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Network neighborhood for query Sequence : RPGF6_HUMAN

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RPGF6_HUMAN
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPGF2_HUMAN
θ value	0 (rank : 1)	NC score	0.973553 (rank : 2)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	266	Target Neighborhood Hits	266	Shared Neighborhood Hits	266
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF4_HUMAN
θ value	4.71619e-41 (rank : 3)	NC score	0.677334 (rank : 5)
Query Neighborhood Hits	266	Target Neighborhood Hits	88	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	1.3722e-40 (rank : 4)	NC score	0.676347 (rank : 6)
Query Neighborhood Hits	266	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_MOUSE
θ value	1.51715e-39 (rank : 5)	NC score	0.700217 (rank : 4)
Query Neighborhood Hits	266	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	4.41421e-39 (rank : 6)	NC score	0.710408 (rank : 3)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF3_HUMAN
θ value	5.0505e-35 (rank : 7)	NC score	0.662897 (rank : 7)
Query Neighborhood Hits	266	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	9.52487e-34 (rank : 8)	NC score	0.649147 (rank : 8)
Query Neighborhood Hits	266	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF1_HUMAN
θ value	1.2077e-20 (rank : 9)	NC score	0.638471 (rank : 9)
Query Neighborhood Hits	266	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_MOUSE
θ value	7.32683e-18 (rank : 10)	NC score	0.474947 (rank : 26)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
θ value	1.63225e-17 (rank : 11)	NC score	0.485388 (rank : 19)
Query Neighborhood Hits	266	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_HUMAN
θ value	1.80466e-16 (rank : 12)	NC score	0.481745 (rank : 23)
Query Neighborhood Hits	266	Target Neighborhood Hits	274	Shared Neighborhood Hits	30
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	1.80466e-16 (rank : 13)	NC score	0.482520 (rank : 21)
Query Neighborhood Hits	266	Target Neighborhood Hits	281	Shared Neighborhood Hits	29
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS2_HUMAN
θ value	3.40345e-15 (rank : 14)	NC score	0.498918 (rank : 16)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

WHRN_MOUSE
θ value	3.40345e-15 (rank : 15)	NC score	0.504695 (rank : 13)
Query Neighborhood Hits	266	Target Neighborhood Hits	412	Shared Neighborhood Hits	172
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WHRN_HUMAN
θ value	7.58209e-15 (rank : 16)	NC score	0.509514 (rank : 12)
Query Neighborhood Hits	266	Target Neighborhood Hits	325	Shared Neighborhood Hits	169
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

RGL1_HUMAN
θ value	1.09485e-13 (rank : 17)	NC score	0.512163 (rank : 11)
Query Neighborhood Hits	266	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	1.42992e-13 (rank : 18)	NC score	0.494152 (rank : 17)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_HUMAN
θ value	2.43908e-13 (rank : 19)	NC score	0.482446 (rank : 22)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	32
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_MOUSE
θ value	5.43371e-13 (rank : 20)	NC score	0.489468 (rank : 18)
Query Neighborhood Hits	266	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GRP3_HUMAN
θ value	5.43371e-13 (rank : 21)	NC score	0.454885 (rank : 28)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PDZD7_HUMAN
θ value	6.00763e-12 (rank : 22)	NC score	0.518237 (rank : 10)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	155
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

RGL2_MOUSE
θ value	2.52405e-10 (rank : 23)	NC score	0.484946 (rank : 20)
Query Neighborhood Hits	266	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
θ value	1.63604e-09 (rank : 24)	NC score	0.481740 (rank : 24)
Query Neighborhood Hits	266	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

USH1C_HUMAN
θ value	8.11959e-09 (rank : 25)	NC score	0.477108 (rank : 25)
Query Neighborhood Hits	266	Target Neighborhood Hits	327	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZ11_MOUSE
θ value	1.80886e-08 (rank : 26)	NC score	0.502555 (rank : 15)
Query Neighborhood Hits	266	Target Neighborhood Hits	154	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

USH1C_MOUSE
θ value	3.08544e-08 (rank : 27)	NC score	0.444829 (rank : 30)
Query Neighborhood Hits	266	Target Neighborhood Hits	557	Shared Neighborhood Hits	172
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

PDZ11_HUMAN
θ value	4.0297e-08 (rank : 28)	NC score	0.502719 (rank : 14)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	139
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LIN7B_MOUSE
θ value	1.29631e-06 (rank : 29)	NC score	0.444281 (rank : 31)
Query Neighborhood Hits	266	Target Neighborhood Hits	200	Shared Neighborhood Hits	155
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

RGDSR_HUMAN
θ value	1.69304e-06 (rank : 30)	NC score	0.425920 (rank : 36)
Query Neighborhood Hits	266	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

LIN7B_HUMAN
θ value	2.21117e-06 (rank : 31)	NC score	0.446271 (rank : 29)
Query Neighborhood Hits	266	Target Neighborhood Hits	200	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7C_HUMAN
θ value	2.21117e-06 (rank : 32)	NC score	0.442632 (rank : 34)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	2.21117e-06 (rank : 33)	NC score	0.442632 (rank : 35)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

ZO3_MOUSE
θ value	6.43352e-06 (rank : 34)	NC score	0.370475 (rank : 49)
Query Neighborhood Hits	266	Target Neighborhood Hits	224	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

K1849_MOUSE
θ value	1.09739e-05 (rank : 35)	NC score	0.303741 (rank : 89)
Query Neighborhood Hits	266	Target Neighborhood Hits	335	Shared Neighborhood Hits	131
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

LIN7A_HUMAN
θ value	1.09739e-05 (rank : 36)	NC score	0.443179 (rank : 33)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	152
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	1.09739e-05 (rank : 37)	NC score	0.443306 (rank : 32)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	152
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

SYJ2B_HUMAN
θ value	1.43324e-05 (rank : 38)	NC score	0.455620 (rank : 27)
Query Neighborhood Hits	266	Target Neighborhood Hits	162	Shared Neighborhood Hits	142
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

ZO3_HUMAN
θ value	1.87187e-05 (rank : 39)	NC score	0.361822 (rank : 51)
Query Neighborhood Hits	266	Target Neighborhood Hits	219	Shared Neighborhood Hits	145
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PTN13_HUMAN
θ value	2.44474e-05 (rank : 40)	NC score	0.234078 (rank : 128)
Query Neighborhood Hits	266	Target Neighborhood Hits	471	Shared Neighborhood Hits	157
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

NHERF_MOUSE
θ value	4.1701e-05 (rank : 41)	NC score	0.414360 (rank : 37)
Query Neighborhood Hits	266	Target Neighborhood Hits	195	Shared Neighborhood Hits	150
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

PDZD2_HUMAN
θ value	4.1701e-05 (rank : 42)	NC score	0.361471 (rank : 53)
Query Neighborhood Hits	266	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

DLG3_HUMAN
θ value	7.1131e-05 (rank : 43)	NC score	0.344341 (rank : 59)
Query Neighborhood Hits	266	Target Neighborhood Hits	269	Shared Neighborhood Hits	147
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	7.1131e-05 (rank : 44)	NC score	0.344494 (rank : 58)
Query Neighborhood Hits	266	Target Neighborhood Hits	274	Shared Neighborhood Hits	147
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

NHRF2_HUMAN
θ value	7.1131e-05 (rank : 45)	NC score	0.403789 (rank : 39)
Query Neighborhood Hits	266	Target Neighborhood Hits	197	Shared Neighborhood Hits	157
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

K1849_HUMAN
θ value	0.000121331 (rank : 46)	NC score	0.298878 (rank : 91)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

ARHGB_HUMAN
θ value	0.000158464 (rank : 47)	NC score	0.248433 (rank : 122)
Query Neighborhood Hits	266	Target Neighborhood Hits	375	Shared Neighborhood Hits	150
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

MPDZ_MOUSE
θ value	0.000158464 (rank : 48)	NC score	0.381691 (rank : 43)
Query Neighborhood Hits	266	Target Neighborhood Hits	298	Shared Neighborhood Hits	162
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

NHERF_HUMAN
θ value	0.000158464 (rank : 49)	NC score	0.408312 (rank : 38)
Query Neighborhood Hits	266	Target Neighborhood Hits	190	Shared Neighborhood Hits	150
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

LAP4_HUMAN
θ value	0.00020696 (rank : 50)	NC score	0.261461 (rank : 105)
Query Neighborhood Hits	266	Target Neighborhood Hits	608	Shared Neighborhood Hits	163
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

NHRF2_MOUSE
θ value	0.00020696 (rank : 51)	NC score	0.399086 (rank : 40)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

MAGI1_HUMAN
θ value	0.00035302 (rank : 52)	NC score	0.359120 (rank : 54)
Query Neighborhood Hits	266	Target Neighborhood Hits	388	Shared Neighborhood Hits	165
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MPDZ_HUMAN
θ value	0.00035302 (rank : 53)	NC score	0.375936 (rank : 47)
Query Neighborhood Hits	266	Target Neighborhood Hits	261	Shared Neighborhood Hits	161
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PTN13_MOUSE
θ value	0.00035302 (rank : 54)	NC score	0.227538 (rank : 133)
Query Neighborhood Hits	266	Target Neighborhood Hits	426	Shared Neighborhood Hits	155
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

CT152_HUMAN
θ value	0.000602161 (rank : 55)	NC score	0.214281 (rank : 141)
Query Neighborhood Hits	266	Target Neighborhood Hits	30	Shared Neighborhood Hits	15
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

DLG2_HUMAN
θ value	0.000602161 (rank : 56)	NC score	0.336610 (rank : 64)
Query Neighborhood Hits	266	Target Neighborhood Hits	279	Shared Neighborhood Hits	145
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG5_HUMAN
θ value	0.000602161 (rank : 57)	NC score	0.247284 (rank : 124)
Query Neighborhood Hits	266	Target Neighborhood Hits	1088	Shared Neighborhood Hits	159
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

LDB3_HUMAN
θ value	0.000602161 (rank : 58)	NC score	0.178563 (rank : 152)
Query Neighborhood Hits	266	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	0.000602161 (rank : 59)	NC score	0.179893 (rank : 151)
Query Neighborhood Hits	266	Target Neighborhood Hits	510	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

ZO2_HUMAN
θ value	0.000602161 (rank : 60)	NC score	0.330562 (rank : 70)
Query Neighborhood Hits	266	Target Neighborhood Hits	289	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	0.000602161 (rank : 61)	NC score	0.331441 (rank : 68)
Query Neighborhood Hits	266	Target Neighborhood Hits	296	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DLG2_MOUSE
θ value	0.000786445 (rank : 62)	NC score	0.336975 (rank : 62)
Query Neighborhood Hits	266	Target Neighborhood Hits	271	Shared Neighborhood Hits	143
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_HUMAN
θ value	0.000786445 (rank : 63)	NC score	0.347284 (rank : 57)
Query Neighborhood Hits	266	Target Neighborhood Hits	286	Shared Neighborhood Hits	152
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.000786445 (rank : 64)	NC score	0.348003 (rank : 56)
Query Neighborhood Hits	266	Target Neighborhood Hits	282	Shared Neighborhood Hits	152
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

GOPC_HUMAN
θ value	0.000786445 (rank : 65)	NC score	0.361803 (rank : 52)
Query Neighborhood Hits	266	Target Neighborhood Hits	377	Shared Neighborhood Hits	143
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	0.000786445 (rank : 66)	NC score	0.367244 (rank : 50)
Query Neighborhood Hits	266	Target Neighborhood Hits	323	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

ZO1_HUMAN
θ value	0.000786445 (rank : 67)	NC score	0.322153 (rank : 79)
Query Neighborhood Hits	266	Target Neighborhood Hits	474	Shared Neighborhood Hits	149
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO1_MOUSE
θ value	0.000786445 (rank : 68)	NC score	0.326954 (rank : 74)
Query Neighborhood Hits	266	Target Neighborhood Hits	453	Shared Neighborhood Hits	154
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

INADL_HUMAN
θ value	0.00134147 (rank : 69)	NC score	0.374660 (rank : 48)
Query Neighborhood Hits	266	Target Neighborhood Hits	260	Shared Neighborhood Hits	156
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LAP4_MOUSE
θ value	0.00134147 (rank : 70)	NC score	0.255194 (rank : 110)
Query Neighborhood Hits	266	Target Neighborhood Hits	590	Shared Neighborhood Hits	161
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

SYNP2_MOUSE
θ value	0.00134147 (rank : 71)	NC score	0.270782 (rank : 102)
Query Neighborhood Hits	266	Target Neighborhood Hits	252	Shared Neighborhood Hits	114
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

PDLI7_HUMAN
θ value	0.00175202 (rank : 72)	NC score	0.175612 (rank : 154)
Query Neighborhood Hits	266	Target Neighborhood Hits	547	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD1_MOUSE
θ value	0.00175202 (rank : 73)	NC score	0.387319 (rank : 42)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	148
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SYP2L_HUMAN
θ value	0.00228821 (rank : 74)	NC score	0.278329 (rank : 98)
Query Neighborhood Hits	266	Target Neighborhood Hits	400	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

ARHGC_HUMAN
θ value	0.00298849 (rank : 75)	NC score	0.210367 (rank : 145)
Query Neighborhood Hits	266	Target Neighborhood Hits	351	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	0.00298849 (rank : 76)	NC score	0.210608 (rank : 144)
Query Neighborhood Hits	266	Target Neighborhood Hits	344	Shared Neighborhood Hits	138
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

MAGI1_MOUSE
θ value	0.00298849 (rank : 77)	NC score	0.351231 (rank : 55)
Query Neighborhood Hits	266	Target Neighborhood Hits	403	Shared Neighborhood Hits	161
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

RHPN1_HUMAN
θ value	0.00298849 (rank : 78)	NC score	0.246221 (rank : 126)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PDZD1_HUMAN
θ value	0.00390308 (rank : 79)	NC score	0.389979 (rank : 41)
Query Neighborhood Hits	266	Target Neighborhood Hits	190	Shared Neighborhood Hits	152
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DVL2_HUMAN
θ value	0.00509761 (rank : 80)	NC score	0.251775 (rank : 118)
Query Neighborhood Hits	266	Target Neighborhood Hits	223	Shared Neighborhood Hits	99
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	0.00509761 (rank : 81)	NC score	0.251924 (rank : 117)
Query Neighborhood Hits	266	Target Neighborhood Hits	233	Shared Neighborhood Hits	97
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PDLI7_MOUSE
θ value	0.00509761 (rank : 82)	NC score	0.168599 (rank : 160)
Query Neighborhood Hits	266	Target Neighborhood Hits	279	Shared Neighborhood Hits	98
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZK4_HUMAN
θ value	0.00509761 (rank : 83)	NC score	0.256388 (rank : 109)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	107
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PAR6G_HUMAN
θ value	0.00665767 (rank : 84)	NC score	0.251370 (rank : 120)
Query Neighborhood Hits	266	Target Neighborhood Hits	159	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
θ value	0.00665767 (rank : 85)	NC score	0.249861 (rank : 121)
Query Neighborhood Hits	266	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PDZK4_MOUSE
θ value	0.00665767 (rank : 86)	NC score	0.259985 (rank : 107)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

SYNP2_HUMAN
θ value	0.00665767 (rank : 87)	NC score	0.240195 (rank : 127)
Query Neighborhood Hits	266	Target Neighborhood Hits	323	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

INADL_MOUSE
θ value	0.00869519 (rank : 88)	NC score	0.377991 (rank : 46)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	161
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MAGI2_HUMAN
θ value	0.00869519 (rank : 89)	NC score	0.336970 (rank : 63)
Query Neighborhood Hits	266	Target Neighborhood Hits	373	Shared Neighborhood Hits	155
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	0.00869519 (rank : 90)	NC score	0.335325 (rank : 66)
Query Neighborhood Hits	266	Target Neighborhood Hits	370	Shared Neighborhood Hits	154
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PAR6B_HUMAN
θ value	0.00869519 (rank : 91)	NC score	0.252517 (rank : 116)
Query Neighborhood Hits	266	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PDLI1_HUMAN
θ value	0.00869519 (rank : 92)	NC score	0.230075 (rank : 130)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	100
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

MAST4_HUMAN
θ value	0.0113563 (rank : 93)	NC score	0.045275 (rank : 236)
Query Neighborhood Hits	266	Target Neighborhood Hits	1804	Shared Neighborhood Hits	131
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ANK2_HUMAN
θ value	0.0148317 (rank : 94)	NC score	0.029137 (rank : 251)
Query Neighborhood Hits	266	Target Neighborhood Hits	1615	Shared Neighborhood Hits	58
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CT152_MOUSE
θ value	0.0148317 (rank : 95)	NC score	0.174437 (rank : 156)
Query Neighborhood Hits	266	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KAP1_HUMAN
θ value	0.0148317 (rank : 96)	NC score	0.124924 (rank : 184)
Query Neighborhood Hits	266	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

PAR6B_MOUSE
θ value	0.0148317 (rank : 97)	NC score	0.251430 (rank : 119)
Query Neighborhood Hits	266	Target Neighborhood Hits	128	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PDLI4_HUMAN
θ value	0.0148317 (rank : 98)	NC score	0.230020 (rank : 131)
Query Neighborhood Hits	266	Target Neighborhood Hits	245	Shared Neighborhood Hits	105
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	0.0148317 (rank : 99)	NC score	0.233372 (rank : 129)
Query Neighborhood Hits	266	Target Neighborhood Hits	233	Shared Neighborhood Hits	107
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

DVL3_HUMAN
θ value	0.0193708 (rank : 100)	NC score	0.253615 (rank : 113)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	94
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.0193708 (rank : 101)	NC score	0.253133 (rank : 115)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	94
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PZRN4_HUMAN
θ value	0.0193708 (rank : 102)	NC score	0.298770 (rank : 92)
Query Neighborhood Hits	266	Target Neighborhood Hits	438	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RHPN1_MOUSE
θ value	0.0193708 (rank : 103)	NC score	0.247077 (rank : 125)
Query Neighborhood Hits	266	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SDCB1_HUMAN
θ value	0.0193708 (rank : 104)	NC score	0.265020 (rank : 104)
Query Neighborhood Hits	266	Target Neighborhood Hits	150	Shared Neighborhood Hits	121
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.0193708 (rank : 105)	NC score	0.266361 (rank : 103)
Query Neighborhood Hits	266	Target Neighborhood Hits	144	Shared Neighborhood Hits	115
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

CAR14_MOUSE
θ value	0.0252991 (rank : 106)	NC score	0.084114 (rank : 203)
Query Neighborhood Hits	266	Target Neighborhood Hits	526	Shared Neighborhood Hits	41
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

PARD3_HUMAN
θ value	0.0252991 (rank : 107)	NC score	0.334780 (rank : 67)
Query Neighborhood Hits	266	Target Neighborhood Hits	312	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

SHAN1_HUMAN
θ value	0.0252991 (rank : 108)	NC score	0.134014 (rank : 182)
Query Neighborhood Hits	266	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SNTG2_HUMAN
θ value	0.0252991 (rank : 109)	NC score	0.340582 (rank : 61)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTG2_MOUSE
θ value	0.0252991 (rank : 110)	NC score	0.325635 (rank : 76)
Query Neighborhood Hits	266	Target Neighborhood Hits	176	Shared Neighborhood Hits	143
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

DLG1_HUMAN
θ value	0.0330416 (rank : 111)	NC score	0.329151 (rank : 73)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	144
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

DLG1_MOUSE
θ value	0.0330416 (rank : 112)	NC score	0.326601 (rank : 75)
Query Neighborhood Hits	266	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

IL16_MOUSE
θ value	0.0330416 (rank : 113)	NC score	0.316991 (rank : 80)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	119
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LAP2_HUMAN
θ value	0.0330416 (rank : 114)	NC score	0.142153 (rank : 178)
Query Neighborhood Hits	266	Target Neighborhood Hits	499	Shared Neighborhood Hits	102
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.0330416 (rank : 115)	NC score	0.136666 (rank : 180)
Query Neighborhood Hits	266	Target Neighborhood Hits	482	Shared Neighborhood Hits	102
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LNX2_HUMAN
θ value	0.0330416 (rank : 116)	NC score	0.324373 (rank : 78)
Query Neighborhood Hits	266	Target Neighborhood Hits	389	Shared Neighborhood Hits	149
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	0.0330416 (rank : 117)	NC score	0.330448 (rank : 71)
Query Neighborhood Hits	266	Target Neighborhood Hits	407	Shared Neighborhood Hits	149
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

DVL1L_HUMAN
θ value	0.0431538 (rank : 118)	NC score	0.247986 (rank : 123)
Query Neighborhood Hits	266	Target Neighborhood Hits	146	Shared Neighborhood Hits	98
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
θ value	0.0431538 (rank : 119)	NC score	0.254459 (rank : 112)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	99
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL1_MOUSE
θ value	0.0431538 (rank : 120)	NC score	0.253535 (rank : 114)
Query Neighborhood Hits	266	Target Neighborhood Hits	146	Shared Neighborhood Hits	97
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

KIF4A_MOUSE
θ value	0.0431538 (rank : 121)	NC score	0.013912 (rank : 272)
Query Neighborhood Hits	266	Target Neighborhood Hits	1033	Shared Neighborhood Hits	27
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

SHAN2_HUMAN
θ value	0.0431538 (rank : 122)	NC score	0.218069 (rank : 139)
Query Neighborhood Hits	266	Target Neighborhood Hits	346	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	0.0563607 (rank : 123)	NC score	0.198702 (rank : 148)
Query Neighborhood Hits	266	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

AFAD_HUMAN
θ value	0.0736092 (rank : 124)	NC score	0.260655 (rank : 106)
Query Neighborhood Hits	266	Target Neighborhood Hits	689	Shared Neighborhood Hits	134
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

KAP1_MOUSE
θ value	0.0736092 (rank : 125)	NC score	0.120340 (rank : 185)
Query Neighborhood Hits	266	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

PARD3_MOUSE
θ value	0.0736092 (rank : 126)	NC score	0.336584 (rank : 65)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	140
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDLI3_HUMAN
θ value	0.0736092 (rank : 127)	NC score	0.219473 (rank : 138)
Query Neighborhood Hits	266	Target Neighborhood Hits	199	Shared Neighborhood Hits	105
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SNTB2_HUMAN
θ value	0.0736092 (rank : 128)	NC score	0.307369 (rank : 86)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	133
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	0.0736092 (rank : 129)	NC score	0.307531 (rank : 85)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	133
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

LRRC7_HUMAN
θ value	0.0961366 (rank : 130)	NC score	0.150813 (rank : 174)
Query Neighborhood Hits	266	Target Neighborhood Hits	423	Shared Neighborhood Hits	117
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	0.0961366 (rank : 131)	NC score	0.150013 (rank : 175)
Query Neighborhood Hits	266	Target Neighborhood Hits	416	Shared Neighborhood Hits	113
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

MAST3_HUMAN
θ value	0.0961366 (rank : 132)	NC score	0.040424 (rank : 242)
Query Neighborhood Hits	266	Target Neighborhood Hits	1128	Shared Neighborhood Hits	106
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

CEP35_HUMAN
θ value	0.125558 (rank : 133)	NC score	0.041199 (rank : 239)
Query Neighborhood Hits	266	Target Neighborhood Hits	811	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

EPC2_MOUSE
θ value	0.125558 (rank : 134)	NC score	0.039211 (rank : 244)
Query Neighborhood Hits	266	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0I4, Q3URX9, Q80Y70, Q8BXC5	Gene names	Epc2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

IL16_HUMAN
θ value	0.125558 (rank : 135)	NC score	0.324809 (rank : 77)
Query Neighborhood Hits	266	Target Neighborhood Hits	207	Shared Neighborhood Hits	123
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

KAP2_MOUSE
θ value	0.125558 (rank : 136)	NC score	0.111486 (rank : 187)
Query Neighborhood Hits	266	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

MY18A_MOUSE
θ value	0.125558 (rank : 137)	NC score	0.051655 (rank : 229)
Query Neighborhood Hits	266	Target Neighborhood Hits	1989	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

HTRA3_MOUSE
θ value	0.163984 (rank : 138)	NC score	0.093291 (rank : 201)
Query Neighborhood Hits	266	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

MAST2_MOUSE
θ value	0.163984 (rank : 139)	NC score	0.040486 (rank : 241)
Query Neighborhood Hits	266	Target Neighborhood Hits	1110	Shared Neighborhood Hits	110
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PAR6A_HUMAN
θ value	0.163984 (rank : 140)	NC score	0.227067 (rank : 134)
Query Neighborhood Hits	266	Target Neighborhood Hits	119	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	0.163984 (rank : 141)	NC score	0.227801 (rank : 132)
Query Neighborhood Hits	266	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PDLI1_MOUSE
θ value	0.163984 (rank : 142)	NC score	0.215426 (rank : 140)
Query Neighborhood Hits	266	Target Neighborhood Hits	213	Shared Neighborhood Hits	97
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_MOUSE
θ value	0.21417 (rank : 143)	NC score	0.210864 (rank : 143)
Query Neighborhood Hits	266	Target Neighborhood Hits	197	Shared Neighborhood Hits	100
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SNTA1_HUMAN
θ value	0.21417 (rank : 144)	NC score	0.301966 (rank : 90)
Query Neighborhood Hits	266	Target Neighborhood Hits	186	Shared Neighborhood Hits	135
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

KAP3_MOUSE
θ value	0.279714 (rank : 145)	NC score	0.108814 (rank : 188)
Query Neighborhood Hits	266	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

MAST2_HUMAN
θ value	0.279714 (rank : 146)	NC score	0.040848 (rank : 240)
Query Neighborhood Hits	266	Target Neighborhood Hits	1189	Shared Neighborhood Hits	110
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ORC2_HUMAN
θ value	0.279714 (rank : 147)	NC score	0.035049 (rank : 249)
Query Neighborhood Hits	266	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q13416, Q13204	Gene names	ORC2L, ORC2
Domain Architecture
Description	Origin recognition complex subunit 2.

PSCBP_HUMAN
θ value	0.279714 (rank : 148)	NC score	0.220176 (rank : 137)
Query Neighborhood Hits	266	Target Neighborhood Hits	123	Shared Neighborhood Hits	105
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SDCB2_HUMAN
θ value	0.279714 (rank : 149)	NC score	0.205992 (rank : 146)
Query Neighborhood Hits	266	Target Neighborhood Hits	121	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SNTG1_HUMAN
θ value	0.279714 (rank : 150)	NC score	0.314709 (rank : 81)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	142
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

TX1B3_HUMAN
θ value	0.279714 (rank : 151)	NC score	0.380979 (rank : 44)
Query Neighborhood Hits	266	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	0.279714 (rank : 152)	NC score	0.380866 (rank : 45)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	144
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

KAP3_HUMAN
θ value	0.365318 (rank : 153)	NC score	0.107476 (rank : 190)
Query Neighborhood Hits	266	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

LNX1_MOUSE
θ value	0.365318 (rank : 154)	NC score	0.306081 (rank : 88)
Query Neighborhood Hits	266	Target Neighborhood Hits	377	Shared Neighborhood Hits	145
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

PDZD3_HUMAN
θ value	0.365318 (rank : 155)	NC score	0.342258 (rank : 60)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	142
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SNTG1_MOUSE
θ value	0.365318 (rank : 156)	NC score	0.314591 (rank : 82)
Query Neighborhood Hits	266	Target Neighborhood Hits	179	Shared Neighborhood Hits	142
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

CAR14_HUMAN
θ value	0.47712 (rank : 157)	NC score	0.071998 (rank : 214)
Query Neighborhood Hits	266	Target Neighborhood Hits	449	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

EGR2_MOUSE
θ value	0.47712 (rank : 158)	NC score	-0.003473 (rank : 314)
Query Neighborhood Hits	266	Target Neighborhood Hits	745	Shared Neighborhood Hits	5
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

PDLI2_MOUSE
θ value	0.47712 (rank : 159)	NC score	0.278663 (rank : 97)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PTN4_HUMAN
θ value	0.47712 (rank : 160)	NC score	0.096541 (rank : 199)
Query Neighborhood Hits	266	Target Neighborhood Hits	303	Shared Neighborhood Hits	120
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PZRN3_HUMAN
θ value	0.47712 (rank : 161)	NC score	0.295543 (rank : 95)
Query Neighborhood Hits	266	Target Neighborhood Hits	461	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	0.47712 (rank : 162)	NC score	0.297388 (rank : 93)
Query Neighborhood Hits	266	Target Neighborhood Hits	447	Shared Neighborhood Hits	136
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

DOK1_HUMAN
θ value	0.62314 (rank : 163)	NC score	0.028047 (rank : 252)
Query Neighborhood Hits	266	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

MGRN1_HUMAN
θ value	0.62314 (rank : 164)	NC score	0.026769 (rank : 254)
Query Neighborhood Hits	266	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

PAR3L_HUMAN
θ value	0.62314 (rank : 165)	NC score	0.331083 (rank : 69)
Query Neighborhood Hits	266	Target Neighborhood Hits	297	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

SNTA1_MOUSE
θ value	0.62314 (rank : 166)	NC score	0.290879 (rank : 96)
Query Neighborhood Hits	266	Target Neighborhood Hits	170	Shared Neighborhood Hits	131
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

TRAIP_HUMAN
θ value	0.62314 (rank : 167)	NC score	0.017780 (rank : 264)
Query Neighborhood Hits	266	Target Neighborhood Hits	780	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

CAR11_HUMAN
θ value	0.813845 (rank : 168)	NC score	0.074282 (rank : 211)
Query Neighborhood Hits	266	Target Neighborhood Hits	690	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

EPC2_HUMAN
θ value	0.813845 (rank : 169)	NC score	0.034359 (rank : 250)
Query Neighborhood Hits	266	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

IGSF2_HUMAN
θ value	0.813845 (rank : 170)	NC score	0.020131 (rank : 261)
Query Neighborhood Hits	266	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

NEB1_HUMAN
θ value	0.813845 (rank : 171)	NC score	0.203757 (rank : 147)
Query Neighborhood Hits	266	Target Neighborhood Hits	829	Shared Neighborhood Hits	115
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PDLI2_HUMAN
θ value	0.813845 (rank : 172)	NC score	0.272691 (rank : 101)
Query Neighborhood Hits	266	Target Neighborhood Hits	245	Shared Neighborhood Hits	123
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

SDCB2_MOUSE
θ value	0.813845 (rank : 173)	NC score	0.212246 (rank : 142)
Query Neighborhood Hits	266	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

HTRA3_HUMAN
θ value	1.06291 (rank : 174)	NC score	0.082533 (rank : 205)
Query Neighborhood Hits	266	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

KAP2_HUMAN
θ value	1.06291 (rank : 175)	NC score	0.103792 (rank : 194)
Query Neighborhood Hits	266	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

LIMK1_HUMAN
θ value	1.06291 (rank : 176)	NC score	0.021556 (rank : 258)
Query Neighborhood Hits	266	Target Neighborhood Hits	1005	Shared Neighborhood Hits	69
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	1.06291 (rank : 177)	NC score	0.021055 (rank : 259)
Query Neighborhood Hits	266	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

PDZD3_MOUSE
θ value	1.06291 (rank : 178)	NC score	0.330418 (rank : 72)
Query Neighborhood Hits	266	Target Neighborhood Hits	171	Shared Neighborhood Hits	141
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

SYP2L_MOUSE
θ value	1.06291 (rank : 179)	NC score	0.221325 (rank : 136)
Query Neighborhood Hits	266	Target Neighborhood Hits	289	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TSH1_HUMAN
θ value	1.06291 (rank : 180)	NC score	0.014655 (rank : 269)
Query Neighborhood Hits	266	Target Neighborhood Hits	558	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

MYO6_HUMAN
θ value	1.38821 (rank : 181)	NC score	0.008114 (rank : 298)
Query Neighborhood Hits	266	Target Neighborhood Hits	727	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

PREX1_HUMAN
θ value	1.38821 (rank : 182)	NC score	0.140173 (rank : 179)
Query Neighborhood Hits	266	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RAI1_MOUSE
θ value	1.38821 (rank : 183)	NC score	0.018545 (rank : 263)
Query Neighborhood Hits	266	Target Neighborhood Hits	344	Shared Neighborhood Hits	11
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SAMN1_MOUSE
θ value	1.38821 (rank : 184)	NC score	0.017355 (rank : 265)
Query Neighborhood Hits	266	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SI1L2_HUMAN
θ value	1.38821 (rank : 185)	NC score	0.047294 (rank : 235)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

TPR_HUMAN
θ value	1.38821 (rank : 186)	NC score	0.012806 (rank : 277)
Query Neighborhood Hits	266	Target Neighborhood Hits	1921	Shared Neighborhood Hits	55
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CN145_MOUSE
θ value	1.81305 (rank : 187)	NC score	0.010713 (rank : 286)
Query Neighborhood Hits	266	Target Neighborhood Hits	916	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

DOK1_MOUSE
θ value	1.81305 (rank : 188)	NC score	0.025066 (rank : 256)
Query Neighborhood Hits	266	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

GOGA1_MOUSE
θ value	1.81305 (rank : 189)	NC score	0.011292 (rank : 283)
Query Neighborhood Hits	266	Target Neighborhood Hits	994	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GRIP2_HUMAN
θ value	1.81305 (rank : 190)	NC score	0.310798 (rank : 83)
Query Neighborhood Hits	266	Target Neighborhood Hits	256	Shared Neighborhood Hits	158
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

HDAC9_HUMAN
θ value	1.81305 (rank : 191)	NC score	0.009369 (rank : 291)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

MY18A_HUMAN
θ value	1.81305 (rank : 192)	NC score	0.044818 (rank : 237)
Query Neighborhood Hits	266	Target Neighborhood Hits	1929	Shared Neighborhood Hits	138
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NOS1_HUMAN
θ value	1.81305 (rank : 193)	NC score	0.148877 (rank : 177)
Query Neighborhood Hits	266	Target Neighborhood Hits	218	Shared Neighborhood Hits	117
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOTC1_MOUSE
θ value	1.81305 (rank : 194)	NC score	-0.000292 (rank : 310)
Query Neighborhood Hits	266	Target Neighborhood Hits	916	Shared Neighborhood Hits	12
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PSCBP_MOUSE
θ value	1.81305 (rank : 195)	NC score	0.226415 (rank : 135)
Query Neighborhood Hits	266	Target Neighborhood Hits	118	Shared Neighborhood Hits	108
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

TIAM1_HUMAN
θ value	1.81305 (rank : 196)	NC score	0.098573 (rank : 198)
Query Neighborhood Hits	266	Target Neighborhood Hits	225	Shared Neighborhood Hits	67
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

APXL_HUMAN
θ value	2.36792 (rank : 197)	NC score	0.185466 (rank : 149)
Query Neighborhood Hits	266	Target Neighborhood Hits	553	Shared Neighborhood Hits	91
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

FA47B_HUMAN
θ value	2.36792 (rank : 198)	NC score	0.022971 (rank : 257)
Query Neighborhood Hits	266	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GP158_HUMAN
θ value	2.36792 (rank : 199)	NC score	0.014640 (rank : 270)
Query Neighborhood Hits	266	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

GRASP_HUMAN
θ value	2.36792 (rank : 200)	NC score	0.258491 (rank : 108)
Query Neighborhood Hits	266	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	2.36792 (rank : 201)	NC score	0.255159 (rank : 111)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	112
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HUWE1_MOUSE
θ value	2.36792 (rank : 202)	NC score	0.012867 (rank : 276)
Query Neighborhood Hits	266	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

LNX1_HUMAN
θ value	2.36792 (rank : 203)	NC score	0.295655 (rank : 94)
Query Neighborhood Hits	266	Target Neighborhood Hits	379	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MAST1_HUMAN
θ value	2.36792 (rank : 204)	NC score	0.037166 (rank : 248)
Query Neighborhood Hits	266	Target Neighborhood Hits	1146	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	2.36792 (rank : 205)	NC score	0.037602 (rank : 247)
Query Neighborhood Hits	266	Target Neighborhood Hits	1123	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SNTB1_HUMAN
θ value	2.36792 (rank : 206)	NC score	0.275267 (rank : 99)
Query Neighborhood Hits	266	Target Neighborhood Hits	157	Shared Neighborhood Hits	123
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

BAZ2B_HUMAN
θ value	3.0926 (rank : 207)	NC score	0.011334 (rank : 281)
Query Neighborhood Hits	266	Target Neighborhood Hits	803	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CP135_MOUSE
θ value	3.0926 (rank : 208)	NC score	0.009309 (rank : 292)
Query Neighborhood Hits	266	Target Neighborhood Hits	1278	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GRIP1_MOUSE
θ value	3.0926 (rank : 209)	NC score	0.308035 (rank : 84)
Query Neighborhood Hits	266	Target Neighborhood Hits	241	Shared Neighborhood Hits	157
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

HUWE1_HUMAN
θ value	3.0926 (rank : 210)	NC score	0.011100 (rank : 284)
Query Neighborhood Hits	266	Target Neighborhood Hits	443	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

RHG04_HUMAN
θ value	3.0926 (rank : 211)	NC score	0.007427 (rank : 303)
Query Neighborhood Hits	266	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SI1L2_MOUSE
θ value	3.0926 (rank : 212)	NC score	0.044267 (rank : 238)
Query Neighborhood Hits	266	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

CALD1_HUMAN
θ value	4.03905 (rank : 213)	NC score	0.010768 (rank : 285)
Query Neighborhood Hits	266	Target Neighborhood Hits	959	Shared Neighborhood Hits	32
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

DOCK9_HUMAN
θ value	4.03905 (rank : 214)	NC score	0.007447 (rank : 302)
Query Neighborhood Hits	266	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

FOG2_HUMAN
θ value	4.03905 (rank : 215)	NC score	-0.000781 (rank : 311)
Query Neighborhood Hits	266	Target Neighborhood Hits	731	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

HTRA4_HUMAN
θ value	4.03905 (rank : 216)	NC score	0.048137 (rank : 234)
Query Neighborhood Hits	266	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

KU86_HUMAN
θ value	4.03905 (rank : 217)	NC score	0.014850 (rank : 267)
Query Neighborhood Hits	266	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P13010, Q4VBQ5, Q9UCQ0, Q9UCQ1	Gene names	XRCC5, G22P2
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 2 (EC 3.6.1.-) (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85) (Nuclear factor IV) (DNA-repair protein XRCC5).

LMO7_HUMAN
θ value	4.03905 (rank : 218)	NC score	0.086637 (rank : 202)
Query Neighborhood Hits	266	Target Neighborhood Hits	507	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

MLL3_HUMAN
θ value	4.03905 (rank : 219)	NC score	0.025677 (rank : 255)
Query Neighborhood Hits	266	Target Neighborhood Hits	1644	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NEK1_MOUSE
θ value	4.03905 (rank : 220)	NC score	-0.001000 (rank : 312)
Query Neighborhood Hits	266	Target Neighborhood Hits	1311	Shared Neighborhood Hits	27
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PSMD9_MOUSE
θ value	4.03905 (rank : 221)	NC score	0.068513 (rank : 217)
Query Neighborhood Hits	266	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

SNTB1_MOUSE
θ value	4.03905 (rank : 222)	NC score	0.273451 (rank : 100)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

TSH1_MOUSE
θ value	4.03905 (rank : 223)	NC score	0.009934 (rank : 289)
Query Neighborhood Hits	266	Target Neighborhood Hits	675	Shared Neighborhood Hits	7
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

ZCPW1_MOUSE
θ value	4.03905 (rank : 224)	NC score	0.018996 (rank : 262)
Query Neighborhood Hits	266	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

ZFP92_MOUSE
θ value	4.03905 (rank : 225)	NC score	-0.007277 (rank : 315)
Query Neighborhood Hits	266	Target Neighborhood Hits	731	Shared Neighborhood Hits	5
SwissProt Accessions	Q62396	Gene names	Zfp92
Domain Architecture
Description	Zinc finger protein 92 (Zfp-92).

ANTOL_HUMAN
θ value	5.27518 (rank : 226)	NC score	0.016659 (rank : 266)
Query Neighborhood Hits	266	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

GRIP1_HUMAN
θ value	5.27518 (rank : 227)	NC score	0.307267 (rank : 87)
Query Neighborhood Hits	266	Target Neighborhood Hits	231	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

HUCE1_MOUSE
θ value	5.27518 (rank : 228)	NC score	0.013378 (rank : 274)
Query Neighborhood Hits	266	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DB85, Q8BHW3	Gene names
Domain Architecture	No domain graphic available
Description	Cerebral protein 1 homolog.

JIP4_MOUSE
θ value	5.27518 (rank : 229)	NC score	0.013731 (rank : 273)
Query Neighborhood Hits	266	Target Neighborhood Hits	593	Shared Neighborhood Hits	22
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

KIF3C_HUMAN
θ value	5.27518 (rank : 230)	NC score	0.008339 (rank : 297)
Query Neighborhood Hits	266	Target Neighborhood Hits	478	Shared Neighborhood Hits	20
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

MDC1_HUMAN
θ value	5.27518 (rank : 231)	NC score	0.027279 (rank : 253)
Query Neighborhood Hits	266	Target Neighborhood Hits	1446	Shared Neighborhood Hits	55
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NEB2_HUMAN
θ value	5.27518 (rank : 232)	NC score	0.180050 (rank : 150)
Query Neighborhood Hits	266	Target Neighborhood Hits	883	Shared Neighborhood Hits	110
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	5.27518 (rank : 233)	NC score	0.177826 (rank : 153)
Query Neighborhood Hits	266	Target Neighborhood Hits	889	Shared Neighborhood Hits	111
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NKTR_HUMAN
θ value	5.27518 (rank : 234)	NC score	0.006511 (rank : 306)
Query Neighborhood Hits	266	Target Neighborhood Hits	658	Shared Neighborhood Hits	19
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PSMD9_HUMAN
θ value	5.27518 (rank : 235)	NC score	0.069679 (rank : 216)
Query Neighborhood Hits	266	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PTN3_HUMAN
θ value	5.27518 (rank : 236)	NC score	0.093359 (rank : 200)
Query Neighborhood Hits	266	Target Neighborhood Hits	258	Shared Neighborhood Hits	113
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

RHBD4_HUMAN
θ value	5.27518 (rank : 237)	NC score	0.008723 (rank : 295)
Query Neighborhood Hits	266	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P58872	Gene names	RHBDL4, VRHO
Domain Architecture
Description	Rhomboid-related protein 4 (EC 3.4.21.105) (Ventrhoid transmembrane protein).

RUSC2_HUMAN
θ value	5.27518 (rank : 238)	NC score	0.014757 (rank : 268)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

ATS17_HUMAN
θ value	6.88961 (rank : 239)	NC score	-0.000001 (rank : 309)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

CF150_HUMAN
θ value	6.88961 (rank : 240)	NC score	0.020463 (rank : 260)
Query Neighborhood Hits	266	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

CGRE1_MOUSE
θ value	6.88961 (rank : 241)	NC score	0.012116 (rank : 279)
Query Neighborhood Hits	266	Target Neighborhood Hits	173	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

GA2L1_MOUSE
θ value	6.88961 (rank : 242)	NC score	0.013107 (rank : 275)
Query Neighborhood Hits	266	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

JADE1_HUMAN
θ value	6.88961 (rank : 243)	NC score	0.007718 (rank : 300)
Query Neighborhood Hits	266	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

NIN_HUMAN
θ value	6.88961 (rank : 244)	NC score	0.009679 (rank : 290)
Query Neighborhood Hits	266	Target Neighborhood Hits	1416	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NRBF2_MOUSE
θ value	6.88961 (rank : 245)	NC score	0.014501 (rank : 271)
Query Neighborhood Hits	266	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VCQ3, Q9DCG3	Gene names	Nrbf2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2).

POLK_MOUSE
θ value	6.88961 (rank : 246)	NC score	0.008609 (rank : 296)
Query Neighborhood Hits	266	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

PRKDC_MOUSE
θ value	6.88961 (rank : 247)	NC score	0.009949 (rank : 288)
Query Neighborhood Hits	266	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

RHG18_HUMAN
θ value	6.88961 (rank : 248)	NC score	0.005874 (rank : 307)
Query Neighborhood Hits	266	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RPO3D_MOUSE
θ value	6.88961 (rank : 249)	NC score	0.012379 (rank : 278)
Query Neighborhood Hits	266	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WD1, Q9CZ02	Gene names	Polr3d, Bn51t
Domain Architecture
Description	DNA-directed RNA polymerase III subunit D (EC 2.7.7.6) (DNA-directed RNA polymerase III 47 kDa polypeptide) (RNA polymerase C subunit 4) (RPC4).

SIA7A_HUMAN
θ value	6.88961 (rank : 250)	NC score	0.007579 (rank : 301)
Query Neighborhood Hits	266	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

SNX14_MOUSE
θ value	6.88961 (rank : 251)	NC score	0.010304 (rank : 287)
Query Neighborhood Hits	266	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

TIAM1_MOUSE
θ value	6.88961 (rank : 252)	NC score	0.079484 (rank : 209)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CE290_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.006638 (rank : 305)
Query Neighborhood Hits	266	Target Neighborhood Hits	1553	Shared Neighborhood Hits	39
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

DSG3_MOUSE
θ value	8.99809 (rank : 254)	NC score	-0.001672 (rank : 313)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	2
SwissProt Accessions	O35902, Q8CB02, Q8CE48	Gene names	Dsg3
Domain Architecture	No domain graphic available
Description	Desmoglein-3 precursor (130 kDa pemphigus vulgaris antigen homolog).

GA2L2_HUMAN
θ value	8.99809 (rank : 255)	NC score	0.011532 (rank : 280)
Query Neighborhood Hits	266	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

GRLF1_HUMAN
θ value	8.99809 (rank : 256)	NC score	0.004132 (rank : 308)
Query Neighborhood Hits	266	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

JADE1_MOUSE
θ value	8.99809 (rank : 257)	NC score	0.007105 (rank : 304)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

KAP0_HUMAN
θ value	8.99809 (rank : 258)	NC score	0.101864 (rank : 196)
Query Neighborhood Hits	266	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.102382 (rank : 195)
Query Neighborhood Hits	266	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KCNH6_HUMAN
θ value	8.99809 (rank : 260)	NC score	0.008082 (rank : 299)
Query Neighborhood Hits	266	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

PCNT_HUMAN
θ value	8.99809 (rank : 261)	NC score	0.011301 (rank : 282)
Query Neighborhood Hits	266	Target Neighborhood Hits	1551	Shared Neighborhood Hits	40
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PUM1_HUMAN
θ value	8.99809 (rank : 262)	NC score	0.009124 (rank : 293)
Query Neighborhood Hits	266	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q14671, Q5VXY7, Q9HAN1	Gene names	PUM1, KIAA0099, PUMH1
Domain Architecture
Description	Pumilio homolog 1 (Pumilio-1) (HsPUM).

PUM1_MOUSE
θ value	8.99809 (rank : 263)	NC score	0.009096 (rank : 294)
Query Neighborhood Hits	266	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U78, Q80X96, Q80YU8, Q8BPV7, Q9EPU6	Gene names	Pum1, Kiaa0099
Domain Architecture
Description	Pumilio homolog 1.

SI1L1_HUMAN
θ value	8.99809 (rank : 264)	NC score	0.038465 (rank : 245)
Query Neighborhood Hits	266	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	8.99809 (rank : 265)	NC score	0.037871 (rank : 246)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SIPA1_HUMAN
θ value	8.99809 (rank : 266)	NC score	0.039251 (rank : 243)
Query Neighborhood Hits	266	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

APBA1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.168373 (rank : 162)
Query Neighborhood Hits	266	Target Neighborhood Hits	325	Shared Neighborhood Hits	125
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.166760 (rank : 163)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	122
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.165399 (rank : 164)
Query Neighborhood Hits	266	Target Neighborhood Hits	219	Shared Neighborhood Hits	121
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.161287 (rank : 166)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	109
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

APBA3_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.155339 (rank : 171)
Query Neighborhood Hits	266	Target Neighborhood Hits	174	Shared Neighborhood Hits	105
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARHG4_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.052302 (rank : 227)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.050466 (rank : 233)
Query Neighborhood Hits	266	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.052211 (rank : 228)
Query Neighborhood Hits	266	Target Neighborhood Hits	235	Shared Neighborhood Hits	21
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.052403 (rank : 225)
Query Neighborhood Hits	266	Target Neighborhood Hits	234	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ECT2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.056690 (rank : 222)
Query Neighborhood Hits	266	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.055083 (rank : 224)
Query Neighborhood Hits	266	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EM55_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.134104 (rank : 181)
Query Neighborhood Hits	266	Target Neighborhood Hits	228	Shared Neighborhood Hits	98
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.133629 (rank : 183)
Query Neighborhood Hits	266	Target Neighborhood Hits	221	Shared Neighborhood Hits	95
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

GIPC1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.075495 (rank : 210)
Query Neighborhood Hits	266	Target Neighborhood Hits	91	Shared Neighborhood Hits	61
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.081063 (rank : 207)
Query Neighborhood Hits	266	Target Neighborhood Hits	92	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.064794 (rank : 219)
Query Neighborhood Hits	266	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GP155_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.063281 (rank : 220)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

HTRA1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.052316 (rank : 226)
Query Neighborhood Hits	266	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.051050 (rank : 231)
Query Neighborhood Hits	266	Target Neighborhood Hits	140	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

KGUA_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.070706 (rank : 215)
Query Neighborhood Hits	266	Target Neighborhood Hits	41	Shared Neighborhood Hits	15
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.072073 (rank : 213)
Query Neighborhood Hits	266	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

MPP2_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.104787 (rank : 192)
Query Neighborhood Hits	266	Target Neighborhood Hits	173	Shared Neighborhood Hits	73
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.108033 (rank : 189)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP3_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.158089 (rank : 169)
Query Neighborhood Hits	266	Target Neighborhood Hits	171	Shared Neighborhood Hits	105
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

MPP3_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.158521 (rank : 168)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	105
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP4_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.174533 (rank : 155)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.152249 (rank : 172)
Query Neighborhood Hits	266	Target Neighborhood Hits	188	Shared Neighborhood Hits	97
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

MPP5_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.170528 (rank : 157)
Query Neighborhood Hits	266	Target Neighborhood Hits	231	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.170118 (rank : 159)
Query Neighborhood Hits	266	Target Neighborhood Hits	226	Shared Neighborhood Hits	107
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP6_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.104135 (rank : 193)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.106252 (rank : 191)
Query Neighborhood Hits	266	Target Neighborhood Hits	187	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.050884 (rank : 232)
Query Neighborhood Hits	266	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOS1_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.116748 (rank : 186)
Query Neighborhood Hits	266	Target Neighborhood Hits	155	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PCLO_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.083674 (rank : 204)
Query Neighborhood Hits	266	Target Neighborhood Hits	2275	Shared Neighborhood Hits	132
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI5_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.155442 (rank : 170)
Query Neighborhood Hits	266	Target Neighborhood Hits	322	Shared Neighborhood Hits	109
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.151982 (rank : 173)
Query Neighborhood Hits	266	Target Neighborhood Hits	287	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDZD6_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.063209 (rank : 221)
Query Neighborhood Hits	266	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZD8_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.066641 (rank : 218)
Query Neighborhood Hits	266	Target Neighborhood Hits	185	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PICK1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.170273 (rank : 158)
Query Neighborhood Hits	266	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.168454 (rank : 161)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	100
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RGS12_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.149280 (rank : 176)
Query Neighborhood Hits	266	Target Neighborhood Hits	333	Shared Neighborhood Hits	122
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RHPN2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.073646 (rank : 212)
Query Neighborhood Hits	266	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

RIMS1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.101745 (rank : 197)
Query Neighborhood Hits	266	Target Neighborhood Hits	437	Shared Neighborhood Hits	108
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RIMS2_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.081282 (rank : 206)
Query Neighborhood Hits	266	Target Neighborhood Hits	342	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.079864 (rank : 208)
Query Neighborhood Hits	266	Target Neighborhood Hits	376	Shared Neighborhood Hits	89
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

SH2D3_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.051297 (rank : 230)
Query Neighborhood Hits	266	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.055155 (rank : 223)
Query Neighborhood Hits	266	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

STXB4_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.163028 (rank : 165)
Query Neighborhood Hits	266	Target Neighborhood Hits	616	Shared Neighborhood Hits	101
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.160398 (rank : 167)
Query Neighborhood Hits	266	Target Neighborhood Hits	629	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

Hits sorted by NC score

RPGF6_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	266	Target Neighborhood Hits	266	Shared Neighborhood Hits	266
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF2_HUMAN
NC score	0.973553 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF5_HUMAN
NC score	0.710408 (rank : 3)	θ value	4.41421e-39 (rank : 6)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_MOUSE
NC score	0.700217 (rank : 4)	θ value	1.51715e-39 (rank : 5)
Query Neighborhood Hits	266	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.677334 (rank : 5)	θ value	4.71619e-41 (rank : 3)
Query Neighborhood Hits	266	Target Neighborhood Hits	88	Shared Neighborhood Hits	41
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.676347 (rank : 6)	θ value	1.3722e-40 (rank : 4)
Query Neighborhood Hits	266	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.662897 (rank : 7)	θ value	5.0505e-35 (rank : 7)
Query Neighborhood Hits	266	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.649147 (rank : 8)	θ value	9.52487e-34 (rank : 8)
Query Neighborhood Hits	266	Target Neighborhood Hits	54	Shared Neighborhood Hits	30
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF1_HUMAN
NC score	0.638471 (rank : 9)	θ value	1.2077e-20 (rank : 9)
Query Neighborhood Hits	266	Target Neighborhood Hits	262	Shared Neighborhood Hits	28
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

PDZD7_HUMAN
NC score	0.518237 (rank : 10)	θ value	6.00763e-12 (rank : 22)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	155
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

RGL1_HUMAN
NC score	0.512163 (rank : 11)	θ value	1.09485e-13 (rank : 17)
Query Neighborhood Hits	266	Target Neighborhood Hits	43	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

WHRN_HUMAN
NC score	0.509514 (rank : 12)	θ value	7.58209e-15 (rank : 16)
Query Neighborhood Hits	266	Target Neighborhood Hits	325	Shared Neighborhood Hits	169
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
NC score	0.504695 (rank : 13)	θ value	3.40345e-15 (rank : 15)
Query Neighborhood Hits	266	Target Neighborhood Hits	412	Shared Neighborhood Hits	172
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PDZ11_HUMAN
NC score	0.502719 (rank : 14)	θ value	4.0297e-08 (rank : 28)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	139
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
NC score	0.502555 (rank : 15)	θ value	1.80886e-08 (rank : 26)
Query Neighborhood Hits	266	Target Neighborhood Hits	154	Shared Neighborhood Hits	136
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

SOS2_HUMAN
NC score	0.498918 (rank : 16)	θ value	3.40345e-15 (rank : 14)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	34
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

RGL1_MOUSE
NC score	0.494152 (rank : 17)	θ value	1.42992e-13 (rank : 18)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.489468 (rank : 18)	θ value	5.43371e-13 (rank : 20)
Query Neighborhood Hits	266	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNRP_HUMAN
NC score	0.485388 (rank : 19)	θ value	1.63225e-17 (rank : 11)
Query Neighborhood Hits	266	Target Neighborhood Hits	239	Shared Neighborhood Hits	29
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

RGL2_MOUSE
NC score	0.484946 (rank : 20)	θ value	2.52405e-10 (rank : 23)
Query Neighborhood Hits	266	Target Neighborhood Hits	51	Shared Neighborhood Hits	23
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

SOS1_MOUSE
NC score	0.482520 (rank : 21)	θ value	1.80466e-16 (rank : 13)
Query Neighborhood Hits	266	Target Neighborhood Hits	281	Shared Neighborhood Hits	29
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GNDS_HUMAN
NC score	0.482446 (rank : 22)	θ value	2.43908e-13 (rank : 19)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	32
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

SOS1_HUMAN
NC score	0.481745 (rank : 23)	θ value	1.80466e-16 (rank : 12)
Query Neighborhood Hits	266	Target Neighborhood Hits	274	Shared Neighborhood Hits	30
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

RGL2_HUMAN
NC score	0.481740 (rank : 24)	θ value	1.63604e-09 (rank : 24)
Query Neighborhood Hits	266	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

USH1C_HUMAN
NC score	0.477108 (rank : 25)	θ value	8.11959e-09 (rank : 25)
Query Neighborhood Hits	266	Target Neighborhood Hits	327	Shared Neighborhood Hits	171
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

GNRP_MOUSE
NC score	0.474947 (rank : 26)	θ value	7.32683e-18 (rank : 10)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SYJ2B_HUMAN
NC score	0.455620 (rank : 27)	θ value	1.43324e-05 (rank : 38)
Query Neighborhood Hits	266	Target Neighborhood Hits	162	Shared Neighborhood Hits	142
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

GRP3_HUMAN
NC score	0.454885 (rank : 28)	θ value	5.43371e-13 (rank : 21)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

LIN7B_HUMAN
NC score	0.446271 (rank : 29)	θ value	2.21117e-06 (rank : 31)
Query Neighborhood Hits	266	Target Neighborhood Hits	200	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

USH1C_MOUSE
NC score	0.444829 (rank : 30)	θ value	3.08544e-08 (rank : 27)
Query Neighborhood Hits	266	Target Neighborhood Hits	557	Shared Neighborhood Hits	172
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

LIN7B_MOUSE
NC score	0.444281 (rank : 31)	θ value	1.29631e-06 (rank : 29)
Query Neighborhood Hits	266	Target Neighborhood Hits	200	Shared Neighborhood Hits	155
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7A_MOUSE
NC score	0.443306 (rank : 32)	θ value	1.09739e-05 (rank : 37)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	152
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.443179 (rank : 33)	θ value	1.09739e-05 (rank : 36)
Query Neighborhood Hits	266	Target Neighborhood Hits	193	Shared Neighborhood Hits	152
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7C_HUMAN
NC score	0.442632 (rank : 34)	θ value	2.21117e-06 (rank : 32)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.442632 (rank : 35)	θ value	2.21117e-06 (rank : 33)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	153
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

RGDSR_HUMAN
NC score	0.425920 (rank : 36)	θ value	1.69304e-06 (rank : 30)
Query Neighborhood Hits	266	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

NHERF_MOUSE
NC score	0.414360 (rank : 37)	θ value	4.1701e-05 (rank : 41)
Query Neighborhood Hits	266	Target Neighborhood Hits	195	Shared Neighborhood Hits	150
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_HUMAN
NC score	0.408312 (rank : 38)	θ value	0.000158464 (rank : 49)
Query Neighborhood Hits	266	Target Neighborhood Hits	190	Shared Neighborhood Hits	150
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
NC score	0.403789 (rank : 39)	θ value	7.1131e-05 (rank : 45)
Query Neighborhood Hits	266	Target Neighborhood Hits	197	Shared Neighborhood Hits	157
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.399086 (rank : 40)	θ value	0.00020696 (rank : 51)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZD1_HUMAN
NC score	0.389979 (rank : 41)	θ value	0.00390308 (rank : 79)
Query Neighborhood Hits	266	Target Neighborhood Hits	190	Shared Neighborhood Hits	152
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
NC score	0.387319 (rank : 42)	θ value	0.00175202 (rank : 73)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	148
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MPDZ_MOUSE
NC score	0.381691 (rank : 43)	θ value	0.000158464 (rank : 48)
Query Neighborhood Hits	266	Target Neighborhood Hits	298	Shared Neighborhood Hits	162
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

TX1B3_HUMAN
NC score	0.380979 (rank : 44)	θ value	0.279714 (rank : 151)
Query Neighborhood Hits	266	Target Neighborhood Hits	161	Shared Neighborhood Hits	146
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.380866 (rank : 45)	θ value	0.279714 (rank : 152)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	144
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

INADL_MOUSE
NC score	0.377991 (rank : 46)	θ value	0.00869519 (rank : 88)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	161
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_HUMAN
NC score	0.375936 (rank : 47)	θ value	0.00035302 (rank : 53)
Query Neighborhood Hits	266	Target Neighborhood Hits	261	Shared Neighborhood Hits	161
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

INADL_HUMAN
NC score	0.374660 (rank : 48)	θ value	0.00134147 (rank : 69)
Query Neighborhood Hits	266	Target Neighborhood Hits	260	Shared Neighborhood Hits	156
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

ZO3_MOUSE
NC score	0.370475 (rank : 49)	θ value	6.43352e-06 (rank : 34)
Query Neighborhood Hits	266	Target Neighborhood Hits	224	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GOPC_MOUSE
NC score	0.367244 (rank : 50)	θ value	0.000786445 (rank : 66)
Query Neighborhood Hits	266	Target Neighborhood Hits	323	Shared Neighborhood Hits	142
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

ZO3_HUMAN
NC score	0.361822 (rank : 51)	θ value	1.87187e-05 (rank : 39)
Query Neighborhood Hits	266	Target Neighborhood Hits	219	Shared Neighborhood Hits	145
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

GOPC_HUMAN
NC score	0.361803 (rank : 52)	θ value	0.000786445 (rank : 65)
Query Neighborhood Hits	266	Target Neighborhood Hits	377	Shared Neighborhood Hits	143
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

PDZD2_HUMAN
NC score	0.361471 (rank : 53)	θ value	4.1701e-05 (rank : 42)
Query Neighborhood Hits	266	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

MAGI1_HUMAN
NC score	0.359120 (rank : 54)	θ value	0.00035302 (rank : 52)
Query Neighborhood Hits	266	Target Neighborhood Hits	388	Shared Neighborhood Hits	165
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.351231 (rank : 55)	θ value	0.00298849 (rank : 77)
Query Neighborhood Hits	266	Target Neighborhood Hits	403	Shared Neighborhood Hits	161
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

DLG4_MOUSE
NC score	0.348003 (rank : 56)	θ value	0.000786445 (rank : 64)
Query Neighborhood Hits	266	Target Neighborhood Hits	282	Shared Neighborhood Hits	152
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.347284 (rank : 57)	θ value	0.000786445 (rank : 63)
Query Neighborhood Hits	266	Target Neighborhood Hits	286	Shared Neighborhood Hits	152
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG3_MOUSE
NC score	0.344494 (rank : 58)	θ value	7.1131e-05 (rank : 44)
Query Neighborhood Hits	266	Target Neighborhood Hits	274	Shared Neighborhood Hits	147
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG3_HUMAN
NC score	0.344341 (rank : 59)	θ value	7.1131e-05 (rank : 43)
Query Neighborhood Hits	266	Target Neighborhood Hits	269	Shared Neighborhood Hits	147
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

PDZD3_HUMAN
NC score	0.342258 (rank : 60)	θ value	0.365318 (rank : 155)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	142
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SNTG2_HUMAN
NC score	0.340582 (rank : 61)	θ value	0.0252991 (rank : 109)
Query Neighborhood Hits	266	Target Neighborhood Hits	191	Shared Neighborhood Hits	150
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

DLG2_MOUSE
NC score	0.336975 (rank : 62)	θ value	0.000786445 (rank : 62)
Query Neighborhood Hits	266	Target Neighborhood Hits	271	Shared Neighborhood Hits	143
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MAGI2_HUMAN
NC score	0.336970 (rank : 63)	θ value	0.00869519 (rank : 89)
Query Neighborhood Hits	266	Target Neighborhood Hits	373	Shared Neighborhood Hits	155
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

DLG2_HUMAN
NC score	0.336610 (rank : 64)	θ value	0.000602161 (rank : 56)
Query Neighborhood Hits	266	Target Neighborhood Hits	279	Shared Neighborhood Hits	145
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PARD3_MOUSE
NC score	0.336584 (rank : 65)	θ value	0.0736092 (rank : 126)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	140
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

MAGI2_MOUSE
NC score	0.335325 (rank : 66)	θ value	0.00869519 (rank : 90)
Query Neighborhood Hits	266	Target Neighborhood Hits	370	Shared Neighborhood Hits	154
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PARD3_HUMAN
NC score	0.334780 (rank : 67)	θ value	0.0252991 (rank : 107)
Query Neighborhood Hits	266	Target Neighborhood Hits	312	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

ZO2_MOUSE
NC score	0.331441 (rank : 68)	θ value	0.000602161 (rank : 61)
Query Neighborhood Hits	266	Target Neighborhood Hits	296	Shared Neighborhood Hits	146
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

PAR3L_HUMAN
NC score	0.331083 (rank : 69)	θ value	0.62314 (rank : 165)
Query Neighborhood Hits	266	Target Neighborhood Hits	297	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

ZO2_HUMAN
NC score	0.330562 (rank : 70)	θ value	0.000602161 (rank : 60)
Query Neighborhood Hits	266	Target Neighborhood Hits	289	Shared Neighborhood Hits	146
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

LNX2_MOUSE
NC score	0.330448 (rank : 71)	θ value	0.0330416 (rank : 117)
Query Neighborhood Hits	266	Target Neighborhood Hits	407	Shared Neighborhood Hits	149
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

PDZD3_MOUSE
NC score	0.330418 (rank : 72)	θ value	1.06291 (rank : 178)
Query Neighborhood Hits	266	Target Neighborhood Hits	171	Shared Neighborhood Hits	141
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

DLG1_HUMAN
NC score	0.329151 (rank : 73)	θ value	0.0330416 (rank : 111)
Query Neighborhood Hits	266	Target Neighborhood Hits	290	Shared Neighborhood Hits	144
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

ZO1_MOUSE
NC score	0.326954 (rank : 74)	θ value	0.000786445 (rank : 68)
Query Neighborhood Hits	266	Target Neighborhood Hits	453	Shared Neighborhood Hits	154
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

DLG1_MOUSE
NC score	0.326601 (rank : 75)	θ value	0.0330416 (rank : 112)
Query Neighborhood Hits	266	Target Neighborhood Hits	285	Shared Neighborhood Hits	143
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

SNTG2_MOUSE
NC score	0.325635 (rank : 76)	θ value	0.0252991 (rank : 110)
Query Neighborhood Hits	266	Target Neighborhood Hits	176	Shared Neighborhood Hits	143
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

IL16_HUMAN
NC score	0.324809 (rank : 77)	θ value	0.125558 (rank : 135)
Query Neighborhood Hits	266	Target Neighborhood Hits	207	Shared Neighborhood Hits	123
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LNX2_HUMAN
NC score	0.324373 (rank : 78)	θ value	0.0330416 (rank : 116)
Query Neighborhood Hits	266	Target Neighborhood Hits	389	Shared Neighborhood Hits	149
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

ZO1_HUMAN
NC score	0.322153 (rank : 79)	θ value	0.000786445 (rank : 67)
Query Neighborhood Hits	266	Target Neighborhood Hits	474	Shared Neighborhood Hits	149
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

IL16_MOUSE
NC score	0.316991 (rank : 80)	θ value	0.0330416 (rank : 113)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	119
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

SNTG1_HUMAN
NC score	0.314709 (rank : 81)	θ value	0.279714 (rank : 150)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	142
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
NC score	0.314591 (rank : 82)	θ value	0.365318 (rank : 156)
Query Neighborhood Hits	266	Target Neighborhood Hits	179	Shared Neighborhood Hits	142
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

GRIP2_HUMAN
NC score	0.310798 (rank : 83)	θ value	1.81305 (rank : 190)
Query Neighborhood Hits	266	Target Neighborhood Hits	256	Shared Neighborhood Hits	158
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRIP1_MOUSE
NC score	0.308035 (rank : 84)	θ value	3.0926 (rank : 209)
Query Neighborhood Hits	266	Target Neighborhood Hits	241	Shared Neighborhood Hits	157
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

SNTB2_MOUSE
NC score	0.307531 (rank : 85)	θ value	0.0736092 (rank : 129)
Query Neighborhood Hits	266	Target Neighborhood Hits	181	Shared Neighborhood Hits	133
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_HUMAN
NC score	0.307369 (rank : 86)	θ value	0.0736092 (rank : 128)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	133
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

GRIP1_HUMAN
NC score	0.307267 (rank : 87)	θ value	5.27518 (rank : 227)
Query Neighborhood Hits	266	Target Neighborhood Hits	231	Shared Neighborhood Hits	156
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

LNX1_MOUSE
NC score	0.306081 (rank : 88)	θ value	0.365318 (rank : 154)
Query Neighborhood Hits	266	Target Neighborhood Hits	377	Shared Neighborhood Hits	145
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

K1849_MOUSE
NC score	0.303741 (rank : 89)	θ value	1.09739e-05 (rank : 35)
Query Neighborhood Hits	266	Target Neighborhood Hits	335	Shared Neighborhood Hits	131
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

SNTA1_HUMAN
NC score	0.301966 (rank : 90)	θ value	0.21417 (rank : 144)
Query Neighborhood Hits	266	Target Neighborhood Hits	186	Shared Neighborhood Hits	135
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

K1849_HUMAN
NC score	0.298878 (rank : 91)	θ value	0.000121331 (rank : 46)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PZRN4_HUMAN
NC score	0.298770 (rank : 92)	θ value	0.0193708 (rank : 102)
Query Neighborhood Hits	266	Target Neighborhood Hits	438	Shared Neighborhood Hits	130
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_MOUSE
NC score	0.297388 (rank : 93)	θ value	0.47712 (rank : 162)
Query Neighborhood Hits	266	Target Neighborhood Hits	447	Shared Neighborhood Hits	136
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

LNX1_HUMAN
NC score	0.295655 (rank : 94)	θ value	2.36792 (rank : 203)
Query Neighborhood Hits	266	Target Neighborhood Hits	379	Shared Neighborhood Hits	137
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

PZRN3_HUMAN
NC score	0.295543 (rank : 95)	θ value	0.47712 (rank : 161)
Query Neighborhood Hits	266	Target Neighborhood Hits	461	Shared Neighborhood Hits	133
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SNTA1_MOUSE
NC score	0.290879 (rank : 96)	θ value	0.62314 (rank : 166)
Query Neighborhood Hits	266	Target Neighborhood Hits	170	Shared Neighborhood Hits	131
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

PDLI2_MOUSE
NC score	0.278663 (rank : 97)	θ value	0.47712 (rank : 159)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	119
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

SYP2L_HUMAN
NC score	0.278329 (rank : 98)	θ value	0.00228821 (rank : 74)
Query Neighborhood Hits	266	Target Neighborhood Hits	400	Shared Neighborhood Hits	115
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SNTB1_HUMAN
NC score	0.275267 (rank : 99)	θ value	2.36792 (rank : 206)
Query Neighborhood Hits	266	Target Neighborhood Hits	157	Shared Neighborhood Hits	123
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
NC score	0.273451 (rank : 100)	θ value	4.03905 (rank : 222)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

PDLI2_HUMAN
NC score	0.272691 (rank : 101)	θ value	0.813845 (rank : 172)
Query Neighborhood Hits	266	Target Neighborhood Hits	245	Shared Neighborhood Hits	123
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

SYNP2_MOUSE
NC score	0.270782 (rank : 102)	θ value	0.00134147 (rank : 71)
Query Neighborhood Hits	266	Target Neighborhood Hits	252	Shared Neighborhood Hits	114
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SDCB1_MOUSE
NC score	0.266361 (rank : 103)	θ value	0.0193708 (rank : 105)
Query Neighborhood Hits	266	Target Neighborhood Hits	144	Shared Neighborhood Hits	115
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SDCB1_HUMAN
NC score	0.265020 (rank : 104)	θ value	0.0193708 (rank : 104)
Query Neighborhood Hits	266	Target Neighborhood Hits	150	Shared Neighborhood Hits	121
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

LAP4_HUMAN
NC score	0.261461 (rank : 105)	θ value	0.00020696 (rank : 50)
Query Neighborhood Hits	266	Target Neighborhood Hits	608	Shared Neighborhood Hits	163
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

AFAD_HUMAN
NC score	0.260655 (rank : 106)	θ value	0.0736092 (rank : 124)
Query Neighborhood Hits	266	Target Neighborhood Hits	689	Shared Neighborhood Hits	134
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

PDZK4_MOUSE
NC score	0.259985 (rank : 107)	θ value	0.00665767 (rank : 86)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	111
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

GRASP_HUMAN
NC score	0.258491 (rank : 108)	θ value	2.36792 (rank : 200)
Query Neighborhood Hits	266	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

PDZK4_HUMAN
NC score	0.256388 (rank : 109)	θ value	0.00509761 (rank : 83)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	107
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LAP4_MOUSE
NC score	0.255194 (rank : 110)	θ value	0.00134147 (rank : 70)
Query Neighborhood Hits	266	Target Neighborhood Hits	590	Shared Neighborhood Hits	161
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

GRASP_MOUSE
NC score	0.255159 (rank : 111)	θ value	2.36792 (rank : 201)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	112
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

DVL1_HUMAN
NC score	0.254459 (rank : 112)	θ value	0.0431538 (rank : 119)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	99
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_HUMAN
NC score	0.253615 (rank : 113)	θ value	0.0193708 (rank : 100)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	94
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_MOUSE
NC score	0.253535 (rank : 114)	θ value	0.0431538 (rank : 120)
Query Neighborhood Hits	266	Target Neighborhood Hits	146	Shared Neighborhood Hits	97
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_MOUSE
NC score	0.253133 (rank : 115)	θ value	0.0193708 (rank : 101)
Query Neighborhood Hits	266	Target Neighborhood Hits	198	Shared Neighborhood Hits	94
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PAR6B_HUMAN
NC score	0.252517 (rank : 116)	θ value	0.00869519 (rank : 91)
Query Neighborhood Hits	266	Target Neighborhood Hits	126	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

DVL2_MOUSE
NC score	0.251924 (rank : 117)	θ value	0.00509761 (rank : 81)
Query Neighborhood Hits	266	Target Neighborhood Hits	233	Shared Neighborhood Hits	97
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_HUMAN
NC score	0.251775 (rank : 118)	θ value	0.00509761 (rank : 80)
Query Neighborhood Hits	266	Target Neighborhood Hits	223	Shared Neighborhood Hits	99
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

PAR6B_MOUSE
NC score	0.251430 (rank : 119)	θ value	0.0148317 (rank : 97)
Query Neighborhood Hits	266	Target Neighborhood Hits	128	Shared Neighborhood Hits	97
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_HUMAN
NC score	0.251370 (rank : 120)	θ value	0.00665767 (rank : 84)
Query Neighborhood Hits	266	Target Neighborhood Hits	159	Shared Neighborhood Hits	92
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6G_MOUSE
NC score	0.249861 (rank : 121)	θ value	0.00665767 (rank : 85)
Query Neighborhood Hits	266	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

ARHGB_HUMAN
NC score	0.248433 (rank : 122)	θ value	0.000158464 (rank : 47)
Query Neighborhood Hits	266	Target Neighborhood Hits	375	Shared Neighborhood Hits	150
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

DVL1L_HUMAN
NC score	0.247986 (rank : 123)	θ value	0.0431538 (rank : 118)
Query Neighborhood Hits	266	Target Neighborhood Hits	146	Shared Neighborhood Hits	98
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DLG5_HUMAN
NC score	0.247284 (rank : 124)	θ value	0.000602161 (rank : 57)
Query Neighborhood Hits	266	Target Neighborhood Hits	1088	Shared Neighborhood Hits	159
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

RHPN1_MOUSE
NC score	0.247077 (rank : 125)	θ value	0.0193708 (rank : 103)
Query Neighborhood Hits	266	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_HUMAN
NC score	0.246221 (rank : 126)	θ value	0.00298849 (rank : 78)
Query Neighborhood Hits	266	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SYNP2_HUMAN
NC score	0.240195 (rank : 127)	θ value	0.00665767 (rank : 87)
Query Neighborhood Hits	266	Target Neighborhood Hits	323	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

PTN13_HUMAN
NC score	0.234078 (rank : 128)	θ value	2.44474e-05 (rank : 40)
Query Neighborhood Hits	266	Target Neighborhood Hits	471	Shared Neighborhood Hits	157
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

PDLI4_MOUSE
NC score	0.233372 (rank : 129)	θ value	0.0148317 (rank : 99)
Query Neighborhood Hits	266	Target Neighborhood Hits	233	Shared Neighborhood Hits	107
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI1_HUMAN
NC score	0.230075 (rank : 130)	θ value	0.00869519 (rank : 92)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	100
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI4_HUMAN
NC score	0.230020 (rank : 131)	θ value	0.0148317 (rank : 98)
Query Neighborhood Hits	266	Target Neighborhood Hits	245	Shared Neighborhood Hits	105
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PAR6A_MOUSE
NC score	0.227801 (rank : 132)	θ value	0.163984 (rank : 141)
Query Neighborhood Hits	266	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PTN13_MOUSE
NC score	0.227538 (rank : 133)	θ value	0.00035302 (rank : 54)
Query Neighborhood Hits	266	Target Neighborhood Hits	426	Shared Neighborhood Hits	155
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PAR6A_HUMAN
NC score	0.227067 (rank : 134)	θ value	0.163984 (rank : 140)
Query Neighborhood Hits	266	Target Neighborhood Hits	119	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PSCBP_MOUSE
NC score	0.226415 (rank : 135)	θ value	1.81305 (rank : 195)
Query Neighborhood Hits	266	Target Neighborhood Hits	118	Shared Neighborhood Hits	108
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SYP2L_MOUSE
NC score	0.221325 (rank : 136)	θ value	1.06291 (rank : 179)
Query Neighborhood Hits	266	Target Neighborhood Hits	289	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PSCBP_HUMAN
NC score	0.220176 (rank : 137)	θ value	0.279714 (rank : 148)
Query Neighborhood Hits	266	Target Neighborhood Hits	123	Shared Neighborhood Hits	105
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

PDLI3_HUMAN
NC score	0.219473 (rank : 138)	θ value	0.0736092 (rank : 127)
Query Neighborhood Hits	266	Target Neighborhood Hits	199	Shared Neighborhood Hits	105
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SHAN2_HUMAN
NC score	0.218069 (rank : 139)	θ value	0.0431538 (rank : 122)
Query Neighborhood Hits	266	Target Neighborhood Hits	346	Shared Neighborhood Hits	115
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

PDLI1_MOUSE
NC score	0.215426 (rank : 140)	θ value	0.163984 (rank : 142)
Query Neighborhood Hits	266	Target Neighborhood Hits	213	Shared Neighborhood Hits	97
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

CT152_HUMAN
NC score	0.214281 (rank : 141)	θ value	0.000602161 (rank : 55)
Query Neighborhood Hits	266	Target Neighborhood Hits	30	Shared Neighborhood Hits	15
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

SDCB2_MOUSE
NC score	0.212246 (rank : 142)	θ value	0.813845 (rank : 173)
Query Neighborhood Hits	266	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI3_MOUSE
NC score	0.210864 (rank : 143)	θ value	0.21417 (rank : 143)
Query Neighborhood Hits	266	Target Neighborhood Hits	197	Shared Neighborhood Hits	100
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

ARHGC_MOUSE
NC score	0.210608 (rank : 144)	θ value	0.00298849 (rank : 76)
Query Neighborhood Hits	266	Target Neighborhood Hits	344	Shared Neighborhood Hits	138
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_HUMAN
NC score	0.210367 (rank : 145)	θ value	0.00298849 (rank : 75)
Query Neighborhood Hits	266	Target Neighborhood Hits	351	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

SDCB2_HUMAN
NC score	0.205992 (rank : 146)	θ value	0.279714 (rank : 149)
Query Neighborhood Hits	266	Target Neighborhood Hits	121	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

NEB1_HUMAN
NC score	0.203757 (rank : 147)	θ value	0.813845 (rank : 171)
Query Neighborhood Hits	266	Target Neighborhood Hits	829	Shared Neighborhood Hits	115
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

SHAN2_MOUSE
NC score	0.198702 (rank : 148)	θ value	0.0563607 (rank : 123)
Query Neighborhood Hits	266	Target Neighborhood Hits	446	Shared Neighborhood Hits	113
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

APXL_HUMAN
NC score	0.185466 (rank : 149)	θ value	2.36792 (rank : 197)
Query Neighborhood Hits	266	Target Neighborhood Hits	553	Shared Neighborhood Hits	91
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

NEB2_HUMAN
NC score	0.180050 (rank : 150)	θ value	5.27518 (rank : 232)
Query Neighborhood Hits	266	Target Neighborhood Hits	883	Shared Neighborhood Hits	110
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

LDB3_MOUSE
NC score	0.179893 (rank : 151)	θ value	0.000602161 (rank : 59)
Query Neighborhood Hits	266	Target Neighborhood Hits	510	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LDB3_HUMAN
NC score	0.178563 (rank : 152)	θ value	0.000602161 (rank : 58)
Query Neighborhood Hits	266	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

NEB2_MOUSE
NC score	0.177826 (rank : 153)	θ value	5.27518 (rank : 233)
Query Neighborhood Hits	266	Target Neighborhood Hits	889	Shared Neighborhood Hits	111
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

PDLI7_HUMAN
NC score	0.175612 (rank : 154)	θ value	0.00175202 (rank : 72)
Query Neighborhood Hits	266	Target Neighborhood Hits	547	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

MPP4_HUMAN
NC score	0.174533 (rank : 155)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

CT152_MOUSE
NC score	0.174437 (rank : 156)	θ value	0.0148317 (rank : 95)
Query Neighborhood Hits	266	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

MPP5_HUMAN
NC score	0.170528 (rank : 157)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	266	Target Neighborhood Hits	231	Shared Neighborhood Hits	107
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

PICK1_HUMAN
NC score	0.170273 (rank : 158)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	266	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

MPP5_MOUSE
NC score	0.170118 (rank : 159)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	266	Target Neighborhood Hits	226	Shared Neighborhood Hits	107
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PDLI7_MOUSE
NC score	0.168599 (rank : 160)	θ value	0.00509761 (rank : 82)
Query Neighborhood Hits	266	Target Neighborhood Hits	279	Shared Neighborhood Hits	98
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PICK1_MOUSE
NC score	0.168454 (rank : 161)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	100
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

APBA1_HUMAN
NC score	0.168373 (rank : 162)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	266	Target Neighborhood Hits	325	Shared Neighborhood Hits	125
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
NC score	0.166760 (rank : 163)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	266	Target Neighborhood Hits	220	Shared Neighborhood Hits	122
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
NC score	0.165399 (rank : 164)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	266	Target Neighborhood Hits	219	Shared Neighborhood Hits	121
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

STXB4_HUMAN
NC score	0.163028 (rank : 165)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	266	Target Neighborhood Hits	616	Shared Neighborhood Hits	101
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBA3_HUMAN
NC score	0.161287 (rank : 166)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	109
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

STXB4_MOUSE
NC score	0.160398 (rank : 167)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	266	Target Neighborhood Hits	629	Shared Neighborhood Hits	94
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MPP3_MOUSE
NC score	0.158521 (rank : 168)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	266	Target Neighborhood Hits	165	Shared Neighborhood Hits	105
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

MPP3_HUMAN
NC score	0.158089 (rank : 169)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	266	Target Neighborhood Hits	171	Shared Neighborhood Hits	105
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

PDLI5_HUMAN
NC score	0.155442 (rank : 170)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	266	Target Neighborhood Hits	322	Shared Neighborhood Hits	109
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

APBA3_MOUSE
NC score	0.155339 (rank : 171)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	266	Target Neighborhood Hits	174	Shared Neighborhood Hits	105
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MPP4_MOUSE
NC score	0.152249 (rank : 172)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	266	Target Neighborhood Hits	188	Shared Neighborhood Hits	97
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PDLI5_MOUSE
NC score	0.151982 (rank : 173)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	266	Target Neighborhood Hits	287	Shared Neighborhood Hits	106
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

LRRC7_HUMAN
NC score	0.150813 (rank : 174)	θ value	0.0961366 (rank : 130)
Query Neighborhood Hits	266	Target Neighborhood Hits	423	Shared Neighborhood Hits	117
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
NC score	0.150013 (rank : 175)	θ value	0.0961366 (rank : 131)
Query Neighborhood Hits	266	Target Neighborhood Hits	416	Shared Neighborhood Hits	113
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RGS12_HUMAN
NC score	0.149280 (rank : 176)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	266	Target Neighborhood Hits	333	Shared Neighborhood Hits	122
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

NOS1_HUMAN
NC score	0.148877 (rank : 177)	θ value	1.81305 (rank : 193)
Query Neighborhood Hits	266	Target Neighborhood Hits	218	Shared Neighborhood Hits	117
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

LAP2_HUMAN
NC score	0.142153 (rank : 178)	θ value	0.0330416 (rank : 114)
Query Neighborhood Hits	266	Target Neighborhood Hits	499	Shared Neighborhood Hits	102
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

PREX1_HUMAN
NC score	0.140173 (rank : 179)	θ value	1.38821 (rank : 182)
Query Neighborhood Hits	266	Target Neighborhood Hits	177	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

LAP2_MOUSE
NC score	0.136666 (rank : 180)	θ value	0.0330416 (rank : 115)
Query Neighborhood Hits	266	Target Neighborhood Hits	482	Shared Neighborhood Hits	102
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

EM55_HUMAN
NC score	0.134104 (rank : 181)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	266	Target Neighborhood Hits	228	Shared Neighborhood Hits	98
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

SHAN1_HUMAN
NC score	0.134014 (rank : 182)	θ value	0.0252991 (rank : 108)
Query Neighborhood Hits	266	Target Neighborhood Hits	1041	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EM55_MOUSE
NC score	0.133629 (rank : 183)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	266	Target Neighborhood Hits	221	Shared Neighborhood Hits	95
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

KAP1_HUMAN
NC score	0.124924 (rank : 184)	θ value	0.0148317 (rank : 96)
Query Neighborhood Hits	266	Target Neighborhood Hits	58	Shared Neighborhood Hits	19
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.120340 (rank : 185)	θ value	0.0736092 (rank : 125)
Query Neighborhood Hits	266	Target Neighborhood Hits	49	Shared Neighborhood Hits	16
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

NOS1_MOUSE
NC score	0.116748 (rank : 186)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	266	Target Neighborhood Hits	155	Shared Neighborhood Hits	94
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

KAP2_MOUSE
NC score	0.111486 (rank : 187)	θ value	0.125558 (rank : 136)
Query Neighborhood Hits	266	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.108814 (rank : 188)	θ value	0.279714 (rank : 145)
Query Neighborhood Hits	266	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

MPP2_MOUSE
NC score	0.108033 (rank : 189)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

KAP3_HUMAN
NC score	0.107476 (rank : 190)	θ value	0.365318 (rank : 153)
Query Neighborhood Hits	266	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

MPP6_MOUSE
NC score	0.106252 (rank : 191)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	266	Target Neighborhood Hits	187	Shared Neighborhood Hits	76
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MPP2_HUMAN
NC score	0.104787 (rank : 192)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	266	Target Neighborhood Hits	173	Shared Neighborhood Hits	73
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP6_HUMAN
NC score	0.104135 (rank : 193)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	266	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

KAP2_HUMAN
NC score	0.103792 (rank : 194)	θ value	1.06291 (rank : 175)
Query Neighborhood Hits	266	Target Neighborhood Hits	48	Shared Neighborhood Hits	15
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP0_MOUSE
NC score	0.102382 (rank : 195)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	266	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
NC score	0.101864 (rank : 196)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	266	Target Neighborhood Hits	52	Shared Neighborhood Hits	16
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

RIMS1_HUMAN
NC score	0.101745 (rank : 197)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	266	Target Neighborhood Hits	437	Shared Neighborhood Hits	108
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TIAM1_HUMAN
NC score	0.098573 (rank : 198)	θ value	1.81305 (rank : 196)
Query Neighborhood Hits	266	Target Neighborhood Hits	225	Shared Neighborhood Hits	67
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PTN4_HUMAN
NC score	0.096541 (rank : 199)	θ value	0.47712 (rank : 160)
Query Neighborhood Hits	266	Target Neighborhood Hits	303	Shared Neighborhood Hits	120
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

PTN3_HUMAN
NC score	0.093359 (rank : 200)	θ value	5.27518 (rank : 236)
Query Neighborhood Hits	266	Target Neighborhood Hits	258	Shared Neighborhood Hits	113
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

HTRA3_MOUSE
NC score	0.093291 (rank : 201)	θ value	0.163984 (rank : 138)
Query Neighborhood Hits	266	Target Neighborhood Hits	156	Shared Neighborhood Hits	69
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

LMO7_HUMAN
NC score	0.086637 (rank : 202)	θ value	4.03905 (rank : 218)
Query Neighborhood Hits	266	Target Neighborhood Hits	507	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

CAR14_MOUSE
NC score	0.084114 (rank : 203)	θ value	0.0252991 (rank : 106)
Query Neighborhood Hits	266	Target Neighborhood Hits	526	Shared Neighborhood Hits	41
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

PCLO_MOUSE
NC score	0.083674 (rank : 204)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	266	Target Neighborhood Hits	2275	Shared Neighborhood Hits	132
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

HTRA3_HUMAN
NC score	0.082533 (rank : 205)	θ value	1.06291 (rank : 174)
Query Neighborhood Hits	266	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

RIMS2_HUMAN
NC score	0.081282 (rank : 206)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	266	Target Neighborhood Hits	342	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

GIPC1_MOUSE
NC score	0.081063 (rank : 207)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	266	Target Neighborhood Hits	92	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

RIMS2_MOUSE
NC score	0.079864 (rank : 208)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	266	Target Neighborhood Hits	376	Shared Neighborhood Hits	89
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

TIAM1_MOUSE
NC score	0.079484 (rank : 209)	θ value	6.88961 (rank : 252)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GIPC1_HUMAN
NC score	0.075495 (rank : 210)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	266	Target Neighborhood Hits	91	Shared Neighborhood Hits	61
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

CAR11_HUMAN
NC score	0.074282 (rank : 211)	θ value	0.813845 (rank : 168)
Query Neighborhood Hits	266	Target Neighborhood Hits	690	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

RHPN2_MOUSE
NC score	0.073646 (rank : 212)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	266	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BWR8, Q9DBN2	Gene names	Rhpn2
Domain Architecture	No domain graphic available
Description	Rhophilin-2 (GTP-Rho-binding protein 2).

KGUA_MOUSE
NC score	0.072073 (rank : 213)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	266	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

CAR14_HUMAN
NC score	0.071998 (rank : 214)	θ value	0.47712 (rank : 157)
Query Neighborhood Hits	266	Target Neighborhood Hits	449	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

KGUA_HUMAN
NC score	0.070706 (rank : 215)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	266	Target Neighborhood Hits	41	Shared Neighborhood Hits	15
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

PSMD9_HUMAN
NC score	0.069679 (rank : 216)	θ value	5.27518 (rank : 235)
Query Neighborhood Hits	266	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O00233, Q9BQ42	Gene names	PSMD9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PSMD9_MOUSE
NC score	0.068513 (rank : 217)	θ value	4.03905 (rank : 221)
Query Neighborhood Hits	266	Target Neighborhood Hits	30	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CR00, Q3TG66	Gene names	Psmd9
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27).

PDZD8_HUMAN
NC score	0.066641 (rank : 218)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	266	Target Neighborhood Hits	185	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

GIPC2_HUMAN
NC score	0.064794 (rank : 219)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	266	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GP155_HUMAN
NC score	0.063281 (rank : 220)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	266	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

PDZD6_HUMAN
NC score	0.063209 (rank : 221)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	266	Target Neighborhood Hits	81	Shared Neighborhood Hits	45
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

ECT2_HUMAN
NC score	0.056690 (rank : 222)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	266	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SH2D3_MOUSE
NC score	0.055155 (rank : 223)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	266	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

ECT2_MOUSE
NC score	0.055083 (rank : 224)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	266	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG9_MOUSE
NC score	0.052403 (rank : 225)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	266	Target Neighborhood Hits	234	Shared Neighborhood Hits	21
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

HTRA1_HUMAN
NC score	0.052316 (rank : 226)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	266	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

ARHG4_HUMAN
NC score	0.052302 (rank : 227)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	266	Target Neighborhood Hits	242	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.052211 (rank : 228)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	266	Target Neighborhood Hits	235	Shared Neighborhood Hits	21
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

MY18A_MOUSE
NC score	0.051655 (rank : 229)	θ value	0.125558 (rank : 137)
Query Neighborhood Hits	266	Target Neighborhood Hits	1989	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SH2D3_HUMAN
NC score	0.051297 (rank : 230)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	266	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

HTRA1_MOUSE
NC score	0.051050 (rank : 231)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	266	Target Neighborhood Hits	140	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

NGEF_HUMAN
NC score	0.050884 (rank : 232)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	266	Target Neighborhood Hits	166	Shared Neighborhood Hits	14
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG4_MOUSE
NC score	0.050466 (rank : 233)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	266	Target Neighborhood Hits	185	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

HTRA4_HUMAN
NC score	0.048137 (rank : 234)	θ value	4.03905 (rank : 216)
Query Neighborhood Hits	266	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

SI1L2_HUMAN
NC score	0.047294 (rank : 235)	θ value	1.38821 (rank : 185)
Query Neighborhood Hits	266	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

MAST4_HUMAN
NC score	0.045275 (rank : 236)	θ value	0.0113563 (rank : 93)
Query Neighborhood Hits	266	Target Neighborhood Hits	1804	Shared Neighborhood Hits	131
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MY18A_HUMAN
NC score	0.044818 (rank : 237)	θ value	1.81305 (rank : 192)
Query Neighborhood Hits	266	Target Neighborhood Hits	1929	Shared Neighborhood Hits	138
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SI1L2_MOUSE
NC score	0.044267 (rank : 238)	θ value	3.0926 (rank : 212)
Query Neighborhood Hits	266	Target Neighborhood Hits	124	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

CEP35_HUMAN
NC score	0.041199 (rank : 239)	θ value	0.125558 (rank : 133)
Query Neighborhood Hits	266	Target Neighborhood Hits	811	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

MAST2_HUMAN
NC score	0.040848 (rank : 240)	θ value	0.279714 (rank : 146)
Query Neighborhood Hits	266	Target Neighborhood Hits	1189	Shared Neighborhood Hits	110
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.040486 (rank : 241)	θ value	0.163984 (rank : 139)
Query Neighborhood Hits	266	Target Neighborhood Hits	1110	Shared Neighborhood Hits	110
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.040424 (rank : 242)	θ value	0.0961366 (rank : 132)
Query Neighborhood Hits	266	Target Neighborhood Hits	1128	Shared Neighborhood Hits	106
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

SIPA1_HUMAN
NC score	0.039251 (rank : 243)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	266	Target Neighborhood Hits	250	Shared Neighborhood Hits	26
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

EPC2_MOUSE
NC score	0.039211 (rank : 244)	θ value	0.125558 (rank : 134)
Query Neighborhood Hits	266	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0I4, Q3URX9, Q80Y70, Q8BXC5	Gene names	Epc2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

SI1L1_HUMAN
NC score	0.038465 (rank : 245)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	266	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.037871 (rank : 246)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	266	Target Neighborhood Hits	189	Shared Neighborhood Hits	40
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

MAST1_MOUSE
NC score	0.037602 (rank : 247)	θ value	2.36792 (rank : 205)
Query Neighborhood Hits	266	Target Neighborhood Hits	1123	Shared Neighborhood Hits	107
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_HUMAN
NC score	0.037166 (rank : 248)	θ value	2.36792 (rank : 204)
Query Neighborhood Hits	266	Target Neighborhood Hits	1146	Shared Neighborhood Hits	109
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

ORC2_HUMAN
NC score	0.035049 (rank : 249)	θ value	0.279714 (rank : 147)
Query Neighborhood Hits	266	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q13416, Q13204	Gene names	ORC2L, ORC2
Domain Architecture
Description	Origin recognition complex subunit 2.

EPC2_HUMAN
NC score	0.034359 (rank : 250)	θ value	0.813845 (rank : 169)
Query Neighborhood Hits	266	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

ANK2_HUMAN
NC score	0.029137 (rank : 251)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	266	Target Neighborhood Hits	1615	Shared Neighborhood Hits	58
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DOK1_HUMAN
NC score	0.028047 (rank : 252)	θ value	0.62314 (rank : 163)
Query Neighborhood Hits	266	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

MDC1_HUMAN
NC score	0.027279 (rank : 253)	θ value	5.27518 (rank : 231)
Query Neighborhood Hits	266	Target Neighborhood Hits	1446	Shared Neighborhood Hits	55
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MGRN1_HUMAN
NC score	0.026769 (rank : 254)	θ value	0.62314 (rank : 164)
Query Neighborhood Hits	266	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MLL3_HUMAN
NC score	0.025677 (rank : 255)	θ value	4.03905 (rank : 219)
Query Neighborhood Hits	266	Target Neighborhood Hits	1644	Shared Neighborhood Hits	50
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DOK1_MOUSE
NC score	0.025066 (rank : 256)	θ value	1.81305 (rank : 188)
Query Neighborhood Hits	266	Target Neighborhood Hits	82	Shared Neighborhood Hits	6
SwissProt Accessions	P97465, Q9R213	Gene names	Dok1, Dok
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)).

FA47B_HUMAN
NC score	0.022971 (rank : 257)	θ value	2.36792 (rank : 198)
Query Neighborhood Hits	266	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

LIMK1_HUMAN
NC score	0.021556 (rank : 258)	θ value	1.06291 (rank : 176)
Query Neighborhood Hits	266	Target Neighborhood Hits	1005	Shared Neighborhood Hits	69
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.021055 (rank : 259)	θ value	1.06291 (rank : 177)
Query Neighborhood Hits	266	Target Neighborhood Hits	1008	Shared Neighborhood Hits	67
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

CF150_HUMAN
NC score	0.020463 (rank : 260)	θ value	6.88961 (rank : 240)
Query Neighborhood Hits	266	Target Neighborhood Hits	96	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

IGSF2_HUMAN
NC score	0.020131 (rank : 261)	θ value	0.813845 (rank : 170)
Query Neighborhood Hits	266	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

ZCPW1_MOUSE
NC score	0.018996 (rank : 262)	θ value	4.03905 (rank : 224)
Query Neighborhood Hits	266	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

RAI1_MOUSE
NC score	0.018545 (rank : 263)	θ value	1.38821 (rank : 183)
Query Neighborhood Hits	266	Target Neighborhood Hits	344	Shared Neighborhood Hits	11
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

TRAIP_HUMAN
NC score	0.017780 (rank : 264)	θ value	0.62314 (rank : 167)
Query Neighborhood Hits	266	Target Neighborhood Hits	780	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

SAMN1_MOUSE
NC score	0.017355 (rank : 265)	θ value	1.38821 (rank : 184)
Query Neighborhood Hits	266	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ANTOL_HUMAN
NC score	0.016659 (rank : 266)	θ value	5.27518 (rank : 226)
Query Neighborhood Hits	266	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

KU86_HUMAN
NC score	0.014850 (rank : 267)	θ value	4.03905 (rank : 217)
Query Neighborhood Hits	266	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	P13010, Q4VBQ5, Q9UCQ0, Q9UCQ1	Gene names	XRCC5, G22P2
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 2 (EC 3.6.1.-) (ATP-dependent DNA helicase II 80 kDa subunit) (Lupus Ku autoantigen protein p86) (Ku86) (Ku80) (86 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 85 kDa subunit) (CTCBF) (CTC85) (Nuclear factor IV) (DNA-repair protein XRCC5).

RUSC2_HUMAN
NC score	0.014757 (rank : 268)	θ value	5.27518 (rank : 238)
Query Neighborhood Hits	266	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

TSH1_HUMAN
NC score	0.014655 (rank : 269)	θ value	1.06291 (rank : 180)
Query Neighborhood Hits	266	Target Neighborhood Hits	558	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

GP158_HUMAN
NC score	0.014640 (rank : 270)	θ value	2.36792 (rank : 199)
Query Neighborhood Hits	266	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

NRBF2_MOUSE
NC score	0.014501 (rank : 271)	θ value	6.88961 (rank : 245)
Query Neighborhood Hits	266	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VCQ3, Q9DCG3	Gene names	Nrbf2
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2).

KIF4A_MOUSE
NC score	0.013912 (rank : 272)	θ value	0.0431538 (rank : 121)
Query Neighborhood Hits	266	Target Neighborhood Hits	1033	Shared Neighborhood Hits	27
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

JIP4_MOUSE
NC score	0.013731 (rank : 273)	θ value	5.27518 (rank : 229)
Query Neighborhood Hits	266	Target Neighborhood Hits	593	Shared Neighborhood Hits	22
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

HUCE1_MOUSE
NC score	0.013378 (rank : 274)	θ value	5.27518 (rank : 228)
Query Neighborhood Hits	266	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DB85, Q8BHW3	Gene names
Domain Architecture	No domain graphic available
Description	Cerebral protein 1 homolog.

GA2L1_MOUSE
NC score	0.013107 (rank : 275)	θ value	6.88961 (rank : 242)
Query Neighborhood Hits	266	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

HUWE1_MOUSE
NC score	0.012867 (rank : 276)	θ value	2.36792 (rank : 202)
Query Neighborhood Hits	266	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TPR_HUMAN
NC score	0.012806 (rank : 277)	θ value	1.38821 (rank : 186)
Query Neighborhood Hits	266	Target Neighborhood Hits	1921	Shared Neighborhood Hits	55
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

RPO3D_MOUSE
NC score	0.012379 (rank : 278)	θ value	6.88961 (rank : 249)
Query Neighborhood Hits	266	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WD1, Q9CZ02	Gene names	Polr3d, Bn51t
Domain Architecture
Description	DNA-directed RNA polymerase III subunit D (EC 2.7.7.6) (DNA-directed RNA polymerase III 47 kDa polypeptide) (RNA polymerase C subunit 4) (RPC4).

CGRE1_MOUSE
NC score	0.012116 (rank : 279)	θ value	6.88961 (rank : 241)
Query Neighborhood Hits	266	Target Neighborhood Hits	173	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

GA2L2_HUMAN
NC score	0.011532 (rank : 280)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	266	Target Neighborhood Hits	175	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

BAZ2B_HUMAN
NC score	0.011334 (rank : 281)	θ value	3.0926 (rank : 207)
Query Neighborhood Hits	266	Target Neighborhood Hits	803	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

PCNT_HUMAN
NC score	0.011301 (rank : 282)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	266	Target Neighborhood Hits	1551	Shared Neighborhood Hits	40
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

GOGA1_MOUSE
NC score	0.011292 (rank : 283)	θ value	1.81305 (rank : 189)
Query Neighborhood Hits	266	Target Neighborhood Hits	994	Shared Neighborhood Hits	27
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

HUWE1_HUMAN
NC score	0.011100 (rank : 284)	θ value	3.0926 (rank : 210)
Query Neighborhood Hits	266	Target Neighborhood Hits	443	Shared Neighborhood Hits	16
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

CALD1_HUMAN
NC score	0.010768 (rank : 285)	θ value	4.03905 (rank : 213)
Query Neighborhood Hits	266	Target Neighborhood Hits	959	Shared Neighborhood Hits	32
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CN145_MOUSE
NC score	0.010713 (rank : 286)	θ value	1.81305 (rank : 187)
Query Neighborhood Hits	266	Target Neighborhood Hits	916	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

SNX14_MOUSE
NC score	0.010304 (rank : 287)	θ value	6.88961 (rank : 251)
Query Neighborhood Hits	266	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHY8	Gene names	Snx14
Domain Architecture	No domain graphic available
Description	Sorting nexin-14.

PRKDC_MOUSE
NC score	0.009949 (rank : 288)	θ value	6.88961 (rank : 247)
Query Neighborhood Hits	266	Target Neighborhood Hits	92	Shared Neighborhood Hits	5
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

TSH1_MOUSE
NC score	0.009934 (rank : 289)	θ value	4.03905 (rank : 223)
Query Neighborhood Hits	266	Target Neighborhood Hits	675	Shared Neighborhood Hits	7
SwissProt Accessions	Q5DTH5, Q6PE60, Q8VD19, Q9JLD5	Gene names	Tshz1, Kiaa4206, Sdccag33, Tsh1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3 homolog).

NIN_HUMAN
NC score	0.009679 (rank : 290)	θ value	6.88961 (rank : 244)
Query Neighborhood Hits	266	Target Neighborhood Hits	1416	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

HDAC9_HUMAN
NC score	0.009369 (rank : 291)	θ value	1.81305 (rank : 191)
Query Neighborhood Hits	266	Target Neighborhood Hits	201	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

CP135_MOUSE
NC score	0.009309 (rank : 292)	θ value	3.0926 (rank : 208)
Query Neighborhood Hits	266	Target Neighborhood Hits	1278	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

PUM1_HUMAN
NC score	0.009124 (rank : 293)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	266	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q14671, Q5VXY7, Q9HAN1	Gene names	PUM1, KIAA0099, PUMH1
Domain Architecture
Description	Pumilio homolog 1 (Pumilio-1) (HsPUM).

PUM1_MOUSE
NC score	0.009096 (rank : 294)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	266	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	Q80U78, Q80X96, Q80YU8, Q8BPV7, Q9EPU6	Gene names	Pum1, Kiaa0099
Domain Architecture
Description	Pumilio homolog 1.

RHBD4_HUMAN
NC score	0.008723 (rank : 295)	θ value	5.27518 (rank : 237)
Query Neighborhood Hits	266	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P58872	Gene names	RHBDL4, VRHO
Domain Architecture
Description	Rhomboid-related protein 4 (EC 3.4.21.105) (Ventrhoid transmembrane protein).

POLK_MOUSE
NC score	0.008609 (rank : 296)	θ value	6.88961 (rank : 246)
Query Neighborhood Hits	266	Target Neighborhood Hits	66	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QUG2, Q7TPY7	Gene names	Polk, Dinb1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

KIF3C_HUMAN
NC score	0.008339 (rank : 297)	θ value	5.27518 (rank : 230)
Query Neighborhood Hits	266	Target Neighborhood Hits	478	Shared Neighborhood Hits	20
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

MYO6_HUMAN
NC score	0.008114 (rank : 298)	θ value	1.38821 (rank : 181)
Query Neighborhood Hits	266	Target Neighborhood Hits	727	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

KCNH6_HUMAN
NC score	0.008082 (rank : 299)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	266	Target Neighborhood Hits	222	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

JADE1_HUMAN
NC score	0.007718 (rank : 300)	θ value	6.88961 (rank : 243)
Query Neighborhood Hits	266	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q6IE81, Q4W5D5, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692	Gene names	PHF17, JADE1, KIAA1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

SIA7A_HUMAN
NC score	0.007579 (rank : 301)	θ value	6.88961 (rank : 250)
Query Neighborhood Hits	266	Target Neighborhood Hits	177	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

DOCK9_HUMAN
NC score	0.007447 (rank : 302)	θ value	4.03905 (rank : 214)
Query Neighborhood Hits	266	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

RHG04_HUMAN
NC score	0.007427 (rank : 303)	θ value	3.0926 (rank : 211)
Query Neighborhood Hits	266	Target Neighborhood Hits	307	Shared Neighborhood Hits	14
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

JADE1_MOUSE
NC score	0.007105 (rank : 304)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

CE290_HUMAN
NC score	0.006638 (rank : 305)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	266	Target Neighborhood Hits	1553	Shared Neighborhood Hits	39
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

NKTR_HUMAN
NC score	0.006511 (rank : 306)	θ value	5.27518 (rank : 234)
Query Neighborhood Hits	266	Target Neighborhood Hits	658	Shared Neighborhood Hits	19
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RHG18_HUMAN
NC score	0.005874 (rank : 307)	θ value	6.88961 (rank : 248)
Query Neighborhood Hits	266	Target Neighborhood Hits	90	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

GRLF1_HUMAN
NC score	0.004132 (rank : 308)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	266	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

ATS17_HUMAN
NC score	-0.000001 (rank : 309)	θ value	6.88961 (rank : 239)
Query Neighborhood Hits	266	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

NOTC1_MOUSE
NC score	-0.000292 (rank : 310)	θ value	1.81305 (rank : 194)
Query Neighborhood Hits	266	Target Neighborhood Hits	916	Shared Neighborhood Hits	12
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

FOG2_HUMAN
NC score	-0.000781 (rank : 311)	θ value	4.03905 (rank : 215)
Query Neighborhood Hits	266	Target Neighborhood Hits	731	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WW38, Q9NPL7, Q9NPS4, Q9UNI5	Gene names	ZFPM2, FOG2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM2 (Zinc finger protein multitype 2) (Friend of GATA protein 2) (FOG-2) (hFOG-2).

NEK1_MOUSE
NC score	-0.001000 (rank : 312)	θ value	4.03905 (rank : 220)
Query Neighborhood Hits	266	Target Neighborhood Hits	1311	Shared Neighborhood Hits	27
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

DSG3_MOUSE
NC score	-0.001672 (rank : 313)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	266	Target Neighborhood Hits	160	Shared Neighborhood Hits	2
SwissProt Accessions	O35902, Q8CB02, Q8CE48	Gene names	Dsg3
Domain Architecture	No domain graphic available
Description	Desmoglein-3 precursor (130 kDa pemphigus vulgaris antigen homolog).

EGR2_MOUSE
NC score	-0.003473 (rank : 314)	θ value	0.47712 (rank : 158)
Query Neighborhood Hits	266	Target Neighborhood Hits	745	Shared Neighborhood Hits	5
SwissProt Accessions	P08152	Gene names	Egr2, Egr-2, Krox-20, Zfp-25
Domain Architecture	No domain graphic available
Description	Early growth response protein 2 (EGR-2) (Krox-20 protein).

ZFP92_MOUSE
NC score	-0.007277 (rank : 315)	θ value	4.03905 (rank : 225)
Query Neighborhood Hits	266	Target Neighborhood Hits	731	Shared Neighborhood Hits	5
SwissProt Accessions	Q62396	Gene names	Zfp92
Domain Architecture
Description	Zinc finger protein 92 (Zfp-92).