Hits	151	Shared Neighborhood Hits	72
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHG7_MOUSE
NC score	0.571531 (rank : 27)	θ value	4.44505e-15 (rank : 18)
Query Neighborhood Hits	205	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

FGD4_MOUSE
NC score	0.570469 (rank : 28)	θ value	6.21693e-09 (rank : 45)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

HAPIP_HUMAN
NC score	0.569532 (rank : 29)	θ value	1.16975e-15 (rank : 14)
Query Neighborhood Hits	205	Target Neighborhood Hits	350	Shared Neighborhood Hits	80
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

FGD4_HUMAN
NC score	0.569418 (rank : 30)	θ value	4.0297e-08 (rank : 48)
Query Neighborhood Hits	205	Target Neighborhood Hits	219	Shared Neighborhood Hits	78
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHGA_HUMAN
NC score	0.569298 (rank : 31)	θ value	8.97725e-08 (rank : 52)
Query Neighborhood Hits	205	Target Neighborhood Hits	187	Shared Neighborhood Hits	68
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

NGEF_MOUSE
NC score	0.568599 (rank : 32)	θ value	7.59969e-07 (rank : 61)
Query Neighborhood Hits	205	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD2_MOUSE
NC score	0.568474 (rank : 33)	θ value	9.59137e-10 (rank : 39)
Query Neighborhood Hits	205	Target Neighborhood Hits	163	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
NC score	0.567255 (rank : 34)	θ value	8.97725e-08 (rank : 53)
Query Neighborhood Hits	205	Target Neighborhood Hits	249	Shared Neighborhood Hits	72
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ARHGA_MOUSE
NC score	0.565219 (rank : 35)	θ value	7.59969e-07 (rank : 59)
Query Neighborhood Hits	205	Target Neighborhood Hits	125	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

DNMBP_HUMAN
NC score	0.558554 (rank : 36)	θ value	8.38298e-14 (rank : 22)
Query Neighborhood Hits	205	Target Neighborhood Hits	413	Shared Neighborhood Hits	78
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_HUMAN
NC score	0.551723 (rank : 37)	θ value	3.18553e-13 (rank : 26)
Query Neighborhood Hits	205	Target Neighborhood Hits	376	Shared Neighborhood Hits	68
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

PKHG4_HUMAN
NC score	0.541242 (rank : 38)	θ value	4.76016e-09 (rank : 44)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	57
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ARHGC_HUMAN
NC score	0.540782 (rank : 39)	θ value	4.45536e-07 (rank : 57)
Query Neighborhood Hits	205	Target Neighborhood Hits	351	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHG6_MOUSE
NC score	0.539981 (rank : 40)	θ value	1.42992e-13 (rank : 24)
Query Neighborhood Hits	205	Target Neighborhood Hits	394	Shared Neighborhood Hits	66
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

VAV_MOUSE
NC score	0.538864 (rank : 41)	θ value	2.60593e-15 (rank : 16)
Query Neighborhood Hits	205	Target Neighborhood Hits	430	Shared Neighborhood Hits	76
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG2_MOUSE
NC score	0.537625 (rank : 42)	θ value	7.59969e-07 (rank : 58)
Query Neighborhood Hits	205	Target Neighborhood Hits	120	Shared Neighborhood Hits	65
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FGD1_MOUSE
NC score	0.536563 (rank : 43)	θ value	3.08544e-08 (rank : 47)
Query Neighborhood Hits	205	Target Neighborhood Hits	387	Shared Neighborhood Hits	77
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.535634 (rank : 44)	θ value	5.26297e-08 (rank : 50)
Query Neighborhood Hits	205	Target Neighborhood Hits	367	Shared Neighborhood Hits	75
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARHG1_MOUSE
NC score	0.533093 (rank : 45)	θ value	3.64472e-09 (rank : 42)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGC_MOUSE
NC score	0.532423 (rank : 46)	θ value	1.29631e-06 (rank : 63)
Query Neighborhood Hits	205	Target Neighborhood Hits	344	Shared Neighborhood Hits	102
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

VAV2_HUMAN
NC score	0.530335 (rank : 47)	θ value	3.52202e-12 (rank : 29)
Query Neighborhood Hits	205	Target Neighborhood Hits	453	Shared Neighborhood Hits	71
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.527117 (rank : 48)	θ value	7.84624e-12 (rank : 34)
Query Neighborhood Hits	205	Target Neighborhood Hits	456	Shared Neighborhood Hits	71
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
NC score	0.527058 (rank : 49)	θ value	2.60593e-15 (rank : 15)
Query Neighborhood Hits	205	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

LBC_HUMAN
NC score	0.524900 (rank : 50)	θ value	4.1701e-05 (rank : 69)
Query Neighborhood Hits	205	Target Neighborhood Hits	90	Shared Neighborhood Hits	56
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

VAV3_MOUSE
NC score	0.522572 (rank : 51)	θ value	8.38298e-14 (rank : 23)
Query Neighborhood Hits	205	Target Neighborhood Hits	404	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.521921 (rank : 52)	θ value	1.68911e-14 (rank : 20)
Query Neighborhood Hits	205	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHGF_HUMAN
NC score	0.517715 (rank : 53)	θ value	0.000786445 (rank : 74)
Query Neighborhood Hits	205	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHG2_HUMAN
NC score	0.514879 (rank : 54)	θ value	1.29631e-06 (rank : 62)
Query Neighborhood Hits	205	Target Neighborhood Hits	142	Shared Neighborhood Hits	61
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

RGNEF_MOUSE
NC score	0.477920 (rank : 55)	θ value	1.99992e-07 (rank : 56)
Query Neighborhood Hits	205	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FGD6_MOUSE
NC score	0.475900 (rank : 56)	θ value	3.19293e-05 (rank : 68)
Query Neighborhood Hits	205	Target Neighborhood Hits	282	Shared Neighborhood Hits	82
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ITSN2_HUMAN
NC score	0.467838 (rank : 57)	θ value	1.47631e-18 (rank : 8)
Query Neighborhood Hits	205	Target Neighborhood Hits	1173	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

FGD6_HUMAN
NC score	0.467731 (rank : 58)	θ value	7.1131e-05 (rank : 71)
Query Neighborhood Hits	205	Target Neighborhood Hits	237	Shared Neighborhood Hits	80
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GNRP_MOUSE
NC score	0.465845 (rank : 59)	θ value	4.0297e-08 (rank : 49)
Query Neighborhood Hits	205	Target Neighborhood Hits	191	Shared Neighborhood Hits	73
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ITSN2_MOUSE
NC score	0.441303 (rank : 60)	θ value	7.32683e-18 (rank : 10)
Query Neighborhood Hits	205	Target Neighborhood Hits	1371	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_MOUSE
NC score	0.427820 (rank : 61)	θ value	2.35696e-16 (rank : 12)
Query Neighborhood Hits	205	Target Neighborhood Hits	1669	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN1_HUMAN
NC score	0.427545 (rank : 62)	θ value	1.80466e-16 (rank : 11)
Query Neighborhood Hits	205	Target Neighborhood Hits	1757	Shared Neighborhood Hits	96
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

GNRP_HUMAN
NC score	0.424403 (rank : 63)	θ value	1.53129e-07 (rank : 54)
Query Neighborhood Hits	205	Target Neighborhood Hits	239	Shared Neighborhood Hits	75
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

FARP2_MOUSE
NC score	0.424331 (rank : 64)	θ value	3.08544e-08 (rank : 46)
Query Neighborhood Hits	205	Target Neighborhood Hits	209	Shared Neighborhood Hits	79
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
NC score	0.403588 (rank : 65)	θ value	1.47974e-10 (rank : 37)
Query Neighborhood Hits	205	Target Neighborhood Hits	240	Shared Neighborhood Hits	77
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ABR_HUMAN
NC score	0.365810 (rank : 66)	θ value	1.99992e-07 (rank : 55)
Query Neighborhood Hits	205	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

FARP1_HUMAN
NC score	0.358548 (rank : 67)	θ value	0.00020696 (rank : 73)
Query Neighborhood Hits	205	Target Neighborhood Hits	241	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

BCR_HUMAN
NC score	0.323962 (rank : 68)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	67
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

FGD5_HUMAN
NC score	0.312283 (rank : 69)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.292570 (rank : 70)	θ value	8.99809 (rank : 192)
Query Neighborhood Hits	205	Target Neighborhood Hits	170	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

SOS1_HUMAN
NC score	0.236721 (rank : 71)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	205	Target Neighborhood Hits	274	Shared Neighborhood Hits	43
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

TRIO_HUMAN
NC score	0.229642 (rank : 72)	θ value	2.35696e-16 (rank : 13)
Query Neighborhood Hits	205	Target Neighborhood Hits	1580	Shared Neighborhood Hits	91
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

SOS2_HUMAN
NC score	0.228758 (rank : 73)	θ value	0.62314 (rank : 109)
Query Neighborhood Hits	205	Target Neighborhood Hits	193	Shared Neighborhood Hits	52
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
NC score	0.227009 (rank : 74)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	205	Target Neighborhood Hits	281	Shared Neighborhood Hits	45
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

DUET_HUMAN
NC score	0.222637 (rank : 75)	θ value	7.84624e-12 (rank : 32)
Query Neighborhood Hits	205	Target Neighborhood Hits	1220	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NCF1_HUMAN
NC score	0.188173 (rank : 76)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SH3K1_HUMAN
NC score	0.186901 (rank : 77)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	205	Target Neighborhood Hits	341	Shared Neighborhood Hits	32
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CD2AP_HUMAN
NC score	0.176608 (rank : 78)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	205	Target Neighborhood Hits	315	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
NC score	0.175812 (rank : 79)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	205	Target Neighborhood Hits	336	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SH3K1_MOUSE
NC score	0.175063 (rank : 80)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	205	Target Neighborhood Hits	332	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF1_MOUSE
NC score	0.174190 (rank : 81)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	28
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SRBS1_MOUSE
NC score	0.159252 (rank : 82)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	205	Target Neighborhood Hits	409	Shared Neighborhood Hits	33
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.158503 (rank : 83)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	205	Target Neighborhood Hits	396	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.158074 (rank : 84)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	205	Target Neighborhood Hits	229	Shared Neighborhood Hits	27
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_MOUSE
NC score	0.153160 (rank : 85)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	205	Target Neighborhood Hits	286	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.152225 (rank : 86)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	205	Target Neighborhood Hits	270	Shared Neighborhood Hits	30
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NCK1_HUMAN
NC score	0.150098 (rank : 87)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	32
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SHAN2_MOUSE
NC score	0.149242 (rank : 88)	θ value	1.38821 (rank : 120)
Query Neighborhood Hits	205	Target Neighborhood Hits	446	Shared Neighborhood Hits	61
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

NCF4_HUMAN
NC score	0.147459 (rank : 89)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	205	Target Neighborhood Hits	161	Shared Neighborhood Hits	20
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.146496 (rank : 90)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	205	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRAP_HUMAN
NC score	0.146312 (rank : 91)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	27
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.145122 (rank : 92)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	205	Target Neighborhood Hits	309	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.144502 (rank : 93)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	205	Target Neighborhood Hits	310	Shared Neighborhood Hits	31
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAC_HUMAN
NC score	0.141386 (rank : 94)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	205	Target Neighborhood Hits	276	Shared Neighborhood Hits	27
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PSD3_HUMAN
NC score	0.141198 (rank : 95)	θ value	1.43324e-05 (rank : 65)
Query Neighborhood Hits	205	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYI0, Q9Y2F1	Gene names	PSD3, EFA6R, HCA67, KIAA0942
Domain Architecture
Description	PH and SEC7 domain-containing protein 3 (Pleckstrin homology and SEC7 domain-containing protein 3) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Hepatocellular carcinoma- associated antigen 67).

PSD4_MOUSE
NC score	0.139562 (rank : 96)	θ value	1.43324e-05 (rank : 66)
Query Neighborhood Hits	205	Target Neighborhood Hits	78	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

STAC_MOUSE
NC score	0.137003 (rank : 97)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	205	Target Neighborhood Hits	268	Shared Neighborhood Hits	27
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB2_HUMAN
NC score	0.134005 (rank : 98)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	205	Target Neighborhood Hits	310	Shared Neighborhood Hits	27
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.133997 (rank : 99)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	27
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC3_MOUSE
NC score	0.128553 (rank : 100)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	205	Target Neighborhood Hits	232	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.127491 (rank : 101)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	205	Target Neighborhood Hits	228	Shared Neighborhood Hits	23
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
NC score	0.126752 (rank : 102)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	205	Target Neighborhood Hits	271	Shared Neighborhood Hits	26
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.125511 (rank : 103)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	205	Target Neighborhood Hits	273	Shared Neighborhood Hits	25
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

HCLS1_MOUSE
NC score	0.124446 (rank : 104)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	205	Target Neighborhood Hits	329	Shared Neighborhood Hits	28
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
NC score	0.123635 (rank : 105)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	205	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PKHF2_HUMAN
NC score	0.123099 (rank : 106)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	205	Target Neighborhood Hits	75	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ABI2_HUMAN
NC score	0.123019 (rank : 107)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	205	Target Neighborhood Hits	350	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GRAP2_HUMAN
NC score	0.122615 (rank : 108)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	205	Target Neighborhood Hits	304	Shared Neighborhood Hits	24
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.122499 (rank : 109)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	22
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PKHF2_MOUSE
NC score	0.122480 (rank : 110)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	205	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ABI2_MOUSE
NC score	0.122249 (rank : 111)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

HCLS1_HUMAN
NC score	0.122006 (rank : 112)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	205	Target Neighborhood Hits	358	Shared Neighborhood Hits	30
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRC8_MOUSE
NC score	0.121571 (rank : 113)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	205	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CRKL_HUMAN
NC score	0.120327 (rank : 114)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	205	Target Neighborhood Hits	313	Shared Neighborhood Hits	26
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

STAM2_MOUSE
NC score	0.120036 (rank : 115)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	205	Target Neighborhood Hits	285	Shared Neighborhood Hits	27
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

PSD4_HUMAN
NC score	0.118891 (rank : 116)	θ value	0.00390308 (rank : 77)
Query Neighborhood Hits	205	Target Neighborhood Hits	178	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

STAM2_HUMAN
NC score	0.118681 (rank : 117)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	205	Target Neighborhood Hits	288	Shared Neighborhood Hits	28
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CRKL_MOUSE
NC score	0.117682 (rank : 118)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	26
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3G3_MOUSE
NC score	0.117550 (rank : 119)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	205	Target Neighborhood Hits	236	Shared Neighborhood Hits	25
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ABI1_MOUSE
NC score	0.116489 (rank : 120)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	26
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PKHF1_HUMAN
NC score	0.115162 (rank : 121)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	205	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

SH3G3_HUMAN
NC score	0.114666 (rank : 122)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	205	Target Neighborhood Hits	222	Shared Neighborhood Hits	25
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

PPIP1_HUMAN
NC score	0.114636 (rank : 123)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	32
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3G1_HUMAN
NC score	0.114282 (rank : 124)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PKHF1_MOUSE
NC score	0.113303 (rank : 125)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	205	Target Neighborhood Hits	80	Shared Neighborhood Hits	17
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

CRK_MOUSE
NC score	0.112466 (rank : 126)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	205	Target Neighborhood Hits	314	Shared Neighborhood Hits	27
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

PPIP1_MOUSE
NC score	0.110913 (rank : 127)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	205	Target Neighborhood Hits	377	Shared Neighborhood Hits	31
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SH3G1_MOUSE
NC score	0.110751 (rank : 128)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	205	Target Neighborhood Hits	291	Shared Neighborhood Hits	28
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
NC score	0.109832 (rank : 129)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	205	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CRK_HUMAN
NC score	0.109742 (rank : 130)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	205	Target Neighborhood Hits	308	Shared Neighborhood Hits	26
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_HUMAN
NC score	0.109447 (rank : 131)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	205	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

BI2L1_HUMAN
NC score	0.109432 (rank : 132)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	205	Target Neighborhood Hits	156	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

SHAN1_HUMAN
NC score	0.109024 (rank : 133)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	205	Target Neighborhood Hits	1041	Shared Neighborhood Hits	79
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PLCG1_MOUSE
NC score	0.108395 (rank : 134)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	205	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G2_MOUSE
NC score	0.108075 (rank : 135)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	205	Target Neighborhood Hits	319	Shared Neighborhood Hits	26
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PLCG1_HUMAN
NC score	0.107309 (rank : 136)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	26
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PDZD7_HUMAN
NC score	0.106896 (rank : 137)	θ value	0.0431538 (rank : 87)
Query Neighborhood Hits	205	Target Neighborhood Hits	181	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SPTA2_HUMAN
NC score	0.105980 (rank : 138)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	205	Target Neighborhood Hits	888	Shared Neighborhood Hits	43
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

WHRN_HUMAN
NC score	0.105322 (rank : 139)	θ value	0.00665767 (rank : 79)
Query Neighborhood Hits	205	Target Neighborhood Hits	325	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

SPTA1_MOUSE
NC score	0.104898 (rank : 140)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	205	Target Neighborhood Hits	675	Shared Neighborhood Hits	38
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

OSTF1_HUMAN
NC score	0.103669 (rank : 141)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	205	Target Neighborhood Hits	466	Shared Neighborhood Hits	28
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

AHI1_HUMAN
NC score	0.102866 (rank : 142)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	205	Target Neighborhood Hits	537	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

OSTF1_MOUSE
NC score	0.102784 (rank : 143)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	205	Target Neighborhood Hits	467	Shared Neighborhood Hits	27
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OBSCN_HUMAN
NC score	0.102782 (rank : 144)	θ value	3.77169e-06 (rank : 64)
Query Neighborhood Hits	205	Target Neighborhood Hits	1931	Shared Neighborhood Hits	71
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

WHRN_MOUSE
NC score	0.102663 (rank : 145)	θ value	0.0252991 (rank : 84)
Query Neighborhood Hits	205	Target Neighborhood Hits	412	Shared Neighborhood Hits	52
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

ABI3_HUMAN
NC score	0.102031 (rank : 146)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

DBNL_HUMAN
NC score	0.100130 (rank : 147)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	205	Target Neighborhood Hits	244	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

AHI1_MOUSE
NC score	0.099517 (rank : 148)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	205	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ABI3_MOUSE
NC score	0.098496 (rank : 149)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	205	Target Neighborhood Hits	227	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PDZD3_HUMAN
NC score	0.098451 (rank : 150)	θ value	0.0431538 (rank : 86)
Query Neighborhood Hits	205	Target Neighborhood Hits	180	Shared Neighborhood Hits	44
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SPTA1_HUMAN
NC score	0.097940 (rank : 151)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	205	Target Neighborhood Hits	748	Shared Neighborhood Hits	41
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TCGAP_MOUSE
NC score	0.097776 (rank : 152)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	205	Target Neighborhood Hits	409	Shared Neighborhood Hits	37
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

DBNL_MOUSE
NC score	0.097018 (rank : 153)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	205	Target Neighborhood Hits	306	Shared Neighborhood Hits	27
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PLCG2_HUMAN
NC score	0.095349 (rank : 154)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	205	Target Neighborhood Hits	280	Shared Neighborhood Hits	21
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NPHP1_MOUSE
NC score	0.093873 (rank : 155)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	205	Target Neighborhood Hits	267	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

CNKR1_HUMAN
NC score	0.092954 (rank : 156)	θ value	0.21417 (rank : 93)
Query Neighborhood Hits	205	Target Neighborhood Hits	154	Shared Neighborhood Hits	32
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

RHG04_HUMAN
NC score	0.092894 (rank : 157)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	29
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

NOXO1_MOUSE
NC score	0.092196 (rank : 158)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	205	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PEX13_MOUSE
NC score	0.091893 (rank : 159)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	205	Target Neighborhood Hits	126	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ANM2_HUMAN
NC score	0.090017 (rank : 160)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	205	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

PEX13_HUMAN
NC score	0.089073 (rank : 161)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	205	Target Neighborhood Hits	128	Shared Neighborhood Hits	19
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

LASP1_HUMAN
NC score	0.088722 (rank : 162)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

TCGAP_HUMAN
NC score	0.087890 (rank : 163)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	205	Target Neighborhood Hits	872	Shared Neighborhood Hits	40
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RPGF2_HUMAN
NC score	0.086782 (rank : 164)	θ value	0.47712 (rank : 100)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

NHRF2_HUMAN
NC score	0.086597 (rank : 165)	θ value	1.06291 (rank : 117)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	45
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PACN2_MOUSE
NC score	0.086421 (rank : 166)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	205	Target Neighborhood Hits	382	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

LASP1_MOUSE
NC score	0.086307 (rank : 167)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	26
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BI2L1_MOUSE
NC score	0.085990 (rank : 168)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CT032_HUMAN
NC score	0.085754 (rank : 169)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	205	Target Neighborhood Hits	235	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

PACN2_HUMAN
NC score	0.085492 (rank : 170)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	205	Target Neighborhood Hits	339	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PDZK4_MOUSE
NC score	0.085469 (rank : 171)	θ value	0.00102713 (rank : 75)
Query Neighborhood Hits	205	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

BCAR1_MOUSE
NC score	0.084667 (rank : 172)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	205	Target Neighborhood Hits	438	Shared Neighborhood Hits	29
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

LMO7_HUMAN
NC score	0.084587 (rank : 173)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	205	Target Neighborhood Hits	507	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

NHRF2_MOUSE
NC score	0.084544 (rank : 174)	θ value	0.62314 (rank : 106)
Query Neighborhood Hits	205	Target Neighborhood Hits	194	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

NOXO1_HUMAN
NC score	0.084362 (rank : 175)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	205	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SPTB2_HUMAN
NC score	0.083943 (rank : 176)	θ value	9.29e-05 (rank : 72)
Query Neighborhood Hits	205	Target Neighborhood Hits	748	Shared Neighborhood Hits	44
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ANM2_MOUSE
NC score	0.083071 (rank : 177)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	205	Target Neighborhood Hits	175	Shared Neighborhood Hits	20
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SPTB2_MOUSE
NC score	0.082968 (rank : 178)	θ value	5.44631e-05 (rank : 70)
Query Neighborhood Hits	205	Target Neighborhood Hits	770	Shared Neighborhood Hits	42
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

BCAR1_HUMAN
NC score	0.082126 (rank : 179)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	205	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PDZD1_MOUSE
NC score	0.082027 (rank : 180)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	205	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PACN3_MOUSE
NC score	0.081761 (rank : 181)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	205	Target Neighborhood Hits	380	Shared Neighborhood Hits	28
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

NEBL_HUMAN
NC score	0.081593 (rank : 182)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	205	Target Neighborhood Hits	457	Shared Neighborhood Hits	30
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

RHG12_HUMAN
NC score	0.081361 (rank : 183)	θ value	0.00134147 (rank : 76)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CASL_HUMAN
NC score	0.081288 (rank : 184)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	205	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PACN3_HUMAN
NC score	0.080001 (rank : 185)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	205	Target Neighborhood Hits	385	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PZRN4_HUMAN
NC score	0.079507 (rank : 186)	θ value	0.0961366 (rank : 89)
Query Neighborhood Hits	205	Target Neighborhood Hits	438	Shared Neighborhood Hits	49
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RPGF6_HUMAN
NC score	0.079484 (rank : 187)	θ value	6.88961 (rank : 182)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PDZD1_HUMAN
NC score	0.079394 (rank : 188)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

RIMB2_HUMAN
NC score	0.079326 (rank : 189)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	205	Target Neighborhood Hits	263	Shared Neighborhood Hits	23
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PACN1_HUMAN
NC score	0.079084 (rank : 190)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	205	Target Neighborhood Hits	320	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SPTN2_HUMAN
NC score	0.078745 (rank : 191)	θ value	0.00509761 (rank : 78)
Query Neighborhood Hits	205	Target Neighborhood Hits	535	Shared Neighborhood Hits	37
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

RIMB2_MOUSE
NC score	0.077834 (rank : 192)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	19
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

PACN1_MOUSE
NC score	0.077621 (rank : 193)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	205	Target Neighborhood Hits	283	Shared Neighborhood Hits	27
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

CASL_MOUSE
NC score	0.077222 (rank : 194)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	205	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

NPHP1_HUMAN
NC score	0.077129 (rank : 195)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	205	Target Neighborhood Hits	288	Shared Neighborhood Hits	29
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

STAP1_MOUSE
NC score	0.076835 (rank : 196)	θ value	0.0736092 (rank : 88)
Query Neighborhood Hits	205	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

PDZD3_MOUSE
NC score	0.076206 (rank : 197)	θ value	5.27518 (rank : 168)
Query Neighborhood Hits	205	Target Neighborhood Hits	171	Shared Neighborhood Hits	44
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

ZO3_HUMAN
NC score	0.075497 (rank : 198)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	205	Target Neighborhood Hits	219	Shared Neighborhood Hits	43
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SRGP1_HUMAN
NC score	0.075396 (rank : 199)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	205	Target Neighborhood Hits	390	Shared Neighborhood Hits	32
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_MOUSE
NC score	0.074996 (rank : 200)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	205	Target Neighborhood Hits	324	Shared Neighborhood Hits	30
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.074269 (rank : 201)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	205	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

FNBP2_HUMAN
NC score	0.073528 (rank : 202)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	205	Target Neighborhood Hits	432	Shared Neighborhood Hits	34
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRP3_HUMAN
NC score	0.073282 (rank : 203)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

EFS_MOUSE
NC score	0.073256 (rank : 204)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	30
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

RHG26_HUMAN
NC score	0.073164 (rank : 205)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	205	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RHG12_MOUSE
NC score	0.072729 (rank : 206)	θ value	0.0148317 (rank : 80)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

NEBU_HUMAN
NC score	0.072598 (rank : 207)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	205	Target Neighborhood Hits	420	Shared Neighborhood Hits	28
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CNKR2_MOUSE
NC score	0.072077 (rank : 208)	θ value	0.62314 (rank : 103)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA6_HUMAN
NC score	0.071578 (rank : 209)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	205	Target Neighborhood Hits	556	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CNKR2_HUMAN
NC score	0.071526 (rank : 210)	θ value	0.62314 (rank : 102)
Query Neighborhood Hits	205	Target Neighborhood Hits	197	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

MAGI1_HUMAN
NC score	0.071462 (rank : 211)	θ value	0.21417 (rank : 94)
Query Neighborhood Hits	205	Target Neighborhood Hits	388	Shared Neighborhood Hits	56
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

ZFY28_HUMAN
NC score	0.071221 (rank : 212)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

EFS_HUMAN
NC score	0.071004 (rank : 213)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	205	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

RGL1_HUMAN
NC score	0.070984 (rank : 214)	θ value	0.163984 (rank : 92)
Query Neighborhood Hits	205	Target Neighborhood Hits	43	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

PKHA2_MOUSE
NC score	0.070948 (rank : 215)	θ value	0.62314 (rank : 108)
Query Neighborhood Hits	205	Target Neighborhood Hits	116	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA6_MOUSE
NC score	0.070726 (rank : 216)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	205	Target Neighborhood Hits	591	Shared Neighborhood Hits	47
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

USH1C_HUMAN
NC score	0.070700 (rank : 217)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	205	Target Neighborhood Hits	327	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

ZO3_MOUSE
NC score	0.069909 (rank : 218)	θ value	0.365318 (rank : 97)
Query Neighborhood Hits	205	Target Neighborhood Hits	224	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ZFYV9_HUMAN
NC score	0.069312 (rank : 219)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	205	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

DDEF2_HUMAN
NC score	0.068319 (rank : 220)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	205	Target Neighborhood Hits	599	Shared Neighborhood Hits	37
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

USH1C_MOUSE
NC score	0.068004 (rank : 221)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	205	Target Neighborhood Hits	557	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

SHAN2_HUMAN
NC score	0.067502 (rank : 222)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	205	Target Neighborhood Hits	346	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

NHERF_HUMAN
NC score	0.067476 (rank : 223)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	205	Target Neighborhood Hits	190	Shared Neighborhood Hits	42
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

IASPP_MOUSE
NC score	0.066971 (rank : 224)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	205	Target Neighborhood Hits	1024	Shared Neighborhood Hits	32
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

REPS2_MOUSE
NC score	0.066674 (rank : 225)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	205	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

DDEF2_MOUSE
NC score	0.066397 (rank : 226)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	205	Target Neighborhood Hits	625	Shared Neighborhood Hits	35
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

BAIP2_MOUSE
NC score	0.066226 (rank : 227)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	205	Target Neighborhood Hits	185	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

MAGI1_MOUSE
NC score	0.065999 (rank : 228)	θ value	0.62314 (rank : 105)
Query Neighborhood Hits	205	Target Neighborhood Hits	403	Shared Neighborhood Hits	54
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

RGL1_MOUSE
NC score	0.065864 (rank : 229)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	205	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

ZFY16_MOUSE
NC score	0.065782 (rank : 230)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	205	Target Neighborhood Hits	108	Shared Neighborhood Hits	14
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

IASPP_HUMAN
NC score	0.065574 (rank : 231)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	205	Target Neighborhood Hits	688	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

REPS2_HUMAN
NC score	0.065309 (rank : 232)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RBNS5_HUMAN
NC score	0.064873 (rank : 233)	θ value	5.27518 (rank : 169)
Query Neighborhood Hits	205	Target Neighborhood Hits	242	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

BAIP2_HUMAN
NC score	0.064487 (rank : 234)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	205	Target Neighborhood Hits	192	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

ZFY21_MOUSE
NC score	0.064402 (rank : 235)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	205	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

PKHA5_HUMAN
NC score	0.064129 (rank : 236)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	205	Target Neighborhood Hits	455	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

ASPP1_MOUSE
NC score	0.064034 (rank : 237)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	205	Target Neighborhood Hits	1244	Shared Neighborhood Hits	45
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ZFY16_HUMAN
NC score	0.063631 (rank : 238)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	205	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

NHERF_MOUSE
NC score	0.063383 (rank : 239)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	205	Target Neighborhood Hits	195	Shared Neighborhood Hits	43
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PKHA2_HUMAN
NC score	0.063176 (rank : 240)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	205	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SNX18_MOUSE
NC score	0.062782 (rank : 241)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ZFY21_HUMAN
NC score	0.062447 (rank : 242)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	205	Target Neighborhood Hits	72	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

P85A_HUMAN
NC score	0.062434 (rank : 243)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	205	Target Neighborhood Hits	479	Shared Neighborhood Hits	27
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ZO1_MOUSE
NC score	0.062122 (rank : 244)	θ value	0.813845 (rank : 114)
Query Neighborhood Hits	205	Target Neighborhood Hits	453	Shared Neighborhood Hits	45
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

STAP1_HUMAN
NC score	0.062032 (rank : 245)	θ value	0.365318 (rank : 95)
Query Neighborhood Hits	205	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

DDEF1_MOUSE
NC score	0.061984 (rank : 246)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	205	Target Neighborhood Hits	592	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ASPP1_HUMAN
NC score	0.061748 (rank : 247)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	205	Target Neighborhood Hits	956	Shared Neighborhood Hits	35
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

P85A_MOUSE
NC score	0.061304 (rank : 248)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	205	Target Neighborhood Hits	435	Shared Neighborhood Hits	24
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ZO1_HUMAN
NC score	0.061219 (rank : 249)	θ value	0.813845 (rank : 113)
Query Neighborhood Hits	205	Target Neighborhood Hits	474	Shared Neighborhood Hits	48
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNX18_HUMAN
NC score	0.060602 (rank : 250)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	205	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

RHG25_MOUSE
NC score	0.059585 (rank : 251)	θ value	0.47712 (rank : 99)
Query Neighborhood Hits	205	Target Neighborhood Hits	492	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

P85B_HUMAN
NC score	0.059302 (rank : 252)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	205	Target Neighborhood Hits	543	Shared Neighborhood Hits	28
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

REPS1_MOUSE
NC score	0.058487 (rank : 253)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	205	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

SPTN4_HUMAN
NC score	0.058436 (rank : 254)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	205	Target Neighborhood Hits	570	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

HGS_MOUSE
NC score	0.058068 (rank : 255)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	205	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

TX1B3_MOUSE
NC score	0.058008 (rank : 256)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	205	Target Neighborhood Hits	158	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

HGS_HUMAN
NC score	0.057932 (rank : 257)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	205	Target Neighborhood Hits	517	Shared Neighborhood Hits	27
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

TX1B3_HUMAN
NC score	0.057908 (rank : 258)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	205	Target Neighborhood Hits	161	Shared Neighborhood Hits	41
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

MIA_MOUSE
NC score	0.057307 (rank : 259)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	205	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q61865, O09086, P97495	Gene names	Mia, Cdrap, Mia1
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity) (Cartilage-derived retinoic acid-sensitive protein) (CD-RAP).

MIA_HUMAN
NC score	0.057157 (rank : 260)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	205	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	Q16674	Gene names	MIA
Domain Architecture
Description	Melanoma-derived growth regulatory protein precursor (Melanoma inhibitory activity).

MYO1F_MOUSE
NC score	0.056751 (rank : 261)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	205	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1E_HUMAN
NC score	0.056228 (rank : 262)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	205	Target Neighborhood Hits	293	Shared Neighborhood Hits	31
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

RBNS5_MOUSE
NC score	0.056100 (rank : 263)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	205	Target Neighborhood Hits	266	Shared Neighborhood Hits	22
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

PARD3_MOUSE
NC score	0.055877 (rank : 264)	θ value	5.27518 (rank : 167)
Query Neighborhood Hits	205	Target Neighborhood Hits	290	Shared Neighborhood Hits	47
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

MYO1F_HUMAN
NC score	0.055809 (rank : 265)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	205	Target Neighborhood Hits	275	Shared Neighborhood Hits	28
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

PARD3_HUMAN
NC score	0.055775 (rank : 266)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	205	Target Neighborhood Hits	312	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

CNN1_HUMAN
NC score	0.055763 (rank : 267)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	205	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	P51911, O00638, Q15416, Q8IY93, Q99438	Gene names	CNN1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

REPS1_HUMAN
NC score	0.055693 (rank : 268)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	205	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96D71, Q8NDR7, Q8WU62, Q9BXY9	Gene names	REPS1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

CNN1_MOUSE
NC score	0.055679 (rank : 269)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	205	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q08091	Gene names	Cnn1
Domain Architecture
Description	Calponin-1 (Calponin H1, smooth muscle) (Basic calponin).

CNN2_MOUSE
NC score	0.054989 (rank : 270)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	205	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	Q08093	Gene names	Cnn2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

PKHA4_MOUSE
NC score	0.054782 (rank : 271)	θ value	8.99809 (rank : 201)
Query Neighborhood Hits	205	Target Neighborhood Hits	202	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

P85B_MOUSE
NC score	0.054711 (rank : 272)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	205	Target Neighborhood Hits	519	Shared Neighborhood Hits	26
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ZO2_HUMAN
NC score	0.054462 (rank : 273)	θ value	8.99809 (rank : 204)
Query Neighborhood Hits	205	Target Neighborhood Hits	289	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MPDZ_HUMAN
NC score	0.053478 (rank : 274)	θ value	8.99809 (rank : 195)
Query Neighborhood Hits	205	Target Neighborhood Hits	261	Shared Neighborhood Hits	50
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

ZO2_MOUSE
NC score	0.053411 (rank : 275)	θ value	8.99809 (rank : 205)
Query Neighborhood Hits	205	Target Neighborhood Hits	296	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

SNX9_HUMAN
NC score	0.053272 (rank : 276)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	205	Target Neighborhood Hits	148	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

INADL_MOUSE
NC score	0.053052 (rank : 277)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	205	Target Neighborhood Hits	290	Shared Neighborhood Hits	50
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

PLEK_HUMAN
NC score	0.053023 (rank : 278)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	205	Target Neighborhood Hits	110	Shared Neighborhood Hits	29
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CNN3_MOUSE
NC score	0.052936 (rank : 279)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	205	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DAW9, Q3TW23	Gene names	Cnn3
Domain Architecture	No domain graphic available
Description	Calponin-3 (Calponin, acidic isoform).

CNN3_HUMAN
NC score	0.052816 (rank : 280)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	205	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q15417	Gene names	CNN3
Domain Architecture
Description	Calponin-3 (Calponin, acidic isoform).

LNX2_MOUSE
NC score	0.052756 (rank : 281)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	205	Target Neighborhood Hits	407	Shared Neighborhood Hits	43
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

RUSC1_MOUSE
NC score	0.052356 (rank : 282)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	205	Target Neighborhood Hits	206	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

PAR6A_HUMAN
NC score	0.051927 (rank : 283)	θ value	1.06291 (rank : 118)
Query Neighborhood Hits	205	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

INADL_HUMAN
NC score	0.051848 (rank : 284)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	205	Target Neighborhood Hits	260	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LNX2_HUMAN
NC score	0.051669 (rank : 285)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	205	Target Neighborhood Hits	389	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

RIMB1_HUMAN
NC score	0.051652 (rank : 286)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	205	Target Neighborhood Hits	1479	Shared Neighborhood Hits	51
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CNN2_HUMAN
NC score	0.051479 (rank : 287)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	205	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q99439, Q92578	Gene names	CNN2
Domain Architecture
Description	Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin).

PAR6A_MOUSE
NC score	0.051445 (rank : 288)	θ value	0.62314 (rank : 107)
Query Neighborhood Hits	205	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

LAP4_HUMAN
NC score	0.051346 (rank : 289)	θ value	0.0193708 (rank : 81)
Query Neighborhood Hits	205	Target Neighborhood Hits	608	Shared Neighborhood Hits	53
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

APBA3_HUMAN
NC score	0.051170 (rank : 290)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	205	Target Neighborhood Hits	201	Shared Neighborhood Hits	45
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PLEK2_MOUSE
NC score	0.051165 (rank : 291)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	205	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

LIN7B_MOUSE
NC score	0.051133 (rank : 292)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

SPTN5_HUMAN
NC score	0.050859 (rank : 293)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	205	Target Neighborhood Hits	674	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

LIN7B_HUMAN
NC score	0.050758 (rank : 294)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MAGI2_MOUSE
NC score	0.050758 (rank : 295)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	205	Target Neighborhood Hits	370	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

DLG2_HUMAN
NC score	0.050626 (rank : 296)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	205	Target Neighborhood Hits	279	Shared Neighborhood Hits	55
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PAR3L_HUMAN
NC score	0.050340 (rank : 297)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	205	Target Neighborhood Hits	297	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

ES8L3_HUMAN
NC score	0.050306 (rank : 298)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	205	Target Neighborhood Hits	206	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

MAGI2_HUMAN
NC score	0.050150 (rank : 299)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	205	Target Neighborhood Hits	373	Shared Neighborhood Hits	51
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

GRIP1_MOUSE
NC score	0.049803 (rank : 300)	θ value	8.99809 (rank : 193)
Query Neighborhood Hits	205	Target Neighborhood Hits	241	Shared Neighborhood Hits	51
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

DLG5_HUMAN
NC score	0.047728 (rank : 301)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	205	Target Neighborhood Hits	1088	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

RHG25_HUMAN
NC score	0.046826 (rank : 302)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	205	Target Neighborhood Hits	550	Shared Neighborhood Hits	39
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

LAP4_MOUSE
NC score	0.046302 (rank : 303)	θ value	0.125558 (rank : 90)
Query Neighborhood Hits	205	Target Neighborhood Hits	590	Shared Neighborhood Hits	52
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PLEK2_HUMAN
NC score	0.046182 (rank : 304)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	205	Target Neighborhood Hits	101	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

TXLNB_HUMAN
NC score	0.045894 (rank : 305)	θ value	0.0252991 (rank : 83)
Query Neighborhood Hits	205	Target Neighborhood Hits	912	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

MDN1_HUMAN
NC score	0.041007 (rank : 306)	θ value	0.0431538 (rank : 85)
Query Neighborhood Hits	205	Target Neighborhood Hits	662	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

DMD_MOUSE
NC score	0.039449 (rank : 307)	θ value	2.36792 (rank : 128)
Query Neighborhood Hits	205	Target Neighborhood Hits	1111	Shared Neighborhood Hits	33
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

FLIP1_HUMAN
NC score	0.037586 (rank : 308)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	205	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

SDCB2_HUMAN
NC score	0.036404 (rank : 309)	θ value	3.0926 (rank : 143)
Query Neighborhood Hits	205	Target Neighborhood Hits	121	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

GOGB1_HUMAN
NC score	0.034749 (rank : 310)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	205	Target Neighborhood Hits	2297	Shared Neighborhood Hits	64
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

TXLNB_MOUSE
NC score	0.033986 (rank : 311)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	205	Target Neighborhood Hits	640	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

ACOT3_MOUSE
NC score	0.032451 (rank : 312)	θ value	0.0252991 (rank : 82)
Query Neighborhood Hits	205	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYR7, Q6Q2Z7	Gene names	Acot3, Pte1a, Pte2, Pte2a
Domain Architecture
Description	Acyl-coenzyme A thioesterase 3 (EC 3.1.2.2) (Acyl-CoA thioesterase 3) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (PTE-Ia).

RFIP3_HUMAN
NC score	0.032245 (rank : 313)	θ value	5.27518 (rank : 170)
Query Neighborhood Hits	205	Target Neighborhood Hits	1055	Shared Neighborhood Hits	35
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

MLL2_HUMAN
NC score	0.030329 (rank : 314)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	205	Target Neighborhood Hits	1788	Shared Neighborhood Hits	44
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

CE290_HUMAN
NC score	0.028749 (rank : 315)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	205	Target Neighborhood Hits	1553	Shared Neighborhood Hits	37
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

REST_MOUSE
NC score	0.026838 (rank : 316)	θ value	6.88961 (rank : 181)
Query Neighborhood Hits	205	Target Neighborhood Hits	1506	Shared Neighborhood Hits	40
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

PININ_HUMAN
NC score	0.025850 (rank : 317)	θ value	8.99809 (rank : 200)
Query Neighborhood Hits	205	Target Neighborhood Hits	753	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

CD016_HUMAN
NC score	0.025106 (rank : 318)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	205	Target Neighborhood Hits	70	Shared Neighborhood Hits	4
SwissProt Accessions	Q63HQ0, Q96GG6, Q9H0V0, Q9P1L4	Gene names	C4orf16
Domain Architecture	No domain graphic available
Description	Protein C4orf16.

MYO10_HUMAN
NC score	0.024602 (rank : 319)	θ value	1.06291 (rank : 116)
Query Neighborhood Hits	205	Target Neighborhood Hits	920	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

RIMS2_MOUSE
NC score	0.024581 (rank : 320)	θ value	5.27518 (rank : 172)
Query Neighborhood Hits	205	Target Neighborhood Hits	376	Shared Neighborhood Hits	32
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RIMS2_HUMAN
NC score	0.024374 (rank : 321)	θ value	5.27518 (rank : 171)
Query Neighborhood Hits	205	Target Neighborhood Hits	342	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

ACOT2_HUMAN
NC score	0.024254 (rank : 322)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	205	Target Neighborhood Hits	15	Shared Neighborhood Hits	6
SwissProt Accessions	P49753, Q9NUX4	Gene names	ACOT2, PTE2, PTE2A
Domain Architecture
Description	Acyl-coenzyme A thioesterase 2 (EC 3.1.2.2) (Acyl-CoA thioesterase 2) (Peroxisomal acyl-coenzyme A thioester hydrolase 2a) (Peroxisomal long-chain acyl-coA thioesterase 2) (ZAP128) (CTE-Ia).

ACOT1_HUMAN
NC score	0.023699 (rank : 323)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	205	Target Neighborhood Hits	16	Shared Neighborhood Hits	6
SwissProt Accessions	Q86TX2, Q3I5F9	Gene names	ACOT1, CTE1
Domain Architecture	No domain graphic available
Description	Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (Acyl-CoA thioesterase 1) (Inducible cytosolic acyl-coenzyme A thioester hydrolase) (Long chain acyl-CoA thioester hydrolase) (Long chain acyl-CoA hydrolase) (CTE-I) (CTE-Ib).

SYN2_MOUSE
NC score	0.023254 (rank : 324)	θ value	0.813845 (rank : 112)
Query Neighborhood Hits	205	Target Neighborhood Hits	183	Shared Neighborhood Hits	4
SwissProt Accessions	Q64332, Q6NZR0, Q9QWV7	Gene names	Syn2
Domain Architecture	No domain graphic available
Description	Synapsin-2 (Synapsin II).

TEX2_HUMAN
NC score	0.022576 (rank : 325)	θ value	6.88961 (rank : 183)
Query Neighborhood Hits	205	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

AP3B1_MOUSE
NC score	0.022312 (rank : 326)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	205	Target Neighborhood Hits	302	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

SAMD9_HUMAN
NC score	0.022283 (rank : 327)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	205	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q5K651, Q6P080, Q75N21, Q8IVG6, Q9NXS8	Gene names	SAMD9, KIAA2004, OEF1
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 9.

PMS2_HUMAN
NC score	0.021499 (rank : 328)	θ value	0.813845 (rank : 111)
Query Neighborhood Hits	205	Target Neighborhood Hits	131	Shared Neighborhood Hits	7
SwissProt Accessions	P54278	Gene names	PMS2, PMSL2
Domain Architecture
Description	PMS1 protein homolog 2 (DNA mismatch repair protein PMS2).

CCD38_MOUSE
NC score	0.020780 (rank : 329)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	205	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CDN8, Q8CDD6, Q8CDE1	Gene names	Ccdc38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

MUC13_MOUSE
NC score	0.020243 (rank : 330)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	205	Target Neighborhood Hits	447	Shared Neighborhood Hits	8
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

CSPG5_HUMAN
NC score	0.019230 (rank : 331)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	205	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

A4_MOUSE
NC score	0.018802 (rank : 332)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	205	Target Neighborhood Hits	275	Shared Neighborhood Hits	14
SwissProt Accessions	P12023, P97487, P97942, Q99K32	Gene names	App
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimer disease amyloid protein homolog) (Amyloidogenic glycoprotein) (AG) [Contains: Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99); Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); Gamma-CTF(59) (Gamma-secretase C-terminal fragment 59) (Amyloid intracellular domain 59) (AID(59)) (APP-C59); Gamma-CTF(57) (Gamma-secretase C-terminal fragment 57) (Amyloid intracellular domain 57) (AID(57)) (APP-C57); Gamma-CTF(50) (Gamma-secretase C-terminal fragment 50) (Amyloid intracellular domain 50) (AID(50)); C31].

UBP10_MOUSE
NC score	0.018540 (rank : 333)	θ value	0.47712 (rank : 101)
Query Neighborhood Hits	205	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

MYH9_HUMAN
NC score	0.018353 (rank : 334)	θ value	8.99809 (rank : 196)
Query Neighborhood Hits	205	Target Neighborhood Hits	1762	Shared Neighborhood Hits	45
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

ENPL_HUMAN
NC score	0.017264 (rank : 335)	θ value	0.62314 (rank : 104)
Query Neighborhood Hits	205	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

DYN3_HUMAN
NC score	0.016641 (rank : 336)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	205	Target Neighborhood Hits	158	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

DYN2_HUMAN
NC score	0.016512 (rank : 337)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	205	Target Neighborhood Hits	112	Shared Neighborhood Hits	16
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.016421 (rank : 338)	θ value	8.99809 (rank : 191)
Query Neighborhood Hits	205	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

AFF1_MOUSE
NC score	0.016058 (rank : 339)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	205	Target Neighborhood Hits	351	Shared Neighborhood Hits	15
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

LCP2_HUMAN
NC score	0.015689 (rank : 340)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	205	Target Neighborhood Hits	531	Shared Neighborhood Hits	18
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MIER1_MOUSE
NC score	0.014910 (rank : 341)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	205	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q5UAK0, Q5UAK1, Q5UAK2, Q5UAK3, Q6ZPL6, Q9D402	Gene names	Mier1, Kiaa1610
Domain Architecture	No domain graphic available
Description	Mesoderm induction early response protein 1 (Mi-er1).

THAP4_HUMAN
NC score	0.013912 (rank : 342)	θ value	3.0926 (rank : 144)
Query Neighborhood Hits	205	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WY91, Q53NU7, Q6GRN0, Q6IPJ3, Q9NW26, Q9Y325	Gene names	THAP4
Domain Architecture
Description	THAP domain-containing protein 4.

K1543_MOUSE
NC score	0.013708 (rank : 343)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	205	Target Neighborhood Hits	497	Shared Neighborhood Hits	20
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

AKA12_HUMAN
NC score	0.012527 (rank : 344)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	205	Target Neighborhood Hits	825	Shared Neighborhood Hits	18
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

OS9_HUMAN
NC score	0.010995 (rank : 345)	θ value	8.99809 (rank : 198)
Query Neighborhood Hits	205	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

PPR3A_HUMAN
NC score	0.009742 (rank : 346)	θ value	6.88961 (rank : 180)
Query Neighborhood Hits	205	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q16821, O43476, Q75LN8, Q7KYM8, Q86UI6	Gene names	PPP1R3A, PP1G
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit).

NUP62_MOUSE
NC score	0.009700 (rank : 347)	θ value	8.99809 (rank : 197)
Query Neighborhood Hits	205	Target Neighborhood Hits	200	Shared Neighborhood Hits	9
SwissProt Accessions	Q63850, Q99JN7	Gene names	Nup62
Domain Architecture
Description	Nuclear pore glycoprotein p62 (62 kDa nucleoporin).

CAMKV_HUMAN
NC score	0.009405 (rank : 348)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	205	Target Neighborhood Hits	1084	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

KAP1_HUMAN
NC score	0.009288 (rank : 349)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	205	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

AP3B2_MOUSE
NC score	0.008639 (rank : 350)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	205	Target Neighborhood Hits	246	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

NPAS3_HUMAN
NC score	0.008526 (rank : 351)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	205	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

FA76A_MOUSE
NC score	0.008318 (rank : 352)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	205	Target Neighborhood Hits	152	Shared Neighborhood Hits	6
SwissProt Accessions	Q922G2, Q3U3U8, Q3V3N2	Gene names	Fam76a
Domain Architecture	No domain graphic available
Description	Protein FAM76A.

NPAS3_MOUSE
NC score	0.008093 (rank : 353)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	205	Target Neighborhood Hits	103	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

LIMK2_MOUSE
NC score	0.008027 (rank : 354)	θ value	0.163984 (rank : 91)
Query Neighborhood Hits	205	Target Neighborhood Hits	998	Shared Neighborhood Hits	31
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TRPS1_MOUSE
NC score	0.006915 (rank : 355)	θ value	3.0926 (rank : 145)
Query Neighborhood Hits	205	Target Neighborhood Hits	609	Shared Neighborhood Hits	6
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

TNR8_HUMAN
NC score	0.006878 (rank : 356)	θ value	6.88961 (rank : 184)
Query Neighborhood Hits	205	Target Neighborhood Hits	198	Shared Neighborhood Hits	2
SwissProt Accessions	P28908	Gene names	TNFRSF8, CD30
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Lymphocyte activation antigen CD30) (KI-1 antigen).

2DOB_HUMAN
NC score	0.006810 (rank : 357)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	205	Target Neighborhood Hits	201	Shared Neighborhood Hits	3
SwissProt Accessions	P13765, Q29746, Q29825	Gene names	HLA-DOB
Domain Architecture
Description	HLA class II histocompatibility antigen, DO beta chain precursor (MHC class II antigen DOB).

HDAC7_MOUSE
NC score	0.006463 (rank : 358)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	205	Target Neighborhood Hits	85	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

LIMK2_HUMAN
NC score	0.005299 (rank : 359)	θ value	8.99809 (rank : 194)
Query Neighborhood Hits	205	Target Neighborhood Hits	986	Shared Neighborhood Hits	31
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK5_HUMAN
NC score	0.004959 (rank : 360)	θ value	8.99809 (rank : 202)
Query Neighborhood Hits	205	Target Neighborhood Hits	864	Shared Neighborhood Hits	13
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LIMK1_HUMAN
NC score	0.004895 (rank : 361)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	205	Target Neighborhood Hits	1005	Shared Neighborhood Hits	29
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

SCN2A_HUMAN
NC score	0.004696 (rank : 362)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	205	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

CO8B_HUMAN
NC score	0.004642 (rank : 363)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	205	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

RIPK5_MOUSE
NC score	0.004572 (rank : 364)	θ value	8.99809 (rank : 203)
Query Neighborhood Hits	205	Target Neighborhood Hits	874	Shared Neighborhood Hits	12
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

CBLB_HUMAN
NC score	0.003829 (rank : 365)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	205	Target Neighborhood Hits	261	Shared Neighborhood Hits	4
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

PO2F1_MOUSE
NC score	0.003455 (rank : 366)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	205	Target Neighborhood Hits	408	Shared Neighborhood Hits	8
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

PDE4B_HUMAN
NC score	0.003329 (rank : 367)	θ value	8.99809 (rank : 199)
Query Neighborhood Hits	205	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

FBXW7_HUMAN
NC score	0.003012 (rank : 368)	θ value	1.06291 (rank : 115)
Query Neighborhood Hits	205	Target Neighborhood Hits	433	Shared Neighborhood Hits	7
SwissProt Accessions	Q969H0, Q96A16, Q96LE0, Q96RI2, Q9NUX6	Gene names	FBXW7, FBW7, FBX30, SEL10
Domain Architecture
Description	F-box/WD repeat protein 7 (F-box and WD-40 domain protein 7) (F-box protein FBX30) (hCdc4) (Archipelago homolog) (hAgo) (SEL-10).

LPHN2_HUMAN
NC score	0.001457 (rank : 369)	θ value	6.88961 (rank : 178)
Query Neighborhood Hits	205	Target Neighborhood Hits	136	Shared Neighborhood Hits	5
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

ABCA9_HUMAN
NC score	0.001203 (rank : 370)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	205	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

KRHB6_MOUSE
NC score	0.000937 (rank : 371)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	205	Target Neighborhood Hits	413	Shared Neighborhood Hits	12
SwissProt Accessions	P97861, Q3TTV9	Gene names	Krthb6, Krt2-10
Domain Architecture	No domain graphic available
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6).

PP16B_HUMAN
NC score	-0.000155 (rank : 372)	θ value	6.88961 (rank : 179)
Query Neighborhood Hits	205	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ATBF1_HUMAN
NC score	-0.000321 (rank : 373)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	205	Target Neighborhood Hits	1547	Shared Neighborhood Hits	21
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ADA2A_HUMAN
NC score	-0.002910 (rank : 374)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	205	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

ADA2A_MOUSE
NC score	-0.003651 (rank : 375)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	205	Target Neighborhood Hits	900	Shared Neighborhood Hits	4
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

ZN206_HUMAN
NC score	-0.004926 (rank : 376)	θ value	0.62314 (rank : 110)
Query Neighborhood Hits	205	Target Neighborhood Hits	853	Shared Neighborhood Hits	8
SwissProt Accessions	Q96SZ4	Gene names	ZNF206, ZSCAN10
Domain Architecture	No domain graphic available
Description	Zinc finger protein 206 (Zinc finger and SCAN domain-containing protein 10).