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Network neighborhood for query Sequence : EPAS1_HUMAN

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EPAS1_HUMAN
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

EPAS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	0 (rank : 2)	NC score	0.994197 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	44
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
θ value	3.1544e-162 (rank : 3)	NC score	0.976450 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	1.01473e-160 (rank : 4)	NC score	0.978948 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM2_MOUSE
θ value	7.98882e-65 (rank : 5)	NC score	0.924058 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
θ value	8.83269e-64 (rank : 6)	NC score	0.922236 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	62	Shared Neighborhood Hits	38
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	9.76566e-63 (rank : 7)	NC score	0.921283 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	9.76566e-63 (rank : 8)	NC score	0.924438 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

NPAS3_HUMAN
θ value	3.974e-56 (rank : 9)	NC score	0.900651 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	6.77864e-56 (rank : 10)	NC score	0.900592 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
θ value	4.70527e-49 (rank : 11)	NC score	0.901675 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	34
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
θ value	2.3352e-48 (rank : 12)	NC score	0.900224 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

BMAL1_HUMAN
θ value	1.0531e-32 (rank : 13)	NC score	0.830571 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

CLOCK_HUMAN
θ value	1.37539e-32 (rank : 14)	NC score	0.811382 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

BMAL1_MOUSE
θ value	1.79631e-32 (rank : 15)	NC score	0.828226 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_MOUSE
θ value	1.16434e-31 (rank : 16)	NC score	0.807894 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_MOUSE
θ value	2.59387e-31 (rank : 17)	NC score	0.799120 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

ARNT2_MOUSE
θ value	9.8567e-31 (rank : 18)	NC score	0.793388 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
θ value	1.28732e-30 (rank : 19)	NC score	0.794169 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	3.74554e-30 (rank : 20)	NC score	0.788852 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_HUMAN
θ value	6.38894e-30 (rank : 21)	NC score	0.792996 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_MOUSE
θ value	1.08979e-29 (rank : 22)	NC score	0.774905 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	213	Shared Neighborhood Hits	39
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

AHR_MOUSE
θ value	1.99067e-23 (rank : 23)	NC score	0.812940 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_HUMAN
θ value	1.6852e-22 (rank : 24)	NC score	0.816161 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS4_HUMAN
θ value	3.63628e-17 (rank : 25)	NC score	0.673081 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	4.02038e-16 (rank : 26)	NC score	0.656582 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	245	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA2_MOUSE
θ value	7.09661e-13 (rank : 27)	NC score	0.563213 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
θ value	2.0648e-12 (rank : 28)	NC score	0.562488 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA3_HUMAN
θ value	2.28291e-11 (rank : 29)	NC score	0.566111 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA1_HUMAN
θ value	3.89403e-11 (rank : 30)	NC score	0.614588 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	8.67504e-11 (rank : 31)	NC score	0.617030 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	35
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA3_MOUSE
θ value	7.34386e-10 (rank : 32)	NC score	0.529781 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER1_MOUSE
θ value	6.43352e-06 (rank : 33)	NC score	0.322580 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	235	Shared Neighborhood Hits	29
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER1_HUMAN
θ value	8.40245e-06 (rank : 34)	NC score	0.325094 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER3_MOUSE
θ value	3.19293e-05 (rank : 35)	NC score	0.347110 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER3_HUMAN
θ value	0.00020696 (rank : 36)	NC score	0.309179 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	479	Shared Neighborhood Hits	40
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_HUMAN
θ value	0.00134147 (rank : 37)	NC score	0.317250 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	0.00390308 (rank : 38)	NC score	0.293878 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	325	Shared Neighborhood Hits	29
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

FANCJ_MOUSE
θ value	0.0330416 (rank : 39)	NC score	0.031788 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

ZDHC5_HUMAN
θ value	0.0563607 (rank : 40)	NC score	0.017624 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C0B5, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7	Gene names	ZDHHC5, KIAA1748, ZNF375
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375).

WASF2_MOUSE
θ value	0.279714 (rank : 41)	NC score	0.021813 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

PASK_HUMAN
θ value	0.365318 (rank : 42)	NC score	0.007607 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	857	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

UFO_MOUSE
θ value	0.365318 (rank : 43)	NC score	0.000282 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	988	Shared Neighborhood Hits	6
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

STK10_MOUSE
θ value	0.47712 (rank : 44)	NC score	-0.000662 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	2132	Shared Neighborhood Hits	15
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

NFAC4_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.012981 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

FOXC1_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.006205 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	218	Shared Neighborhood Hits	8
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

GBP1_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.008653 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

PASK_MOUSE
θ value	1.81305 (rank : 48)	NC score	0.005560 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	867	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

RAIN_MOUSE
θ value	1.81305 (rank : 49)	NC score	0.013593 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

MYCD_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.011391 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

MAGC1_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.032333 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

DPP9_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.006925 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q86TI2, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3	Gene names	DPP9, DPRP2
Domain Architecture	No domain graphic available
Description	Dipeptidyl peptidase 9 (EC 3.4.14.5) (Dipeptidyl peptidase IX) (DP9) (Dipeptidyl peptidase-like protein 9) (DPLP9) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2).

FBX42_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.009538 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3S6, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4	Gene names	FBXO42, FBX42, KIAA1332
Domain Architecture	No domain graphic available
Description	F-box only protein 42.

MUTYH_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.015617 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

PAX6_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.003236 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P26367, Q6N006, Q99413	Gene names	PAX6, AN2
Domain Architecture
Description	Paired box protein Pax-6 (Oculorhombin) (Aniridia type II protein).

PAX6_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.003236 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P63015, P32117, P70601, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8	Gene names	Pax6, Pax-6, Sey
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-6 (Oculorhombin).

SPG16_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.003005 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	377	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

WASF2_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.015760 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

ABRA_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.015731 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0Z2	Gene names	ABRA
Domain Architecture	No domain graphic available
Description	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS).

LPIN3_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.007396 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

RX_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.002768 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	423	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2V3	Gene names	RAX, RX
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

WRN_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.005263 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

BCL9_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.016478 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	770	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CBP_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.011911 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	941	Shared Neighborhood Hits	19
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.016209 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	1051	Shared Neighborhood Hits	20
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DOCK4_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.009445 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	237	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

KLF8_HUMAN
θ value	6.88961 (rank : 67)	NC score	-0.003793 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	704	Shared Neighborhood Hits	2
SwissProt Accessions	O95600, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4	Gene names	KLF8, BKLF3, ZNF741
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741).

MAGE1_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.010407 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	1389	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SLK_HUMAN
θ value	6.88961 (rank : 69)	NC score	-0.002824 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	1775	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SPTN2_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.000526 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	535	Shared Neighborhood Hits	4
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

DOCK4_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.007238 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

ESAM_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.003507 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	251	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PCGF6_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.004316 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

RHBD1_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.005484 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O75783, Q9NQ85	Gene names	RHBDL1, RHBDL
Domain Architecture
Description	Rhomboid-related protein 1 (EC 3.4.21.105) (RRP) (Rhomboid-like protein 1).

RTN4_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.005044 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SMCA2_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.002647 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	503	Shared Neighborhood Hits	10
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

HES5_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.061536 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.081031 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.084934 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.091860 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.089845 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MITF_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.075181 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	113	Shared Neighborhood Hits	13
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.077147 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.067531 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	95	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.067571 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCL1_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.050982 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

TCFL5_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.078977 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.077619 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.071834 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	11
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.071817 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.071060 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.071028 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.068232 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	155	Shared Neighborhood Hits	8
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.063441 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

EPAS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.994197 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	44
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_MOUSE
NC score	0.978948 (rank : 3)	θ value	1.01473e-160 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.976450 (rank : 4)	θ value	3.1544e-162 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

SIM2_HUMAN
NC score	0.924438 (rank : 5)	θ value	9.76566e-63 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.924058 (rank : 6)	θ value	7.98882e-65 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.922236 (rank : 7)	θ value	8.83269e-64 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	62	Shared Neighborhood Hits	38
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.921283 (rank : 8)	θ value	9.76566e-63 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NPAS1_MOUSE
NC score	0.901675 (rank : 9)	θ value	4.70527e-49 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	34
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
NC score	0.900651 (rank : 10)	θ value	3.974e-56 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.900592 (rank : 11)	θ value	6.77864e-56 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	103	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
NC score	0.900224 (rank : 12)	θ value	2.3352e-48 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

BMAL1_HUMAN
NC score	0.830571 (rank : 13)	θ value	1.0531e-32 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.828226 (rank : 14)	θ value	1.79631e-32 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

AHR_HUMAN
NC score	0.816161 (rank : 15)	θ value	1.6852e-22 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.812940 (rank : 16)	θ value	1.99067e-23 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CLOCK_HUMAN
NC score	0.811382 (rank : 17)	θ value	1.37539e-32 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.807894 (rank : 18)	θ value	1.16434e-31 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_MOUSE
NC score	0.799120 (rank : 19)	θ value	2.59387e-31 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

ARNT2_HUMAN
NC score	0.794169 (rank : 20)	θ value	1.28732e-30 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.793388 (rank : 21)	θ value	9.8567e-31 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NPAS2_HUMAN
NC score	0.792996 (rank : 22)	θ value	6.38894e-30 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_HUMAN
NC score	0.788852 (rank : 23)	θ value	3.74554e-30 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	38
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.774905 (rank : 24)	θ value	1.08979e-29 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	213	Shared Neighborhood Hits	39
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
NC score	0.673081 (rank : 25)	θ value	3.63628e-17 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.656582 (rank : 26)	θ value	4.02038e-16 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	245	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.617030 (rank : 27)	θ value	8.67504e-11 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	35
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.614588 (rank : 28)	θ value	3.89403e-11 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	198	Shared Neighborhood Hits	34
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.566111 (rank : 29)	θ value	2.28291e-11 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA2_MOUSE
NC score	0.563213 (rank : 30)	θ value	7.09661e-13 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.562488 (rank : 31)	θ value	2.0648e-12 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA3_MOUSE
NC score	0.529781 (rank : 32)	θ value	7.34386e-10 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.347110 (rank : 33)	θ value	3.19293e-05 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER1_HUMAN
NC score	0.325094 (rank : 34)	θ value	8.40245e-06 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	215	Shared Neighborhood Hits	32
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.322580 (rank : 35)	θ value	6.43352e-06 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	235	Shared Neighborhood Hits	29
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_HUMAN
NC score	0.317250 (rank : 36)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_HUMAN
NC score	0.309179 (rank : 37)	θ value	0.00020696 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	479	Shared Neighborhood Hits	40
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.293878 (rank : 38)	θ value	0.00390308 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	325	Shared Neighborhood Hits	29
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.091860 (rank : 39)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.089845 (rank : 40)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	80	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.084934 (rank : 41)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.081031 (rank : 42)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

TCFL5_HUMAN
NC score	0.078977 (rank : 43)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
NC score	0.077619 (rank : 44)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	10
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_MOUSE
NC score	0.077147 (rank : 45)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.075181 (rank : 46)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	113	Shared Neighborhood Hits	13
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
NC score	0.071834 (rank : 47)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	11
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.071817 (rank : 48)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
NC score	0.071060 (rank : 49)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.071028 (rank : 50)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	8
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.068232 (rank : 51)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	155	Shared Neighborhood Hits	8
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MLX_MOUSE
NC score	0.067571 (rank : 52)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.067531 (rank : 53)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	95	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF2_MOUSE
NC score	0.063441 (rank : 54)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	8
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

HES5_MOUSE
NC score	0.061536 (rank : 55)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MYCL1_MOUSE
NC score	0.050982 (rank : 56)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	123	Shared Neighborhood Hits	10
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MAGC1_HUMAN
NC score	0.032333 (rank : 57)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	17
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

FANCJ_MOUSE
NC score	0.031788 (rank : 58)	θ value	0.0330416 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

WASF2_MOUSE
NC score	0.021813 (rank : 59)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	315	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ZDHC5_HUMAN
NC score	0.017624 (rank : 60)	θ value	0.0563607 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9C0B5, Q6ZMF0, Q8TAK8, Q9H923, Q9UFI7	Gene names	ZDHHC5, KIAA1748, ZNF375
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375).

BCL9_MOUSE
NC score	0.016478 (rank : 61)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	770	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CBP_MOUSE
NC score	0.016209 (rank : 62)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	1051	Shared Neighborhood Hits	20
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

WASF2_HUMAN
NC score	0.015760 (rank : 63)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	280	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

ABRA_HUMAN
NC score	0.015731 (rank : 64)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N0Z2	Gene names	ABRA
Domain Architecture	No domain graphic available
Description	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS).

MUTYH_HUMAN
NC score	0.015617 (rank : 65)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UIF7, Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6	Gene names	MUTYH, MYH
Domain Architecture
Description	A/G-specific adenine DNA glycosylase (EC 3.2.2.-) (MutY homolog) (hMYH).

RAIN_MOUSE
NC score	0.013593 (rank : 66)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U0S6, Q6GQW4	Gene names	Rasip1
Domain Architecture	No domain graphic available
Description	Ras-interacting protein 1 (Rain).

NFAC4_HUMAN
NC score	0.012981 (rank : 67)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	165	Shared Neighborhood Hits	2
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

CBP_HUMAN
NC score	0.011911 (rank : 68)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	941	Shared Neighborhood Hits	19
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MYCD_MOUSE
NC score	0.011391 (rank : 69)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VIM5, Q8C3W6, Q8VIL4	Gene names	Myocd, Bsac2, Mycd, Srfcp
Domain Architecture
Description	Myocardin (SRF cofactor protein) (Basic SAP coiled-coil transcription activator 2).

MAGE1_HUMAN
NC score	0.010407 (rank : 70)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	1389	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

FBX42_HUMAN
NC score	0.009538 (rank : 71)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P3S6, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4	Gene names	FBXO42, FBX42, KIAA1332
Domain Architecture	No domain graphic available
Description	F-box only protein 42.

DOCK4_HUMAN
NC score	0.009445 (rank : 72)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	237	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

GBP1_MOUSE
NC score	0.008653 (rank : 73)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	302	Shared Neighborhood Hits	4
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

PASK_HUMAN
NC score	0.007607 (rank : 74)	θ value	0.365318 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	857	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

LPIN3_HUMAN
NC score	0.007396 (rank : 75)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

DOCK4_MOUSE
NC score	0.007238 (rank : 76)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DPP9_HUMAN
NC score	0.006925 (rank : 77)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q86TI2, Q6AI37, Q6UAL0, Q6ZMT2, Q6ZNJ5, Q8N2J7, Q8N3F5, Q8WXD8, Q96NT8, Q9BVR3	Gene names	DPP9, DPRP2
Domain Architecture	No domain graphic available
Description	Dipeptidyl peptidase 9 (EC 3.4.14.5) (Dipeptidyl peptidase IX) (DP9) (Dipeptidyl peptidase-like protein 9) (DPLP9) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2).

FOXC1_MOUSE
NC score	0.006205 (rank : 78)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	218	Shared Neighborhood Hits	8
SwissProt Accessions	Q61572, O88409, Q61582	Gene names	Foxc1, Fkh1, Fkhl7, Freac3, Mf1
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3) (Transcription factor FKH-1) (Mesoderm/mesenchyme forkhead 1) (MF-1).

PASK_MOUSE
NC score	0.005560 (rank : 79)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	867	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

RHBD1_HUMAN
NC score	0.005484 (rank : 80)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	O75783, Q9NQ85	Gene names	RHBDL1, RHBDL
Domain Architecture
Description	Rhomboid-related protein 1 (EC 3.4.21.105) (RRP) (Rhomboid-like protein 1).

WRN_MOUSE
NC score	0.005263 (rank : 81)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RTN4_MOUSE
NC score	0.005044 (rank : 82)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	341	Shared Neighborhood Hits	7
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

PCGF6_HUMAN
NC score	0.004316 (rank : 83)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	178	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYE7, Q5SYD1, Q5SYD6, Q96ID9, Q96SJ1	Gene names	PCGF6, MBLR, RNF134
Domain Architecture	No domain graphic available
Description	Polycomb group RING finger protein 6 (RING finger protein 134) (Mel18 and Bmi1-like RING finger).

ESAM_HUMAN
NC score	0.003507 (rank : 84)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	251	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PAX6_HUMAN
NC score	0.003236 (rank : 85)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P26367, Q6N006, Q99413	Gene names	PAX6, AN2
Domain Architecture
Description	Paired box protein Pax-6 (Oculorhombin) (Aniridia type II protein).

PAX6_MOUSE
NC score	0.003236 (rank : 86)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	383	Shared Neighborhood Hits	4
SwissProt Accessions	P63015, P32117, P70601, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8	Gene names	Pax6, Pax-6, Sey
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-6 (Oculorhombin).

SPG16_MOUSE
NC score	0.003005 (rank : 87)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	377	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K450, Q8C450, Q9CPU8, Q9D522	Gene names	Spag16, Pf20
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 16 protein (PF20 protein homolog).

RX_HUMAN
NC score	0.002768 (rank : 88)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	423	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2V3	Gene names	RAX, RX
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

SMCA2_HUMAN
NC score	0.002647 (rank : 89)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	503	Shared Neighborhood Hits	10
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SPTN2_HUMAN
NC score	0.000526 (rank : 90)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	535	Shared Neighborhood Hits	4
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

UFO_MOUSE
NC score	0.000282 (rank : 91)	θ value	0.365318 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	988	Shared Neighborhood Hits	6
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

STK10_MOUSE
NC score	-0.000662 (rank : 92)	θ value	0.47712 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	2132	Shared Neighborhood Hits	15
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SLK_HUMAN
NC score	-0.002824 (rank : 93)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	1775	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KLF8_HUMAN
NC score	-0.003793 (rank : 94)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	704	Shared Neighborhood Hits	2
SwissProt Accessions	O95600, Q59GV5, Q5HYQ5, Q5JXP7, Q6MZJ7, Q9UGC4	Gene names	KLF8, BKLF3, ZNF741
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 8 (Basic krueppel-like factor 3) (Zinc finger protein 741).