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Network neighborhood for query Sequence : INT1_HUMAN

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INT1_HUMAN
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

INT1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

INT1_MOUSE
θ value	0 (rank : 2)	NC score	0.982007 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	44	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

NFH_MOUSE
θ value	0.125558 (rank : 3)	NC score	0.021417 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	2247	Shared Neighborhood Hits	19
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

OLIG2_HUMAN
θ value	0.47712 (rank : 4)	NC score	0.032474 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

REEP1_HUMAN
θ value	0.47712 (rank : 5)	NC score	0.048919 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H902, Q53TI0	Gene names	REEP1, C2orf23
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 1.

SOX12_MOUSE
θ value	0.813845 (rank : 6)	NC score	0.020635 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

TF3B_MOUSE
θ value	0.813845 (rank : 7)	NC score	0.056795 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

CEND3_MOUSE
θ value	1.06291 (rank : 8)	NC score	0.017603 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	228	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

SYWM_MOUSE
θ value	1.38821 (rank : 9)	NC score	0.039863 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYK1	Gene names	Wars2
Domain Architecture
Description	Tryptophanyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) ((Mt)TrpRS).

CSF3_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.043496 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P09920	Gene names	Csf3, Csfg
Domain Architecture
Description	Granulocyte colony-stimulating factor precursor (G-CSF).

GROA_MOUSE
θ value	2.36792 (rank : 11)	NC score	0.024943 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P12850	Gene names	Cxcl1, Gro, Gro1, Mgsa, Scyb1
Domain Architecture
Description	Growth-regulated alpha protein precursor (CXCL1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Contains: KC(5-72) (KC-T) (Hematopoietic synergistic factor) (HSF)].

MYH10_HUMAN
θ value	2.36792 (rank : 12)	NC score	0.008947 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	1620	Shared Neighborhood Hits	11
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	3.0926 (rank : 13)	NC score	0.008672 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	1612	Shared Neighborhood Hits	11
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PRGR_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.010067 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

RAD50_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.016192 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	1366	Shared Neighborhood Hits	12
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

REC8L_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.043644 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

RSU1_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.018697 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	239	Shared Neighborhood Hits	4
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

CTF1_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.029921 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q60753	Gene names	Ctf1
Domain Architecture	No domain graphic available
Description	Cardiotrophin-1 (CT-1).

GSTA5_HUMAN
θ value	4.03905 (rank : 19)	NC score	0.013067 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q7RTV2	Gene names	GSTA5
Domain Architecture	No domain graphic available
Description	Glutathione S-transferase A5 (EC 2.5.1.18) (Glutathione S-transferase A5-5) (GST class-alpha member 5).

MARK3_MOUSE
θ value	4.03905 (rank : 20)	NC score	0.001682 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	919	Shared Neighborhood Hits	4
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

PI4KA_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.025255 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

RAD50_HUMAN
θ value	4.03905 (rank : 22)	NC score	0.015860 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	1317	Shared Neighborhood Hits	11
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RBL1_MOUSE
θ value	4.03905 (rank : 23)	NC score	0.015794 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q64701	Gene names	Rbl1
Domain Architecture
Description	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107).

RSU1_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.016451 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

SOX12_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.014714 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	O15370, Q9NUD4	Gene names	SOX12, SOX22
Domain Architecture
Description	SOX-12 protein (SOX-22 protein).

TECT3_HUMAN
θ value	4.03905 (rank : 26)	NC score	0.032193 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NUS6, Q6P7P3, Q6UW27, Q6ZQQ0, Q8N7K1, Q8NBQ0, Q96GF7, Q9Y3U1	Gene names	TECT3, C10orf61
Domain Architecture	No domain graphic available
Description	Tectonic 3 precursor.

AUXI_HUMAN
θ value	5.27518 (rank : 27)	NC score	0.021202 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

MAST4_HUMAN
θ value	5.27518 (rank : 28)	NC score	0.002725 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	1804	Shared Neighborhood Hits	8
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SYP2L_HUMAN
θ value	5.27518 (rank : 29)	NC score	0.020644 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	400	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

AKAP8_MOUSE
θ value	6.88961 (rank : 30)	NC score	0.021765 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBR0, Q9R0L8	Gene names	Akap8, Akap95
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

CHD6_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.007973 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

EMID2_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.013417 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	226	Shared Neighborhood Hits	4
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

EP15R_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.008333 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	1135	Shared Neighborhood Hits	9
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

HIG1B_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.020584 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY6, Q8C1M5	Gene names	Higd1b
Domain Architecture	No domain graphic available
Description	HIG1 domain family member 1B.

IKBE_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.006794 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

MEFV_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.005130 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	431	Shared Neighborhood Hits	2
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MYOC_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.009982 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	489	Shared Neighborhood Hits	8
SwissProt Accessions	Q99972, O00620, Q7Z6Q9	Gene names	MYOC, GLC1A, TIGR
Domain Architecture
Description	Myocilin precursor (Trabecular meshwork-induced glucocorticoid response protein).

PRAM3_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.009069 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

REEP1_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.021589 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGH4	Gene names	Reep1, D6Ertd253e
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 1.

RHPN1_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.011650 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TDRD4_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.021405 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUY9	Gene names	TDRD4
Domain Architecture
Description	Tudor domain-containing protein 4.

APLP2_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.008717 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

BAZ1B_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.008553 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	701	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CE290_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.007598 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	1553	Shared Neighborhood Hits	12
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

EMID2_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.016594 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	201	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

HEM3_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.015429 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P22907	Gene names	Hmbs, Uros1
Domain Architecture
Description	Porphobilinogen deaminase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (PBG-D).

HIF1A_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.012080 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

INADL_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.006313 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

KBTBA_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.004020 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	184	Shared Neighborhood Hits	2
SwissProt Accessions	O60662	Gene names	KBTBD10, KRP1
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 10 (Kelch-related protein 1) (Kel-like protein 23) (Sarcosin).

TAF6_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.023963 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

YTHD2_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.017527 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

Hits sorted by NC score

INT1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

INT1_MOUSE
NC score	0.982007 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	44	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P4S8, Q80UQ7, Q91Z01, Q9CTF7	Gene names	Ints1
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

TF3B_MOUSE
NC score	0.056795 (rank : 3)	θ value	0.813845 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

REEP1_HUMAN
NC score	0.048919 (rank : 4)	θ value	0.47712 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H902, Q53TI0	Gene names	REEP1, C2orf23
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 1.

REC8L_HUMAN
NC score	0.043644 (rank : 5)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	O95072, Q8WUV8, Q9BTF2, Q9NVQ9	Gene names	REC8L1, REC8
Domain Architecture
Description	Meiotic recombination protein REC8-like 1 (Cohesin Rec8p).

CSF3_MOUSE
NC score	0.043496 (rank : 6)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P09920	Gene names	Csf3, Csfg
Domain Architecture
Description	Granulocyte colony-stimulating factor precursor (G-CSF).

SYWM_MOUSE
NC score	0.039863 (rank : 7)	θ value	1.38821 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CYK1	Gene names	Wars2
Domain Architecture
Description	Tryptophanyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) ((Mt)TrpRS).

OLIG2_HUMAN
NC score	0.032474 (rank : 8)	θ value	0.47712 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

TECT3_HUMAN
NC score	0.032193 (rank : 9)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NUS6, Q6P7P3, Q6UW27, Q6ZQQ0, Q8N7K1, Q8NBQ0, Q96GF7, Q9Y3U1	Gene names	TECT3, C10orf61
Domain Architecture	No domain graphic available
Description	Tectonic 3 precursor.

CTF1_MOUSE
NC score	0.029921 (rank : 10)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q60753	Gene names	Ctf1
Domain Architecture	No domain graphic available
Description	Cardiotrophin-1 (CT-1).

PI4KA_HUMAN
NC score	0.025255 (rank : 11)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

GROA_MOUSE
NC score	0.024943 (rank : 12)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P12850	Gene names	Cxcl1, Gro, Gro1, Mgsa, Scyb1
Domain Architecture
Description	Growth-regulated alpha protein precursor (CXCL1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Contains: KC(5-72) (KC-T) (Hematopoietic synergistic factor) (HSF)].

TAF6_MOUSE
NC score	0.023963 (rank : 13)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	110	Shared Neighborhood Hits	4
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

AKAP8_MOUSE
NC score	0.021765 (rank : 14)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBR0, Q9R0L8	Gene names	Akap8, Akap95
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

REEP1_MOUSE
NC score	0.021589 (rank : 15)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGH4	Gene names	Reep1, D6Ertd253e
Domain Architecture	No domain graphic available
Description	Receptor expression-enhancing protein 1.

NFH_MOUSE
NC score	0.021417 (rank : 16)	θ value	0.125558 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	2247	Shared Neighborhood Hits	19
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TDRD4_HUMAN
NC score	0.021405 (rank : 17)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NUY9	Gene names	TDRD4
Domain Architecture
Description	Tudor domain-containing protein 4.

AUXI_HUMAN
NC score	0.021202 (rank : 18)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

SYP2L_HUMAN
NC score	0.020644 (rank : 19)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	400	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SOX12_MOUSE
NC score	0.020635 (rank : 20)	θ value	0.813845 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q04890, P70417, Q6NXL2	Gene names	Sox12, Sox-12
Domain Architecture	No domain graphic available
Description	SOX-12 protein.

HIG1B_MOUSE
NC score	0.020584 (rank : 21)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY6, Q8C1M5	Gene names	Higd1b
Domain Architecture	No domain graphic available
Description	HIG1 domain family member 1B.

RSU1_MOUSE
NC score	0.018697 (rank : 22)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	239	Shared Neighborhood Hits	4
SwissProt Accessions	Q01730	Gene names	Rsu1, Rsp1
Domain Architecture	No domain graphic available
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

CEND3_MOUSE
NC score	0.017603 (rank : 23)	θ value	1.06291 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	228	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

YTHD2_HUMAN
NC score	0.017527 (rank : 24)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

EMID2_MOUSE
NC score	0.016594 (rank : 25)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	201	Shared Neighborhood Hits	5
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

RSU1_HUMAN
NC score	0.016451 (rank : 26)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	250	Shared Neighborhood Hits	4
SwissProt Accessions	Q15404	Gene names	RSU1, RSP1
Domain Architecture
Description	Ras suppressor protein 1 (Rsu-1) (RSP-1).

RAD50_MOUSE
NC score	0.016192 (rank : 27)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	1366	Shared Neighborhood Hits	12
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RAD50_HUMAN
NC score	0.015860 (rank : 28)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	1317	Shared Neighborhood Hits	11
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RBL1_MOUSE
NC score	0.015794 (rank : 29)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q64701	Gene names	Rbl1
Domain Architecture
Description	Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107).

HEM3_MOUSE
NC score	0.015429 (rank : 30)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	P22907	Gene names	Hmbs, Uros1
Domain Architecture
Description	Porphobilinogen deaminase (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) (PBG-D).

SOX12_HUMAN
NC score	0.014714 (rank : 31)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	O15370, Q9NUD4	Gene names	SOX12, SOX22
Domain Architecture
Description	SOX-12 protein (SOX-22 protein).

EMID2_HUMAN
NC score	0.013417 (rank : 32)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	226	Shared Neighborhood Hits	4
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

GSTA5_HUMAN
NC score	0.013067 (rank : 33)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q7RTV2	Gene names	GSTA5
Domain Architecture	No domain graphic available
Description	Glutathione S-transferase A5 (EC 2.5.1.18) (Glutathione S-transferase A5-5) (GST class-alpha member 5).

HIF1A_MOUSE
NC score	0.012080 (rank : 34)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

RHPN1_MOUSE
NC score	0.011650 (rank : 35)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	154	Shared Neighborhood Hits	5
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

PRGR_MOUSE
NC score	0.010067 (rank : 36)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

MYOC_HUMAN
NC score	0.009982 (rank : 37)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	489	Shared Neighborhood Hits	8
SwissProt Accessions	Q99972, O00620, Q7Z6Q9	Gene names	MYOC, GLC1A, TIGR
Domain Architecture
Description	Myocilin precursor (Trabecular meshwork-induced glucocorticoid response protein).

PRAM3_HUMAN
NC score	0.009069 (rank : 38)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TYW8	Gene names	PRAMEF3
Domain Architecture	No domain graphic available
Description	PRAME family member 3.

MYH10_HUMAN
NC score	0.008947 (rank : 39)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	1620	Shared Neighborhood Hits	11
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

APLP2_HUMAN
NC score	0.008717 (rank : 40)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

MYH10_MOUSE
NC score	0.008672 (rank : 41)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	1612	Shared Neighborhood Hits	11
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

BAZ1B_HUMAN
NC score	0.008553 (rank : 42)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	701	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

EP15R_MOUSE
NC score	0.008333 (rank : 43)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	1135	Shared Neighborhood Hits	9
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

CHD6_HUMAN
NC score	0.007973 (rank : 44)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	342	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

CE290_HUMAN
NC score	0.007598 (rank : 45)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	1553	Shared Neighborhood Hits	12
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

IKBE_HUMAN
NC score	0.006794 (rank : 46)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

INADL_MOUSE
NC score	0.006313 (rank : 47)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

MEFV_HUMAN
NC score	0.005130 (rank : 48)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	431	Shared Neighborhood Hits	2
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

KBTBA_HUMAN
NC score	0.004020 (rank : 49)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	184	Shared Neighborhood Hits	2
SwissProt Accessions	O60662	Gene names	KBTBD10, KRP1
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 10 (Kelch-related protein 1) (Kel-like protein 23) (Sarcosin).

MAST4_HUMAN
NC score	0.002725 (rank : 50)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	1804	Shared Neighborhood Hits	8
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MARK3_MOUSE
NC score	0.001682 (rank : 51)	θ value	4.03905 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	919	Shared Neighborhood Hits	4
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).