Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : HIF1A_MOUSE

For an explanation of this page, click here

HIF1A_MOUSE
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HIF1A_HUMAN
θ value	0 (rank : 1)	NC score	0.993764 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	118	Shared Neighborhood Hits	51
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

EPAS1_MOUSE
θ value	2.04462e-161 (rank : 3)	NC score	0.977646 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

EPAS1_HUMAN
θ value	1.01473e-160 (rank : 4)	NC score	0.978948 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

SIM2_HUMAN
θ value	1.89707e-74 (rank : 5)	NC score	0.936152 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	7.20884e-74 (rank : 6)	NC score	0.935205 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	75	Shared Neighborhood Hits	37
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
θ value	4.67263e-73 (rank : 7)	NC score	0.933396 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	62	Shared Neighborhood Hits	38
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	1.7756e-72 (rank : 8)	NC score	0.932898 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NPAS3_MOUSE
θ value	8.00737e-57 (rank : 9)	NC score	0.907277 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	1.36585e-56 (rank : 10)	NC score	0.907626 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
θ value	1.91031e-50 (rank : 11)	NC score	0.908878 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	8.02596e-49 (rank : 12)	NC score	0.909256 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	34
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

BMAL1_HUMAN
θ value	1.0531e-32 (rank : 13)	NC score	0.825732 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	1.0531e-32 (rank : 14)	NC score	0.823646 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
θ value	1.57365e-28 (rank : 15)	NC score	0.802272 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

AHR_MOUSE
θ value	2.68423e-28 (rank : 16)	NC score	0.827578 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CLOCK_MOUSE
θ value	5.97985e-28 (rank : 17)	NC score	0.798932 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	148	Shared Neighborhood Hits	41
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

AHR_HUMAN
θ value	7.80994e-28 (rank : 18)	NC score	0.830453 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS2_MOUSE
θ value	1.12775e-26 (rank : 19)	NC score	0.788253 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

ARNT_HUMAN
θ value	1.47289e-26 (rank : 20)	NC score	0.776019 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.47289e-26 (rank : 21)	NC score	0.762959 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	213	Shared Neighborhood Hits	42
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_HUMAN
θ value	1.47289e-26 (rank : 22)	NC score	0.781677 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT2_HUMAN
θ value	7.30988e-26 (rank : 23)	NC score	0.781496 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	1.24688e-25 (rank : 24)	NC score	0.780485 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NPAS4_HUMAN
θ value	1.38178e-16 (rank : 25)	NC score	0.675124 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	214	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	2.88119e-14 (rank : 26)	NC score	0.657315 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	245	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA2_MOUSE
θ value	1.86753e-13 (rank : 27)	NC score	0.566264 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
θ value	1.2105e-12 (rank : 28)	NC score	0.565268 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA1_HUMAN
θ value	1.58096e-12 (rank : 29)	NC score	0.621006 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	2.69671e-12 (rank : 30)	NC score	0.623619 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	196	Shared Neighborhood Hits	41
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA3_HUMAN
θ value	6.64225e-11 (rank : 31)	NC score	0.566854 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	3.64472e-09 (rank : 32)	NC score	0.529454 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	203	Shared Neighborhood Hits	36
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
θ value	6.43352e-06 (rank : 33)	NC score	0.340095 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER1_HUMAN
θ value	1.43324e-05 (rank : 34)	NC score	0.315634 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	1.43324e-05 (rank : 35)	NC score	0.313470 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
θ value	0.00020696 (rank : 36)	NC score	0.302693 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	479	Shared Neighborhood Hits	39
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_HUMAN
θ value	0.00134147 (rank : 37)	NC score	0.309678 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	0.0113563 (rank : 38)	NC score	0.285995 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	325	Shared Neighborhood Hits	33
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

TRI37_HUMAN
θ value	0.0736092 (rank : 39)	NC score	0.020704 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	2
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

CJ078_HUMAN
θ value	0.125558 (rank : 40)	NC score	0.042691 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XK3, Q5JT40, Q8WW47	Gene names	C10orf78
Domain Architecture	No domain graphic available
Description	Protein C10orf78.

CSPG2_MOUSE
θ value	0.163984 (rank : 41)	NC score	0.010714 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	711	Shared Neighborhood Hits	6
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

MAGC1_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.036417 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MLL4_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.013946 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	722	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MUC7_HUMAN
θ value	0.62314 (rank : 44)	NC score	0.047137 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	538	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

RUFY2_HUMAN
θ value	0.62314 (rank : 45)	NC score	0.010194 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	1208	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RBNS5_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.022790 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

KI2L4_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.007682 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q99706, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q99559, Q99560, Q99561, Q99562, Q9UQJ7	Gene names	KIR2DL4, CD158D, KIR103AS
Domain Architecture
Description	Killer cell immunoglobulin-like receptor 2DL4 precursor (MHC class I NK cell receptor KIR103AS) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (G9P) (CD158d antigen).

SRRM2_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.031062 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	1296	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

STK10_MOUSE
θ value	1.81305 (rank : 49)	NC score	-0.001937 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	2132	Shared Neighborhood Hits	22
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SHE_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.008791 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	164	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SN1L2_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.000727 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	964	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SPAG5_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.006179 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	612	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

ICAL_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.012549 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	275	Shared Neighborhood Hits	9
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

NFAT5_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.012662 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

NSD1_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.009636 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	472	Shared Neighborhood Hits	14
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PKHA4_MOUSE
θ value	3.0926 (rank : 56)	NC score	0.009761 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

DDHD1_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.018310 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

GA2L2_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.008495 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

INT1_MOUSE
θ value	4.03905 (rank : 59)	NC score	0.014491 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

NED4L_MOUSE
θ value	4.03905 (rank : 60)	NC score	0.003334 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	231	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

UBP36_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.004629 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

PASK_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.002286 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	867	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCDAB_HUMAN
θ value	5.27518 (rank : 63)	NC score	-0.000380 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	211	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5I1, O75279	Gene names	PCDHA11
Domain Architecture
Description	Protocadherin alpha 11 precursor (PCDH-alpha11).

SELPL_MOUSE
θ value	5.27518 (rank : 64)	NC score	0.021188 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	588	Shared Neighborhood Hits	20
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

ZC3H3_MOUSE
θ value	5.27518 (rank : 65)	NC score	0.008825 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

K1377_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.011015 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2H0, Q4G0U6	Gene names	KIAA1377
Domain Architecture	No domain graphic available
Description	Protein KIAA1377.

MAP4_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.007077 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

SMOO_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.008785 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	391	Shared Neighborhood Hits	14
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SRRM2_MOUSE
θ value	6.88961 (rank : 69)	NC score	0.023932 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	1470	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TTBK1_HUMAN
θ value	6.88961 (rank : 70)	NC score	-0.000946 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	1058	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

UT14A_MOUSE
θ value	6.88961 (rank : 71)	NC score	0.005165 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	Q640M1, Q6A094, Q6EJB4, Q6P6L1, Q9CZK8	Gene names	Utp14a, JsdX, Kiaa0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog A (Juvenile spermatogonial depletion-like X-linked protein) (Jsd-like X-linked protein).

ZN406_HUMAN
θ value	6.88961 (rank : 72)	NC score	-0.003920 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	794	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).

AKTS1_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.008670 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

ASPP1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.003759 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	956	Shared Neighborhood Hits	15
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CHD3_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.001497 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	397	Shared Neighborhood Hits	8
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CJ078_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.022269 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	559	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

COHA1_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.004776 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	414	Shared Neighborhood Hits	9
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

EOMES_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.002068 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O95936, Q8TAZ2, Q9UPM7	Gene names	EOMES, TBR2
Domain Architecture
Description	Eomesodermin homolog.

GAK_HUMAN
θ value	8.99809 (rank : 79)	NC score	-0.002172 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	1028	Shared Neighborhood Hits	11
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GNDS_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.004300 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

HES1_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.028686 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.028742 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

IF39_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.005579 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

INT1_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.012080 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

KIF3A_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.001200 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	704	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3A_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.000690 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	715	Shared Neighborhood Hits	8
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

MLL2_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.018485 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	1788	Shared Neighborhood Hits	35
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RERE_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.010343 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	785	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TAGAP_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.003910 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TARA_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.021161 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	1626	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

HES5_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.062725 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.081825 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.085639 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.092252 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.090184 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MITF_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.072666 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.074353 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	15
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.065299 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.065290 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TCFL5_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.075700 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.074094 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.068560 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.068444 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.068005 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.067973 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.065608 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.060977 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

HIF1A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.993764 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	118	Shared Neighborhood Hits	51
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_HUMAN
NC score	0.978948 (rank : 3)	θ value	1.01473e-160 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.977646 (rank : 4)	θ value	2.04462e-161 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

SIM2_HUMAN
NC score	0.936152 (rank : 5)	θ value	1.89707e-74 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.935205 (rank : 6)	θ value	7.20884e-74 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	75	Shared Neighborhood Hits	37
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.933396 (rank : 7)	θ value	4.67263e-73 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	62	Shared Neighborhood Hits	38
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.932898 (rank : 8)	θ value	1.7756e-72 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NPAS1_MOUSE
NC score	0.909256 (rank : 9)	θ value	8.02596e-49 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	34
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.908878 (rank : 10)	θ value	1.91031e-50 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS3_HUMAN
NC score	0.907626 (rank : 11)	θ value	1.36585e-56 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.907277 (rank : 12)	θ value	8.00737e-57 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

AHR_HUMAN
NC score	0.830453 (rank : 13)	θ value	7.80994e-28 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.827578 (rank : 14)	θ value	2.68423e-28 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
NC score	0.825732 (rank : 15)	θ value	1.0531e-32 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.823646 (rank : 16)	θ value	1.0531e-32 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
NC score	0.802272 (rank : 17)	θ value	1.57365e-28 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.798932 (rank : 18)	θ value	5.97985e-28 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	148	Shared Neighborhood Hits	41
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_MOUSE
NC score	0.788253 (rank : 19)	θ value	1.12775e-26 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.781677 (rank : 20)	θ value	1.47289e-26 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT2_HUMAN
NC score	0.781496 (rank : 21)	θ value	7.30988e-26 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.780485 (rank : 22)	θ value	1.24688e-25 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.776019 (rank : 23)	θ value	1.47289e-26 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.762959 (rank : 24)	θ value	1.47289e-26 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	213	Shared Neighborhood Hits	42
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
NC score	0.675124 (rank : 25)	θ value	1.38178e-16 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	214	Shared Neighborhood Hits	43
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.657315 (rank : 26)	θ value	2.88119e-14 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	245	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.623619 (rank : 27)	θ value	2.69671e-12 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	196	Shared Neighborhood Hits	41
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.621006 (rank : 28)	θ value	1.58096e-12 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	198	Shared Neighborhood Hits	39
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.566854 (rank : 29)	θ value	6.64225e-11 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	171	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA2_MOUSE
NC score	0.566264 (rank : 30)	θ value	1.86753e-13 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.565268 (rank : 31)	θ value	1.2105e-12 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA3_MOUSE
NC score	0.529454 (rank : 32)	θ value	3.64472e-09 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	203	Shared Neighborhood Hits	36
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.340095 (rank : 33)	θ value	6.43352e-06 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER1_HUMAN
NC score	0.315634 (rank : 34)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.313470 (rank : 35)	θ value	1.43324e-05 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_HUMAN
NC score	0.309678 (rank : 36)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_HUMAN
NC score	0.302693 (rank : 37)	θ value	0.00020696 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	479	Shared Neighborhood Hits	39
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.285995 (rank : 38)	θ value	0.0113563 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	325	Shared Neighborhood Hits	33
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.092252 (rank : 39)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.090184 (rank : 40)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.085639 (rank : 41)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.081825 (rank : 42)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

TCFL5_HUMAN
NC score	0.075700 (rank : 43)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	90	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MITF_MOUSE
NC score	0.074353 (rank : 44)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	15
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.074094 (rank : 45)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_HUMAN
NC score	0.072666 (rank : 46)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
NC score	0.068560 (rank : 47)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	90	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.068444 (rank : 48)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	90	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
NC score	0.068005 (rank : 49)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	90	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.067973 (rank : 50)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.065608 (rank : 51)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	90	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MLX_HUMAN
NC score	0.065299 (rank : 52)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	90	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.065290 (rank : 53)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	90	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

HES5_MOUSE
NC score	0.062725 (rank : 54)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

USF2_MOUSE
NC score	0.060977 (rank : 55)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	90	Target Neighborhood Hits	173	Shared Neighborhood Hits	11
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MUC7_HUMAN
NC score	0.047137 (rank : 56)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	538	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

CJ078_HUMAN
NC score	0.042691 (rank : 57)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q86XK3, Q5JT40, Q8WW47	Gene names	C10orf78
Domain Architecture	No domain graphic available
Description	Protein C10orf78.

MAGC1_HUMAN
NC score	0.036417 (rank : 58)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	431	Shared Neighborhood Hits	22
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

SRRM2_HUMAN
NC score	0.031062 (rank : 59)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	1296	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

HES1_MOUSE
NC score	0.028742 (rank : 60)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	78	Shared Neighborhood Hits	8
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.028686 (rank : 61)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

SRRM2_MOUSE
NC score	0.023932 (rank : 62)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	1470	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

RBNS5_HUMAN
NC score	0.022790 (rank : 63)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	242	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

CJ078_MOUSE
NC score	0.022269 (rank : 64)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	559	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

SELPL_MOUSE
NC score	0.021188 (rank : 65)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	588	Shared Neighborhood Hits	20
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

TARA_HUMAN
NC score	0.021161 (rank : 66)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	1626	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TRI37_HUMAN
NC score	0.020704 (rank : 67)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	2
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

MLL2_HUMAN
NC score	0.018485 (rank : 68)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	1788	Shared Neighborhood Hits	35
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

DDHD1_HUMAN
NC score	0.018310 (rank : 69)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

INT1_MOUSE
NC score	0.014491 (rank : 70)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

MLL4_HUMAN
NC score	0.013946 (rank : 71)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	722	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NFAT5_HUMAN
NC score	0.012662 (rank : 72)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

ICAL_HUMAN
NC score	0.012549 (rank : 73)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	275	Shared Neighborhood Hits	9
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

INT1_HUMAN
NC score	0.012080 (rank : 74)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

K1377_HUMAN
NC score	0.011015 (rank : 75)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	166	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2H0, Q4G0U6	Gene names	KIAA1377
Domain Architecture	No domain graphic available
Description	Protein KIAA1377.

CSPG2_MOUSE
NC score	0.010714 (rank : 76)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	711	Shared Neighborhood Hits	6
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

RERE_MOUSE
NC score	0.010343 (rank : 77)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	785	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RUFY2_HUMAN
NC score	0.010194 (rank : 78)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	1208	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PKHA4_MOUSE
NC score	0.009761 (rank : 79)	θ value	3.0926 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

NSD1_MOUSE
NC score	0.009636 (rank : 80)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	472	Shared Neighborhood Hits	14
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

ZC3H3_MOUSE
NC score	0.008825 (rank : 81)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHP0, Q80X78	Gene names	Zc3h3, Kiaa0150, Zc3hdc3, Zfp623
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 3.

SHE_HUMAN
NC score	0.008791 (rank : 82)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	164	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SMOO_HUMAN
NC score	0.008785 (rank : 83)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	391	Shared Neighborhood Hits	14
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

AKTS1_HUMAN
NC score	0.008670 (rank : 84)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q96B36, Q96BI4, Q96IK7, Q96NG2, Q9BWR5	Gene names	AKT1S1, PRAS40
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate).

GA2L2_HUMAN
NC score	0.008495 (rank : 85)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NHY3, Q8NHY4	Gene names	GAS2L2, GAR17
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2) (GAS2-related protein on chromosome 17) (GAR17 protein).

KI2L4_HUMAN
NC score	0.007682 (rank : 86)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q99706, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q99559, Q99560, Q99561, Q99562, Q9UQJ7	Gene names	KIR2DL4, CD158D, KIR103AS
Domain Architecture
Description	Killer cell immunoglobulin-like receptor 2DL4 precursor (MHC class I NK cell receptor KIR103AS) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (G9P) (CD158d antigen).

MAP4_MOUSE
NC score	0.007077 (rank : 87)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	15
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

SPAG5_MOUSE
NC score	0.006179 (rank : 88)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	612	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

IF39_MOUSE
NC score	0.005579 (rank : 89)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

UT14A_MOUSE
NC score	0.005165 (rank : 90)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	Q640M1, Q6A094, Q6EJB4, Q6P6L1, Q9CZK8	Gene names	Utp14a, JsdX, Kiaa0266
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog A (Juvenile spermatogonial depletion-like X-linked protein) (Jsd-like X-linked protein).

COHA1_MOUSE
NC score	0.004776 (rank : 91)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	414	Shared Neighborhood Hits	9
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

UBP36_HUMAN
NC score	0.004629 (rank : 92)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	232	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

GNDS_HUMAN
NC score	0.004300 (rank : 93)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

TAGAP_MOUSE
NC score	0.003910 (rank : 94)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	83	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

ASPP1_HUMAN
NC score	0.003759 (rank : 95)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	956	Shared Neighborhood Hits	15
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

NED4L_MOUSE
NC score	0.003334 (rank : 96)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	231	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PASK_MOUSE
NC score	0.002286 (rank : 97)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	867	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

EOMES_HUMAN
NC score	0.002068 (rank : 98)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	O95936, Q8TAZ2, Q9UPM7	Gene names	EOMES, TBR2
Domain Architecture
Description	Eomesodermin homolog.

CHD3_HUMAN
NC score	0.001497 (rank : 99)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	397	Shared Neighborhood Hits	8
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

KIF3A_HUMAN
NC score	0.001200 (rank : 100)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	704	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

SN1L2_HUMAN
NC score	0.000727 (rank : 101)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	964	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

KIF3A_MOUSE
NC score	0.000690 (rank : 102)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	715	Shared Neighborhood Hits	8
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

PCDAB_HUMAN
NC score	-0.000380 (rank : 103)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	211	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5I1, O75279	Gene names	PCDHA11
Domain Architecture
Description	Protocadherin alpha 11 precursor (PCDH-alpha11).

TTBK1_HUMAN
NC score	-0.000946 (rank : 104)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	1058	Shared Neighborhood Hits	16
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

STK10_MOUSE
NC score	-0.001937 (rank : 105)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	2132	Shared Neighborhood Hits	22
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

GAK_HUMAN
NC score	-0.002172 (rank : 106)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	1028	Shared Neighborhood Hits	11
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ZN406_HUMAN
NC score	-0.003920 (rank : 107)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	794	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P243, Q3MIM5, Q6PJ01, Q75PJ7, Q75PJ9, Q86X64	Gene names	ZNF406, KIAA1485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 406 (Protein ZFAT).