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Network neighborhood for query Sequence : HTRA4_HUMAN

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HTRA4_HUMAN
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HTRA4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA1_HUMAN
θ value	6.85399e-133 (rank : 2)	NC score	0.946024 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	75
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	1.29261e-131 (rank : 3)	NC score	0.947567 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	140	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA3_HUMAN
θ value	1.09934e-114 (rank : 4)	NC score	0.957509 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	152	Shared Neighborhood Hits	77
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	9.30652e-114 (rank : 5)	NC score	0.956735 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA2_MOUSE
θ value	6.73165e-80 (rank : 6)	NC score	0.911642 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	29	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
θ value	1.49966e-79 (rank : 7)	NC score	0.910634 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_HUMAN
θ value	4.59992e-12 (rank : 8)	NC score	0.442611 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	6.64225e-11 (rank : 9)	NC score	0.439981 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	230	Shared Neighborhood Hits	37
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

ESM1_HUMAN
θ value	2.88788e-06 (rank : 10)	NC score	0.355661 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

NOV_HUMAN
θ value	1.09739e-05 (rank : 11)	NC score	0.273916 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	33
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
θ value	4.1701e-05 (rank : 12)	NC score	0.265940 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	130	Shared Neighborhood Hits	32
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

WISP2_HUMAN
θ value	9.29e-05 (rank : 13)	NC score	0.281926 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

ESM1_MOUSE
θ value	0.000121331 (rank : 14)	NC score	0.374749 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	107	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

CTGF_HUMAN
θ value	0.00102713 (rank : 15)	NC score	0.273370 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CYR61_HUMAN
θ value	0.00134147 (rank : 16)	NC score	0.276336 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	159	Shared Neighborhood Hits	32
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
θ value	0.00134147 (rank : 17)	NC score	0.276882 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CTGF_MOUSE
θ value	0.00175202 (rank : 18)	NC score	0.243779 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

KAZD1_MOUSE
θ value	0.00298849 (rank : 19)	NC score	0.336980 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

WISP2_MOUSE
θ value	0.00390308 (rank : 20)	NC score	0.246864 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

KAZD1_HUMAN
θ value	0.00869519 (rank : 21)	NC score	0.352713 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	248	Shared Neighborhood Hits	39
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

AGRIN_HUMAN
θ value	0.0148317 (rank : 22)	NC score	0.099793 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	582	Shared Neighborhood Hits	42
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

PZRN3_MOUSE
θ value	0.0252991 (rank : 23)	NC score	0.075723 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	447	Shared Neighborhood Hits	36
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

SYNP2_HUMAN
θ value	0.0431538 (rank : 24)	NC score	0.065863 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	323	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

LCE1B_HUMAN
θ value	0.0563607 (rank : 25)	NC score	0.254659 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

PDZD7_HUMAN
θ value	0.0563607 (rank : 26)	NC score	0.081698 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	181	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PZRN3_HUMAN
θ value	0.0563607 (rank : 27)	NC score	0.074963 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	461	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZD1_MOUSE
θ value	0.0736092 (rank : 28)	NC score	0.127482 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SLIT1_HUMAN
θ value	0.0736092 (rank : 29)	NC score	0.016390 (rank : 134)
Query Neighborhood Hits	119	Target Neighborhood Hits	700	Shared Neighborhood Hits	23
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

WISP3_HUMAN
θ value	0.0736092 (rank : 30)	NC score	0.248787 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	87	Shared Neighborhood Hits	31
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

LCE1C_HUMAN
θ value	0.0961366 (rank : 31)	NC score	0.283922 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1E_HUMAN
θ value	0.0961366 (rank : 32)	NC score	0.308268 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

PDZD1_HUMAN
θ value	0.125558 (rank : 33)	NC score	0.125308 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PZRN4_HUMAN
θ value	0.125558 (rank : 34)	NC score	0.082182 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	438	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

WISP1_HUMAN
θ value	0.125558 (rank : 35)	NC score	0.204720 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	121	Shared Neighborhood Hits	27
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

WISP1_MOUSE
θ value	0.125558 (rank : 36)	NC score	0.214495 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

FST_HUMAN
θ value	0.163984 (rank : 37)	NC score	0.108575 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

SYNP2_MOUSE
θ value	0.163984 (rank : 38)	NC score	0.065036 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	252	Shared Neighborhood Hits	28
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

FST_MOUSE
θ value	0.21417 (rank : 39)	NC score	0.107763 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	27
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

IBP5_HUMAN
θ value	0.21417 (rank : 40)	NC score	0.176116 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	0.21417 (rank : 41)	NC score	0.176617 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

ISK5_HUMAN
θ value	0.21417 (rank : 42)	NC score	0.093647 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

KRA24_HUMAN
θ value	0.21417 (rank : 43)	NC score	0.035290 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	192	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

TNR14_HUMAN
θ value	0.21417 (rank : 44)	NC score	0.035262 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	149	Shared Neighborhood Hits	10
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

FSTL4_MOUSE
θ value	0.365318 (rank : 45)	NC score	0.058397 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	333	Shared Neighborhood Hits	22
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

LCE1A_HUMAN
θ value	0.365318 (rank : 46)	NC score	0.175968 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1F_HUMAN
θ value	0.365318 (rank : 47)	NC score	0.156675 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE2D_HUMAN
θ value	0.365318 (rank : 48)	NC score	0.138330 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

RHPN1_MOUSE
θ value	0.365318 (rank : 49)	NC score	0.083036 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

IPK1_HUMAN
θ value	0.47712 (rank : 50)	NC score	0.135539 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

CRIM1_HUMAN
θ value	0.62314 (rank : 51)	NC score	0.156080 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	362	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

HCN3_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.037314 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.037408 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

IBP1_MOUSE
θ value	0.62314 (rank : 54)	NC score	0.176540 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	97	Shared Neighborhood Hits	34
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP2_HUMAN
θ value	0.813845 (rank : 55)	NC score	0.175070 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

ISK3_MOUSE
θ value	0.813845 (rank : 56)	NC score	0.154031 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

LCE2B_HUMAN
θ value	0.813845 (rank : 57)	NC score	0.136097 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE5A_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.143125 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

FSTL4_HUMAN
θ value	1.06291 (rank : 59)	NC score	0.043355 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	344	Shared Neighborhood Hits	20
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

NOS1_HUMAN
θ value	1.06291 (rank : 60)	NC score	0.042706 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	218	Shared Neighborhood Hits	34
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

RHPN1_HUMAN
θ value	1.06291 (rank : 61)	NC score	0.081569 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

WHRN_HUMAN
θ value	1.06291 (rank : 62)	NC score	0.085575 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	1.06291 (rank : 63)	NC score	0.086617 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	412	Shared Neighborhood Hits	45
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

IBP3_HUMAN
θ value	1.38821 (rank : 64)	NC score	0.194866 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

PDZD3_HUMAN
θ value	1.38821 (rank : 65)	NC score	0.098739 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

TX1B3_HUMAN
θ value	1.38821 (rank : 66)	NC score	0.088432 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	1.38821 (rank : 67)	NC score	0.087915 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

GRASP_HUMAN
θ value	1.81305 (rank : 68)	NC score	0.069859 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	147	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	1.81305 (rank : 69)	NC score	0.066096 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

LAP4_HUMAN
θ value	1.81305 (rank : 70)	NC score	0.051508 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	608	Shared Neighborhood Hits	47
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

HCN4_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.032995 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	303	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.033214 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	284	Shared Neighborhood Hits	10
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

NOTC1_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.013316 (rank : 137)
Query Neighborhood Hits	119	Target Neighborhood Hits	906	Shared Neighborhood Hits	25
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_MOUSE
θ value	2.36792 (rank : 74)	NC score	0.015263 (rank : 136)
Query Neighborhood Hits	119	Target Neighborhood Hits	916	Shared Neighborhood Hits	31
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

CHRD_MOUSE
θ value	3.0926 (rank : 75)	NC score	0.017761 (rank : 133)
Query Neighborhood Hits	119	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

IBP2_MOUSE
θ value	3.0926 (rank : 76)	NC score	0.162289 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	29
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

FSTL3_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.116463 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	152	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

KR107_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.028091 (rank : 126)
Query Neighborhood Hits	119	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

LCE2C_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.105451 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

RPGF6_HUMAN
θ value	4.03905 (rank : 80)	NC score	0.048137 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SPR2B_MOUSE
θ value	4.03905 (rank : 81)	NC score	0.052928 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	51	Shared Neighborhood Hits	7
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

ARHGC_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.043343 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CFAI_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.002383 (rank : 143)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

HCN2_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.031298 (rank : 122)
Query Neighborhood Hits	119	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	5.27518 (rank : 85)	NC score	0.031597 (rank : 121)
Query Neighborhood Hits	119	Target Neighborhood Hits	278	Shared Neighborhood Hits	10
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

KR108_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.037942 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	226	Shared Neighborhood Hits	19
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

LCE1D_HUMAN
θ value	5.27518 (rank : 87)	NC score	0.244173 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

MCSP_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.037908 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

PSCBP_HUMAN
θ value	5.27518 (rank : 89)	NC score	0.059617 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

SEM4G_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.003778 (rank : 139)
Query Neighborhood Hits	119	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUH7	Gene names	Sema4g
Domain Architecture
Description	Semaphorin-4G precursor.

ZO2_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.040613 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.039476 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ARHGC_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.042424 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	344	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EMR1_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.005034 (rank : 138)
Query Neighborhood Hits	119	Target Neighborhood Hits	349	Shared Neighborhood Hits	9
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

MAST2_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.003708 (rank : 141)
Query Neighborhood Hits	119	Target Neighborhood Hits	1189	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST4_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.003725 (rank : 140)
Query Neighborhood Hits	119	Target Neighborhood Hits	1804	Shared Neighborhood Hits	40
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NOS1_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.031613 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDZD3_MOUSE
θ value	6.88961 (rank : 98)	NC score	0.102128 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

USH1C_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.075866 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	327	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.071683 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	557	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

ZO3_MOUSE
θ value	6.88961 (rank : 101)	NC score	0.062026 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

APBA2_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.023502 (rank : 131)
Query Neighborhood Hits	119	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	8.99809 (rank : 103)	NC score	0.023507 (rank : 130)
Query Neighborhood Hits	119	Target Neighborhood Hits	219	Shared Neighborhood Hits	31
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

DLG5_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.030342 (rank : 125)
Query Neighborhood Hits	119	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FSTL3_HUMAN
θ value	8.99809 (rank : 105)	NC score	0.121197 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	162	Shared Neighborhood Hits	23
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

HCN1_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.031289 (rank : 123)
Query Neighborhood Hits	119	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.031067 (rank : 124)
Query Neighborhood Hits	119	Target Neighborhood Hits	172	Shared Neighborhood Hits	9
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

IBP3_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.148020 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

KR106_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.031916 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR171_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.035340 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

LAP4_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.045265 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	590	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LCE4A_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.098446 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

MAST3_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.003300 (rank : 142)
Query Neighborhood Hits	119	Target Neighborhood Hits	1128	Shared Neighborhood Hits	35
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

NFX1_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.024687 (rank : 129)
Query Neighborhood Hits	119	Target Neighborhood Hits	405	Shared Neighborhood Hits	20
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

PAR6B_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.026488 (rank : 128)
Query Neighborhood Hits	119	Target Neighborhood Hits	126	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_MOUSE
θ value	8.99809 (rank : 116)	NC score	0.027179 (rank : 127)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PGBM_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.018766 (rank : 132)
Query Neighborhood Hits	119	Target Neighborhood Hits	1113	Shared Neighborhood Hits	24
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

RECK_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.062530 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	189	Shared Neighborhood Hits	31
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

SPR2H_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.015598 (rank : 135)
Query Neighborhood Hits	119	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

FSTL1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.056683 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.055893 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	74	Shared Neighborhood Hits	17
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

IBP1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.135226 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP4_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.126975 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.122966 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	22
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP6_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.068173 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP6_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.064824 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

ISK6_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.050862 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK6_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.069666 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

LCE2A_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.081768 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

MPDZ_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.051154 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

NHERF_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.092119 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.088241 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	195	Shared Neighborhood Hits	44
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.075502 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	197	Shared Neighborhood Hits	43
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.068781 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

PDZ11_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.123402 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	160	Shared Neighborhood Hits	43
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.122009 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZK4_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.076220 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	165	Shared Neighborhood Hits	30
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.076711 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

RECK_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.058725 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

SDCB1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.054428 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.050246 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

TEFF2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.065173 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	211	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.068169 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

Hits sorted by NC score

HTRA4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA3_HUMAN
NC score	0.957509 (rank : 2)	θ value	1.09934e-114 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	152	Shared Neighborhood Hits	77
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
NC score	0.956735 (rank : 3)	θ value	9.30652e-114 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA1_MOUSE
NC score	0.947567 (rank : 4)	θ value	1.29261e-131 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	140	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA1_HUMAN
NC score	0.946024 (rank : 5)	θ value	6.85399e-133 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	75
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA2_MOUSE
NC score	0.911642 (rank : 6)	θ value	6.73165e-80 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	29	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
NC score	0.910634 (rank : 7)	θ value	1.49966e-79 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP7_HUMAN
NC score	0.442611 (rank : 8)	θ value	4.59992e-12 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	220	Shared Neighborhood Hits	39
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
NC score	0.439981 (rank : 9)	θ value	6.64225e-11 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	230	Shared Neighborhood Hits	37
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

ESM1_MOUSE
NC score	0.374749 (rank : 10)	θ value	0.000121331 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	107	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_HUMAN
NC score	0.355661 (rank : 11)	θ value	2.88788e-06 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

KAZD1_HUMAN
NC score	0.352713 (rank : 12)	θ value	0.00869519 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	248	Shared Neighborhood Hits	39
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
NC score	0.336980 (rank : 13)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

LCE1E_HUMAN
NC score	0.308268 (rank : 14)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1C_HUMAN
NC score	0.283922 (rank : 15)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

WISP2_HUMAN
NC score	0.281926 (rank : 16)	θ value	9.29e-05 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

CYR61_MOUSE
NC score	0.276882 (rank : 17)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CYR61_HUMAN
NC score	0.276336 (rank : 18)	θ value	0.00134147 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	159	Shared Neighborhood Hits	32
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

NOV_HUMAN
NC score	0.273916 (rank : 19)	θ value	1.09739e-05 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	33
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CTGF_HUMAN
NC score	0.273370 (rank : 20)	θ value	0.00102713 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	36
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

NOV_MOUSE
NC score	0.265940 (rank : 21)	θ value	4.1701e-05 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	130	Shared Neighborhood Hits	32
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

LCE1B_HUMAN
NC score	0.254659 (rank : 22)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

WISP3_HUMAN
NC score	0.248787 (rank : 23)	θ value	0.0736092 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	87	Shared Neighborhood Hits	31
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

WISP2_MOUSE
NC score	0.246864 (rank : 24)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

LCE1D_HUMAN
NC score	0.244173 (rank : 25)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	44	Shared Neighborhood Hits	8
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

CTGF_MOUSE
NC score	0.243779 (rank : 26)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	124	Shared Neighborhood Hits	33
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

WISP1_MOUSE
NC score	0.214495 (rank : 27)	θ value	0.125558 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
NC score	0.204720 (rank : 28)	θ value	0.125558 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	121	Shared Neighborhood Hits	27
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

IBP3_HUMAN
NC score	0.194866 (rank : 29)	θ value	1.38821 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP5_MOUSE
NC score	0.176617 (rank : 30)	θ value	0.21417 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP1_MOUSE
NC score	0.176540 (rank : 31)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	97	Shared Neighborhood Hits	34
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP5_HUMAN
NC score	0.176116 (rank : 32)	θ value	0.21417 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

LCE1A_HUMAN
NC score	0.175968 (rank : 33)	θ value	0.365318 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

IBP2_HUMAN
NC score	0.175070 (rank : 34)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP2_MOUSE
NC score	0.162289 (rank : 35)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	29
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

LCE1F_HUMAN
NC score	0.156675 (rank : 36)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	48	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

CRIM1_HUMAN
NC score	0.156080 (rank : 37)	θ value	0.62314 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	362	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

ISK3_MOUSE
NC score	0.154031 (rank : 38)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

IBP3_MOUSE
NC score	0.148020 (rank : 39)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

LCE5A_HUMAN
NC score	0.143125 (rank : 40)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	43	Shared Neighborhood Hits	4
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

LCE2D_HUMAN
NC score	0.138330 (rank : 41)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE2B_HUMAN
NC score	0.136097 (rank : 42)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

IPK1_HUMAN
NC score	0.135539 (rank : 43)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

IBP1_HUMAN
NC score	0.135226 (rank : 44)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	119	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

PDZD1_MOUSE
NC score	0.127482 (rank : 45)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	191	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

IBP4_HUMAN
NC score	0.126975 (rank : 46)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	119	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

PDZD1_HUMAN
NC score	0.125308 (rank : 47)	θ value	0.125558 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZ11_HUMAN
NC score	0.123402 (rank : 48)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	119	Target Neighborhood Hits	160	Shared Neighborhood Hits	43
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

IBP4_MOUSE
NC score	0.122966 (rank : 49)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	22
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

PDZ11_MOUSE
NC score	0.122009 (rank : 50)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	119	Target Neighborhood Hits	154	Shared Neighborhood Hits	41
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

FSTL3_HUMAN
NC score	0.121197 (rank : 51)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	162	Shared Neighborhood Hits	23
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FSTL3_MOUSE
NC score	0.116463 (rank : 52)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	152	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FST_HUMAN
NC score	0.108575 (rank : 53)	θ value	0.163984 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	129	Shared Neighborhood Hits	24
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

FST_MOUSE
NC score	0.107763 (rank : 54)	θ value	0.21417 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	27
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

LCE2C_HUMAN
NC score	0.105451 (rank : 55)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	6
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

PDZD3_MOUSE
NC score	0.102128 (rank : 56)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

AGRIN_HUMAN
NC score	0.099793 (rank : 57)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	582	Shared Neighborhood Hits	42
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

PDZD3_HUMAN
NC score	0.098739 (rank : 58)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	180	Shared Neighborhood Hits	43
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

LCE4A_HUMAN
NC score	0.098446 (rank : 59)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

ISK5_HUMAN
NC score	0.093647 (rank : 60)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

NHERF_HUMAN
NC score	0.092119 (rank : 61)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

TX1B3_HUMAN
NC score	0.088432 (rank : 62)	θ value	1.38821 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

NHERF_MOUSE
NC score	0.088241 (rank : 63)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	119	Target Neighborhood Hits	195	Shared Neighborhood Hits	44
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

TX1B3_MOUSE
NC score	0.087915 (rank : 64)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

WHRN_MOUSE
NC score	0.086617 (rank : 65)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	412	Shared Neighborhood Hits	45
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WHRN_HUMAN
NC score	0.085575 (rank : 66)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

RHPN1_MOUSE
NC score	0.083036 (rank : 67)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PZRN4_HUMAN
NC score	0.082182 (rank : 68)	θ value	0.125558 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	438	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

LCE2A_HUMAN
NC score	0.081768 (rank : 69)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	119	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

PDZD7_HUMAN
NC score	0.081698 (rank : 70)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	181	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

RHPN1_HUMAN
NC score	0.081569 (rank : 71)	θ value	1.06291 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PDZK4_MOUSE
NC score	0.076711 (rank : 72)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	119	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.076220 (rank : 73)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	119	Target Neighborhood Hits	165	Shared Neighborhood Hits	30
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

USH1C_HUMAN
NC score	0.075866 (rank : 74)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	327	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PZRN3_MOUSE
NC score	0.075723 (rank : 75)	θ value	0.0252991 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	447	Shared Neighborhood Hits	36
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

NHRF2_HUMAN
NC score	0.075502 (rank : 76)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	119	Target Neighborhood Hits	197	Shared Neighborhood Hits	43
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PZRN3_HUMAN
NC score	0.074963 (rank : 77)	θ value	0.0563607 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	461	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

USH1C_MOUSE
NC score	0.071683 (rank : 78)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	557	Shared Neighborhood Hits	44
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GRASP_HUMAN
NC score	0.069859 (rank : 79)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	147	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

ISK6_MOUSE
NC score	0.069666 (rank : 80)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	119	Target Neighborhood Hits	37	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

NHRF2_MOUSE
NC score	0.068781 (rank : 81)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	119	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

IBP6_HUMAN
NC score	0.068173 (rank : 82)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

TEFF2_MOUSE
NC score	0.068169 (rank : 83)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	119	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

GRASP_MOUSE
NC score	0.066096 (rank : 84)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	131	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SYNP2_HUMAN
NC score	0.065863 (rank : 85)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	323	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

TEFF2_HUMAN
NC score	0.065173 (rank : 86)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	119	Target Neighborhood Hits	211	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

SYNP2_MOUSE
NC score	0.065036 (rank : 87)	θ value	0.163984 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	252	Shared Neighborhood Hits	28
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

IBP6_MOUSE
NC score	0.064824 (rank : 88)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	119	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

RECK_HUMAN
NC score	0.062530 (rank : 89)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	189	Shared Neighborhood Hits	31
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

ZO3_MOUSE
NC score	0.062026 (rank : 90)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

PSCBP_HUMAN
NC score	0.059617 (rank : 91)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

RECK_MOUSE
NC score	0.058725 (rank : 92)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	119	Target Neighborhood Hits	158	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

FSTL4_MOUSE
NC score	0.058397 (rank : 93)	θ value	0.365318 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	333	Shared Neighborhood Hits	22
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL1_HUMAN
NC score	0.056683 (rank : 94)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
NC score	0.055893 (rank : 95)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	119	Target Neighborhood Hits	74	Shared Neighborhood Hits	17
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

SDCB1_HUMAN
NC score	0.054428 (rank : 96)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	119	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SPR2B_MOUSE
NC score	0.052928 (rank : 97)	θ value	4.03905 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	51	Shared Neighborhood Hits	7
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

LAP4_HUMAN
NC score	0.051508 (rank : 98)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	608	Shared Neighborhood Hits	47
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

MPDZ_MOUSE
NC score	0.051154 (rank : 99)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	119	Target Neighborhood Hits	298	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

ISK6_HUMAN
NC score	0.050862 (rank : 100)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	119	Target Neighborhood Hits	32	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

SDCB1_MOUSE
NC score	0.050246 (rank : 101)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	36
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

RPGF6_HUMAN
NC score	0.048137 (rank : 102)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	266	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

LAP4_MOUSE
NC score	0.045265 (rank : 103)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	590	Shared Neighborhood Hits	47
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

FSTL4_HUMAN
NC score	0.043355 (rank : 104)	θ value	1.06291 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	344	Shared Neighborhood Hits	20
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

ARHGC_HUMAN
NC score	0.043343 (rank : 105)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	351	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

NOS1_HUMAN
NC score	0.042706 (rank : 106)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	218	Shared Neighborhood Hits	34
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ARHGC_MOUSE
NC score	0.042424 (rank : 107)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	344	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ZO2_HUMAN
NC score	0.040613 (rank : 108)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
NC score	0.039476 (rank : 109)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	296	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

KR108_HUMAN
NC score	0.037942 (rank : 110)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	226	Shared Neighborhood Hits	19
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

MCSP_MOUSE
NC score	0.037908 (rank : 111)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	108	Shared Neighborhood Hits	10
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

HCN3_MOUSE
NC score	0.037408 (rank : 112)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN3_HUMAN
NC score	0.037314 (rank : 113)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

KR171_HUMAN
NC score	0.035340 (rank : 114)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYP8	Gene names	KRTAP17-1, KAP17.1, KRTAP16.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 17-1 (Keratin-associated protein 16.1).

KRA24_HUMAN
NC score	0.035290 (rank : 115)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	192	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

TNR14_HUMAN
NC score	0.035262 (rank : 116)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	149	Shared Neighborhood Hits	10
SwissProt Accessions	Q92956, Q8WXR1, Q96J31, Q9UM65	Gene names	TNFRSF14, HVEA, HVEM
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 14 precursor (Herpesvirus entry mediator A) (Tumor necrosis factor receptor-like 2) (TR2).

HCN4_MOUSE
NC score	0.033214 (rank : 117)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	284	Shared Neighborhood Hits	10
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN4_HUMAN
NC score	0.032995 (rank : 118)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	303	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

KR106_HUMAN
NC score	0.031916 (rank : 119)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	347	Shared Neighborhood Hits	23
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

NOS1_MOUSE
NC score	0.031613 (rank : 120)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

HCN2_MOUSE
NC score	0.031597 (rank : 121)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	278	Shared Neighborhood Hits	10
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN2_HUMAN
NC score	0.031298 (rank : 122)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	369	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN1_HUMAN
NC score	0.031289 (rank : 123)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
NC score	0.031067 (rank : 124)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	172	Shared Neighborhood Hits	9
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

DLG5_HUMAN
NC score	0.030342 (rank : 125)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

KR107_HUMAN
NC score	0.028091 (rank : 126)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	330	Shared Neighborhood Hits	22
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

PAR6B_MOUSE
NC score	0.027179 (rank : 127)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6B_HUMAN
NC score	0.026488 (rank : 128)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	126	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

NFX1_HUMAN
NC score	0.024687 (rank : 129)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	405	Shared Neighborhood Hits	20
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

APBA2_MOUSE
NC score	0.023507 (rank : 130)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	219	Shared Neighborhood Hits	31
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.023502 (rank : 131)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	220	Shared Neighborhood Hits	31
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

PGBM_HUMAN
NC score	0.018766 (rank : 132)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	1113	Shared Neighborhood Hits	24
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CHRD_MOUSE
NC score	0.017761 (rank : 133)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

SLIT1_HUMAN
NC score	0.016390 (rank : 134)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	700	Shared Neighborhood Hits	23
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

SPR2H_MOUSE
NC score	0.015598 (rank : 135)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

NOTC1_MOUSE
NC score	0.015263 (rank : 136)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	916	Shared Neighborhood Hits	31
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_HUMAN
NC score	0.013316 (rank : 137)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	906	Shared Neighborhood Hits	25
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

EMR1_MOUSE
NC score	0.005034 (rank : 138)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	349	Shared Neighborhood Hits	9
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

SEM4G_MOUSE
NC score	0.003778 (rank : 139)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUH7	Gene names	Sema4g
Domain Architecture
Description	Semaphorin-4G precursor.

MAST4_HUMAN
NC score	0.003725 (rank : 140)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	1804	Shared Neighborhood Hits	40
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.003708 (rank : 141)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	1189	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
NC score	0.003300 (rank : 142)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	1128	Shared Neighborhood Hits	35
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

CFAI_HUMAN
NC score	0.002383 (rank : 143)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].