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Network neighborhood for query Sequence : SIAH2_HUMAN

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SIAH2_HUMAN
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIAH2_HUMAN
θ value	3.26429e-159 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	94
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	5.21151e-157 (rank : 2)	NC score	0.995915 (rank : 2)
Query Neighborhood Hits	94	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

SIA1A_MOUSE
θ value	8.37844e-131 (rank : 3)	NC score	0.975414 (rank : 4)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIAH1_HUMAN
θ value	1.86652e-130 (rank : 4)	NC score	0.975877 (rank : 3)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SIA1B_MOUSE
θ value	2.69525e-129 (rank : 5)	NC score	0.975194 (rank : 5)
Query Neighborhood Hits	94	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

TRAF7_MOUSE
θ value	7.59969e-07 (rank : 6)	NC score	0.188928 (rank : 13)
Query Neighborhood Hits	94	Target Neighborhood Hits	470	Shared Neighborhood Hits	53
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRAF7_HUMAN
θ value	2.21117e-06 (rank : 7)	NC score	0.182048 (rank : 15)
Query Neighborhood Hits	94	Target Neighborhood Hits	482	Shared Neighborhood Hits	53
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRI50_HUMAN
θ value	2.88788e-06 (rank : 8)	NC score	0.158340 (rank : 26)
Query Neighborhood Hits	94	Target Neighborhood Hits	294	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI50_MOUSE
θ value	6.43352e-06 (rank : 9)	NC score	0.155953 (rank : 28)
Query Neighborhood Hits	94	Target Neighborhood Hits	326	Shared Neighborhood Hits	72
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

PZRN3_HUMAN
θ value	1.43324e-05 (rank : 10)	NC score	0.185622 (rank : 14)
Query Neighborhood Hits	94	Target Neighborhood Hits	461	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

ZN313_MOUSE
θ value	1.43324e-05 (rank : 11)	NC score	0.313077 (rank : 6)
Query Neighborhood Hits	94	Target Neighborhood Hits	273	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

ZN313_HUMAN
θ value	0.000158464 (rank : 12)	NC score	0.282461 (rank : 7)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

PZRN3_MOUSE
θ value	0.000270298 (rank : 13)	NC score	0.174702 (rank : 16)
Query Neighborhood Hits	94	Target Neighborhood Hits	447	Shared Neighborhood Hits	47
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RN166_MOUSE
θ value	0.00175202 (rank : 14)	NC score	0.249828 (rank : 9)
Query Neighborhood Hits	94	Target Neighborhood Hits	248	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

BIRC7_HUMAN
θ value	0.00390308 (rank : 15)	NC score	0.252075 (rank : 8)
Query Neighborhood Hits	94	Target Neighborhood Hits	185	Shared Neighborhood Hits	54
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

MIB2_HUMAN
θ value	0.00509761 (rank : 16)	NC score	0.119223 (rank : 44)
Query Neighborhood Hits	94	Target Neighborhood Hits	438	Shared Neighborhood Hits	47
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

RN166_HUMAN
θ value	0.00665767 (rank : 17)	NC score	0.235755 (rank : 10)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	53
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

MIB2_MOUSE
θ value	0.0148317 (rank : 18)	NC score	0.116483 (rank : 46)
Query Neighborhood Hits	94	Target Neighborhood Hits	409	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

MIB1_HUMAN
θ value	0.0252991 (rank : 19)	NC score	0.093354 (rank : 58)
Query Neighborhood Hits	94	Target Neighborhood Hits	470	Shared Neighborhood Hits	45
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0.0252991 (rank : 20)	NC score	0.093324 (rank : 59)
Query Neighborhood Hits	94	Target Neighborhood Hits	471	Shared Neighborhood Hits	45
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

BRCA1_MOUSE
θ value	0.0330416 (rank : 21)	NC score	0.153353 (rank : 30)
Query Neighborhood Hits	94	Target Neighborhood Hits	436	Shared Neighborhood Hits	60
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

MUC1_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.026444 (rank : 194)
Query Neighborhood Hits	94	Target Neighborhood Hits	975	Shared Neighborhood Hits	12
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

BIRC3_MOUSE
θ value	0.0431538 (rank : 23)	NC score	0.163293 (rank : 22)
Query Neighborhood Hits	94	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

RNF41_HUMAN
θ value	0.0431538 (rank : 24)	NC score	0.168438 (rank : 21)
Query Neighborhood Hits	94	Target Neighborhood Hits	226	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	0.0431538 (rank : 25)	NC score	0.168510 (rank : 20)
Query Neighborhood Hits	94	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

BIRC2_MOUSE
θ value	0.0961366 (rank : 26)	NC score	0.157645 (rank : 27)
Query Neighborhood Hits	94	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

RN152_HUMAN
θ value	0.0961366 (rank : 27)	NC score	0.189557 (rank : 12)
Query Neighborhood Hits	94	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

RN152_MOUSE
θ value	0.0961366 (rank : 28)	NC score	0.190011 (rank : 11)
Query Neighborhood Hits	94	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

TRI32_HUMAN
θ value	0.125558 (rank : 29)	NC score	0.115045 (rank : 49)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	45
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	0.125558 (rank : 30)	NC score	0.115494 (rank : 48)
Query Neighborhood Hits	94	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

BIRC2_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.152243 (rank : 31)
Query Neighborhood Hits	94	Target Neighborhood Hits	142	Shared Neighborhood Hits	43
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

PZRN4_HUMAN
θ value	0.163984 (rank : 32)	NC score	0.159317 (rank : 24)
Query Neighborhood Hits	94	Target Neighborhood Hits	438	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RNF34_HUMAN
θ value	0.163984 (rank : 33)	NC score	0.172968 (rank : 17)
Query Neighborhood Hits	94	Target Neighborhood Hits	153	Shared Neighborhood Hits	40
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	0.163984 (rank : 34)	NC score	0.172927 (rank : 18)
Query Neighborhood Hits	94	Target Neighborhood Hits	160	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

I17RA_HUMAN
θ value	0.21417 (rank : 35)	NC score	0.037065 (rank : 191)
Query Neighborhood Hits	94	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q96F46, O43844	Gene names	IL17RA, IL17R
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor A precursor (IL-17 receptor).

TRAF6_HUMAN
θ value	0.21417 (rank : 36)	NC score	0.158712 (rank : 25)
Query Neighborhood Hits	94	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

TRIM3_HUMAN
θ value	0.21417 (rank : 37)	NC score	0.079800 (rank : 77)
Query Neighborhood Hits	94	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

ARD1_MOUSE
θ value	0.279714 (rank : 38)	NC score	0.039800 (rank : 189)
Query Neighborhood Hits	94	Target Neighborhood Hits	573	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

BRCA1_HUMAN
θ value	0.279714 (rank : 39)	NC score	0.154649 (rank : 29)
Query Neighborhood Hits	94	Target Neighborhood Hits	381	Shared Neighborhood Hits	58
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

RO52_HUMAN
θ value	0.279714 (rank : 40)	NC score	0.088777 (rank : 65)
Query Neighborhood Hits	94	Target Neighborhood Hits	419	Shared Neighborhood Hits	71
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRAF5_MOUSE
θ value	0.279714 (rank : 41)	NC score	0.127003 (rank : 41)
Query Neighborhood Hits	94	Target Neighborhood Hits	355	Shared Neighborhood Hits	39
SwissProt Accessions	P70191, Q61480	Gene names	Traf5
Domain Architecture
Description	TNF receptor-associated factor 5.

TRAF6_MOUSE
θ value	0.279714 (rank : 42)	NC score	0.160060 (rank : 23)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	46
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

TRAF1_HUMAN
θ value	0.365318 (rank : 43)	NC score	0.060308 (rank : 151)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	Q13077, Q8NF13	Gene names	TRAF1, EBI6
Domain Architecture
Description	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6).

CIC_MOUSE
θ value	0.62314 (rank : 44)	NC score	0.040571 (rank : 188)
Query Neighborhood Hits	94	Target Neighborhood Hits	742	Shared Neighborhood Hits	15
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NEUL1_HUMAN
θ value	0.62314 (rank : 45)	NC score	0.133242 (rank : 35)
Query Neighborhood Hits	94	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

BIRC3_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.145535 (rank : 32)
Query Neighborhood Hits	94	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

CIC_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.034183 (rank : 192)
Query Neighborhood Hits	94	Target Neighborhood Hits	992	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

UB7I1_MOUSE
θ value	1.06291 (rank : 48)	NC score	0.059797 (rank : 157)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	8
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

BIRC8_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.117768 (rank : 45)
Query Neighborhood Hits	94	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

ERBB2_HUMAN
θ value	1.38821 (rank : 50)	NC score	0.000483 (rank : 205)
Query Neighborhood Hits	94	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

RFFL_HUMAN
θ value	1.38821 (rank : 51)	NC score	0.135994 (rank : 34)
Query Neighborhood Hits	94	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	1.38821 (rank : 52)	NC score	0.137113 (rank : 33)
Query Neighborhood Hits	94	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

BAT2_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.045902 (rank : 187)
Query Neighborhood Hits	94	Target Neighborhood Hits	931	Shared Neighborhood Hits	14
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CM007_MOUSE
θ value	1.81305 (rank : 54)	NC score	0.069729 (rank : 111)
Query Neighborhood Hits	94	Target Neighborhood Hits	416	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

DNER_HUMAN
θ value	1.81305 (rank : 55)	NC score	0.004742 (rank : 204)
Query Neighborhood Hits	94	Target Neighborhood Hits	460	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

LRSM1_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.046885 (rank : 186)
Query Neighborhood Hits	94	Target Neighborhood Hits	1078	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRSM1_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.053606 (rank : 178)
Query Neighborhood Hits	94	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

OGFR_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.017536 (rank : 195)
Query Neighborhood Hits	94	Target Neighborhood Hits	1582	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RFPL2_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.078765 (rank : 79)
Query Neighborhood Hits	94	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

UB7I1_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.061990 (rank : 146)
Query Neighborhood Hits	94	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

CM007_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.060168 (rank : 154)
Query Neighborhood Hits	94	Target Neighborhood Hits	422	Shared Neighborhood Hits	27
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

RC3H1_HUMAN
θ value	2.36792 (rank : 62)	NC score	0.068867 (rank : 115)
Query Neighborhood Hits	94	Target Neighborhood Hits	433	Shared Neighborhood Hits	43
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RC3H1_MOUSE
θ value	2.36792 (rank : 63)	NC score	0.071628 (rank : 104)
Query Neighborhood Hits	94	Target Neighborhood Hits	244	Shared Neighborhood Hits	42
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

TRI12_MOUSE
θ value	2.36792 (rank : 64)	NC score	0.089995 (rank : 63)
Query Neighborhood Hits	94	Target Neighborhood Hits	387	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRIM4_HUMAN
θ value	2.36792 (rank : 65)	NC score	0.098391 (rank : 53)
Query Neighborhood Hits	94	Target Neighborhood Hits	321	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

BAT2_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.037129 (rank : 190)
Query Neighborhood Hits	94	Target Neighborhood Hits	947	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CRCM1_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.014276 (rank : 197)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q96D31, Q3MHV3, Q6DHX2, Q96BP7, Q96K71	Gene names	TMEM142A, CRACM1, ORAI1
Domain Architecture	No domain graphic available
Description	Calcium release-activated calcium channel protein 1 (Transmembrane protein 142A) (Protein orai-1).

NEURL_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.131083 (rank : 37)
Query Neighborhood Hits	94	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

RGS3_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.010652 (rank : 198)
Query Neighborhood Hits	94	Target Neighborhood Hits	1375	Shared Neighborhood Hits	14
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RNF4_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.128638 (rank : 39)
Query Neighborhood Hits	94	Target Neighborhood Hits	212	Shared Neighborhood Hits	48
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.127009 (rank : 40)
Query Neighborhood Hits	94	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

TRI11_HUMAN
θ value	3.0926 (rank : 72)	NC score	0.074978 (rank : 95)
Query Neighborhood Hits	94	Target Neighborhood Hits	316	Shared Neighborhood Hits	62
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

ARD1_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.030540 (rank : 193)
Query Neighborhood Hits	94	Target Neighborhood Hits	621	Shared Neighborhood Hits	21
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

BIRC4_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.095758 (rank : 55)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	4.03905 (rank : 75)	NC score	0.095311 (rank : 56)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

TRI18_HUMAN
θ value	4.03905 (rank : 76)	NC score	0.067074 (rank : 123)
Query Neighborhood Hits	94	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI18_MOUSE
θ value	4.03905 (rank : 77)	NC score	0.067960 (rank : 116)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

GATA6_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.008813 (rank : 199)
Query Neighborhood Hits	94	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

RING1_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.121417 (rank : 42)
Query Neighborhood Hits	94	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.119640 (rank : 43)
Query Neighborhood Hits	94	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

TRAF2_MOUSE
θ value	5.27518 (rank : 81)	NC score	0.076994 (rank : 85)
Query Neighborhood Hits	94	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

TRI11_MOUSE
θ value	5.27518 (rank : 82)	NC score	0.074807 (rank : 97)
Query Neighborhood Hits	94	Target Neighborhood Hits	329	Shared Neighborhood Hits	62
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI26_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.105691 (rank : 50)
Query Neighborhood Hits	94	Target Neighborhood Hits	339	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI27_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.071135 (rank : 106)
Query Neighborhood Hits	94	Target Neighborhood Hits	261	Shared Neighborhood Hits	62
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

BAT3_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.017035 (rank : 196)
Query Neighborhood Hits	94	Target Neighborhood Hits	490	Shared Neighborhood Hits	11
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAZ2A_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.005018 (rank : 203)
Query Neighborhood Hits	94	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CO2A1_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.005128 (rank : 202)
Query Neighborhood Hits	94	Target Neighborhood Hits	486	Shared Neighborhood Hits	12
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO2A1_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.005160 (rank : 201)
Query Neighborhood Hits	94	Target Neighborhood Hits	483	Shared Neighborhood Hits	12
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

LPP_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.006201 (rank : 200)
Query Neighborhood Hits	94	Target Neighborhood Hits	775	Shared Neighborhood Hits	9
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MYLIP_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.061271 (rank : 148)
Query Neighborhood Hits	94	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

TRAF3_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.092514 (rank : 60)
Query Neighborhood Hits	94	Target Neighborhood Hits	463	Shared Neighborhood Hits	38
SwissProt Accessions	Q13114, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1	Gene names	TRAF3, CAP1, CRAF1
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein) (LAP1) (CAP-1).

TRI60_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.072383 (rank : 101)
Query Neighborhood Hits	94	Target Neighborhood Hits	357	Shared Neighborhood Hits	65
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

TRIM1_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.064658 (rank : 136)
Query Neighborhood Hits	94	Target Neighborhood Hits	345	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRIM1_MOUSE
θ value	8.99809 (rank : 94)	NC score	0.063777 (rank : 143)
Query Neighborhood Hits	94	Target Neighborhood Hits	361	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

BFAR_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.059194 (rank : 160)
Query Neighborhood Hits	94	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.057496 (rank : 164)
Query Neighborhood Hits	94	Target Neighborhood Hits	232	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CHFR_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.056285 (rank : 167)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	42
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CHFR_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.053779 (rank : 176)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	44
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

LNX1_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.054416 (rank : 174)
Query Neighborhood Hits	94	Target Neighborhood Hits	379	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX1_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.056145 (rank : 168)
Query Neighborhood Hits	94	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

LNX2_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.051946 (rank : 181)
Query Neighborhood Hits	94	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

LNX2_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.052954 (rank : 179)
Query Neighborhood Hits	94	Target Neighborhood Hits	407	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MGRN1_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.050282 (rank : 184)
Query Neighborhood Hits	94	Target Neighborhood Hits	192	Shared Neighborhood Hits	37
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

NHLC1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.053715 (rank : 177)
Query Neighborhood Hits	94	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

NHLC1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.054849 (rank : 172)
Query Neighborhood Hits	94	Target Neighborhood Hits	103	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

PDZK4_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.065722 (rank : 130)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PDZK4_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.065404 (rank : 133)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

PEX10_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.089733 (rank : 64)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

R113A_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.060019 (rank : 155)
Query Neighborhood Hits	94	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

R113B_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.059341 (rank : 159)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

RAD18_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.076655 (rank : 87)
Query Neighborhood Hits	94	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

RAD18_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.083899 (rank : 70)
Query Neighborhood Hits	94	Target Neighborhood Hits	230	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

RAG1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.075507 (rank : 94)
Query Neighborhood Hits	94	Target Neighborhood Hits	203	Shared Neighborhood Hits	42
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

RAG1_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.075962 (rank : 93)
Query Neighborhood Hits	94	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	P15919	Gene names	Rag1, Rag-1
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1).

RFPL1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.054613 (rank : 173)
Query Neighborhood Hits	94	Target Neighborhood Hits	119	Shared Neighborhood Hits	27
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

RFPL3_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.057831 (rank : 163)
Query Neighborhood Hits	94	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

RFWD2_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.076603 (rank : 88)
Query Neighborhood Hits	94	Target Neighborhood Hits	518	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.077125 (rank : 83)
Query Neighborhood Hits	94	Target Neighborhood Hits	535	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RING2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.091277 (rank : 61)
Query Neighborhood Hits	94	Target Neighborhood Hits	201	Shared Neighborhood Hits	39
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.091272 (rank : 62)
Query Neighborhood Hits	94	Target Neighborhood Hits	199	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

RKHD1_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.074318 (rank : 98)
Query Neighborhood Hits	94	Target Neighborhood Hits	163	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RN125_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.132475 (rank : 36)
Query Neighborhood Hits	94	Target Neighborhood Hits	230	Shared Neighborhood Hits	48
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

RN125_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.168741 (rank : 19)
Query Neighborhood Hits	94	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN168_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.085503 (rank : 69)
Query Neighborhood Hits	94	Target Neighborhood Hits	370	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN168_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.081164 (rank : 75)
Query Neighborhood Hits	94	Target Neighborhood Hits	440	Shared Neighborhood Hits	56
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN183_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.067461 (rank : 119)
Query Neighborhood Hits	94	Target Neighborhood Hits	126	Shared Neighborhood Hits	34
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RN183_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.064898 (rank : 135)
Query Neighborhood Hits	94	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RN185_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.088005 (rank : 66)
Query Neighborhood Hits	94	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.086654 (rank : 68)
Query Neighborhood Hits	94	Target Neighborhood Hits	211	Shared Neighborhood Hits	54
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF26_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.076429 (rank : 89)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RNF39_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.060219 (rank : 152)
Query Neighborhood Hits	94	Target Neighborhood Hits	200	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

RNF5_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.076015 (rank : 92)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.076042 (rank : 91)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RNF8_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.069152 (rank : 112)
Query Neighborhood Hits	94	Target Neighborhood Hits	622	Shared Neighborhood Hits	62
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

RNF8_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.072271 (rank : 102)
Query Neighborhood Hits	94	Target Neighborhood Hits	618	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

RO52_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.069787 (rank : 110)
Query Neighborhood Hits	94	Target Neighborhood Hits	360	Shared Neighborhood Hits	65
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRAF2_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.064189 (rank : 141)
Query Neighborhood Hits	94	Target Neighborhood Hits	402	Shared Neighborhood Hits	29
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

TRAF3_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.086989 (rank : 67)
Query Neighborhood Hits	94	Target Neighborhood Hits	476	Shared Neighborhood Hits	36
SwissProt Accessions	Q60803, Q62380	Gene names	Traf3, Craf1, Trafamn
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN).

TRAF4_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.129610 (rank : 38)
Query Neighborhood Hits	94	Target Neighborhood Hits	373	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BUZ4, O75615, Q14848, Q2PJN8	Gene names	TRAF4, CART1, MLN62, RNF83
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Malignant 62) (RING finger protein 83).

TRAF4_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.116277 (rank : 47)
Query Neighborhood Hits	94	Target Neighborhood Hits	338	Shared Neighborhood Hits	32
SwissProt Accessions	Q61382	Gene names	Traf4, Cart1
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1).

TRAF5_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.094419 (rank : 57)
Query Neighborhood Hits	94	Target Neighborhood Hits	396	Shared Neighborhood Hits	32
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

TRI10_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.070137 (rank : 108)
Query Neighborhood Hits	94	Target Neighborhood Hits	315	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI10_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.067304 (rank : 121)
Query Neighborhood Hits	94	Target Neighborhood Hits	285	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI13_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.076978 (rank : 86)
Query Neighborhood Hits	94	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI13_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.078328 (rank : 80)
Query Neighborhood Hits	94	Target Neighborhood Hits	282	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI15_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.060192 (rank : 153)
Query Neighborhood Hits	94	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI17_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.067187 (rank : 122)
Query Neighborhood Hits	94	Target Neighborhood Hits	318	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI17_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.061349 (rank : 147)
Query Neighborhood Hits	94	Target Neighborhood Hits	620	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI22_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.071296 (rank : 105)
Query Neighborhood Hits	94	Target Neighborhood Hits	396	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI25_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.071665 (rank : 103)
Query Neighborhood Hits	94	Target Neighborhood Hits	472	Shared Neighborhood Hits	56
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI25_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.077364 (rank : 82)
Query Neighborhood Hits	94	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI26_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.102280 (rank : 52)
Query Neighborhood Hits	94	Target Neighborhood Hits	335	Shared Neighborhood Hits	70
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI27_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.065876 (rank : 129)
Query Neighborhood Hits	94	Target Neighborhood Hits	273	Shared Neighborhood Hits	62
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI30_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.068870 (rank : 114)
Query Neighborhood Hits	94	Target Neighborhood Hits	434	Shared Neighborhood Hits	50
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI31_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.083374 (rank : 72)
Query Neighborhood Hits	94	Target Neighborhood Hits	299	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI34_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.064640 (rank : 137)
Query Neighborhood Hits	94	Target Neighborhood Hits	416	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRI34_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.056752 (rank : 165)
Query Neighborhood Hits	94	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI35_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.076338 (rank : 90)
Query Neighborhood Hits	94	Target Neighborhood Hits	382	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

TRI35_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.074892 (rank : 96)
Query Neighborhood Hits	94	Target Neighborhood Hits	465	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI38_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.064556 (rank : 140)
Query Neighborhood Hits	94	Target Neighborhood Hits	373	Shared Neighborhood Hits	56
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRI39_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.066344 (rank : 126)
Query Neighborhood Hits	94	Target Neighborhood Hits	693	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.066676 (rank : 124)
Query Neighborhood Hits	94	Target Neighborhood Hits	691	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI40_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.078029 (rank : 81)
Query Neighborhood Hits	94	Target Neighborhood Hits	279	Shared Neighborhood Hits	55
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI41_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.060378 (rank : 150)
Query Neighborhood Hits	94	Target Neighborhood Hits	349	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI43_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.065578 (rank : 131)
Query Neighborhood Hits	94	Target Neighborhood Hits	341	Shared Neighborhood Hits	58
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI46_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.050301 (rank : 183)
Query Neighborhood Hits	94	Target Neighborhood Hits	291	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.050160 (rank : 185)
Query Neighborhood Hits	94	Target Neighborhood Hits	287	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI47_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.066293 (rank : 127)
Query Neighborhood Hits	94	Target Neighborhood Hits	286	Shared Neighborhood Hits	52
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.067377 (rank : 120)
Query Neighborhood Hits	94	Target Neighborhood Hits	295	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI48_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.065046 (rank : 134)
Query Neighborhood Hits	94	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI49_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.058100 (rank : 162)
Query Neighborhood Hits	94	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI52_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.079149 (rank : 78)
Query Neighborhood Hits	94	Target Neighborhood Hits	213	Shared Neighborhood Hits	56
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI54_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.063567 (rank : 144)
Query Neighborhood Hits	94	Target Neighborhood Hits	209	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.059959 (rank : 156)
Query Neighborhood Hits	94	Target Neighborhood Hits	197	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI55_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.059593 (rank : 158)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRI56_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.058709 (rank : 161)
Query Neighborhood Hits	94	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI56_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.054037 (rank : 175)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

TRI59_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.083163 (rank : 73)
Query Neighborhood Hits	94	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI59_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.083430 (rank : 71)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	48
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI60_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.060681 (rank : 149)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRI62_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.063188 (rank : 145)
Query Neighborhood Hits	94	Target Neighborhood Hits	584	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.065566 (rank : 132)
Query Neighborhood Hits	94	Target Neighborhood Hits	478	Shared Neighborhood Hits	46
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI63_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.055665 (rank : 169)
Query Neighborhood Hits	94	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI63_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.056727 (rank : 166)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

TRI65_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.081085 (rank : 76)
Query Neighborhood Hits	94	Target Neighborhood Hits	330	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI65_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.081682 (rank : 74)
Query Neighborhood Hits	94	Target Neighborhood Hits	340	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI68_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.067591 (rank : 118)
Query Neighborhood Hits	94	Target Neighborhood Hits	267	Shared Neighborhood Hits	53
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

TRI68_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.072672 (rank : 100)
Query Neighborhood Hits	94	Target Neighborhood Hits	356	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

TRI73_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.102315 (rank : 51)
Query Neighborhood Hits	94	Target Neighborhood Hits	258	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI74_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.098292 (rank : 54)
Query Neighborhood Hits	94	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRIM2_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.064630 (rank : 138)
Query Neighborhood Hits	94	Target Neighborhood Hits	330	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM2_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.064097 (rank : 142)
Query Neighborhood Hits	94	Target Neighborhood Hits	331	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRIM3_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.064597 (rank : 139)
Query Neighborhood Hits	94	Target Neighborhood Hits	351	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRIM5_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.072776 (rank : 99)
Query Neighborhood Hits	94	Target Neighborhood Hits	424	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRIM6_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.068981 (rank : 113)
Query Neighborhood Hits	94	Target Neighborhood Hits	412	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

TRIM6_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.067750 (rank : 117)
Query Neighborhood Hits	94	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRIM7_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.065952 (rank : 128)
Query Neighborhood Hits	94	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRIM7_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.066468 (rank : 125)
Query Neighborhood Hits	94	Target Neighborhood Hits	358	Shared Neighborhood Hits	47
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRIM8_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.070583 (rank : 107)
Query Neighborhood Hits	94	Target Neighborhood Hits	650	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.070044 (rank : 109)
Query Neighborhood Hits	94	Target Neighborhood Hits	674	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM9_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.051411 (rank : 182)
Query Neighborhood Hits	94	Target Neighborhood Hits	294	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TRIM9_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.051990 (rank : 180)
Query Neighborhood Hits	94	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

TTP_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.055242 (rank : 170)
Query Neighborhood Hits	94	Target Neighborhood Hits	86	Shared Neighborhood Hits	9
SwissProt Accessions	P26651	Gene names	ZFP36, G0S24, TIS11A, TTP
Domain Architecture
Description	Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth factor-inducible nuclear protein NUP475) (G0/G1 switch regulatory protein 24).

UHRF1_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.055077 (rank : 171)
Query Neighborhood Hits	94	Target Neighborhood Hits	272	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

ZN179_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.077036 (rank : 84)
Query Neighborhood Hits	94	Target Neighborhood Hits	178	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

Hits sorted by NC score

SIAH2_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.26429e-159 (rank : 1)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	94
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
NC score	0.995915 (rank : 2)	θ value	5.21151e-157 (rank : 2)
Query Neighborhood Hits	94	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

SIAH1_HUMAN
NC score	0.975877 (rank : 3)	θ value	1.86652e-130 (rank : 4)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	49
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SIA1A_MOUSE
NC score	0.975414 (rank : 4)	θ value	8.37844e-131 (rank : 3)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	48
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIA1B_MOUSE
NC score	0.975194 (rank : 5)	θ value	2.69525e-129 (rank : 5)
Query Neighborhood Hits	94	Target Neighborhood Hits	69	Shared Neighborhood Hits	47
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

ZN313_MOUSE
NC score	0.313077 (rank : 6)	θ value	1.43324e-05 (rank : 11)
Query Neighborhood Hits	94	Target Neighborhood Hits	273	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

ZN313_HUMAN
NC score	0.282461 (rank : 7)	θ value	0.000158464 (rank : 12)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

BIRC7_HUMAN
NC score	0.252075 (rank : 8)	θ value	0.00390308 (rank : 15)
Query Neighborhood Hits	94	Target Neighborhood Hits	185	Shared Neighborhood Hits	54
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

RN166_MOUSE
NC score	0.249828 (rank : 9)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	94	Target Neighborhood Hits	248	Shared Neighborhood Hits	53
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN166_HUMAN
NC score	0.235755 (rank : 10)	θ value	0.00665767 (rank : 17)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	53
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN152_MOUSE
NC score	0.190011 (rank : 11)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	94	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BG47	Gene names	Rnf152
Domain Architecture	No domain graphic available
Description	RING finger protein 152.

RN152_HUMAN
NC score	0.189557 (rank : 12)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	94	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q8N8N0	Gene names	RNF152
Domain Architecture
Description	RING finger protein 152.

TRAF7_MOUSE
NC score	0.188928 (rank : 13)	θ value	7.59969e-07 (rank : 6)
Query Neighborhood Hits	94	Target Neighborhood Hits	470	Shared Neighborhood Hits	53
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

PZRN3_HUMAN
NC score	0.185622 (rank : 14)	θ value	1.43324e-05 (rank : 10)
Query Neighborhood Hits	94	Target Neighborhood Hits	461	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

TRAF7_HUMAN
NC score	0.182048 (rank : 15)	θ value	2.21117e-06 (rank : 7)
Query Neighborhood Hits	94	Target Neighborhood Hits	482	Shared Neighborhood Hits	53
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

PZRN3_MOUSE
NC score	0.174702 (rank : 16)	θ value	0.000270298 (rank : 13)
Query Neighborhood Hits	94	Target Neighborhood Hits	447	Shared Neighborhood Hits	47
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RNF34_HUMAN
NC score	0.172968 (rank : 17)	θ value	0.163984 (rank : 33)
Query Neighborhood Hits	94	Target Neighborhood Hits	153	Shared Neighborhood Hits	40
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
NC score	0.172927 (rank : 18)	θ value	0.163984 (rank : 34)
Query Neighborhood Hits	94	Target Neighborhood Hits	160	Shared Neighborhood Hits	40
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RN125_MOUSE
NC score	0.168741 (rank : 19)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	94	Target Neighborhood Hits	220	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RNF41_MOUSE
NC score	0.168510 (rank : 20)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	94	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_HUMAN
NC score	0.168438 (rank : 21)	θ value	0.0431538 (rank : 24)
Query Neighborhood Hits	94	Target Neighborhood Hits	226	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

BIRC3_MOUSE
NC score	0.163293 (rank : 22)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	94	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

TRAF6_MOUSE
NC score	0.160060 (rank : 23)	θ value	0.279714 (rank : 42)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	46
SwissProt Accessions	P70196, Q8BLV2	Gene names	Traf6
Domain Architecture
Description	TNF receptor-associated factor 6.

PZRN4_HUMAN
NC score	0.159317 (rank : 24)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	94	Target Neighborhood Hits	438	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

TRAF6_HUMAN
NC score	0.158712 (rank : 25)	θ value	0.21417 (rank : 36)
Query Neighborhood Hits	94	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y4K3, Q8NEH5	Gene names	TRAF6, RNF85
Domain Architecture
Description	TNF receptor-associated factor 6 (Interleukin 1 signal transducer) (RING finger protein 85).

TRI50_HUMAN
NC score	0.158340 (rank : 26)	θ value	2.88788e-06 (rank : 8)
Query Neighborhood Hits	94	Target Neighborhood Hits	294	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

BIRC2_MOUSE
NC score	0.157645 (rank : 27)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	94	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

TRI50_MOUSE
NC score	0.155953 (rank : 28)	θ value	6.43352e-06 (rank : 9)
Query Neighborhood Hits	94	Target Neighborhood Hits	326	Shared Neighborhood Hits	72
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

BRCA1_HUMAN
NC score	0.154649 (rank : 29)	θ value	0.279714 (rank : 39)
Query Neighborhood Hits	94	Target Neighborhood Hits	381	Shared Neighborhood Hits	58
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

BRCA1_MOUSE
NC score	0.153353 (rank : 30)	θ value	0.0330416 (rank : 21)
Query Neighborhood Hits	94	Target Neighborhood Hits	436	Shared Neighborhood Hits	60
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

BIRC2_HUMAN
NC score	0.152243 (rank : 31)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	94	Target Neighborhood Hits	142	Shared Neighborhood Hits	43
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC3_HUMAN
NC score	0.145535 (rank : 32)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	94	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

RFFL_MOUSE
NC score	0.137113 (rank : 33)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	94	Target Neighborhood Hits	145	Shared Neighborhood Hits	38
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.135994 (rank : 34)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	94	Target Neighborhood Hits	175	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

NEUL1_HUMAN
NC score	0.133242 (rank : 35)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	94	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

RN125_HUMAN
NC score	0.132475 (rank : 36)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	94	Target Neighborhood Hits	230	Shared Neighborhood Hits	48
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

NEURL_MOUSE
NC score	0.131083 (rank : 37)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	94	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

TRAF4_HUMAN
NC score	0.129610 (rank : 38)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	94	Target Neighborhood Hits	373	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BUZ4, O75615, Q14848, Q2PJN8	Gene names	TRAF4, CART1, MLN62, RNF83
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Malignant 62) (RING finger protein 83).

RNF4_HUMAN
NC score	0.128638 (rank : 39)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	94	Target Neighborhood Hits	212	Shared Neighborhood Hits	48
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
NC score	0.127009 (rank : 40)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	94	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

TRAF5_MOUSE
NC score	0.127003 (rank : 41)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	94	Target Neighborhood Hits	355	Shared Neighborhood Hits	39
SwissProt Accessions	P70191, Q61480	Gene names	Traf5
Domain Architecture
Description	TNF receptor-associated factor 5.

RING1_HUMAN
NC score	0.121417 (rank : 42)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	94	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
NC score	0.119640 (rank : 43)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	94	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

MIB2_HUMAN
NC score	0.119223 (rank : 44)	θ value	0.00509761 (rank : 16)
Query Neighborhood Hits	94	Target Neighborhood Hits	438	Shared Neighborhood Hits	47
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

BIRC8_HUMAN
NC score	0.117768 (rank : 45)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	94	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

MIB2_MOUSE
NC score	0.116483 (rank : 46)	θ value	0.0148317 (rank : 18)
Query Neighborhood Hits	94	Target Neighborhood Hits	409	Shared Neighborhood Hits	47
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

TRAF4_MOUSE
NC score	0.116277 (rank : 47)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	94	Target Neighborhood Hits	338	Shared Neighborhood Hits	32
SwissProt Accessions	Q61382	Gene names	Traf4, Cart1
Domain Architecture
Description	TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1).

TRI32_MOUSE
NC score	0.115494 (rank : 48)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	94	Target Neighborhood Hits	271	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI32_HUMAN
NC score	0.115045 (rank : 49)	θ value	0.125558 (rank : 29)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	45
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI26_MOUSE
NC score	0.105691 (rank : 50)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	94	Target Neighborhood Hits	339	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI73_HUMAN
NC score	0.102315 (rank : 51)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	94	Target Neighborhood Hits	258	Shared Neighborhood Hits	59
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI26_HUMAN
NC score	0.102280 (rank : 52)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	94	Target Neighborhood Hits	335	Shared Neighborhood Hits	70
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRIM4_HUMAN
NC score	0.098391 (rank : 53)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	94	Target Neighborhood Hits	321	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRI74_HUMAN
NC score	0.098292 (rank : 54)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	94	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

BIRC4_HUMAN
NC score	0.095758 (rank : 55)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
NC score	0.095311 (rank : 56)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	32
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

TRAF5_HUMAN
NC score	0.094419 (rank : 57)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	94	Target Neighborhood Hits	396	Shared Neighborhood Hits	32
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

MIB1_HUMAN
NC score	0.093354 (rank : 58)	θ value	0.0252991 (rank : 19)
Query Neighborhood Hits	94	Target Neighborhood Hits	470	Shared Neighborhood Hits	45
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
NC score	0.093324 (rank : 59)	θ value	0.0252991 (rank : 20)
Query Neighborhood Hits	94	Target Neighborhood Hits	471	Shared Neighborhood Hits	45
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

TRAF3_HUMAN
NC score	0.092514 (rank : 60)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	94	Target Neighborhood Hits	463	Shared Neighborhood Hits	38
SwissProt Accessions	Q13114, Q12990, Q13076, Q13947, Q6AZX1, Q9UNL1	Gene names	TRAF3, CAP1, CRAF1
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein) (LAP1) (CAP-1).

RING2_HUMAN
NC score	0.091277 (rank : 61)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	94	Target Neighborhood Hits	201	Shared Neighborhood Hits	39
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
NC score	0.091272 (rank : 62)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	94	Target Neighborhood Hits	199	Shared Neighborhood Hits	39
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

TRI12_MOUSE
NC score	0.089995 (rank : 63)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	94	Target Neighborhood Hits	387	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

PEX10_HUMAN
NC score	0.089733 (rank : 64)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

RO52_HUMAN
NC score	0.088777 (rank : 65)	θ value	0.279714 (rank : 40)
Query Neighborhood Hits	94	Target Neighborhood Hits	419	Shared Neighborhood Hits	71
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

RN185_HUMAN
NC score	0.088005 (rank : 66)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	94	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRAF3_MOUSE
NC score	0.086989 (rank : 67)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	94	Target Neighborhood Hits	476	Shared Neighborhood Hits	36
SwissProt Accessions	Q60803, Q62380	Gene names	Traf3, Craf1, Trafamn
Domain Architecture
Description	TNF receptor-associated factor 3 (CD40 receptor-associated factor 1) (CRAF1) (TRAFAMN).

RN185_MOUSE
NC score	0.086654 (rank : 68)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	94	Target Neighborhood Hits	211	Shared Neighborhood Hits	54
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN168_HUMAN
NC score	0.085503 (rank : 69)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	94	Target Neighborhood Hits	370	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RAD18_MOUSE
NC score	0.083899 (rank : 70)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	94	Target Neighborhood Hits	230	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

TRI59_MOUSE
NC score	0.083430 (rank : 71)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	48
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI31_HUMAN
NC score	0.083374 (rank : 72)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	94	Target Neighborhood Hits	299	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI59_HUMAN
NC score	0.083163 (rank : 73)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	94	Target Neighborhood Hits	307	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI65_MOUSE
NC score	0.081682 (rank : 74)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	94	Target Neighborhood Hits	340	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

RN168_MOUSE
NC score	0.081164 (rank : 75)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	94	Target Neighborhood Hits	440	Shared Neighborhood Hits	56
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI65_HUMAN
NC score	0.081085 (rank : 76)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	94	Target Neighborhood Hits	330	Shared Neighborhood Hits	53
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRIM3_HUMAN
NC score	0.079800 (rank : 77)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	94	Target Neighborhood Hits	357	Shared Neighborhood Hits	50
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRI52_HUMAN
NC score	0.079149 (rank : 78)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	94	Target Neighborhood Hits	213	Shared Neighborhood Hits	56
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

RFPL2_HUMAN
NC score	0.078765 (rank : 79)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	94	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

TRI13_MOUSE
NC score	0.078328 (rank : 80)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	94	Target Neighborhood Hits	282	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI40_HUMAN
NC score	0.078029 (rank : 81)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	94	Target Neighborhood Hits	279	Shared Neighborhood Hits	55
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI25_MOUSE
NC score	0.077364 (rank : 82)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	94	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

RFWD2_MOUSE
NC score	0.077125 (rank : 83)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	94	Target Neighborhood Hits	535	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

ZN179_HUMAN
NC score	0.077036 (rank : 84)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	94	Target Neighborhood Hits	178	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

TRAF2_MOUSE
NC score	0.076994 (rank : 85)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	94	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

TRI13_HUMAN
NC score	0.076978 (rank : 86)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	94	Target Neighborhood Hits	274	Shared Neighborhood Hits	49
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

RAD18_HUMAN
NC score	0.076655 (rank : 87)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	94	Target Neighborhood Hits	284	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS91, Q58F55, Q9NRT6	Gene names	RAD18, RNF73
Domain Architecture
Description	Postreplication repair protein RAD18 (hRAD18) (hHR18) (RING finger protein 73).

RFWD2_HUMAN
NC score	0.076603 (rank : 88)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	94	Target Neighborhood Hits	518	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RNF26_HUMAN
NC score	0.076429 (rank : 89)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

TRI35_HUMAN
NC score	0.076338 (rank : 90)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	94	Target Neighborhood Hits	382	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

RNF5_MOUSE
NC score	0.076042 (rank : 91)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

RNF5_HUMAN
NC score	0.076015 (rank : 92)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	52
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RAG1_MOUSE
NC score	0.075962 (rank : 93)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	94	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	P15919	Gene names	Rag1, Rag-1
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1).

RAG1_HUMAN
NC score	0.075507 (rank : 94)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	94	Target Neighborhood Hits	203	Shared Neighborhood Hits	42
SwissProt Accessions	P15918, Q8NER2	Gene names	RAG1, RNF74
Domain Architecture
Description	V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74).

TRI11_HUMAN
NC score	0.074978 (rank : 95)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	94	Target Neighborhood Hits	316	Shared Neighborhood Hits	62
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI35_MOUSE
NC score	0.074892 (rank : 96)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	94	Target Neighborhood Hits	465	Shared Neighborhood Hits	58
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI11_MOUSE
NC score	0.074807 (rank : 97)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	94	Target Neighborhood Hits	329	Shared Neighborhood Hits	62
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

RKHD1_HUMAN
NC score	0.074318 (rank : 98)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	94	Target Neighborhood Hits	163	Shared Neighborhood Hits	40
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

TRIM5_HUMAN
NC score	0.072776 (rank : 99)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	94	Target Neighborhood Hits	424	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRI68_MOUSE
NC score	0.072672 (rank : 100)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	94	Target Neighborhood Hits	356	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

TRI60_HUMAN
NC score	0.072383 (rank : 101)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	94	Target Neighborhood Hits	357	Shared Neighborhood Hits	65
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

RNF8_MOUSE
NC score	0.072271 (rank : 102)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	94	Target Neighborhood Hits	618	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

TRI25_HUMAN
NC score	0.071665 (rank : 103)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	94	Target Neighborhood Hits	472	Shared Neighborhood Hits	56
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

RC3H1_MOUSE
NC score	0.071628 (rank : 104)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	94	Target Neighborhood Hits	244	Shared Neighborhood Hits	42
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

TRI22_HUMAN
NC score	0.071296 (rank : 105)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	94	Target Neighborhood Hits	396	Shared Neighborhood Hits	57
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI27_MOUSE
NC score	0.071135 (rank : 106)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	94	Target Neighborhood Hits	261	Shared Neighborhood Hits	62
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRIM8_HUMAN
NC score	0.070583 (rank : 107)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	94	Target Neighborhood Hits	650	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRI10_HUMAN
NC score	0.070137 (rank : 108)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	94	Target Neighborhood Hits	315	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRIM8_MOUSE
NC score	0.070044 (rank : 109)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	94	Target Neighborhood Hits	674	Shared Neighborhood Hits	51
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

RO52_MOUSE
NC score	0.069787 (rank : 110)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	94	Target Neighborhood Hits	360	Shared Neighborhood Hits	65
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

CM007_MOUSE
NC score	0.069729 (rank : 111)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	94	Target Neighborhood Hits	416	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K2Y0, Q9CYU1, Q9D1Y0	Gene names
Domain Architecture	No domain graphic available
Description	Protein C13orf7 homolog.

RNF8_HUMAN
NC score	0.069152 (rank : 112)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	94	Target Neighborhood Hits	622	Shared Neighborhood Hits	62
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRIM6_HUMAN
NC score	0.068981 (rank : 113)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	94	Target Neighborhood Hits	412	Shared Neighborhood Hits	56
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

TRI30_MOUSE
NC score	0.068870 (rank : 114)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	94	Target Neighborhood Hits	434	Shared Neighborhood Hits	50
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

RC3H1_HUMAN
NC score	0.068867 (rank : 115)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	94	Target Neighborhood Hits	433	Shared Neighborhood Hits	43
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

TRI18_MOUSE
NC score	0.067960 (rank : 116)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRIM6_MOUSE
NC score	0.067750 (rank : 117)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	94	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRI68_HUMAN
NC score	0.067591 (rank : 118)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	94	Target Neighborhood Hits	267	Shared Neighborhood Hits	53
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

RN183_HUMAN
NC score	0.067461 (rank : 119)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	94	Target Neighborhood Hits	126	Shared Neighborhood Hits	34
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

TRI47_MOUSE
NC score	0.067377 (rank : 120)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	94	Target Neighborhood Hits	295	Shared Neighborhood Hits	56
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI10_MOUSE
NC score	0.067304 (rank : 121)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	94	Target Neighborhood Hits	285	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI17_HUMAN
NC score	0.067187 (rank : 122)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	94	Target Neighborhood Hits	318	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI18_HUMAN
NC score	0.067074 (rank : 123)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	94	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI39_MOUSE
NC score	0.066676 (rank : 124)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	94	Target Neighborhood Hits	691	Shared Neighborhood Hits	63
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRIM7_MOUSE
NC score	0.066468 (rank : 125)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	94	Target Neighborhood Hits	358	Shared Neighborhood Hits	47
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRI39_HUMAN
NC score	0.066344 (rank : 126)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	94	Target Neighborhood Hits	693	Shared Neighborhood Hits	64
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI47_HUMAN
NC score	0.066293 (rank : 127)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	94	Target Neighborhood Hits	286	Shared Neighborhood Hits	52
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRIM7_HUMAN
NC score	0.065952 (rank : 128)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	94	Target Neighborhood Hits	336	Shared Neighborhood Hits	45
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRI27_HUMAN
NC score	0.065876 (rank : 129)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	94	Target Neighborhood Hits	273	Shared Neighborhood Hits	62
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

PDZK4_HUMAN
NC score	0.065722 (rank : 130)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q76G19, Q8NB75, Q9BUH9, Q9P284	Gene names	PDZK4, KIAA1444, PDZRN4L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

TRI43_HUMAN
NC score	0.065578 (rank : 131)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	94	Target Neighborhood Hits	341	Shared Neighborhood Hits	58
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI62_MOUSE
NC score	0.065566 (rank : 132)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	94	Target Neighborhood Hits	478	Shared Neighborhood Hits	46
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

PDZK4_MOUSE
NC score	0.065404 (rank : 133)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QY39, Q6PHP2	Gene names	Pdzk4, Pdzrn4l, Xlu
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein).

TRI48_HUMAN
NC score	0.065046 (rank : 134)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	94	Target Neighborhood Hits	192	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

RN183_MOUSE
NC score	0.064898 (rank : 135)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	94	Target Neighborhood Hits	119	Shared Neighborhood Hits	32
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

TRIM1_HUMAN
NC score	0.064658 (rank : 136)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	94	Target Neighborhood Hits	345	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRI34_HUMAN
NC score	0.064640 (rank : 137)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	94	Target Neighborhood Hits	416	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRIM2_HUMAN
NC score	0.064630 (rank : 138)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	94	Target Neighborhood Hits	330	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM3_MOUSE
NC score	0.064597 (rank : 139)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	94	Target Neighborhood Hits	351	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRI38_HUMAN
NC score	0.064556 (rank : 140)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	94	Target Neighborhood Hits	373	Shared Neighborhood Hits	56
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRAF2_HUMAN
NC score	0.064189 (rank : 141)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	94	Target Neighborhood Hits	402	Shared Neighborhood Hits	29
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

TRIM2_MOUSE
NC score	0.064097 (rank : 142)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	94	Target Neighborhood Hits	331	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRIM1_MOUSE
NC score	0.063777 (rank : 143)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	94	Target Neighborhood Hits	361	Shared Neighborhood Hits	48
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

TRI54_HUMAN
NC score	0.063567 (rank : 144)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	94	Target Neighborhood Hits	209	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI62_HUMAN
NC score	0.063188 (rank : 145)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	94	Target Neighborhood Hits	584	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

UB7I1_HUMAN
NC score	0.061990 (rank : 146)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	94	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

TRI17_MOUSE
NC score	0.061349 (rank : 147)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	94	Target Neighborhood Hits	620	Shared Neighborhood Hits	55
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

MYLIP_HUMAN
NC score	0.061271 (rank : 148)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	94	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

TRI60_MOUSE
NC score	0.060681 (rank : 149)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRI41_HUMAN
NC score	0.060378 (rank : 150)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	94	Target Neighborhood Hits	349	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRAF1_HUMAN
NC score	0.060308 (rank : 151)	θ value	0.365318 (rank : 43)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	8
SwissProt Accessions	Q13077, Q8NF13	Gene names	TRAF1, EBI6
Domain Architecture
Description	TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6).

RNF39_HUMAN
NC score	0.060219 (rank : 152)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	94	Target Neighborhood Hits	200	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

TRI15_HUMAN
NC score	0.060192 (rank : 153)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	94	Target Neighborhood Hits	395	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

CM007_HUMAN
NC score	0.060168 (rank : 154)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	94	Target Neighborhood Hits	422	Shared Neighborhood Hits	27
SwissProt Accessions	Q5W0B1, Q8TBY2, Q9H0T2, Q9H8M0	Gene names	C13orf7
Domain Architecture	No domain graphic available
Description	Protein C13orf7.

R113A_HUMAN
NC score	0.060019 (rank : 155)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	94	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

TRI54_MOUSE
NC score	0.059959 (rank : 156)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	94	Target Neighborhood Hits	197	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

UB7I1_MOUSE
NC score	0.059797 (rank : 157)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	94	Target Neighborhood Hits	206	Shared Neighborhood Hits	8
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

TRI55_HUMAN
NC score	0.059593 (rank : 158)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	94	Target Neighborhood Hits	292	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

R113B_HUMAN
NC score	0.059341 (rank : 159)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZP6, Q8WWF9, Q96QY9	Gene names	RNF113B, RNF161, ZNF183L1
Domain Architecture
Description	RING finger protein 113B (Zinc finger protein 183-like 1).

BFAR_HUMAN
NC score	0.059194 (rank : 160)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	94	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

TRI56_HUMAN
NC score	0.058709 (rank : 161)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	94	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI49_HUMAN
NC score	0.058100 (rank : 162)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	94	Target Neighborhood Hits	199	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

RFPL3_HUMAN
NC score	0.057831 (rank : 163)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	94	Target Neighborhood Hits	134	Shared Neighborhood Hits	32
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

BFAR_MOUSE
NC score	0.057496 (rank : 164)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	94	Target Neighborhood Hits	232	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRI34_MOUSE
NC score	0.056752 (rank : 165)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	94	Target Neighborhood Hits	332	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI63_MOUSE
NC score	0.056727 (rank : 166)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	94	Target Neighborhood Hits	240	Shared Neighborhood Hits	39
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

CHFR_HUMAN
NC score	0.056285 (rank : 167)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	42
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

LNX1_MOUSE
NC score	0.056145 (rank : 168)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	94	Target Neighborhood Hits	377	Shared Neighborhood Hits	43
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

TRI63_HUMAN
NC score	0.055665 (rank : 169)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	94	Target Neighborhood Hits	298	Shared Neighborhood Hits	40
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TTP_HUMAN
NC score	0.055242 (rank : 170)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	94	Target Neighborhood Hits	86	Shared Neighborhood Hits	9
SwissProt Accessions	P26651	Gene names	ZFP36, G0S24, TIS11A, TTP
Domain Architecture
Description	Tristetraproline (TTP) (Zinc finger protein 36 homolog) (Zfp-36) (TIS11A protein) (TIS11) (Growth factor-inducible nuclear protein NUP475) (G0/G1 switch regulatory protein 24).

UHRF1_HUMAN
NC score	0.055077 (rank : 171)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	94	Target Neighborhood Hits	272	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

NHLC1_MOUSE
NC score	0.054849 (rank : 172)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	94	Target Neighborhood Hits	103	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BR37	Gene names	Nhlrc1, Epm2b
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

RFPL1_HUMAN
NC score	0.054613 (rank : 173)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	94	Target Neighborhood Hits	119	Shared Neighborhood Hits	27
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

LNX1_HUMAN
NC score	0.054416 (rank : 174)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	94	Target Neighborhood Hits	379	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

TRI56_MOUSE
NC score	0.054037 (rank : 175)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	94	Target Neighborhood Hits	255	Shared Neighborhood Hits	48
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

CHFR_MOUSE
NC score	0.053779 (rank : 176)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	94	Target Neighborhood Hits	264	Shared Neighborhood Hits	44
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

NHLC1_HUMAN
NC score	0.053715 (rank : 177)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	94	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q6VVB1, Q6IMH1	Gene names	NHLRC1, EPM2B
Domain Architecture	No domain graphic available
Description	NHL repeat-containing protein 1 (Malin).

LRSM1_MOUSE
NC score	0.053606 (rank : 178)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	94	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

LNX2_MOUSE
NC score	0.052954 (rank : 179)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	94	Target Neighborhood Hits	407	Shared Neighborhood Hits	45
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

TRIM9_MOUSE
NC score	0.051990 (rank : 180)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	94	Target Neighborhood Hits	274	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

LNX2_HUMAN
NC score	0.051946 (rank : 181)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	94	Target Neighborhood Hits	389	Shared Neighborhood Hits	45
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

TRIM9_HUMAN
NC score	0.051411 (rank : 182)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	94	Target Neighborhood Hits	294	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

TRI46_HUMAN
NC score	0.050301 (rank : 183)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	94	Target Neighborhood Hits	291	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

MGRN1_HUMAN
NC score	0.050282 (rank : 184)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	94	Target Neighborhood Hits	192	Shared Neighborhood Hits	37
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

TRI46_MOUSE
NC score	0.050160 (rank : 185)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	94	Target Neighborhood Hits	287	Shared Neighborhood Hits	51
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

LRSM1_HUMAN
NC score	0.046885 (rank : 186)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	94	Target Neighborhood Hits	1078	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

BAT2_HUMAN
NC score	0.045902 (rank : 187)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	94	Target Neighborhood Hits	931	Shared Neighborhood Hits	14
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CIC_MOUSE
NC score	0.040571 (rank : 188)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	94	Target Neighborhood Hits	742	Shared Neighborhood Hits	15
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

ARD1_MOUSE
NC score	0.039800 (rank : 189)	θ value	0.279714 (rank : 38)
Query Neighborhood Hits	94	Target Neighborhood Hits	573	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BGX0, Q8C2B6, Q8CDA4, Q8CDA7	Gene names	Trim23, Arfd1
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23).

BAT2_MOUSE
NC score	0.037129 (rank : 190)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	94	Target Neighborhood Hits	947	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

I17RA_HUMAN
NC score	0.037065 (rank : 191)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	94	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q96F46, O43844	Gene names	IL17RA, IL17R
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor A precursor (IL-17 receptor).

CIC_HUMAN
NC score	0.034183 (rank : 192)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	94	Target Neighborhood Hits	992	Shared Neighborhood Hits	15
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

ARD1_HUMAN
NC score	0.030540 (rank : 193)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	94	Target Neighborhood Hits	621	Shared Neighborhood Hits	21
SwissProt Accessions	P36406, Q9BZY4, Q9BZY5	Gene names	TRIM23, ARD1, ARFD1, RNF46
Domain Architecture
Description	GTP-binding protein ARD-1 (ADP-ribosylation factor domain protein 1) (Tripartite motif-containing protein 23) (RING finger protein 46).

MUC1_HUMAN
NC score	0.026444 (rank : 194)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	94	Target Neighborhood Hits	975	Shared Neighborhood Hits	12
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

OGFR_HUMAN
NC score	0.017536 (rank : 195)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	94	Target Neighborhood Hits	1582	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BAT3_HUMAN
NC score	0.017035 (rank : 196)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	94	Target Neighborhood Hits	490	Shared Neighborhood Hits	11
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

CRCM1_HUMAN
NC score	0.014276 (rank : 197)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q96D31, Q3MHV3, Q6DHX2, Q96BP7, Q96K71	Gene names	TMEM142A, CRACM1, ORAI1
Domain Architecture	No domain graphic available
Description	Calcium release-activated calcium channel protein 1 (Transmembrane protein 142A) (Protein orai-1).

RGS3_HUMAN
NC score	0.010652 (rank : 198)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	94	Target Neighborhood Hits	1375	Shared Neighborhood Hits	14
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

GATA6_HUMAN
NC score	0.008813 (rank : 199)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	94	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

LPP_HUMAN
NC score	0.006201 (rank : 200)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	94	Target Neighborhood Hits	775	Shared Neighborhood Hits	9
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

CO2A1_MOUSE
NC score	0.005160 (rank : 201)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	94	Target Neighborhood Hits	483	Shared Neighborhood Hits	12
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO2A1_HUMAN
NC score	0.005128 (rank : 202)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	94	Target Neighborhood Hits	486	Shared Neighborhood Hits	12
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

BAZ2A_HUMAN
NC score	0.005018 (rank : 203)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	94	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

DNER_HUMAN
NC score	0.004742 (rank : 204)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	94	Target Neighborhood Hits	460	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFT8, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2	Gene names	DNER, BET
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor.

ERBB2_HUMAN
NC score	0.000483 (rank : 205)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	94	Target Neighborhood Hits	1073	Shared Neighborhood Hits	3
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).