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Network neighborhood for query Sequence : MITF_MOUSE

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MITF_MOUSE
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MITF_HUMAN
θ value	0 (rank : 1)	NC score	0.996538 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
θ value	4.95767e-99 (rank : 3)	NC score	0.941851 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	190	Shared Neighborhood Hits	74
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	5.15425e-80 (rank : 4)	NC score	0.939542 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	2.82823e-78 (rank : 5)	NC score	0.940326 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF2_HUMAN
θ value	4.0297e-08 (rank : 6)	NC score	0.513430 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	155	Shared Neighborhood Hits	57
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF1_HUMAN
θ value	1.53129e-07 (rank : 7)	NC score	0.496924 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	1.53129e-07 (rank : 8)	NC score	0.497772 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
θ value	1.53129e-07 (rank : 9)	NC score	0.507817 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	57
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

SRBP1_MOUSE
θ value	9.92553e-07 (rank : 10)	NC score	0.378322 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	384	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_HUMAN
θ value	1.29631e-06 (rank : 11)	NC score	0.391825 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	2.88788e-06 (rank : 12)	NC score	0.407274 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	55
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

ARNT_HUMAN
θ value	0.000602161 (rank : 13)	NC score	0.261769 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0.000602161 (rank : 14)	NC score	0.257365 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_MOUSE
θ value	0.000602161 (rank : 15)	NC score	0.227693 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

RNC_HUMAN
θ value	0.000602161 (rank : 16)	NC score	0.136770 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	176	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

CLOCK_HUMAN
θ value	0.00102713 (rank : 17)	NC score	0.224181 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MYCN_HUMAN
θ value	0.00102713 (rank : 18)	NC score	0.286236 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MAD4_HUMAN
θ value	0.00298849 (rank : 19)	NC score	0.294963 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

BMAL1_HUMAN
θ value	0.00390308 (rank : 20)	NC score	0.238086 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	52
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.00390308 (rank : 21)	NC score	0.237589 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	121	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MYCN_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.273746 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

ARNT2_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.233568 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0.0113563 (rank : 24)	NC score	0.233970 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

HES1_HUMAN
θ value	0.0113563 (rank : 25)	NC score	0.228073 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.0113563 (rank : 26)	NC score	0.228803 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MYCS_MOUSE
θ value	0.0113563 (rank : 27)	NC score	0.261816 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

TFAP4_HUMAN
θ value	0.0113563 (rank : 28)	NC score	0.250696 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	289	Shared Neighborhood Hits	48
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MYC_HUMAN
θ value	0.0330416 (rank : 29)	NC score	0.258151 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

HEY1_MOUSE
θ value	0.0431538 (rank : 30)	NC score	0.260896 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	0.0563607 (rank : 31)	NC score	0.269187 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	0.0563607 (rank : 32)	NC score	0.267196 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAD3_HUMAN
θ value	0.0563607 (rank : 33)	NC score	0.246156 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAX_MOUSE
θ value	0.0563607 (rank : 34)	NC score	0.344962 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	52
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MNT_HUMAN
θ value	0.0563607 (rank : 35)	NC score	0.210239 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	496	Shared Neighborhood Hits	49
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HES4_HUMAN
θ value	0.0736092 (rank : 36)	NC score	0.209548 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MAX_HUMAN
θ value	0.0736092 (rank : 37)	NC score	0.346988 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

WBS14_HUMAN
θ value	0.0736092 (rank : 38)	NC score	0.165994 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	273	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HEY1_HUMAN
θ value	0.0961366 (rank : 39)	NC score	0.249693 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	82	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MYCL2_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.193340 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

WBS14_MOUSE
θ value	0.0961366 (rank : 41)	NC score	0.149946 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

MNT_MOUSE
θ value	0.125558 (rank : 42)	NC score	0.215684 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	432	Shared Neighborhood Hits	47
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MXI1_HUMAN
θ value	0.125558 (rank : 43)	NC score	0.233328 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	0.125558 (rank : 44)	NC score	0.233535 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYC_MOUSE
θ value	0.125558 (rank : 45)	NC score	0.246798 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SMC1A_MOUSE
θ value	0.125558 (rank : 46)	NC score	0.029253 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	1384	Shared Neighborhood Hits	18
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

TSK_HUMAN
θ value	0.163984 (rank : 47)	NC score	0.027961 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

MAD3_MOUSE
θ value	0.279714 (rank : 48)	NC score	0.225053 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

NPAS2_HUMAN
θ value	0.279714 (rank : 49)	NC score	0.171370 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.279714 (rank : 50)	NC score	0.171355 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	39
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

MLX_MOUSE
θ value	0.365318 (rank : 51)	NC score	0.274097 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	49
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

FLIP1_HUMAN
θ value	0.47712 (rank : 52)	NC score	0.028550 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	1405	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CNTRB_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.032653 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	1029	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

MLX_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.242450 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

NCOA1_HUMAN
θ value	0.62314 (rank : 55)	NC score	0.101177 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	0.62314 (rank : 56)	NC score	0.101094 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	196	Shared Neighborhood Hits	32
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

MYH9_HUMAN
θ value	0.813845 (rank : 57)	NC score	0.020591 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	1762	Shared Neighborhood Hits	36
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

TAL1_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.080745 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	112	Shared Neighborhood Hits	29
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	0.813845 (rank : 59)	NC score	0.079120 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	110	Shared Neighborhood Hits	29
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

FYCO1_MOUSE
θ value	1.38821 (rank : 60)	NC score	0.016509 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	1059	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

MYCL1_HUMAN
θ value	1.38821 (rank : 61)	NC score	0.218608 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	51
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	1.38821 (rank : 62)	NC score	0.215315 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	123	Shared Neighborhood Hits	47
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SYCP1_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.017652 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	1313	Shared Neighborhood Hits	20
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

MAD1_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.148430 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	35
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

PRPF3_MOUSE
θ value	1.81305 (rank : 65)	NC score	0.048825 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

XE7_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.058479 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	738	Shared Neighborhood Hits	26
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

BPTF_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.017368 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	786	Shared Neighborhood Hits	16
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

LYL1_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.047301 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	21
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

MAD1_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.152725 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	37
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYH9_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.016891 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	1829	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PTN23_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.009904 (rank : 133)
Query Neighborhood Hits	115	Target Neighborhood Hits	646	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

RECQ4_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.013807 (rank : 129)
Query Neighborhood Hits	115	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

SVIL_MOUSE
θ value	2.36792 (rank : 73)	NC score	0.017374 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

ASCL2_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.051480 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

BHLH2_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.137081 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	51
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_HUMAN
θ value	3.0926 (rank : 76)	NC score	0.161648 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

FLIP1_MOUSE
θ value	3.0926 (rank : 77)	NC score	0.025398 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	1176	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PRPF3_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.044805 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

TSK_MOUSE
θ value	3.0926 (rank : 79)	NC score	0.015024 (rank : 126)
Query Neighborhood Hits	115	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

BHLH2_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.124687 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_MOUSE
θ value	4.03905 (rank : 81)	NC score	0.157469 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

CRTC1_MOUSE
θ value	4.03905 (rank : 82)	NC score	0.021873 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	230	Shared Neighborhood Hits	6
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

DLG7_MOUSE
θ value	4.03905 (rank : 83)	NC score	0.035241 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K4R9, Q6ZQL3, Q80VS7, Q8BUC8, Q8BZ79	Gene names	Dlg7, Kiaa0008
Domain Architecture	No domain graphic available
Description	Discs large homolog 7 (Hepatoma up-regulated protein homolog) (HURP).

HES7_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.106353 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	4.03905 (rank : 85)	NC score	0.103756 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

ITF2_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.045484 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.040009 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

STK36_HUMAN
θ value	4.03905 (rank : 88)	NC score	-0.002919 (rank : 142)
Query Neighborhood Hits	115	Target Neighborhood Hits	896	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TFE2_HUMAN
θ value	4.03905 (rank : 89)	NC score	0.041769 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

DESP_HUMAN
θ value	5.27518 (rank : 90)	NC score	0.016113 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

NHS_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.019545 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

REST_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.014987 (rank : 127)
Query Neighborhood Hits	115	Target Neighborhood Hits	1506	Shared Neighborhood Hits	22
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SON_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.026558 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	1568	Shared Neighborhood Hits	34
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GGA1_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.008301 (rank : 138)
Query Neighborhood Hits	115	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

IF3A_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.019239 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	875	Shared Neighborhood Hits	21
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

MKL1_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.012605 (rank : 130)
Query Neighborhood Hits	115	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

PDE4A_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.004082 (rank : 140)
Query Neighborhood Hits	115	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

SEPP1_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.014886 (rank : 128)
Query Neighborhood Hits	115	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9	Gene names	SEPP1, SELP
Domain Architecture
Description	Selenoprotein P precursor (SeP).

SMC1A_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.019724 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	1346	Shared Neighborhood Hits	18
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SSPO_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.001327 (rank : 141)
Query Neighborhood Hits	115	Target Neighborhood Hits	800	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

TLE1_HUMAN
θ value	6.88961 (rank : 101)	NC score	0.009142 (rank : 135)
Query Neighborhood Hits	115	Target Neighborhood Hits	485	Shared Neighborhood Hits	8
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
θ value	6.88961 (rank : 102)	NC score	0.009099 (rank : 136)
Query Neighborhood Hits	115	Target Neighborhood Hits	491	Shared Neighborhood Hits	7
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

YTDC1_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.010990 (rank : 131)
Query Neighborhood Hits	115	Target Neighborhood Hits	458	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZEP1_HUMAN
θ value	6.88961 (rank : 104)	NC score	0.004803 (rank : 139)
Query Neighborhood Hits	115	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

AHR_HUMAN
θ value	8.99809 (rank : 105)	NC score	0.080130 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CCD39_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.022335 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	868	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

HES6_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.104901 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

ITSN2_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.008332 (rank : 137)
Query Neighborhood Hits	115	Target Neighborhood Hits	1173	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MADCA_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.010733 (rank : 132)
Query Neighborhood Hits	115	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MYF6_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.044777 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	74	Shared Neighborhood Hits	25
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.042011 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

PESC_MOUSE
θ value	8.99809 (rank : 112)	NC score	0.015957 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQ61, Q542F0	Gene names	Pes1
Domain Architecture
Description	Pescadillo homolog 1.

TCFL5_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.155810 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE2_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.032153 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

TMM24_MOUSE
θ value	8.99809 (rank : 115)	NC score	0.009889 (rank : 134)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80X80	Gene names	Tmem24
Domain Architecture	No domain graphic available
Description	Transmembrane protein 24.

AHR_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.068771 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BHLH8_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.050406 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

EPAS1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.077147 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.076552 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HES2_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.079457 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.083624 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.074424 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.099599 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.102111 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HIF1A_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.075304 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	15
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.074353 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

MAD4_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.134485 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYCB_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.082144 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

NCOA2_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.059262 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.060179 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.067541 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.061399 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.062227 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.059224 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.063754 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.065119 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PER2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.056771 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.051182 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

SIM1_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.069878 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.070005 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.070716 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.070131 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

Hits sorted by NC score

MITF_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.996538 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.941851 (rank : 3)	θ value	4.95767e-99 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	190	Shared Neighborhood Hits	74
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_MOUSE
NC score	0.940326 (rank : 4)	θ value	2.82823e-78 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.939542 (rank : 5)	θ value	5.15425e-80 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

USF2_HUMAN
NC score	0.513430 (rank : 6)	θ value	4.0297e-08 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	155	Shared Neighborhood Hits	57
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.507817 (rank : 7)	θ value	1.53129e-07 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	57
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF1_MOUSE
NC score	0.497772 (rank : 8)	θ value	1.53129e-07 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.496924 (rank : 9)	θ value	1.53129e-07 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

SRBP2_HUMAN
NC score	0.407274 (rank : 10)	θ value	2.88788e-06 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	55
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
NC score	0.391825 (rank : 11)	θ value	1.29631e-06 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	225	Shared Neighborhood Hits	58
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.378322 (rank : 12)	θ value	9.92553e-07 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	384	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAX_HUMAN
NC score	0.346988 (rank : 13)	θ value	0.0736092 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
NC score	0.344962 (rank : 14)	θ value	0.0563607 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	52
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAD4_HUMAN
NC score	0.294963 (rank : 15)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYCN_HUMAN
NC score	0.286236 (rank : 16)	θ value	0.00102713 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MLX_MOUSE
NC score	0.274097 (rank : 17)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	49
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCN_MOUSE
NC score	0.273746 (rank : 18)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

HEY2_HUMAN
NC score	0.269187 (rank : 19)	θ value	0.0563607 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.267196 (rank : 20)	θ value	0.0563607 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MYCS_MOUSE
NC score	0.261816 (rank : 21)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

ARNT_HUMAN
NC score	0.261769 (rank : 22)	θ value	0.000602161 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	53
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

HEY1_MOUSE
NC score	0.260896 (rank : 23)	θ value	0.0431538 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MYC_HUMAN
NC score	0.258151 (rank : 24)	θ value	0.0330416 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

ARNT_MOUSE
NC score	0.257365 (rank : 25)	θ value	0.000602161 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

TFAP4_HUMAN
NC score	0.250696 (rank : 26)	θ value	0.0113563 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	289	Shared Neighborhood Hits	48
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

HEY1_HUMAN
NC score	0.249693 (rank : 27)	θ value	0.0961366 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	82	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MYC_MOUSE
NC score	0.246798 (rank : 28)	θ value	0.125558 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAD3_HUMAN
NC score	0.246156 (rank : 29)	θ value	0.0563607 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	40
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MLX_HUMAN
NC score	0.242450 (rank : 30)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

BMAL1_HUMAN
NC score	0.238086 (rank : 31)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	52
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.237589 (rank : 32)	θ value	0.00390308 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	121	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT2_MOUSE
NC score	0.233970 (rank : 33)	θ value	0.0113563 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.233568 (rank : 34)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	49
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MXI1_MOUSE
NC score	0.233535 (rank : 35)	θ value	0.125558 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
NC score	0.233328 (rank : 36)	θ value	0.125558 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

HES1_MOUSE
NC score	0.228803 (rank : 37)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.228073 (rank : 38)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

CLOCK_MOUSE
NC score	0.227693 (rank : 39)	θ value	0.000602161 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD3_MOUSE
NC score	0.225053 (rank : 40)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

CLOCK_HUMAN
NC score	0.224181 (rank : 41)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MYCL1_HUMAN
NC score	0.218608 (rank : 42)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	51
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MNT_MOUSE
NC score	0.215684 (rank : 43)	θ value	0.125558 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	432	Shared Neighborhood Hits	47
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCL1_MOUSE
NC score	0.215315 (rank : 44)	θ value	1.38821 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	123	Shared Neighborhood Hits	47
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MNT_HUMAN
NC score	0.210239 (rank : 45)	θ value	0.0563607 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	496	Shared Neighborhood Hits	49
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HES4_HUMAN
NC score	0.209548 (rank : 46)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MYCL2_HUMAN
NC score	0.193340 (rank : 47)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

NPAS2_HUMAN
NC score	0.171370 (rank : 48)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	38
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.171355 (rank : 49)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	39
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

WBS14_HUMAN
NC score	0.165994 (rank : 50)	θ value	0.0736092 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	273	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

BHLH3_HUMAN
NC score	0.161648 (rank : 51)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.157469 (rank : 52)	θ value	4.03905 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

TCFL5_HUMAN
NC score	0.155810 (rank : 53)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MAD1_MOUSE
NC score	0.152725 (rank : 54)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	37
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

WBS14_MOUSE
NC score	0.149946 (rank : 55)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

MAD1_HUMAN
NC score	0.148430 (rank : 56)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	35
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

BHLH2_HUMAN
NC score	0.137081 (rank : 57)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	51
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

RNC_HUMAN
NC score	0.136770 (rank : 58)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	176	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

MAD4_MOUSE
NC score	0.134485 (rank : 59)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

BHLH2_MOUSE
NC score	0.124687 (rank : 60)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES7_HUMAN
NC score	0.106353 (rank : 61)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES6_MOUSE
NC score	0.104901 (rank : 62)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_MOUSE
NC score	0.103756 (rank : 63)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES6_HUMAN
NC score	0.102111 (rank : 64)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

NCOA1_HUMAN
NC score	0.101177 (rank : 65)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	31
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
NC score	0.101094 (rank : 66)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	196	Shared Neighborhood Hits	32
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

HES5_MOUSE
NC score	0.099599 (rank : 67)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES2_MOUSE
NC score	0.083624 (rank : 68)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MYCB_MOUSE
NC score	0.082144 (rank : 69)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	115	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

TAL1_HUMAN
NC score	0.080745 (rank : 70)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	112	Shared Neighborhood Hits	29
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

AHR_HUMAN
NC score	0.080130 (rank : 71)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

HES2_HUMAN
NC score	0.079457 (rank : 72)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

TAL1_MOUSE
NC score	0.079120 (rank : 73)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	110	Shared Neighborhood Hits	29
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

EPAS1_HUMAN
NC score	0.077147 (rank : 74)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.076552 (rank : 75)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
NC score	0.075304 (rank : 76)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	15
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HES3_MOUSE
NC score	0.074424 (rank : 77)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HIF1A_MOUSE
NC score	0.074353 (rank : 78)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	15
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM2_HUMAN
NC score	0.070716 (rank : 79)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.070131 (rank : 80)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_MOUSE
NC score	0.070005 (rank : 81)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.069878 (rank : 82)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	115	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

AHR_MOUSE
NC score	0.068771 (rank : 83)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	55	Shared Neighborhood Hits	13
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA3_HUMAN
NC score	0.067541 (rank : 84)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NPAS3_MOUSE
NC score	0.065119 (rank : 85)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.063754 (rank : 86)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
NC score	0.062227 (rank : 87)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	15
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NCOA3_MOUSE
NC score	0.061399 (rank : 88)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NCOA2_MOUSE
NC score	0.060179 (rank : 89)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	17
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.059262 (rank : 90)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	15
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS1_MOUSE
NC score	0.059224 (rank : 91)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	16
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

XE7_HUMAN
NC score	0.058479 (rank : 92)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	738	Shared Neighborhood Hits	26
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

PER2_MOUSE
NC score	0.056771 (rank : 93)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	115	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

ASCL2_MOUSE
NC score	0.051480 (rank : 94)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

PER3_MOUSE
NC score	0.051182 (rank : 95)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	115	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

BHLH8_MOUSE
NC score	0.050406 (rank : 96)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

PRPF3_MOUSE
NC score	0.048825 (rank : 97)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q922U1, Q3TJH4, Q9D6C6	Gene names	Prpf3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3).

LYL1_HUMAN
NC score	0.047301 (rank : 98)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	21
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

ITF2_HUMAN
NC score	0.045484 (rank : 99)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	168	Shared Neighborhood Hits	16
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

PRPF3_HUMAN
NC score	0.044805 (rank : 100)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	O43395, O43446	Gene names	PRPF3, HPRP3, PRP3
Domain Architecture
Description	U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (U4/U6 snRNP 90 kDa protein) (hPrp3).

MYF6_HUMAN
NC score	0.044777 (rank : 101)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	74	Shared Neighborhood Hits	25
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
NC score	0.042011 (rank : 102)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

TFE2_HUMAN
NC score	0.041769 (rank : 103)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	161	Shared Neighborhood Hits	15
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

ITF2_MOUSE
NC score	0.040009 (rank : 104)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	16
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

DLG7_MOUSE
NC score	0.035241 (rank : 105)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	84	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K4R9, Q6ZQL3, Q80VS7, Q8BUC8, Q8BZ79	Gene names	Dlg7, Kiaa0008
Domain Architecture	No domain graphic available
Description	Discs large homolog 7 (Hepatoma up-regulated protein homolog) (HURP).

CNTRB_MOUSE
NC score	0.032653 (rank : 106)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	1029	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

TFE2_MOUSE
NC score	0.032153 (rank : 107)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

SMC1A_MOUSE
NC score	0.029253 (rank : 108)	θ value	0.125558 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	1384	Shared Neighborhood Hits	18
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

FLIP1_HUMAN
NC score	0.028550 (rank : 109)	θ value	0.47712 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	1405	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

TSK_HUMAN
NC score	0.027961 (rank : 110)	θ value	0.163984 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WUA8, Q6UXK1, Q9UG10, Q9UJX9	Gene names	LRRC54, E2IG4, TSK
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54) (E2- induced gene 4 protein).

SON_HUMAN
NC score	0.026558 (rank : 111)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	1568	Shared Neighborhood Hits	34
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

FLIP1_MOUSE
NC score	0.025398 (rank : 112)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	1176	Shared Neighborhood Hits	21
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CCD39_HUMAN
NC score	0.022335 (rank : 113)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	868	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CRTC1_MOUSE
NC score	0.021873 (rank : 114)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	230	Shared Neighborhood Hits	6
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

MYH9_HUMAN
NC score	0.020591 (rank : 115)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	1762	Shared Neighborhood Hits	36
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SMC1A_HUMAN
NC score	0.019724 (rank : 116)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	1346	Shared Neighborhood Hits	18
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

NHS_HUMAN
NC score	0.019545 (rank : 117)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	6
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

IF3A_HUMAN
NC score	0.019239 (rank : 118)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	875	Shared Neighborhood Hits	21
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

SYCP1_HUMAN
NC score	0.017652 (rank : 119)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	1313	Shared Neighborhood Hits	20
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SVIL_MOUSE
NC score	0.017374 (rank : 120)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	439	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

BPTF_HUMAN
NC score	0.017368 (rank : 121)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	786	Shared Neighborhood Hits	16
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

MYH9_MOUSE
NC score	0.016891 (rank : 122)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	1829	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

FYCO1_MOUSE
NC score	0.016509 (rank : 123)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	1059	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

DESP_HUMAN
NC score	0.016113 (rank : 124)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	1470	Shared Neighborhood Hits	26
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

PESC_MOUSE
NC score	0.015957 (rank : 125)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQ61, Q542F0	Gene names	Pes1
Domain Architecture
Description	Pescadillo homolog 1.

TSK_MOUSE
NC score	0.015024 (rank : 126)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	271	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBR6, Q4W655	Gene names	Lrrc54, Tsk
Domain Architecture	No domain graphic available
Description	Tsukushi precursor (Leucine-rich repeat-containing protein 54).

REST_MOUSE
NC score	0.014987 (rank : 127)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	1506	Shared Neighborhood Hits	22
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SEPP1_HUMAN
NC score	0.014886 (rank : 128)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P49908, Q6PD59, Q6PI43, Q6PI87, Q6PJF9	Gene names	SEPP1, SELP
Domain Architecture
Description	Selenoprotein P precursor (SeP).

RECQ4_MOUSE
NC score	0.013807 (rank : 129)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

MKL1_HUMAN
NC score	0.012605 (rank : 130)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	232	Shared Neighborhood Hits	8
SwissProt Accessions	Q969V6, Q8TCL1, Q96SC5, Q96SC6, Q9P2B0	Gene names	MKL1, KIAA1438, MAL
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein).

YTDC1_HUMAN
NC score	0.010990 (rank : 131)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	458	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

MADCA_HUMAN
NC score	0.010733 (rank : 132)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	221	Shared Neighborhood Hits	4
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

PTN23_HUMAN
NC score	0.009904 (rank : 133)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	646	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

TMM24_MOUSE
NC score	0.009889 (rank : 134)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q80X80	Gene names	Tmem24
Domain Architecture	No domain graphic available
Description	Transmembrane protein 24.

TLE1_HUMAN
NC score	0.009142 (rank : 135)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	485	Shared Neighborhood Hits	8
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE1_MOUSE
NC score	0.009099 (rank : 136)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	491	Shared Neighborhood Hits	7
SwissProt Accessions	Q62440	Gene names	Tle1, Grg1
Domain Architecture
Description	Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg- 1).

ITSN2_HUMAN
NC score	0.008332 (rank : 137)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	1173	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

GGA1_MOUSE
NC score	0.008301 (rank : 138)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	128	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

ZEP1_HUMAN
NC score	0.004803 (rank : 139)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	1036	Shared Neighborhood Hits	12
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

PDE4A_MOUSE
NC score	0.004082 (rank : 140)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

SSPO_MOUSE
NC score	0.001327 (rank : 141)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	800	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

STK36_HUMAN
NC score	-0.002919 (rank : 142)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	896	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).