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Network neighborhood for query Sequence : PZRN4_HUMAN

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PZRN4_HUMAN
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PZRN3_HUMAN
θ value	0 (rank : 1)	NC score	0.960133 (rank : 3)
Query Neighborhood Hits	438	Target Neighborhood Hits	461	Shared Neighborhood Hits	328
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
θ value	0 (rank : 2)	NC score	0.962255 (rank : 2)
Query Neighborhood Hits	438	Target Neighborhood Hits	447	Shared Neighborhood Hits	333
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	438	Target Neighborhood Hits	438	Shared Neighborhood Hits	438
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PDZK4_MOUSE
θ value	4.6918e-174 (rank : 4)	NC score	0.832430 (rank : 4)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
θ value	1.04765e-165 (rank : 5)	NC score	0.829980 (rank : 5)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

LAP4_MOUSE
θ value	5.99374e-20 (rank : 6)	NC score	0.421143 (rank : 78)
Query Neighborhood Hits	438	Target Neighborhood Hits	590	Shared Neighborhood Hits	161
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

INADL_HUMAN
θ value	3.88503e-19 (rank : 7)	NC score	0.650100 (rank : 11)
Query Neighborhood Hits	438	Target Neighborhood Hits	260	Shared Neighborhood Hits	153
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

LAP4_HUMAN
θ value	5.07402e-19 (rank : 8)	NC score	0.423630 (rank : 77)
Query Neighborhood Hits	438	Target Neighborhood Hits	608	Shared Neighborhood Hits	165
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

INADL_MOUSE
θ value	9.56915e-18 (rank : 9)	NC score	0.649085 (rank : 12)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_HUMAN
θ value	9.56915e-18 (rank : 10)	NC score	0.640211 (rank : 13)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	160
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

RNF41_HUMAN
θ value	6.20254e-17 (rank : 11)	NC score	0.480790 (rank : 66)
Query Neighborhood Hits	438	Target Neighborhood Hits	226	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	6.20254e-17 (rank : 12)	NC score	0.481238 (rank : 65)
Query Neighborhood Hits	438	Target Neighborhood Hits	224	Shared Neighborhood Hits	157
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

MPDZ_MOUSE
θ value	1.52774e-15 (rank : 13)	NC score	0.635760 (rank : 14)
Query Neighborhood Hits	438	Target Neighborhood Hits	298	Shared Neighborhood Hits	154
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

DLG3_HUMAN
θ value	4.91457e-14 (rank : 14)	NC score	0.566356 (rank : 36)
Query Neighborhood Hits	438	Target Neighborhood Hits	269	Shared Neighborhood Hits	145
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	6.41864e-14 (rank : 15)	NC score	0.568154 (rank : 33)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	145
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_MOUSE
θ value	8.38298e-14 (rank : 16)	NC score	0.565254 (rank : 37)
Query Neighborhood Hits	438	Target Neighborhood Hits	285	Shared Neighborhood Hits	147
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

DLG4_HUMAN
θ value	1.09485e-13 (rank : 17)	NC score	0.578200 (rank : 28)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	147
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	1.42992e-13 (rank : 18)	NC score	0.578506 (rank : 27)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	147
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MAGI2_MOUSE
θ value	5.43371e-13 (rank : 19)	NC score	0.511227 (rank : 52)
Query Neighborhood Hits	438	Target Neighborhood Hits	370	Shared Neighborhood Hits	156
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

DLG1_HUMAN
θ value	7.09661e-13 (rank : 20)	NC score	0.566812 (rank : 34)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	148
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

MAGI2_HUMAN
θ value	2.28291e-11 (rank : 21)	NC score	0.507850 (rank : 55)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	156
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SYJ2B_HUMAN
θ value	2.98157e-11 (rank : 22)	NC score	0.699499 (rank : 6)
Query Neighborhood Hits	438	Target Neighborhood Hits	162	Shared Neighborhood Hits	137
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

WHRN_MOUSE
θ value	1.133e-10 (rank : 23)	NC score	0.579505 (rank : 26)
Query Neighborhood Hits	438	Target Neighborhood Hits	412	Shared Neighborhood Hits	154
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

TX1B3_HUMAN
θ value	1.47974e-10 (rank : 24)	NC score	0.612639 (rank : 15)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	136
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	1.47974e-10 (rank : 25)	NC score	0.609839 (rank : 16)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	133
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

DLG2_HUMAN
θ value	1.9326e-10 (rank : 26)	NC score	0.560305 (rank : 39)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	147
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
θ value	1.9326e-10 (rank : 27)	NC score	0.557427 (rank : 40)
Query Neighborhood Hits	438	Target Neighborhood Hits	271	Shared Neighborhood Hits	147
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

MAGI1_MOUSE
θ value	9.59137e-10 (rank : 28)	NC score	0.517826 (rank : 48)
Query Neighborhood Hits	438	Target Neighborhood Hits	403	Shared Neighborhood Hits	159
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
θ value	1.25267e-09 (rank : 29)	NC score	0.517539 (rank : 49)
Query Neighborhood Hits	438	Target Neighborhood Hits	388	Shared Neighborhood Hits	158
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

LNX2_HUMAN
θ value	2.13673e-09 (rank : 30)	NC score	0.679314 (rank : 9)
Query Neighborhood Hits	438	Target Neighborhood Hits	389	Shared Neighborhood Hits	306
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LIN7A_HUMAN
θ value	2.79066e-09 (rank : 31)	NC score	0.598303 (rank : 17)
Query Neighborhood Hits	438	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	2.79066e-09 (rank : 32)	NC score	0.598142 (rank : 18)
Query Neighborhood Hits	438	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LNX1_HUMAN
θ value	2.79066e-09 (rank : 33)	NC score	0.677138 (rank : 10)
Query Neighborhood Hits	438	Target Neighborhood Hits	379	Shared Neighborhood Hits	298
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

TRAF6_HUMAN
θ value	4.76016e-09 (rank : 34)	NC score	0.361680 (rank : 98)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

ZO1_HUMAN
θ value	4.76016e-09 (rank : 35)	NC score	0.490703 (rank : 62)
Query Neighborhood Hits	438	Target Neighborhood Hits	474	Shared Neighborhood Hits	155
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

LIN7B_HUMAN
θ value	8.11959e-09 (rank : 36)	NC score	0.595780 (rank : 20)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
θ value	1.06045e-08 (rank : 37)	NC score	0.595503 (rank : 21)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
θ value	1.06045e-08 (rank : 38)	NC score	0.592492 (rank : 22)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	1.06045e-08 (rank : 39)	NC score	0.592492 (rank : 23)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	154
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LNX2_MOUSE
θ value	1.06045e-08 (rank : 40)	NC score	0.692061 (rank : 7)
Query Neighborhood Hits	438	Target Neighborhood Hits	407	Shared Neighborhood Hits	309
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

SNTA1_MOUSE
θ value	1.06045e-08 (rank : 41)	NC score	0.493543 (rank : 59)
Query Neighborhood Hits	438	Target Neighborhood Hits	170	Shared Neighborhood Hits	126
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

LNX1_MOUSE
θ value	1.38499e-08 (rank : 42)	NC score	0.684533 (rank : 8)
Query Neighborhood Hits	438	Target Neighborhood Hits	377	Shared Neighborhood Hits	299
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

PTN13_MOUSE
θ value	1.38499e-08 (rank : 43)	NC score	0.339943 (rank : 105)
Query Neighborhood Hits	438	Target Neighborhood Hits	426	Shared Neighborhood Hits	152
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

ZO1_MOUSE
θ value	1.38499e-08 (rank : 44)	NC score	0.493246 (rank : 60)
Query Neighborhood Hits	438	Target Neighborhood Hits	453	Shared Neighborhood Hits	153
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PTN13_HUMAN
θ value	1.80886e-08 (rank : 45)	NC score	0.347937 (rank : 103)
Query Neighborhood Hits	438	Target Neighborhood Hits	471	Shared Neighborhood Hits	152
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

TRAF6_MOUSE
θ value	3.08544e-08 (rank : 46)	NC score	0.368507 (rank : 94)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	160
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

PAR3L_HUMAN
θ value	6.87365e-08 (rank : 47)	NC score	0.589780 (rank : 24)
Query Neighborhood Hits	438	Target Neighborhood Hits	297	Shared Neighborhood Hits	141
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

PDZD2_HUMAN
θ value	6.87365e-08 (rank : 48)	NC score	0.549380 (rank : 42)
Query Neighborhood Hits	438	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SNTB1_HUMAN
θ value	8.97725e-08 (rank : 49)	NC score	0.483776 (rank : 64)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	122
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

SNTB1_MOUSE
θ value	8.97725e-08 (rank : 50)	NC score	0.483781 (rank : 63)
Query Neighborhood Hits	438	Target Neighborhood Hits	160	Shared Neighborhood Hits	121
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

PARD3_MOUSE
θ value	1.17247e-07 (rank : 51)	NC score	0.572484 (rank : 31)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

SNTA1_HUMAN
θ value	1.17247e-07 (rank : 52)	NC score	0.493911 (rank : 58)
Query Neighborhood Hits	438	Target Neighborhood Hits	186	Shared Neighborhood Hits	130
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTB2_HUMAN
θ value	1.53129e-07 (rank : 53)	NC score	0.506831 (rank : 56)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	132
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTB2_MOUSE
θ value	1.53129e-07 (rank : 54)	NC score	0.507868 (rank : 54)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	132
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

TRAF5_MOUSE
θ value	1.53129e-07 (rank : 55)	NC score	0.313029 (rank : 117)
Query Neighborhood Hits	438	Target Neighborhood Hits	355	Shared Neighborhood Hits	137
SwissProt Accessions	P70191, Q61480	Gene names	Traf5
Domain Architecture
Description	TNF receptor-associated factor 5.

USH1C_HUMAN
θ value	2.61198e-07 (rank : 56)	NC score	0.585149 (rank : 25)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

ZN313_MOUSE
θ value	2.61198e-07 (rank : 57)	NC score	0.374697 (rank : 92)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	185
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

TRAF4_HUMAN
θ value	3.41135e-07 (rank : 58)	NC score	0.298293 (rank : 128)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BUZ4, O75615, Q14848, Q2PJN8	Gene names	TRAF4, CART1, MLN62, RNF83
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Malignant 62) (RING finger protein 83).

IL16_HUMAN
θ value	5.81887e-07 (rank : 59)	NC score	0.564269 (rank : 38)
Query Neighborhood Hits	438	Target Neighborhood Hits	207	Shared Neighborhood Hits	126
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

LRRC7_HUMAN
θ value	5.81887e-07 (rank : 60)	NC score	0.243508 (rank : 177)
Query Neighborhood Hits	438	Target Neighborhood Hits	423	Shared Neighborhood Hits	111
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

LRRC7_MOUSE
θ value	5.81887e-07 (rank : 61)	NC score	0.242479 (rank : 181)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

PARD3_HUMAN
θ value	5.81887e-07 (rank : 62)	NC score	0.577309 (rank : 29)
Query Neighborhood Hits	438	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

RN125_MOUSE
θ value	7.59969e-07 (rank : 63)	NC score	0.370044 (rank : 93)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

ZO3_MOUSE
θ value	7.59969e-07 (rank : 64)	NC score	0.513416 (rank : 51)
Query Neighborhood Hits	438	Target Neighborhood Hits	224	Shared Neighborhood Hits	155
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

IL16_MOUSE
θ value	9.92553e-07 (rank : 65)	NC score	0.551733 (rank : 41)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	123
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

TRAF7_MOUSE
θ value	9.92553e-07 (rank : 66)	NC score	0.195047 (rank : 239)
Query Neighborhood Hits	438	Target Neighborhood Hits	470	Shared Neighborhood Hits	145
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

PDZD1_MOUSE
θ value	1.29631e-06 (rank : 67)	NC score	0.492961 (rank : 61)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD7_HUMAN
θ value	1.29631e-06 (rank : 68)	NC score	0.596291 (rank : 19)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	143
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

SNTG2_HUMAN
θ value	1.69304e-06 (rank : 69)	NC score	0.502185 (rank : 57)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	144
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

TRAF5_HUMAN
θ value	1.69304e-06 (rank : 70)	NC score	0.304020 (rank : 122)
Query Neighborhood Hits	438	Target Neighborhood Hits	396	Shared Neighborhood Hits	136
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

NEB1_HUMAN
θ value	2.21117e-06 (rank : 71)	NC score	0.380260 (rank : 90)
Query Neighborhood Hits	438	Target Neighborhood Hits	829	Shared Neighborhood Hits	159
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

TRAF7_HUMAN
θ value	2.21117e-06 (rank : 72)	NC score	0.193477 (rank : 242)
Query Neighborhood Hits	438	Target Neighborhood Hits	482	Shared Neighborhood Hits	150
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

WHRN_HUMAN
θ value	2.88788e-06 (rank : 73)	NC score	0.576748 (rank : 30)
Query Neighborhood Hits	438	Target Neighborhood Hits	325	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

ZN313_HUMAN
θ value	2.88788e-06 (rank : 74)	NC score	0.367065 (rank : 96)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	181
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

RN125_HUMAN
θ value	3.77169e-06 (rank : 75)	NC score	0.367685 (rank : 95)
Query Neighborhood Hits	438	Target Neighborhood Hits	230	Shared Neighborhood Hits	164
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

ZO3_HUMAN
θ value	3.77169e-06 (rank : 76)	NC score	0.509606 (rank : 53)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	146
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

TRAF3_MOUSE
θ value	4.92598e-06 (rank : 77)	NC score	0.276480 (rank : 140)
Query Neighborhood Hits	438	Target Neighborhood Hits	476	Shared Neighborhood Hits	147
SwissProt Accessions	Q60803, Q62380	Gene names	Traf3, Craf1, Trafamn
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN).

DLG5_HUMAN
θ value	6.43352e-06 (rank : 78)	NC score	0.378808 (rank : 91)
Query Neighborhood Hits	438	Target Neighborhood Hits	1088	Shared Neighborhood Hits	197
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

RN166_MOUSE
θ value	6.43352e-06 (rank : 79)	NC score	0.350881 (rank : 101)
Query Neighborhood Hits	438	Target Neighborhood Hits	248	Shared Neighborhood Hits	166
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

TRAF3_HUMAN
θ value	6.43352e-06 (rank : 80)	NC score	0.276221 (rank : 142)
Query Neighborhood Hits	438	Target Neighborhood Hits	463	Shared Neighborhood Hits	141
SwissProt Accessions	Q13114, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1	Gene names	TRAF3, CAP1, CRAF1
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein) (LAP1) (CAP-1).

SNTG2_MOUSE
θ value	8.40245e-06 (rank : 81)	NC score	0.475996 (rank : 69)
Query Neighborhood Hits	438	Target Neighborhood Hits	176	Shared Neighborhood Hits	133
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

GRIP1_HUMAN
θ value	1.09739e-05 (rank : 82)	NC score	0.518412 (rank : 47)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	1.09739e-05 (rank : 83)	NC score	0.517095 (rank : 50)
Query Neighborhood Hits	438	Target Neighborhood Hits	241	Shared Neighborhood Hits	152
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

TRAF4_MOUSE
θ value	1.09739e-05 (rank : 84)	NC score	0.269754 (rank : 149)
Query Neighborhood Hits	438	Target Neighborhood Hits	338	Shared Neighborhood Hits	106
SwissProt Accessions	Q61382	Gene names	Traf4, Cart1
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1).

PDZ11_HUMAN
θ value	1.43324e-05 (rank : 85)	NC score	0.570259 (rank : 32)
Query Neighborhood Hits	438	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

TRI25_MOUSE
θ value	1.43324e-05 (rank : 86)	NC score	0.278467 (rank : 139)
Query Neighborhood Hits	438	Target Neighborhood Hits	446	Shared Neighborhood Hits	199
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

NEB2_HUMAN
θ value	1.87187e-05 (rank : 87)	NC score	0.357585 (rank : 99)
Query Neighborhood Hits	438	Target Neighborhood Hits	883	Shared Neighborhood Hits	164
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	1.87187e-05 (rank : 88)	NC score	0.353990 (rank : 100)
Query Neighborhood Hits	438	Target Neighborhood Hits	889	Shared Neighborhood Hits	165
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

RN166_HUMAN
θ value	2.44474e-05 (rank : 89)	NC score	0.344712 (rank : 104)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	162
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

TIAM1_HUMAN
θ value	2.44474e-05 (rank : 90)	NC score	0.104077 (rank : 376)
Query Neighborhood Hits	438	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

GRIP2_HUMAN
θ value	3.19293e-05 (rank : 91)	NC score	0.534429 (rank : 44)
Query Neighborhood Hits	438	Target Neighborhood Hits	256	Shared Neighborhood Hits	152
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

PEX10_HUMAN
θ value	3.19293e-05 (rank : 92)	NC score	0.348489 (rank : 102)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	176
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

RAG1_HUMAN
θ value	3.19293e-05 (rank : 93)	NC score	0.293992 (rank : 131)
Query Neighborhood Hits	438	Target Neighborhood Hits	203	Shared Neighborhood Hits	141
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

PDZ11_MOUSE
θ value	4.1701e-05 (rank : 94)	NC score	0.566719 (rank : 35)
Query Neighborhood Hits	438	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

DVL1_HUMAN
θ value	5.44631e-05 (rank : 95)	NC score	0.411301 (rank : 82)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	114
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

GOPC_HUMAN
θ value	5.44631e-05 (rank : 96)	NC score	0.526898 (rank : 46)
Query Neighborhood Hits	438	Target Neighborhood Hits	377	Shared Neighborhood Hits	159
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GOPC_MOUSE
θ value	5.44631e-05 (rank : 97)	NC score	0.533566 (rank : 45)
Query Neighborhood Hits	438	Target Neighborhood Hits	323	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

USH1C_MOUSE
θ value	5.44631e-05 (rank : 98)	NC score	0.540695 (rank : 43)
Query Neighborhood Hits	438	Target Neighborhood Hits	557	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

BRCA1_MOUSE
θ value	7.1131e-05 (rank : 99)	NC score	0.272698 (rank : 144)
Query Neighborhood Hits	438	Target Neighborhood Hits	436	Shared Neighborhood Hits	178
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

DVL1_MOUSE
θ value	7.1131e-05 (rank : 100)	NC score	0.407084 (rank : 84)
Query Neighborhood Hits	438	Target Neighborhood Hits	146	Shared Neighborhood Hits	111
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

TRI65_HUMAN
θ value	7.1131e-05 (rank : 101)	NC score	0.296181 (rank : 129)
Query Neighborhood Hits	438	Target Neighborhood Hits	330	Shared Neighborhood Hits	194
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

BRCA1_HUMAN
θ value	0.000121331 (rank : 102)	NC score	0.285490 (rank : 137)
Query Neighborhood Hits	438	Target Neighborhood Hits	381	Shared Neighborhood Hits	183
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

DVL1L_HUMAN
θ value	0.000121331 (rank : 103)	NC score	0.398028 (rank : 86)
Query Neighborhood Hits	438	Target Neighborhood Hits	146	Shared Neighborhood Hits	112
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL2_HUMAN
θ value	0.000121331 (rank : 104)	NC score	0.389462 (rank : 88)
Query Neighborhood Hits	438	Target Neighborhood Hits	223	Shared Neighborhood Hits	107
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	0.000121331 (rank : 105)	NC score	0.389264 (rank : 89)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	109
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

TRI68_MOUSE
θ value	0.000121331 (rank : 106)	NC score	0.221285 (rank : 206)
Query Neighborhood Hits	438	Target Neighborhood Hits	356	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

RAG1_MOUSE
θ value	0.000158464 (rank : 107)	NC score	0.287642 (rank : 134)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	143
SwissProt Accessions	P15919	Gene names	Rag1, Rag-1
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1).

TRI50_HUMAN
θ value	0.000158464 (rank : 108)	NC score	0.240412 (rank : 185)
Query Neighborhood Hits	438	Target Neighborhood Hits	294	Shared Neighborhood Hits	179
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

LAP2_HUMAN
θ value	0.00020696 (rank : 109)	NC score	0.234761 (rank : 189)
Query Neighborhood Hits	438	Target Neighborhood Hits	499	Shared Neighborhood Hits	113
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LAP2_MOUSE
θ value	0.00020696 (rank : 110)	NC score	0.225557 (rank : 200)
Query Neighborhood Hits	438	Target Neighborhood Hits	482	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

SNTG1_HUMAN
θ value	0.00020696 (rank : 111)	NC score	0.464681 (rank : 71)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

DVL3_HUMAN
θ value	0.000270298 (rank : 112)	NC score	0.407231 (rank : 83)
Query Neighborhood Hits	438	Target Neighborhood Hits	194	Shared Neighborhood Hits	112
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	0.000270298 (rank : 113)	NC score	0.406996 (rank : 85)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

SNTG1_MOUSE
θ value	0.000270298 (rank : 114)	NC score	0.462847 (rank : 73)
Query Neighborhood Hits	438	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

ZO2_HUMAN
θ value	0.000270298 (rank : 115)	NC score	0.453724 (rank : 75)
Query Neighborhood Hits	438	Target Neighborhood Hits	289	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

TRI26_HUMAN
θ value	0.00035302 (rank : 116)	NC score	0.258147 (rank : 157)
Query Neighborhood Hits	438	Target Neighborhood Hits	335	Shared Neighborhood Hits	194
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI68_HUMAN
θ value	0.00035302 (rank : 117)	NC score	0.216991 (rank : 214)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	166
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

NHRF2_HUMAN
θ value	0.000461057 (rank : 118)	NC score	0.478610 (rank : 67)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	140
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

TRI25_HUMAN
θ value	0.000461057 (rank : 119)	NC score	0.266246 (rank : 151)
Query Neighborhood Hits	438	Target Neighborhood Hits	472	Shared Neighborhood Hits	195
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI26_MOUSE
θ value	0.000461057 (rank : 120)	NC score	0.257102 (rank : 158)
Query Neighborhood Hits	438	Target Neighborhood Hits	339	Shared Neighborhood Hits	195
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

ZN364_HUMAN
θ value	0.000602161 (rank : 121)	NC score	0.171857 (rank : 282)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y4L5, Q5T2V9, Q7Z2J2	Gene names	ZNF364, RNF115
Domain Architecture	No domain graphic available
Description	Zinc finger protein 364 (Rabring 7) (RING finger protein 115).

ZO2_MOUSE
θ value	0.000602161 (rank : 122)	NC score	0.452322 (rank : 76)
Query Neighborhood Hits	438	Target Neighborhood Hits	296	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

TRIM6_HUMAN
θ value	0.000786445 (rank : 123)	NC score	0.224679 (rank : 202)
Query Neighborhood Hits	438	Target Neighborhood Hits	412	Shared Neighborhood Hits	180
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

PSCBP_HUMAN
θ value	0.00102713 (rank : 124)	NC score	0.284917 (rank : 138)
Query Neighborhood Hits	438	Target Neighborhood Hits	123	Shared Neighborhood Hits	95
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

STXB4_HUMAN
θ value	0.00102713 (rank : 125)	NC score	0.332965 (rank : 107)
Query Neighborhood Hits	438	Target Neighborhood Hits	616	Shared Neighborhood Hits	131
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TRI65_MOUSE
θ value	0.00102713 (rank : 126)	NC score	0.276378 (rank : 141)
Query Neighborhood Hits	438	Target Neighborhood Hits	340	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI73_HUMAN
θ value	0.00102713 (rank : 127)	NC score	0.256209 (rank : 159)
Query Neighborhood Hits	438	Target Neighborhood Hits	258	Shared Neighborhood Hits	170
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

BICD2_HUMAN
θ value	0.00134147 (rank : 128)	NC score	0.061960 (rank : 459)
Query Neighborhood Hits	438	Target Neighborhood Hits	856	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	0.00134147 (rank : 129)	NC score	0.060225 (rank : 465)
Query Neighborhood Hits	438	Target Neighborhood Hits	864	Shared Neighborhood Hits	69
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

K1849_HUMAN
θ value	0.00134147 (rank : 130)	NC score	0.419139 (rank : 79)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NHERF_HUMAN
θ value	0.00134147 (rank : 131)	NC score	0.464361 (rank : 72)
Query Neighborhood Hits	438	Target Neighborhood Hits	190	Shared Neighborhood Hits	130
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	0.00134147 (rank : 132)	NC score	0.477816 (rank : 68)
Query Neighborhood Hits	438	Target Neighborhood Hits	195	Shared Neighborhood Hits	132
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

TRI74_HUMAN
θ value	0.00134147 (rank : 133)	NC score	0.248792 (rank : 166)
Query Neighborhood Hits	438	Target Neighborhood Hits	249	Shared Neighborhood Hits	164
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

K1849_MOUSE
θ value	0.00175202 (rank : 134)	NC score	0.411418 (rank : 81)
Query Neighborhood Hits	438	Target Neighborhood Hits	335	Shared Neighborhood Hits	139
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

GOGA5_MOUSE
θ value	0.00228821 (rank : 135)	NC score	0.033831 (rank : 499)
Query Neighborhood Hits	438	Target Neighborhood Hits	1434	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

MPP4_HUMAN
θ value	0.00228821 (rank : 136)	NC score	0.339170 (rank : 106)
Query Neighborhood Hits	438	Target Neighborhood Hits	205	Shared Neighborhood Hits	127
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MPP4_MOUSE
θ value	0.00228821 (rank : 137)	NC score	0.301603 (rank : 123)
Query Neighborhood Hits	438	Target Neighborhood Hits	188	Shared Neighborhood Hits	107
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

RIMS1_HUMAN
θ value	0.00228821 (rank : 138)	NC score	0.192150 (rank : 245)
Query Neighborhood Hits	438	Target Neighborhood Hits	437	Shared Neighborhood Hits	117
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

TRIM7_MOUSE
θ value	0.00228821 (rank : 139)	NC score	0.213582 (rank : 217)
Query Neighborhood Hits	438	Target Neighborhood Hits	358	Shared Neighborhood Hits	173
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

PDZD1_HUMAN
θ value	0.00298849 (rank : 140)	NC score	0.472616 (rank : 70)
Query Neighborhood Hits	438	Target Neighborhood Hits	190	Shared Neighborhood Hits	133
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PSCBP_MOUSE
θ value	0.00298849 (rank : 141)	NC score	0.308782 (rank : 119)
Query Neighborhood Hits	438	Target Neighborhood Hits	118	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

TRI10_MOUSE
θ value	0.00390308 (rank : 142)	NC score	0.225257 (rank : 201)
Query Neighborhood Hits	438	Target Neighborhood Hits	285	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI60_MOUSE
θ value	0.00509761 (rank : 143)	NC score	0.217379 (rank : 211)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	156
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

ZN364_MOUSE
θ value	0.00509761 (rank : 144)	NC score	0.155995 (rank : 294)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D0C1, Q8R5A1, Q9D885	Gene names	Znf364, Zfp364
Domain Architecture
Description	Zinc finger protein 364 (Rabring 7).

NHRF2_MOUSE
θ value	0.00665767 (rank : 145)	NC score	0.458752 (rank : 74)
Query Neighborhood Hits	438	Target Neighborhood Hits	194	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

RNF8_HUMAN
θ value	0.00665767 (rank : 146)	NC score	0.250558 (rank : 164)
Query Neighborhood Hits	438	Target Neighborhood Hits	622	Shared Neighborhood Hits	211
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI10_HUMAN
θ value	0.00665767 (rank : 147)	NC score	0.229006 (rank : 197)
Query Neighborhood Hits	438	Target Neighborhood Hits	315	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

NIN_HUMAN
θ value	0.00869519 (rank : 148)	NC score	0.039505 (rank : 492)
Query Neighborhood Hits	438	Target Neighborhood Hits	1416	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

RNF8_MOUSE
θ value	0.00869519 (rank : 149)	NC score	0.259970 (rank : 154)
Query Neighborhood Hits	438	Target Neighborhood Hits	618	Shared Neighborhood Hits	214
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

STXB4_MOUSE
θ value	0.00869519 (rank : 150)	NC score	0.328195 (rank : 108)
Query Neighborhood Hits	438	Target Neighborhood Hits	629	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TRI47_HUMAN
θ value	0.00869519 (rank : 151)	NC score	0.252557 (rank : 162)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	167
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	0.00869519 (rank : 152)	NC score	0.251251 (rank : 163)
Query Neighborhood Hits	438	Target Neighborhood Hits	295	Shared Neighborhood Hits	166
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRIM6_MOUSE
θ value	0.00869519 (rank : 153)	NC score	0.218661 (rank : 209)
Query Neighborhood Hits	438	Target Neighborhood Hits	451	Shared Neighborhood Hits	184
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

BICD1_HUMAN
θ value	0.0113563 (rank : 154)	NC score	0.055096 (rank : 476)
Query Neighborhood Hits	438	Target Neighborhood Hits	844	Shared Neighborhood Hits	61
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

MPP3_MOUSE
θ value	0.0148317 (rank : 155)	NC score	0.322957 (rank : 112)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	116
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

R113B_HUMAN
θ value	0.0148317 (rank : 156)	NC score	0.212543 (rank : 218)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	126
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

RFWD2_HUMAN
θ value	0.0193708 (rank : 157)	NC score	0.177220 (rank : 271)
Query Neighborhood Hits	438	Target Neighborhood Hits	518	Shared Neighborhood Hits	181
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	0.0193708 (rank : 158)	NC score	0.177272 (rank : 270)
Query Neighborhood Hits	438	Target Neighborhood Hits	535	Shared Neighborhood Hits	182
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RPGF6_HUMAN
θ value	0.0193708 (rank : 159)	NC score	0.298770 (rank : 127)
Query Neighborhood Hits	438	Target Neighborhood Hits	266	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TRI30_MOUSE
θ value	0.0193708 (rank : 160)	NC score	0.231908 (rank : 193)
Query Neighborhood Hits	438	Target Neighborhood Hits	434	Shared Neighborhood Hits	189
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

BFAR_HUMAN
θ value	0.0252991 (rank : 161)	NC score	0.254409 (rank : 161)
Query Neighborhood Hits	438	Target Neighborhood Hits	222	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BICD1_MOUSE
θ value	0.0252991 (rank : 162)	NC score	0.055942 (rank : 474)
Query Neighborhood Hits	438	Target Neighborhood Hits	837	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

SIA1A_MOUSE
θ value	0.0252991 (rank : 163)	NC score	0.134464 (rank : 324)
Query Neighborhood Hits	438	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

TRI56_HUMAN
θ value	0.0252991 (rank : 164)	NC score	0.193220 (rank : 243)
Query Neighborhood Hits	438	Target Neighborhood Hits	339	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

APBA2_HUMAN
θ value	0.0330416 (rank : 165)	NC score	0.291832 (rank : 133)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	129
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.0330416 (rank : 166)	NC score	0.293420 (rank : 132)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

GOGB1_HUMAN
θ value	0.0330416 (rank : 167)	NC score	0.040923 (rank : 491)
Query Neighborhood Hits	438	Target Neighborhood Hits	2297	Shared Neighborhood Hits	145
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

MPP3_HUMAN
θ value	0.0330416 (rank : 168)	NC score	0.314386 (rank : 116)
Query Neighborhood Hits	438	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

SIAH1_HUMAN
θ value	0.0330416 (rank : 169)	NC score	0.133857 (rank : 325)
Query Neighborhood Hits	438	Target Neighborhood Hits	72	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

TRI50_MOUSE
θ value	0.0330416 (rank : 170)	NC score	0.232909 (rank : 192)
Query Neighborhood Hits	438	Target Neighborhood Hits	326	Shared Neighborhood Hits	190
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

ARHGC_MOUSE
θ value	0.0431538 (rank : 171)	NC score	0.229504 (rank : 196)
Query Neighborhood Hits	438	Target Neighborhood Hits	344	Shared Neighborhood Hits	126
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PCGF6_MOUSE
θ value	0.0431538 (rank : 172)	NC score	0.166603 (rank : 288)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	115
SwissProt Accessions	Q99NA9	Gene names	Pcgf6, Mblr, Rnf134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

PDLI2_MOUSE
θ value	0.0431538 (rank : 173)	NC score	0.241249 (rank : 184)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PDZD3_MOUSE
θ value	0.0431538 (rank : 174)	NC score	0.397384 (rank : 87)
Query Neighborhood Hits	438	Target Neighborhood Hits	171	Shared Neighborhood Hits	128
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

R113A_HUMAN
θ value	0.0431538 (rank : 175)	NC score	0.226854 (rank : 199)
Query Neighborhood Hits	438	Target Neighborhood Hits	177	Shared Neighborhood Hits	126
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

RN126_MOUSE
θ value	0.0431538 (rank : 176)	NC score	0.156785 (rank : 293)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	90
SwissProt Accessions	Q91YL2	Gene names	Rnf126
Domain Architecture	No domain graphic available
Description	RING finger protein 126.

SIA1B_MOUSE
θ value	0.0431538 (rank : 177)	NC score	0.130024 (rank : 334)
Query Neighborhood Hits	438	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

TRI22_HUMAN
θ value	0.0431538 (rank : 178)	NC score	0.231742 (rank : 194)
Query Neighborhood Hits	438	Target Neighborhood Hits	396	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI39_HUMAN
θ value	0.0431538 (rank : 179)	NC score	0.217384 (rank : 210)
Query Neighborhood Hits	438	Target Neighborhood Hits	693	Shared Neighborhood Hits	216
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	0.0431538 (rank : 180)	NC score	0.216996 (rank : 213)
Query Neighborhood Hits	438	Target Neighborhood Hits	691	Shared Neighborhood Hits	214
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI43_HUMAN
θ value	0.0431538 (rank : 181)	NC score	0.227706 (rank : 198)
Query Neighborhood Hits	438	Target Neighborhood Hits	341	Shared Neighborhood Hits	174
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI56_MOUSE
θ value	0.0431538 (rank : 182)	NC score	0.187964 (rank : 250)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	159
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

TRIM1_HUMAN
θ value	0.0431538 (rank : 183)	NC score	0.183711 (rank : 257)
Query Neighborhood Hits	438	Target Neighborhood Hits	345	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRIM1_MOUSE
θ value	0.0431538 (rank : 184)	NC score	0.182399 (rank : 262)
Query Neighborhood Hits	438	Target Neighborhood Hits	361	Shared Neighborhood Hits	170
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

TRIM4_HUMAN
θ value	0.0431538 (rank : 185)	NC score	0.233763 (rank : 191)
Query Neighborhood Hits	438	Target Neighborhood Hits	321	Shared Neighborhood Hits	181
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

CBLC_HUMAN
θ value	0.0563607 (rank : 186)	NC score	0.153349 (rank : 297)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	119
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

PCGF6_HUMAN
θ value	0.0563607 (rank : 187)	NC score	0.166877 (rank : 287)
Query Neighborhood Hits	438	Target Neighborhood Hits	178	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

RN141_HUMAN
θ value	0.0563607 (rank : 188)	NC score	0.197730 (rank : 237)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
θ value	0.0563607 (rank : 189)	NC score	0.197907 (rank : 236)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	145
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

TRI59_HUMAN
θ value	0.0563607 (rank : 190)	NC score	0.246180 (rank : 171)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	177
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI59_MOUSE
θ value	0.0563607 (rank : 191)	NC score	0.247243 (rank : 169)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	174
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

ARHGB_HUMAN
θ value	0.0736092 (rank : 192)	NC score	0.244753 (rank : 176)
Query Neighborhood Hits	438	Target Neighborhood Hits	375	Shared Neighborhood Hits	135
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

BFAR_MOUSE
θ value	0.0736092 (rank : 193)	NC score	0.250495 (rank : 165)
Query Neighborhood Hits	438	Target Neighborhood Hits	232	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CBLB_HUMAN
θ value	0.0736092 (rank : 194)	NC score	0.149295 (rank : 305)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	142
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	0.0736092 (rank : 195)	NC score	0.148304 (rank : 307)
Query Neighborhood Hits	438	Target Neighborhood Hits	277	Shared Neighborhood Hits	141
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBL_HUMAN
θ value	0.0736092 (rank : 196)	NC score	0.156852 (rank : 292)
Query Neighborhood Hits	438	Target Neighborhood Hits	353	Shared Neighborhood Hits	153
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.0736092 (rank : 197)	NC score	0.155786 (rank : 295)
Query Neighborhood Hits	438	Target Neighborhood Hits	426	Shared Neighborhood Hits	159
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

NEST_HUMAN
θ value	0.0736092 (rank : 198)	NC score	0.035004 (rank : 493)
Query Neighborhood Hits	438	Target Neighborhood Hits	1305	Shared Neighborhood Hits	82
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

RN185_HUMAN
θ value	0.0736092 (rank : 199)	NC score	0.260425 (rank : 153)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	157
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	0.0736092 (rank : 200)	NC score	0.259447 (rank : 156)
Query Neighborhood Hits	438	Target Neighborhood Hits	211	Shared Neighborhood Hits	155
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF5_HUMAN
θ value	0.0736092 (rank : 201)	NC score	0.247922 (rank : 167)
Query Neighborhood Hits	438	Target Neighborhood Hits	206	Shared Neighborhood Hits	155
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

TRIM9_HUMAN
θ value	0.0736092 (rank : 202)	NC score	0.177051 (rank : 272)
Query Neighborhood Hits	438	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TRIM9_MOUSE
θ value	0.0736092 (rank : 203)	NC score	0.177352 (rank : 268)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	137
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

ZN179_HUMAN
θ value	0.0736092 (rank : 204)	NC score	0.238558 (rank : 186)
Query Neighborhood Hits	438	Target Neighborhood Hits	178	Shared Neighborhood Hits	134
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

AMFR2_HUMAN
θ value	0.0961366 (rank : 205)	NC score	0.190995 (rank : 247)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

AMFR_MOUSE
θ value	0.0961366 (rank : 206)	NC score	0.185659 (rank : 253)
Query Neighborhood Hits	438	Target Neighborhood Hits	208	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

ARHGC_HUMAN
θ value	0.0961366 (rank : 207)	NC score	0.231037 (rank : 195)
Query Neighborhood Hits	438	Target Neighborhood Hits	351	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CHFR_HUMAN
θ value	0.0961366 (rank : 208)	NC score	0.236697 (rank : 188)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	159
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CHFR_MOUSE
θ value	0.0961366 (rank : 209)	NC score	0.242867 (rank : 179)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	162
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

EM55_MOUSE
θ value	0.0961366 (rank : 210)	NC score	0.286744 (rank : 135)
Query Neighborhood Hits	438	Target Neighborhood Hits	221	Shared Neighborhood Hits	109
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

PAR6G_HUMAN
θ value	0.0961366 (rank : 211)	NC score	0.321292 (rank : 113)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

RNF5_MOUSE
θ value	0.0961366 (rank : 212)	NC score	0.243449 (rank : 178)
Query Neighborhood Hits	438	Target Neighborhood Hits	206	Shared Neighborhood Hits	152
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RPGF2_HUMAN
θ value	0.0961366 (rank : 213)	NC score	0.259796 (rank : 155)
Query Neighborhood Hits	438	Target Neighborhood Hits	242	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

TIAM1_MOUSE
θ value	0.0961366 (rank : 214)	NC score	0.079507 (rank : 425)
Query Neighborhood Hits	438	Target Neighborhood Hits	205	Shared Neighborhood Hits	49
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TRI13_HUMAN
θ value	0.0961366 (rank : 215)	NC score	0.246634 (rank : 170)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	184
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI17_HUMAN
θ value	0.0961366 (rank : 216)	NC score	0.210358 (rank : 222)
Query Neighborhood Hits	438	Target Neighborhood Hits	318	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI18_HUMAN
θ value	0.0961366 (rank : 217)	NC score	0.181105 (rank : 265)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	161
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI18_MOUSE
θ value	0.0961366 (rank : 218)	NC score	0.183255 (rank : 259)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	159
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRI27_HUMAN
θ value	0.0961366 (rank : 219)	NC score	0.185174 (rank : 254)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	162
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

APBA1_HUMAN
θ value	0.125558 (rank : 220)	NC score	0.295750 (rank : 130)
Query Neighborhood Hits	438	Target Neighborhood Hits	325	Shared Neighborhood Hits	133
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

BARD1_MOUSE
θ value	0.125558 (rank : 221)	NC score	0.068993 (rank : 441)
Query Neighborhood Hits	438	Target Neighborhood Hits	411	Shared Neighborhood Hits	80
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

CENPB_MOUSE
θ value	0.125558 (rank : 222)	NC score	0.053060 (rank : 478)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

EM55_HUMAN
θ value	0.125558 (rank : 223)	NC score	0.285916 (rank : 136)
Query Neighborhood Hits	438	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

HTRA3_HUMAN
θ value	0.125558 (rank : 224)	NC score	0.117100 (rank : 355)
Query Neighborhood Hits	438	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA4_HUMAN
θ value	0.125558 (rank : 225)	NC score	0.082182 (rank : 423)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

MPP5_HUMAN
θ value	0.125558 (rank : 226)	NC score	0.323883 (rank : 110)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	124
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	0.125558 (rank : 227)	NC score	0.323059 (rank : 111)
Query Neighborhood Hits	438	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PAR6A_HUMAN
θ value	0.125558 (rank : 228)	NC score	0.300131 (rank : 126)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

PAR6A_MOUSE
θ value	0.125558 (rank : 229)	NC score	0.301062 (rank : 124)
Query Neighborhood Hits	438	Target Neighborhood Hits	115	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

RN146_HUMAN
θ value	0.125558 (rank : 230)	NC score	0.201574 (rank : 233)
Query Neighborhood Hits	438	Target Neighborhood Hits	162	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

RN146_MOUSE
θ value	0.125558 (rank : 231)	NC score	0.202354 (rank : 231)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	127
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

TRI15_HUMAN
θ value	0.125558 (rank : 232)	NC score	0.205752 (rank : 229)
Query Neighborhood Hits	438	Target Neighborhood Hits	395	Shared Neighborhood Hits	175
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI27_MOUSE
θ value	0.125558 (rank : 233)	NC score	0.183945 (rank : 256)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	160
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRIM5_HUMAN
θ value	0.125558 (rank : 234)	NC score	0.223570 (rank : 204)
Query Neighborhood Hits	438	Target Neighborhood Hits	424	Shared Neighborhood Hits	187
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

CENPB_HUMAN
θ value	0.163984 (rank : 235)	NC score	0.048775 (rank : 486)
Query Neighborhood Hits	438	Target Neighborhood Hits	133	Shared Neighborhood Hits	13
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

HTRA3_MOUSE
θ value	0.163984 (rank : 236)	NC score	0.116713 (rank : 357)
Query Neighborhood Hits	438	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

PDLI2_HUMAN
θ value	0.163984 (rank : 237)	NC score	0.269886 (rank : 148)
Query Neighborhood Hits	438	Target Neighborhood Hits	245	Shared Neighborhood Hits	102
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PTN3_HUMAN
θ value	0.163984 (rank : 238)	NC score	0.120332 (rank : 350)
Query Neighborhood Hits	438	Target Neighborhood Hits	258	Shared Neighborhood Hits	95
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

SIAH2_HUMAN
θ value	0.163984 (rank : 239)	NC score	0.159317 (rank : 290)
Query Neighborhood Hits	438	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	0.163984 (rank : 240)	NC score	0.158501 (rank : 291)
Query Neighborhood Hits	438	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

TRI31_HUMAN
θ value	0.163984 (rank : 241)	NC score	0.255225 (rank : 160)
Query Neighborhood Hits	438	Target Neighborhood Hits	299	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

BARD1_HUMAN
θ value	0.21417 (rank : 242)	NC score	0.067615 (rank : 443)
Query Neighborhood Hits	438	Target Neighborhood Hits	427	Shared Neighborhood Hits	92
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

CBLC_MOUSE
θ value	0.21417 (rank : 243)	NC score	0.153193 (rank : 298)
Query Neighborhood Hits	438	Target Neighborhood Hits	186	Shared Neighborhood Hits	126
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

RN126_HUMAN
θ value	0.21417 (rank : 244)	NC score	0.149561 (rank : 304)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BV68, Q9NWX1	Gene names	RNF126
Domain Architecture	No domain graphic available
Description	RING finger protein 126.

RNF39_HUMAN
θ value	0.21417 (rank : 245)	NC score	0.190505 (rank : 248)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

SDCB1_HUMAN
θ value	0.21417 (rank : 246)	NC score	0.308084 (rank : 120)
Query Neighborhood Hits	438	Target Neighborhood Hits	150	Shared Neighborhood Hits	127
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.21417 (rank : 247)	NC score	0.309179 (rank : 118)
Query Neighborhood Hits	438	Target Neighborhood Hits	144	Shared Neighborhood Hits	120
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SEPT7_HUMAN
θ value	0.21417 (rank : 248)	NC score	0.023726 (rank : 523)
Query Neighborhood Hits	438	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q16181, Q6NX50	Gene names	SEPT7, CDC10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

SEPT7_MOUSE
θ value	0.21417 (rank : 249)	NC score	0.024292 (rank : 520)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	36
SwissProt Accessions	O55131	Gene names	Sept7, Cdc10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

TRI13_MOUSE
θ value	0.21417 (rank : 250)	NC score	0.247553 (rank : 168)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	186
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRIM8_HUMAN
θ value	0.21417 (rank : 251)	NC score	0.242143 (rank : 183)
Query Neighborhood Hits	438	Target Neighborhood Hits	650	Shared Neighborhood Hits	184
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	0.21417 (rank : 252)	NC score	0.242273 (rank : 182)
Query Neighborhood Hits	438	Target Neighborhood Hits	674	Shared Neighborhood Hits	181
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

CI039_HUMAN
θ value	0.279714 (rank : 253)	NC score	0.031590 (rank : 503)
Query Neighborhood Hits	438	Target Neighborhood Hits	1171	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CM007_MOUSE
θ value	0.279714 (rank : 254)	NC score	0.187949 (rank : 251)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	158
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

PAR6G_MOUSE
θ value	0.279714 (rank : 255)	NC score	0.318430 (rank : 115)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

PCLO_MOUSE
θ value	0.279714 (rank : 256)	NC score	0.138389 (rank : 318)
Query Neighborhood Hits	438	Target Neighborhood Hits	2275	Shared Neighborhood Hits	157
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDZD3_HUMAN
θ value	0.279714 (rank : 257)	NC score	0.415273 (rank : 80)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	131
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PTN4_HUMAN
θ value	0.279714 (rank : 258)	NC score	0.125284 (rank : 342)
Query Neighborhood Hits	438	Target Neighborhood Hits	303	Shared Neighborhood Hits	99
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

TRI35_MOUSE
θ value	0.279714 (rank : 259)	NC score	0.234533 (rank : 190)
Query Neighborhood Hits	438	Target Neighborhood Hits	465	Shared Neighborhood Hits	187
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI37_HUMAN
θ value	0.279714 (rank : 260)	NC score	0.172530 (rank : 281)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	140
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	0.279714 (rank : 261)	NC score	0.172708 (rank : 280)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI40_HUMAN
θ value	0.279714 (rank : 262)	NC score	0.265248 (rank : 152)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	169
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI60_HUMAN
θ value	0.279714 (rank : 263)	NC score	0.219692 (rank : 208)
Query Neighborhood Hits	438	Target Neighborhood Hits	357	Shared Neighborhood Hits	184
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

LEO1_MOUSE
θ value	0.365318 (rank : 264)	NC score	0.019816 (rank : 525)
Query Neighborhood Hits	438	Target Neighborhood Hits	946	Shared Neighborhood Hits	44
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PAR6B_HUMAN
θ value	0.365318 (rank : 265)	NC score	0.320915 (rank : 114)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

SDCB2_MOUSE
θ value	0.365318 (rank : 266)	NC score	0.270884 (rank : 147)
Query Neighborhood Hits	438	Target Neighborhood Hits	118	Shared Neighborhood Hits	99
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

TRI11_HUMAN
θ value	0.365318 (rank : 267)	NC score	0.211653 (rank : 219)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	174
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI34_HUMAN
θ value	0.365318 (rank : 268)	NC score	0.209226 (rank : 226)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRIM7_HUMAN
θ value	0.365318 (rank : 269)	NC score	0.209218 (rank : 227)
Query Neighborhood Hits	438	Target Neighborhood Hits	336	Shared Neighborhood Hits	173
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TXLNG_HUMAN
θ value	0.365318 (rank : 270)	NC score	0.033936 (rank : 497)
Query Neighborhood Hits	438	Target Neighborhood Hits	568	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

AFAD_HUMAN
θ value	0.47712 (rank : 271)	NC score	0.362158 (rank : 97)
Query Neighborhood Hits	438	Target Neighborhood Hits	689	Shared Neighborhood Hits	160
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

BRE1A_HUMAN
θ value	0.47712 (rank : 272)	NC score	0.083762 (rank : 419)
Query Neighborhood Hits	438	Target Neighborhood Hits	1071	Shared Neighborhood Hits	170
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
θ value	0.47712 (rank : 273)	NC score	0.085664 (rank : 416)
Query Neighborhood Hits	438	Target Neighborhood Hits	1025	Shared Neighborhood Hits	165
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CM007_HUMAN
θ value	0.47712 (rank : 274)	NC score	0.171324 (rank : 283)
Query Neighborhood Hits	438	Target Neighborhood Hits	422	Shared Neighborhood Hits	154
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

DSPP_HUMAN
θ value	0.47712 (rank : 275)	NC score	0.044301 (rank : 489)
Query Neighborhood Hits	438	Target Neighborhood Hits	645	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

RAD18_HUMAN
θ value	0.47712 (rank : 276)	NC score	0.175557 (rank : 273)
Query Neighborhood Hits	438	Target Neighborhood Hits	284	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

RN168_HUMAN
θ value	0.47712 (rank : 277)	NC score	0.244994 (rank : 174)
Query Neighborhood Hits	438	Target Neighborhood Hits	370	Shared Neighborhood Hits	158
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI62_HUMAN
θ value	0.47712 (rank : 278)	NC score	0.205959 (rank : 228)
Query Neighborhood Hits	438	Target Neighborhood Hits	584	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_MOUSE
θ value	0.47712 (rank : 279)	NC score	0.211599 (rank : 220)
Query Neighborhood Hits	438	Target Neighborhood Hits	478	Shared Neighborhood Hits	187
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

CF060_HUMAN
θ value	0.62314 (rank : 280)	NC score	0.033872 (rank : 498)
Query Neighborhood Hits	438	Target Neighborhood Hits	1270	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CNKR2_HUMAN
θ value	0.62314 (rank : 281)	NC score	0.103443 (rank : 378)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.62314 (rank : 282)	NC score	0.103474 (rank : 377)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

DZIP3_HUMAN
θ value	0.62314 (rank : 283)	NC score	0.118109 (rank : 354)
Query Neighborhood Hits	438	Target Neighborhood Hits	399	Shared Neighborhood Hits	94
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

GORS2_HUMAN
θ value	0.62314 (rank : 284)	NC score	0.031253 (rank : 504)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

GORS2_MOUSE
θ value	0.62314 (rank : 285)	NC score	0.029535 (rank : 509)
Query Neighborhood Hits	438	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

KNTC2_HUMAN
θ value	0.62314 (rank : 286)	NC score	0.034093 (rank : 495)
Query Neighborhood Hits	438	Target Neighborhood Hits	673	Shared Neighborhood Hits	58
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

PAR6B_MOUSE
θ value	0.62314 (rank : 287)	NC score	0.323961 (rank : 109)
Query Neighborhood Hits	438	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

RN168_MOUSE
θ value	0.62314 (rank : 288)	NC score	0.244782 (rank : 175)
Query Neighborhood Hits	438	Target Neighborhood Hits	440	Shared Neighborhood Hits	173
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SMRA3_HUMAN
θ value	0.62314 (rank : 289)	NC score	0.149870 (rank : 302)
Query Neighborhood Hits	438	Target Neighborhood Hits	265	Shared Neighborhood Hits	164
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

BRE1B_HUMAN
θ value	0.813845 (rank : 290)	NC score	0.081401 (rank : 424)
Query Neighborhood Hits	438	Target Neighborhood Hits	1040	Shared Neighborhood Hits	165
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	0.813845 (rank : 291)	NC score	0.082576 (rank : 421)
Query Neighborhood Hits	438	Target Neighborhood Hits	970	Shared Neighborhood Hits	162
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

NHLC1_MOUSE
θ value	0.813845 (rank : 292)	NC score	0.115019 (rank : 358)
Query Neighborhood Hits	438	Target Neighborhood Hits	103	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

NPAS3_HUMAN
θ value	0.813845 (rank : 293)	NC score	0.012703 (rank : 538)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

TRI35_HUMAN
θ value	0.813845 (rank : 294)	NC score	0.238161 (rank : 187)
Query Neighborhood Hits	438	Target Neighborhood Hits	382	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

ARD1_HUMAN
θ value	1.06291 (rank : 295)	NC score	0.041556 (rank : 490)
Query Neighborhood Hits	438	Target Neighborhood Hits	621	Shared Neighborhood Hits	69
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

ARD1_MOUSE
θ value	1.06291 (rank : 296)	NC score	0.044780 (rank : 488)
Query Neighborhood Hits	438	Target Neighborhood Hits	573	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

HTRA1_HUMAN
θ value	1.06291 (rank : 297)	NC score	0.078354 (rank : 427)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

PCGF2_HUMAN
θ value	1.06291 (rank : 298)	NC score	0.130458 (rank : 331)
Query Neighborhood Hits	438	Target Neighborhood Hits	222	Shared Neighborhood Hits	118
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCGF2_MOUSE
θ value	1.06291 (rank : 299)	NC score	0.130409 (rank : 332)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	114
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

RAD18_MOUSE
θ value	1.06291 (rank : 300)	NC score	0.182170 (rank : 263)
Query Neighborhood Hits	438	Target Neighborhood Hits	230	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

RN103_HUMAN
θ value	1.06291 (rank : 301)	NC score	0.097926 (rank : 384)
Query Neighborhood Hits	438	Target Neighborhood Hits	153	Shared Neighborhood Hits	80
SwissProt Accessions	O00237, Q8IVB9	Gene names	RNF103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103 homolog) (Zfp-103) (KF-1) (hKF-1).

RN103_MOUSE
θ value	1.06291 (rank : 302)	NC score	0.100907 (rank : 382)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1W3, O08670, O08883	Gene names	Rnf103, Zfp103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103) (Zfp-103) (KF-1) (mKF-1).

RO52_MOUSE
θ value	1.06291 (rank : 303)	NC score	0.209524 (rank : 223)
Query Neighborhood Hits	438	Target Neighborhood Hits	360	Shared Neighborhood Hits	181
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

SMRA3_MOUSE
θ value	1.06291 (rank : 304)	NC score	0.148294 (rank : 308)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	163
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

TRAF2_HUMAN
θ value	1.06291 (rank : 305)	NC score	0.195943 (rank : 238)
Query Neighborhood Hits	438	Target Neighborhood Hits	402	Shared Neighborhood Hits	119
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

TRI12_MOUSE
θ value	1.06291 (rank : 306)	NC score	0.242507 (rank : 180)
Query Neighborhood Hits	438	Target Neighborhood Hits	387	Shared Neighborhood Hits	175
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

APBA3_MOUSE
θ value	1.38821 (rank : 307)	NC score	0.266308 (rank : 150)
Query Neighborhood Hits	438	Target Neighborhood Hits	174	Shared Neighborhood Hits	111
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

DZIP3_MOUSE
θ value	1.38821 (rank : 308)	NC score	0.114253 (rank : 361)
Query Neighborhood Hits	438	Target Neighborhood Hits	414	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

GRASP_HUMAN
θ value	1.38821 (rank : 309)	NC score	0.274616 (rank : 143)
Query Neighborhood Hits	438	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

MGRN1_MOUSE
θ value	1.38821 (rank : 310)	NC score	0.090351 (rank : 411)
Query Neighborhood Hits	438	Target Neighborhood Hits	149	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

TRAF2_MOUSE
θ value	1.38821 (rank : 311)	NC score	0.199453 (rank : 235)
Query Neighborhood Hits	438	Target Neighborhood Hits	394	Shared Neighborhood Hits	125
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

TRI11_MOUSE
θ value	1.38821 (rank : 312)	NC score	0.210581 (rank : 221)
Query Neighborhood Hits	438	Target Neighborhood Hits	329	Shared Neighborhood Hits	171
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI17_MOUSE
θ value	1.38821 (rank : 313)	NC score	0.192844 (rank : 244)
Query Neighborhood Hits	438	Target Neighborhood Hits	620	Shared Neighborhood Hits	181
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

HGS_MOUSE
θ value	1.81305 (rank : 314)	NC score	0.015831 (rank : 530)
Query Neighborhood Hits	438	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HIP1R_HUMAN
θ value	1.81305 (rank : 315)	NC score	0.027984 (rank : 513)
Query Neighborhood Hits	438	Target Neighborhood Hits	809	Shared Neighborhood Hits	58
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

MGRN1_HUMAN
θ value	1.81305 (rank : 316)	NC score	0.091783 (rank : 404)
Query Neighborhood Hits	438	Target Neighborhood Hits	192	Shared Neighborhood Hits	97
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MRCKB_HUMAN
θ value	1.81305 (rank : 317)	NC score	0.006001 (rank : 552)
Query Neighborhood Hits	438	Target Neighborhood Hits	2239	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PICK1_MOUSE
θ value	1.81305 (rank : 318)	NC score	0.305184 (rank : 121)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

RC3H1_HUMAN
θ value	1.81305 (rank : 319)	NC score	0.094526 (rank : 396)
Query Neighborhood Hits	438	Target Neighborhood Hits	433	Shared Neighborhood Hits	124
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RC3H1_MOUSE
θ value	1.81305 (rank : 320)	NC score	0.095871 (rank : 391)
Query Neighborhood Hits	438	Target Neighborhood Hits	244	Shared Neighborhood Hits	115
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

TRI32_HUMAN
θ value	1.81305 (rank : 321)	NC score	0.173271 (rank : 279)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	144
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	1.81305 (rank : 322)	NC score	0.173316 (rank : 278)
Query Neighborhood Hits	438	Target Neighborhood Hits	271	Shared Neighborhood Hits	144
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

MAST1_MOUSE
θ value	2.36792 (rank : 323)	NC score	0.025549 (rank : 516)
Query Neighborhood Hits	438	Target Neighborhood Hits	1123	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PCGF4_HUMAN
θ value	2.36792 (rank : 324)	NC score	0.121981 (rank : 346)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	118
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

PCGF4_MOUSE
θ value	2.36792 (rank : 325)	NC score	0.121820 (rank : 347)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	116
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

RN183_HUMAN
θ value	2.36792 (rank : 326)	NC score	0.128060 (rank : 337)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	89
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RN183_MOUSE
θ value	2.36792 (rank : 327)	NC score	0.116960 (rank : 356)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	85
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RNF24_HUMAN
θ value	2.36792 (rank : 328)	NC score	0.082888 (rank : 420)
Query Neighborhood Hits	438	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y225, Q9UMH1	Gene names	RNF24
Domain Architecture
Description	RING finger protein 24.

RNF37_HUMAN
θ value	2.36792 (rank : 329)	NC score	0.050836 (rank : 484)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	O94941	Gene names	UBOX5, KIAA0860, RNF37, UBCE7IP5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (U-box domain-containing protein 5).

SCF_HUMAN
θ value	2.36792 (rank : 330)	NC score	0.024648 (rank : 518)
Query Neighborhood Hits	438	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P21583, Q16487, Q9UQK7	Gene names	KITLG, MGF, SCF
Domain Architecture
Description	Kit ligand precursor (C-kit ligand) (Stem cell factor) (SCF) (Mast cell growth factor) (MGF).

SCF_MOUSE
θ value	2.36792 (rank : 331)	NC score	0.024691 (rank : 517)
Query Neighborhood Hits	438	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	P20826, P97332, Q3TNJ7, Q62524, Q64222, Q921N5	Gene names	Kitlg, Kitl, Mgf, Sl, Slf
Domain Architecture
Description	Kit ligand precursor (C-kit ligand) (Stem cell factor) (SCF) (Mast cell growth factor) (MGF) (Hematopoietic growth factor KL) (Steel factor).

STK10_MOUSE
θ value	2.36792 (rank : 332)	NC score	0.000395 (rank : 560)
Query Neighborhood Hits	438	Target Neighborhood Hits	2132	Shared Neighborhood Hits	92
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

UHRF1_HUMAN
θ value	2.36792 (rank : 333)	NC score	0.121413 (rank : 348)
Query Neighborhood Hits	438	Target Neighborhood Hits	272	Shared Neighborhood Hits	142
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

ZN638_MOUSE
θ value	2.36792 (rank : 334)	NC score	0.012803 (rank : 537)
Query Neighborhood Hits	438	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

AKAP9_HUMAN
θ value	3.0926 (rank : 335)	NC score	0.033283 (rank : 500)
Query Neighborhood Hits	438	Target Neighborhood Hits	1710	Shared Neighborhood Hits	99
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ANKY2_MOUSE
θ value	3.0926 (rank : 336)	NC score	0.002670 (rank : 559)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

CJ078_MOUSE
θ value	3.0926 (rank : 337)	NC score	0.019575 (rank : 526)
Query Neighborhood Hits	438	Target Neighborhood Hits	559	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

GRASP_MOUSE
θ value	3.0926 (rank : 338)	NC score	0.271116 (rank : 146)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

HTRA1_MOUSE
θ value	3.0926 (rank : 339)	NC score	0.075669 (rank : 434)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

KPCZ_HUMAN
θ value	3.0926 (rank : 340)	NC score	-0.007338 (rank : 567)
Query Neighborhood Hits	438	Target Neighborhood Hits	884	Shared Neighborhood Hits	14
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MAST1_HUMAN
θ value	3.0926 (rank : 341)	NC score	0.023991 (rank : 522)
Query Neighborhood Hits	438	Target Neighborhood Hits	1146	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MRCKB_MOUSE
θ value	3.0926 (rank : 342)	NC score	0.008016 (rank : 547)
Query Neighborhood Hits	438	Target Neighborhood Hits	2180	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PPIP2_HUMAN
θ value	3.0926 (rank : 343)	NC score	0.018489 (rank : 528)
Query Neighborhood Hits	438	Target Neighborhood Hits	254	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

RN167_HUMAN
θ value	3.0926 (rank : 344)	NC score	0.086648 (rank : 415)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H6Y7, Q6XYE0, Q8NDC1, Q9Y3V1	Gene names	RNF167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

RN167_MOUSE
θ value	3.0926 (rank : 345)	NC score	0.091085 (rank : 406)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q91XF4, Q3U4S5	Gene names	Rnf167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

RNF24_MOUSE
θ value	3.0926 (rank : 346)	NC score	0.082289 (rank : 422)
Query Neighborhood Hits	438	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

RNF37_MOUSE
θ value	3.0926 (rank : 347)	NC score	0.060022 (rank : 466)
Query Neighborhood Hits	438	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

SPTB1_MOUSE
θ value	3.0926 (rank : 348)	NC score	0.011077 (rank : 540)
Query Neighborhood Hits	438	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

CENPF_HUMAN
θ value	4.03905 (rank : 349)	NC score	0.034358 (rank : 494)
Query Neighborhood Hits	438	Target Neighborhood Hits	1932	Shared Neighborhood Hits	119
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

ESCO2_HUMAN
θ value	4.03905 (rank : 350)	NC score	0.009631 (rank : 544)
Query Neighborhood Hits	438	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q56NI9	Gene names	ESCO2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

HGS_HUMAN
θ value	4.03905 (rank : 351)	NC score	0.013443 (rank : 536)
Query Neighborhood Hits	438	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

I18RA_HUMAN
θ value	4.03905 (rank : 352)	NC score	0.004627 (rank : 554)
Query Neighborhood Hits	438	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

NALP4_HUMAN
θ value	4.03905 (rank : 353)	NC score	0.011752 (rank : 539)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NHLC1_HUMAN
θ value	4.03905 (rank : 354)	NC score	0.086819 (rank : 414)
Query Neighborhood Hits	438	Target Neighborhood Hits	91	Shared Neighborhood Hits	69
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

NPAS3_MOUSE
θ value	4.03905 (rank : 355)	NC score	0.013794 (rank : 535)
Query Neighborhood Hits	438	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NSBP1_MOUSE
θ value	4.03905 (rank : 356)	NC score	0.015515 (rank : 531)
Query Neighborhood Hits	438	Target Neighborhood Hits	681	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

PICK1_HUMAN
θ value	4.03905 (rank : 357)	NC score	0.300857 (rank : 125)
Query Neighborhood Hits	438	Target Neighborhood Hits	132	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

REST_HUMAN
θ value	4.03905 (rank : 358)	NC score	0.029057 (rank : 510)
Query Neighborhood Hits	438	Target Neighborhood Hits	1605	Shared Neighborhood Hits	101
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SDCB2_HUMAN
θ value	4.03905 (rank : 359)	NC score	0.246005 (rank : 173)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	99
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SDK2_MOUSE
θ value	4.03905 (rank : 360)	NC score	-0.003634 (rank : 562)
Query Neighborhood Hits	438	Target Neighborhood Hits	480	Shared Neighborhood Hits	11
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SMCA1_HUMAN
θ value	4.03905 (rank : 361)	NC score	0.003798 (rank : 557)
Query Neighborhood Hits	438	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	P28370, Q5JV41, Q5JV42	Gene names	SMARCA1, SNF2L, SNF2L1
Domain Architecture
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1).

SPEG_MOUSE
θ value	4.03905 (rank : 362)	NC score	-0.004145 (rank : 563)
Query Neighborhood Hits	438	Target Neighborhood Hits	1959	Shared Neighborhood Hits	40
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SUHW4_HUMAN
θ value	4.03905 (rank : 363)	NC score	-0.005272 (rank : 565)
Query Neighborhood Hits	438	Target Neighborhood Hits	860	Shared Neighborhood Hits	22
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

TRI46_HUMAN
θ value	4.03905 (rank : 364)	NC score	0.148008 (rank : 309)
Query Neighborhood Hits	438	Target Neighborhood Hits	291	Shared Neighborhood Hits	137
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	4.03905 (rank : 365)	NC score	0.147895 (rank : 310)
Query Neighborhood Hits	438	Target Neighborhood Hits	287	Shared Neighborhood Hits	135
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

AIRE_MOUSE
θ value	5.27518 (rank : 366)	NC score	0.006294 (rank : 551)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

CD2L2_HUMAN
θ value	5.27518 (rank : 367)	NC score	-0.004530 (rank : 564)
Query Neighborhood Hits	438	Target Neighborhood Hits	1439	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

DIDO1_HUMAN
θ value	5.27518 (rank : 368)	NC score	0.004239 (rank : 555)
Query Neighborhood Hits	438	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GOLI_HUMAN
θ value	5.27518 (rank : 369)	NC score	0.093700 (rank : 398)
Query Neighborhood Hits	438	Target Neighborhood Hits	137	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

GOLI_MOUSE
θ value	5.27518 (rank : 370)	NC score	0.094971 (rank : 393)
Query Neighborhood Hits	438	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

GON4L_HUMAN
θ value	5.27518 (rank : 371)	NC score	0.009826 (rank : 543)
Query Neighborhood Hits	438	Target Neighborhood Hits	555	Shared Neighborhood Hits	29
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HDAC6_MOUSE
θ value	5.27518 (rank : 372)	NC score	0.003178 (rank : 558)
Query Neighborhood Hits	438	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

MACOI_MOUSE
θ value	5.27518 (rank : 373)	NC score	0.032528 (rank : 501)
Query Neighborhood Hits	438	Target Neighborhood Hits	620	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

NALP5_MOUSE
θ value	5.27518 (rank : 374)	NC score	0.007171 (rank : 549)
Query Neighborhood Hits	438	Target Neighborhood Hits	560	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

RB6I2_HUMAN
θ value	5.27518 (rank : 375)	NC score	0.030157 (rank : 507)
Query Neighborhood Hits	438	Target Neighborhood Hits	1584	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RN122_HUMAN
θ value	5.27518 (rank : 376)	NC score	0.076860 (rank : 431)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H9V4, Q52LK3	Gene names	RNF122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

RN122_MOUSE
θ value	5.27518 (rank : 377)	NC score	0.077670 (rank : 428)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BP31, Q80VA7, Q8BGD3	Gene names	Rnf122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

RO52_HUMAN
θ value	5.27518 (rank : 378)	NC score	0.209390 (rank : 224)
Query Neighborhood Hits	438	Target Neighborhood Hits	419	Shared Neighborhood Hits	201
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

RPGR_HUMAN
θ value	5.27518 (rank : 379)	NC score	0.008049 (rank : 546)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RUFY1_HUMAN
θ value	5.27518 (rank : 380)	NC score	0.024471 (rank : 519)
Query Neighborhood Hits	438	Target Neighborhood Hits	848	Shared Neighborhood Hits	69
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SPEG_HUMAN
θ value	5.27518 (rank : 381)	NC score	-0.007615 (rank : 568)
Query Neighborhood Hits	438	Target Neighborhood Hits	1762	Shared Neighborhood Hits	29
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPG16_HUMAN
θ value	5.27518 (rank : 382)	NC score	0.005661 (rank : 553)
Query Neighborhood Hits	438	Target Neighborhood Hits	361	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

TOPRS_HUMAN
θ value	5.27518 (rank : 383)	NC score	0.134627 (rank : 323)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	130
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TOPRS_MOUSE
θ value	5.27518 (rank : 384)	NC score	0.135304 (rank : 322)
Query Neighborhood Hits	438	Target Neighborhood Hits	263	Shared Neighborhood Hits	127
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TRI49_HUMAN
θ value	5.27518 (rank : 385)	NC score	0.194258 (rank : 240)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

UHRF1_MOUSE
θ value	5.27518 (rank : 386)	NC score	0.110697 (rank : 370)
Query Neighborhood Hits	438	Target Neighborhood Hits	278	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

ANR25_HUMAN
θ value	6.88961 (rank : 387)	NC score	0.000104 (rank : 561)
Query Neighborhood Hits	438	Target Neighborhood Hits	350	Shared Neighborhood Hits	8
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

APBA3_HUMAN
θ value	6.88961 (rank : 388)	NC score	0.271285 (rank : 145)
Query Neighborhood Hits	438	Target Neighborhood Hits	201	Shared Neighborhood Hits	114
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

BIRC2_HUMAN
θ value	6.88961 (rank : 389)	NC score	0.033961 (rank : 496)
Query Neighborhood Hits	438	Target Neighborhood Hits	142	Shared Neighborhood Hits	78
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

CCD46_MOUSE
θ value	6.88961 (rank : 390)	NC score	0.028585 (rank : 512)
Query Neighborhood Hits	438	Target Neighborhood Hits	1405	Shared Neighborhood Hits	97
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CF122_HUMAN
θ value	6.88961 (rank : 391)	NC score	0.014514 (rank : 533)
Query Neighborhood Hits	438	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T6M2, Q96N37	Gene names	C6orf122
Domain Architecture	No domain graphic available
Description	Protein C6orf122.

CING_HUMAN
θ value	6.88961 (rank : 392)	NC score	0.026443 (rank : 514)
Query Neighborhood Hits	438	Target Neighborhood Hits	1275	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CSKP_HUMAN
θ value	6.88961 (rank : 393)	NC score	0.078562 (rank : 426)
Query Neighborhood Hits	438	Target Neighborhood Hits	1022	Shared Neighborhood Hits	110
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	6.88961 (rank : 394)	NC score	0.077249 (rank : 429)
Query Neighborhood Hits	438	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EEA1_HUMAN
θ value	6.88961 (rank : 395)	NC score	0.030495 (rank : 506)
Query Neighborhood Hits	438	Target Neighborhood Hits	1796	Shared Neighborhood Hits	116
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

GOGA5_HUMAN
θ value	6.88961 (rank : 396)	NC score	0.030782 (rank : 505)
Query Neighborhood Hits	438	Target Neighborhood Hits	1168	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

HN1L_MOUSE
θ value	6.88961 (rank : 397)	NC score	0.008750 (rank : 545)
Query Neighborhood Hits	438	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGH2	Gene names	D17Ertd441e
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

HOME2_MOUSE
θ value	6.88961 (rank : 398)	NC score	0.022431 (rank : 524)
Query Neighborhood Hits	438	Target Neighborhood Hits	882	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

K1914_HUMAN
θ value	6.88961 (rank : 399)	NC score	0.015107 (rank : 532)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

MLL2_HUMAN
θ value	6.88961 (rank : 400)	NC score	0.014333 (rank : 534)
Query Neighborhood Hits	438	Target Neighborhood Hits	1788	Shared Neighborhood Hits	87
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PLK2_HUMAN
θ value	6.88961 (rank : 401)	NC score	-0.006946 (rank : 566)
Query Neighborhood Hits	438	Target Neighborhood Hits	854	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PRAX_MOUSE
θ value	6.88961 (rank : 402)	NC score	0.091250 (rank : 405)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	40
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

RB6I2_MOUSE
θ value	6.88961 (rank : 403)	NC score	0.029666 (rank : 508)
Query Neighborhood Hits	438	Target Neighborhood Hits	1433	Shared Neighborhood Hits	92
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RNF13_MOUSE
θ value	6.88961 (rank : 404)	NC score	0.072438 (rank : 438)
Query Neighborhood Hits	438	Target Neighborhood Hits	164	Shared Neighborhood Hits	77
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

TRI36_HUMAN
θ value	6.88961 (rank : 405)	NC score	0.130492 (rank : 330)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

TRI36_MOUSE
θ value	6.88961 (rank : 406)	NC score	0.127742 (rank : 338)
Query Neighborhood Hits	438	Target Neighborhood Hits	266	Shared Neighborhood Hits	129
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

TRI48_HUMAN
θ value	6.88961 (rank : 407)	NC score	0.199788 (rank : 234)
Query Neighborhood Hits	438	Target Neighborhood Hits	192	Shared Neighborhood Hits	139
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI52_HUMAN
θ value	6.88961 (rank : 408)	NC score	0.246176 (rank : 172)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	154
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TTL12_HUMAN
θ value	6.88961 (rank : 409)	NC score	0.010926 (rank : 542)
Query Neighborhood Hits	438	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q14166, Q9UGU3	Gene names	TTLL12, KIAA0153
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 12.

C8AP2_HUMAN
θ value	8.99809 (rank : 410)	NC score	0.010935 (rank : 541)
Query Neighborhood Hits	438	Target Neighborhood Hits	548	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CA082_MOUSE
θ value	8.99809 (rank : 411)	NC score	0.007364 (rank : 548)
Query Neighborhood Hits	438	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC34, Q3TLC8, Q3TSP8, Q3UKX0, Q8C7M5, Q8CBW8	Gene names
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82 homolog.

CING_MOUSE
θ value	8.99809 (rank : 412)	NC score	0.023997 (rank : 521)
Query Neighborhood Hits	438	Target Neighborhood Hits	1432	Shared Neighborhood Hits	92
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

FES_HUMAN
θ value	8.99809 (rank : 413)	NC score	-0.009588 (rank : 569)
Query Neighborhood Hits	438	Target Neighborhood Hits	978	Shared Neighborhood Hits	24
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LEO1_HUMAN
θ value	8.99809 (rank : 414)	NC score	0.017305 (rank : 529)
Query Neighborhood Hits	438	Target Neighborhood Hits	958	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MACOI_HUMAN
θ value	8.99809 (rank : 415)	NC score	0.028841 (rank : 511)
Query Neighborhood Hits	438	Target Neighborhood Hits	650	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MIB1_MOUSE
θ value	8.99809 (rank : 416)	NC score	0.026188 (rank : 515)
Query Neighborhood Hits	438	Target Neighborhood Hits	471	Shared Neighborhood Hits	83
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MYH9_HUMAN
θ value	8.99809 (rank : 417)	NC score	0.018736 (rank : 527)
Query Neighborhood Hits	438	Target Neighborhood Hits	1762	Shared Neighborhood Hits	112
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PEX2_MOUSE
θ value	8.99809 (rank : 418)	NC score	0.045977 (rank : 487)
Query Neighborhood Hits	438	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	P55098, O35467	Gene names	Pxmp3, Paf1, Pex2, Pmp35
Domain Architecture
Description	Peroxisome assembly factor 1 (PAF-1) (Peroxin-2) (Peroxisomal membrane protein 3).

RFPL2_HUMAN
θ value	8.99809 (rank : 419)	NC score	0.121002 (rank : 349)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	91
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

RFPL3_HUMAN
θ value	8.99809 (rank : 420)	NC score	0.124161 (rank : 343)
Query Neighborhood Hits	438	Target Neighborhood Hits	134	Shared Neighborhood Hits	93
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

RGS12_HUMAN
θ value	8.99809 (rank : 421)	NC score	0.185086 (rank : 255)
Query Neighborhood Hits	438	Target Neighborhood Hits	333	Shared Neighborhood Hits	106
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RIMS2_HUMAN
θ value	8.99809 (rank : 422)	NC score	0.140387 (rank : 314)
Query Neighborhood Hits	438	Target Neighborhood Hits	342	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

RIMS2_MOUSE
θ value	8.99809 (rank : 423)	NC score	0.138648 (rank : 317)
Query Neighborhood Hits	438	Target Neighborhood Hits	376	Shared Neighborhood Hits	102
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RN139_HUMAN
θ value	8.99809 (rank : 424)	NC score	0.084376 (rank : 418)
Query Neighborhood Hits	438	Target Neighborhood Hits	130	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WU17, O75485, Q7LDL3	Gene names	RNF139, TRC8
Domain Architecture	No domain graphic available
Description	RING finger protein 139 (Translocation in renal carcinoma on chromosome 8).

RN139_MOUSE
θ value	8.99809 (rank : 425)	NC score	0.088890 (rank : 412)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TMV1, Q8BZU9	Gene names	Rnf139
Domain Architecture	No domain graphic available
Description	RING finger protein 139.

RN165_HUMAN
θ value	8.99809 (rank : 426)	NC score	0.126972 (rank : 339)
Query Neighborhood Hits	438	Target Neighborhood Hits	151	Shared Neighborhood Hits	81
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

RNF13_HUMAN
θ value	8.99809 (rank : 427)	NC score	0.063733 (rank : 451)
Query Neighborhood Hits	438	Target Neighborhood Hits	147	Shared Neighborhood Hits	68
SwissProt Accessions	O43567	Gene names	RNF13, RZF
Domain Architecture
Description	RING finger protein 13.

RNF4_HUMAN
θ value	8.99809 (rank : 428)	NC score	0.224106 (rank : 203)
Query Neighborhood Hits	438	Target Neighborhood Hits	212	Shared Neighborhood Hits	153
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	8.99809 (rank : 429)	NC score	0.221826 (rank : 205)
Query Neighborhood Hits	438	Target Neighborhood Hits	212	Shared Neighborhood Hits	155
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

SETB1_HUMAN
θ value	8.99809 (rank : 430)	NC score	0.004150 (rank : 556)
Query Neighborhood Hits	438	Target Neighborhood Hits	141	Shared Neighborhood Hits	9
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

TIF1B_HUMAN
θ value	8.99809 (rank : 431)	NC score	0.056116 (rank : 473)
Query Neighborhood Hits	438	Target Neighborhood Hits	312	Shared Neighborhood Hits	99
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

TRI34_MOUSE
θ value	8.99809 (rank : 432)	NC score	0.178810 (rank : 266)
Query Neighborhood Hits	438	Target Neighborhood Hits	332	Shared Neighborhood Hits	138
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRIM2_HUMAN
θ value	8.99809 (rank : 433)	NC score	0.175096 (rank : 274)
Query Neighborhood Hits	438	Target Neighborhood Hits	330	Shared Neighborhood Hits	185
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM2_MOUSE
θ value	8.99809 (rank : 434)	NC score	0.173858 (rank : 275)
Query Neighborhood Hits	438	Target Neighborhood Hits	331	Shared Neighborhood Hits	184
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TXLNG_MOUSE
θ value	8.99809 (rank : 435)	NC score	0.032176 (rank : 502)
Query Neighborhood Hits	438	Target Neighborhood Hits	552	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

UB7I4_MOUSE
θ value	8.99809 (rank : 436)	NC score	0.006491 (rank : 550)
Query Neighborhood Hits	438	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

UHRF2_HUMAN
θ value	8.99809 (rank : 437)	NC score	0.132001 (rank : 327)
Query Neighborhood Hits	438	Target Neighborhood Hits	269	Shared Neighborhood Hits	142
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

UHRF2_MOUSE
θ value	8.99809 (rank : 438)	NC score	0.132483 (rank : 326)
Query Neighborhood Hits	438	Target Neighborhood Hits	275	Shared Neighborhood Hits	139
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

APXL_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.177334 (rank : 269)
Query Neighborhood Hits	438	Target Neighborhood Hits	553	Shared Neighborhood Hits	93
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

BIRC7_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.100962 (rank : 381)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	124
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BRAP_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.050978 (rank : 481)
Query Neighborhood Hits	438	Target Neighborhood Hits	560	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRAP_MOUSE
θ value	θ > 10 (rank : 442)	NC score	0.050648 (rank : 485)
Query Neighborhood Hits	438	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

BSPRY_HUMAN
θ value	θ > 10 (rank : 443)	NC score	0.111929 (rank : 366)
Query Neighborhood Hits	438	Target Neighborhood Hits	115	Shared Neighborhood Hits	68
SwissProt Accessions	Q5W0U4, Q96DJ2, Q9H4E4, Q9NXN0	Gene names	BSPRY
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

BSPRY_MOUSE
θ value	θ > 10 (rank : 444)	NC score	0.118304 (rank : 352)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

BT1A1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.096770 (rank : 386)
Query Neighborhood Hits	438	Target Neighborhood Hits	322	Shared Neighborhood Hits	57
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT1A1_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.098848 (rank : 383)
Query Neighborhood Hits	438	Target Neighborhood Hits	252	Shared Neighborhood Hits	59
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT2A1_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.092022 (rank : 403)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

BT2A2_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.095873 (rank : 390)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

BT2A3_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.090517 (rank : 409)
Query Neighborhood Hits	438	Target Neighborhood Hits	195	Shared Neighborhood Hits	53
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

BT3A1_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.096199 (rank : 389)
Query Neighborhood Hits	438	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

BT3A3_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.097746 (rank : 385)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	58
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BTNL3_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.096320 (rank : 388)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

BTNL8_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.092105 (rank : 402)
Query Neighborhood Hits	438	Target Neighborhood Hits	177	Shared Neighborhood Hits	55
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

BTNL9_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.094965 (rank : 394)
Query Neighborhood Hits	438	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UXG8, Q6P660, Q96DM5	Gene names	BTNL9
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 9 precursor.

CAR11_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.076057 (rank : 433)
Query Neighborhood Hits	438	Target Neighborhood Hits	690	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.062458 (rank : 455)
Query Neighborhood Hits	438	Target Neighborhood Hits	449	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CAR14_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.052559 (rank : 479)
Query Neighborhood Hits	438	Target Neighborhood Hits	526	Shared Neighborhood Hits	64
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

DTX3L_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.074958 (rank : 435)
Query Neighborhood Hits	438	Target Neighborhood Hits	187	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TDB6	Gene names	DTX3L, BBAP
Domain Architecture
Description	Protein deltex 3-like protein (B-lymphoma- and BAL-associated protein) (Rhysin-2) (Rhysin2).

DTX3_HUMAN
θ value	θ > 10 (rank : 459)	NC score	0.129135 (rank : 336)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	Q8N9I9, Q8NAU6, Q8NDS8	Gene names	DTX3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3).

DTX3_MOUSE
θ value	θ > 10 (rank : 460)	NC score	0.130072 (rank : 333)
Query Neighborhood Hits	438	Target Neighborhood Hits	202	Shared Neighborhood Hits	143
SwissProt Accessions	Q80V91, Q9ER06	Gene names	Dtx3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3) (mDTX3).

ERMAP_HUMAN
θ value	θ > 10 (rank : 461)	NC score	0.111354 (rank : 369)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

ERMAP_MOUSE
θ value	θ > 10 (rank : 462)	NC score	0.102490 (rank : 379)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

GIPC1_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.131387 (rank : 328)
Query Neighborhood Hits	438	Target Neighborhood Hits	91	Shared Neighborhood Hits	76
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

GIPC1_MOUSE
θ value	θ > 10 (rank : 464)	NC score	0.140374 (rank : 315)
Query Neighborhood Hits	438	Target Neighborhood Hits	92	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

GIPC2_HUMAN
θ value	θ > 10 (rank : 465)	NC score	0.114633 (rank : 359)
Query Neighborhood Hits	438	Target Neighborhood Hits	93	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

GIPC2_MOUSE
θ value	θ > 10 (rank : 466)	NC score	0.064017 (rank : 450)
Query Neighborhood Hits	438	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

GIPC3_HUMAN
θ value	θ > 10 (rank : 467)	NC score	0.062651 (rank : 454)
Query Neighborhood Hits	438	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

GIPC3_MOUSE
θ value	θ > 10 (rank : 468)	NC score	0.060941 (rank : 462)
Query Neighborhood Hits	438	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

KGUA_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.170130 (rank : 286)
Query Neighborhood Hits	438	Target Neighborhood Hits	41	Shared Neighborhood Hits	24
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

KGUA_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.170614 (rank : 284)
Query Neighborhood Hits	438	Target Neighborhood Hits	45	Shared Neighborhood Hits	24
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

LDB3_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.111650 (rank : 368)
Query Neighborhood Hits	438	Target Neighborhood Hits	497	Shared Neighborhood Hits	86
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LDB3_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.113655 (rank : 363)
Query Neighborhood Hits	438	Target Neighborhood Hits	510	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

LMO7_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.077092 (rank : 430)
Query Neighborhood Hits	438	Target Neighborhood Hits	507	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LRRC1_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.065473 (rank : 446)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

LRRC1_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.065763 (rank : 445)
Query Neighborhood Hits	438	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

LRSM1_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.062351 (rank : 456)
Query Neighborhood Hits	438	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRSM1_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.063184 (rank : 452)
Query Neighborhood Hits	438	Target Neighborhood Hits	874	Shared Neighborhood Hits	119
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MEFV_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.131187 (rank : 329)
Query Neighborhood Hits	438	Target Neighborhood Hits	431	Shared Neighborhood Hits	92
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.114327 (rank : 360)
Query Neighborhood Hits	438	Target Neighborhood Hits	236	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

MNAB_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.059252 (rank : 467)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

MNAB_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.058709 (rank : 468)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	95
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

MPP2_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.214661 (rank : 216)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	83
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

MPP2_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.216769 (rank : 215)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP6_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.217324 (rank : 212)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.220895 (rank : 207)
Query Neighborhood Hits	438	Target Neighborhood Hits	187	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MY18A_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.062188 (rank : 458)
Query Neighborhood Hits	438	Target Neighborhood Hits	1929	Shared Neighborhood Hits	214
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.065154 (rank : 447)
Query Neighborhood Hits	438	Target Neighborhood Hits	1989	Shared Neighborhood Hits	205
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NOS1_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.209313 (rank : 225)
Query Neighborhood Hits	438	Target Neighborhood Hits	218	Shared Neighborhood Hits	127
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NOS1_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.178311 (rank : 267)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PDLI1_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.141976 (rank : 312)
Query Neighborhood Hits	438	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.142476 (rank : 311)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	72
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI3_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.151293 (rank : 300)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	85
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI3_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.136555 (rank : 320)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	81
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI4_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.137825 (rank : 319)
Query Neighborhood Hits	438	Target Neighborhood Hits	245	Shared Neighborhood Hits	82
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI4_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.139728 (rank : 316)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	84
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI5_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.110685 (rank : 371)
Query Neighborhood Hits	438	Target Neighborhood Hits	322	Shared Neighborhood Hits	86
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI5_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.111696 (rank : 367)
Query Neighborhood Hits	438	Target Neighborhood Hits	287	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI7_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.101926 (rank : 380)
Query Neighborhood Hits	438	Target Neighborhood Hits	547	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDLI7_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.094974 (rank : 392)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	72
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD6_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.113861 (rank : 362)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

PDZD8_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.093101 (rank : 400)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PJA1_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.094322 (rank : 397)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

PJA1_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.090372 (rank : 410)
Query Neighborhood Hits	438	Target Neighborhood Hits	145	Shared Neighborhood Hits	76
SwissProt Accessions	O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04	Gene names	Pja1
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-).

PML_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.088181 (rank : 413)
Query Neighborhood Hits	438	Target Neighborhood Hits	248	Shared Neighborhood Hits	98
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

PML_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.090988 (rank : 407)
Query Neighborhood Hits	438	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

PRAX_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.062221 (rank : 457)
Query Neighborhood Hits	438	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

RBBP6_HUMAN
θ value	θ > 10 (rank : 507)	NC score	0.084476 (rank : 417)
Query Neighborhood Hits	438	Target Neighborhood Hits	1135	Shared Neighborhood Hits	161
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RBBP6_MOUSE
θ value	θ > 10 (rank : 508)	NC score	0.090739 (rank : 408)
Query Neighborhood Hits	438	Target Neighborhood Hits	1014	Shared Neighborhood Hits	155
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RFPL1_HUMAN
θ value	θ > 10 (rank : 509)	NC score	0.118231 (rank : 353)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

RHPN1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.191702 (rank : 246)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.204955 (rank : 230)
Query Neighborhood Hits	438	Target Neighborhood Hits	154	Shared Neighborhood Hits	101
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RING1_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.190339 (rank : 249)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	154
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.186785 (rank : 252)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	155
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

RING2_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.182996 (rank : 260)
Query Neighborhood Hits	438	Target Neighborhood Hits	201	Shared Neighborhood Hits	152
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.182972 (rank : 261)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	152
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

RKHD1_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.058156 (rank : 470)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RN133_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.063172 (rank : 453)
Query Neighborhood Hits	438	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WVZ7, Q8N7G7	Gene names	RNF133
Domain Architecture	No domain graphic available
Description	RING finger protein 133.

RN152_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.064455 (rank : 448)
Query Neighborhood Hits	438	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

RN152_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.067813 (rank : 442)
Query Neighborhood Hits	438	Target Neighborhood Hits	109	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

RN169_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.141524 (rank : 313)
Query Neighborhood Hits	438	Target Neighborhood Hits	203	Shared Neighborhood Hits	102
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RNF11_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.061700 (rank : 460)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y3C5	Gene names	RNF11
Domain Architecture
Description	RING finger protein 11 (Sid 1669).

RNF11_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.061438 (rank : 461)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QYK7, Q9EQI1	Gene names	Rnf11, N4wbp2, Sid1669
Domain Architecture
Description	RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669).

RNF12_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.050898 (rank : 483)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

RNF12_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.056495 (rank : 472)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

RNF32_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.072445 (rank : 437)
Query Neighborhood Hits	438	Target Neighborhood Hits	133	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H0A6, Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9Y6U1	Gene names	RNF32
Domain Architecture	No domain graphic available
Description	RING finger protein 32.

RNF32_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.066868 (rank : 444)
Query Neighborhood Hits	438	Target Neighborhood Hits	129	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JIT1, Q9D9X0, Q9DAJ3	Gene names	Rnf32, Lmbr2
Domain Architecture	No domain graphic available
Description	RING finger protein 32 (Limb region protein 2).

RNF38_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.058508 (rank : 469)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0F5, Q8N0Y0	Gene names	RNF38
Domain Architecture	No domain graphic available
Description	RING finger protein 38.

RNF38_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.057361 (rank : 471)
Query Neighborhood Hits	438	Target Neighborhood Hits	153	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BI21, Q6P5B1	Gene names	Rnf38
Domain Architecture	No domain graphic available
Description	RING finger protein 38.

RNF6_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.051995 (rank : 480)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

SHAN1_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.123446 (rank : 344)
Query Neighborhood Hits	438	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHAN2_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.181624 (rank : 264)
Query Neighborhood Hits	438	Target Neighborhood Hits	346	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.163831 (rank : 289)
Query Neighborhood Hits	438	Target Neighborhood Hits	446	Shared Neighborhood Hits	99
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPRY4_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.094764 (rank : 395)
Query Neighborhood Hits	438	Target Neighborhood Hits	79	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WW59	Gene names	SPRYD4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

SPRY4_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.096716 (rank : 387)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	55
SwissProt Accessions	Q91WK1, Q8BUS6, Q9D651	Gene names	Spryd4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

SYNP2_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.129936 (rank : 335)
Query Neighborhood Hits	438	Target Neighborhood Hits	323	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYNP2_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.173456 (rank : 276)
Query Neighborhood Hits	438	Target Neighborhood Hits	252	Shared Neighborhood Hits	96
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

SYP2L_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.202352 (rank : 232)
Query Neighborhood Hits	438	Target Neighborhood Hits	400	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYP2L_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.136134 (rank : 321)
Query Neighborhood Hits	438	Target Neighborhood Hits	289	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TIF1B_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.054112 (rank : 477)
Query Neighborhood Hits	438	Target Neighborhood Hits	276	Shared Neighborhood Hits	97
SwissProt Accessions	Q62318, P70391, Q8C283, Q99PN4	Gene names	Trim28, Krip1, Tif1b
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (KRAB-A-interacting protein) (KRIP-1).

TIF1G_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.060694 (rank : 464)
Query Neighborhood Hits	438	Target Neighborhood Hits	410	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TIF1G_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.060902 (rank : 463)
Query Neighborhood Hits	438	Target Neighborhood Hits	498	Shared Neighborhood Hits	112
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TRAF1_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.108543 (rank : 375)
Query Neighborhood Hits	438	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	Q13077, Q8NF13	Gene names	TRAF1, EBI6
Domain Architecture
Description	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6).

TRAF1_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.109057 (rank : 374)
Query Neighborhood Hits	438	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P39428	Gene names	Traf1
Domain Architecture
Description	TNF receptor-associated factor 1.

TRAIP_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.076151 (rank : 432)
Query Neighborhood Hits	438	Target Neighborhood Hits	780	Shared Neighborhood Hits	136
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAIP_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.070245 (rank : 440)
Query Neighborhood Hits	438	Target Neighborhood Hits	745	Shared Neighborhood Hits	127
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRI14_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.126865 (rank : 340)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	75
SwissProt Accessions	Q14142, Q9BRD8, Q9C020	Gene names	TRIM14, KIAA0129
Domain Architecture
Description	Tripartite motif-containing protein 14.

TRI14_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.126571 (rank : 341)
Query Neighborhood Hits	438	Target Neighborhood Hits	137	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

TRI16_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.119600 (rank : 351)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

TRI16_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.122326 (rank : 345)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PP9, Q7TPY6, Q8C332, Q8C6V0	Gene names	Trim16, Ebbp
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

TRI29_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.110604 (rank : 372)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q14134, Q96AA9, Q9BZY7	Gene names	TRIM29, ATDC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29 (Ataxia-telangiectasia group D- associated protein).

TRI29_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.113320 (rank : 364)
Query Neighborhood Hits	438	Target Neighborhood Hits	306	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R2Q0, Q8CEE2, Q922Y3, Q99PN5, Q9CSC9	Gene names	Trim29
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29.

TRI38_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.193594 (rank : 241)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	168
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRI41_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.183533 (rank : 258)
Query Neighborhood Hits	438	Target Neighborhood Hits	349	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI42_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.093440 (rank : 399)
Query Neighborhood Hits	438	Target Neighborhood Hits	283	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI42_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.092416 (rank : 401)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	102
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI44_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.110089 (rank : 373)
Query Neighborhood Hits	438	Target Neighborhood Hits	393	Shared Neighborhood Hits	87
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

TRI44_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.112753 (rank : 365)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

TRI45_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.074295 (rank : 436)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H8W5, Q5T2K4, Q5T2K5, Q8IYV6	Gene names	TRIM45, RNF99
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45 (RING finger protein 99).

TRI45_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.070298 (rank : 439)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	82
SwissProt Accessions	Q6PFY8, Q8BVT5	Gene names	Trim45
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45.

TRI54_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.151800 (rank : 299)
Query Neighborhood Hits	438	Target Neighborhood Hits	209	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.150545 (rank : 301)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	130
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI55_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.148928 (rank : 306)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRI63_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.149578 (rank : 303)
Query Neighborhood Hits	438	Target Neighborhood Hits	298	Shared Neighborhood Hits	133
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI63_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.153900 (rank : 296)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	130
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

TRIM3_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.170602 (rank : 285)
Query Neighborhood Hits	438	Target Neighborhood Hits	357	Shared Neighborhood Hits	174
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.173385 (rank : 277)
Query Neighborhood Hits	438	Target Neighborhood Hits	351	Shared Neighborhood Hits	176
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TTC3_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.064203 (rank : 449)
Query Neighborhood Hits	438	Target Neighborhood Hits	664	Shared Neighborhood Hits	96
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

WWC1_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.050949 (rank : 482)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

XE7_HUMAN
θ value	θ > 10 (rank : 569)	NC score	0.055420 (rank : 475)
Query Neighborhood Hits	438	Target Neighborhood Hits	738	Shared Neighborhood Hits	59
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

Hits sorted by NC score

PZRN4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	438	Target Neighborhood Hits	438	Shared Neighborhood Hits	438
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

PZRN3_MOUSE
NC score	0.962255 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	438	Target Neighborhood Hits	447	Shared Neighborhood Hits	333
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_HUMAN
NC score	0.960133 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	438	Target Neighborhood Hits	461	Shared Neighborhood Hits	328
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PDZK4_MOUSE
NC score	0.832430 (rank : 4)	θ value	4.6918e-174 (rank : 4)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_HUMAN
NC score	0.829980 (rank : 5)	θ value	1.04765e-165 (rank : 5)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	119
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

SYJ2B_HUMAN
NC score	0.699499 (rank : 6)	θ value	2.98157e-11 (rank : 22)
Query Neighborhood Hits	438	Target Neighborhood Hits	162	Shared Neighborhood Hits	137
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

LNX2_MOUSE
NC score	0.692061 (rank : 7)	θ value	1.06045e-08 (rank : 40)
Query Neighborhood Hits	438	Target Neighborhood Hits	407	Shared Neighborhood Hits	309
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

LNX1_MOUSE
NC score	0.684533 (rank : 8)	θ value	1.38499e-08 (rank : 42)
Query Neighborhood Hits	438	Target Neighborhood Hits	377	Shared Neighborhood Hits	299
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
NC score	0.679314 (rank : 9)	θ value	2.13673e-09 (rank : 30)
Query Neighborhood Hits	438	Target Neighborhood Hits	389	Shared Neighborhood Hits	306
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX1_HUMAN
NC score	0.677138 (rank : 10)	θ value	2.79066e-09 (rank : 33)
Query Neighborhood Hits	438	Target Neighborhood Hits	379	Shared Neighborhood Hits	298
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

INADL_HUMAN
NC score	0.650100 (rank : 11)	θ value	3.88503e-19 (rank : 7)
Query Neighborhood Hits	438	Target Neighborhood Hits	260	Shared Neighborhood Hits	153
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

INADL_MOUSE
NC score	0.649085 (rank : 12)	θ value	9.56915e-18 (rank : 9)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MPDZ_HUMAN
NC score	0.640211 (rank : 13)	θ value	9.56915e-18 (rank : 10)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	160
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
NC score	0.635760 (rank : 14)	θ value	1.52774e-15 (rank : 13)
Query Neighborhood Hits	438	Target Neighborhood Hits	298	Shared Neighborhood Hits	154
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

TX1B3_HUMAN
NC score	0.612639 (rank : 15)	θ value	1.47974e-10 (rank : 24)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	136
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.609839 (rank : 16)	θ value	1.47974e-10 (rank : 25)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	133
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

LIN7A_HUMAN
NC score	0.598303 (rank : 17)	θ value	2.79066e-09 (rank : 31)
Query Neighborhood Hits	438	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
NC score	0.598142 (rank : 18)	θ value	2.79066e-09 (rank : 32)
Query Neighborhood Hits	438	Target Neighborhood Hits	193	Shared Neighborhood Hits	150
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

PDZD7_HUMAN
NC score	0.596291 (rank : 19)	θ value	1.29631e-06 (rank : 68)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	143
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

LIN7B_HUMAN
NC score	0.595780 (rank : 20)	θ value	8.11959e-09 (rank : 36)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

LIN7B_MOUSE
NC score	0.595503 (rank : 21)	θ value	1.06045e-08 (rank : 37)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	154
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

LIN7C_HUMAN
NC score	0.592492 (rank : 22)	θ value	1.06045e-08 (rank : 38)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.592492 (rank : 23)	θ value	1.06045e-08 (rank : 39)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	154
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

PAR3L_HUMAN
NC score	0.589780 (rank : 24)	θ value	6.87365e-08 (rank : 47)
Query Neighborhood Hits	438	Target Neighborhood Hits	297	Shared Neighborhood Hits	141
SwissProt Accessions	Q8TEW8, Q8IUC7, Q8IUC9, Q96DK9, Q96N09, Q96NX6, Q96NX7, Q96Q29	Gene names	PARD3B, ALS2CR19, PAR3B, PAR3L
Domain Architecture
Description	Partitioning-defective 3 homolog B (PAR3-beta) (Partitioning-defective 3-like protein) (PAR3-L protein) (Amyotrophic lateral sclerosis 2 chromosome region candidate gene 19 protein).

USH1C_HUMAN
NC score	0.585149 (rank : 25)	θ value	2.61198e-07 (rank : 56)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

WHRN_MOUSE
NC score	0.579505 (rank : 26)	θ value	1.133e-10 (rank : 23)
Query Neighborhood Hits	438	Target Neighborhood Hits	412	Shared Neighborhood Hits	154
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

DLG4_MOUSE
NC score	0.578506 (rank : 27)	θ value	1.42992e-13 (rank : 18)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	147
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_HUMAN
NC score	0.578200 (rank : 28)	θ value	1.09485e-13 (rank : 17)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	147
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PARD3_HUMAN
NC score	0.577309 (rank : 29)	θ value	5.81887e-07 (rank : 62)
Query Neighborhood Hits	438	Target Neighborhood Hits	312	Shared Neighborhood Hits	155
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

WHRN_HUMAN
NC score	0.576748 (rank : 30)	θ value	2.88788e-06 (rank : 73)
Query Neighborhood Hits	438	Target Neighborhood Hits	325	Shared Neighborhood Hits	155
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

PARD3_MOUSE
NC score	0.572484 (rank : 31)	θ value	1.17247e-07 (rank : 51)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	152
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDZ11_HUMAN
NC score	0.570259 (rank : 32)	θ value	1.43324e-05 (rank : 85)
Query Neighborhood Hits	438	Target Neighborhood Hits	160	Shared Neighborhood Hits	123
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

DLG3_MOUSE
NC score	0.568154 (rank : 33)	θ value	6.41864e-14 (rank : 15)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	145
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DLG1_HUMAN
NC score	0.566812 (rank : 34)	θ value	7.09661e-13 (rank : 20)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	148
SwissProt Accessions	Q12959, Q12958	Gene names	DLG1
Domain Architecture
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (hDlg).

PDZ11_MOUSE
NC score	0.566719 (rank : 35)	θ value	4.1701e-05 (rank : 94)
Query Neighborhood Hits	438	Target Neighborhood Hits	154	Shared Neighborhood Hits	119
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

DLG3_HUMAN
NC score	0.566356 (rank : 36)	θ value	4.91457e-14 (rank : 14)
Query Neighborhood Hits	438	Target Neighborhood Hits	269	Shared Neighborhood Hits	145
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG1_MOUSE
NC score	0.565254 (rank : 37)	θ value	8.38298e-14 (rank : 16)
Query Neighborhood Hits	438	Target Neighborhood Hits	285	Shared Neighborhood Hits	147
SwissProt Accessions	Q811D0, Q62402, Q6PGB5, Q8CGN7	Gene names	Dlg1, Dlgh1
Domain Architecture	No domain graphic available
Description	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (Embryo-dlg/synapse-associated protein 97) (E-dlg/SAP97).

IL16_HUMAN
NC score	0.564269 (rank : 38)	θ value	5.81887e-07 (rank : 59)
Query Neighborhood Hits	438	Target Neighborhood Hits	207	Shared Neighborhood Hits	126
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

DLG2_HUMAN
NC score	0.560305 (rank : 39)	θ value	1.9326e-10 (rank : 26)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	147
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG2_MOUSE
NC score	0.557427 (rank : 40)	θ value	1.9326e-10 (rank : 27)
Query Neighborhood Hits	438	Target Neighborhood Hits	271	Shared Neighborhood Hits	147
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

IL16_MOUSE
NC score	0.551733 (rank : 41)	θ value	9.92553e-07 (rank : 65)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	123
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

PDZD2_HUMAN
NC score	0.549380 (rank : 42)	θ value	6.87365e-08 (rank : 48)
Query Neighborhood Hits	438	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

USH1C_MOUSE
NC score	0.540695 (rank : 43)	θ value	5.44631e-05 (rank : 98)
Query Neighborhood Hits	438	Target Neighborhood Hits	557	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GRIP2_HUMAN
NC score	0.534429 (rank : 44)	θ value	3.19293e-05 (rank : 91)
Query Neighborhood Hits	438	Target Neighborhood Hits	256	Shared Neighborhood Hits	152
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GOPC_MOUSE
NC score	0.533566 (rank : 45)	θ value	5.44631e-05 (rank : 97)
Query Neighborhood Hits	438	Target Neighborhood Hits	323	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BH60, Q8BSV4, Q920R1, Q9ET11	Gene names	Gopc
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST).

GOPC_HUMAN
NC score	0.526898 (rank : 46)	θ value	5.44631e-05 (rank : 96)
Query Neighborhood Hits	438	Target Neighborhood Hits	377	Shared Neighborhood Hits	159
SwissProt Accessions	Q9HD26, Q59FS4, Q969U8	Gene names	GOPC, CAL, FIG
Domain Architecture	No domain graphic available
Description	Golgi-associated PDZ and coiled-coil motif-containing protein (PDZ protein interacting specifically with TC10) (PIST) (CFTR-associated ligand) (Fused in glioblastoma).

GRIP1_HUMAN
NC score	0.518412 (rank : 47)	θ value	1.09739e-05 (rank : 82)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

MAGI1_MOUSE
NC score	0.517826 (rank : 48)	θ value	9.59137e-10 (rank : 28)
Query Neighborhood Hits	438	Target Neighborhood Hits	403	Shared Neighborhood Hits	159
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.517539 (rank : 49)	θ value	1.25267e-09 (rank : 29)
Query Neighborhood Hits	438	Target Neighborhood Hits	388	Shared Neighborhood Hits	158
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GRIP1_MOUSE
NC score	0.517095 (rank : 50)	θ value	1.09739e-05 (rank : 83)
Query Neighborhood Hits	438	Target Neighborhood Hits	241	Shared Neighborhood Hits	152
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

ZO3_MOUSE
NC score	0.513416 (rank : 51)	θ value	7.59969e-07 (rank : 64)
Query Neighborhood Hits	438	Target Neighborhood Hits	224	Shared Neighborhood Hits	155
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

MAGI2_MOUSE
NC score	0.511227 (rank : 52)	θ value	5.43371e-13 (rank : 19)
Query Neighborhood Hits	438	Target Neighborhood Hits	370	Shared Neighborhood Hits	156
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

ZO3_HUMAN
NC score	0.509606 (rank : 53)	θ value	3.77169e-06 (rank : 76)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	146
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

SNTB2_MOUSE
NC score	0.507868 (rank : 54)	θ value	1.53129e-07 (rank : 54)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	132
SwissProt Accessions	Q61235	Gene names	Sntb2, Snt2b2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

MAGI2_HUMAN
NC score	0.507850 (rank : 55)	θ value	2.28291e-11 (rank : 21)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	156
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SNTB2_HUMAN
NC score	0.506831 (rank : 56)	θ value	1.53129e-07 (rank : 53)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	132
SwissProt Accessions	Q13425, Q9BY09	Gene names	SNTB2, SNT2B2
Domain Architecture
Description	Beta-2-syntrophin (59 kDa dystrophin-associated protein A1 basic component 2) (Syntrophin 3) (SNT3) (Syntrophin-like) (SNTL).

SNTG2_HUMAN
NC score	0.502185 (rank : 57)	θ value	1.69304e-06 (rank : 69)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	144
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SNTA1_HUMAN
NC score	0.493911 (rank : 58)	θ value	1.17247e-07 (rank : 52)
Query Neighborhood Hits	438	Target Neighborhood Hits	186	Shared Neighborhood Hits	130
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SNTA1_MOUSE
NC score	0.493543 (rank : 59)	θ value	1.06045e-08 (rank : 41)
Query Neighborhood Hits	438	Target Neighborhood Hits	170	Shared Neighborhood Hits	126
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

ZO1_MOUSE
NC score	0.493246 (rank : 60)	θ value	1.38499e-08 (rank : 44)
Query Neighborhood Hits	438	Target Neighborhood Hits	453	Shared Neighborhood Hits	153
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

PDZD1_MOUSE
NC score	0.492961 (rank : 61)	θ value	1.29631e-06 (rank : 67)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	134
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

ZO1_HUMAN
NC score	0.490703 (rank : 62)	θ value	4.76016e-09 (rank : 35)
Query Neighborhood Hits	438	Target Neighborhood Hits	474	Shared Neighborhood Hits	155
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

SNTB1_MOUSE
NC score	0.483781 (rank : 63)	θ value	8.97725e-08 (rank : 50)
Query Neighborhood Hits	438	Target Neighborhood Hits	160	Shared Neighborhood Hits	121
SwissProt Accessions	Q99L88, O35925	Gene names	Sntb1, Snt2b1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Syntrophin 2).

SNTB1_HUMAN
NC score	0.483776 (rank : 64)	θ value	8.97725e-08 (rank : 49)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	122
SwissProt Accessions	Q13884, O14912, Q4KMG8	Gene names	SNTB1, SNT2B1
Domain Architecture
Description	Beta-1-syntrophin (59 kDa dystrophin-associated protein A1 basic component 1) (DAPA1B) (Tax interaction protein 43) (TIP-43) (Syntrophin 2) (BSYN2).

RNF41_MOUSE
NC score	0.481238 (rank : 65)	θ value	6.20254e-17 (rank : 12)
Query Neighborhood Hits	438	Target Neighborhood Hits	224	Shared Neighborhood Hits	157
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.480790 (rank : 66)	θ value	6.20254e-17 (rank : 11)
Query Neighborhood Hits	438	Target Neighborhood Hits	226	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

NHRF2_HUMAN
NC score	0.478610 (rank : 67)	θ value	0.000461057 (rank : 118)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	140
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHERF_MOUSE
NC score	0.477816 (rank : 68)	θ value	0.00134147 (rank : 132)
Query Neighborhood Hits	438	Target Neighborhood Hits	195	Shared Neighborhood Hits	132
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

SNTG2_MOUSE
NC score	0.475996 (rank : 69)	θ value	8.40245e-06 (rank : 81)
Query Neighborhood Hits	438	Target Neighborhood Hits	176	Shared Neighborhood Hits	133
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

PDZD1_HUMAN
NC score	0.472616 (rank : 70)	θ value	0.00298849 (rank : 140)
Query Neighborhood Hits	438	Target Neighborhood Hits	190	Shared Neighborhood Hits	133
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SNTG1_HUMAN
NC score	0.464681 (rank : 71)	θ value	0.00020696 (rank : 111)
Query Neighborhood Hits	438	Target Neighborhood Hits	181	Shared Neighborhood Hits	138
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

NHERF_HUMAN
NC score	0.464361 (rank : 72)	θ value	0.00134147 (rank : 131)
Query Neighborhood Hits	438	Target Neighborhood Hits	190	Shared Neighborhood Hits	130
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

SNTG1_MOUSE
NC score	0.462847 (rank : 73)	θ value	0.000270298 (rank : 114)
Query Neighborhood Hits	438	Target Neighborhood Hits	179	Shared Neighborhood Hits	137
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

NHRF2_MOUSE
NC score	0.458752 (rank : 74)	θ value	0.00665767 (rank : 145)
Query Neighborhood Hits	438	Target Neighborhood Hits	194	Shared Neighborhood Hits	140
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

ZO2_HUMAN
NC score	0.453724 (rank : 75)	θ value	0.000270298 (rank : 115)
Query Neighborhood Hits	438	Target Neighborhood Hits	289	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZO2_MOUSE
NC score	0.452322 (rank : 76)	θ value	0.000602161 (rank : 122)
Query Neighborhood Hits	438	Target Neighborhood Hits	296	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

LAP4_HUMAN
NC score	0.423630 (rank : 77)	θ value	5.07402e-19 (rank : 8)
Query Neighborhood Hits	438	Target Neighborhood Hits	608	Shared Neighborhood Hits	165
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

LAP4_MOUSE
NC score	0.421143 (rank : 78)	θ value	5.99374e-20 (rank : 6)
Query Neighborhood Hits	438	Target Neighborhood Hits	590	Shared Neighborhood Hits	161
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

K1849_HUMAN
NC score	0.419139 (rank : 79)	θ value	0.00134147 (rank : 130)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	130
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

PDZD3_HUMAN
NC score	0.415273 (rank : 80)	θ value	0.279714 (rank : 257)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	131
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

K1849_MOUSE
NC score	0.411418 (rank : 81)	θ value	0.00175202 (rank : 134)
Query Neighborhood Hits	438	Target Neighborhood Hits	335	Shared Neighborhood Hits	139
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

DVL1_HUMAN
NC score	0.411301 (rank : 82)	θ value	5.44631e-05 (rank : 95)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	114
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_HUMAN
NC score	0.407231 (rank : 83)	θ value	0.000270298 (rank : 112)
Query Neighborhood Hits	438	Target Neighborhood Hits	194	Shared Neighborhood Hits	112
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1_MOUSE
NC score	0.407084 (rank : 84)	θ value	7.1131e-05 (rank : 100)
Query Neighborhood Hits	438	Target Neighborhood Hits	146	Shared Neighborhood Hits	111
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

DVL3_MOUSE
NC score	0.406996 (rank : 85)	θ value	0.000270298 (rank : 113)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	111
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL1L_HUMAN
NC score	0.398028 (rank : 86)	θ value	0.000121331 (rank : 103)
Query Neighborhood Hits	438	Target Neighborhood Hits	146	Shared Neighborhood Hits	112
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

PDZD3_MOUSE
NC score	0.397384 (rank : 87)	θ value	0.0431538 (rank : 174)
Query Neighborhood Hits	438	Target Neighborhood Hits	171	Shared Neighborhood Hits	128
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

DVL2_HUMAN
NC score	0.389462 (rank : 88)	θ value	0.000121331 (rank : 104)
Query Neighborhood Hits	438	Target Neighborhood Hits	223	Shared Neighborhood Hits	107
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.389264 (rank : 89)	θ value	0.000121331 (rank : 105)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	109
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

NEB1_HUMAN
NC score	0.380260 (rank : 90)	θ value	2.21117e-06 (rank : 71)
Query Neighborhood Hits	438	Target Neighborhood Hits	829	Shared Neighborhood Hits	159
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

DLG5_HUMAN
NC score	0.378808 (rank : 91)	θ value	6.43352e-06 (rank : 78)
Query Neighborhood Hits	438	Target Neighborhood Hits	1088	Shared Neighborhood Hits	197
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

ZN313_MOUSE
NC score	0.374697 (rank : 92)	θ value	2.61198e-07 (rank : 57)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	185
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

RN125_MOUSE
NC score	0.370044 (rank : 93)	θ value	7.59969e-07 (rank : 63)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	156
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

TRAF6_MOUSE
NC score	0.368507 (rank : 94)	θ value	3.08544e-08 (rank : 46)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	160
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

RN125_HUMAN
NC score	0.367685 (rank : 95)	θ value	3.77169e-06 (rank : 75)
Query Neighborhood Hits	438	Target Neighborhood Hits	230	Shared Neighborhood Hits	164
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

ZN313_HUMAN
NC score	0.367065 (rank : 96)	θ value	2.88788e-06 (rank : 74)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	181
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

AFAD_HUMAN
NC score	0.362158 (rank : 97)	θ value	0.47712 (rank : 271)
Query Neighborhood Hits	438	Target Neighborhood Hits	689	Shared Neighborhood Hits	160
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

TRAF6_HUMAN
NC score	0.361680 (rank : 98)	θ value	4.76016e-09 (rank : 34)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

NEB2_HUMAN
NC score	0.357585 (rank : 99)	θ value	1.87187e-05 (rank : 87)
Query Neighborhood Hits	438	Target Neighborhood Hits	883	Shared Neighborhood Hits	164
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
NC score	0.353990 (rank : 100)	θ value	1.87187e-05 (rank : 88)
Query Neighborhood Hits	438	Target Neighborhood Hits	889	Shared Neighborhood Hits	165
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

RN166_MOUSE
NC score	0.350881 (rank : 101)	θ value	6.43352e-06 (rank : 79)
Query Neighborhood Hits	438	Target Neighborhood Hits	248	Shared Neighborhood Hits	166
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

PEX10_HUMAN
NC score	0.348489 (rank : 102)	θ value	3.19293e-05 (rank : 92)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	176
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

PTN13_HUMAN
NC score	0.347937 (rank : 103)	θ value	1.80886e-08 (rank : 45)
Query Neighborhood Hits	438	Target Neighborhood Hits	471	Shared Neighborhood Hits	152
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

RN166_HUMAN
NC score	0.344712 (rank : 104)	θ value	2.44474e-05 (rank : 89)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	162
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

PTN13_MOUSE
NC score	0.339943 (rank : 105)	θ value	1.38499e-08 (rank : 43)
Query Neighborhood Hits	438	Target Neighborhood Hits	426	Shared Neighborhood Hits	152
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

MPP4_HUMAN
NC score	0.339170 (rank : 106)	θ value	0.00228821 (rank : 136)
Query Neighborhood Hits	438	Target Neighborhood Hits	205	Shared Neighborhood Hits	127
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

STXB4_HUMAN
NC score	0.332965 (rank : 107)	θ value	0.00102713 (rank : 125)
Query Neighborhood Hits	438	Target Neighborhood Hits	616	Shared Neighborhood Hits	131
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
NC score	0.328195 (rank : 108)	θ value	0.00869519 (rank : 150)
Query Neighborhood Hits	438	Target Neighborhood Hits	629	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

PAR6B_MOUSE
NC score	0.323961 (rank : 109)	θ value	0.62314 (rank : 287)
Query Neighborhood Hits	438	Target Neighborhood Hits	128	Shared Neighborhood Hits	111
SwissProt Accessions	Q9JK83, Q8R3J8	Gene names	Pard6b, Par6b
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

MPP5_HUMAN
NC score	0.323883 (rank : 110)	θ value	0.125558 (rank : 226)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	124
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
NC score	0.323059 (rank : 111)	θ value	0.125558 (rank : 227)
Query Neighborhood Hits	438	Target Neighborhood Hits	226	Shared Neighborhood Hits	124
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP3_MOUSE
NC score	0.322957 (rank : 112)	θ value	0.0148317 (rank : 155)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	116
SwissProt Accessions	O88910	Gene names	Mpp3, Dlgh3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Dlgh3 protein).

PAR6G_HUMAN
NC score	0.321292 (rank : 113)	θ value	0.0961366 (rank : 211)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BYG4	Gene names	PARD6G, PAR6G
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D).

PAR6B_HUMAN
NC score	0.320915 (rank : 114)	θ value	0.365318 (rank : 265)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BYG5, Q9Y510	Gene names	PARD6B, PAR6B
Domain Architecture
Description	Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B).

PAR6G_MOUSE
NC score	0.318430 (rank : 115)	θ value	0.279714 (rank : 255)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JK84	Gene names	Pard6g, Par6g
Domain Architecture
Description	Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6A).

MPP3_HUMAN
NC score	0.314386 (rank : 116)	θ value	0.0330416 (rank : 168)
Query Neighborhood Hits	438	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q13368	Gene names	MPP3, DLG3
Domain Architecture
Description	MAGUK p55 subfamily member 3 (Protein MPP3) (Discs large homolog 3).

TRAF5_MOUSE
NC score	0.313029 (rank : 117)	θ value	1.53129e-07 (rank : 55)
Query Neighborhood Hits	438	Target Neighborhood Hits	355	Shared Neighborhood Hits	137
SwissProt Accessions	P70191, Q61480	Gene names	Traf5
Domain Architecture
Description	TNF receptor-associated factor 5.

SDCB1_MOUSE
NC score	0.309179 (rank : 118)	θ value	0.21417 (rank : 247)
Query Neighborhood Hits	438	Target Neighborhood Hits	144	Shared Neighborhood Hits	120
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

PSCBP_MOUSE
NC score	0.308782 (rank : 119)	θ value	0.00298849 (rank : 141)
Query Neighborhood Hits	438	Target Neighborhood Hits	118	Shared Neighborhood Hits	90
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SDCB1_HUMAN
NC score	0.308084 (rank : 120)	θ value	0.21417 (rank : 246)
Query Neighborhood Hits	438	Target Neighborhood Hits	150	Shared Neighborhood Hits	127
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

PICK1_MOUSE
NC score	0.305184 (rank : 121)	θ value	1.81305 (rank : 318)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	113
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

TRAF5_HUMAN
NC score	0.304020 (rank : 122)	θ value	1.69304e-06 (rank : 70)
Query Neighborhood Hits	438	Target Neighborhood Hits	396	Shared Neighborhood Hits	136
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

MPP4_MOUSE
NC score	0.301603 (rank : 123)	θ value	0.00228821 (rank : 137)
Query Neighborhood Hits	438	Target Neighborhood Hits	188	Shared Neighborhood Hits	107
SwissProt Accessions	Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8	Gene names	Mpp4, Dlg6
Domain Architecture	No domain graphic available
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (MDLG6).

PAR6A_MOUSE
NC score	0.301062 (rank : 124)	θ value	0.125558 (rank : 229)
Query Neighborhood Hits	438	Target Neighborhood Hits	115	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Z101, Q5RL03, Q6P8R2	Gene names	Pard6a, Par6a
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6).

PICK1_HUMAN
NC score	0.300857 (rank : 125)	θ value	4.03905 (rank : 357)
Query Neighborhood Hits	438	Target Neighborhood Hits	132	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PAR6A_HUMAN
NC score	0.300131 (rank : 126)	θ value	0.125558 (rank : 228)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NPB6, O14911, Q9NPJ7	Gene names	PARD6A, PAR6A
Domain Architecture
Description	Partitioning defective 6 homolog alpha (PAR-6 alpha) (PAR-6A) (PAR-6) (PAR6C) (Tax interaction protein 40) (TIP-40).

RPGF6_HUMAN
NC score	0.298770 (rank : 127)	θ value	0.0193708 (rank : 159)
Query Neighborhood Hits	438	Target Neighborhood Hits	266	Shared Neighborhood Hits	130
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TRAF4_HUMAN
NC score	0.298293 (rank : 128)	θ value	3.41135e-07 (rank : 58)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	139
SwissProt Accessions	Q9BUZ4, O75615, Q14848, Q2PJN8	Gene names	TRAF4, CART1, MLN62, RNF83
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Malignant 62) (RING finger protein 83).

TRI65_HUMAN
NC score	0.296181 (rank : 129)	θ value	7.1131e-05 (rank : 101)
Query Neighborhood Hits	438	Target Neighborhood Hits	330	Shared Neighborhood Hits	194
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

APBA1_HUMAN
NC score	0.295750 (rank : 130)	θ value	0.125558 (rank : 220)
Query Neighborhood Hits	438	Target Neighborhood Hits	325	Shared Neighborhood Hits	133
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

RAG1_HUMAN
NC score	0.293992 (rank : 131)	θ value	3.19293e-05 (rank : 93)
Query Neighborhood Hits	438	Target Neighborhood Hits	203	Shared Neighborhood Hits	141
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

APBA2_MOUSE
NC score	0.293420 (rank : 132)	θ value	0.0330416 (rank : 166)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_HUMAN
NC score	0.291832 (rank : 133)	θ value	0.0330416 (rank : 165)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	129
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

RAG1_MOUSE
NC score	0.287642 (rank : 134)	θ value	0.000158464 (rank : 107)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	143
SwissProt Accessions	P15919	Gene names	Rag1, Rag-1
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1).

EM55_MOUSE
NC score	0.286744 (rank : 135)	θ value	0.0961366 (rank : 210)
Query Neighborhood Hits	438	Target Neighborhood Hits	221	Shared Neighborhood Hits	109
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EM55_HUMAN
NC score	0.285916 (rank : 136)	θ value	0.125558 (rank : 223)
Query Neighborhood Hits	438	Target Neighborhood Hits	228	Shared Neighborhood Hits	111
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

BRCA1_HUMAN
NC score	0.285490 (rank : 137)	θ value	0.000121331 (rank : 102)
Query Neighborhood Hits	438	Target Neighborhood Hits	381	Shared Neighborhood Hits	183
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

PSCBP_HUMAN
NC score	0.284917 (rank : 138)	θ value	0.00102713 (rank : 124)
Query Neighborhood Hits	438	Target Neighborhood Hits	123	Shared Neighborhood Hits	95
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

TRI25_MOUSE
NC score	0.278467 (rank : 139)	θ value	1.43324e-05 (rank : 86)
Query Neighborhood Hits	438	Target Neighborhood Hits	446	Shared Neighborhood Hits	199
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRAF3_MOUSE
NC score	0.276480 (rank : 140)	θ value	4.92598e-06 (rank : 77)
Query Neighborhood Hits	438	Target Neighborhood Hits	476	Shared Neighborhood Hits	147
SwissProt Accessions	Q60803, Q62380	Gene names	Traf3, Craf1, Trafamn
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN).

TRI65_MOUSE
NC score	0.276378 (rank : 141)	θ value	0.00102713 (rank : 126)
Query Neighborhood Hits	438	Target Neighborhood Hits	340	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRAF3_HUMAN
NC score	0.276221 (rank : 142)	θ value	6.43352e-06 (rank : 80)
Query Neighborhood Hits	438	Target Neighborhood Hits	463	Shared Neighborhood Hits	141
SwissProt Accessions	Q13114, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1	Gene names	TRAF3, CAP1, CRAF1
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein) (LAP1) (CAP-1).

GRASP_HUMAN
NC score	0.274616 (rank : 143)	θ value	1.38821 (rank : 309)
Query Neighborhood Hits	438	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

BRCA1_MOUSE
NC score	0.272698 (rank : 144)	θ value	7.1131e-05 (rank : 99)
Query Neighborhood Hits	438	Target Neighborhood Hits	436	Shared Neighborhood Hits	178
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

APBA3_HUMAN
NC score	0.271285 (rank : 145)	θ value	6.88961 (rank : 388)
Query Neighborhood Hits	438	Target Neighborhood Hits	201	Shared Neighborhood Hits	114
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

GRASP_MOUSE
NC score	0.271116 (rank : 146)	θ value	3.0926 (rank : 338)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SDCB2_MOUSE
NC score	0.270884 (rank : 147)	θ value	0.365318 (rank : 266)
Query Neighborhood Hits	438	Target Neighborhood Hits	118	Shared Neighborhood Hits	99
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

PDLI2_HUMAN
NC score	0.269886 (rank : 148)	θ value	0.163984 (rank : 237)
Query Neighborhood Hits	438	Target Neighborhood Hits	245	Shared Neighborhood Hits	102
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

TRAF4_MOUSE
NC score	0.269754 (rank : 149)	θ value	1.09739e-05 (rank : 84)
Query Neighborhood Hits	438	Target Neighborhood Hits	338	Shared Neighborhood Hits	106
SwissProt Accessions	Q61382	Gene names	Traf4, Cart1
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1).

APBA3_MOUSE
NC score	0.266308 (rank : 150)	θ value	1.38821 (rank : 307)
Query Neighborhood Hits	438	Target Neighborhood Hits	174	Shared Neighborhood Hits	111
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

TRI25_HUMAN
NC score	0.266246 (rank : 151)	θ value	0.000461057 (rank : 119)
Query Neighborhood Hits	438	Target Neighborhood Hits	472	Shared Neighborhood Hits	195
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI40_HUMAN
NC score	0.265248 (rank : 152)	θ value	0.279714 (rank : 262)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	169
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

RN185_HUMAN
NC score	0.260425 (rank : 153)	θ value	0.0736092 (rank : 199)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	157
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF8_MOUSE
NC score	0.259970 (rank : 154)	θ value	0.00869519 (rank : 149)
Query Neighborhood Hits	438	Target Neighborhood Hits	618	Shared Neighborhood Hits	214
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

RPGF2_HUMAN
NC score	0.259796 (rank : 155)	θ value	0.0961366 (rank : 213)
Query Neighborhood Hits	438	Target Neighborhood Hits	242	Shared Neighborhood Hits	124
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RN185_MOUSE
NC score	0.259447 (rank : 156)	θ value	0.0736092 (rank : 200)
Query Neighborhood Hits	438	Target Neighborhood Hits	211	Shared Neighborhood Hits	155
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRI26_HUMAN
NC score	0.258147 (rank : 157)	θ value	0.00035302 (rank : 116)
Query Neighborhood Hits	438	Target Neighborhood Hits	335	Shared Neighborhood Hits	194
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI26_MOUSE
NC score	0.257102 (rank : 158)	θ value	0.000461057 (rank : 120)
Query Neighborhood Hits	438	Target Neighborhood Hits	339	Shared Neighborhood Hits	195
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI73_HUMAN
NC score	0.256209 (rank : 159)	θ value	0.00102713 (rank : 127)
Query Neighborhood Hits	438	Target Neighborhood Hits	258	Shared Neighborhood Hits	170
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI31_HUMAN
NC score	0.255225 (rank : 160)	θ value	0.163984 (rank : 241)
Query Neighborhood Hits	438	Target Neighborhood Hits	299	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

BFAR_HUMAN
NC score	0.254409 (rank : 161)	θ value	0.0252991 (rank : 161)
Query Neighborhood Hits	438	Target Neighborhood Hits	222	Shared Neighborhood Hits	156
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

TRI47_HUMAN
NC score	0.252557 (rank : 162)	θ value	0.00869519 (rank : 151)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	167
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
NC score	0.251251 (rank : 163)	θ value	0.00869519 (rank : 152)
Query Neighborhood Hits	438	Target Neighborhood Hits	295	Shared Neighborhood Hits	166
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

RNF8_HUMAN
NC score	0.250558 (rank : 164)	θ value	0.00665767 (rank : 146)
Query Neighborhood Hits	438	Target Neighborhood Hits	622	Shared Neighborhood Hits	211
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

BFAR_MOUSE
NC score	0.250495 (rank : 165)	θ value	0.0736092 (rank : 193)
Query Neighborhood Hits	438	Target Neighborhood Hits	232	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRI74_HUMAN
NC score	0.248792 (rank : 166)	θ value	0.00134147 (rank : 133)
Query Neighborhood Hits	438	Target Neighborhood Hits	249	Shared Neighborhood Hits	164
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

RNF5_HUMAN
NC score	0.247922 (rank : 167)	θ value	0.0736092 (rank : 201)
Query Neighborhood Hits	438	Target Neighborhood Hits	206	Shared Neighborhood Hits	155
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

TRI13_MOUSE
NC score	0.247553 (rank : 168)	θ value	0.21417 (rank : 250)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	186
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI59_MOUSE
NC score	0.247243 (rank : 169)	θ value	0.0563607 (rank : 191)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	174
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI13_HUMAN
NC score	0.246634 (rank : 170)	θ value	0.0961366 (rank : 215)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	184
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI59_HUMAN
NC score	0.246180 (rank : 171)	θ value	0.0563607 (rank : 190)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	177
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI52_HUMAN
NC score	0.246176 (rank : 172)	θ value	6.88961 (rank : 408)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	154
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

SDCB2_HUMAN
NC score	0.246005 (rank : 173)	θ value	4.03905 (rank : 359)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	99
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

RN168_HUMAN
NC score	0.244994 (rank : 174)	θ value	0.47712 (rank : 277)
Query Neighborhood Hits	438	Target Neighborhood Hits	370	Shared Neighborhood Hits	158
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN168_MOUSE
NC score	0.244782 (rank : 175)	θ value	0.62314 (rank : 288)
Query Neighborhood Hits	438	Target Neighborhood Hits	440	Shared Neighborhood Hits	173
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

ARHGB_HUMAN
NC score	0.244753 (rank : 176)	θ value	0.0736092 (rank : 192)
Query Neighborhood Hits	438	Target Neighborhood Hits	375	Shared Neighborhood Hits	135
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LRRC7_HUMAN
NC score	0.243508 (rank : 177)	θ value	5.81887e-07 (rank : 60)
Query Neighborhood Hits	438	Target Neighborhood Hits	423	Shared Neighborhood Hits	111
SwissProt Accessions	Q96NW7, Q5VXC2, Q5VXC3, Q68D07, Q86VE8, Q8WX20, Q9P2I2	Gene names	LRRC7, KIAA1365, LAP1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

RNF5_MOUSE
NC score	0.243449 (rank : 178)	θ value	0.0961366 (rank : 212)
Query Neighborhood Hits	438	Target Neighborhood Hits	206	Shared Neighborhood Hits	152
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

CHFR_MOUSE
NC score	0.242867 (rank : 179)	θ value	0.0961366 (rank : 209)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	162
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI12_MOUSE
NC score	0.242507 (rank : 180)	θ value	1.06291 (rank : 306)
Query Neighborhood Hits	438	Target Neighborhood Hits	387	Shared Neighborhood Hits	175
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

LRRC7_MOUSE
NC score	0.242479 (rank : 181)	θ value	5.81887e-07 (rank : 61)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TE7	Gene names	Lrrc7, Kiaa1365, Lap1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

TRIM8_MOUSE
NC score	0.242273 (rank : 182)	θ value	0.21417 (rank : 252)
Query Neighborhood Hits	438	Target Neighborhood Hits	674	Shared Neighborhood Hits	181
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_HUMAN
NC score	0.242143 (rank : 183)	θ value	0.21417 (rank : 251)
Query Neighborhood Hits	438	Target Neighborhood Hits	650	Shared Neighborhood Hits	184
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

PDLI2_MOUSE
NC score	0.241249 (rank : 184)	θ value	0.0431538 (rank : 173)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	93
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

TRI50_HUMAN
NC score	0.240412 (rank : 185)	θ value	0.000158464 (rank : 108)
Query Neighborhood Hits	438	Target Neighborhood Hits	294	Shared Neighborhood Hits	179
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

ZN179_HUMAN
NC score	0.238558 (rank : 186)	θ value	0.0736092 (rank : 204)
Query Neighborhood Hits	438	Target Neighborhood Hits	178	Shared Neighborhood Hits	134
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

TRI35_HUMAN
NC score	0.238161 (rank : 187)	θ value	0.813845 (rank : 294)
Query Neighborhood Hits	438	Target Neighborhood Hits	382	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

CHFR_HUMAN
NC score	0.236697 (rank : 188)	θ value	0.0961366 (rank : 208)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	159
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

LAP2_HUMAN
NC score	0.234761 (rank : 189)	θ value	0.00020696 (rank : 109)
Query Neighborhood Hits	438	Target Neighborhood Hits	499	Shared Neighborhood Hits	113
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

TRI35_MOUSE
NC score	0.234533 (rank : 190)	θ value	0.279714 (rank : 259)
Query Neighborhood Hits	438	Target Neighborhood Hits	465	Shared Neighborhood Hits	187
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRIM4_HUMAN
NC score	0.233763 (rank : 191)	θ value	0.0431538 (rank : 185)
Query Neighborhood Hits	438	Target Neighborhood Hits	321	Shared Neighborhood Hits	181
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRI50_MOUSE
NC score	0.232909 (rank : 192)	θ value	0.0330416 (rank : 170)
Query Neighborhood Hits	438	Target Neighborhood Hits	326	Shared Neighborhood Hits	190
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI30_MOUSE
NC score	0.231908 (rank : 193)	θ value	0.0193708 (rank : 160)
Query Neighborhood Hits	438	Target Neighborhood Hits	434	Shared Neighborhood Hits	189
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI22_HUMAN
NC score	0.231742 (rank : 194)	θ value	0.0431538 (rank : 178)
Query Neighborhood Hits	438	Target Neighborhood Hits	396	Shared Neighborhood Hits	175
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

ARHGC_HUMAN
NC score	0.231037 (rank : 195)	θ value	0.0961366 (rank : 207)
Query Neighborhood Hits	438	Target Neighborhood Hits	351	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.229504 (rank : 196)	θ value	0.0431538 (rank : 171)
Query Neighborhood Hits	438	Target Neighborhood Hits	344	Shared Neighborhood Hits	126
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TRI10_HUMAN
NC score	0.229006 (rank : 197)	θ value	0.00665767 (rank : 147)
Query Neighborhood Hits	438	Target Neighborhood Hits	315	Shared Neighborhood Hits	177
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI43_HUMAN
NC score	0.227706 (rank : 198)	θ value	0.0431538 (rank : 181)
Query Neighborhood Hits	438	Target Neighborhood Hits	341	Shared Neighborhood Hits	174
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

R113A_HUMAN
NC score	0.226854 (rank : 199)	θ value	0.0431538 (rank : 175)
Query Neighborhood Hits	438	Target Neighborhood Hits	177	Shared Neighborhood Hits	126
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

LAP2_MOUSE
NC score	0.225557 (rank : 200)	θ value	0.00020696 (rank : 110)
Query Neighborhood Hits	438	Target Neighborhood Hits	482	Shared Neighborhood Hits	109
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

TRI10_MOUSE
NC score	0.225257 (rank : 201)	θ value	0.00390308 (rank : 142)
Query Neighborhood Hits	438	Target Neighborhood Hits	285	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRIM6_HUMAN
NC score	0.224679 (rank : 202)	θ value	0.000786445 (rank : 123)
Query Neighborhood Hits	438	Target Neighborhood Hits	412	Shared Neighborhood Hits	180
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

RNF4_HUMAN
NC score	0.224106 (rank : 203)	θ value	8.99809 (rank : 428)
Query Neighborhood Hits	438	Target Neighborhood Hits	212	Shared Neighborhood Hits	153
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

TRIM5_HUMAN
NC score	0.223570 (rank : 204)	θ value	0.125558 (rank : 234)
Query Neighborhood Hits	438	Target Neighborhood Hits	424	Shared Neighborhood Hits	187
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

RNF4_MOUSE
NC score	0.221826 (rank : 205)	θ value	8.99809 (rank : 429)
Query Neighborhood Hits	438	Target Neighborhood Hits	212	Shared Neighborhood Hits	155
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

TRI68_MOUSE
NC score	0.221285 (rank : 206)	θ value	0.000121331 (rank : 106)
Query Neighborhood Hits	438	Target Neighborhood Hits	356	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

MPP6_MOUSE
NC score	0.220895 (rank : 207)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	438	Target Neighborhood Hits	187	Shared Neighborhood Hits	87
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

TRI60_HUMAN
NC score	0.219692 (rank : 208)	θ value	0.279714 (rank : 263)
Query Neighborhood Hits	438	Target Neighborhood Hits	357	Shared Neighborhood Hits	184
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

TRIM6_MOUSE
NC score	0.218661 (rank : 209)	θ value	0.00869519 (rank : 153)
Query Neighborhood Hits	438	Target Neighborhood Hits	451	Shared Neighborhood Hits	184
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRI39_HUMAN
NC score	0.217384 (rank : 210)	θ value	0.0431538 (rank : 179)
Query Neighborhood Hits	438	Target Neighborhood Hits	693	Shared Neighborhood Hits	216
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI60_MOUSE
NC score	0.217379 (rank : 211)	θ value	0.00509761 (rank : 143)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	156
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

MPP6_HUMAN
NC score	0.217324 (rank : 212)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	438	Target Neighborhood Hits	180	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

TRI39_MOUSE
NC score	0.216996 (rank : 213)	θ value	0.0431538 (rank : 180)
Query Neighborhood Hits	438	Target Neighborhood Hits	691	Shared Neighborhood Hits	214
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI68_HUMAN
NC score	0.216991 (rank : 214)	θ value	0.00035302 (rank : 117)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	166
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

MPP2_MOUSE
NC score	0.216769 (rank : 215)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	438	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q9WV34	Gene names	Mpp2, Dlgh2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Dlgh2 protein).

MPP2_HUMAN
NC score	0.214661 (rank : 216)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	83
SwissProt Accessions	Q14168, Q9BQJ2	Gene names	MPP2, DLG2
Domain Architecture
Description	MAGUK p55 subfamily member 2 (Protein MPP2) (Discs large homolog 2).

TRIM7_MOUSE
NC score	0.213582 (rank : 217)	θ value	0.00228821 (rank : 139)
Query Neighborhood Hits	438	Target Neighborhood Hits	358	Shared Neighborhood Hits	173
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

R113B_HUMAN
NC score	0.212543 (rank : 218)	θ value	0.0148317 (rank : 156)
Query Neighborhood Hits	438	Target Neighborhood Hits	165	Shared Neighborhood Hits	126
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

TRI11_HUMAN
NC score	0.211653 (rank : 219)	θ value	0.365318 (rank : 267)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	174
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI62_MOUSE
NC score	0.211599 (rank : 220)	θ value	0.47712 (rank : 279)
Query Neighborhood Hits	438	Target Neighborhood Hits	478	Shared Neighborhood Hits	187
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI11_MOUSE
NC score	0.210581 (rank : 221)	θ value	1.38821 (rank : 312)
Query Neighborhood Hits	438	Target Neighborhood Hits	329	Shared Neighborhood Hits	171
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI17_HUMAN
NC score	0.210358 (rank : 222)	θ value	0.0961366 (rank : 216)
Query Neighborhood Hits	438	Target Neighborhood Hits	318	Shared Neighborhood Hits	172
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

RO52_MOUSE
NC score	0.209524 (rank : 223)	θ value	1.06291 (rank : 303)
Query Neighborhood Hits	438	Target Neighborhood Hits	360	Shared Neighborhood Hits	181
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

RO52_HUMAN
NC score	0.209390 (rank : 224)	θ value	5.27518 (rank : 378)
Query Neighborhood Hits	438	Target Neighborhood Hits	419	Shared Neighborhood Hits	201
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

NOS1_HUMAN
NC score	0.209313 (rank : 225)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	438	Target Neighborhood Hits	218	Shared Neighborhood Hits	127
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

TRI34_HUMAN
NC score	0.209226 (rank : 226)	θ value	0.365318 (rank : 268)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRIM7_HUMAN
NC score	0.209218 (rank : 227)	θ value	0.365318 (rank : 269)
Query Neighborhood Hits	438	Target Neighborhood Hits	336	Shared Neighborhood Hits	173
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRI62_HUMAN
NC score	0.205959 (rank : 228)	θ value	0.47712 (rank : 278)
Query Neighborhood Hits	438	Target Neighborhood Hits	584	Shared Neighborhood Hits	188
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI15_HUMAN
NC score	0.205752 (rank : 229)	θ value	0.125558 (rank : 232)
Query Neighborhood Hits	438	Target Neighborhood Hits	395	Shared Neighborhood Hits	175
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

RHPN1_MOUSE
NC score	0.204955 (rank : 230)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	438	Target Neighborhood Hits	154	Shared Neighborhood Hits	101
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RN146_MOUSE
NC score	0.202354 (rank : 231)	θ value	0.125558 (rank : 231)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	127
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

SYP2L_HUMAN
NC score	0.202352 (rank : 232)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	438	Target Neighborhood Hits	400	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

RN146_HUMAN
NC score	0.201574 (rank : 233)	θ value	0.125558 (rank : 230)
Query Neighborhood Hits	438	Target Neighborhood Hits	162	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

TRI48_HUMAN
NC score	0.199788 (rank : 234)	θ value	6.88961 (rank : 407)
Query Neighborhood Hits	438	Target Neighborhood Hits	192	Shared Neighborhood Hits	139
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRAF2_MOUSE
NC score	0.199453 (rank : 235)	θ value	1.38821 (rank : 311)
Query Neighborhood Hits	438	Target Neighborhood Hits	394	Shared Neighborhood Hits	125
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

RN141_MOUSE
NC score	0.197907 (rank : 236)	θ value	0.0563607 (rank : 189)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	145
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_HUMAN
NC score	0.197730 (rank : 237)	θ value	0.0563607 (rank : 188)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	145
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

TRAF2_HUMAN
NC score	0.195943 (rank : 238)	θ value	1.06291 (rank : 305)
Query Neighborhood Hits	438	Target Neighborhood Hits	402	Shared Neighborhood Hits	119
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

TRAF7_MOUSE
NC score	0.195047 (rank : 239)	θ value	9.92553e-07 (rank : 66)
Query Neighborhood Hits	438	Target Neighborhood Hits	470	Shared Neighborhood Hits	145
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRI49_HUMAN
NC score	0.194258 (rank : 240)	θ value	5.27518 (rank : 385)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI38_HUMAN
NC score	0.193594 (rank : 241)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	438	Target Neighborhood Hits	373	Shared Neighborhood Hits	168
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRAF7_HUMAN
NC score	0.193477 (rank : 242)	θ value	2.21117e-06 (rank : 72)
Query Neighborhood Hits	438	Target Neighborhood Hits	482	Shared Neighborhood Hits	150
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRI56_HUMAN
NC score	0.193220 (rank : 243)	θ value	0.0252991 (rank : 164)
Query Neighborhood Hits	438	Target Neighborhood Hits	339	Shared Neighborhood Hits	167
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI17_MOUSE
NC score	0.192844 (rank : 244)	θ value	1.38821 (rank : 313)
Query Neighborhood Hits	438	Target Neighborhood Hits	620	Shared Neighborhood Hits	181
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

RIMS1_HUMAN
NC score	0.192150 (rank : 245)	θ value	0.00228821 (rank : 138)
Query Neighborhood Hits	438	Target Neighborhood Hits	437	Shared Neighborhood Hits	117
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RHPN1_HUMAN
NC score	0.191702 (rank : 246)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	438	Target Neighborhood Hits	158	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

AMFR2_HUMAN
NC score	0.190995 (rank : 247)	θ value	0.0961366 (rank : 205)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	131
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

RNF39_HUMAN
NC score	0.190505 (rank : 248)	θ value	0.21417 (rank : 245)
Query Neighborhood Hits	438	Target Neighborhood Hits	200	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

RING1_HUMAN
NC score	0.190339 (rank : 249)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	438	Target Neighborhood Hits	219	Shared Neighborhood Hits	154
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

TRI56_MOUSE
NC score	0.187964 (rank : 250)	θ value	0.0431538 (rank : 182)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	159
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

CM007_MOUSE
NC score	0.187949 (rank : 251)	θ value	0.279714 (rank : 254)
Query Neighborhood Hits	438	Target Neighborhood Hits	416	Shared Neighborhood Hits	158
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

RING1_MOUSE
NC score	0.186785 (rank : 252)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	438	Target Neighborhood Hits	220	Shared Neighborhood Hits	155
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

AMFR_MOUSE
NC score	0.185659 (rank : 253)	θ value	0.0961366 (rank : 206)
Query Neighborhood Hits	438	Target Neighborhood Hits	208	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

TRI27_HUMAN
NC score	0.185174 (rank : 254)	θ value	0.0961366 (rank : 219)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	162
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

RGS12_HUMAN
NC score	0.185086 (rank : 255)	θ value	8.99809 (rank : 421)
Query Neighborhood Hits	438	Target Neighborhood Hits	333	Shared Neighborhood Hits	106
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

TRI27_MOUSE
NC score	0.183945 (rank : 256)	θ value	0.125558 (rank : 233)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	160
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRIM1_HUMAN
NC score	0.183711 (rank : 257)	θ value	0.0431538 (rank : 183)
Query Neighborhood Hits	438	Target Neighborhood Hits	345	Shared Neighborhood Hits	169
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRI41_HUMAN
NC score	0.183533 (rank : 258)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	438	Target Neighborhood Hits	349	Shared Neighborhood Hits	153
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI18_MOUSE
NC score	0.183255 (rank : 259)	θ value	0.0961366 (rank : 218)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	159
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

RING2_HUMAN
NC score	0.182996 (rank : 260)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	438	Target Neighborhood Hits	201	Shared Neighborhood Hits	152
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
NC score	0.182972 (rank : 261)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	152
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

TRIM1_MOUSE
NC score	0.182399 (rank : 262)	θ value	0.0431538 (rank : 184)
Query Neighborhood Hits	438	Target Neighborhood Hits	361	Shared Neighborhood Hits	170
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

RAD18_MOUSE
NC score	0.182170 (rank : 263)	θ value	1.06291 (rank : 300)
Query Neighborhood Hits	438	Target Neighborhood Hits	230	Shared Neighborhood Hits	134
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

SHAN2_HUMAN
NC score	0.181624 (rank : 264)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	438	Target Neighborhood Hits	346	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

TRI18_HUMAN
NC score	0.181105 (rank : 265)	θ value	0.0961366 (rank : 217)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	161
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI34_MOUSE
NC score	0.178810 (rank : 266)	θ value	8.99809 (rank : 432)
Query Neighborhood Hits	438	Target Neighborhood Hits	332	Shared Neighborhood Hits	138
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

NOS1_MOUSE
NC score	0.178311 (rank : 267)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Z0J4, Q64208	Gene names	Nos1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

TRIM9_MOUSE
NC score	0.177352 (rank : 268)	θ value	0.0736092 (rank : 203)
Query Neighborhood Hits	438	Target Neighborhood Hits	274	Shared Neighborhood Hits	137
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

APXL_HUMAN
NC score	0.177334 (rank : 269)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	438	Target Neighborhood Hits	553	Shared Neighborhood Hits	93
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

RFWD2_MOUSE
NC score	0.177272 (rank : 270)	θ value	0.0193708 (rank : 158)
Query Neighborhood Hits	438	Target Neighborhood Hits	535	Shared Neighborhood Hits	182
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RFWD2_HUMAN
NC score	0.177220 (rank : 271)	θ value	0.0193708 (rank : 157)
Query Neighborhood Hits	438	Target Neighborhood Hits	518	Shared Neighborhood Hits	181
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

TRIM9_HUMAN
NC score	0.177051 (rank : 272)	θ value	0.0736092 (rank : 202)
Query Neighborhood Hits	438	Target Neighborhood Hits	294	Shared Neighborhood Hits	139
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

RAD18_HUMAN
NC score	0.175557 (rank : 273)	θ value	0.47712 (rank : 276)
Query Neighborhood Hits	438	Target Neighborhood Hits	284	Shared Neighborhood Hits	140
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

TRIM2_HUMAN
NC score	0.175096 (rank : 274)	θ value	8.99809 (rank : 433)
Query Neighborhood Hits	438	Target Neighborhood Hits	330	Shared Neighborhood Hits	185
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM2_MOUSE
NC score	0.173858 (rank : 275)	θ value	8.99809 (rank : 434)
Query Neighborhood Hits	438	Target Neighborhood Hits	331	Shared Neighborhood Hits	184
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

SYNP2_MOUSE
NC score	0.173456 (rank : 276)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	438	Target Neighborhood Hits	252	Shared Neighborhood Hits	96
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

TRIM3_MOUSE
NC score	0.173385 (rank : 277)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	438	Target Neighborhood Hits	351	Shared Neighborhood Hits	176
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRI32_MOUSE
NC score	0.173316 (rank : 278)	θ value	1.81305 (rank : 322)
Query Neighborhood Hits	438	Target Neighborhood Hits	271	Shared Neighborhood Hits	144
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI32_HUMAN
NC score	0.173271 (rank : 279)	θ value	1.81305 (rank : 321)
Query Neighborhood Hits	438	Target Neighborhood Hits	264	Shared Neighborhood Hits	144
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI37_MOUSE
NC score	0.172708 (rank : 280)	θ value	0.279714 (rank : 261)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	140
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI37_HUMAN
NC score	0.172530 (rank : 281)	θ value	0.279714 (rank : 260)
Query Neighborhood Hits	438	Target Neighborhood Hits	307	Shared Neighborhood Hits	140
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

ZN364_HUMAN
NC score	0.171857 (rank : 282)	θ value	0.000602161 (rank : 121)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y4L5, Q5T2V9, Q7Z2J2	Gene names	ZNF364, RNF115
Domain Architecture	No domain graphic available
Description	Zinc finger protein 364 (Rabring 7) (RING finger protein 115).

CM007_HUMAN
NC score	0.171324 (rank : 283)	θ value	0.47712 (rank : 274)
Query Neighborhood Hits	438	Target Neighborhood Hits	422	Shared Neighborhood Hits	154
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

KGUA_MOUSE
NC score	0.170614 (rank : 284)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	438	Target Neighborhood Hits	45	Shared Neighborhood Hits	24
SwissProt Accessions	Q64520	Gene names	Guk1, Gmk
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

TRIM3_HUMAN
NC score	0.170602 (rank : 285)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	438	Target Neighborhood Hits	357	Shared Neighborhood Hits	174
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

KGUA_HUMAN
NC score	0.170130 (rank : 286)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	438	Target Neighborhood Hits	41	Shared Neighborhood Hits	24
SwissProt Accessions	Q16774	Gene names	GUK1, GMK
Domain Architecture
Description	Guanylate kinase (EC 2.7.4.8) (GMP kinase).

PCGF6_HUMAN
NC score	0.166877 (rank : 287)	θ value	0.0563607 (rank : 187)
Query Neighborhood Hits	438	Target Neighborhood Hits	178	Shared Neighborhood Hits	117
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

PCGF6_MOUSE
NC score	0.166603 (rank : 288)	θ value	0.0431538 (rank : 172)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	115
SwissProt Accessions	Q99NA9	Gene names	Pcgf6, Mblr, Rnf134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

SHAN2_MOUSE
NC score	0.163831 (rank : 289)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	438	Target Neighborhood Hits	446	Shared Neighborhood Hits	99
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SIAH2_HUMAN
NC score	0.159317 (rank : 290)	θ value	0.163984 (rank : 239)
Query Neighborhood Hits	438	Target Neighborhood Hits	94	Shared Neighborhood Hits	50
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
NC score	0.158501 (rank : 291)	θ value	0.163984 (rank : 240)
Query Neighborhood Hits	438	Target Neighborhood Hits	101	Shared Neighborhood Hits	49
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

CBL_HUMAN
NC score	0.156852 (rank : 292)	θ value	0.0736092 (rank : 196)
Query Neighborhood Hits	438	Target Neighborhood Hits	353	Shared Neighborhood Hits	153
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

RN126_MOUSE
NC score	0.156785 (rank : 293)	θ value	0.0431538 (rank : 176)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	90
SwissProt Accessions	Q91YL2	Gene names	Rnf126
Domain Architecture	No domain graphic available
Description	RING finger protein 126.

ZN364_MOUSE
NC score	0.155995 (rank : 294)	θ value	0.00509761 (rank : 144)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D0C1, Q8R5A1, Q9D885	Gene names	Znf364, Zfp364
Domain Architecture
Description	Zinc finger protein 364 (Rabring 7).

CBL_MOUSE
NC score	0.155786 (rank : 295)	θ value	0.0736092 (rank : 197)
Query Neighborhood Hits	438	Target Neighborhood Hits	426	Shared Neighborhood Hits	159
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

TRI63_MOUSE
NC score	0.153900 (rank : 296)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	438	Target Neighborhood Hits	240	Shared Neighborhood Hits	130
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

CBLC_HUMAN
NC score	0.153349 (rank : 297)	θ value	0.0563607 (rank : 186)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	119
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

CBLC_MOUSE
NC score	0.153193 (rank : 298)	θ value	0.21417 (rank : 243)
Query Neighborhood Hits	438	Target Neighborhood Hits	186	Shared Neighborhood Hits	126
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

TRI54_HUMAN
NC score	0.151800 (rank : 299)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	438	Target Neighborhood Hits	209	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

PDLI3_HUMAN
NC score	0.151293 (rank : 300)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	85
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

TRI54_MOUSE
NC score	0.150545 (rank : 301)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	130
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

SMRA3_HUMAN
NC score	0.149870 (rank : 302)	θ value	0.62314 (rank : 289)
Query Neighborhood Hits	438	Target Neighborhood Hits	265	Shared Neighborhood Hits	164
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

TRI63_HUMAN
NC score	0.149578 (rank : 303)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	438	Target Neighborhood Hits	298	Shared Neighborhood Hits	133
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

RN126_HUMAN
NC score	0.149561 (rank : 304)	θ value	0.21417 (rank : 244)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BV68, Q9NWX1	Gene names	RNF126
Domain Architecture	No domain graphic available
Description	RING finger protein 126.

CBLB_HUMAN
NC score	0.149295 (rank : 305)	θ value	0.0736092 (rank : 194)
Query Neighborhood Hits	438	Target Neighborhood Hits	261	Shared Neighborhood Hits	142
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

TRI55_HUMAN
NC score	0.148928 (rank : 306)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	438	Target Neighborhood Hits	292	Shared Neighborhood Hits	128
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

CBLB_MOUSE
NC score	0.148304 (rank : 307)	θ value	0.0736092 (rank : 195)
Query Neighborhood Hits	438	Target Neighborhood Hits	277	Shared Neighborhood Hits	141
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

SMRA3_MOUSE
NC score	0.148294 (rank : 308)	θ value	1.06291 (rank : 304)
Query Neighborhood Hits	438	Target Neighborhood Hits	267	Shared Neighborhood Hits	163
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

TRI46_HUMAN
NC score	0.148008 (rank : 309)	θ value	4.03905 (rank : 364)
Query Neighborhood Hits	438	Target Neighborhood Hits	291	Shared Neighborhood Hits	137
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
NC score	0.147895 (rank : 310)	θ value	4.03905 (rank : 365)
Query Neighborhood Hits	438	Target Neighborhood Hits	287	Shared Neighborhood Hits	135
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

PDLI1_MOUSE
NC score	0.142476 (rank : 311)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	72
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PDLI1_HUMAN
NC score	0.141976 (rank : 312)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	438	Target Neighborhood Hits	242	Shared Neighborhood Hits	75
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RN169_HUMAN
NC score	0.141524 (rank : 313)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	438	Target Neighborhood Hits	203	Shared Neighborhood Hits	102
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RIMS2_HUMAN
NC score	0.140387 (rank : 314)	θ value	8.99809 (rank : 422)
Query Neighborhood Hits	438	Target Neighborhood Hits	342	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

GIPC1_MOUSE
NC score	0.140374 (rank : 315)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	438	Target Neighborhood Hits	92	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z0G0	Gene names	Gipc1, Gipc, Rgs19ip1, Semcap1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Synectin) (SemaF cytoplasmic domain-associated protein 1) (SEMCAP-1).

PDLI4_MOUSE
NC score	0.139728 (rank : 316)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	84
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

RIMS2_MOUSE
NC score	0.138648 (rank : 317)	θ value	8.99809 (rank : 423)
Query Neighborhood Hits	438	Target Neighborhood Hits	376	Shared Neighborhood Hits	102
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

PCLO_MOUSE
NC score	0.138389 (rank : 318)	θ value	0.279714 (rank : 256)
Query Neighborhood Hits	438	Target Neighborhood Hits	2275	Shared Neighborhood Hits	157
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDLI4_HUMAN
NC score	0.137825 (rank : 319)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	438	Target Neighborhood Hits	245	Shared Neighborhood Hits	82
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDLI3_MOUSE
NC score	0.136555 (rank : 320)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	81
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

SYP2L_MOUSE
NC score	0.136134 (rank : 321)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	438	Target Neighborhood Hits	289	Shared Neighborhood Hits	80
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TOPRS_MOUSE
NC score	0.135304 (rank : 322)	θ value	5.27518 (rank : 384)
Query Neighborhood Hits	438	Target Neighborhood Hits	263	Shared Neighborhood Hits	127
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TOPRS_HUMAN
NC score	0.134627 (rank : 323)	θ value	5.27518 (rank : 383)
Query Neighborhood Hits	438	Target Neighborhood Hits	286	Shared Neighborhood Hits	130
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

SIA1A_MOUSE
NC score	0.134464 (rank : 324)	θ value	0.0252991 (rank : 163)
Query Neighborhood Hits	438	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIAH1_HUMAN
NC score	0.133857 (rank : 325)	θ value	0.0330416 (rank : 169)
Query Neighborhood Hits	438	Target Neighborhood Hits	72	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

UHRF2_MOUSE
NC score	0.132483 (rank : 326)	θ value	8.99809 (rank : 438)
Query Neighborhood Hits	438	Target Neighborhood Hits	275	Shared Neighborhood Hits	139
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

UHRF2_HUMAN
NC score	0.132001 (rank : 327)	θ value	8.99809 (rank : 437)
Query Neighborhood Hits	438	Target Neighborhood Hits	269	Shared Neighborhood Hits	142
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

GIPC1_HUMAN
NC score	0.131387 (rank : 328)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	438	Target Neighborhood Hits	91	Shared Neighborhood Hits	76
SwissProt Accessions	O14908, Q9BTC9	Gene names	GIPC1, C19orf3, GIPC, RGS19IP1
Domain Architecture
Description	PDZ domain-containing protein GIPC1 (RGS19-interacting protein 1) (GAIP C-terminus-interacting protein) (RGS-GAIP-interacting protein) (Tax interaction protein 2) (TIP-2).

MEFV_HUMAN
NC score	0.131187 (rank : 329)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	438	Target Neighborhood Hits	431	Shared Neighborhood Hits	92
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

TRI36_HUMAN
NC score	0.130492 (rank : 330)	θ value	6.88961 (rank : 405)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NQ86	Gene names	TRIM36, RBCC728, RNF98
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Zinc-binding protein Rbcc728) (RING finger protein 98).

PCGF2_HUMAN
NC score	0.130458 (rank : 331)	θ value	1.06291 (rank : 298)
Query Neighborhood Hits	438	Target Neighborhood Hits	222	Shared Neighborhood Hits	118
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCGF2_MOUSE
NC score	0.130409 (rank : 332)	θ value	1.06291 (rank : 299)
Query Neighborhood Hits	438	Target Neighborhood Hits	213	Shared Neighborhood Hits	114
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

DTX3_MOUSE
NC score	0.130072 (rank : 333)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	438	Target Neighborhood Hits	202	Shared Neighborhood Hits	143
SwissProt Accessions	Q80V91, Q9ER06	Gene names	Dtx3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3) (mDTX3).

SIA1B_MOUSE
NC score	0.130024 (rank : 334)	θ value	0.0431538 (rank : 177)
Query Neighborhood Hits	438	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SYNP2_HUMAN
NC score	0.129936 (rank : 335)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	438	Target Neighborhood Hits	323	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

DTX3_HUMAN
NC score	0.129135 (rank : 336)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	438	Target Neighborhood Hits	198	Shared Neighborhood Hits	141
SwissProt Accessions	Q8N9I9, Q8NAU6, Q8NDS8	Gene names	DTX3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3).

RN183_HUMAN
NC score	0.128060 (rank : 337)	θ value	2.36792 (rank : 326)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	89
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

TRI36_MOUSE
NC score	0.127742 (rank : 338)	θ value	6.88961 (rank : 406)
Query Neighborhood Hits	438	Target Neighborhood Hits	266	Shared Neighborhood Hits	129
SwissProt Accessions	Q80WG7, Q7TNM1	Gene names	Trim36
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 36 (Haprin) (Acrosome RBCC protein).

RN165_HUMAN
NC score	0.126972 (rank : 339)	θ value	8.99809 (rank : 426)
Query Neighborhood Hits	438	Target Neighborhood Hits	151	Shared Neighborhood Hits	81
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

TRI14_HUMAN
NC score	0.126865 (rank : 340)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	75
SwissProt Accessions	Q14142, Q9BRD8, Q9C020	Gene names	TRIM14, KIAA0129
Domain Architecture
Description	Tripartite motif-containing protein 14.

TRI14_MOUSE
NC score	0.126571 (rank : 341)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	438	Target Neighborhood Hits	137	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

PTN4_HUMAN
NC score	0.125284 (rank : 342)	θ value	0.279714 (rank : 258)
Query Neighborhood Hits	438	Target Neighborhood Hits	303	Shared Neighborhood Hits	99
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

RFPL3_HUMAN
NC score	0.124161 (rank : 343)	θ value	8.99809 (rank : 420)
Query Neighborhood Hits	438	Target Neighborhood Hits	134	Shared Neighborhood Hits	93
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

SHAN1_HUMAN
NC score	0.123446 (rank : 344)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	438	Target Neighborhood Hits	1041	Shared Neighborhood Hits	135
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

TRI16_MOUSE
NC score	0.122326 (rank : 345)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PP9, Q7TPY6, Q8C332, Q8C6V0	Gene names	Trim16, Ebbp
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

PCGF4_HUMAN
NC score	0.121981 (rank : 346)	θ value	2.36792 (rank : 324)
Query Neighborhood Hits	438	Target Neighborhood Hits	161	Shared Neighborhood Hits	118
SwissProt Accessions	P35226, Q16030, Q96F37	Gene names	PCGF4, BMI1, RNF51
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1) (RING finger protein 51).

PCGF4_MOUSE
NC score	0.121820 (rank : 347)	θ value	2.36792 (rank : 325)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	116
SwissProt Accessions	P25916	Gene names	Pcgf4, Bmi-1, Bmi1
Domain Architecture
Description	Polycomb group RING finger protein 4 (Polycomb complex protein BMI-1).

UHRF1_HUMAN
NC score	0.121413 (rank : 348)	θ value	2.36792 (rank : 333)
Query Neighborhood Hits	438	Target Neighborhood Hits	272	Shared Neighborhood Hits	142
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

RFPL2_HUMAN
NC score	0.121002 (rank : 349)	θ value	8.99809 (rank : 419)
Query Neighborhood Hits	438	Target Neighborhood Hits	126	Shared Neighborhood Hits	91
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

PTN3_HUMAN
NC score	0.120332 (rank : 350)	θ value	0.163984 (rank : 238)
Query Neighborhood Hits	438	Target Neighborhood Hits	258	Shared Neighborhood Hits	95
SwissProt Accessions	P26045	Gene names	PTPN3, PTPH1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1).

TRI16_HUMAN
NC score	0.119600 (rank : 351)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

BSPRY_MOUSE
NC score	0.118304 (rank : 352)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	73
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

RFPL1_HUMAN
NC score	0.118231 (rank : 353)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	84
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

DZIP3_HUMAN
NC score	0.118109 (rank : 354)	θ value	0.62314 (rank : 283)
Query Neighborhood Hits	438	Target Neighborhood Hits	399	Shared Neighborhood Hits	94
SwissProt Accessions	Q86Y13, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9	Gene names	DZIP3, KIAA0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138).

HTRA3_HUMAN
NC score	0.117100 (rank : 355)	θ value	0.125558 (rank : 224)
Query Neighborhood Hits	438	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

RN183_MOUSE
NC score	0.116960 (rank : 356)	θ value	2.36792 (rank : 327)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	85
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

HTRA3_MOUSE
NC score	0.116713 (rank : 357)	θ value	0.163984 (rank : 236)
Query Neighborhood Hits	438	Target Neighborhood Hits	156	Shared Neighborhood Hits	64
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

NHLC1_MOUSE
NC score	0.115019 (rank : 358)	θ value	0.813845 (rank : 292)
Query Neighborhood Hits	438	Target Neighborhood Hits	103	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

GIPC2_HUMAN
NC score	0.114633 (rank : 359)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	438	Target Neighborhood Hits	93	Shared Neighborhood Hits	83
SwissProt Accessions	Q8TF65, Q8IYD3, Q9NXS7	Gene names	GIPC2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2.

MEFV_MOUSE
NC score	0.114327 (rank : 360)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	438	Target Neighborhood Hits	236	Shared Neighborhood Hits	80
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

DZIP3_MOUSE
NC score	0.114253 (rank : 361)	θ value	1.38821 (rank : 308)
Query Neighborhood Hits	438	Target Neighborhood Hits	414	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TPV2, Q80TU4, Q8BYK7	Gene names	Dzip3, Kiaa0675
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (DAZ-interacting protein 3 homolog).

PDZD6_HUMAN
NC score	0.113861 (rank : 362)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ULD6, Q4W5I8, Q86V55	Gene names	PDZD6, KIAA1284, PDZK6
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 6.

LDB3_MOUSE
NC score	0.113655 (rank : 363)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	438	Target Neighborhood Hits	510	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JKS4, Q6A038, Q811P2, Q811P3, Q811P4, Q811P5, Q9D130, Q9JKS3, Q9R0Z1, Q9WVH1, Q9WVH2	Gene names	Ldb3, Kiaa0613
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher) (Protein oracle).

TRI29_MOUSE
NC score	0.113320 (rank : 364)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	438	Target Neighborhood Hits	306	Shared Neighborhood Hits	87
SwissProt Accessions	Q8R2Q0, Q8CEE2, Q922Y3, Q99PN5, Q9CSC9	Gene names	Trim29
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29.

TRI44_MOUSE
NC score	0.112753 (rank : 365)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	81
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

BSPRY_HUMAN
NC score	0.111929 (rank : 366)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	438	Target Neighborhood Hits	115	Shared Neighborhood Hits	68
SwissProt Accessions	Q5W0U4, Q96DJ2, Q9H4E4, Q9NXN0	Gene names	BSPRY
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

PDLI5_MOUSE
NC score	0.111696 (rank : 367)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	438	Target Neighborhood Hits	287	Shared Neighborhood Hits	87
SwissProt Accessions	Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2	Gene names	Pdlim5, Enh
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

LDB3_HUMAN
NC score	0.111650 (rank : 368)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	438	Target Neighborhood Hits	497	Shared Neighborhood Hits	86
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

ERMAP_HUMAN
NC score	0.111354 (rank : 369)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	56
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

UHRF1_MOUSE
NC score	0.110697 (rank : 370)	θ value	5.27518 (rank : 386)
Query Neighborhood Hits	438	Target Neighborhood Hits	278	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VDF2, Q8C6F1, Q8VIA1, Q9Z1H6	Gene names	Uhrf1, Np95
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Nuclear zinc finger protein Np95) (Nuclear protein 95).

PDLI5_HUMAN
NC score	0.110685 (rank : 371)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	438	Target Neighborhood Hits	322	Shared Neighborhood Hits	86
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

TRI29_HUMAN
NC score	0.110604 (rank : 372)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	438	Target Neighborhood Hits	273	Shared Neighborhood Hits	84
SwissProt Accessions	Q14134, Q96AA9, Q9BZY7	Gene names	TRIM29, ATDC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29 (Ataxia-telangiectasia group D- associated protein).

TRI44_HUMAN
NC score	0.110089 (rank : 373)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	438	Target Neighborhood Hits	393	Shared Neighborhood Hits	87
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

TRAF1_MOUSE
NC score	0.109057 (rank : 374)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	438	Target Neighborhood Hits	52	Shared Neighborhood Hits	13
SwissProt Accessions	P39428	Gene names	Traf1
Domain Architecture
Description	TNF receptor-associated factor 1.

TRAF1_HUMAN
NC score	0.108543 (rank : 375)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	438	Target Neighborhood Hits	65	Shared Neighborhood Hits	18
SwissProt Accessions	Q13077, Q8NF13	Gene names	TRAF1, EBI6
Domain Architecture
Description	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6).

TIAM1_HUMAN
NC score	0.104077 (rank : 376)	θ value	2.44474e-05 (rank : 90)
Query Neighborhood Hits	438	Target Neighborhood Hits	225	Shared Neighborhood Hits	63
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CNKR2_MOUSE
NC score	0.103474 (rank : 377)	θ value	0.62314 (rank : 282)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	52
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.103443 (rank : 378)	θ value	0.62314 (rank : 281)
Query Neighborhood Hits	438	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ERMAP_MOUSE
NC score	0.102490 (rank : 379)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

PDLI7_HUMAN
NC score	0.101926 (rank : 380)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	438	Target Neighborhood Hits	547	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

BIRC7_HUMAN
NC score	0.100962 (rank : 381)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	124
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

RN103_MOUSE
NC score	0.100907 (rank : 382)	θ value	1.06291 (rank : 302)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	Q9R1W3, O08670, O08883	Gene names	Rnf103, Zfp103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103) (Zfp-103) (KF-1) (mKF-1).

BT1A1_MOUSE
NC score	0.098848 (rank : 383)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	438	Target Neighborhood Hits	252	Shared Neighborhood Hits	59
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

RN103_HUMAN
NC score	0.097926 (rank : 384)	θ value	1.06291 (rank : 301)
Query Neighborhood Hits	438	Target Neighborhood Hits	153	Shared Neighborhood Hits	80
SwissProt Accessions	O00237, Q8IVB9	Gene names	RNF103
Domain Architecture	No domain graphic available
Description	RING finger protein 103 (Zinc finger protein 103 homolog) (Zfp-103) (KF-1) (hKF-1).

BT3A3_HUMAN
NC score	0.097746 (rank : 385)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	438	Target Neighborhood Hits	233	Shared Neighborhood Hits	58
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BT1A1_HUMAN
NC score	0.096770 (rank : 386)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	438	Target Neighborhood Hits	322	Shared Neighborhood Hits	57
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

SPRY4_MOUSE
NC score	0.096716 (rank : 387)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	55
SwissProt Accessions	Q91WK1, Q8BUS6, Q9D651	Gene names	Spryd4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

BTNL3_HUMAN
NC score	0.096320 (rank : 388)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	438	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

BT3A1_HUMAN
NC score	0.096199 (rank : 389)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	438	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

BT2A2_HUMAN
NC score	0.095873 (rank : 390)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	438	Target Neighborhood Hits	191	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

RC3H1_MOUSE
NC score	0.095871 (rank : 391)	θ value	1.81305 (rank : 320)
Query Neighborhood Hits	438	Target Neighborhood Hits	244	Shared Neighborhood Hits	115
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

PDLI7_MOUSE
NC score	0.094974 (rank : 392)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	72
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

GOLI_MOUSE
NC score	0.094971 (rank : 393)	θ value	5.27518 (rank : 370)
Query Neighborhood Hits	438	Target Neighborhood Hits	134	Shared Neighborhood Hits	71
SwissProt Accessions	Q8VEM1, Q80VL7, Q9QZQ6	Gene names	Rnf130, G1rp
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130) (G1-related zinc finger protein).

BTNL9_HUMAN
NC score	0.094965 (rank : 394)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	438	Target Neighborhood Hits	125	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UXG8, Q6P660, Q96DM5	Gene names	BTNL9
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 9 precursor.

SPRY4_HUMAN
NC score	0.094764 (rank : 395)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	438	Target Neighborhood Hits	79	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WW59	Gene names	SPRYD4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

RC3H1_HUMAN
NC score	0.094526 (rank : 396)	θ value	1.81305 (rank : 319)
Query Neighborhood Hits	438	Target Neighborhood Hits	433	Shared Neighborhood Hits	124
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

PJA1_HUMAN
NC score	0.094322 (rank : 397)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	80
SwissProt Accessions	Q8NG27, Q8NG28, Q9HAC1	Gene names	PJA1, RNF70
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-) (RING finger protein 70).

GOLI_HUMAN
NC score	0.093700 (rank : 398)	θ value	5.27518 (rank : 369)
Query Neighborhood Hits	438	Target Neighborhood Hits	137	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XS8, Q641P9, Q6P177, Q7L2U2, Q9P0J9	Gene names	RNF130
Domain Architecture	No domain graphic available
Description	Goliath homolog precursor (RING finger protein 130).

TRI42_HUMAN
NC score	0.093440 (rank : 399)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	438	Target Neighborhood Hits	283	Shared Neighborhood Hits	97
SwissProt Accessions	Q8IWZ5, Q8N832, Q8NDL3	Gene names	TRIM42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

PDZD8_HUMAN
NC score	0.093101 (rank : 400)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

TRI42_MOUSE
NC score	0.092416 (rank : 401)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	102
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

BTNL8_HUMAN
NC score	0.092105 (rank : 402)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	438	Target Neighborhood Hits	177	Shared Neighborhood Hits	55
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

BT2A1_HUMAN
NC score	0.092022 (rank : 403)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	438	Target Neighborhood Hits	185	Shared Neighborhood Hits	57
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

MGRN1_HUMAN
NC score	0.091783 (rank : 404)	θ value	1.81305 (rank : 316)
Query Neighborhood Hits	438	Target Neighborhood Hits	192	Shared Neighborhood Hits	97
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

PRAX_MOUSE
NC score	0.091250 (rank : 405)	θ value	6.88961 (rank : 402)
Query Neighborhood Hits	438	Target Neighborhood Hits	199	Shared Neighborhood Hits	40
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

RN167_MOUSE
NC score	0.091085 (rank : 406)	θ value	3.0926 (rank : 345)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	84
SwissProt Accessions	Q91XF4, Q3U4S5	Gene names	Rnf167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

PML_MOUSE
NC score	0.090988 (rank : 407)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	438	Target Neighborhood Hits	246	Shared Neighborhood Hits	104
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

RBBP6_MOUSE
NC score	0.090739 (rank : 408)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	438	Target Neighborhood Hits	1014	Shared Neighborhood Hits	155
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

BT2A3_HUMAN
NC score	0.090517 (rank : 409)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	438	Target Neighborhood Hits	195	Shared Neighborhood Hits	53
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

PJA1_MOUSE
NC score	0.090372 (rank : 410)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	438	Target Neighborhood Hits	145	Shared Neighborhood Hits	76
SwissProt Accessions	O55176, Q8CFU2, Q99MJ1, Q99MJ2, Q99MJ3, Q9DB04	Gene names	Pja1
Domain Architecture
Description	Ubiquitin protein ligase Praja1 (EC 6.3.2.-).

MGRN1_MOUSE
NC score	0.090351 (rank : 411)	θ value	1.38821 (rank : 310)
Query Neighborhood Hits	438	Target Neighborhood Hits	149	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

RN139_MOUSE
NC score	0.088890 (rank : 412)	θ value	8.99809 (rank : 425)
Query Neighborhood Hits	438	Target Neighborhood Hits	131	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TMV1, Q8BZU9	Gene names	Rnf139
Domain Architecture	No domain graphic available
Description	RING finger protein 139.

PML_HUMAN
NC score	0.088181 (rank : 413)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	438	Target Neighborhood Hits	248	Shared Neighborhood Hits	98
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

NHLC1_HUMAN
NC score	0.086819 (rank : 414)	θ value	4.03905 (rank : 354)
Query Neighborhood Hits	438	Target Neighborhood Hits	91	Shared Neighborhood Hits	69
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

RN167_HUMAN
NC score	0.086648 (rank : 415)	θ value	3.0926 (rank : 344)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H6Y7, Q6XYE0, Q8NDC1, Q9Y3V1	Gene names	RNF167
Domain Architecture	No domain graphic available
Description	RING finger protein 167 precursor.

BRE1A_MOUSE
NC score	0.085664 (rank : 416)	θ value	0.47712 (rank : 273)
Query Neighborhood Hits	438	Target Neighborhood Hits	1025	Shared Neighborhood Hits	165
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

RBBP6_HUMAN
NC score	0.084476 (rank : 417)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	438	Target Neighborhood Hits	1135	Shared Neighborhood Hits	161
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RN139_HUMAN
NC score	0.084376 (rank : 418)	θ value	8.99809 (rank : 424)
Query Neighborhood Hits	438	Target Neighborhood Hits	130	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WU17, O75485, Q7LDL3	Gene names	RNF139, TRC8
Domain Architecture	No domain graphic available
Description	RING finger protein 139 (Translocation in renal carcinoma on chromosome 8).

BRE1A_HUMAN
NC score	0.083762 (rank : 419)	θ value	0.47712 (rank : 272)
Query Neighborhood Hits	438	Target Neighborhood Hits	1071	Shared Neighborhood Hits	170
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

RNF24_HUMAN
NC score	0.082888 (rank : 420)	θ value	2.36792 (rank : 328)
Query Neighborhood Hits	438	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Y225, Q9UMH1	Gene names	RNF24
Domain Architecture
Description	RING finger protein 24.

BRE1B_MOUSE
NC score	0.082576 (rank : 421)	θ value	0.813845 (rank : 291)
Query Neighborhood Hits	438	Target Neighborhood Hits	970	Shared Neighborhood Hits	162
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

RNF24_MOUSE
NC score	0.082289 (rank : 422)	θ value	3.0926 (rank : 346)
Query Neighborhood Hits	438	Target Neighborhood Hits	124	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BGI1	Gene names	Rnf24
Domain Architecture	No domain graphic available
Description	RING finger protein 24.

HTRA4_HUMAN
NC score	0.082182 (rank : 423)	θ value	0.125558 (rank : 225)
Query Neighborhood Hits	438	Target Neighborhood Hits	119	Shared Neighborhood Hits	35
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

BRE1B_HUMAN
NC score	0.081401 (rank : 424)	θ value	0.813845 (rank : 290)
Query Neighborhood Hits	438	Target Neighborhood Hits	1040	Shared Neighborhood Hits	165
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

TIAM1_MOUSE
NC score	0.079507 (rank : 425)	θ value	0.0961366 (rank : 214)
Query Neighborhood Hits	438	Target Neighborhood Hits	205	Shared Neighborhood Hits	49
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CSKP_HUMAN
NC score	0.078562 (rank : 426)	θ value	6.88961 (rank : 393)
Query Neighborhood Hits	438	Target Neighborhood Hits	1022	Shared Neighborhood Hits	110
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

HTRA1_HUMAN
NC score	0.078354 (rank : 427)	θ value	1.06291 (rank : 297)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	47
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

RN122_MOUSE
NC score	0.077670 (rank : 428)	θ value	5.27518 (rank : 377)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BP31, Q80VA7, Q8BGD3	Gene names	Rnf122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

CSKP_MOUSE
NC score	0.077249 (rank : 429)	θ value	6.88961 (rank : 394)
Query Neighborhood Hits	438	Target Neighborhood Hits	1027	Shared Neighborhood Hits	111
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

LMO7_HUMAN
NC score	0.077092 (rank : 430)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	438	Target Neighborhood Hits	507	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

RN122_HUMAN
NC score	0.076860 (rank : 431)	θ value	5.27518 (rank : 376)
Query Neighborhood Hits	438	Target Neighborhood Hits	121	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H9V4, Q52LK3	Gene names	RNF122
Domain Architecture	No domain graphic available
Description	RING finger protein 122.

TRAIP_HUMAN
NC score	0.076151 (rank : 432)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	438	Target Neighborhood Hits	780	Shared Neighborhood Hits	136
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

CAR11_HUMAN
NC score	0.076057 (rank : 433)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	438	Target Neighborhood Hits	690	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

HTRA1_MOUSE
NC score	0.075669 (rank : 434)	θ value	3.0926 (rank : 339)
Query Neighborhood Hits	438	Target Neighborhood Hits	140	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

DTX3L_HUMAN
NC score	0.074958 (rank : 435)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	438	Target Neighborhood Hits	187	Shared Neighborhood Hits	107
SwissProt Accessions	Q8TDB6	Gene names	DTX3L, BBAP
Domain Architecture
Description	Protein deltex 3-like protein (B-lymphoma- and BAL-associated protein) (Rhysin-2) (Rhysin2).

TRI45_HUMAN
NC score	0.074295 (rank : 436)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H8W5, Q5T2K4, Q5T2K5, Q8IYV6	Gene names	TRIM45, RNF99
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45 (RING finger protein 99).

RNF32_HUMAN
NC score	0.072445 (rank : 437)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	438	Target Neighborhood Hits	133	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H0A6, Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9Y6U1	Gene names	RNF32
Domain Architecture	No domain graphic available
Description	RING finger protein 32.

RNF13_MOUSE
NC score	0.072438 (rank : 438)	θ value	6.88961 (rank : 404)
Query Neighborhood Hits	438	Target Neighborhood Hits	164	Shared Neighborhood Hits	77
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

TRI45_MOUSE
NC score	0.070298 (rank : 439)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	82
SwissProt Accessions	Q6PFY8, Q8BVT5	Gene names	Trim45
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 45.

TRAIP_MOUSE
NC score	0.070245 (rank : 440)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	438	Target Neighborhood Hits	745	Shared Neighborhood Hits	127
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

BARD1_MOUSE
NC score	0.068993 (rank : 441)	θ value	0.125558 (rank : 221)
Query Neighborhood Hits	438	Target Neighborhood Hits	411	Shared Neighborhood Hits	80
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

RN152_MOUSE
NC score	0.067813 (rank : 442)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	438	Target Neighborhood Hits	109	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

BARD1_HUMAN
NC score	0.067615 (rank : 443)	θ value	0.21417 (rank : 242)
Query Neighborhood Hits	438	Target Neighborhood Hits	427	Shared Neighborhood Hits	92
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

RNF32_MOUSE
NC score	0.066868 (rank : 444)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	438	Target Neighborhood Hits	129	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JIT1, Q9D9X0, Q9DAJ3	Gene names	Rnf32, Lmbr2
Domain Architecture	No domain graphic available
Description	RING finger protein 32 (Limb region protein 2).

LRRC1_MOUSE
NC score	0.065763 (rank : 445)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	438	Target Neighborhood Hits	281	Shared Neighborhood Hits	8
SwissProt Accessions	Q80VQ1, Q3UI50, Q8BKR1, Q8BUS9	Gene names	Lrrc1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1.

LRRC1_HUMAN
NC score	0.065473 (rank : 446)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	438	Target Neighborhood Hits	282	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BTT6, Q9HAC0, Q9NVF1	Gene names	LRRC1, LANO
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 1 (LAP and no PDZ protein) (LANO adapter protein).

MY18A_MOUSE
NC score	0.065154 (rank : 447)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	438	Target Neighborhood Hits	1989	Shared Neighborhood Hits	205
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RN152_HUMAN
NC score	0.064455 (rank : 448)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	438	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

TTC3_HUMAN
NC score	0.064203 (rank : 449)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	438	Target Neighborhood Hits	664	Shared Neighborhood Hits	96
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

GIPC2_MOUSE
NC score	0.064017 (rank : 450)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	438	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z2H7, Q9CVG2	Gene names	Gipc2, Semcap2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC2 (SemaF cytoplasmic domain- associated protein 2) (SEMCAP-2).

RNF13_HUMAN
NC score	0.063733 (rank : 451)	θ value	8.99809 (rank : 427)
Query Neighborhood Hits	438	Target Neighborhood Hits	147	Shared Neighborhood Hits	68
SwissProt Accessions	O43567	Gene names	RNF13, RZF
Domain Architecture
Description	RING finger protein 13.

LRSM1_MOUSE
NC score	0.063184 (rank : 452)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	438	Target Neighborhood Hits	874	Shared Neighborhood Hits	119
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

RN133_HUMAN
NC score	0.063172 (rank : 453)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	438	Target Neighborhood Hits	108	Shared Neighborhood Hits	53
SwissProt Accessions	Q8WVZ7, Q8N7G7	Gene names	RNF133
Domain Architecture	No domain graphic available
Description	RING finger protein 133.

GIPC3_HUMAN
NC score	0.062651 (rank : 454)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	438	Target Neighborhood Hits	52	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TF64, O75227	Gene names	GIPC3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3.

CAR14_HUMAN
NC score	0.062458 (rank : 455)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	438	Target Neighborhood Hits	449	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

LRSM1_HUMAN
NC score	0.062351 (rank : 456)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	438	Target Neighborhood Hits	1078	Shared Neighborhood Hits	125
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

PRAX_HUMAN
NC score	0.062221 (rank : 457)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	438	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

MY18A_HUMAN
NC score	0.062188 (rank : 458)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	438	Target Neighborhood Hits	1929	Shared Neighborhood Hits	214
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

BICD2_HUMAN
NC score	0.061960 (rank : 459)	θ value	0.00134147 (rank : 128)
Query Neighborhood Hits	438	Target Neighborhood Hits	856	Shared Neighborhood Hits	68
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

RNF11_HUMAN
NC score	0.061700 (rank : 460)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y3C5	Gene names	RNF11
Domain Architecture
Description	RING finger protein 11 (Sid 1669).

RNF11_MOUSE
NC score	0.061438 (rank : 461)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QYK7, Q9EQI1	Gene names	Rnf11, N4wbp2, Sid1669
Domain Architecture
Description	RING finger protein 11 (NEDD4 WW domain-binding protein 2) (Sid 1669).

GIPC3_MOUSE
NC score	0.060941 (rank : 462)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	438	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q8R5M0	Gene names	Gipc3, Rgs19ip3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein GIPC3 (Regulator of G-protein signaling 19-interacting protein 3).

TIF1G_MOUSE
NC score	0.060902 (rank : 463)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	438	Target Neighborhood Hits	498	Shared Neighborhood Hits	112
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TIF1G_HUMAN
NC score	0.060694 (rank : 464)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	438	Target Neighborhood Hits	410	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

BICD2_MOUSE
NC score	0.060225 (rank : 465)	θ value	0.00134147 (rank : 129)
Query Neighborhood Hits	438	Target Neighborhood Hits	864	Shared Neighborhood Hits	69
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

RNF37_MOUSE
NC score	0.060022 (rank : 466)	θ value	3.0926 (rank : 347)
Query Neighborhood Hits	438	Target Neighborhood Hits	102	Shared Neighborhood Hits	58
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

MNAB_HUMAN
NC score	0.059252 (rank : 467)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	93
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

MNAB_MOUSE
NC score	0.058709 (rank : 468)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	438	Target Neighborhood Hits	231	Shared Neighborhood Hits	95
SwissProt Accessions	P0C090	Gene names	Mnab
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein.

RNF38_HUMAN
NC score	0.058508 (rank : 469)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	438	Target Neighborhood Hits	155	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0F5, Q8N0Y0	Gene names	RNF38
Domain Architecture	No domain graphic available
Description	RING finger protein 38.

RKHD1_HUMAN
NC score	0.058156 (rank : 470)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	67
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF38_MOUSE
NC score	0.057361 (rank : 471)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	438	Target Neighborhood Hits	153	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BI21, Q6P5B1	Gene names	Rnf38
Domain Architecture	No domain graphic available
Description	RING finger protein 38.

RNF12_MOUSE
NC score	0.056495 (rank : 472)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	438	Target Neighborhood Hits	159	Shared Neighborhood Hits	68
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

TIF1B_HUMAN
NC score	0.056116 (rank : 473)	θ value	8.99809 (rank : 431)
Query Neighborhood Hits	438	Target Neighborhood Hits	312	Shared Neighborhood Hits	99
SwissProt Accessions	Q13263, O00677, Q7Z632, Q93040, Q96IM1	Gene names	TRIM28, KAP1, RNF96, TIF1B
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (Nuclear corepressor KAP-1) (KRAB- associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (RING finger protein 96).

BICD1_MOUSE
NC score	0.055942 (rank : 474)	θ value	0.0252991 (rank : 162)
Query Neighborhood Hits	438	Target Neighborhood Hits	837	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

XE7_HUMAN
NC score	0.055420 (rank : 475)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	438	Target Neighborhood Hits	738	Shared Neighborhood Hits	59
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

BICD1_HUMAN
NC score	0.055096 (rank : 476)	θ value	0.0113563 (rank : 154)
Query Neighborhood Hits	438	Target Neighborhood Hits	844	Shared Neighborhood Hits	61
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

TIF1B_MOUSE
NC score	0.054112 (rank : 477)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	438	Target Neighborhood Hits	276	Shared Neighborhood Hits	97
SwissProt Accessions	Q62318, P70391, Q8C283, Q99PN4	Gene names	Trim28, Krip1, Tif1b
Domain Architecture
Description	Transcription intermediary factor 1-beta (TIF1-beta) (Tripartite motif-containing protein 28) (KRAB-A-interacting protein) (KRIP-1).

CENPB_MOUSE
NC score	0.053060 (rank : 478)	θ value	0.125558 (rank : 222)
Query Neighborhood Hits	438	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

CAR14_MOUSE
NC score	0.052559 (rank : 479)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	438	Target Neighborhood Hits	526	Shared Neighborhood Hits	64
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

RNF6_HUMAN
NC score	0.051995 (rank : 480)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	438	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

BRAP_HUMAN
NC score	0.050978 (rank : 481)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	438	Target Neighborhood Hits	560	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

WWC1_HUMAN
NC score	0.050949 (rank : 482)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	438	Target Neighborhood Hits	290	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

RNF12_HUMAN
NC score	0.050898 (rank : 483)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	438	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NVW2, Q9Y598	Gene names	RNF12, RLIM
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (NY-REN-43 antigen).

RNF37_HUMAN
NC score	0.050836 (rank : 484)	θ value	2.36792 (rank : 329)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	O94941	Gene names	UBOX5, KIAA0860, RNF37, UBCE7IP5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (U-box domain-containing protein 5).

BRAP_MOUSE
NC score	0.050648 (rank : 485)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	438	Target Neighborhood Hits	409	Shared Neighborhood Hits	97
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

CENPB_HUMAN
NC score	0.048775 (rank : 486)	θ value	0.163984 (rank : 235)
Query Neighborhood Hits	438	Target Neighborhood Hits	133	Shared Neighborhood Hits	13
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

PEX2_MOUSE
NC score	0.045977 (rank : 487)	θ value	8.99809 (rank : 418)
Query Neighborhood Hits	438	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	P55098, O35467	Gene names	Pxmp3, Paf1, Pex2, Pmp35
Domain Architecture
Description	Peroxisome assembly factor 1 (PAF-1) (Peroxin-2) (Peroxisomal membrane protein 3).

ARD1_MOUSE
NC score	0.044780 (rank : 488)	θ value	1.06291 (rank : 296)
Query Neighborhood Hits	438	Target Neighborhood Hits	573	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

DSPP_HUMAN
NC score	0.044301 (rank : 489)	θ value	0.47712 (rank : 275)
Query Neighborhood Hits	438	Target Neighborhood Hits	645	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

ARD1_HUMAN
NC score	0.041556 (rank : 490)	θ value	1.06291 (rank : 295)
Query Neighborhood Hits	438	Target Neighborhood Hits	621	Shared Neighborhood Hits	69
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

GOGB1_HUMAN
NC score	0.040923 (rank : 491)	θ value	0.0330416 (rank : 167)
Query Neighborhood Hits	438	Target Neighborhood Hits	2297	Shared Neighborhood Hits	145
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

NIN_HUMAN
NC score	0.039505 (rank : 492)	θ value	0.00869519 (rank : 148)
Query Neighborhood Hits	438	Target Neighborhood Hits	1416	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NEST_HUMAN
NC score	0.035004 (rank : 493)	θ value	0.0736092 (rank : 198)
Query Neighborhood Hits	438	Target Neighborhood Hits	1305	Shared Neighborhood Hits	82
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

CENPF_HUMAN
NC score	0.034358 (rank : 494)	θ value	4.03905 (rank : 349)
Query Neighborhood Hits	438	Target Neighborhood Hits	1932	Shared Neighborhood Hits	119
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

KNTC2_HUMAN
NC score	0.034093 (rank : 495)	θ value	0.62314 (rank : 286)
Query Neighborhood Hits	438	Target Neighborhood Hits	673	Shared Neighborhood Hits	58
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

BIRC2_HUMAN
NC score	0.033961 (rank : 496)	θ value	6.88961 (rank : 389)
Query Neighborhood Hits	438	Target Neighborhood Hits	142	Shared Neighborhood Hits	78
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

TXLNG_HUMAN
NC score	0.033936 (rank : 497)	θ value	0.365318 (rank : 270)
Query Neighborhood Hits	438	Target Neighborhood Hits	568	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

CF060_HUMAN
NC score	0.033872 (rank : 498)	θ value	0.62314 (rank : 280)
Query Neighborhood Hits	438	Target Neighborhood Hits	1270	Shared Neighborhood Hits	97
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

GOGA5_MOUSE
NC score	0.033831 (rank : 499)	θ value	0.00228821 (rank : 135)
Query Neighborhood Hits	438	Target Neighborhood Hits	1434	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

AKAP9_HUMAN
NC score	0.033283 (rank : 500)	θ value	3.0926 (rank : 335)
Query Neighborhood Hits	438	Target Neighborhood Hits	1710	Shared Neighborhood Hits	99
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

MACOI_MOUSE
NC score	0.032528 (rank : 501)	θ value	5.27518 (rank : 373)
Query Neighborhood Hits	438	Target Neighborhood Hits	620	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

TXLNG_MOUSE
NC score	0.032176 (rank : 502)	θ value	8.99809 (rank : 435)
Query Neighborhood Hits	438	Target Neighborhood Hits	552	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

CI039_HUMAN
NC score	0.031590 (rank : 503)	θ value	0.279714 (rank : 253)
Query Neighborhood Hits	438	Target Neighborhood Hits	1171	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

GORS2_HUMAN
NC score	0.031253 (rank : 504)	θ value	0.62314 (rank : 284)
Query Neighborhood Hits	438	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8Y8, Q96I74, Q96K84, Q9H946, Q9UFW4	Gene names	GORASP2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59) (Golgi phosphoprotein 6) (GOLPH6).

GOGA5_HUMAN
NC score	0.030782 (rank : 505)	θ value	6.88961 (rank : 396)
Query Neighborhood Hits	438	Target Neighborhood Hits	1168	Shared Neighborhood Hits	75
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

EEA1_HUMAN
NC score	0.030495 (rank : 506)	θ value	6.88961 (rank : 395)
Query Neighborhood Hits	438	Target Neighborhood Hits	1796	Shared Neighborhood Hits	116
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

RB6I2_HUMAN
NC score	0.030157 (rank : 507)	θ value	5.27518 (rank : 375)
Query Neighborhood Hits	438	Target Neighborhood Hits	1584	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
NC score	0.029666 (rank : 508)	θ value	6.88961 (rank : 403)
Query Neighborhood Hits	438	Target Neighborhood Hits	1433	Shared Neighborhood Hits	92
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

GORS2_MOUSE
NC score	0.029535 (rank : 509)	θ value	0.62314 (rank : 285)
Query Neighborhood Hits	438	Target Neighborhood Hits	89	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

REST_HUMAN
NC score	0.029057 (rank : 510)	θ value	4.03905 (rank : 358)
Query Neighborhood Hits	438	Target Neighborhood Hits	1605	Shared Neighborhood Hits	101
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

MACOI_HUMAN
NC score	0.028841 (rank : 511)	θ value	8.99809 (rank : 415)
Query Neighborhood Hits	438	Target Neighborhood Hits	650	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

CCD46_MOUSE
NC score	0.028585 (rank : 512)	θ value	6.88961 (rank : 390)
Query Neighborhood Hits	438	Target Neighborhood Hits	1405	Shared Neighborhood Hits	97
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

HIP1R_HUMAN
NC score	0.027984 (rank : 513)	θ value	1.81305 (rank : 315)
Query Neighborhood Hits	438	Target Neighborhood Hits	809	Shared Neighborhood Hits	58
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

CING_HUMAN
NC score	0.026443 (rank : 514)	θ value	6.88961 (rank : 392)
Query Neighborhood Hits	438	Target Neighborhood Hits	1275	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

MIB1_MOUSE
NC score	0.026188 (rank : 515)	θ value	8.99809 (rank : 416)
Query Neighborhood Hits	438	Target Neighborhood Hits	471	Shared Neighborhood Hits	83
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MAST1_MOUSE
NC score	0.025549 (rank : 516)	θ value	2.36792 (rank : 323)
Query Neighborhood Hits	438	Target Neighborhood Hits	1123	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SCF_MOUSE
NC score	0.024691 (rank : 517)	θ value	2.36792 (rank : 331)
Query Neighborhood Hits	438	Target Neighborhood Hits	3	Shared Neighborhood Hits	3
SwissProt Accessions	P20826, P97332, Q3TNJ7, Q62524, Q64222, Q921N5	Gene names	Kitlg, Kitl, Mgf, Sl, Slf
Domain Architecture
Description	Kit ligand precursor (C-kit ligand) (Stem cell factor) (SCF) (Mast cell growth factor) (MGF) (Hematopoietic growth factor KL) (Steel factor).

SCF_HUMAN
NC score	0.024648 (rank : 518)	θ value	2.36792 (rank : 330)
Query Neighborhood Hits	438	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P21583, Q16487, Q9UQK7	Gene names	KITLG, MGF, SCF
Domain Architecture
Description	Kit ligand precursor (C-kit ligand) (Stem cell factor) (SCF) (Mast cell growth factor) (MGF).

RUFY1_HUMAN
NC score	0.024471 (rank : 519)	θ value	5.27518 (rank : 380)
Query Neighborhood Hits	438	Target Neighborhood Hits	848	Shared Neighborhood Hits	69
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SEPT7_MOUSE
NC score	0.024292 (rank : 520)	θ value	0.21417 (rank : 249)
Query Neighborhood Hits	438	Target Neighborhood Hits	327	Shared Neighborhood Hits	36
SwissProt Accessions	O55131	Gene names	Sept7, Cdc10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

CING_MOUSE
NC score	0.023997 (rank : 521)	θ value	8.99809 (rank : 412)
Query Neighborhood Hits	438	Target Neighborhood Hits	1432	Shared Neighborhood Hits	92
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

MAST1_HUMAN
NC score	0.023991 (rank : 522)	θ value	3.0926 (rank : 341)
Query Neighborhood Hits	438	Target Neighborhood Hits	1146	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SEPT7_HUMAN
NC score	0.023726 (rank : 523)	θ value	0.21417 (rank : 248)
Query Neighborhood Hits	438	Target Neighborhood Hits	385	Shared Neighborhood Hits	41
SwissProt Accessions	Q16181, Q6NX50	Gene names	SEPT7, CDC10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

HOME2_MOUSE
NC score	0.022431 (rank : 524)	θ value	6.88961 (rank : 398)
Query Neighborhood Hits	438	Target Neighborhood Hits	882	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

LEO1_MOUSE
NC score	0.019816 (rank : 525)	θ value	0.365318 (rank : 264)
Query Neighborhood Hits	438	Target Neighborhood Hits	946	Shared Neighborhood Hits	44
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

CJ078_MOUSE
NC score	0.019575 (rank : 526)	θ value	3.0926 (rank : 337)
Query Neighborhood Hits	438	Target Neighborhood Hits	559	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

MYH9_HUMAN
NC score	0.018736 (rank : 527)	θ value	8.99809 (rank : 417)
Query Neighborhood Hits	438	Target Neighborhood Hits	1762	Shared Neighborhood Hits	112
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PPIP2_HUMAN
NC score	0.018489 (rank : 528)	θ value	3.0926 (rank : 343)
Query Neighborhood Hits	438	Target Neighborhood Hits	254	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

LEO1_HUMAN
NC score	0.017305 (rank : 529)	θ value	8.99809 (rank : 414)
Query Neighborhood Hits	438	Target Neighborhood Hits	958	Shared Neighborhood Hits	46
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

HGS_MOUSE
NC score	0.015831 (rank : 530)	θ value	1.81305 (rank : 314)
Query Neighborhood Hits	438	Target Neighborhood Hits	589	Shared Neighborhood Hits	31
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

NSBP1_MOUSE
NC score	0.015515 (rank : 531)	θ value	4.03905 (rank : 356)
Query Neighborhood Hits	438	Target Neighborhood Hits	681	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

K1914_HUMAN
NC score	0.015107 (rank : 532)	θ value	6.88961 (rank : 399)
Query Neighborhood Hits	438	Target Neighborhood Hits	255	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4X5, Q8TB54, Q96PX4, Q96SY5	Gene names	KIAA1914
Domain Architecture	No domain graphic available
Description	Protein KIAA1914.

CF122_HUMAN
NC score	0.014514 (rank : 533)	θ value	6.88961 (rank : 391)
Query Neighborhood Hits	438	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T6M2, Q96N37	Gene names	C6orf122
Domain Architecture	No domain graphic available
Description	Protein C6orf122.

MLL2_HUMAN
NC score	0.014333 (rank : 534)	θ value	6.88961 (rank : 400)
Query Neighborhood Hits	438	Target Neighborhood Hits	1788	Shared Neighborhood Hits	87
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NPAS3_MOUSE
NC score	0.013794 (rank : 535)	θ value	4.03905 (rank : 355)
Query Neighborhood Hits	438	Target Neighborhood Hits	103	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

HGS_HUMAN
NC score	0.013443 (rank : 536)	θ value	4.03905 (rank : 351)
Query Neighborhood Hits	438	Target Neighborhood Hits	517	Shared Neighborhood Hits	30
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZN638_MOUSE
NC score	0.012803 (rank : 537)	θ value	2.36792 (rank : 334)
Query Neighborhood Hits	438	Target Neighborhood Hits	318	Shared Neighborhood Hits	18
SwissProt Accessions	Q61464, Q6DFV9, Q8C941	Gene names	Znf638, Np220, Zfml
Domain Architecture	No domain graphic available
Description	Zinc finger protein 638 (Nuclear protein 220) (Zinc-finger matrin-like protein).

NPAS3_HUMAN
NC score	0.012703 (rank : 538)	θ value	0.813845 (rank : 293)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NALP4_HUMAN
NC score	0.011752 (rank : 539)	θ value	4.03905 (rank : 353)
Query Neighborhood Hits	438	Target Neighborhood Hits	81	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

SPTB1_MOUSE
NC score	0.011077 (rank : 540)	θ value	3.0926 (rank : 348)
Query Neighborhood Hits	438	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

C8AP2_HUMAN
NC score	0.010935 (rank : 541)	θ value	8.99809 (rank : 410)
Query Neighborhood Hits	438	Target Neighborhood Hits	548	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

TTL12_HUMAN
NC score	0.010926 (rank : 542)	θ value	6.88961 (rank : 409)
Query Neighborhood Hits	438	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q14166, Q9UGU3	Gene names	TTLL12, KIAA0153
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 12.

GON4L_HUMAN
NC score	0.009826 (rank : 543)	θ value	5.27518 (rank : 371)
Query Neighborhood Hits	438	Target Neighborhood Hits	555	Shared Neighborhood Hits	29
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

ESCO2_HUMAN
NC score	0.009631 (rank : 544)	θ value	4.03905 (rank : 350)
Query Neighborhood Hits	438	Target Neighborhood Hits	45	Shared Neighborhood Hits	3
SwissProt Accessions	Q56NI9	Gene names	ESCO2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

HN1L_MOUSE
NC score	0.008750 (rank : 545)	θ value	6.88961 (rank : 397)
Query Neighborhood Hits	438	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PGH2	Gene names	D17Ertd441e
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

RPGR_HUMAN
NC score	0.008049 (rank : 546)	θ value	5.27518 (rank : 379)
Query Neighborhood Hits	438	Target Neighborhood Hits	279	Shared Neighborhood Hits	20
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

MRCKB_MOUSE
NC score	0.008016 (rank : 547)	θ value	3.0926 (rank : 342)
Query Neighborhood Hits	438	Target Neighborhood Hits	2180	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

CA082_MOUSE
NC score	0.007364 (rank : 548)	θ value	8.99809 (rank : 411)
Query Neighborhood Hits	438	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC34, Q3TLC8, Q3TSP8, Q3UKX0, Q8C7M5, Q8CBW8	Gene names
Domain Architecture	No domain graphic available
Description	UPF0385 protein C1orf82 homolog.

NALP5_MOUSE
NC score	0.007171 (rank : 549)	θ value	5.27518 (rank : 374)
Query Neighborhood Hits	438	Target Neighborhood Hits	560	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

UB7I4_MOUSE
NC score	0.006491 (rank : 550)	θ value	8.99809 (rank : 436)
Query Neighborhood Hits	438	Target Neighborhood Hits	59	Shared Neighborhood Hits	12
SwissProt Accessions	Q925F3, Q6A0B4	Gene names	Rnf144, Kiaa0161, Ubce7ip4, Uip4
Domain Architecture
Description	Ubiquitin-conjugating enzyme 7-interacting protein 4 (UbcM4- interacting protein 4) (RING finger protein 144).

AIRE_MOUSE
NC score	0.006294 (rank : 551)	θ value	5.27518 (rank : 366)
Query Neighborhood Hits	438	Target Neighborhood Hits	196	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

MRCKB_HUMAN
NC score	0.006001 (rank : 552)	θ value	1.81305 (rank : 317)
Query Neighborhood Hits	438	Target Neighborhood Hits	2239	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

SPG16_HUMAN
NC score	0.005661 (rank : 553)	θ value	5.27518 (rank : 382)
Query Neighborhood Hits	438	Target Neighborhood Hits	361	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N0X2, Q658W1, Q68DB3, Q6I9Z6, Q8N9C7, Q9H601	Gene names	SPAG16, PF20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

I18RA_HUMAN
NC score	0.004627 (rank : 554)	θ value	4.03905 (rank : 352)
Query Neighborhood Hits	438	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

DIDO1_HUMAN
NC score	0.004239 (rank : 555)	θ value	5.27518 (rank : 368)
Query Neighborhood Hits	438	Target Neighborhood Hits	960	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

SETB1_HUMAN
NC score	0.004150 (rank : 556)	θ value	8.99809 (rank : 430)
Query Neighborhood Hits	438	Target Neighborhood Hits	141	Shared Neighborhood Hits	9
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SMCA1_HUMAN
NC score	0.003798 (rank : 557)	θ value	4.03905 (rank : 361)
Query Neighborhood Hits	438	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	P28370, Q5JV41, Q5JV42	Gene names	SMARCA1, SNF2L, SNF2L1
Domain Architecture
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1).

HDAC6_MOUSE
NC score	0.003178 (rank : 558)	θ value	5.27518 (rank : 372)
Query Neighborhood Hits	438	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2V5	Gene names	Hdac6
Domain Architecture
Description	Histone deacetylase 6 (HD6) (Histone deacetylase mHDA2).

ANKY2_MOUSE
NC score	0.002670 (rank : 559)	θ value	3.0926 (rank : 336)
Query Neighborhood Hits	438	Target Neighborhood Hits	316	Shared Neighborhood Hits	6
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

STK10_MOUSE
NC score	0.000395 (rank : 560)	θ value	2.36792 (rank : 332)
Query Neighborhood Hits	438	Target Neighborhood Hits	2132	Shared Neighborhood Hits	92
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ANR25_HUMAN
NC score	0.000104 (rank : 561)	θ value	6.88961 (rank : 387)
Query Neighborhood Hits	438	Target Neighborhood Hits	350	Shared Neighborhood Hits	8
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

SDK2_MOUSE
NC score	-0.003634 (rank : 562)	θ value	4.03905 (rank : 360)
Query Neighborhood Hits	438	Target Neighborhood Hits	480	Shared Neighborhood Hits	11
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SPEG_MOUSE
NC score	-0.004145 (rank : 563)	θ value	4.03905 (rank : 362)
Query Neighborhood Hits	438	Target Neighborhood Hits	1959	Shared Neighborhood Hits	40
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CD2L2_HUMAN
NC score	-0.004530 (rank : 564)	θ value	5.27518 (rank : 367)
Query Neighborhood Hits	438	Target Neighborhood Hits	1439	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

SUHW4_HUMAN
NC score	-0.005272 (rank : 565)	θ value	4.03905 (rank : 363)
Query Neighborhood Hits	438	Target Neighborhood Hits	860	Shared Neighborhood Hits	22
SwissProt Accessions	Q6N043, Q6MZM6, Q6N085, Q9H0U5, Q9HCI8, Q9NXS0	Gene names	SUHW4, KIAA1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 4.

PLK2_HUMAN
NC score	-0.006946 (rank : 566)	θ value	6.88961 (rank : 401)
Query Neighborhood Hits	438	Target Neighborhood Hits	854	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

KPCZ_HUMAN
NC score	-0.007338 (rank : 567)	θ value	3.0926 (rank : 340)
Query Neighborhood Hits	438	Target Neighborhood Hits	884	Shared Neighborhood Hits	14
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

SPEG_HUMAN
NC score	-0.007615 (rank : 568)	θ value	5.27518 (rank : 381)
Query Neighborhood Hits	438	Target Neighborhood Hits	1762	Shared Neighborhood Hits	29
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

FES_HUMAN
NC score	-0.009588 (rank : 569)	θ value	8.99809 (rank : 413)
Query Neighborhood Hits	438	Target Neighborhood Hits	978	Shared Neighborhood Hits	24
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).