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Network neighborhood for query Sequence : NPAS3_HUMAN

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NPAS3_HUMAN
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPAS3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	0 (rank : 2)	NC score	0.996604 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	103	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
θ value	3.41741e-116 (rank : 3)	NC score	0.970903 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	1.69605e-115 (rank : 4)	NC score	0.971139 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

SIM2_HUMAN
θ value	2.0926e-81 (rank : 5)	NC score	0.946602 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	4.66183e-81 (rank : 6)	NC score	0.944354 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
θ value	3.34088e-79 (rank : 7)	NC score	0.938817 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	62	Shared Neighborhood Hits	37
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	2.1655e-78 (rank : 8)	NC score	0.938104 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	37
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_HUMAN
θ value	8.55514e-59 (rank : 9)	NC score	0.905775 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_MOUSE
θ value	1.36585e-56 (rank : 10)	NC score	0.899765 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_MOUSE
θ value	1.36585e-56 (rank : 11)	NC score	0.907626 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

EPAS1_HUMAN
θ value	3.974e-56 (rank : 12)	NC score	0.900651 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

AHR_HUMAN
θ value	2.77775e-25 (rank : 13)	NC score	0.815377 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	1.80048e-24 (rank : 14)	NC score	0.810915 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
θ value	1.5242e-23 (rank : 15)	NC score	0.754424 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	9.87957e-23 (rank : 16)	NC score	0.751635 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT_HUMAN
θ value	5.60996e-18 (rank : 17)	NC score	0.694427 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_HUMAN
θ value	7.32683e-18 (rank : 18)	NC score	0.719957 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	9.56915e-18 (rank : 19)	NC score	0.717795 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT_MOUSE
θ value	1.63225e-17 (rank : 20)	NC score	0.682043 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	213	Shared Neighborhood Hits	37
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
θ value	4.02038e-16 (rank : 21)	NC score	0.702335 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	8.95645e-16 (rank : 22)	NC score	0.700658 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NPAS2_MOUSE
θ value	1.86753e-13 (rank : 23)	NC score	0.690279 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
θ value	5.43371e-13 (rank : 24)	NC score	0.682649 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	150	Shared Neighborhood Hits	36
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NCOA1_HUMAN
θ value	2.69671e-12 (rank : 25)	NC score	0.596109 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	2.69671e-12 (rank : 26)	NC score	0.598693 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	196	Shared Neighborhood Hits	36
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NPAS4_HUMAN
θ value	7.84624e-12 (rank : 27)	NC score	0.651338 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	214	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	1.02475e-11 (rank : 28)	NC score	0.638330 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA2_HUMAN
θ value	6.21693e-09 (rank : 29)	NC score	0.527663 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	1.06045e-08 (rank : 30)	NC score	0.526521 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	7.59969e-07 (rank : 31)	NC score	0.521640 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	6.43352e-06 (rank : 32)	NC score	0.486245 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

LEO1_MOUSE
θ value	0.00390308 (rank : 33)	NC score	0.057558 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TXND2_MOUSE
θ value	0.00390308 (rank : 34)	NC score	0.049798 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	828	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

NKTR_HUMAN
θ value	0.00869519 (rank : 35)	NC score	0.042869 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	658	Shared Neighborhood Hits	18
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

LEO1_HUMAN
θ value	0.0330416 (rank : 36)	NC score	0.048342 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

ZN483_HUMAN
θ value	0.21417 (rank : 37)	NC score	-0.001324 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	785	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TF39	Gene names	ZNF483, KIAA1962
Domain Architecture
Description	Zinc finger protein 483.

MYCD_HUMAN
θ value	0.279714 (rank : 38)	NC score	0.030399 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

RPTN_MOUSE
θ value	0.279714 (rank : 39)	NC score	0.022269 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	650	Shared Neighborhood Hits	16
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

IWS1_MOUSE
θ value	0.47712 (rank : 40)	NC score	0.034290 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	1258	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LPIN2_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.024297 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

MIA2_HUMAN
θ value	0.47712 (rank : 42)	NC score	0.044942 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PC5, Q9H6C1	Gene names	MIA2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

JHD2A_MOUSE
θ value	0.62314 (rank : 43)	NC score	0.021146 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

NIPBL_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.020345 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	1311	Shared Neighborhood Hits	27
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PZRN4_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.012703 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

NC6IP_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.043265 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

AFTIN_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.018868 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	Q80WT5, Q5SSE6, Q99KJ1	Gene names	Aftph, Afth
Domain Architecture	No domain graphic available
Description	Aftiphilin.

C8AP2_MOUSE
θ value	1.81305 (rank : 48)	NC score	0.025854 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	405	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

IWS1_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.027817 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	1241	Shared Neighborhood Hits	27
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LARP1_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.022055 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

MATR3_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.026875 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

RAI1_HUMAN
θ value	2.36792 (rank : 52)	NC score	0.011316 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SOCS6_MOUSE
θ value	2.36792 (rank : 53)	NC score	0.010442 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SMRC1_MOUSE
θ value	3.0926 (rank : 54)	NC score	0.021030 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	459	Shared Neighborhood Hits	19
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

BSCL2_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.023881 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

DMP1_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.038381 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	498	Shared Neighborhood Hits	24
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

HEY2_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.101841 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.100058 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAST4_HUMAN
θ value	4.03905 (rank : 59)	NC score	-0.002488 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	1804	Shared Neighborhood Hits	16
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MCES_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.020939 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

TBX2_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.004110 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

VPS72_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.013762 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

ATAD2_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.007790 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	322	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

GCP5_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.019095 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q96RT8, Q96PY8	Gene names	TUBGCP5, GCP5, KIAA1899
Domain Architecture
Description	Gamma-tubulin complex component 5 (GCP-5).

HEY1_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.091564 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.095009 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

NC6IP_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.030036 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

OS9_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.028693 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

PDE1C_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.007677 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PER1_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.171833 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

TIAM1_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.008526 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TSP1_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.006024 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	6
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP3_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.005592 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	250	Shared Neighborhood Hits	6
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

DSG1C_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.003186 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSF0, Q7TQ61	Gene names	Dsg1c, Dsg6
Domain Architecture	No domain graphic available
Description	Desmoglein-1 gamma precursor (Dsg1-gamma) (Desmoglein-6).

MMS19_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.012715 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D071, Q925N8, Q9CWX3	Gene names	Mms19l, Mms19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (MET18 homolog).

TSP1_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.005337 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	6
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

ZBT40_HUMAN
θ value	6.88961 (rank : 77)	NC score	-0.001752 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	949	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

ESCO1_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.009590 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	361	Shared Neighborhood Hits	8
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

FA35A_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.008680 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UEN2	Gene names	Fam35a
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

SRGP2_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.001274 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	331	Shared Neighborhood Hits	3
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

WHRN_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.005038 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	412	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

HES5_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.061048 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MITF_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.062481 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.063754 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.058510 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.058502 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PER1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.173251 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	215	Shared Neighborhood Hits	24
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.176599 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.158886 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.166333 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	479	Shared Neighborhood Hits	25
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER3_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.189462 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

TCFL5_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.063824 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.062120 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.059718 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.059686 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	119	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.058265 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.058238 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	71	Shared Neighborhood Hits	12
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.056283 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.052539 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

NPAS3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	81	Target Neighborhood Hits	81	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.996604 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	81	Target Neighborhood Hits	103	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
NC score	0.971139 (rank : 3)	θ value	1.69605e-115 (rank : 4)
Query Neighborhood Hits	81	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.970903 (rank : 4)	θ value	3.41741e-116 (rank : 3)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

SIM2_HUMAN
NC score	0.946602 (rank : 5)	θ value	2.0926e-81 (rank : 5)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.944354 (rank : 6)	θ value	4.66183e-81 (rank : 6)
Query Neighborhood Hits	81	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.938817 (rank : 7)	θ value	3.34088e-79 (rank : 7)
Query Neighborhood Hits	81	Target Neighborhood Hits	62	Shared Neighborhood Hits	37
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.938104 (rank : 8)	θ value	2.1655e-78 (rank : 8)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	37
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_MOUSE
NC score	0.907626 (rank : 9)	θ value	1.36585e-56 (rank : 11)
Query Neighborhood Hits	81	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.905775 (rank : 10)	θ value	8.55514e-59 (rank : 9)
Query Neighborhood Hits	81	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_HUMAN
NC score	0.900651 (rank : 11)	θ value	3.974e-56 (rank : 12)
Query Neighborhood Hits	81	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.899765 (rank : 12)	θ value	1.36585e-56 (rank : 10)
Query Neighborhood Hits	81	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_HUMAN
NC score	0.815377 (rank : 13)	θ value	2.77775e-25 (rank : 13)
Query Neighborhood Hits	81	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.810915 (rank : 14)	θ value	1.80048e-24 (rank : 14)
Query Neighborhood Hits	81	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
NC score	0.754424 (rank : 15)	θ value	1.5242e-23 (rank : 15)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.751635 (rank : 16)	θ value	9.87957e-23 (rank : 16)
Query Neighborhood Hits	81	Target Neighborhood Hits	121	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
NC score	0.719957 (rank : 17)	θ value	7.32683e-18 (rank : 18)
Query Neighborhood Hits	81	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.717795 (rank : 18)	θ value	9.56915e-18 (rank : 19)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT2_HUMAN
NC score	0.702335 (rank : 19)	θ value	4.02038e-16 (rank : 21)
Query Neighborhood Hits	81	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.700658 (rank : 20)	θ value	8.95645e-16 (rank : 22)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.694427 (rank : 21)	θ value	5.60996e-18 (rank : 17)
Query Neighborhood Hits	81	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_MOUSE
NC score	0.690279 (rank : 22)	θ value	1.86753e-13 (rank : 23)
Query Neighborhood Hits	81	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.682649 (rank : 23)	θ value	5.43371e-13 (rank : 24)
Query Neighborhood Hits	81	Target Neighborhood Hits	150	Shared Neighborhood Hits	36
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_MOUSE
NC score	0.682043 (rank : 24)	θ value	1.63225e-17 (rank : 20)
Query Neighborhood Hits	81	Target Neighborhood Hits	213	Shared Neighborhood Hits	37
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
NC score	0.651338 (rank : 25)	θ value	7.84624e-12 (rank : 27)
Query Neighborhood Hits	81	Target Neighborhood Hits	214	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.638330 (rank : 26)	θ value	1.02475e-11 (rank : 28)
Query Neighborhood Hits	81	Target Neighborhood Hits	245	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.598693 (rank : 27)	θ value	2.69671e-12 (rank : 26)
Query Neighborhood Hits	81	Target Neighborhood Hits	196	Shared Neighborhood Hits	36
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.596109 (rank : 28)	θ value	2.69671e-12 (rank : 25)
Query Neighborhood Hits	81	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
NC score	0.527663 (rank : 29)	θ value	6.21693e-09 (rank : 29)
Query Neighborhood Hits	81	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
NC score	0.526521 (rank : 30)	θ value	1.06045e-08 (rank : 30)
Query Neighborhood Hits	81	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
NC score	0.521640 (rank : 31)	θ value	7.59969e-07 (rank : 31)
Query Neighborhood Hits	81	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.486245 (rank : 32)	θ value	6.43352e-06 (rank : 32)
Query Neighborhood Hits	81	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.189462 (rank : 33)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	81	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.176599 (rank : 34)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	81	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.173251 (rank : 35)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	81	Target Neighborhood Hits	215	Shared Neighborhood Hits	24
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.171833 (rank : 36)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	81	Target Neighborhood Hits	235	Shared Neighborhood Hits	22
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.166333 (rank : 37)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	81	Target Neighborhood Hits	479	Shared Neighborhood Hits	25
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.158886 (rank : 38)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.101841 (rank : 39)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	81	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.100058 (rank : 40)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	81	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.095009 (rank : 41)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	81	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.091564 (rank : 42)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	81	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

TCFL5_HUMAN
NC score	0.063824 (rank : 43)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	81	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MITF_MOUSE
NC score	0.063754 (rank : 44)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	81	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.062481 (rank : 45)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	81	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.062120 (rank : 46)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	81	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

HES5_MOUSE
NC score	0.061048 (rank : 47)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	81	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

TFEB_HUMAN
NC score	0.059718 (rank : 48)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	81	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.059686 (rank : 49)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	81	Target Neighborhood Hits	119	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MLX_HUMAN
NC score	0.058510 (rank : 50)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	81	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.058502 (rank : 51)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	81	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF1_HUMAN
NC score	0.058265 (rank : 52)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	81	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.058238 (rank : 53)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	81	Target Neighborhood Hits	71	Shared Neighborhood Hits	12
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

LEO1_MOUSE
NC score	0.057558 (rank : 54)	θ value	0.00390308 (rank : 33)
Query Neighborhood Hits	81	Target Neighborhood Hits	946	Shared Neighborhood Hits	30
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

USF2_HUMAN
NC score	0.056283 (rank : 55)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	81	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.052539 (rank : 56)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	81	Target Neighborhood Hits	173	Shared Neighborhood Hits	12
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

TXND2_MOUSE
NC score	0.049798 (rank : 57)	θ value	0.00390308 (rank : 34)
Query Neighborhood Hits	81	Target Neighborhood Hits	828	Shared Neighborhood Hits	18
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

LEO1_HUMAN
NC score	0.048342 (rank : 58)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	81	Target Neighborhood Hits	958	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MIA2_HUMAN
NC score	0.044942 (rank : 59)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	81	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q96PC5, Q9H6C1	Gene names	MIA2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

NC6IP_HUMAN
NC score	0.043265 (rank : 60)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	81	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

NKTR_HUMAN
NC score	0.042869 (rank : 61)	θ value	0.00869519 (rank : 35)
Query Neighborhood Hits	81	Target Neighborhood Hits	658	Shared Neighborhood Hits	18
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

DMP1_MOUSE
NC score	0.038381 (rank : 62)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	81	Target Neighborhood Hits	498	Shared Neighborhood Hits	24
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

IWS1_MOUSE
NC score	0.034290 (rank : 63)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	81	Target Neighborhood Hits	1258	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYCD_HUMAN
NC score	0.030399 (rank : 64)	θ value	0.279714 (rank : 38)
Query Neighborhood Hits	81	Target Neighborhood Hits	167	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IZQ8, Q8N7Q1	Gene names	MYOCD, MYCD
Domain Architecture
Description	Myocardin.

NC6IP_MOUSE
NC score	0.030036 (rank : 65)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	81	Target Neighborhood Hits	161	Shared Neighborhood Hits	11
SwissProt Accessions	Q923W1, Q6DI60, Q6PEA7, Q8R0W9	Gene names	Ncoa6ip, Pimt
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT).

OS9_HUMAN
NC score	0.028693 (rank : 66)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	9
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

IWS1_HUMAN
NC score	0.027817 (rank : 67)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	81	Target Neighborhood Hits	1241	Shared Neighborhood Hits	27
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MATR3_HUMAN
NC score	0.026875 (rank : 68)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	81	Target Neighborhood Hits	325	Shared Neighborhood Hits	16
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

C8AP2_MOUSE
NC score	0.025854 (rank : 69)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	81	Target Neighborhood Hits	405	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WUF3, Q9CSW2	Gene names	Casp8ap2, Flash
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

LPIN2_HUMAN
NC score	0.024297 (rank : 70)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	81	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

BSCL2_HUMAN
NC score	0.023881 (rank : 71)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	81	Target Neighborhood Hits	148	Shared Neighborhood Hits	8
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

RPTN_MOUSE
NC score	0.022269 (rank : 72)	θ value	0.279714 (rank : 39)
Query Neighborhood Hits	81	Target Neighborhood Hits	650	Shared Neighborhood Hits	16
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

LARP1_HUMAN
NC score	0.022055 (rank : 73)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	81	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PKG0, O94836, Q8N4M2, Q8NB73, Q9UFD7	Gene names	LARP1, KIAA0731, LARP
Domain Architecture	No domain graphic available
Description	La-related protein 1 (La ribonucleoprotein domain family member 1).

JHD2A_MOUSE
NC score	0.021146 (rank : 74)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	81	Target Neighborhood Hits	123	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

SMRC1_MOUSE
NC score	0.021030 (rank : 75)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	81	Target Neighborhood Hits	459	Shared Neighborhood Hits	19
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

MCES_HUMAN
NC score	0.020939 (rank : 76)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	7
SwissProt Accessions	O43148, O94996, Q9UIJ9	Gene names	RNMT, KIAA0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase) (hcm1p) (hCMT1) (hMet).

NIPBL_HUMAN
NC score	0.020345 (rank : 77)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	81	Target Neighborhood Hits	1311	Shared Neighborhood Hits	27
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

GCP5_HUMAN
NC score	0.019095 (rank : 78)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	81	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q96RT8, Q96PY8	Gene names	TUBGCP5, GCP5, KIAA1899
Domain Architecture
Description	Gamma-tubulin complex component 5 (GCP-5).

AFTIN_MOUSE
NC score	0.018868 (rank : 79)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	81	Target Neighborhood Hits	52	Shared Neighborhood Hits	7
SwissProt Accessions	Q80WT5, Q5SSE6, Q99KJ1	Gene names	Aftph, Afth
Domain Architecture	No domain graphic available
Description	Aftiphilin.

VPS72_MOUSE
NC score	0.013762 (rank : 80)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	81	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

MMS19_MOUSE
NC score	0.012715 (rank : 81)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	81	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D071, Q925N8, Q9CWX3	Gene names	Mms19l, Mms19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (MET18 homolog).

PZRN4_HUMAN
NC score	0.012703 (rank : 82)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	81	Target Neighborhood Hits	438	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RAI1_HUMAN
NC score	0.011316 (rank : 83)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	81	Target Neighborhood Hits	360	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SOCS6_MOUSE
NC score	0.010442 (rank : 84)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	81	Target Neighborhood Hits	146	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

ESCO1_HUMAN
NC score	0.009590 (rank : 85)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	81	Target Neighborhood Hits	361	Shared Neighborhood Hits	8
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

FA35A_MOUSE
NC score	0.008680 (rank : 86)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	81	Target Neighborhood Hits	54	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UEN2	Gene names	Fam35a
Domain Architecture	No domain graphic available
Description	Protein FAM35A.

TIAM1_MOUSE
NC score	0.008526 (rank : 87)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	81	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ATAD2_HUMAN
NC score	0.007790 (rank : 88)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	81	Target Neighborhood Hits	322	Shared Neighborhood Hits	15
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

PDE1C_HUMAN
NC score	0.007677 (rank : 89)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	81	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

TSP1_HUMAN
NC score	0.006024 (rank : 90)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	81	Target Neighborhood Hits	389	Shared Neighborhood Hits	6
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP3_HUMAN
NC score	0.005592 (rank : 91)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	81	Target Neighborhood Hits	250	Shared Neighborhood Hits	6
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP1_MOUSE
NC score	0.005337 (rank : 92)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	81	Target Neighborhood Hits	396	Shared Neighborhood Hits	6
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

WHRN_MOUSE
NC score	0.005038 (rank : 93)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	81	Target Neighborhood Hits	412	Shared Neighborhood Hits	9
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

TBX2_HUMAN
NC score	0.004110 (rank : 94)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	81	Target Neighborhood Hits	195	Shared Neighborhood Hits	3
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

DSG1C_MOUSE
NC score	0.003186 (rank : 95)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	81	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TSF0, Q7TQ61	Gene names	Dsg1c, Dsg6
Domain Architecture	No domain graphic available
Description	Desmoglein-1 gamma precursor (Dsg1-gamma) (Desmoglein-6).

SRGP2_HUMAN
NC score	0.001274 (rank : 96)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	81	Target Neighborhood Hits	331	Shared Neighborhood Hits	3
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ZN483_HUMAN
NC score	-0.001324 (rank : 97)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	81	Target Neighborhood Hits	785	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TF39	Gene names	ZNF483, KIAA1962
Domain Architecture
Description	Zinc finger protein 483.

ZBT40_HUMAN
NC score	-0.001752 (rank : 98)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	81	Target Neighborhood Hits	949	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

MAST4_HUMAN
NC score	-0.002488 (rank : 99)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	81	Target Neighborhood Hits	1804	Shared Neighborhood Hits	16
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).