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Network neighborhood for query Sequence : MAST4_HUMAN

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MAST4_HUMAN
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MAST1_HUMAN
θ value	0 (rank : 1)	NC score	0.980578 (rank : 2)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1146	Shared Neighborhood Hits	1021
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	0 (rank : 2)	NC score	0.980081 (rank : 4)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	1010
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	0 (rank : 3)	NC score	0.980010 (rank : 6)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1189	Shared Neighborhood Hits	1031
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	0 (rank : 4)	NC score	0.980046 (rank : 5)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1110	Shared Neighborhood Hits	1009
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
θ value	0 (rank : 5)	NC score	0.980381 (rank : 3)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1128	Shared Neighborhood Hits	1026
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	0 (rank : 6)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1804
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

LATS1_HUMAN
θ value	3.35642e-63 (rank : 7)	NC score	0.943497 (rank : 68)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1057	Shared Neighborhood Hits	904
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

AKT2_MOUSE
θ value	5.35859e-61 (rank : 8)	NC score	0.951916 (rank : 21)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	827
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

LATS1_MOUSE
θ value	5.35859e-61 (rank : 9)	NC score	0.942495 (rank : 71)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1027	Shared Neighborhood Hits	883
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

AKT2_HUMAN
θ value	6.99855e-61 (rank : 10)	NC score	0.951971 (rank : 20)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	827
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ST38L_MOUSE
θ value	1.01059e-59 (rank : 11)	NC score	0.946471 (rank : 44)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	789
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

AKT1_HUMAN
θ value	1.7238e-59 (rank : 12)	NC score	0.950696 (rank : 28)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	828
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KAPCB_MOUSE
θ value	3.84025e-59 (rank : 13)	NC score	0.955720 (rank : 10)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

ST38L_HUMAN
θ value	3.84025e-59 (rank : 14)	NC score	0.949034 (rank : 32)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	795
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

KAPCA_HUMAN
θ value	5.0155e-59 (rank : 15)	NC score	0.956058 (rank : 8)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	829
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	5.0155e-59 (rank : 16)	NC score	0.955915 (rank : 9)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	827
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

AKT3_HUMAN
θ value	6.55044e-59 (rank : 17)	NC score	0.952630 (rank : 18)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT1_MOUSE
θ value	1.45929e-58 (rank : 18)	NC score	0.950758 (rank : 27)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	826
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT3_MOUSE
θ value	1.45929e-58 (rank : 19)	NC score	0.952626 (rank : 19)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KAPCB_HUMAN
θ value	3.25095e-58 (rank : 20)	NC score	0.955535 (rank : 11)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

ROCK1_HUMAN
θ value	5.54529e-58 (rank : 21)	NC score	0.845441 (rank : 418)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2000	Shared Neighborhood Hits	926
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	7.24236e-58 (rank : 22)	NC score	0.828907 (rank : 489)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2126	Shared Neighborhood Hits	945
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

KS6A3_HUMAN
θ value	1.23536e-57 (rank : 23)	NC score	0.945161 (rank : 53)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	839
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	1.23536e-57 (rank : 24)	NC score	0.945140 (rank : 55)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	839
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

ROCK2_MOUSE
θ value	1.61343e-57 (rank : 25)	NC score	0.842893 (rank : 431)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2072	Shared Neighborhood Hits	936
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

KS6A1_HUMAN
θ value	4.69435e-57 (rank : 26)	NC score	0.945762 (rank : 46)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A6_HUMAN
θ value	4.69435e-57 (rank : 27)	NC score	0.946806 (rank : 43)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	837
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

STK38_HUMAN
θ value	4.69435e-57 (rank : 28)	NC score	0.948557 (rank : 34)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	801
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

LATS2_HUMAN
θ value	6.13105e-57 (rank : 29)	NC score	0.940499 (rank : 76)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	839
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

STK38_MOUSE
θ value	8.00737e-57 (rank : 30)	NC score	0.948571 (rank : 33)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	801
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KPCT_HUMAN
θ value	1.78386e-56 (rank : 31)	NC score	0.943121 (rank : 70)
Query Neighborhood Hits	1804	Target Neighborhood Hits	897	Shared Neighborhood Hits	837
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	2.32979e-56 (rank : 32)	NC score	0.943566 (rank : 67)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	834
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KAPCG_HUMAN
θ value	3.0428e-56 (rank : 33)	NC score	0.956137 (rank : 7)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	830
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

PRKX_HUMAN
θ value	5.19021e-56 (rank : 34)	NC score	0.954627 (rank : 12)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KS6A2_HUMAN
θ value	6.77864e-56 (rank : 35)	NC score	0.945330 (rank : 52)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	838
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

ROCK2_HUMAN
θ value	8.85319e-56 (rank : 36)	NC score	0.849508 (rank : 404)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2073	Shared Neighborhood Hits	934
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

KS6A2_MOUSE
θ value	1.51013e-55 (rank : 37)	NC score	0.945552 (rank : 50)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	839
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

LATS2_MOUSE
θ value	4.39379e-55 (rank : 38)	NC score	0.940261 (rank : 77)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	843
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MRCKG_HUMAN
θ value	7.49467e-55 (rank : 39)	NC score	0.910615 (rank : 215)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1519	Shared Neighborhood Hits	893
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
θ value	2.18062e-54 (rank : 40)	NC score	0.908931 (rank : 223)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1466	Shared Neighborhood Hits	871
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KS6B1_HUMAN
θ value	2.84797e-54 (rank : 41)	NC score	0.953535 (rank : 16)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KPCL_MOUSE
θ value	4.85792e-54 (rank : 42)	NC score	0.943886 (rank : 66)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

PKN2_MOUSE
θ value	4.85792e-54 (rank : 43)	NC score	0.945001 (rank : 56)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	827
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

DMPK_HUMAN
θ value	6.34462e-54 (rank : 44)	NC score	0.945810 (rank : 45)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	831
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

PKN2_HUMAN
θ value	8.28633e-54 (rank : 45)	NC score	0.944713 (rank : 59)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	828
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KPCL_HUMAN
θ value	1.08223e-53 (rank : 46)	NC score	0.943494 (rank : 69)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	820
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6B1_MOUSE
θ value	1.08223e-53 (rank : 47)	NC score	0.953517 (rank : 17)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	1.84601e-53 (rank : 48)	NC score	0.954010 (rank : 14)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

DMPK_MOUSE
θ value	2.41096e-53 (rank : 49)	NC score	0.945557 (rank : 49)
Query Neighborhood Hits	1804	Target Neighborhood Hits	908	Shared Neighborhood Hits	825
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KS6B2_MOUSE
θ value	2.41096e-53 (rank : 50)	NC score	0.954145 (rank : 13)
Query Neighborhood Hits	1804	Target Neighborhood Hits	871	Shared Neighborhood Hits	847
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PKN1_HUMAN
θ value	2.41096e-53 (rank : 51)	NC score	0.944698 (rank : 60)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	7.01481e-53 (rank : 52)	NC score	0.944263 (rank : 65)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PRKX_MOUSE
θ value	9.16162e-53 (rank : 53)	NC score	0.953647 (rank : 15)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	833
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

MRCKA_HUMAN
θ value	7.75577e-52 (rank : 54)	NC score	0.853052 (rank : 391)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1999	Shared Neighborhood Hits	920
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

KS6A1_MOUSE
θ value	3.84914e-51 (rank : 55)	NC score	0.945150 (rank : 54)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PKN3_MOUSE
θ value	6.56568e-51 (rank : 56)	NC score	0.945609 (rank : 48)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	887
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

MRCKB_HUMAN
θ value	8.57503e-51 (rank : 57)	NC score	0.831447 (rank : 476)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2239	Shared Neighborhood Hits	973
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_MOUSE
θ value	2.49495e-50 (rank : 58)	NC score	0.839525 (rank : 442)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2180	Shared Neighborhood Hits	955
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

KPCB_HUMAN
θ value	4.25575e-50 (rank : 59)	NC score	0.917383 (rank : 168)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1121	Shared Neighborhood Hits	832
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCE_MOUSE
θ value	4.25575e-50 (rank : 60)	NC score	0.941510 (rank : 73)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	831
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PKN3_HUMAN
θ value	5.55816e-50 (rank : 61)	NC score	0.946816 (rank : 42)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KPCE_HUMAN
θ value	9.48078e-50 (rank : 62)	NC score	0.941507 (rank : 74)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	829
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KGP1B_MOUSE
θ value	3.60269e-49 (rank : 63)	NC score	0.938358 (rank : 83)
Query Neighborhood Hits	1804	Target Neighborhood Hits	922	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
θ value	6.14528e-49 (rank : 64)	NC score	0.938732 (rank : 81)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	838
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	6.14528e-49 (rank : 65)	NC score	0.938256 (rank : 84)
Query Neighborhood Hits	1804	Target Neighborhood Hits	921	Shared Neighborhood Hits	839
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KPCA_HUMAN
θ value	6.14528e-49 (rank : 66)	NC score	0.919167 (rank : 157)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1070	Shared Neighborhood Hits	834
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KS6A4_HUMAN
θ value	6.14528e-49 (rank : 67)	NC score	0.948265 (rank : 35)
Query Neighborhood Hits	1804	Target Neighborhood Hits	868	Shared Neighborhood Hits	844
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KPCI_MOUSE
θ value	8.02596e-49 (rank : 68)	NC score	0.947002 (rank : 40)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCD_MOUSE
θ value	1.04822e-48 (rank : 69)	NC score	0.939944 (rank : 78)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	830
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_HUMAN
θ value	1.788e-48 (rank : 70)	NC score	0.939672 (rank : 79)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	832
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCZ_HUMAN
θ value	1.788e-48 (rank : 71)	NC score	0.944721 (rank : 58)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCA_MOUSE
θ value	2.3352e-48 (rank : 72)	NC score	0.919502 (rank : 152)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1067	Shared Neighborhood Hits	830
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KS6A4_MOUSE
θ value	3.04986e-48 (rank : 73)	NC score	0.947857 (rank : 36)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

SGK3_MOUSE
θ value	3.04986e-48 (rank : 74)	NC score	0.947633 (rank : 38)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	826
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

KPCB_MOUSE
θ value	3.98324e-48 (rank : 75)	NC score	0.916249 (rank : 172)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1117	Shared Neighborhood Hits	832
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCI_HUMAN
θ value	3.98324e-48 (rank : 76)	NC score	0.946969 (rank : 41)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	837
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCZ_MOUSE
θ value	5.20228e-48 (rank : 77)	NC score	0.944744 (rank : 57)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	833
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

SGK2_HUMAN
θ value	2.58187e-47 (rank : 78)	NC score	0.951807 (rank : 22)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK1_HUMAN
θ value	4.40402e-47 (rank : 79)	NC score	0.951576 (rank : 25)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	831
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK3_HUMAN
θ value	4.40402e-47 (rank : 80)	NC score	0.947522 (rank : 39)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	825
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK1_MOUSE
θ value	1.28137e-46 (rank : 81)	NC score	0.951445 (rank : 26)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KPCG_HUMAN
θ value	2.18568e-46 (rank : 82)	NC score	0.914795 (rank : 191)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1126	Shared Neighborhood Hits	836
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A5_HUMAN
θ value	2.85459e-46 (rank : 83)	NC score	0.947679 (rank : 37)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	837
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KPCG_MOUSE
θ value	6.35935e-46 (rank : 84)	NC score	0.914835 (rank : 190)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	834
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KS6A5_MOUSE
θ value	1.85029e-45 (rank : 85)	NC score	0.949690 (rank : 29)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

SGK2_MOUSE
θ value	3.15612e-45 (rank : 86)	NC score	0.951673 (rank : 24)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	824
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KGP2_HUMAN
θ value	4.122e-45 (rank : 87)	NC score	0.937569 (rank : 85)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	850
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	2.67181e-44 (rank : 88)	NC score	0.937277 (rank : 87)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1029	Shared Neighborhood Hits	847
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PDPK1_MOUSE
θ value	5.95217e-44 (rank : 89)	NC score	0.949483 (rank : 30)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PRKY_HUMAN
θ value	1.32601e-43 (rank : 90)	NC score	0.951741 (rank : 23)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	834
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PDPK1_HUMAN
θ value	1.73182e-43 (rank : 91)	NC score	0.949439 (rank : 31)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

CTRO_HUMAN
θ value	2.95404e-43 (rank : 92)	NC score	0.837605 (rank : 449)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2092	Shared Neighborhood Hits	963
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	2.11701e-41 (rank : 93)	NC score	0.812820 (rank : 531)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2344	Shared Neighborhood Hits	983
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GRK7_HUMAN
θ value	3.4976e-36 (rank : 94)	NC score	0.938467 (rank : 82)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	814
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

GRK6_MOUSE
θ value	2.96089e-35 (rank : 95)	NC score	0.934585 (rank : 92)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ST32A_MOUSE
θ value	6.59618e-35 (rank : 96)	NC score	0.945413 (rank : 51)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

GRK6_HUMAN
θ value	3.27365e-34 (rank : 97)	NC score	0.934823 (rank : 91)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	814
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ST32A_HUMAN
θ value	3.27365e-34 (rank : 98)	NC score	0.945643 (rank : 47)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

MASTL_MOUSE
θ value	5.584e-34 (rank : 99)	NC score	0.940719 (rank : 75)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RK_HUMAN
θ value	9.52487e-34 (rank : 100)	NC score	0.939272 (rank : 80)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	820
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MASTL_HUMAN
θ value	1.24399e-33 (rank : 101)	NC score	0.941516 (rank : 72)
Query Neighborhood Hits	1804	Target Neighborhood Hits	894	Shared Neighborhood Hits	844
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

ST32B_HUMAN
θ value	2.77131e-33 (rank : 102)	NC score	0.944649 (rank : 61)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	824
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	2.77131e-33 (rank : 103)	NC score	0.944596 (rank : 63)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

GRK5_MOUSE
θ value	8.06329e-33 (rank : 104)	NC score	0.933987 (rank : 94)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	807
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_HUMAN
θ value	1.0531e-32 (rank : 105)	NC score	0.933931 (rank : 95)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	807
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

RK_MOUSE
θ value	1.0531e-32 (rank : 106)	NC score	0.937480 (rank : 86)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	818
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

DCAK3_HUMAN
θ value	2.34606e-32 (rank : 107)	NC score	0.929620 (rank : 104)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	846
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

GRK4_HUMAN
θ value	5.22648e-32 (rank : 108)	NC score	0.933210 (rank : 98)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	807
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

STK36_HUMAN
θ value	5.22648e-32 (rank : 109)	NC score	0.917937 (rank : 163)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	847
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ARBK2_HUMAN
θ value	8.91499e-32 (rank : 110)	NC score	0.936949 (rank : 88)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	818
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

STK6_HUMAN
θ value	1.98606e-31 (rank : 111)	NC score	0.932199 (rank : 101)
Query Neighborhood Hits	1804	Target Neighborhood Hits	916	Shared Neighborhood Hits	861
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

ST32C_HUMAN
θ value	2.59387e-31 (rank : 112)	NC score	0.944486 (rank : 64)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	2.59387e-31 (rank : 113)	NC score	0.944627 (rank : 62)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	817
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ARBK1_MOUSE
θ value	5.77852e-31 (rank : 114)	NC score	0.936188 (rank : 90)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	820
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK1_HUMAN
θ value	7.54701e-31 (rank : 115)	NC score	0.936271 (rank : 89)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	819
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

BRSK1_HUMAN
θ value	9.8567e-31 (rank : 116)	NC score	0.925175 (rank : 120)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	869
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

DCAK3_MOUSE
θ value	1.6813e-30 (rank : 117)	NC score	0.928456 (rank : 107)
Query Neighborhood Hits	1804	Target Neighborhood Hits	922	Shared Neighborhood Hits	864
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

AURKB_HUMAN
θ value	2.19584e-30 (rank : 118)	NC score	0.932984 (rank : 99)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

GRK4_MOUSE
θ value	2.19584e-30 (rank : 119)	NC score	0.930162 (rank : 103)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	801
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

STK36_MOUSE
θ value	2.19584e-30 (rank : 120)	NC score	0.915767 (rank : 179)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	841
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

AURKC_HUMAN
θ value	2.86786e-30 (rank : 121)	NC score	0.933305 (rank : 97)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

PLK4_MOUSE
θ value	3.74554e-30 (rank : 122)	NC score	0.927110 (rank : 110)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	839
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

STK6_MOUSE
θ value	1.08979e-29 (rank : 123)	NC score	0.932813 (rank : 100)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	850
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

KCC1B_MOUSE
θ value	1.85889e-29 (rank : 124)	NC score	0.925621 (rank : 117)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	827
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1B_HUMAN
θ value	2.42779e-29 (rank : 125)	NC score	0.925687 (rank : 116)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	827
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

NUAK1_HUMAN
θ value	2.42779e-29 (rank : 126)	NC score	0.920352 (rank : 141)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	2.42779e-29 (rank : 127)	NC score	0.920690 (rank : 139)
Query Neighborhood Hits	1804	Target Neighborhood Hits	881	Shared Neighborhood Hits	849
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

PLK4_HUMAN
θ value	2.42779e-29 (rank : 128)	NC score	0.927241 (rank : 109)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

AURKC_MOUSE
θ value	3.17079e-29 (rank : 129)	NC score	0.933449 (rank : 96)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

BRSK2_HUMAN
θ value	5.40856e-29 (rank : 130)	NC score	0.922414 (rank : 133)
Query Neighborhood Hits	1804	Target Neighborhood Hits	897	Shared Neighborhood Hits	853
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

AURKB_MOUSE
θ value	7.06379e-29 (rank : 131)	NC score	0.934158 (rank : 93)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	839
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

MARK2_HUMAN
θ value	1.2049e-28 (rank : 132)	NC score	0.918071 (rank : 161)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	921
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

KCC1G_HUMAN
θ value	1.57365e-28 (rank : 133)	NC score	0.925216 (rank : 119)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	830
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	2.05525e-28 (rank : 134)	NC score	0.925447 (rank : 118)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	834
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MARK2_MOUSE
θ value	2.05525e-28 (rank : 135)	NC score	0.917395 (rank : 167)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1018	Shared Neighborhood Hits	913
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

ULK2_MOUSE
θ value	2.05525e-28 (rank : 136)	NC score	0.916171 (rank : 174)
Query Neighborhood Hits	1804	Target Neighborhood Hits	943	Shared Neighborhood Hits	888
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KKCC2_HUMAN
θ value	2.68423e-28 (rank : 137)	NC score	0.926637 (rank : 114)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	832
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	2.68423e-28 (rank : 138)	NC score	0.926897 (rank : 111)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	833
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPSH1_MOUSE
θ value	2.68423e-28 (rank : 139)	NC score	0.924451 (rank : 123)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

ULK2_HUMAN
θ value	2.68423e-28 (rank : 140)	NC score	0.915385 (rank : 187)
Query Neighborhood Hits	1804	Target Neighborhood Hits	979	Shared Neighborhood Hits	892
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

MARK3_MOUSE
θ value	3.50572e-28 (rank : 141)	NC score	0.915426 (rank : 186)
Query Neighborhood Hits	1804	Target Neighborhood Hits	919	Shared Neighborhood Hits	868
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK1_HUMAN
θ value	4.57862e-28 (rank : 142)	NC score	0.914356 (rank : 196)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	847
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	4.57862e-28 (rank : 143)	NC score	0.914530 (rank : 194)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	847
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

NUAK2_HUMAN
θ value	4.57862e-28 (rank : 144)	NC score	0.921879 (rank : 135)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

TSSK4_MOUSE
θ value	4.57862e-28 (rank : 145)	NC score	0.923435 (rank : 128)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KCC1D_HUMAN
θ value	5.97985e-28 (rank : 146)	NC score	0.926761 (rank : 113)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	5.97985e-28 (rank : 147)	NC score	0.926783 (rank : 112)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

ULK1_MOUSE
θ value	7.80994e-28 (rank : 148)	NC score	0.917718 (rank : 166)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1214	Shared Neighborhood Hits	998
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

KPSH1_HUMAN
θ value	1.02001e-27 (rank : 149)	NC score	0.924410 (rank : 124)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	825
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

SN1L2_MOUSE
θ value	1.02001e-27 (rank : 150)	NC score	0.911835 (rank : 203)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	860
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

NUAK2_MOUSE
θ value	1.73987e-27 (rank : 151)	NC score	0.923003 (rank : 130)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	848
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

SN1L2_HUMAN
θ value	1.73987e-27 (rank : 152)	NC score	0.911792 (rank : 205)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	881
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

STK3_HUMAN
θ value	2.27234e-27 (rank : 153)	NC score	0.888200 (rank : 292)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	838
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

AAPK1_MOUSE
θ value	2.96777e-27 (rank : 154)	NC score	0.919735 (rank : 150)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	830
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KCC2G_HUMAN
θ value	3.87602e-27 (rank : 155)	NC score	0.916162 (rank : 175)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	825
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	3.87602e-27 (rank : 156)	NC score	0.916127 (rank : 176)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

SNRK_MOUSE
θ value	3.87602e-27 (rank : 157)	NC score	0.919779 (rank : 148)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	816
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

AAPK1_HUMAN
θ value	5.06226e-27 (rank : 158)	NC score	0.919169 (rank : 156)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	830
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KCC4_MOUSE
θ value	5.06226e-27 (rank : 159)	NC score	0.921954 (rank : 134)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	835
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC2A_HUMAN
θ value	8.63488e-27 (rank : 160)	NC score	0.915547 (rank : 184)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

ULK1_HUMAN
θ value	8.63488e-27 (rank : 161)	NC score	0.916051 (rank : 177)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1121	Shared Neighborhood Hits	956
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

KCC1A_HUMAN
θ value	1.12775e-26 (rank : 162)	NC score	0.924862 (rank : 122)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	830
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

SNRK_HUMAN
θ value	1.12775e-26 (rank : 163)	NC score	0.921068 (rank : 137)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	820
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KCC1A_MOUSE
θ value	1.47289e-26 (rank : 164)	NC score	0.924922 (rank : 121)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	830
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MARK4_HUMAN
θ value	1.47289e-26 (rank : 165)	NC score	0.916199 (rank : 173)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	852
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	1.47289e-26 (rank : 166)	NC score	0.916026 (rank : 178)
Query Neighborhood Hits	1804	Target Neighborhood Hits	898	Shared Neighborhood Hits	853
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

SN1L1_HUMAN
θ value	1.47289e-26 (rank : 167)	NC score	0.914724 (rank : 192)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	854
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

AAPK2_HUMAN
θ value	2.51237e-26 (rank : 168)	NC score	0.920197 (rank : 144)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	830
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

SN1L1_MOUSE
θ value	2.51237e-26 (rank : 169)	NC score	0.912818 (rank : 202)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	856
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

CHK2_MOUSE
θ value	3.28125e-26 (rank : 170)	NC score	0.923266 (rank : 129)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KPSH2_HUMAN
θ value	3.28125e-26 (rank : 171)	NC score	0.927461 (rank : 108)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	811
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KKCC1_MOUSE
θ value	4.28545e-26 (rank : 172)	NC score	0.930233 (rank : 102)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	840
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KCC2A_MOUSE
θ value	5.59698e-26 (rank : 173)	NC score	0.914690 (rank : 193)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	815
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

DCAK2_MOUSE
θ value	7.30988e-26 (rank : 174)	NC score	0.909411 (rank : 218)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KCC4_HUMAN
θ value	7.30988e-26 (rank : 175)	NC score	0.921220 (rank : 136)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KPCD2_HUMAN
θ value	7.30988e-26 (rank : 176)	NC score	0.911809 (rank : 204)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	832
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

DCAK2_HUMAN
θ value	9.54697e-26 (rank : 177)	NC score	0.909150 (rank : 220)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	831
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KCC2D_HUMAN
θ value	9.54697e-26 (rank : 178)	NC score	0.915528 (rank : 185)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

STK33_HUMAN
θ value	9.54697e-26 (rank : 179)	NC score	0.922653 (rank : 132)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	838
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KPCD1_HUMAN
θ value	1.24688e-25 (rank : 180)	NC score	0.911367 (rank : 208)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	830
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

STK3_MOUSE
θ value	1.24688e-25 (rank : 181)	NC score	0.887580 (rank : 295)
Query Neighborhood Hits	1804	Target Neighborhood Hits	869	Shared Neighborhood Hits	838
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CHK2_HUMAN
θ value	1.62847e-25 (rank : 182)	NC score	0.924294 (rank : 125)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	827
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

ULK3_MOUSE
θ value	1.62847e-25 (rank : 183)	NC score	0.922766 (rank : 131)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CSKP_HUMAN
θ value	2.12685e-25 (rank : 184)	NC score	0.869588 (rank : 350)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1022	Shared Neighborhood Hits	877
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	2.12685e-25 (rank : 185)	NC score	0.871940 (rank : 346)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1027	Shared Neighborhood Hits	879
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

KPCD1_MOUSE
θ value	2.77775e-25 (rank : 186)	NC score	0.911306 (rank : 210)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	829
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

DCAK1_HUMAN
θ value	6.18819e-25 (rank : 187)	NC score	0.908502 (rank : 227)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	839
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	6.18819e-25 (rank : 188)	NC score	0.908634 (rank : 225)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	837
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

K0999_MOUSE
θ value	6.18819e-25 (rank : 189)	NC score	0.911535 (rank : 206)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	868
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

DAPK2_MOUSE
θ value	8.08199e-25 (rank : 190)	NC score	0.916969 (rank : 170)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	8.08199e-25 (rank : 191)	NC score	0.911405 (rank : 207)
Query Neighborhood Hits	1804	Target Neighborhood Hits	945	Shared Neighborhood Hits	827
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

K0999_HUMAN
θ value	8.08199e-25 (rank : 192)	NC score	0.911272 (rank : 211)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

NIM1_MOUSE
θ value	1.37858e-24 (rank : 193)	NC score	0.916940 (rank : 171)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

OBSCN_HUMAN
θ value	1.37858e-24 (rank : 194)	NC score	0.813609 (rank : 528)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1063
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

STK4_HUMAN
θ value	1.37858e-24 (rank : 195)	NC score	0.885773 (rank : 300)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	834
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

TSSK4_HUMAN
θ value	1.37858e-24 (rank : 196)	NC score	0.920364 (rank : 140)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

DAPK1_HUMAN
θ value	1.80048e-24 (rank : 197)	NC score	0.825991 (rank : 494)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1130	Shared Neighborhood Hits	843
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KKCC1_HUMAN
θ value	1.80048e-24 (rank : 198)	NC score	0.929127 (rank : 106)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	838
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PAK7_HUMAN
θ value	1.80048e-24 (rank : 199)	NC score	0.903712 (rank : 239)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	841
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

DAPK3_MOUSE
θ value	2.35151e-24 (rank : 200)	NC score	0.913006 (rank : 201)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	818
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

NIM1_HUMAN
θ value	2.35151e-24 (rank : 201)	NC score	0.915673 (rank : 181)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	828
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PAK6_HUMAN
θ value	2.35151e-24 (rank : 202)	NC score	0.905409 (rank : 234)
Query Neighborhood Hits	1804	Target Neighborhood Hits	915	Shared Neighborhood Hits	870
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

STK4_MOUSE
θ value	2.35151e-24 (rank : 203)	NC score	0.885702 (rank : 301)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

DAPK2_HUMAN
θ value	4.01107e-24 (rank : 204)	NC score	0.915281 (rank : 188)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MARK3_HUMAN
θ value	4.01107e-24 (rank : 205)	NC score	0.910431 (rank : 217)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	851
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

NEK3_HUMAN
θ value	4.01107e-24 (rank : 206)	NC score	0.913343 (rank : 199)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	835
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

PAK7_MOUSE
θ value	4.01107e-24 (rank : 207)	NC score	0.903638 (rank : 241)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	845
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

CDK6_MOUSE
θ value	5.23862e-24 (rank : 208)	NC score	0.858756 (rank : 374)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

DAPK1_MOUSE
θ value	5.23862e-24 (rank : 209)	NC score	0.822092 (rank : 501)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1138	Shared Neighborhood Hits	842
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KCC2B_HUMAN
θ value	5.23862e-24 (rank : 210)	NC score	0.915666 (rank : 182)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	835
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	5.23862e-24 (rank : 211)	NC score	0.913208 (rank : 200)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

PLK1_MOUSE
θ value	6.84181e-24 (rank : 212)	NC score	0.923851 (rank : 127)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PAK2_MOUSE
θ value	8.93572e-24 (rank : 213)	NC score	0.901194 (rank : 246)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	841
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

MYLK_HUMAN
θ value	1.16704e-23 (rank : 214)	NC score	0.839535 (rank : 441)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1328	Shared Neighborhood Hits	878
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PLK1_HUMAN
θ value	1.5242e-23 (rank : 215)	NC score	0.923917 (rank : 126)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	828
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

ST17A_HUMAN
θ value	1.5242e-23 (rank : 216)	NC score	0.920326 (rank : 142)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

TSSK3_HUMAN
θ value	1.5242e-23 (rank : 217)	NC score	0.904483 (rank : 236)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	799
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CDK6_HUMAN
θ value	1.99067e-23 (rank : 218)	NC score	0.857761 (rank : 377)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

KPCD3_HUMAN
θ value	1.99067e-23 (rank : 219)	NC score	0.908944 (rank : 222)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	828
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

PLK2_HUMAN
θ value	1.99067e-23 (rank : 220)	NC score	0.919765 (rank : 149)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	834
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	1.99067e-23 (rank : 221)	NC score	0.919218 (rank : 155)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	1.99067e-23 (rank : 222)	NC score	0.918718 (rank : 158)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	838
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	1.99067e-23 (rank : 223)	NC score	0.918240 (rank : 160)
Query Neighborhood Hits	1804	Target Neighborhood Hits	863	Shared Neighborhood Hits	836
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

KPCD3_MOUSE
θ value	3.39556e-23 (rank : 224)	NC score	0.908677 (rank : 224)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	826
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

PAK1_HUMAN
θ value	5.79196e-23 (rank : 225)	NC score	0.899452 (rank : 254)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	848
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	5.79196e-23 (rank : 226)	NC score	0.899099 (rank : 255)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	851
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	7.56453e-23 (rank : 227)	NC score	0.901044 (rank : 248)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	843
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PHKG2_MOUSE
θ value	1.29031e-22 (rank : 228)	NC score	0.920012 (rank : 145)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	829
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

M4K3_HUMAN
θ value	1.6852e-22 (rank : 229)	NC score	0.881150 (rank : 319)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MELK_MOUSE
θ value	1.6852e-22 (rank : 230)	NC score	0.919803 (rank : 147)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

NEK4_HUMAN
θ value	1.6852e-22 (rank : 231)	NC score	0.899984 (rank : 251)
Query Neighborhood Hits	1804	Target Neighborhood Hits	883	Shared Neighborhood Hits	837
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PAK3_HUMAN
θ value	2.20094e-22 (rank : 232)	NC score	0.899533 (rank : 253)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	854
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	2.20094e-22 (rank : 233)	NC score	0.899538 (rank : 252)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

MP2K1_HUMAN
θ value	2.87452e-22 (rank : 234)	NC score	0.895976 (rank : 266)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MYLK_MOUSE
θ value	2.87452e-22 (rank : 235)	NC score	0.843181 (rank : 428)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1489	Shared Neighborhood Hits	989
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NEK3_MOUSE
θ value	2.87452e-22 (rank : 236)	NC score	0.914328 (rank : 197)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	832
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

TRIO_HUMAN
θ value	4.9032e-22 (rank : 237)	NC score	0.831816 (rank : 475)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1580	Shared Neighborhood Hits	898
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PHKG2_HUMAN
θ value	6.40375e-22 (rank : 238)	NC score	0.919284 (rank : 154)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	828
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

MELK_HUMAN
θ value	8.36355e-22 (rank : 239)	NC score	0.919463 (rank : 153)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	833
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MP2K1_MOUSE
θ value	1.09232e-21 (rank : 240)	NC score	0.895832 (rank : 269)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

TSSK3_MOUSE
θ value	1.09232e-21 (rank : 241)	NC score	0.903689 (rank : 240)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	799
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

NEK1_MOUSE
θ value	1.42661e-21 (rank : 242)	NC score	0.901167 (rank : 247)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1311	Shared Neighborhood Hits	907
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

F5006_MOUSE
θ value	1.86321e-21 (rank : 243)	NC score	0.929458 (rank : 105)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	792
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MAPK3_HUMAN
θ value	1.86321e-21 (rank : 244)	NC score	0.909249 (rank : 219)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	793
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MYLK2_HUMAN
θ value	1.86321e-21 (rank : 245)	NC score	0.913463 (rank : 198)
Query Neighborhood Hits	1804	Target Neighborhood Hits	920	Shared Neighborhood Hits	867
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK1_HUMAN
θ value	1.86321e-21 (rank : 246)	NC score	0.901696 (rank : 244)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1129	Shared Neighborhood Hits	873
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

MAPK3_MOUSE
θ value	2.43343e-21 (rank : 247)	NC score	0.910712 (rank : 214)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	803
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

NEK7_HUMAN
θ value	2.43343e-21 (rank : 248)	NC score	0.895875 (rank : 268)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	835
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

HUNK_HUMAN
θ value	3.17815e-21 (rank : 249)	NC score	0.920778 (rank : 138)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	848
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

NEK4_MOUSE
θ value	3.17815e-21 (rank : 250)	NC score	0.900997 (rank : 249)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

TSSK1_HUMAN
θ value	3.17815e-21 (rank : 251)	NC score	0.908995 (rank : 221)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDKL5_HUMAN
θ value	4.15078e-21 (rank : 252)	NC score	0.883880 (rank : 309)
Query Neighborhood Hits	1804	Target Neighborhood Hits	967	Shared Neighborhood Hits	873
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

NEK7_MOUSE
θ value	5.42112e-21 (rank : 253)	NC score	0.896072 (rank : 265)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK6_HUMAN
θ value	7.0802e-21 (rank : 254)	NC score	0.898523 (rank : 257)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	836
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

MP2K2_MOUSE
θ value	9.24701e-21 (rank : 255)	NC score	0.893794 (rank : 279)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

NEK11_HUMAN
θ value	9.24701e-21 (rank : 256)	NC score	0.894320 (rank : 274)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1043	Shared Neighborhood Hits	861
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK4_HUMAN
θ value	9.24701e-21 (rank : 257)	NC score	0.904786 (rank : 235)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	873
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CHK1_HUMAN
θ value	1.2077e-20 (rank : 258)	NC score	0.917829 (rank : 165)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	831
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	1.2077e-20 (rank : 259)	NC score	0.917908 (rank : 164)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	834
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

HUNK_MOUSE
θ value	1.2077e-20 (rank : 260)	NC score	0.920204 (rank : 143)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

NEK6_MOUSE
θ value	1.2077e-20 (rank : 261)	NC score	0.898266 (rank : 259)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	837
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

OXSR1_MOUSE
θ value	1.2077e-20 (rank : 262)	NC score	0.881987 (rank : 315)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	839
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PHKG1_HUMAN
θ value	1.2077e-20 (rank : 263)	NC score	0.917030 (rank : 169)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	829
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ST17B_MOUSE
θ value	1.2077e-20 (rank : 264)	NC score	0.915559 (rank : 183)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

F5006_HUMAN
θ value	1.5773e-20 (rank : 265)	NC score	0.925923 (rank : 115)
Query Neighborhood Hits	1804	Target Neighborhood Hits	794	Shared Neighborhood Hits	787
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MP2K2_HUMAN
θ value	1.5773e-20 (rank : 266)	NC score	0.895910 (rank : 267)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PAK4_MOUSE
θ value	1.5773e-20 (rank : 267)	NC score	0.904172 (rank : 237)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1098	Shared Neighborhood Hits	955
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ULK3_HUMAN
θ value	1.5773e-20 (rank : 268)	NC score	0.919643 (rank : 151)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CDK3_HUMAN
θ value	2.06002e-20 (rank : 269)	NC score	0.863141 (rank : 366)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

OXSR1_HUMAN
θ value	2.06002e-20 (rank : 270)	NC score	0.881672 (rank : 316)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PHKG1_MOUSE
θ value	2.06002e-20 (rank : 271)	NC score	0.917989 (rank : 162)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	828
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TSSK2_HUMAN
θ value	2.69047e-20 (rank : 272)	NC score	0.911323 (rank : 209)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	818
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

ULK4_MOUSE
θ value	4.58923e-20 (rank : 273)	NC score	0.915684 (rank : 180)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	770
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

CDK4_HUMAN
θ value	5.99374e-20 (rank : 274)	NC score	0.843429 (rank : 425)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	821
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

M3K3_HUMAN
θ value	5.99374e-20 (rank : 275)	NC score	0.898509 (rank : 258)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	844
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

SLK_HUMAN
θ value	5.99374e-20 (rank : 276)	NC score	0.855266 (rank : 386)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1775	Shared Neighborhood Hits	925
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

E2AK2_MOUSE
θ value	7.82807e-20 (rank : 277)	NC score	0.895233 (rank : 272)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	832
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

STK11_HUMAN
θ value	7.82807e-20 (rank : 278)	NC score	0.914507 (rank : 195)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	825
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

CDK4_MOUSE
θ value	1.02238e-19 (rank : 279)	NC score	0.843886 (rank : 423)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

SLK_MOUSE
θ value	1.02238e-19 (rank : 280)	NC score	0.857404 (rank : 379)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1798	Shared Neighborhood Hits	938
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

CAMKV_HUMAN
θ value	1.33526e-19 (rank : 281)	NC score	0.893964 (rank : 277)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1084	Shared Neighborhood Hits	905
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	1.33526e-19 (rank : 282)	NC score	0.894236 (rank : 276)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	801
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

M3K3_MOUSE
θ value	1.33526e-19 (rank : 283)	NC score	0.898625 (rank : 256)
Query Neighborhood Hits	1804	Target Neighborhood Hits	876	Shared Neighborhood Hits	842
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK2_HUMAN
θ value	1.74391e-19 (rank : 284)	NC score	0.903355 (rank : 242)
Query Neighborhood Hits	1804	Target Neighborhood Hits	908	Shared Neighborhood Hits	818
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

ST17B_HUMAN
θ value	1.74391e-19 (rank : 285)	NC score	0.915067 (rank : 189)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MKNK1_MOUSE
θ value	2.27762e-19 (rank : 286)	NC score	0.908311 (rank : 229)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	799
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

CDKL3_MOUSE
θ value	2.97466e-19 (rank : 287)	NC score	0.885065 (rank : 305)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

NEK8_MOUSE
θ value	2.97466e-19 (rank : 288)	NC score	0.889113 (rank : 286)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	831
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK10_HUMAN
θ value	2.97466e-19 (rank : 289)	NC score	0.842141 (rank : 434)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1921	Shared Neighborhood Hits	998
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

NEK8_HUMAN
θ value	3.88503e-19 (rank : 290)	NC score	0.888985 (rank : 288)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

STK24_HUMAN
θ value	3.88503e-19 (rank : 291)	NC score	0.881991 (rank : 314)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

CDKL3_HUMAN
θ value	6.62687e-19 (rank : 292)	NC score	0.883433 (rank : 311)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	829
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

KS6C1_HUMAN
θ value	6.62687e-19 (rank : 293)	NC score	0.830868 (rank : 481)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	640
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

STK10_MOUSE
θ value	8.65492e-19 (rank : 294)	NC score	0.819286 (rank : 512)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2132	Shared Neighborhood Hits	997
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

YSK4_HUMAN
θ value	8.65492e-19 (rank : 295)	NC score	0.882595 (rank : 313)
Query Neighborhood Hits	1804	Target Neighborhood Hits	921	Shared Neighborhood Hits	845
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CDK2_HUMAN
θ value	1.13037e-18 (rank : 296)	NC score	0.864521 (rank : 362)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

M3K15_HUMAN
θ value	1.13037e-18 (rank : 297)	NC score	0.887200 (rank : 297)
Query Neighborhood Hits	1804	Target Neighborhood Hits	914	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

TSSK1_MOUSE
θ value	1.13037e-18 (rank : 298)	NC score	0.908164 (rank : 230)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MP2K3_MOUSE
θ value	1.47631e-18 (rank : 299)	NC score	0.879958 (rank : 325)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TSSK2_MOUSE
θ value	1.47631e-18 (rank : 300)	NC score	0.908599 (rank : 226)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	808
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

CDK7_HUMAN
θ value	1.92812e-18 (rank : 301)	NC score	0.864231 (rank : 363)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	1.92812e-18 (rank : 302)	NC score	0.864536 (rank : 361)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

M4K5_HUMAN
θ value	2.5182e-18 (rank : 303)	NC score	0.867161 (rank : 357)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	828
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MAPK2_MOUSE
θ value	2.5182e-18 (rank : 304)	NC score	0.910464 (rank : 216)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

SBK1_MOUSE
θ value	2.5182e-18 (rank : 305)	NC score	0.919938 (rank : 146)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	808
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

STK25_HUMAN
θ value	2.5182e-18 (rank : 306)	NC score	0.881118 (rank : 320)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	834
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK39_HUMAN
θ value	2.5182e-18 (rank : 307)	NC score	0.881219 (rank : 318)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	844
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	2.5182e-18 (rank : 308)	NC score	0.881422 (rank : 317)
Query Neighborhood Hits	1804	Target Neighborhood Hits	915	Shared Neighborhood Hits	854
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

M4K5_MOUSE
θ value	3.28887e-18 (rank : 309)	NC score	0.868685 (rank : 352)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

NEK11_MOUSE
θ value	3.28887e-18 (rank : 310)	NC score	0.893829 (rank : 278)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PFTK1_MOUSE
θ value	3.28887e-18 (rank : 311)	NC score	0.861034 (rank : 370)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	819
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

STK24_MOUSE
θ value	3.28887e-18 (rank : 312)	NC score	0.880837 (rank : 323)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	837
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

M3K2_HUMAN
θ value	4.29542e-18 (rank : 313)	NC score	0.897946 (rank : 261)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MP2K3_HUMAN
θ value	4.29542e-18 (rank : 314)	NC score	0.877984 (rank : 329)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PFTK1_HUMAN
θ value	4.29542e-18 (rank : 315)	NC score	0.860700 (rank : 371)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

STK25_MOUSE
θ value	4.29542e-18 (rank : 316)	NC score	0.880508 (rank : 324)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NEK2_MOUSE
θ value	5.60996e-18 (rank : 317)	NC score	0.903846 (rank : 238)
Query Neighborhood Hits	1804	Target Neighborhood Hits	876	Shared Neighborhood Hits	820
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

DUET_HUMAN
θ value	7.32683e-18 (rank : 318)	NC score	0.830821 (rank : 482)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1220	Shared Neighborhood Hits	846
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

M3K2_MOUSE
θ value	7.32683e-18 (rank : 319)	NC score	0.897814 (rank : 262)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	827
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

CDKL4_MOUSE
θ value	9.56915e-18 (rank : 320)	NC score	0.871258 (rank : 348)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

M3K14_HUMAN
θ value	1.24977e-17 (rank : 321)	NC score	0.902517 (rank : 243)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MAPK2_HUMAN
θ value	1.24977e-17 (rank : 322)	NC score	0.911251 (rank : 212)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

SBK1_HUMAN
θ value	1.24977e-17 (rank : 323)	NC score	0.918438 (rank : 159)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	810
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MST4_HUMAN
θ value	1.63225e-17 (rank : 324)	NC score	0.880947 (rank : 322)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	834
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	1.63225e-17 (rank : 325)	NC score	0.880950 (rank : 321)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

M3K5_HUMAN
θ value	2.13179e-17 (rank : 326)	NC score	0.890228 (rank : 285)
Query Neighborhood Hits	1804	Target Neighborhood Hits	868	Shared Neighborhood Hits	830
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	2.13179e-17 (rank : 327)	NC score	0.890439 (rank : 284)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

STK40_MOUSE
θ value	2.7842e-17 (rank : 328)	NC score	0.888193 (rank : 293)
Query Neighborhood Hits	1804	Target Neighborhood Hits	751	Shared Neighborhood Hits	740
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CDKL1_HUMAN
θ value	3.63628e-17 (rank : 329)	NC score	0.870860 (rank : 349)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

M3K14_MOUSE
θ value	3.63628e-17 (rank : 330)	NC score	0.895531 (rank : 270)
Query Neighborhood Hits	1804	Target Neighborhood Hits	889	Shared Neighborhood Hits	828
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K6_HUMAN
θ value	3.63628e-17 (rank : 331)	NC score	0.893369 (rank : 280)
Query Neighborhood Hits	1804	Target Neighborhood Hits	889	Shared Neighborhood Hits	851
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

STK40_HUMAN
θ value	3.63628e-17 (rank : 332)	NC score	0.888471 (rank : 291)
Query Neighborhood Hits	1804	Target Neighborhood Hits	751	Shared Neighborhood Hits	740
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

PASK_MOUSE
θ value	4.74913e-17 (rank : 333)	NC score	0.911011 (rank : 213)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	826
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

LIMK1_MOUSE
θ value	8.10077e-17 (rank : 334)	NC score	0.797822 (rank : 553)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1008	Shared Neighborhood Hits	867
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

M3K4_HUMAN
θ value	8.10077e-17 (rank : 335)	NC score	0.895478 (rank : 271)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

TSSK6_HUMAN
θ value	8.10077e-17 (rank : 336)	NC score	0.906131 (rank : 233)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

M4K2_HUMAN
θ value	1.058e-16 (rank : 337)	NC score	0.874474 (rank : 340)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	1.058e-16 (rank : 338)	NC score	0.874765 (rank : 338)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

CDKL1_MOUSE
θ value	1.38178e-16 (rank : 339)	NC score	0.871467 (rank : 347)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	823
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

KS6C1_MOUSE
θ value	1.38178e-16 (rank : 340)	NC score	0.831148 (rank : 479)
Query Neighborhood Hits	1804	Target Neighborhood Hits	700	Shared Neighborhood Hits	638
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

M3K4_MOUSE
θ value	1.38178e-16 (rank : 341)	NC score	0.894836 (rank : 273)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	849
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MP2K5_MOUSE
θ value	1.38178e-16 (rank : 342)	NC score	0.884063 (rank : 307)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K6_MOUSE
θ value	1.38178e-16 (rank : 343)	NC score	0.868367 (rank : 355)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

LIMK1_HUMAN
θ value	1.80466e-16 (rank : 344)	NC score	0.798042 (rank : 552)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	870
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MP2K6_HUMAN
θ value	2.35696e-16 (rank : 345)	NC score	0.868193 (rank : 356)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	821
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

TSSK6_MOUSE
θ value	2.35696e-16 (rank : 346)	NC score	0.906193 (rank : 232)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	816
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

MYO3B_HUMAN
θ value	3.07829e-16 (rank : 347)	NC score	0.764109 (rank : 579)
Query Neighborhood Hits	1804	Target Neighborhood Hits	923	Shared Neighborhood Hits	839
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

PCTK3_MOUSE
θ value	3.07829e-16 (rank : 348)	NC score	0.857501 (rank : 378)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	823
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDKL4_HUMAN
θ value	4.02038e-16 (rank : 349)	NC score	0.866713 (rank : 359)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	822
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

NLK_HUMAN
θ value	4.02038e-16 (rank : 350)	NC score	0.843118 (rank : 429)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	4.02038e-16 (rank : 351)	NC score	0.843188 (rank : 427)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

CDC2_HUMAN
θ value	5.25075e-16 (rank : 352)	NC score	0.864908 (rank : 360)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	829
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_MOUSE
θ value	5.25075e-16 (rank : 353)	NC score	0.860657 (rank : 372)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	819
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

MK07_MOUSE
θ value	5.25075e-16 (rank : 354)	NC score	0.848408 (rank : 412)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1054	Shared Neighborhood Hits	915
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MKNK2_MOUSE
θ value	5.25075e-16 (rank : 355)	NC score	0.908084 (rank : 231)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	809
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MAPK5_MOUSE
θ value	6.85773e-16 (rank : 356)	NC score	0.896275 (rank : 264)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

PCTK2_HUMAN
θ value	6.85773e-16 (rank : 357)	NC score	0.851053 (rank : 396)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	821
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
θ value	6.85773e-16 (rank : 358)	NC score	0.855095 (rank : 387)
Query Neighborhood Hits	1804	Target Neighborhood Hits	827	Shared Neighborhood Hits	815
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

TAOK1_HUMAN
θ value	6.85773e-16 (rank : 359)	NC score	0.812550 (rank : 532)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1734	Shared Neighborhood Hits	936
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	6.85773e-16 (rank : 360)	NC score	0.812876 (rank : 530)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1720	Shared Neighborhood Hits	932
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

MK09_HUMAN
θ value	8.95645e-16 (rank : 361)	NC score	0.845982 (rank : 417)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MKNK2_HUMAN
θ value	8.95645e-16 (rank : 362)	NC score	0.908398 (rank : 228)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

WNK1_MOUSE
θ value	8.95645e-16 (rank : 363)	NC score	0.839592 (rank : 440)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1179	Shared Neighborhood Hits	883
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

PCTK1_MOUSE
θ value	1.16975e-15 (rank : 364)	NC score	0.855435 (rank : 385)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK2_MOUSE
θ value	1.16975e-15 (rank : 365)	NC score	0.850926 (rank : 397)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

TAOK3_HUMAN
θ value	1.16975e-15 (rank : 366)	NC score	0.822374 (rank : 500)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1494	Shared Neighborhood Hits	898
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

WNK1_HUMAN
θ value	1.16975e-15 (rank : 367)	NC score	0.840571 (rank : 438)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1158	Shared Neighborhood Hits	898
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

M3K13_HUMAN
θ value	1.52774e-15 (rank : 368)	NC score	0.832405 (rank : 472)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MAPK5_HUMAN
θ value	1.52774e-15 (rank : 369)	NC score	0.894256 (rank : 275)
Query Neighborhood Hits	1804	Target Neighborhood Hits	795	Shared Neighborhood Hits	780
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

SPEG_MOUSE
θ value	1.52774e-15 (rank : 370)	NC score	0.830275 (rank : 485)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1149
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TLK2_HUMAN
θ value	1.52774e-15 (rank : 371)	NC score	0.874486 (rank : 339)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1044	Shared Neighborhood Hits	812
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	1.52774e-15 (rank : 372)	NC score	0.872482 (rank : 345)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	816
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

CDKL2_MOUSE
θ value	1.99529e-15 (rank : 373)	NC score	0.874151 (rank : 342)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

MK07_HUMAN
θ value	1.99529e-15 (rank : 374)	NC score	0.847863 (rank : 414)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1087	Shared Neighborhood Hits	942
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MP2K5_HUMAN
θ value	1.99529e-15 (rank : 375)	NC score	0.877932 (rank : 331)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

CDC2_MOUSE
θ value	2.60593e-15 (rank : 376)	NC score	0.863801 (rank : 364)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

GSK3A_HUMAN
θ value	2.60593e-15 (rank : 377)	NC score	0.863729 (rank : 365)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

PCTK1_HUMAN
θ value	2.60593e-15 (rank : 378)	NC score	0.854883 (rank : 389)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	821
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

TAOK3_MOUSE
θ value	2.60593e-15 (rank : 379)	NC score	0.824838 (rank : 497)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1458	Shared Neighborhood Hits	887
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

E2AK2_HUMAN
θ value	3.40345e-15 (rank : 380)	NC score	0.877115 (rank : 332)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	823
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

IKKE_HUMAN
θ value	3.40345e-15 (rank : 381)	NC score	0.883123 (rank : 312)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	809
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MYO3A_MOUSE
θ value	3.40345e-15 (rank : 382)	NC score	0.773837 (rank : 573)
Query Neighborhood Hits	1804	Target Neighborhood Hits	902	Shared Neighborhood Hits	830
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PIM1_MOUSE
θ value	3.40345e-15 (rank : 383)	NC score	0.891164 (rank : 283)
Query Neighborhood Hits	1804	Target Neighborhood Hits	787	Shared Neighborhood Hits	781
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_MOUSE
θ value	3.40345e-15 (rank : 384)	NC score	0.900134 (rank : 250)
Query Neighborhood Hits	1804	Target Neighborhood Hits	809	Shared Neighborhood Hits	798
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

RPKL1_HUMAN
θ value	3.40345e-15 (rank : 385)	NC score	0.842770 (rank : 432)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	665
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

CCRK_HUMAN
θ value	4.44505e-15 (rank : 386)	NC score	0.856163 (rank : 382)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CCRK_MOUSE
θ value	4.44505e-15 (rank : 387)	NC score	0.854997 (rank : 388)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

RPKL1_MOUSE
θ value	4.44505e-15 (rank : 388)	NC score	0.844536 (rank : 421)
Query Neighborhood Hits	1804	Target Neighborhood Hits	704	Shared Neighborhood Hits	672
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

WNK3_HUMAN
θ value	4.44505e-15 (rank : 389)	NC score	0.847692 (rank : 415)
Query Neighborhood Hits	1804	Target Neighborhood Hits	948	Shared Neighborhood Hits	802
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

CDK3_MOUSE
θ value	5.8054e-15 (rank : 390)	NC score	0.868573 (rank : 353)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

MP2K4_HUMAN
θ value	5.8054e-15 (rank : 391)	NC score	0.875326 (rank : 335)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	5.8054e-15 (rank : 392)	NC score	0.875078 (rank : 336)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MYO3A_HUMAN
θ value	5.8054e-15 (rank : 393)	NC score	0.765709 (rank : 577)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1033	Shared Neighborhood Hits	848
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

STK35_HUMAN
θ value	5.8054e-15 (rank : 394)	NC score	0.884750 (rank : 306)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	814
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TAOK2_HUMAN
θ value	5.8054e-15 (rank : 395)	NC score	0.844763 (rank : 420)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1172	Shared Neighborhood Hits	868
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	5.8054e-15 (rank : 396)	NC score	0.832713 (rank : 469)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1373	Shared Neighborhood Hits	889
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

MK15_HUMAN
θ value	7.58209e-15 (rank : 397)	NC score	0.859174 (rank : 373)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1038	Shared Neighborhood Hits	932
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CDKL2_HUMAN
θ value	9.90251e-15 (rank : 398)	NC score	0.872602 (rank : 344)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

DYRK2_HUMAN
θ value	1.29331e-14 (rank : 399)	NC score	0.843550 (rank : 424)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

MP2K7_HUMAN
θ value	1.29331e-14 (rank : 400)	NC score	0.885846 (rank : 299)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

PIM2_HUMAN
θ value	1.29331e-14 (rank : 401)	NC score	0.897984 (rank : 260)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	800
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

TITIN_HUMAN
θ value	1.29331e-14 (rank : 402)	NC score	0.705786 (rank : 630)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1098
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

SPEG_HUMAN
θ value	1.68911e-14 (rank : 403)	NC score	0.831260 (rank : 477)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1083
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GSK3B_HUMAN
θ value	2.20605e-14 (rank : 404)	NC score	0.861562 (rank : 367)
Query Neighborhood Hits	1804	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	2.20605e-14 (rank : 405)	NC score	0.861537 (rank : 368)
Query Neighborhood Hits	1804	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

M3K7_MOUSE
θ value	2.20605e-14 (rank : 406)	NC score	0.819397 (rank : 511)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K8_MOUSE
θ value	2.20605e-14 (rank : 407)	NC score	0.875776 (rank : 333)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	798
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MK10_MOUSE
θ value	2.20605e-14 (rank : 408)	NC score	0.836703 (rank : 453)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

M3K8_HUMAN
θ value	2.88119e-14 (rank : 409)	NC score	0.874987 (rank : 337)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MK03_HUMAN
θ value	2.88119e-14 (rank : 410)	NC score	0.838414 (rank : 446)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

PIM1_HUMAN
θ value	2.88119e-14 (rank : 411)	NC score	0.889041 (rank : 287)
Query Neighborhood Hits	1804	Target Neighborhood Hits	797	Shared Neighborhood Hits	791
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

RIPK1_HUMAN
θ value	2.88119e-14 (rank : 412)	NC score	0.825890 (rank : 496)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TLK1_HUMAN
θ value	2.88119e-14 (rank : 413)	NC score	0.874206 (rank : 341)
Query Neighborhood Hits	1804	Target Neighborhood Hits	967	Shared Neighborhood Hits	786
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	2.88119e-14 (rank : 414)	NC score	0.874135 (rank : 343)
Query Neighborhood Hits	1804	Target Neighborhood Hits	947	Shared Neighborhood Hits	789
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

NEK9_HUMAN
θ value	3.76295e-14 (rank : 415)	NC score	0.878351 (rank : 328)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	842
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	3.76295e-14 (rank : 416)	NC score	0.879421 (rank : 326)
Query Neighborhood Hits	1804	Target Neighborhood Hits	890	Shared Neighborhood Hits	836
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

PASK_HUMAN
θ value	3.76295e-14 (rank : 417)	NC score	0.901479 (rank : 245)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	819
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

DYRK3_HUMAN
θ value	4.91457e-14 (rank : 418)	NC score	0.838635 (rank : 445)
Query Neighborhood Hits	1804	Target Neighborhood Hits	798	Shared Neighborhood Hits	785
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

M3K10_HUMAN
θ value	4.91457e-14 (rank : 419)	NC score	0.805147 (rank : 542)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1071	Shared Neighborhood Hits	853
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MK03_MOUSE
θ value	4.91457e-14 (rank : 420)	NC score	0.837903 (rank : 448)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

TNIK_HUMAN
θ value	4.91457e-14 (rank : 421)	NC score	0.849652 (rank : 403)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1570	Shared Neighborhood Hits	953
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

M3K12_HUMAN
θ value	6.41864e-14 (rank : 422)	NC score	0.821018 (rank : 504)
Query Neighborhood Hits	1804	Target Neighborhood Hits	940	Shared Neighborhood Hits	864
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	6.41864e-14 (rank : 423)	NC score	0.821080 (rank : 503)
Query Neighborhood Hits	1804	Target Neighborhood Hits	957	Shared Neighborhood Hits	862
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K7_HUMAN
θ value	6.41864e-14 (rank : 424)	NC score	0.819130 (rank : 513)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MAK_MOUSE
θ value	6.41864e-14 (rank : 425)	NC score	0.856659 (rank : 381)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	843
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

TBK1_HUMAN
θ value	6.41864e-14 (rank : 426)	NC score	0.885419 (rank : 302)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

AL2S7_HUMAN
θ value	8.38298e-14 (rank : 427)	NC score	0.845419 (rank : 419)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	820
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CD2L7_HUMAN
θ value	8.38298e-14 (rank : 428)	NC score	0.852106 (rank : 395)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1275	Shared Neighborhood Hits	983
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

M4K1_MOUSE
θ value	8.38298e-14 (rank : 429)	NC score	0.868428 (rank : 354)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	833
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K4_HUMAN
θ value	8.38298e-14 (rank : 430)	NC score	0.835974 (rank : 454)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1589	Shared Neighborhood Hits	921
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MINK1_HUMAN
θ value	8.38298e-14 (rank : 431)	NC score	0.849368 (rank : 405)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1477	Shared Neighborhood Hits	944
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	8.38298e-14 (rank : 432)	NC score	0.849188 (rank : 408)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1451	Shared Neighborhood Hits	921
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

HIPK1_HUMAN
θ value	1.09485e-13 (rank : 433)	NC score	0.819573 (rank : 509)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	801
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	1.09485e-13 (rank : 434)	NC score	0.819425 (rank : 510)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	800
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

ICK_HUMAN
θ value	1.09485e-13 (rank : 435)	NC score	0.857354 (rank : 380)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TRIB3_MOUSE
θ value	1.09485e-13 (rank : 436)	NC score	0.799703 (rank : 548)
Query Neighborhood Hits	1804	Target Neighborhood Hits	578	Shared Neighborhood Hits	573
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

HIPK3_HUMAN
θ value	1.42992e-13 (rank : 437)	NC score	0.820266 (rank : 508)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	807
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	1.42992e-13 (rank : 438)	NC score	0.821890 (rank : 502)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

ICK_MOUSE
θ value	1.42992e-13 (rank : 439)	NC score	0.858321 (rank : 375)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	831
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MK08_HUMAN
θ value	1.42992e-13 (rank : 440)	NC score	0.839416 (rank : 443)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	1.42992e-13 (rank : 441)	NC score	0.840041 (rank : 439)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_MOUSE
θ value	1.42992e-13 (rank : 442)	NC score	0.840945 (rank : 437)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	826
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK10_HUMAN
θ value	1.42992e-13 (rank : 443)	NC score	0.837002 (rank : 451)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MUC1_HUMAN
θ value	1.42992e-13 (rank : 444)	NC score	0.114271 (rank : 868)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	407
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

TBK1_MOUSE
θ value	1.42992e-13 (rank : 445)	NC score	0.885338 (rank : 303)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	802
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

MAK_HUMAN
θ value	1.86753e-13 (rank : 446)	NC score	0.854766 (rank : 390)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	833
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PIM3_HUMAN
θ value	1.86753e-13 (rank : 447)	NC score	0.892668 (rank : 281)
Query Neighborhood Hits	1804	Target Neighborhood Hits	789	Shared Neighborhood Hits	784
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

HIPK2_HUMAN
θ value	2.43908e-13 (rank : 448)	NC score	0.817943 (rank : 519)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	791
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	2.43908e-13 (rank : 449)	NC score	0.817985 (rank : 517)
Query Neighborhood Hits	1804	Target Neighborhood Hits	871	Shared Neighborhood Hits	802
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

M4K1_HUMAN
θ value	2.43908e-13 (rank : 450)	NC score	0.869232 (rank : 351)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MK12_MOUSE
θ value	2.43908e-13 (rank : 451)	NC score	0.850511 (rank : 399)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PIM3_MOUSE
θ value	2.43908e-13 (rank : 452)	NC score	0.891766 (rank : 282)
Query Neighborhood Hits	1804	Target Neighborhood Hits	783	Shared Neighborhood Hits	778
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CDK5_HUMAN
θ value	3.18553e-13 (rank : 453)	NC score	0.849357 (rank : 406)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

M3K1_MOUSE
θ value	3.18553e-13 (rank : 454)	NC score	0.896483 (rank : 263)
Query Neighborhood Hits	1804	Target Neighborhood Hits	952	Shared Neighborhood Hits	864
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MK12_HUMAN
θ value	3.18553e-13 (rank : 455)	NC score	0.849920 (rank : 400)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CDK5_MOUSE
θ value	4.16044e-13 (rank : 456)	NC score	0.849207 (rank : 407)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

LIMK2_HUMAN
θ value	4.16044e-13 (rank : 457)	NC score	0.803328 (rank : 543)
Query Neighborhood Hits	1804	Target Neighborhood Hits	986	Shared Neighborhood Hits	862
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TRIB1_HUMAN
θ value	4.16044e-13 (rank : 458)	NC score	0.811029 (rank : 535)
Query Neighborhood Hits	1804	Target Neighborhood Hits	598	Shared Neighborhood Hits	583
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

CDK9_HUMAN
θ value	5.43371e-13 (rank : 459)	NC score	0.833841 (rank : 464)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

MK13_HUMAN
θ value	5.43371e-13 (rank : 460)	NC score	0.844479 (rank : 422)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	824
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_MOUSE
θ value	5.43371e-13 (rank : 461)	NC score	0.846069 (rank : 416)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_MOUSE
θ value	5.43371e-13 (rank : 462)	NC score	0.849170 (rank : 409)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	826
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

ANKK1_MOUSE
θ value	7.09661e-13 (rank : 463)	NC score	0.645424 (rank : 743)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1072	Shared Neighborhood Hits	806
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

CD2L5_HUMAN
θ value	7.09661e-13 (rank : 464)	NC score	0.848913 (rank : 410)
Query Neighborhood Hits	1804	Target Neighborhood Hits	987	Shared Neighborhood Hits	872
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	7.09661e-13 (rank : 465)	NC score	0.849686 (rank : 401)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1011	Shared Neighborhood Hits	889
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

IKKB_HUMAN
θ value	9.26847e-13 (rank : 466)	NC score	0.885236 (rank : 304)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	841
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

M3K9_HUMAN
θ value	9.26847e-13 (rank : 467)	NC score	0.805314 (rank : 541)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	880
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MK14_HUMAN
θ value	9.26847e-13 (rank : 468)	NC score	0.848279 (rank : 413)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	826
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

TTK_MOUSE
θ value	9.26847e-13 (rank : 469)	NC score	0.877969 (rank : 330)
Query Neighborhood Hits	1804	Target Neighborhood Hits	803	Shared Neighborhood Hits	764
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

CDK10_HUMAN
θ value	1.2105e-12 (rank : 470)	NC score	0.838263 (rank : 447)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	824
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

MK01_HUMAN
θ value	1.2105e-12 (rank : 471)	NC score	0.834350 (rank : 460)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

RIPK1_MOUSE
θ value	1.2105e-12 (rank : 472)	NC score	0.820389 (rank : 507)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TRIB2_HUMAN
θ value	1.2105e-12 (rank : 473)	NC score	0.834892 (rank : 456)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	652
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

CDK9_MOUSE
θ value	1.58096e-12 (rank : 474)	NC score	0.832998 (rank : 466)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

MK01_MOUSE
θ value	1.58096e-12 (rank : 475)	NC score	0.834080 (rank : 461)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

TRIB2_MOUSE
θ value	1.58096e-12 (rank : 476)	NC score	0.834421 (rank : 459)
Query Neighborhood Hits	1804	Target Neighborhood Hits	653	Shared Neighborhood Hits	648
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

IKKE_MOUSE
θ value	2.0648e-12 (rank : 477)	NC score	0.875634 (rank : 334)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	811
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

LIMK2_MOUSE
θ value	2.0648e-12 (rank : 478)	NC score	0.800207 (rank : 547)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	861
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MK11_MOUSE
θ value	2.69671e-12 (rank : 479)	NC score	0.842991 (rank : 430)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MKNK1_HUMAN
θ value	2.69671e-12 (rank : 480)	NC score	0.866779 (rank : 358)
Query Neighborhood Hits	1804	Target Neighborhood Hits	701	Shared Neighborhood Hits	690
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

CD2L1_HUMAN
θ value	3.52202e-12 (rank : 481)	NC score	0.828540 (rank : 490)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1467	Shared Neighborhood Hits	915
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

IKKA_HUMAN
θ value	3.52202e-12 (rank : 482)	NC score	0.886900 (rank : 298)
Query Neighborhood Hits	1804	Target Neighborhood Hits	863	Shared Neighborhood Hits	829
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	4.59992e-12 (rank : 483)	NC score	0.888541 (rank : 290)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	829
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

M3K11_HUMAN
θ value	4.59992e-12 (rank : 484)	NC score	0.808670 (rank : 537)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1136	Shared Neighborhood Hits	911
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MK15_MOUSE
θ value	4.59992e-12 (rank : 485)	NC score	0.855506 (rank : 384)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

TRIB3_HUMAN
θ value	4.59992e-12 (rank : 486)	NC score	0.780422 (rank : 568)
Query Neighborhood Hits	1804	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TXK_HUMAN
θ value	4.59992e-12 (rank : 487)	NC score	0.719869 (rank : 611)
Query Neighborhood Hits	1804	Target Neighborhood Hits	971	Shared Neighborhood Hits	820
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CD2L2_HUMAN
θ value	6.00763e-12 (rank : 488)	NC score	0.831254 (rank : 478)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1439	Shared Neighborhood Hits	920
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

TRIB1_MOUSE
θ value	6.00763e-12 (rank : 489)	NC score	0.806844 (rank : 539)
Query Neighborhood Hits	1804	Target Neighborhood Hits	593	Shared Neighborhood Hits	586
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

CD2L1_MOUSE
θ value	7.84624e-12 (rank : 490)	NC score	0.828037 (rank : 492)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1463	Shared Neighborhood Hits	919
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

IKKB_MOUSE
θ value	7.84624e-12 (rank : 491)	NC score	0.883950 (rank : 308)
Query Neighborhood Hits	1804	Target Neighborhood Hits	984	Shared Neighborhood Hits	836
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MK11_HUMAN
θ value	7.84624e-12 (rank : 492)	NC score	0.834806 (rank : 458)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

TTK_HUMAN
θ value	7.84624e-12 (rank : 493)	NC score	0.879396 (rank : 327)
Query Neighborhood Hits	1804	Target Neighborhood Hits	816	Shared Neighborhood Hits	780
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

M4K4_MOUSE
θ value	1.02475e-11 (rank : 494)	NC score	0.828516 (rank : 491)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1560	Shared Neighborhood Hits	933
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TESK1_MOUSE
θ value	1.02475e-11 (rank : 495)	NC score	0.817718 (rank : 520)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	819
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

CLK2_HUMAN
θ value	1.33837e-11 (rank : 496)	NC score	0.788793 (rank : 563)
Query Neighborhood Hits	1804	Target Neighborhood Hits	752	Shared Neighborhood Hits	736
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MK06_MOUSE
θ value	1.33837e-11 (rank : 497)	NC score	0.823067 (rank : 499)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	795
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

RIPK2_MOUSE
θ value	1.33837e-11 (rank : 498)	NC score	0.774806 (rank : 572)
Query Neighborhood Hits	1804	Target Neighborhood Hits	776	Shared Neighborhood Hits	752
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK4_HUMAN
θ value	1.33837e-11 (rank : 499)	NC score	0.633941 (rank : 758)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1094	Shared Neighborhood Hits	814
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

TESK1_HUMAN
θ value	1.33837e-11 (rank : 500)	NC score	0.816237 (rank : 523)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	821
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

NRK_HUMAN
θ value	1.74796e-11 (rank : 501)	NC score	0.855634 (rank : 383)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	852
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PRG4_MOUSE
θ value	1.74796e-11 (rank : 502)	NC score	0.078205 (rank : 935)
Query Neighborhood Hits	1804	Target Neighborhood Hits	624	Shared Neighborhood Hits	225
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PDK1L_HUMAN
θ value	2.28291e-11 (rank : 503)	NC score	0.887840 (rank : 294)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	2.28291e-11 (rank : 504)	NC score	0.887501 (rank : 296)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

CLK1_HUMAN
θ value	2.98157e-11 (rank : 505)	NC score	0.796020 (rank : 558)
Query Neighborhood Hits	1804	Target Neighborhood Hits	756	Shared Neighborhood Hits	741
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

MK06_HUMAN
θ value	2.98157e-11 (rank : 506)	NC score	0.823357 (rank : 498)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	795
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

PMYT1_HUMAN
θ value	2.98157e-11 (rank : 507)	NC score	0.883593 (rank : 310)
Query Neighborhood Hits	1804	Target Neighborhood Hits	814	Shared Neighborhood Hits	804
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

RIPK2_HUMAN
θ value	2.98157e-11 (rank : 508)	NC score	0.772399 (rank : 575)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	752
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TESK2_MOUSE
θ value	2.98157e-11 (rank : 509)	NC score	0.816094 (rank : 524)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	809
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

WNK2_HUMAN
θ value	2.98157e-11 (rank : 510)	NC score	0.830025 (rank : 486)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1407	Shared Neighborhood Hits	979
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ANKK1_HUMAN
θ value	3.89403e-11 (rank : 511)	NC score	0.629843 (rank : 761)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1075	Shared Neighborhood Hits	802
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

FES_MOUSE
θ value	3.89403e-11 (rank : 512)	NC score	0.744763 (rank : 590)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	818
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PRP4B_HUMAN
θ value	3.89403e-11 (rank : 513)	NC score	0.811534 (rank : 534)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1030	Shared Neighborhood Hits	841
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	3.89403e-11 (rank : 514)	NC score	0.809321 (rank : 536)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1040	Shared Neighborhood Hits	842
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

CLK2_MOUSE
θ value	5.08577e-11 (rank : 515)	NC score	0.774864 (rank : 571)
Query Neighborhood Hits	1804	Target Neighborhood Hits	743	Shared Neighborhood Hits	730
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

GAK_HUMAN
θ value	5.08577e-11 (rank : 516)	NC score	0.820821 (rank : 505)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1028	Shared Neighborhood Hits	887
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PMYT1_MOUSE
θ value	5.08577e-11 (rank : 517)	NC score	0.888869 (rank : 289)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	867
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

RIPK3_MOUSE
θ value	5.08577e-11 (rank : 518)	NC score	0.815901 (rank : 525)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	821
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

TESK2_HUMAN
θ value	5.08577e-11 (rank : 519)	NC score	0.816470 (rank : 521)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	821
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ABL2_HUMAN
θ value	6.64225e-11 (rank : 520)	NC score	0.712539 (rank : 619)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1045	Shared Neighborhood Hits	843
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CLK1_MOUSE
θ value	6.64225e-11 (rank : 521)	NC score	0.794017 (rank : 561)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	751
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

FES_HUMAN
θ value	8.67504e-11 (rank : 522)	NC score	0.743702 (rank : 591)
Query Neighborhood Hits	1804	Target Neighborhood Hits	978	Shared Neighborhood Hits	809
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MUSK_HUMAN
θ value	8.67504e-11 (rank : 523)	NC score	0.608190 (rank : 788)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1074	Shared Neighborhood Hits	789
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	8.67504e-11 (rank : 524)	NC score	0.604222 (rank : 793)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1057	Shared Neighborhood Hits	785
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

GAK_MOUSE
θ value	1.133e-10 (rank : 525)	NC score	0.815393 (rank : 526)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	844
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

RIPK3_HUMAN
θ value	1.133e-10 (rank : 526)	NC score	0.808451 (rank : 538)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	808
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

M3KL4_HUMAN
θ value	1.47974e-10 (rank : 527)	NC score	0.786829 (rank : 565)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1087	Shared Neighborhood Hits	850
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

TNI3K_MOUSE
θ value	1.47974e-10 (rank : 528)	NC score	0.709340 (rank : 625)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1079	Shared Neighborhood Hits	804
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

E2AK4_MOUSE
θ value	1.9326e-10 (rank : 529)	NC score	0.850601 (rank : 398)
Query Neighborhood Hits	1804	Target Neighborhood Hits	984	Shared Neighborhood Hits	854
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

ERN1_HUMAN
θ value	1.9326e-10 (rank : 530)	NC score	0.841592 (rank : 435)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	811
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK04_MOUSE
θ value	1.9326e-10 (rank : 531)	NC score	0.830434 (rank : 483)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	814
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

PTK6_HUMAN
θ value	1.9326e-10 (rank : 532)	NC score	0.731670 (rank : 599)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	842
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

FER_HUMAN
θ value	2.52405e-10 (rank : 533)	NC score	0.725114 (rank : 606)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1278	Shared Neighborhood Hits	841
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

SRRM2_HUMAN
θ value	2.52405e-10 (rank : 534)	NC score	0.123995 (rank : 863)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1296	Shared Neighborhood Hits	472
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PRG4_HUMAN
θ value	3.29651e-10 (rank : 535)	NC score	0.082344 (rank : 924)
Query Neighborhood Hits	1804	Target Neighborhood Hits	764	Shared Neighborhood Hits	262
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ABL1_HUMAN
θ value	4.30538e-10 (rank : 536)	NC score	0.715365 (rank : 615)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1220	Shared Neighborhood Hits	930
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

E2AK4_HUMAN
θ value	4.30538e-10 (rank : 537)	NC score	0.852939 (rank : 392)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1012	Shared Neighborhood Hits	859
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

JAK3_MOUSE
θ value	4.30538e-10 (rank : 538)	NC score	0.773231 (rank : 574)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	805
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

PTK7_HUMAN
θ value	4.30538e-10 (rank : 539)	NC score	0.624044 (rank : 769)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	782
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

WNK4_MOUSE
θ value	4.30538e-10 (rank : 540)	NC score	0.834029 (rank : 462)
Query Neighborhood Hits	1804	Target Neighborhood Hits	961	Shared Neighborhood Hits	828
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ABL1_MOUSE
θ value	5.62301e-10 (rank : 541)	NC score	0.717044 (rank : 612)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1178	Shared Neighborhood Hits	920
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ERBB2_HUMAN
θ value	5.62301e-10 (rank : 542)	NC score	0.675105 (rank : 677)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1073	Shared Neighborhood Hits	884
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

JAK3_HUMAN
θ value	5.62301e-10 (rank : 543)	NC score	0.764843 (rank : 578)
Query Neighborhood Hits	1804	Target Neighborhood Hits	827	Shared Neighborhood Hits	812
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

MK04_HUMAN
θ value	5.62301e-10 (rank : 544)	NC score	0.832533 (rank : 471)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

TNI3K_HUMAN
θ value	5.62301e-10 (rank : 545)	NC score	0.701241 (rank : 636)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1084	Shared Neighborhood Hits	809
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

WNK4_HUMAN
θ value	5.62301e-10 (rank : 546)	NC score	0.835299 (rank : 455)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1043	Shared Neighborhood Hits	864
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

FAK2_HUMAN
θ value	7.34386e-10 (rank : 547)	NC score	0.706489 (rank : 629)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	800
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	7.34386e-10 (rank : 548)	NC score	0.711016 (rank : 620)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	803
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ZAP70_MOUSE
θ value	7.34386e-10 (rank : 549)	NC score	0.725815 (rank : 605)
Query Neighborhood Hits	1804	Target Neighborhood Hits	905	Shared Neighborhood Hits	819
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

DDR2_MOUSE
θ value	9.59137e-10 (rank : 550)	NC score	0.662725 (rank : 704)
Query Neighborhood Hits	1804	Target Neighborhood Hits	813	Shared Neighborhood Hits	773
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

LRRK1_MOUSE
θ value	9.59137e-10 (rank : 551)	NC score	0.740290 (rank : 594)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1267	Shared Neighborhood Hits	823
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PTK6_MOUSE
θ value	9.59137e-10 (rank : 552)	NC score	0.732280 (rank : 597)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	842
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ERN1_MOUSE
θ value	1.25267e-09 (rank : 553)	NC score	0.839352 (rank : 444)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	808
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

PDZD1_MOUSE
θ value	1.25267e-09 (rank : 554)	NC score	0.118462 (rank : 864)
Query Neighborhood Hits	1804	Target Neighborhood Hits	191	Shared Neighborhood Hits	120
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

BRAF1_HUMAN
θ value	1.63604e-09 (rank : 555)	NC score	0.799164 (rank : 550)
Query Neighborhood Hits	1804	Target Neighborhood Hits	883	Shared Neighborhood Hits	826
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CLK4_HUMAN
θ value	1.63604e-09 (rank : 556)	NC score	0.785537 (rank : 566)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

DYRK4_HUMAN
θ value	1.63604e-09 (rank : 557)	NC score	0.811834 (rank : 533)
Query Neighborhood Hits	1804	Target Neighborhood Hits	750	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

LYN_HUMAN
θ value	1.63604e-09 (rank : 558)	NC score	0.706859 (rank : 628)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1022	Shared Neighborhood Hits	846
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NFH_HUMAN
θ value	1.63604e-09 (rank : 559)	NC score	0.038920 (rank : 1229)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1242	Shared Neighborhood Hits	301
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PCLO_MOUSE
θ value	1.63604e-09 (rank : 560)	NC score	0.115643 (rank : 866)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2275	Shared Neighborhood Hits	705
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PDZD1_HUMAN
θ value	1.63604e-09 (rank : 561)	NC score	0.114270 (rank : 869)
Query Neighborhood Hits	1804	Target Neighborhood Hits	190	Shared Neighborhood Hits	120
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

DYR1B_MOUSE
θ value	2.13673e-09 (rank : 562)	NC score	0.829677 (rank : 487)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

EGFR_MOUSE
θ value	2.13673e-09 (rank : 563)	NC score	0.686456 (rank : 654)
Query Neighborhood Hits	1804	Target Neighborhood Hits	927	Shared Neighborhood Hits	814
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

NCOR2_HUMAN
θ value	2.13673e-09 (rank : 564)	NC score	0.082031 (rank : 926)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	308
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

CD2L6_HUMAN
θ value	2.79066e-09 (rank : 565)	NC score	0.817966 (rank : 518)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	2.79066e-09 (rank : 566)	NC score	0.818286 (rank : 516)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CLK4_MOUSE
θ value	2.79066e-09 (rank : 567)	NC score	0.783244 (rank : 567)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	750
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

LYN_MOUSE
θ value	2.79066e-09 (rank : 568)	NC score	0.707004 (rank : 627)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	848
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

DYR1A_HUMAN
θ value	3.64472e-09 (rank : 569)	NC score	0.818801 (rank : 514)
Query Neighborhood Hits	1804	Target Neighborhood Hits	764	Shared Neighborhood Hits	750
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	3.64472e-09 (rank : 570)	NC score	0.818799 (rank : 515)
Query Neighborhood Hits	1804	Target Neighborhood Hits	762	Shared Neighborhood Hits	750
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

ERBB2_MOUSE
θ value	3.64472e-09 (rank : 571)	NC score	0.677238 (rank : 676)
Query Neighborhood Hits	1804	Target Neighborhood Hits	918	Shared Neighborhood Hits	824
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

JAK1_HUMAN
θ value	3.64472e-09 (rank : 572)	NC score	0.743033 (rank : 593)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	822
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MLTK_MOUSE
θ value	3.64472e-09 (rank : 573)	NC score	0.797465 (rank : 555)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	825
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

CLK3_HUMAN
θ value	4.76016e-09 (rank : 574)	NC score	0.760824 (rank : 581)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	731
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	4.76016e-09 (rank : 575)	NC score	0.760189 (rank : 582)
Query Neighborhood Hits	1804	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

EGFR_HUMAN
θ value	4.76016e-09 (rank : 576)	NC score	0.686042 (rank : 656)
Query Neighborhood Hits	1804	Target Neighborhood Hits	939	Shared Neighborhood Hits	814
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

IRAK4_HUMAN
θ value	4.76016e-09 (rank : 577)	NC score	0.814326 (rank : 527)
Query Neighborhood Hits	1804	Target Neighborhood Hits	816	Shared Neighborhood Hits	805
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

MLTK_HUMAN
θ value	4.76016e-09 (rank : 578)	NC score	0.797116 (rank : 556)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	837
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

NTRK3_HUMAN
θ value	4.76016e-09 (rank : 579)	NC score	0.652241 (rank : 729)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1115	Shared Neighborhood Hits	797
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TEC_MOUSE
θ value	4.76016e-09 (rank : 580)	NC score	0.727375 (rank : 602)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1006	Shared Neighborhood Hits	830
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

DYR1B_HUMAN
θ value	6.21693e-09 (rank : 581)	NC score	0.829006 (rank : 488)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	792
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

E2AK3_HUMAN
θ value	6.21693e-09 (rank : 582)	NC score	0.852248 (rank : 394)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	832
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	6.21693e-09 (rank : 583)	NC score	0.849669 (rank : 402)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

ROR1_HUMAN
θ value	6.21693e-09 (rank : 584)	NC score	0.664816 (rank : 700)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1018	Shared Neighborhood Hits	812
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ARAF_HUMAN
θ value	8.11959e-09 (rank : 585)	NC score	0.795262 (rank : 559)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	856
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BLK_MOUSE
θ value	8.11959e-09 (rank : 586)	NC score	0.686087 (rank : 655)
Query Neighborhood Hits	1804	Target Neighborhood Hits	992	Shared Neighborhood Hits	836
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CDK8_HUMAN
θ value	8.11959e-09 (rank : 587)	NC score	0.813121 (rank : 529)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

JAK2_HUMAN
θ value	8.11959e-09 (rank : 588)	NC score	0.760879 (rank : 580)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	822
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LRRK1_HUMAN
θ value	8.11959e-09 (rank : 589)	NC score	0.743158 (rank : 592)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1237	Shared Neighborhood Hits	815
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

NACAM_MOUSE
θ value	8.11959e-09 (rank : 590)	NC score	0.135343 (rank : 854)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1866	Shared Neighborhood Hits	630
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NRK_MOUSE
θ value	8.11959e-09 (rank : 591)	NC score	0.852794 (rank : 393)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	849
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

TEC_HUMAN
θ value	8.11959e-09 (rank : 592)	NC score	0.721461 (rank : 608)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1006	Shared Neighborhood Hits	831
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZAP70_HUMAN
θ value	8.11959e-09 (rank : 593)	NC score	0.727544 (rank : 601)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	813
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

E2AK1_HUMAN
θ value	1.06045e-08 (rank : 594)	NC score	0.843390 (rank : 426)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

EPHA5_HUMAN
θ value	1.06045e-08 (rank : 595)	NC score	0.662639 (rank : 705)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	825
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ITK_MOUSE
θ value	1.06045e-08 (rank : 596)	NC score	0.710508 (rank : 623)
Query Neighborhood Hits	1804	Target Neighborhood Hits	985	Shared Neighborhood Hits	830
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

JAK1_MOUSE
θ value	1.06045e-08 (rank : 597)	NC score	0.734297 (rank : 596)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	821
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_MOUSE
θ value	1.06045e-08 (rank : 598)	NC score	0.760015 (rank : 583)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	818
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LCK_MOUSE
θ value	1.06045e-08 (rank : 599)	NC score	0.696305 (rank : 640)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	832
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BMPR2_HUMAN
θ value	1.38499e-08 (rank : 600)	NC score	0.647417 (rank : 740)
Query Neighborhood Hits	1804	Target Neighborhood Hits	736	Shared Neighborhood Hits	708
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

ARAF_MOUSE
θ value	1.80886e-08 (rank : 601)	NC score	0.794431 (rank : 560)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

BMPR2_MOUSE
θ value	1.80886e-08 (rank : 602)	NC score	0.646174 (rank : 742)
Query Neighborhood Hits	1804	Target Neighborhood Hits	738	Shared Neighborhood Hits	710
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

SRRM1_HUMAN
θ value	2.36244e-08 (rank : 603)	NC score	0.112294 (rank : 870)
Query Neighborhood Hits	1804	Target Neighborhood Hits	690	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	2.36244e-08 (rank : 604)	NC score	0.134612 (rank : 856)
Query Neighborhood Hits	1804	Target Neighborhood Hits	966	Shared Neighborhood Hits	423
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

BLK_HUMAN
θ value	3.08544e-08 (rank : 605)	NC score	0.689424 (rank : 650)
Query Neighborhood Hits	1804	Target Neighborhood Hits	994	Shared Neighborhood Hits	834
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYN_HUMAN
θ value	3.08544e-08 (rank : 606)	NC score	0.690674 (rank : 648)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

LRRK2_HUMAN
θ value	3.08544e-08 (rank : 607)	NC score	0.715911 (rank : 614)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1382	Shared Neighborhood Hits	830
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

CSK22_HUMAN
θ value	4.0297e-08 (rank : 608)	NC score	0.837471 (rank : 450)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DDR2_HUMAN
θ value	4.0297e-08 (rank : 609)	NC score	0.656257 (rank : 717)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	774
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ITK_HUMAN
θ value	4.0297e-08 (rank : 610)	NC score	0.710839 (rank : 621)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1016	Shared Neighborhood Hits	830
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

NTRK1_HUMAN
θ value	4.0297e-08 (rank : 611)	NC score	0.651446 (rank : 732)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	789
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	4.0297e-08 (rank : 612)	NC score	0.677929 (rank : 673)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1081	Shared Neighborhood Hits	811
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

TNK1_MOUSE
θ value	4.0297e-08 (rank : 613)	NC score	0.694189 (rank : 647)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	780
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

CSK21_HUMAN
θ value	5.26297e-08 (rank : 614)	NC score	0.841560 (rank : 436)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	766
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	5.26297e-08 (rank : 615)	NC score	0.842209 (rank : 433)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	766
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

EPHA5_MOUSE
θ value	5.26297e-08 (rank : 616)	NC score	0.680593 (rank : 671)
Query Neighborhood Hits	1804	Target Neighborhood Hits	950	Shared Neighborhood Hits	820
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA7_MOUSE
θ value	5.26297e-08 (rank : 617)	NC score	0.665403 (rank : 698)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1025	Shared Neighborhood Hits	825
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

MOK_MOUSE
θ value	5.26297e-08 (rank : 618)	NC score	0.832966 (rank : 467)
Query Neighborhood Hits	1804	Target Neighborhood Hits	796	Shared Neighborhood Hits	792
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

NFH_MOUSE
θ value	5.26297e-08 (rank : 619)	NC score	0.093566 (rank : 902)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2247	Shared Neighborhood Hits	678
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PGFRB_HUMAN
θ value	5.26297e-08 (rank : 620)	NC score	0.609980 (rank : 783)
Query Neighborhood Hits	1804	Target Neighborhood Hits	962	Shared Neighborhood Hits	793
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

BTK_HUMAN
θ value	6.87365e-08 (rank : 621)	NC score	0.710634 (rank : 622)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	828
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	6.87365e-08 (rank : 622)	NC score	0.710247 (rank : 624)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1017	Shared Neighborhood Hits	830
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

EPHA8_HUMAN
θ value	6.87365e-08 (rank : 623)	NC score	0.653389 (rank : 725)
Query Neighborhood Hits	1804	Target Neighborhood Hits	956	Shared Neighborhood Hits	814
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FRK_HUMAN
θ value	6.87365e-08 (rank : 624)	NC score	0.705428 (rank : 631)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	847
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ROR1_MOUSE
θ value	6.87365e-08 (rank : 625)	NC score	0.666395 (rank : 695)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1025	Shared Neighborhood Hits	816
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

CSK22_MOUSE
θ value	8.97725e-08 (rank : 626)	NC score	0.836987 (rank : 452)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

EPHB1_HUMAN
θ value	8.97725e-08 (rank : 627)	NC score	0.671350 (rank : 685)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	819
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

NTRK2_MOUSE
θ value	8.97725e-08 (rank : 628)	NC score	0.677286 (rank : 675)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	811
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

PGFRB_MOUSE
θ value	8.97725e-08 (rank : 629)	NC score	0.608677 (rank : 786)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	792
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

TYK2_HUMAN
θ value	8.97725e-08 (rank : 630)	NC score	0.755355 (rank : 584)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

E2AK1_MOUSE
θ value	1.17247e-07 (rank : 631)	NC score	0.848526 (rank : 411)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

IRAK4_MOUSE
θ value	1.17247e-07 (rank : 632)	NC score	0.820689 (rank : 506)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	805
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

LRRK2_MOUSE
θ value	1.17247e-07 (rank : 633)	NC score	0.695692 (rank : 641)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1359	Shared Neighborhood Hits	821
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

RAF1_HUMAN
θ value	1.17247e-07 (rank : 634)	NC score	0.797785 (rank : 554)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	834
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	1.17247e-07 (rank : 635)	NC score	0.798643 (rank : 551)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

EPHA7_HUMAN
θ value	1.53129e-07 (rank : 636)	NC score	0.664545 (rank : 702)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1053	Shared Neighborhood Hits	830
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FAK1_HUMAN
θ value	1.53129e-07 (rank : 637)	NC score	0.721270 (rank : 609)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	1.53129e-07 (rank : 638)	NC score	0.720959 (rank : 610)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

LCK_HUMAN
θ value	1.53129e-07 (rank : 639)	NC score	0.689986 (rank : 649)
Query Neighborhood Hits	1804	Target Neighborhood Hits	987	Shared Neighborhood Hits	836
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

SYNJ1_MOUSE
θ value	1.53129e-07 (rank : 640)	NC score	0.060020 (rank : 1042)
Query Neighborhood Hits	1804	Target Neighborhood Hits	516	Shared Neighborhood Hits	223
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

KSYK_HUMAN
θ value	1.99992e-07 (rank : 641)	NC score	0.726553 (rank : 603)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	810
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TIE2_MOUSE
θ value	1.99992e-07 (rank : 642)	NC score	0.681963 (rank : 668)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1204	Shared Neighborhood Hits	823
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TYRO3_HUMAN
θ value	1.99992e-07 (rank : 643)	NC score	0.651043 (rank : 733)
Query Neighborhood Hits	1804	Target Neighborhood Hits	995	Shared Neighborhood Hits	779
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHA8_MOUSE
θ value	2.61198e-07 (rank : 644)	NC score	0.647341 (rank : 741)
Query Neighborhood Hits	1804	Target Neighborhood Hits	969	Shared Neighborhood Hits	809
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

ERBB4_HUMAN
θ value	2.61198e-07 (rank : 645)	NC score	0.681583 (rank : 669)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	806
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

HIPK4_HUMAN
θ value	2.61198e-07 (rank : 646)	NC score	0.832633 (rank : 470)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	790
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

KSR1_MOUSE
θ value	2.61198e-07 (rank : 647)	NC score	0.747915 (rank : 587)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	819
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSYK_MOUSE
θ value	2.61198e-07 (rank : 648)	NC score	0.726419 (rank : 604)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	829
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TIE2_HUMAN
θ value	2.61198e-07 (rank : 649)	NC score	0.682773 (rank : 664)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1192	Shared Neighborhood Hits	822
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TXK_MOUSE
θ value	2.61198e-07 (rank : 650)	NC score	0.701787 (rank : 634)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	815
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CSK_MOUSE
θ value	3.41135e-07 (rank : 651)	NC score	0.724952 (rank : 607)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	831
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

EPHA6_MOUSE
θ value	3.41135e-07 (rank : 652)	NC score	0.612150 (rank : 782)
Query Neighborhood Hits	1804	Target Neighborhood Hits	946	Shared Neighborhood Hits	807
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ERN2_HUMAN
θ value	3.41135e-07 (rank : 653)	NC score	0.834828 (rank : 457)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

LTK_MOUSE
θ value	3.41135e-07 (rank : 654)	NC score	0.617860 (rank : 776)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	748
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

SRC_HUMAN
θ value	3.41135e-07 (rank : 655)	NC score	0.681315 (rank : 670)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	843
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TNK1_HUMAN
θ value	3.41135e-07 (rank : 656)	NC score	0.683494 (rank : 662)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	783
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

VGFR3_MOUSE
θ value	3.41135e-07 (rank : 657)	NC score	0.621190 (rank : 772)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	794
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

AFF1_HUMAN
θ value	4.45536e-07 (rank : 658)	NC score	0.067944 (rank : 978)
Query Neighborhood Hits	1804	Target Neighborhood Hits	506	Shared Neighborhood Hits	210
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

BMX_HUMAN
θ value	4.45536e-07 (rank : 659)	NC score	0.713530 (rank : 616)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	808
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

EPHA1_HUMAN
θ value	4.45536e-07 (rank : 660)	NC score	0.652394 (rank : 728)
Query Neighborhood Hits	1804	Target Neighborhood Hits	997	Shared Neighborhood Hits	815
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA4_HUMAN
θ value	4.45536e-07 (rank : 661)	NC score	0.653786 (rank : 723)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	818
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	4.45536e-07 (rank : 662)	NC score	0.653536 (rank : 724)
Query Neighborhood Hits	1804	Target Neighborhood Hits	982	Shared Neighborhood Hits	818
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

MATK_HUMAN
θ value	4.45536e-07 (rank : 663)	NC score	0.705183 (rank : 632)
Query Neighborhood Hits	1804	Target Neighborhood Hits	954	Shared Neighborhood Hits	823
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MOS_HUMAN
θ value	4.45536e-07 (rank : 664)	NC score	0.800944 (rank : 545)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	820
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PSCBP_HUMAN
θ value	4.45536e-07 (rank : 665)	NC score	0.127000 (rank : 860)
Query Neighborhood Hits	1804	Target Neighborhood Hits	123	Shared Neighborhood Hits	101
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

VGFR3_HUMAN
θ value	4.45536e-07 (rank : 666)	NC score	0.617914 (rank : 775)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	794
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

BMP2K_MOUSE
θ value	5.81887e-07 (rank : 667)	NC score	0.826629 (rank : 493)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	792
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CSK_HUMAN
θ value	5.81887e-07 (rank : 668)	NC score	0.716906 (rank : 613)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	830
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DDR1_MOUSE
θ value	5.81887e-07 (rank : 669)	NC score	0.627398 (rank : 763)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	768
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FYB_HUMAN
θ value	5.81887e-07 (rank : 670)	NC score	0.068264 (rank : 975)
Query Neighborhood Hits	1804	Target Neighborhood Hits	379	Shared Neighborhood Hits	182
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

KSR2_HUMAN
θ value	5.81887e-07 (rank : 671)	NC score	0.777780 (rank : 570)
Query Neighborhood Hits	1804	Target Neighborhood Hits	920	Shared Neighborhood Hits	840
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

TYK2_MOUSE
θ value	5.81887e-07 (rank : 672)	NC score	0.748561 (rank : 586)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_MOUSE
θ value	5.81887e-07 (rank : 673)	NC score	0.650265 (rank : 736)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1007	Shared Neighborhood Hits	779
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

PSCBP_MOUSE
θ value	7.59969e-07 (rank : 674)	NC score	0.127897 (rank : 859)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	99
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

SRC_MOUSE
θ value	7.59969e-07 (rank : 675)	NC score	0.682365 (rank : 666)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1033	Shared Neighborhood Hits	832
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

DDR1_HUMAN
θ value	9.92553e-07 (rank : 676)	NC score	0.626268 (rank : 766)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	769
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EPHA3_HUMAN
θ value	9.92553e-07 (rank : 677)	NC score	0.664712 (rank : 701)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	821
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA6_HUMAN
θ value	9.92553e-07 (rank : 678)	NC score	0.607147 (rank : 789)
Query Neighborhood Hits	1804	Target Neighborhood Hits	959	Shared Neighborhood Hits	808
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHB2_HUMAN
θ value	9.92553e-07 (rank : 679)	NC score	0.655759 (rank : 720)
Query Neighborhood Hits	1804	Target Neighborhood Hits	983	Shared Neighborhood Hits	814
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	9.92553e-07 (rank : 680)	NC score	0.655818 (rank : 718)
Query Neighborhood Hits	1804	Target Neighborhood Hits	982	Shared Neighborhood Hits	814
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

SRRM2_MOUSE
θ value	9.92553e-07 (rank : 681)	NC score	0.134214 (rank : 858)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1470	Shared Neighborhood Hits	525
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BMP2K_HUMAN
θ value	1.29631e-06 (rank : 682)	NC score	0.825979 (rank : 495)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	794
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMX_MOUSE
θ value	1.29631e-06 (rank : 683)	NC score	0.712929 (rank : 617)
Query Neighborhood Hits	1804	Target Neighborhood Hits	912	Shared Neighborhood Hits	794
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

CN155_HUMAN
θ value	1.29631e-06 (rank : 684)	NC score	0.069132 (rank : 967)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	150
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CSKI1_MOUSE
θ value	1.29631e-06 (rank : 685)	NC score	0.066569 (rank : 990)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1031	Shared Neighborhood Hits	362
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

EPHB3_HUMAN
θ value	1.29631e-06 (rank : 686)	NC score	0.642970 (rank : 745)
Query Neighborhood Hits	1804	Target Neighborhood Hits	996	Shared Neighborhood Hits	826
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB4_HUMAN
θ value	1.29631e-06 (rank : 687)	NC score	0.657730 (rank : 712)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	818
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	1.29631e-06 (rank : 688)	NC score	0.660496 (rank : 707)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1013	Shared Neighborhood Hits	817
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ERN2_MOUSE
θ value	1.29631e-06 (rank : 689)	NC score	0.833864 (rank : 463)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FGFR2_HUMAN
θ value	1.29631e-06 (rank : 690)	NC score	0.677769 (rank : 674)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1062	Shared Neighborhood Hits	815
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	1.29631e-06 (rank : 691)	NC score	0.679751 (rank : 672)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1062	Shared Neighborhood Hits	817
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR4_HUMAN
θ value	1.29631e-06 (rank : 692)	NC score	0.652929 (rank : 726)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	808
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

MATK_MOUSE
θ value	1.29631e-06 (rank : 693)	NC score	0.709001 (rank : 626)
Query Neighborhood Hits	1804	Target Neighborhood Hits	952	Shared Neighborhood Hits	827
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PINK1_MOUSE
θ value	1.29631e-06 (rank : 694)	NC score	0.788623 (rank : 564)
Query Neighborhood Hits	1804	Target Neighborhood Hits	726	Shared Neighborhood Hits	718
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RET_MOUSE
θ value	1.29631e-06 (rank : 695)	NC score	0.684358 (rank : 661)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	806
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CI096_HUMAN
θ value	1.69304e-06 (rank : 696)	NC score	0.830293 (rank : 484)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	797
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CSKI2_HUMAN
θ value	1.69304e-06 (rank : 697)	NC score	0.056754 (rank : 1070)
Query Neighborhood Hits	1804	Target Neighborhood Hits	747	Shared Neighborhood Hits	234
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

FGFR1_HUMAN
θ value	1.69304e-06 (rank : 698)	NC score	0.674454 (rank : 680)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1069	Shared Neighborhood Hits	821
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.69304e-06 (rank : 699)	NC score	0.674565 (rank : 679)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1068	Shared Neighborhood Hits	820
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR3_HUMAN
θ value	1.69304e-06 (rank : 700)	NC score	0.668585 (rank : 692)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1042	Shared Neighborhood Hits	815
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

MERTK_MOUSE
θ value	1.69304e-06 (rank : 701)	NC score	0.633173 (rank : 759)
Query Neighborhood Hits	1804	Target Neighborhood Hits	974	Shared Neighborhood Hits	769
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MLL2_HUMAN
θ value	1.69304e-06 (rank : 702)	NC score	0.067099 (rank : 985)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1788	Shared Neighborhood Hits	484
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TIE1_MOUSE
θ value	1.69304e-06 (rank : 703)	NC score	0.659553 (rank : 711)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1266	Shared Neighborhood Hits	832
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

MILK1_HUMAN
θ value	2.21117e-06 (rank : 704)	NC score	0.048691 (rank : 1154)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	171
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

RERE_MOUSE
θ value	2.21117e-06 (rank : 705)	NC score	0.062937 (rank : 1015)
Query Neighborhood Hits	1804	Target Neighborhood Hits	785	Shared Neighborhood Hits	269
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RIPK5_HUMAN
θ value	2.21117e-06 (rank : 706)	NC score	0.832749 (rank : 468)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	831
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

AL2S2_HUMAN
θ value	2.88788e-06 (rank : 707)	NC score	0.765995 (rank : 576)
Query Neighborhood Hits	1804	Target Neighborhood Hits	727	Shared Neighborhood Hits	713
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

GSCR1_HUMAN
θ value	2.88788e-06 (rank : 708)	NC score	0.075074 (rank : 946)
Query Neighborhood Hits	1804	Target Neighborhood Hits	674	Shared Neighborhood Hits	257
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCK_HUMAN
θ value	2.88788e-06 (rank : 709)	NC score	0.689218 (rank : 651)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1035	Shared Neighborhood Hits	845
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

MET_HUMAN
θ value	2.88788e-06 (rank : 710)	NC score	0.667809 (rank : 693)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	793
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MOS_MOUSE
θ value	2.88788e-06 (rank : 711)	NC score	0.796772 (rank : 557)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PINK1_HUMAN
θ value	2.88788e-06 (rank : 712)	NC score	0.778543 (rank : 569)
Query Neighborhood Hits	1804	Target Neighborhood Hits	741	Shared Neighborhood Hits	725
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RIPK5_MOUSE
θ value	2.88788e-06 (rank : 713)	NC score	0.832099 (rank : 473)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

CDC7_MOUSE
θ value	3.77169e-06 (rank : 714)	NC score	0.747332 (rank : 588)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

EPHA3_MOUSE
θ value	3.77169e-06 (rank : 715)	NC score	0.657214 (rank : 714)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	827
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

MET_MOUSE
θ value	3.77169e-06 (rank : 716)	NC score	0.670978 (rank : 686)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	795
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

RET_HUMAN
θ value	3.77169e-06 (rank : 717)	NC score	0.684607 (rank : 660)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	807
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

UFO_HUMAN
θ value	3.77169e-06 (rank : 718)	NC score	0.645072 (rank : 744)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	779
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

BAT2_HUMAN
θ value	4.92598e-06 (rank : 719)	NC score	0.091477 (rank : 908)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	403
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

EPHA2_HUMAN
θ value	4.92598e-06 (rank : 720)	NC score	0.657673 (rank : 713)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1021	Shared Neighborhood Hits	828
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB3_MOUSE
θ value	4.92598e-06 (rank : 721)	NC score	0.640401 (rank : 749)
Query Neighborhood Hits	1804	Target Neighborhood Hits	996	Shared Neighborhood Hits	823
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

HCK_MOUSE
θ value	4.92598e-06 (rank : 722)	NC score	0.682588 (rank : 665)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1029	Shared Neighborhood Hits	842
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KSR1_HUMAN
θ value	4.92598e-06 (rank : 723)	NC score	0.734993 (rank : 595)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	804
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MERTK_HUMAN
θ value	4.92598e-06 (rank : 724)	NC score	0.627209 (rank : 764)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	777
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PCLO_HUMAN
θ value	4.92598e-06 (rank : 725)	NC score	0.116127 (rank : 865)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2046	Shared Neighborhood Hits	618
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

VGFR2_HUMAN
θ value	4.92598e-06 (rank : 726)	NC score	0.608885 (rank : 785)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	803
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	4.92598e-06 (rank : 727)	NC score	0.612676 (rank : 781)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1089	Shared Neighborhood Hits	801
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA2_MOUSE
θ value	6.43352e-06 (rank : 728)	NC score	0.656607 (rank : 716)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	822
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FYN_MOUSE
θ value	6.43352e-06 (rank : 729)	NC score	0.682345 (rank : 667)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1073	Shared Neighborhood Hits	853
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

KIT_MOUSE
θ value	6.43352e-06 (rank : 730)	NC score	0.604995 (rank : 791)
Query Neighborhood Hits	1804	Target Neighborhood Hits	949	Shared Neighborhood Hits	794
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MILK2_HUMAN
θ value	6.43352e-06 (rank : 731)	NC score	0.041099 (rank : 1214)
Query Neighborhood Hits	1804	Target Neighborhood Hits	457	Shared Neighborhood Hits	165
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

AAK1_HUMAN
θ value	8.40245e-06 (rank : 732)	NC score	0.831909 (rank : 474)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1077	Shared Neighborhood Hits	917
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AL2S2_MOUSE
θ value	8.40245e-06 (rank : 733)	NC score	0.751498 (rank : 585)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	691
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

GRASP_HUMAN
θ value	8.40245e-06 (rank : 734)	NC score	0.125439 (rank : 862)
Query Neighborhood Hits	1804	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_MOUSE
θ value	8.40245e-06 (rank : 735)	NC score	0.126005 (rank : 861)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

INSR_MOUSE
θ value	8.40245e-06 (rank : 736)	NC score	0.648027 (rank : 739)
Query Neighborhood Hits	1804	Target Neighborhood Hits	968	Shared Neighborhood Hits	799
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MOK_HUMAN
θ value	8.40245e-06 (rank : 737)	NC score	0.833072 (rank : 465)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	801
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

UFO_MOUSE
θ value	8.40245e-06 (rank : 738)	NC score	0.649331 (rank : 737)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	772
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

WEE1B_HUMAN
θ value	8.40245e-06 (rank : 739)	NC score	0.799426 (rank : 549)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	775
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1B_MOUSE
θ value	8.40245e-06 (rank : 740)	NC score	0.792735 (rank : 562)
Query Neighborhood Hits	1804	Target Neighborhood Hits	765	Shared Neighborhood Hits	738
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CDC7_HUMAN
θ value	1.09739e-05 (rank : 741)	NC score	0.745079 (rank : 589)
Query Neighborhood Hits	1804	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CSKI2_MOUSE
θ value	1.09739e-05 (rank : 742)	NC score	0.055878 (rank : 1077)
Query Neighborhood Hits	1804	Target Neighborhood Hits	812	Shared Neighborhood Hits	262
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA1_MOUSE
θ value	1.09739e-05 (rank : 743)	NC score	0.641233 (rank : 747)
Query Neighborhood Hits	1804	Target Neighborhood Hits	958	Shared Neighborhood Hits	803
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

FGFR3_MOUSE
θ value	1.09739e-05 (rank : 744)	NC score	0.663418 (rank : 703)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1059	Shared Neighborhood Hits	815
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

INSR_HUMAN
θ value	1.09739e-05 (rank : 745)	NC score	0.648966 (rank : 738)
Query Neighborhood Hits	1804	Target Neighborhood Hits	963	Shared Neighborhood Hits	803
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TARA_HUMAN
θ value	1.09739e-05 (rank : 746)	NC score	0.100731 (rank : 882)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1626	Shared Neighborhood Hits	483
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

VGFR1_MOUSE
θ value	1.09739e-05 (rank : 747)	NC score	0.616696 (rank : 779)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1118	Shared Neighborhood Hits	808
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

AFF1_MOUSE
θ value	1.43324e-05 (rank : 748)	NC score	0.060780 (rank : 1036)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	152
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

FGR_MOUSE
θ value	1.43324e-05 (rank : 749)	NC score	0.665549 (rank : 697)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1069	Shared Neighborhood Hits	848
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

KC1G1_HUMAN
θ value	1.43324e-05 (rank : 750)	NC score	0.700678 (rank : 637)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

PDZD3_MOUSE
θ value	1.43324e-05 (rank : 751)	NC score	0.104048 (rank : 876)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

ROR2_HUMAN
θ value	1.43324e-05 (rank : 752)	NC score	0.634990 (rank : 755)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1014	Shared Neighborhood Hits	792
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

AAK1_MOUSE
θ value	1.87187e-05 (rank : 753)	NC score	0.831121 (rank : 480)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1051	Shared Neighborhood Hits	909
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KC1G1_MOUSE
θ value	1.87187e-05 (rank : 754)	NC score	0.701902 (rank : 633)
Query Neighborhood Hits	1804	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KIT_HUMAN
θ value	1.87187e-05 (rank : 755)	NC score	0.608458 (rank : 787)
Query Neighborhood Hits	1804	Target Neighborhood Hits	953	Shared Neighborhood Hits	794
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ROS_HUMAN
θ value	1.87187e-05 (rank : 756)	NC score	0.651006 (rank : 734)
Query Neighborhood Hits	1804	Target Neighborhood Hits	907	Shared Neighborhood Hits	768
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

VGFR1_HUMAN
θ value	1.87187e-05 (rank : 757)	NC score	0.609101 (rank : 784)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1109	Shared Neighborhood Hits	804
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

BAT2_MOUSE
θ value	2.44474e-05 (rank : 758)	NC score	0.082127 (rank : 925)
Query Neighborhood Hits	1804	Target Neighborhood Hits	947	Shared Neighborhood Hits	397
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

FGFR4_MOUSE
θ value	2.44474e-05 (rank : 759)	NC score	0.628593 (rank : 762)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	795
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FGR_HUMAN
θ value	2.44474e-05 (rank : 760)	NC score	0.670215 (rank : 687)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1067	Shared Neighborhood Hits	851
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MLKL_MOUSE
θ value	2.44474e-05 (rank : 761)	NC score	0.654546 (rank : 722)
Query Neighborhood Hits	1804	Target Neighborhood Hits	707	Shared Neighborhood Hits	691
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

YES_HUMAN
θ value	2.44474e-05 (rank : 762)	NC score	0.674791 (rank : 678)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1059	Shared Neighborhood Hits	847
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	2.44474e-05 (rank : 763)	NC score	0.674336 (rank : 681)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1052	Shared Neighborhood Hits	840
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

IRAK3_MOUSE
θ value	3.19293e-05 (rank : 764)	NC score	0.621212 (rank : 771)
Query Neighborhood Hits	1804	Target Neighborhood Hits	628	Shared Neighborhood Hits	608
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KC1D_HUMAN
θ value	3.19293e-05 (rank : 765)	NC score	0.687630 (rank : 652)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	728
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	3.19293e-05 (rank : 766)	NC score	0.687605 (rank : 653)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	728
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	3.19293e-05 (rank : 767)	NC score	0.685909 (rank : 657)
Query Neighborhood Hits	1804	Target Neighborhood Hits	732	Shared Neighborhood Hits	725
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	3.19293e-05 (rank : 768)	NC score	0.685891 (rank : 658)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

PHC1_MOUSE
θ value	3.19293e-05 (rank : 769)	NC score	0.032917 (rank : 1276)
Query Neighborhood Hits	1804	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

STK16_MOUSE
θ value	3.19293e-05 (rank : 770)	NC score	0.857856 (rank : 376)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	814
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

ACK1_MOUSE
θ value	4.1701e-05 (rank : 771)	NC score	0.683466 (rank : 663)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1080	Shared Neighborhood Hits	916
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ALK_HUMAN
θ value	4.1701e-05 (rank : 772)	NC score	0.619464 (rank : 773)
Query Neighborhood Hits	1804	Target Neighborhood Hits	795	Shared Neighborhood Hits	741
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ARHGB_HUMAN
θ value	4.1701e-05 (rank : 773)	NC score	0.066713 (rank : 988)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	168
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

IRAK3_HUMAN
θ value	4.1701e-05 (rank : 774)	NC score	0.633045 (rank : 760)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	629
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MAGI2_HUMAN
θ value	4.1701e-05 (rank : 775)	NC score	0.085679 (rank : 917)
Query Neighborhood Hits	1804	Target Neighborhood Hits	373	Shared Neighborhood Hits	191
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

RON_MOUSE
θ value	4.1701e-05 (rank : 776)	NC score	0.659803 (rank : 709)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	794
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TIE1_HUMAN
θ value	4.1701e-05 (rank : 777)	NC score	0.656902 (rank : 715)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1241	Shared Neighborhood Hits	829
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TTBK1_HUMAN
θ value	4.1701e-05 (rank : 778)	NC score	0.712684 (rank : 618)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	822
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

WEE1_MOUSE
θ value	4.1701e-05 (rank : 779)	NC score	0.816389 (rank : 522)
Query Neighborhood Hits	1804	Target Neighborhood Hits	794	Shared Neighborhood Hits	766
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

ACK1_HUMAN
θ value	5.44631e-05 (rank : 780)	NC score	0.685614 (rank : 659)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1140	Shared Neighborhood Hits	944
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

AFF4_HUMAN
θ value	5.44631e-05 (rank : 781)	NC score	0.057162 (rank : 1067)
Query Neighborhood Hits	1804	Target Neighborhood Hits	611	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

FLT3_HUMAN
θ value	5.44631e-05 (rank : 782)	NC score	0.604727 (rank : 792)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	787
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

INSRR_MOUSE
θ value	5.44631e-05 (rank : 783)	NC score	0.627144 (rank : 765)
Query Neighborhood Hits	1804	Target Neighborhood Hits	961	Shared Neighborhood Hits	782
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KC1G3_HUMAN
θ value	5.44631e-05 (rank : 784)	NC score	0.695579 (rank : 642)
Query Neighborhood Hits	1804	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

ALK_MOUSE
θ value	7.1131e-05 (rank : 785)	NC score	0.616964 (rank : 777)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	756
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

INSRR_HUMAN
θ value	7.1131e-05 (rank : 786)	NC score	0.624716 (rank : 768)
Query Neighborhood Hits	1804	Target Neighborhood Hits	950	Shared Neighborhood Hits	785
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KC1G2_MOUSE
θ value	7.1131e-05 (rank : 787)	NC score	0.673721 (rank : 682)
Query Neighborhood Hits	1804	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MILK1_MOUSE
θ value	7.1131e-05 (rank : 788)	NC score	0.058505 (rank : 1055)
Query Neighborhood Hits	1804	Target Neighborhood Hits	788	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NOLC1_HUMAN
θ value	7.1131e-05 (rank : 789)	NC score	0.070556 (rank : 960)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	187
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PDZD3_HUMAN
θ value	7.1131e-05 (rank : 790)	NC score	0.101824 (rank : 881)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	123
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

KC1G2_HUMAN
θ value	9.29e-05 (rank : 791)	NC score	0.670011 (rank : 688)
Query Neighborhood Hits	1804	Target Neighborhood Hits	693	Shared Neighborhood Hits	691
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MLL3_HUMAN
θ value	9.29e-05 (rank : 792)	NC score	0.073656 (rank : 950)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1644	Shared Neighborhood Hits	492
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ROR2_MOUSE
θ value	9.29e-05 (rank : 793)	NC score	0.605938 (rank : 790)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1000	Shared Neighborhood Hits	770
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

CSF1R_HUMAN
θ value	0.000121331 (rank : 794)	NC score	0.576817 (rank : 799)
Query Neighborhood Hits	1804	Target Neighborhood Hits	943	Shared Neighborhood Hits	789
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	0.000121331 (rank : 795)	NC score	0.572623 (rank : 800)
Query Neighborhood Hits	1804	Target Neighborhood Hits	983	Shared Neighborhood Hits	787
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FLT3_MOUSE
θ value	0.000121331 (rank : 796)	NC score	0.601806 (rank : 796)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	788
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

MAGI2_MOUSE
θ value	0.000121331 (rank : 797)	NC score	0.083590 (rank : 919)
Query Neighborhood Hits	1804	Target Neighborhood Hits	370	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

STK16_HUMAN
θ value	0.000121331 (rank : 798)	NC score	0.861483 (rank : 369)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	818
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

SYNJ1_HUMAN
θ value	0.000121331 (rank : 799)	NC score	0.050176 (rank : 1135)
Query Neighborhood Hits	1804	Target Neighborhood Hits	498	Shared Neighborhood Hits	210
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCOF_HUMAN
θ value	0.000121331 (rank : 800)	NC score	0.072264 (rank : 954)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	211
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

IGF1R_MOUSE
θ value	0.000158464 (rank : 801)	NC score	0.624887 (rank : 767)
Query Neighborhood Hits	1804	Target Neighborhood Hits	973	Shared Neighborhood Hits	792
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IRAK1_MOUSE
θ value	0.000158464 (rank : 802)	NC score	0.730312 (rank : 600)
Query Neighborhood Hits	1804	Target Neighborhood Hits	784	Shared Neighborhood Hits	752
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

KC1A_HUMAN
θ value	0.000158464 (rank : 803)	NC score	0.695543 (rank : 643)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.000158464 (rank : 804)	NC score	0.695543 (rank : 644)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

LTK_HUMAN
θ value	0.000158464 (rank : 805)	NC score	0.603697 (rank : 795)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	749
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MAGI1_MOUSE
θ value	0.000158464 (rank : 806)	NC score	0.087164 (rank : 911)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	187
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

IRAK2_HUMAN
θ value	0.00020696 (rank : 807)	NC score	0.665984 (rank : 696)
Query Neighborhood Hits	1804	Target Neighborhood Hits	714	Shared Neighborhood Hits	688
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

MINT_MOUSE
θ value	0.00020696 (rank : 808)	NC score	0.069682 (rank : 964)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1514	Shared Neighborhood Hits	457
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PGFRA_HUMAN
θ value	0.00020696 (rank : 809)	NC score	0.618404 (rank : 774)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	792
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	0.00020696 (rank : 810)	NC score	0.616811 (rank : 778)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	791
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TTBK2_HUMAN
θ value	0.00020696 (rank : 811)	NC score	0.697636 (rank : 639)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	741
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	0.00020696 (rank : 812)	NC score	0.694821 (rank : 646)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	738
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

CSKI1_HUMAN
θ value	0.000270298 (rank : 813)	NC score	0.065860 (rank : 994)
Query Neighborhood Hits	1804	Target Neighborhood Hits	997	Shared Neighborhood Hits	340
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

IRAK1_HUMAN
θ value	0.000270298 (rank : 814)	NC score	0.731714 (rank : 598)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	770
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

MAGI1_HUMAN
θ value	0.000270298 (rank : 815)	NC score	0.089309 (rank : 909)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	181
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

SC24C_HUMAN
θ value	0.000270298 (rank : 816)	NC score	0.059988 (rank : 1043)
Query Neighborhood Hits	1804	Target Neighborhood Hits	662	Shared Neighborhood Hits	273
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TOIP2_MOUSE
θ value	0.000270298 (rank : 817)	NC score	0.022719 (rank : 1419)
Query Neighborhood Hits	1804	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

ACVR1_MOUSE
θ value	0.00035302 (rank : 818)	NC score	0.661232 (rank : 706)
Query Neighborhood Hits	1804	Target Neighborhood Hits	768	Shared Neighborhood Hits	756
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

IGF1R_HUMAN
θ value	0.00035302 (rank : 819)	NC score	0.621950 (rank : 770)
Query Neighborhood Hits	1804	Target Neighborhood Hits	977	Shared Neighborhood Hits	794
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

K1802_MOUSE
θ value	0.00035302 (rank : 820)	NC score	0.061547 (rank : 1025)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1596	Shared Neighborhood Hits	435
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

RERE_HUMAN
θ value	0.00035302 (rank : 821)	NC score	0.060320 (rank : 1041)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	269
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RON_HUMAN
θ value	0.00035302 (rank : 822)	NC score	0.669103 (rank : 689)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

SRMS_HUMAN
θ value	0.00035302 (rank : 823)	NC score	0.695035 (rank : 645)
Query Neighborhood Hits	1804	Target Neighborhood Hits	946	Shared Neighborhood Hits	828
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TCOF_MOUSE
θ value	0.00035302 (rank : 824)	NC score	0.077109 (rank : 941)
Query Neighborhood Hits	1804	Target Neighborhood Hits	471	Shared Neighborhood Hits	188
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TEX14_MOUSE
θ value	0.00035302 (rank : 825)	NC score	0.492782 (rank : 820)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1333	Shared Neighborhood Hits	721
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

UHMK1_HUMAN
θ value	0.00035302 (rank : 826)	NC score	0.802608 (rank : 544)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	766
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
θ value	0.00035302 (rank : 827)	NC score	0.800808 (rank : 546)
Query Neighborhood Hits	1804	Target Neighborhood Hits	809	Shared Neighborhood Hits	766
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ACVR1_HUMAN
θ value	0.000461057 (rank : 828)	NC score	0.655784 (rank : 719)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	750
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ERBB3_HUMAN
θ value	0.000461057 (rank : 829)	NC score	0.637345 (rank : 753)
Query Neighborhood Hits	1804	Target Neighborhood Hits	918	Shared Neighborhood Hits	778
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

KC1AL_HUMAN
θ value	0.000461057 (rank : 830)	NC score	0.697717 (rank : 638)
Query Neighborhood Hits	1804	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

SRMS_MOUSE
θ value	0.000461057 (rank : 831)	NC score	0.701277 (rank : 635)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	829
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

AFF4_MOUSE
θ value	0.000602161 (rank : 832)	NC score	0.058215 (rank : 1059)
Query Neighborhood Hits	1804	Target Neighborhood Hits	581	Shared Neighborhood Hits	210
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ANPRB_HUMAN
θ value	0.000602161 (rank : 833)	NC score	0.472623 (rank : 823)
Query Neighborhood Hits	1804	Target Neighborhood Hits	646	Shared Neighborhood Hits	583
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ATN1_HUMAN
θ value	0.000602161 (rank : 834)	NC score	0.077235 (rank : 940)
Query Neighborhood Hits	1804	Target Neighborhood Hits	676	Shared Neighborhood Hits	245
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

WHRN_MOUSE
θ value	0.000602161 (rank : 835)	NC score	0.083343 (rank : 921)
Query Neighborhood Hits	1804	Target Neighborhood Hits	412	Shared Neighborhood Hits	217
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

NCOR2_MOUSE
θ value	0.000786445 (rank : 836)	NC score	0.064798 (rank : 1001)
Query Neighborhood Hits	1804	Target Neighborhood Hits	790	Shared Neighborhood Hits	246
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

SFR16_MOUSE
θ value	0.000786445 (rank : 837)	NC score	0.042724 (rank : 1200)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

SHAN1_HUMAN
θ value	0.000786445 (rank : 838)	NC score	0.083704 (rank : 918)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1041	Shared Neighborhood Hits	366
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

BMR1B_MOUSE
θ value	0.00102713 (rank : 839)	NC score	0.642407 (rank : 746)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	744
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

NHERF_MOUSE
θ value	0.00102713 (rank : 840)	NC score	0.096861 (rank : 897)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	127
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

SFPQ_HUMAN
θ value	0.00102713 (rank : 841)	NC score	0.053197 (rank : 1095)
Query Neighborhood Hits	1804	Target Neighborhood Hits	986	Shared Neighborhood Hits	265
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

WEE1_HUMAN
θ value	0.00102713 (rank : 842)	NC score	0.805882 (rank : 540)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	746
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

WIRE_HUMAN
θ value	0.00102713 (rank : 843)	NC score	0.065183 (rank : 998)
Query Neighborhood Hits	1804	Target Neighborhood Hits	329	Shared Neighborhood Hits	153
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

BMR1B_HUMAN
θ value	0.00134147 (rank : 844)	NC score	0.641009 (rank : 748)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	743
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

ENAH_MOUSE
θ value	0.00134147 (rank : 845)	NC score	0.063855 (rank : 1007)
Query Neighborhood Hits	1804	Target Neighborhood Hits	919	Shared Neighborhood Hits	256
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GRIN1_HUMAN
θ value	0.00134147 (rank : 846)	NC score	0.092210 (rank : 906)
Query Neighborhood Hits	1804	Target Neighborhood Hits	681	Shared Neighborhood Hits	294
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

MARCS_HUMAN
θ value	0.00134147 (rank : 847)	NC score	0.067323 (rank : 981)
Query Neighborhood Hits	1804	Target Neighborhood Hits	204	Shared Neighborhood Hits	101
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

MPDZ_HUMAN
θ value	0.00134147 (rank : 848)	NC score	0.067930 (rank : 979)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	134
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MPDZ_MOUSE
θ value	0.00134147 (rank : 849)	NC score	0.069079 (rank : 968)
Query Neighborhood Hits	1804	Target Neighborhood Hits	298	Shared Neighborhood Hits	153
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

PDLI1_MOUSE
θ value	0.00134147 (rank : 850)	NC score	0.051563 (rank : 1112)
Query Neighborhood Hits	1804	Target Neighborhood Hits	213	Shared Neighborhood Hits	90
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PRB4S_HUMAN
θ value	0.00134147 (rank : 851)	NC score	0.082719 (rank : 923)
Query Neighborhood Hits	1804	Target Neighborhood Hits	330	Shared Neighborhood Hits	157
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRP1_HUMAN
θ value	0.00134147 (rank : 852)	NC score	0.078198 (rank : 936)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	179
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

ROBO3_HUMAN
θ value	0.00134147 (rank : 853)	NC score	0.047454 (rank : 1161)
Query Neighborhood Hits	1804	Target Neighborhood Hits	570	Shared Neighborhood Hits	138
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

TAU_HUMAN
θ value	0.00134147 (rank : 854)	NC score	0.062040 (rank : 1021)
Query Neighborhood Hits	1804	Target Neighborhood Hits	448	Shared Neighborhood Hits	217
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ACVL1_MOUSE
θ value	0.00175202 (rank : 855)	NC score	0.615135 (rank : 780)
Query Neighborhood Hits	1804	Target Neighborhood Hits	739	Shared Neighborhood Hits	732
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

BSN_MOUSE
θ value	0.00175202 (rank : 856)	NC score	0.114549 (rank : 867)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2057	Shared Neighborhood Hits	642
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CT151_HUMAN
θ value	0.00175202 (rank : 857)	NC score	0.061137 (rank : 1032)
Query Neighborhood Hits	1804	Target Neighborhood Hits	382	Shared Neighborhood Hits	134
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

YLPM1_HUMAN
θ value	0.00175202 (rank : 858)	NC score	0.068095 (rank : 976)
Query Neighborhood Hits	1804	Target Neighborhood Hits	670	Shared Neighborhood Hits	258
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

HCN4_MOUSE
θ value	0.00228821 (rank : 859)	NC score	0.029246 (rank : 1317)
Query Neighborhood Hits	1804	Target Neighborhood Hits	284	Shared Neighborhood Hits	118
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

NHERF_HUMAN
θ value	0.00228821 (rank : 860)	NC score	0.093108 (rank : 903)
Query Neighborhood Hits	1804	Target Neighborhood Hits	190	Shared Neighborhood Hits	127
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHRF2_HUMAN
θ value	0.00228821 (rank : 861)	NC score	0.100427 (rank : 884)
Query Neighborhood Hits	1804	Target Neighborhood Hits	197	Shared Neighborhood Hits	125
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

RYK_MOUSE
θ value	0.00228821 (rank : 862)	NC score	0.562038 (rank : 802)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	699
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ANPRB_MOUSE
θ value	0.00298849 (rank : 863)	NC score	0.439651 (rank : 831)
Query Neighborhood Hits	1804	Target Neighborhood Hits	607	Shared Neighborhood Hits	558
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ARHGC_HUMAN
θ value	0.00298849 (rank : 864)	NC score	0.054167 (rank : 1087)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BMR1A_HUMAN
θ value	0.00298849 (rank : 865)	NC score	0.651897 (rank : 731)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	746
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

MUC1_MOUSE
θ value	0.00298849 (rank : 866)	NC score	0.065152 (rank : 999)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	145
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

NCOA6_MOUSE
θ value	0.00298849 (rank : 867)	NC score	0.086340 (rank : 913)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1076	Shared Neighborhood Hits	412
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

OGFR_HUMAN
θ value	0.00298849 (rank : 868)	NC score	0.104046 (rank : 877)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1582	Shared Neighborhood Hits	576
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ZAN_HUMAN
θ value	0.00298849 (rank : 869)	NC score	0.016098 (rank : 1519)
Query Neighborhood Hits	1804	Target Neighborhood Hits	679	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

AVR2A_HUMAN
θ value	0.00390308 (rank : 870)	NC score	0.673423 (rank : 684)
Query Neighborhood Hits	1804	Target Neighborhood Hits	767	Shared Neighborhood Hits	759
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	0.00390308 (rank : 871)	NC score	0.673437 (rank : 683)
Query Neighborhood Hits	1804	Target Neighborhood Hits	767	Shared Neighborhood Hits	759
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BMR1A_MOUSE
θ value	0.00390308 (rank : 872)	NC score	0.650697 (rank : 735)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	745
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BRD4_HUMAN
θ value	0.00390308 (rank : 873)	NC score	0.045914 (rank : 1174)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	260
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

LDB3_HUMAN
θ value	0.00390308 (rank : 874)	NC score	0.037788 (rank : 1238)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	195
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

NHRF2_MOUSE
θ value	0.00390308 (rank : 875)	NC score	0.099987 (rank : 885)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	128
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

REV1_MOUSE
θ value	0.00390308 (rank : 876)	NC score	0.017403 (rank : 1496)
Query Neighborhood Hits	1804	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

STYK1_HUMAN
θ value	0.00390308 (rank : 877)	NC score	0.668653 (rank : 691)
Query Neighborhood Hits	1804	Target Neighborhood Hits	786	Shared Neighborhood Hits	770
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	0.00390308 (rank : 878)	NC score	0.652123 (rank : 730)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	767
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TARA_MOUSE
θ value	0.00390308 (rank : 879)	NC score	0.068492 (rank : 971)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1133	Shared Neighborhood Hits	322
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

AATK_MOUSE
θ value	0.00509761 (rank : 880)	NC score	0.652886 (rank : 727)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	836
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

CNOT3_MOUSE
θ value	0.00509761 (rank : 881)	NC score	0.061277 (rank : 1030)
Query Neighborhood Hits	1804	Target Neighborhood Hits	504	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

EPHB6_HUMAN
θ value	0.00509761 (rank : 882)	NC score	0.533051 (rank : 815)
Query Neighborhood Hits	1804	Target Neighborhood Hits	912	Shared Neighborhood Hits	706
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

INADL_HUMAN
θ value	0.00509761 (rank : 883)	NC score	0.063603 (rank : 1009)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	134
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

K1802_HUMAN
θ value	0.00509761 (rank : 884)	NC score	0.039149 (rank : 1227)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1378	Shared Neighborhood Hits	359
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SCYL2_HUMAN
θ value	0.00509761 (rank : 885)	NC score	0.655105 (rank : 721)
Query Neighborhood Hits	1804	Target Neighborhood Hits	632	Shared Neighborhood Hits	571
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ANK2_HUMAN
θ value	0.00665767 (rank : 886)	NC score	0.065952 (rank : 993)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1615	Shared Neighborhood Hits	498
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARHGC_MOUSE
θ value	0.00665767 (rank : 887)	NC score	0.053060 (rank : 1098)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	141
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BASP_MOUSE
θ value	0.00665767 (rank : 888)	NC score	0.079050 (rank : 933)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	128
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CO4A4_HUMAN
θ value	0.00665767 (rank : 889)	NC score	0.021752 (rank : 1430)
Query Neighborhood Hits	1804	Target Neighborhood Hits	440	Shared Neighborhood Hits	136
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

EPHB6_MOUSE
θ value	0.00665767 (rank : 890)	NC score	0.547737 (rank : 806)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	732
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB3_MOUSE
θ value	0.00665767 (rank : 891)	NC score	0.638470 (rank : 752)
Query Neighborhood Hits	1804	Target Neighborhood Hits	898	Shared Neighborhood Hits	782
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

NSD1_HUMAN
θ value	0.00665767 (rank : 892)	NC score	0.027164 (rank : 1349)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	148
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

RHPN1_HUMAN
θ value	0.00665767 (rank : 893)	NC score	0.067098 (rank : 986)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	0.00665767 (rank : 894)	NC score	0.081707 (rank : 928)
Query Neighborhood Hits	1804	Target Neighborhood Hits	154	Shared Neighborhood Hits	113
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RYK_HUMAN
θ value	0.00665767 (rank : 895)	NC score	0.545834 (rank : 808)
Query Neighborhood Hits	1804	Target Neighborhood Hits	701	Shared Neighborhood Hits	687
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

SHAN2_HUMAN
θ value	0.00665767 (rank : 896)	NC score	0.099753 (rank : 887)
Query Neighborhood Hits	1804	Target Neighborhood Hits	346	Shared Neighborhood Hits	209
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SHAN2_MOUSE
θ value	0.00665767 (rank : 897)	NC score	0.098770 (rank : 889)
Query Neighborhood Hits	1804	Target Neighborhood Hits	446	Shared Neighborhood Hits	216
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SYT4_HUMAN
θ value	0.00665767 (rank : 898)	NC score	0.020547 (rank : 1449)
Query Neighborhood Hits	1804	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

ACVL1_HUMAN
θ value	0.00869519 (rank : 899)	NC score	0.592285 (rank : 797)
Query Neighborhood Hits	1804	Target Neighborhood Hits	716	Shared Neighborhood Hits	709
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

BRD4_MOUSE
θ value	0.00869519 (rank : 900)	NC score	0.046133 (rank : 1171)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	256
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CBP_MOUSE
θ value	0.00869519 (rank : 901)	NC score	0.066071 (rank : 992)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1051	Shared Neighborhood Hits	392
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

IWS1_MOUSE
θ value	0.00869519 (rank : 902)	NC score	0.063822 (rank : 1008)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1258	Shared Neighborhood Hits	364
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MDC1_MOUSE
θ value	0.00869519 (rank : 903)	NC score	0.108177 (rank : 874)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	427
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUC13_MOUSE
θ value	0.00869519 (rank : 904)	NC score	0.048501 (rank : 1156)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	136
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

NCOR1_HUMAN
θ value	0.00869519 (rank : 905)	NC score	0.046661 (rank : 1168)
Query Neighborhood Hits	1804	Target Neighborhood Hits	577	Shared Neighborhood Hits	171
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

PI5PA_MOUSE
θ value	0.00869519 (rank : 906)	NC score	0.044197 (rank : 1192)
Query Neighborhood Hits	1804	Target Neighborhood Hits	331	Shared Neighborhood Hits	157
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PRAX_MOUSE
θ value	0.00869519 (rank : 907)	NC score	0.047003 (rank : 1166)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	103
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

SYN1_MOUSE
θ value	0.00869519 (rank : 908)	NC score	0.045201 (rank : 1182)
Query Neighborhood Hits	1804	Target Neighborhood Hits	363	Shared Neighborhood Hits	171
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

AATK_HUMAN
θ value	0.0113563 (rank : 909)	NC score	0.664988 (rank : 699)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1243	Shared Neighborhood Hits	963
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

BRDT_MOUSE
θ value	0.0113563 (rank : 910)	NC score	0.019839 (rank : 1458)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	68
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

CEND3_HUMAN
θ value	0.0113563 (rank : 911)	NC score	0.017616 (rank : 1491)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CNOT3_HUMAN
θ value	0.0113563 (rank : 912)	NC score	0.053726 (rank : 1092)
Query Neighborhood Hits	1804	Target Neighborhood Hits	425	Shared Neighborhood Hits	133
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CO3A1_HUMAN
θ value	0.0113563 (rank : 913)	NC score	0.025196 (rank : 1382)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	148
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CSPG3_MOUSE
θ value	0.0113563 (rank : 914)	NC score	-0.001497 (rank : 1782)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	107
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

GA2L1_MOUSE
θ value	0.0113563 (rank : 915)	NC score	0.027981 (rank : 1336)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

GTSE1_HUMAN
θ value	0.0113563 (rank : 916)	NC score	0.059639 (rank : 1046)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

HMGA2_HUMAN
θ value	0.0113563 (rank : 917)	NC score	0.040375 (rank : 1220)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	23
SwissProt Accessions	P52926	Gene names	HMGA2, HMGIC
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

PHLB1_MOUSE
θ value	0.0113563 (rank : 918)	NC score	0.039164 (rank : 1225)
Query Neighborhood Hits	1804	Target Neighborhood Hits	678	Shared Neighborhood Hits	176
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RPGF6_HUMAN
θ value	0.0113563 (rank : 919)	NC score	0.045275 (rank : 1180)
Query Neighborhood Hits	1804	Target Neighborhood Hits	266	Shared Neighborhood Hits	131
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TGFR1_HUMAN
θ value	0.0113563 (rank : 920)	NC score	0.634791 (rank : 756)
Query Neighborhood Hits	1804	Target Neighborhood Hits	755	Shared Neighborhood Hits	746
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	0.0113563 (rank : 921)	NC score	0.634392 (rank : 757)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	746
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

WHRN_HUMAN
θ value	0.0113563 (rank : 922)	NC score	0.074782 (rank : 947)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	179
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

ACV1B_HUMAN
θ value	0.0148317 (rank : 923)	NC score	0.638791 (rank : 751)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	747
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	0.0148317 (rank : 924)	NC score	0.638837 (rank : 750)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	746
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

BAG3_MOUSE
θ value	0.0148317 (rank : 925)	NC score	0.063089 (rank : 1014)
Query Neighborhood Hits	1804	Target Neighborhood Hits	513	Shared Neighborhood Hits	247
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BSN_HUMAN
θ value	0.0148317 (rank : 926)	NC score	0.098142 (rank : 890)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1537	Shared Neighborhood Hits	499
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CIZ1_HUMAN
θ value	0.0148317 (rank : 927)	NC score	0.043227 (rank : 1197)
Query Neighborhood Hits	1804	Target Neighborhood Hits	359	Shared Neighborhood Hits	134
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

EP300_HUMAN
θ value	0.0148317 (rank : 928)	NC score	0.055434 (rank : 1080)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	301
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

EP400_MOUSE
θ value	0.0148317 (rank : 929)	NC score	0.024682 (rank : 1390)
Query Neighborhood Hits	1804	Target Neighborhood Hits	592	Shared Neighborhood Hits	191
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

GFC1_HUMAN
θ value	0.0148317 (rank : 930)	NC score	0.019072 (rank : 1469)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	37
SwissProt Accessions	P63117	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)1_Xq21.33 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein].

GLIS3_MOUSE
θ value	0.0148317 (rank : 931)	NC score	-0.019145 (rank : 1872)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	121
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

LRIG1_MOUSE
θ value	0.0148317 (rank : 932)	NC score	0.020934 (rank : 1441)
Query Neighborhood Hits	1804	Target Neighborhood Hits	627	Shared Neighborhood Hits	68
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

NCA11_MOUSE
θ value	0.0148317 (rank : 933)	NC score	0.051270 (rank : 1118)
Query Neighborhood Hits	1804	Target Neighborhood Hits	661	Shared Neighborhood Hits	185
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

PSD4_HUMAN
θ value	0.0148317 (rank : 934)	NC score	0.018747 (rank : 1477)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SREC2_MOUSE
θ value	0.0148317 (rank : 935)	NC score	0.006856 (rank : 1646)
Query Neighborhood Hits	1804	Target Neighborhood Hits	605	Shared Neighborhood Hits	119
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

TF3C2_HUMAN
θ value	0.0148317 (rank : 936)	NC score	0.020839 (rank : 1445)
Query Neighborhood Hits	1804	Target Neighborhood Hits	168	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

UBP10_HUMAN
θ value	0.0148317 (rank : 937)	NC score	0.011295 (rank : 1589)
Query Neighborhood Hits	1804	Target Neighborhood Hits	153	Shared Neighborhood Hits	47
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

ZO3_MOUSE
θ value	0.0148317 (rank : 938)	NC score	0.055528 (rank : 1078)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	130
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

APBA3_HUMAN
θ value	0.0193708 (rank : 939)	NC score	0.060683 (rank : 1038)
Query Neighborhood Hits	1804	Target Neighborhood Hits	201	Shared Neighborhood Hits	116
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

BAG3_HUMAN
θ value	0.0193708 (rank : 940)	NC score	0.049835 (rank : 1138)
Query Neighborhood Hits	1804	Target Neighborhood Hits	314	Shared Neighborhood Hits	164
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BASP_HUMAN
θ value	0.0193708 (rank : 941)	NC score	0.069378 (rank : 966)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	132
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CABIN_HUMAN
θ value	0.0193708 (rank : 942)	NC score	0.058663 (rank : 1054)
Query Neighborhood Hits	1804	Target Neighborhood Hits	490	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CBX4_HUMAN
θ value	0.0193708 (rank : 943)	NC score	0.010329 (rank : 1601)
Query Neighborhood Hits	1804	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

CS007_HUMAN
θ value	0.0193708 (rank : 944)	NC score	0.036371 (rank : 1247)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CU030_HUMAN
θ value	0.0193708 (rank : 945)	NC score	0.026323 (rank : 1367)
Query Neighborhood Hits	1804	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UFM2	Gene names	C21orf30
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C21orf30.

CXXC6_HUMAN
θ value	0.0193708 (rank : 946)	NC score	0.023763 (rank : 1400)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFU7, Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7	Gene names	CXXC6, KIAA1676, LCX
Domain Architecture	No domain graphic available
Description	CXXC-type zinc finger protein 6 (Leukemia-associated protein with a CXXC domain).

LAP4_HUMAN
θ value	0.0193708 (rank : 947)	NC score	0.041135 (rank : 1213)
Query Neighborhood Hits	1804	Target Neighborhood Hits	608	Shared Neighborhood Hits	186
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PDLI1_HUMAN
θ value	0.0193708 (rank : 948)	NC score	0.048066 (rank : 1160)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

RREB1_HUMAN
θ value	0.0193708 (rank : 949)	NC score	-0.016400 (rank : 1867)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	122
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

TEX14_HUMAN
θ value	0.0193708 (rank : 950)	NC score	0.451806 (rank : 828)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	665
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

VRK2_MOUSE
θ value	0.0193708 (rank : 951)	NC score	0.512646 (rank : 818)
Query Neighborhood Hits	1804	Target Neighborhood Hits	586	Shared Neighborhood Hits	576
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

WASIP_HUMAN
θ value	0.0193708 (rank : 952)	NC score	0.078066 (rank : 937)
Query Neighborhood Hits	1804	Target Neighborhood Hits	458	Shared Neighborhood Hits	202
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WASIP_MOUSE
θ value	0.0193708 (rank : 953)	NC score	0.069666 (rank : 965)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	184
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ZN447_HUMAN
θ value	0.0193708 (rank : 954)	NC score	-0.015780 (rank : 1865)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	112
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

ATX2_HUMAN
θ value	0.0252991 (rank : 955)	NC score	0.037613 (rank : 1239)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	145
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

AVR2B_HUMAN
θ value	0.0252991 (rank : 956)	NC score	0.659750 (rank : 710)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	738
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	0.0252991 (rank : 957)	NC score	0.659940 (rank : 708)
Query Neighborhood Hits	1804	Target Neighborhood Hits	749	Shared Neighborhood Hits	738
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CARD6_HUMAN
θ value	0.0252991 (rank : 958)	NC score	0.024755 (rank : 1388)
Query Neighborhood Hits	1804	Target Neighborhood Hits	145	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

CIC_MOUSE
θ value	0.0252991 (rank : 959)	NC score	0.041454 (rank : 1211)
Query Neighborhood Hits	1804	Target Neighborhood Hits	742	Shared Neighborhood Hits	276
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CJ012_HUMAN
θ value	0.0252991 (rank : 960)	NC score	0.067125 (rank : 984)
Query Neighborhood Hits	1804	Target Neighborhood Hits	467	Shared Neighborhood Hits	194
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

MARCS_MOUSE
θ value	0.0252991 (rank : 961)	NC score	0.062870 (rank : 1016)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	102
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

MAVS_HUMAN
θ value	0.0252991 (rank : 962)	NC score	0.052349 (rank : 1104)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	128
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MDC1_HUMAN
θ value	0.0252991 (rank : 963)	NC score	0.111100 (rank : 871)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1446	Shared Neighborhood Hits	501
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MLKL_HUMAN
θ value	0.0252991 (rank : 964)	NC score	0.548374 (rank : 805)
Query Neighborhood Hits	1804	Target Neighborhood Hits	600	Shared Neighborhood Hits	576
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

SCYL2_MOUSE
θ value	0.0252991 (rank : 965)	NC score	0.635269 (rank : 754)
Query Neighborhood Hits	1804	Target Neighborhood Hits	603	Shared Neighborhood Hits	550
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SOX13_HUMAN
θ value	0.0252991 (rank : 966)	NC score	0.025688 (rank : 1373)
Query Neighborhood Hits	1804	Target Neighborhood Hits	464	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

TACC3_HUMAN
θ value	0.0252991 (rank : 967)	NC score	0.048274 (rank : 1158)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TF3C2_MOUSE
θ value	0.0252991 (rank : 968)	NC score	0.018806 (rank : 1474)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

TTC28_HUMAN
θ value	0.0252991 (rank : 969)	NC score	0.020726 (rank : 1447)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	94
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

VRK2_HUMAN
θ value	0.0252991 (rank : 970)	NC score	0.494995 (rank : 819)
Query Neighborhood Hits	1804	Target Neighborhood Hits	582	Shared Neighborhood Hits	563
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

AMHR2_HUMAN
θ value	0.0330416 (rank : 971)	NC score	0.535705 (rank : 811)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	665
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ARI1A_HUMAN
θ value	0.0330416 (rank : 972)	NC score	0.053034 (rank : 1099)
Query Neighborhood Hits	1804	Target Neighborhood Hits	787	Shared Neighborhood Hits	302
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CRSP2_HUMAN
θ value	0.0330416 (rank : 973)	NC score	0.049511 (rank : 1145)
Query Neighborhood Hits	1804	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

ELOA2_HUMAN
θ value	0.0330416 (rank : 974)	NC score	0.026084 (rank : 1371)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

GUC2F_HUMAN
θ value	0.0330416 (rank : 975)	NC score	0.513475 (rank : 817)
Query Neighborhood Hits	1804	Target Neighborhood Hits	740	Shared Neighborhood Hits	676
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

K2002_HUMAN
θ value	0.0330416 (rank : 976)	NC score	0.367696 (rank : 840)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	264
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

LPP_HUMAN
θ value	0.0330416 (rank : 977)	NC score	0.052980 (rank : 1100)
Query Neighborhood Hits	1804	Target Neighborhood Hits	775	Shared Neighborhood Hits	305
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

PCQAP_HUMAN
θ value	0.0330416 (rank : 978)	NC score	0.062229 (rank : 1020)
Query Neighborhood Hits	1804	Target Neighborhood Hits	549	Shared Neighborhood Hits	180
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PININ_MOUSE
θ value	0.0330416 (rank : 979)	NC score	0.051686 (rank : 1110)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	155
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PPRB_HUMAN
θ value	0.0330416 (rank : 980)	NC score	0.049515 (rank : 1144)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	142
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

R51A1_MOUSE
θ value	0.0330416 (rank : 981)	NC score	0.033960 (rank : 1270)
Query Neighborhood Hits	1804	Target Neighborhood Hits	164	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

RAPH1_HUMAN
θ value	0.0330416 (rank : 982)	NC score	0.044886 (rank : 1186)
Query Neighborhood Hits	1804	Target Neighborhood Hits	593	Shared Neighborhood Hits	220
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RP1L1_HUMAN
θ value	0.0330416 (rank : 983)	NC score	0.064677 (rank : 1003)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1072	Shared Neighborhood Hits	332
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

RRBP1_HUMAN
θ value	0.0330416 (rank : 984)	NC score	0.034894 (rank : 1260)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1306	Shared Neighborhood Hits	223
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SFR16_HUMAN
θ value	0.0330416 (rank : 985)	NC score	0.039584 (rank : 1223)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

SRPK2_HUMAN
θ value	0.0330416 (rank : 986)	NC score	0.535654 (rank : 812)
Query Neighborhood Hits	1804	Target Neighborhood Hits	664	Shared Neighborhood Hits	584
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	0.0330416 (rank : 987)	NC score	0.533133 (rank : 814)
Query Neighborhood Hits	1804	Target Neighborhood Hits	765	Shared Neighborhood Hits	597
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_HUMAN
θ value	0.0330416 (rank : 988)	NC score	0.532304 (rank : 816)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	552
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	0.0330416 (rank : 989)	NC score	0.533182 (rank : 813)
Query Neighborhood Hits	1804	Target Neighborhood Hits	572	Shared Neighborhood Hits	559
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SYN1_HUMAN
θ value	0.0330416 (rank : 990)	NC score	0.046714 (rank : 1167)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	198
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

TGON2_HUMAN
θ value	0.0330416 (rank : 991)	NC score	0.097415 (rank : 895)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	389
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

THOC2_HUMAN
θ value	0.0330416 (rank : 992)	NC score	0.037107 (rank : 1242)
Query Neighborhood Hits	1804	Target Neighborhood Hits	337	Shared Neighborhood Hits	106
SwissProt Accessions	Q8NI27, Q9H8I6	Gene names	THOC2, CXorf3
Domain Architecture	No domain graphic available
Description	THO complex subunit 2 (Tho2).

ZO2_MOUSE
θ value	0.0330416 (rank : 993)	NC score	0.051337 (rank : 1116)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

AKA12_HUMAN
θ value	0.0431538 (rank : 994)	NC score	0.044385 (rank : 1190)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	209
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

ARI1B_HUMAN
θ value	0.0431538 (rank : 995)	NC score	0.049655 (rank : 1140)
Query Neighborhood Hits	1804	Target Neighborhood Hits	567	Shared Neighborhood Hits	231
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

BCLF1_MOUSE
θ value	0.0431538 (rank : 996)	NC score	0.043487 (rank : 1196)
Query Neighborhood Hits	1804	Target Neighborhood Hits	303	Shared Neighborhood Hits	105
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

COIA1_HUMAN
θ value	0.0431538 (rank : 997)	NC score	0.024328 (rank : 1395)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	158
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

DDX21_MOUSE
θ value	0.0431538 (rank : 998)	NC score	0.000675 (rank : 1749)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

ENL_HUMAN
θ value	0.0431538 (rank : 999)	NC score	0.045701 (rank : 1176)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	115
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

EPHAA_HUMAN
θ value	0.0431538 (rank : 1000)	NC score	0.547659 (rank : 807)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	753
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

GUC2D_HUMAN
θ value	0.0431538 (rank : 1001)	NC score	0.466413 (rank : 825)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	662
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2G_MOUSE
θ value	0.0431538 (rank : 1002)	NC score	0.445805 (rank : 829)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

INADL_MOUSE
θ value	0.0431538 (rank : 1003)	NC score	0.070448 (rank : 962)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	155
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

K2002_MOUSE
θ value	0.0431538 (rank : 1004)	NC score	0.309492 (rank : 844)
Query Neighborhood Hits	1804	Target Neighborhood Hits	267	Shared Neighborhood Hits	238
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MAP4_MOUSE
θ value	0.0431538 (rank : 1005)	NC score	0.064292 (rank : 1006)
Query Neighborhood Hits	1804	Target Neighborhood Hits	409	Shared Neighborhood Hits	189
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NU214_HUMAN
θ value	0.0431538 (rank : 1006)	NC score	0.056943 (rank : 1068)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	219
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PDLI4_MOUSE
θ value	0.0431538 (rank : 1007)	NC score	0.050985 (rank : 1124)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	108
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

REXO1_HUMAN
θ value	0.0431538 (rank : 1008)	NC score	0.033308 (rank : 1274)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RN5A_MOUSE
θ value	0.0431538 (rank : 1009)	NC score	0.337926 (rank : 841)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	621
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SPN90_MOUSE
θ value	0.0431538 (rank : 1010)	NC score	0.042828 (rank : 1199)
Query Neighborhood Hits	1804	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRCA_HUMAN
θ value	0.0431538 (rank : 1011)	NC score	0.024182 (rank : 1397)
Query Neighborhood Hits	1804	Target Neighborhood Hits	380	Shared Neighborhood Hits	123
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

SRPK1_HUMAN
θ value	0.0431538 (rank : 1012)	NC score	0.536734 (rank : 810)
Query Neighborhood Hits	1804	Target Neighborhood Hits	706	Shared Neighborhood Hits	593
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	0.0431538 (rank : 1013)	NC score	0.539150 (rank : 809)
Query Neighborhood Hits	1804	Target Neighborhood Hits	639	Shared Neighborhood Hits	575
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

TRDN_HUMAN
θ value	0.0431538 (rank : 1014)	NC score	0.044162 (rank : 1193)
Query Neighborhood Hits	1804	Target Neighborhood Hits	542	Shared Neighborhood Hits	117
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

TRIPC_HUMAN
θ value	0.0431538 (rank : 1015)	NC score	0.018238 (rank : 1484)
Query Neighborhood Hits	1804	Target Neighborhood Hits	319	Shared Neighborhood Hits	101
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

WIRE_MOUSE
θ value	0.0431538 (rank : 1016)	NC score	0.059231 (rank : 1050)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	145
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ZYX_HUMAN
θ value	0.0431538 (rank : 1017)	NC score	0.023104 (rank : 1415)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	106
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ADDA_MOUSE
θ value	0.0563607 (rank : 1018)	NC score	0.022904 (rank : 1418)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	103
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

GA2L1_HUMAN
θ value	0.0563607 (rank : 1019)	NC score	0.027998 (rank : 1335)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	87
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

GRIN1_MOUSE
θ value	0.0563607 (rank : 1020)	NC score	0.064577 (rank : 1004)
Query Neighborhood Hits	1804	Target Neighborhood Hits	337	Shared Neighborhood Hits	170
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

GUC2E_MOUSE
θ value	0.0563607 (rank : 1021)	NC score	0.442602 (rank : 830)
Query Neighborhood Hits	1804	Target Neighborhood Hits	692	Shared Neighborhood Hits	638
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

HMX3_MOUSE
θ value	0.0563607 (rank : 1022)	NC score	-0.010621 (rank : 1850)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	25
SwissProt Accessions	P42581	Gene names	Hmx3, Nkx-5.1, Nkx5-1
Domain Architecture
Description	Homeobox protein HMX3 (Homeobox protein Nkx-5.1).

HN1L_HUMAN
θ value	0.0563607 (rank : 1023)	NC score	0.028298 (rank : 1330)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

MUCDL_HUMAN
θ value	0.0563607 (rank : 1024)	NC score	0.046612 (rank : 1169)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	285
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PI3R4_HUMAN
θ value	0.0563607 (rank : 1025)	NC score	0.382033 (rank : 839)
Query Neighborhood Hits	1804	Target Neighborhood Hits	534	Shared Neighborhood Hits	359
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PO6F2_HUMAN
θ value	0.0563607 (rank : 1026)	NC score	0.006775 (rank : 1647)
Query Neighborhood Hits	1804	Target Neighborhood Hits	618	Shared Neighborhood Hits	135
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

PTN13_HUMAN
θ value	0.0563607 (rank : 1027)	NC score	0.026233 (rank : 1369)
Query Neighborhood Hits	1804	Target Neighborhood Hits	471	Shared Neighborhood Hits	176
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

SMOO_HUMAN
θ value	0.0563607 (rank : 1028)	NC score	0.040592 (rank : 1218)
Query Neighborhood Hits	1804	Target Neighborhood Hits	391	Shared Neighborhood Hits	166
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

ANPRA_MOUSE
θ value	0.0736092 (rank : 1029)	NC score	0.426965 (rank : 834)
Query Neighborhood Hits	1804	Target Neighborhood Hits	600	Shared Neighborhood Hits	538
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

CAF1B_MOUSE
θ value	0.0736092 (rank : 1030)	NC score	-0.001461 (rank : 1780)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

CRTC1_MOUSE
θ value	0.0736092 (rank : 1031)	NC score	0.031436 (rank : 1291)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	110
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

HMGA2_MOUSE
θ value	0.0736092 (rank : 1032)	NC score	0.030719 (rank : 1299)
Query Neighborhood Hits	1804	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P52927, Q3UQW0	Gene names	Hmga2, Hmgic
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

IQEC2_HUMAN
θ value	0.0736092 (rank : 1033)	NC score	0.022363 (rank : 1423)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	134
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	0.0736092 (rank : 1034)	NC score	0.021782 (rank : 1429)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	139
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IWS1_HUMAN
θ value	0.0736092 (rank : 1035)	NC score	0.064555 (rank : 1005)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1241	Shared Neighborhood Hits	361
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LNX2_HUMAN
θ value	0.0736092 (rank : 1036)	NC score	0.045942 (rank : 1172)
Query Neighborhood Hits	1804	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

MAGE1_HUMAN
θ value	0.0736092 (rank : 1037)	NC score	0.074431 (rank : 948)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1389	Shared Neighborhood Hits	493
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MLL4_HUMAN
θ value	0.0736092 (rank : 1038)	NC score	0.039169 (rank : 1224)
Query Neighborhood Hits	1804	Target Neighborhood Hits	722	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MTR1L_HUMAN
θ value	0.0736092 (rank : 1039)	NC score	-0.017390 (rank : 1869)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1180	Shared Neighborhood Hits	140
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

PDZD7_HUMAN
θ value	0.0736092 (rank : 1040)	NC score	0.072014 (rank : 956)
Query Neighborhood Hits	1804	Target Neighborhood Hits	181	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

PGCB_HUMAN
θ value	0.0736092 (rank : 1041)	NC score	0.000074 (rank : 1754)
Query Neighborhood Hits	1804	Target Neighborhood Hits	478	Shared Neighborhood Hits	79
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

PI3R4_MOUSE
θ value	0.0736092 (rank : 1042)	NC score	0.391837 (rank : 838)
Query Neighborhood Hits	1804	Target Neighborhood Hits	535	Shared Neighborhood Hits	367
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PRB3_HUMAN
θ value	0.0736092 (rank : 1043)	NC score	0.072470 (rank : 953)
Query Neighborhood Hits	1804	Target Neighborhood Hits	318	Shared Neighborhood Hits	145
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

SETX_HUMAN
θ value	0.0736092 (rank : 1044)	NC score	0.026921 (rank : 1356)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	124
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SMBP2_MOUSE
θ value	0.0736092 (rank : 1045)	NC score	0.011767 (rank : 1581)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

SSH1_MOUSE
θ value	0.0736092 (rank : 1046)	NC score	0.003823 (rank : 1690)
Query Neighborhood Hits	1804	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

ZYX_MOUSE
θ value	0.0736092 (rank : 1047)	NC score	0.023385 (rank : 1404)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	100
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ANPRA_HUMAN
θ value	0.0961366 (rank : 1048)	NC score	0.428525 (rank : 832)
Query Neighborhood Hits	1804	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

CAC1G_HUMAN
θ value	0.0961366 (rank : 1049)	NC score	0.025040 (rank : 1386)
Query Neighborhood Hits	1804	Target Neighborhood Hits	587	Shared Neighborhood Hits	242
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CO2A1_MOUSE
θ value	0.0961366 (rank : 1050)	NC score	0.014203 (rank : 1548)
Query Neighborhood Hits	1804	Target Neighborhood Hits	483	Shared Neighborhood Hits	132
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CTDP1_MOUSE
θ value	0.0961366 (rank : 1051)	NC score	0.019721 (rank : 1460)
Query Neighborhood Hits	1804	Target Neighborhood Hits	146	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DIDO1_HUMAN
θ value	0.0961366 (rank : 1052)	NC score	0.061308 (rank : 1028)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	334
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

FOXD2_MOUSE
θ value	0.0961366 (rank : 1053)	NC score	-0.001203 (rank : 1777)
Query Neighborhood Hits	1804	Target Neighborhood Hits	130	Shared Neighborhood Hits	34
SwissProt Accessions	O35392	Gene names	Foxd2, Mf2
Domain Architecture
Description	Forkhead box protein D2 (Mesoderm/mesenchyme forkhead 2) (MF-2).

K1543_HUMAN
θ value	0.0961366 (rank : 1054)	NC score	0.056588 (rank : 1072)
Query Neighborhood Hits	1804	Target Neighborhood Hits	435	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1543_MOUSE
θ value	0.0961366 (rank : 1055)	NC score	0.062710 (rank : 1018)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	229
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MBD6_HUMAN
θ value	0.0961366 (rank : 1056)	NC score	0.061637 (rank : 1024)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	159
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MY18A_MOUSE
θ value	0.0961366 (rank : 1057)	NC score	0.050603 (rank : 1126)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1989	Shared Neighborhood Hits	344
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PO121_HUMAN
θ value	0.0961366 (rank : 1058)	NC score	0.045203 (rank : 1181)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

SNPC4_HUMAN
θ value	0.0961366 (rank : 1059)	NC score	0.059327 (rank : 1049)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	261
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SNTG2_HUMAN
θ value	0.0961366 (rank : 1060)	NC score	0.052000 (rank : 1107)
Query Neighborhood Hits	1804	Target Neighborhood Hits	191	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SSH3_HUMAN
θ value	0.0961366 (rank : 1061)	NC score	0.002990 (rank : 1708)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

TAU_MOUSE
θ value	0.0961366 (rank : 1062)	NC score	0.075108 (rank : 944)
Query Neighborhood Hits	1804	Target Neighborhood Hits	502	Shared Neighborhood Hits	242
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TGFR2_HUMAN
θ value	0.0961366 (rank : 1063)	NC score	0.668672 (rank : 690)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	738
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	0.0961366 (rank : 1064)	NC score	0.667775 (rank : 694)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	739
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

VRK1_MOUSE
θ value	0.0961366 (rank : 1065)	NC score	0.477076 (rank : 822)
Query Neighborhood Hits	1804	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

BAI1_HUMAN
θ value	0.125558 (rank : 1066)	NC score	-0.000533 (rank : 1767)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	83
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CO039_HUMAN
θ value	0.125558 (rank : 1067)	NC score	0.042463 (rank : 1203)
Query Neighborhood Hits	1804	Target Neighborhood Hits	264	Shared Neighborhood Hits	132
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CTR9_MOUSE
θ value	0.125558 (rank : 1068)	NC score	0.019571 (rank : 1461)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	86
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

GP156_HUMAN
θ value	0.125558 (rank : 1069)	NC score	0.011498 (rank : 1587)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

H15_HUMAN
θ value	0.125558 (rank : 1070)	NC score	0.017711 (rank : 1489)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	P16401, Q14529	Gene names	HIST1H1B, H1F5
Domain Architecture
Description	Histone H1.5 (Histone H1a).

MAP1B_HUMAN
θ value	0.125558 (rank : 1071)	NC score	0.047201 (rank : 1163)
Query Neighborhood Hits	1804	Target Neighborhood Hits	903	Shared Neighborhood Hits	246
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MBB1A_HUMAN
θ value	0.125558 (rank : 1072)	NC score	0.072837 (rank : 952)
Query Neighborhood Hits	1804	Target Neighborhood Hits	665	Shared Neighborhood Hits	301
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MLL3_MOUSE
θ value	0.125558 (rank : 1073)	NC score	0.067242 (rank : 983)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1399	Shared Neighborhood Hits	413
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NPBL_MOUSE
θ value	0.125558 (rank : 1074)	NC score	0.064713 (rank : 1002)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1041	Shared Neighborhood Hits	332
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PANK1_HUMAN
θ value	0.125558 (rank : 1075)	NC score	0.006542 (rank : 1651)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TE04, Q7RTX6, Q7Z495, Q8TBQ8	Gene names	PANK1, PANK
Domain Architecture
Description	Pantothenate kinase 1 (EC 2.7.1.33) (Pantothenic acid kinase 1) (hPanK1) (hPanK).

PHC1_HUMAN
θ value	0.125558 (rank : 1076)	NC score	0.033144 (rank : 1275)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	94
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

PPRB_MOUSE
θ value	0.125558 (rank : 1077)	NC score	0.049611 (rank : 1143)
Query Neighborhood Hits	1804	Target Neighborhood Hits	354	Shared Neighborhood Hits	159
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

PRP2_MOUSE
θ value	0.125558 (rank : 1078)	NC score	0.068490 (rank : 972)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	150
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR8_HUMAN
θ value	0.125558 (rank : 1079)	NC score	0.045458 (rank : 1179)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RFIP1_MOUSE
θ value	0.125558 (rank : 1080)	NC score	0.023335 (rank : 1405)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RPGF2_HUMAN
θ value	0.125558 (rank : 1081)	NC score	0.041921 (rank : 1209)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

SDCB2_MOUSE
θ value	0.125558 (rank : 1082)	NC score	0.040604 (rank : 1217)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	84
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

ZIMP7_HUMAN
θ value	0.125558 (rank : 1083)	NC score	0.016957 (rank : 1503)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	110
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZN318_HUMAN
θ value	0.125558 (rank : 1084)	NC score	0.027536 (rank : 1342)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	121
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ADA2A_MOUSE
θ value	0.163984 (rank : 1085)	NC score	-0.025133 (rank : 1881)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	32
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

BCL7C_MOUSE
θ value	0.163984 (rank : 1086)	NC score	0.016553 (rank : 1509)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	69
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

CO3A1_MOUSE
θ value	0.163984 (rank : 1087)	NC score	0.023296 (rank : 1407)
Query Neighborhood Hits	1804	Target Neighborhood Hits	466	Shared Neighborhood Hits	152
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CUTL1_HUMAN
θ value	0.163984 (rank : 1088)	NC score	0.027462 (rank : 1345)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1574	Shared Neighborhood Hits	261
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CYTSA_HUMAN
θ value	0.163984 (rank : 1089)	NC score	0.026698 (rank : 1361)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1138	Shared Neighborhood Hits	173
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

FBX41_MOUSE
θ value	0.163984 (rank : 1090)	NC score	0.024746 (rank : 1389)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

GGN_MOUSE
θ value	0.163984 (rank : 1091)	NC score	0.051090 (rank : 1122)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	129
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GRIP1_HUMAN
θ value	0.163984 (rank : 1092)	NC score	0.063158 (rank : 1013)
Query Neighborhood Hits	1804	Target Neighborhood Hits	231	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

GRIP1_MOUSE
θ value	0.163984 (rank : 1093)	NC score	0.060929 (rank : 1034)
Query Neighborhood Hits	1804	Target Neighborhood Hits	241	Shared Neighborhood Hits	140
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

HNRL1_HUMAN
θ value	0.163984 (rank : 1094)	NC score	0.019463 (rank : 1464)
Query Neighborhood Hits	1804	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

INP5E_HUMAN
θ value	0.163984 (rank : 1095)	NC score	0.029867 (rank : 1308)
Query Neighborhood Hits	1804	Target Neighborhood Hits	201	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

LNX2_MOUSE
θ value	0.163984 (rank : 1096)	NC score	0.045018 (rank : 1185)
Query Neighborhood Hits	1804	Target Neighborhood Hits	407	Shared Neighborhood Hits	136
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

MAP1A_HUMAN
θ value	0.163984 (rank : 1097)	NC score	0.068919 (rank : 969)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1626	Shared Neighborhood Hits	429
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NCOA6_HUMAN
θ value	0.163984 (rank : 1098)	NC score	0.094314 (rank : 901)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1202	Shared Neighborhood Hits	475
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NFAC2_HUMAN
θ value	0.163984 (rank : 1099)	NC score	0.009974 (rank : 1609)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

PDZD2_HUMAN
θ value	0.163984 (rank : 1100)	NC score	0.091682 (rank : 907)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	372
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PO6F2_MOUSE
θ value	0.163984 (rank : 1101)	NC score	0.010557 (rank : 1596)
Query Neighborhood Hits	1804	Target Neighborhood Hits	639	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PRR12_HUMAN
θ value	0.163984 (rank : 1102)	NC score	0.061789 (rank : 1022)
Query Neighborhood Hits	1804	Target Neighborhood Hits	460	Shared Neighborhood Hits	188
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RBBP6_HUMAN
θ value	0.163984 (rank : 1103)	NC score	0.048953 (rank : 1149)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1135	Shared Neighborhood Hits	265
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RN5A_HUMAN
θ value	0.163984 (rank : 1104)	NC score	0.168215 (rank : 850)
Query Neighborhood Hits	1804	Target Neighborhood Hits	608	Shared Neighborhood Hits	346
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ROBO3_MOUSE
θ value	0.163984 (rank : 1105)	NC score	0.043844 (rank : 1195)
Query Neighborhood Hits	1804	Target Neighborhood Hits	524	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

SC24D_HUMAN
θ value	0.163984 (rank : 1106)	NC score	0.023669 (rank : 1401)
Query Neighborhood Hits	1804	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

SDCB2_HUMAN
θ value	0.163984 (rank : 1107)	NC score	0.045561 (rank : 1177)
Query Neighborhood Hits	1804	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SI1L3_HUMAN
θ value	0.163984 (rank : 1108)	NC score	0.026968 (rank : 1354)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	150
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SYJ2B_HUMAN
θ value	0.163984 (rank : 1109)	NC score	0.065196 (rank : 997)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	111
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

TCF20_HUMAN
θ value	0.163984 (rank : 1110)	NC score	0.031172 (rank : 1296)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TENS1_HUMAN
θ value	0.163984 (rank : 1111)	NC score	0.044801 (rank : 1187)
Query Neighborhood Hits	1804	Target Neighborhood Hits	400	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TUB_HUMAN
θ value	0.163984 (rank : 1112)	NC score	0.007176 (rank : 1643)
Query Neighborhood Hits	1804	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	P50607, O00293	Gene names	TUB
Domain Architecture
Description	Tubby protein homolog.

WASF2_MOUSE
θ value	0.163984 (rank : 1113)	NC score	0.033813 (rank : 1271)
Query Neighborhood Hits	1804	Target Neighborhood Hits	315	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

YLPM1_MOUSE
θ value	0.163984 (rank : 1114)	NC score	0.049270 (rank : 1148)
Query Neighborhood Hits	1804	Target Neighborhood Hits	505	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ZN142_HUMAN
θ value	0.163984 (rank : 1115)	NC score	-0.021833 (rank : 1875)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1007	Shared Neighborhood Hits	145
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZO1_MOUSE
θ value	0.163984 (rank : 1116)	NC score	0.050720 (rank : 1125)
Query Neighborhood Hits	1804	Target Neighborhood Hits	453	Shared Neighborhood Hits	205
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ACINU_MOUSE
θ value	0.21417 (rank : 1117)	NC score	0.049351 (rank : 1146)
Query Neighborhood Hits	1804	Target Neighborhood Hits	712	Shared Neighborhood Hits	198
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ADDA_HUMAN
θ value	0.21417 (rank : 1118)	NC score	0.013431 (rank : 1563)
Query Neighborhood Hits	1804	Target Neighborhood Hits	108	Shared Neighborhood Hits	43
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

ARHGF_HUMAN
θ value	0.21417 (rank : 1119)	NC score	0.023533 (rank : 1402)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

CBP_HUMAN
θ value	0.21417 (rank : 1120)	NC score	0.057950 (rank : 1061)
Query Neighborhood Hits	1804	Target Neighborhood Hits	941	Shared Neighborhood Hits	356
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCD1A_MOUSE
θ value	0.21417 (rank : 1121)	NC score	0.012660 (rank : 1573)
Query Neighborhood Hits	1804	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K1A6, Q2MJB5, Q8R3Z4	Gene names	Cc2d1a
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1).

CF150_HUMAN
θ value	0.21417 (rank : 1122)	NC score	0.037853 (rank : 1236)
Query Neighborhood Hits	1804	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

CO1A1_MOUSE
θ value	0.21417 (rank : 1123)	NC score	0.025118 (rank : 1384)
Query Neighborhood Hits	1804	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO7A1_HUMAN
θ value	0.21417 (rank : 1124)	NC score	0.020165 (rank : 1453)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	217
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

DOK1_HUMAN
θ value	0.21417 (rank : 1125)	NC score	0.010933 (rank : 1594)
Query Neighborhood Hits	1804	Target Neighborhood Hits	85	Shared Neighborhood Hits	39
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

HNRL1_MOUSE
θ value	0.21417 (rank : 1126)	NC score	0.019989 (rank : 1455)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

IKBE_HUMAN
θ value	0.21417 (rank : 1127)	NC score	0.017126 (rank : 1501)
Query Neighborhood Hits	1804	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

LAP4_MOUSE
θ value	0.21417 (rank : 1128)	NC score	0.037414 (rank : 1240)
Query Neighborhood Hits	1804	Target Neighborhood Hits	590	Shared Neighborhood Hits	188
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LNX1_HUMAN
θ value	0.21417 (rank : 1129)	NC score	0.049336 (rank : 1147)
Query Neighborhood Hits	1804	Target Neighborhood Hits	379	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

MY18A_HUMAN
θ value	0.21417 (rank : 1130)	NC score	0.048825 (rank : 1153)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1929	Shared Neighborhood Hits	313
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NFAC4_HUMAN
θ value	0.21417 (rank : 1131)	NC score	0.015927 (rank : 1522)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

RGS3_MOUSE
θ value	0.21417 (rank : 1132)	NC score	0.097038 (rank : 896)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1621	Shared Neighborhood Hits	618
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RTN1_MOUSE
θ value	0.21417 (rank : 1133)	NC score	0.021483 (rank : 1431)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SREC2_HUMAN
θ value	0.21417 (rank : 1134)	NC score	0.011607 (rank : 1585)
Query Neighborhood Hits	1804	Target Neighborhood Hits	645	Shared Neighborhood Hits	136
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

TACC2_HUMAN
θ value	0.21417 (rank : 1135)	NC score	0.048131 (rank : 1159)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	214
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TXND2_HUMAN
θ value	0.21417 (rank : 1136)	NC score	0.085927 (rank : 916)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	301
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

WASL_MOUSE
θ value	0.21417 (rank : 1137)	NC score	0.050987 (rank : 1123)
Query Neighborhood Hits	1804	Target Neighborhood Hits	339	Shared Neighborhood Hits	156
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

XPC_MOUSE
θ value	0.21417 (rank : 1138)	NC score	0.012843 (rank : 1570)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	P51612, P54732, Q3TKI2, Q920M1, Q9DBW7	Gene names	Xpc
Domain Architecture
Description	DNA-repair protein complementing XP-C cells homolog (Xeroderma pigmentosum group C-complementing protein homolog) (p125).

ZN217_HUMAN
θ value	0.21417 (rank : 1139)	NC score	-0.017357 (rank : 1868)
Query Neighborhood Hits	1804	Target Neighborhood Hits	905	Shared Neighborhood Hits	141
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

ARHGG_MOUSE
θ value	0.279714 (rank : 1140)	NC score	0.006308 (rank : 1657)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	25
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARMX2_HUMAN
θ value	0.279714 (rank : 1141)	NC score	0.016055 (rank : 1520)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

CP053_MOUSE
θ value	0.279714 (rank : 1142)	NC score	0.014597 (rank : 1541)
Query Neighborhood Hits	1804	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q99L02	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53 homolog.

CSPG3_HUMAN
θ value	0.279714 (rank : 1143)	NC score	0.000195 (rank : 1751)
Query Neighborhood Hits	1804	Target Neighborhood Hits	676	Shared Neighborhood Hits	130
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DAB2P_MOUSE
θ value	0.279714 (rank : 1144)	NC score	0.014620 (rank : 1540)
Query Neighborhood Hits	1804	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

DLG2_HUMAN
θ value	0.279714 (rank : 1145)	NC score	0.050180 (rank : 1134)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	138
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG4_HUMAN
θ value	0.279714 (rank : 1146)	NC score	0.054583 (rank : 1083)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	149
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
θ value	0.279714 (rank : 1147)	NC score	0.053895 (rank : 1090)
Query Neighborhood Hits	1804	Target Neighborhood Hits	282	Shared Neighborhood Hits	146
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

EP400_HUMAN
θ value	0.279714 (rank : 1148)	NC score	0.020889 (rank : 1443)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	180
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

FOG1_HUMAN
θ value	0.279714 (rank : 1149)	NC score	-0.010701 (rank : 1852)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	162
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

IQEC3_MOUSE
θ value	0.279714 (rank : 1150)	NC score	0.019807 (rank : 1459)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	112
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

K1688_HUMAN
θ value	0.279714 (rank : 1151)	NC score	0.021041 (rank : 1438)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	96
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

KCNA5_HUMAN
θ value	0.279714 (rank : 1152)	NC score	-0.003961 (rank : 1809)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

PDZD8_HUMAN
θ value	0.279714 (rank : 1153)	NC score	0.141142 (rank : 852)
Query Neighborhood Hits	1804	Target Neighborhood Hits	185	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PHAR2_HUMAN
θ value	0.279714 (rank : 1154)	NC score	0.030720 (rank : 1298)
Query Neighborhood Hits	1804	Target Neighborhood Hits	208	Shared Neighborhood Hits	85
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

PRRT3_HUMAN
θ value	0.279714 (rank : 1155)	NC score	0.097670 (rank : 892)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	427
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RBBP6_MOUSE
θ value	0.279714 (rank : 1156)	NC score	0.059617 (rank : 1047)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1014	Shared Neighborhood Hits	262
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RIN3_HUMAN
θ value	0.279714 (rank : 1157)	NC score	0.021919 (rank : 1427)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

SYV_HUMAN
θ value	0.279714 (rank : 1158)	NC score	0.006401 (rank : 1655)
Query Neighborhood Hits	1804	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

TOPK_MOUSE
θ value	0.279714 (rank : 1159)	NC score	0.590518 (rank : 798)
Query Neighborhood Hits	1804	Target Neighborhood Hits	618	Shared Neighborhood Hits	605
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

ZFP91_HUMAN
θ value	0.279714 (rank : 1160)	NC score	-0.023737 (rank : 1877)
Query Neighborhood Hits	1804	Target Neighborhood Hits	769	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

ANR25_MOUSE
θ value	0.365318 (rank : 1161)	NC score	0.019111 (rank : 1467)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ATS19_HUMAN
θ value	0.365318 (rank : 1162)	NC score	-0.004513 (rank : 1813)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

CO1A1_HUMAN
θ value	0.365318 (rank : 1163)	NC score	0.023259 (rank : 1409)
Query Neighborhood Hits	1804	Target Neighborhood Hits	475	Shared Neighborhood Hits	145
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CS007_MOUSE
θ value	0.365318 (rank : 1164)	NC score	0.042311 (rank : 1204)
Query Neighborhood Hits	1804	Target Neighborhood Hits	464	Shared Neighborhood Hits	188
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DLG2_MOUSE
θ value	0.365318 (rank : 1165)	NC score	0.049642 (rank : 1141)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	136
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

DLG5_HUMAN
θ value	0.365318 (rank : 1166)	NC score	0.057926 (rank : 1062)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	286
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DLX2_HUMAN
θ value	0.365318 (rank : 1167)	NC score	-0.011216 (rank : 1855)
Query Neighborhood Hits	1804	Target Neighborhood Hits	355	Shared Neighborhood Hits	28
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

ELOA3_HUMAN
θ value	0.365318 (rank : 1168)	NC score	0.022987 (rank : 1416)
Query Neighborhood Hits	1804	Target Neighborhood Hits	98	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

ERCC5_MOUSE
θ value	0.365318 (rank : 1169)	NC score	0.018774 (rank : 1476)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	66
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

FA21C_HUMAN
θ value	0.365318 (rank : 1170)	NC score	0.025222 (rank : 1380)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

FOXD2_HUMAN
θ value	0.365318 (rank : 1171)	NC score	-0.001490 (rank : 1781)
Query Neighborhood Hits	1804	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

GA2L3_HUMAN
θ value	0.365318 (rank : 1172)	NC score	0.033709 (rank : 1272)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	98
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

HASP_MOUSE
θ value	0.365318 (rank : 1173)	NC score	0.026578 (rank : 1363)
Query Neighborhood Hits	1804	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z0R0, Q99MU9, Q9JJJ4	Gene names	Gsg2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (Germ cell-specific gene 2 protein).

HXD10_HUMAN
θ value	0.365318 (rank : 1174)	NC score	-0.009576 (rank : 1844)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	P28358	Gene names	HOXD10, HOX4D
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4D) (Hox-4E).

IF4B_HUMAN
θ value	0.365318 (rank : 1175)	NC score	0.034768 (rank : 1261)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	159
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

K2027_MOUSE
θ value	0.365318 (rank : 1176)	NC score	0.028969 (rank : 1323)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BWS5, Q69Z30	Gene names	Kiaa2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

LNX1_MOUSE
θ value	0.365318 (rank : 1177)	NC score	0.047153 (rank : 1164)
Query Neighborhood Hits	1804	Target Neighborhood Hits	377	Shared Neighborhood Hits	124
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

MINT_HUMAN
θ value	0.365318 (rank : 1178)	NC score	0.054255 (rank : 1086)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1291	Shared Neighborhood Hits	357
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NTBP1_MOUSE
θ value	0.365318 (rank : 1179)	NC score	0.035678 (rank : 1252)
Query Neighborhood Hits	1804	Target Neighborhood Hits	528	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

PDLI2_HUMAN
θ value	0.365318 (rank : 1180)	NC score	0.060354 (rank : 1040)
Query Neighborhood Hits	1804	Target Neighborhood Hits	245	Shared Neighborhood Hits	113
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

PP1RA_MOUSE
θ value	0.365318 (rank : 1181)	NC score	0.021054 (rank : 1437)
Query Neighborhood Hits	1804	Target Neighborhood Hits	175	Shared Neighborhood Hits	76
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

PTN13_MOUSE
θ value	0.365318 (rank : 1182)	NC score	0.027578 (rank : 1340)
Query Neighborhood Hits	1804	Target Neighborhood Hits	426	Shared Neighborhood Hits	161
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RP3A_MOUSE
θ value	0.365318 (rank : 1183)	NC score	0.041627 (rank : 1210)
Query Neighborhood Hits	1804	Target Neighborhood Hits	510	Shared Neighborhood Hits	206
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYGP1_HUMAN
θ value	0.365318 (rank : 1184)	NC score	0.017298 (rank : 1498)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	88
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

TUB_MOUSE
θ value	0.365318 (rank : 1185)	NC score	0.007187 (rank : 1642)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	P50586	Gene names	Tub, Rd5
Domain Architecture
Description	Tubby protein.

ADA19_MOUSE
θ value	0.47712 (rank : 1186)	NC score	-0.004662 (rank : 1814)
Query Neighborhood Hits	1804	Target Neighborhood Hits	315	Shared Neighborhood Hits	50
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

ADA29_HUMAN
θ value	0.47712 (rank : 1187)	NC score	-0.001806 (rank : 1785)
Query Neighborhood Hits	1804	Target Neighborhood Hits	247	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ANKS1_HUMAN
θ value	0.47712 (rank : 1188)	NC score	0.028119 (rank : 1332)
Query Neighborhood Hits	1804	Target Neighborhood Hits	438	Shared Neighborhood Hits	95
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

APBA2_HUMAN
θ value	0.47712 (rank : 1189)	NC score	0.048536 (rank : 1155)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	123
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.47712 (rank : 1190)	NC score	0.048901 (rank : 1151)
Query Neighborhood Hits	1804	Target Neighborhood Hits	219	Shared Neighborhood Hits	122
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

ASPP2_HUMAN
θ value	0.47712 (rank : 1191)	NC score	0.051618 (rank : 1111)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1156	Shared Neighborhood Hits	276
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BIN1_MOUSE
θ value	0.47712 (rank : 1192)	NC score	0.019512 (rank : 1462)
Query Neighborhood Hits	1804	Target Neighborhood Hits	283	Shared Neighborhood Hits	91
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CO8A1_HUMAN
θ value	0.47712 (rank : 1193)	NC score	0.010251 (rank : 1605)
Query Neighborhood Hits	1804	Target Neighborhood Hits	288	Shared Neighborhood Hits	91
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

COBA1_MOUSE
θ value	0.47712 (rank : 1194)	NC score	0.014372 (rank : 1546)
Query Neighborhood Hits	1804	Target Neighborhood Hits	487	Shared Neighborhood Hits	144
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

DDEF2_HUMAN
θ value	0.47712 (rank : 1195)	NC score	0.010287 (rank : 1602)
Query Neighborhood Hits	1804	Target Neighborhood Hits	599	Shared Neighborhood Hits	120
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DLG7_HUMAN
θ value	0.47712 (rank : 1196)	NC score	0.010435 (rank : 1599)
Query Neighborhood Hits	1804	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	Q15398, Q8NG58	Gene names	DLG7, KIAA0008
Domain Architecture
Description	Discs large homolog 7 (Hepatoma up-regulated protein) (HURP).

DLX2_MOUSE
θ value	0.47712 (rank : 1197)	NC score	-0.011700 (rank : 1856)
Query Neighborhood Hits	1804	Target Neighborhood Hits	352	Shared Neighborhood Hits	24
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

GRIP2_HUMAN
θ value	0.47712 (rank : 1198)	NC score	0.063367 (rank : 1010)
Query Neighborhood Hits	1804	Target Neighborhood Hits	256	Shared Neighborhood Hits	144
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

H14_MOUSE
θ value	0.47712 (rank : 1199)	NC score	0.016572 (rank : 1506)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	P43274	Gene names	Hist1h1e, H1f4
Domain Architecture
Description	Histone H1.4 (H1 VAR.2) (H1e).

IRS2_MOUSE
θ value	0.47712 (rank : 1200)	NC score	0.029268 (rank : 1316)
Query Neighborhood Hits	1804	Target Neighborhood Hits	248	Shared Neighborhood Hits	102
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

LIN7B_HUMAN
θ value	0.47712 (rank : 1201)	NC score	0.055470 (rank : 1079)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

MUC7_HUMAN
θ value	0.47712 (rank : 1202)	NC score	0.067298 (rank : 982)
Query Neighborhood Hits	1804	Target Neighborhood Hits	538	Shared Neighborhood Hits	213
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MYC_HUMAN
θ value	0.47712 (rank : 1203)	NC score	0.006644 (rank : 1650)
Query Neighborhood Hits	1804	Target Neighborhood Hits	146	Shared Neighborhood Hits	29
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

PDC6I_MOUSE
θ value	0.47712 (rank : 1204)	NC score	0.022309 (rank : 1424)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	92
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

RANB9_HUMAN
θ value	0.47712 (rank : 1205)	NC score	0.020072 (rank : 1454)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	81
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

RUNX3_HUMAN
θ value	0.47712 (rank : 1206)	NC score	0.018979 (rank : 1471)
Query Neighborhood Hits	1804	Target Neighborhood Hits	96	Shared Neighborhood Hits	45
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

RXRB_MOUSE
θ value	0.47712 (rank : 1207)	NC score	-0.005421 (rank : 1816)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	53
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

SAM14_HUMAN
θ value	0.47712 (rank : 1208)	NC score	0.018590 (rank : 1480)
Query Neighborhood Hits	1804	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SAM14_MOUSE
θ value	0.47712 (rank : 1209)	NC score	0.018406 (rank : 1482)
Query Neighborhood Hits	1804	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SDCB1_HUMAN
θ value	0.47712 (rank : 1210)	NC score	0.045018 (rank : 1184)
Query Neighborhood Hits	1804	Target Neighborhood Hits	150	Shared Neighborhood Hits	103
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

SDCB1_MOUSE
θ value	0.47712 (rank : 1211)	NC score	0.046393 (rank : 1170)
Query Neighborhood Hits	1804	Target Neighborhood Hits	144	Shared Neighborhood Hits	101
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

SEM6C_MOUSE
θ value	0.47712 (rank : 1212)	NC score	0.003940 (rank : 1687)
Query Neighborhood Hits	1804	Target Neighborhood Hits	352	Shared Neighborhood Hits	136
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

TP53B_MOUSE
θ value	0.47712 (rank : 1213)	NC score	0.059933 (rank : 1044)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	247
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TXND2_MOUSE
θ value	0.47712 (rank : 1214)	NC score	0.045932 (rank : 1173)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	197
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

USH1C_HUMAN
θ value	0.47712 (rank : 1215)	NC score	0.072155 (rank : 955)
Query Neighborhood Hits	1804	Target Neighborhood Hits	327	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	0.47712 (rank : 1216)	NC score	0.075077 (rank : 945)
Query Neighborhood Hits	1804	Target Neighborhood Hits	557	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

ZIC5_HUMAN
θ value	0.47712 (rank : 1217)	NC score	-0.022848 (rank : 1876)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	66
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZN687_MOUSE
θ value	0.47712 (rank : 1218)	NC score	-0.014315 (rank : 1864)
Query Neighborhood Hits	1804	Target Neighborhood Hits	913	Shared Neighborhood Hits	142
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ZO2_HUMAN
θ value	0.47712 (rank : 1219)	NC score	0.050218 (rank : 1133)
Query Neighborhood Hits	1804	Target Neighborhood Hits	289	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ADA2A_HUMAN
θ value	0.62314 (rank : 1220)	NC score	-0.025329 (rank : 1883)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	33
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

AF17_HUMAN
θ value	0.62314 (rank : 1221)	NC score	0.015091 (rank : 1530)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	83
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

APC_HUMAN
θ value	0.62314 (rank : 1222)	NC score	0.038045 (rank : 1235)
Query Neighborhood Hits	1804	Target Neighborhood Hits	603	Shared Neighborhood Hits	187
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APXL_HUMAN
θ value	0.62314 (rank : 1223)	NC score	0.071695 (rank : 957)
Query Neighborhood Hits	1804	Target Neighborhood Hits	553	Shared Neighborhood Hits	248
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

CCDC4_HUMAN
θ value	0.62314 (rank : 1224)	NC score	0.023219 (rank : 1412)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CELR1_MOUSE
θ value	0.62314 (rank : 1225)	NC score	-0.013152 (rank : 1860)
Query Neighborhood Hits	1804	Target Neighborhood Hits	617	Shared Neighborhood Hits	52
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

CSPG5_HUMAN
θ value	0.62314 (rank : 1226)	NC score	0.022955 (rank : 1417)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	82
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

CSPG5_MOUSE
θ value	0.62314 (rank : 1227)	NC score	0.029910 (rank : 1306)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	81
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

FOG1_MOUSE
θ value	0.62314 (rank : 1228)	NC score	-0.002544 (rank : 1798)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1237	Shared Neighborhood Hits	297
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GAB2_MOUSE
θ value	0.62314 (rank : 1229)	NC score	0.019086 (rank : 1468)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GP153_HUMAN
θ value	0.62314 (rank : 1230)	NC score	-0.001390 (rank : 1778)
Query Neighborhood Hits	1804	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

GTR10_HUMAN
θ value	0.62314 (rank : 1231)	NC score	0.003579 (rank : 1697)
Query Neighborhood Hits	1804	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O95528, Q9H4I6	Gene names	SLC2A10, GLUT10
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10).

HXA10_HUMAN
θ value	0.62314 (rank : 1232)	NC score	-0.010840 (rank : 1854)
Query Neighborhood Hits	1804	Target Neighborhood Hits	334	Shared Neighborhood Hits	30
SwissProt Accessions	P31260, O43370, O43605, Q15949	Gene names	HOXA10, HOX1H
Domain Architecture
Description	Homeobox protein Hox-A10 (Hox-1H) (Hox-1.8) (PL).

HXD10_MOUSE
θ value	0.62314 (rank : 1233)	NC score	-0.009753 (rank : 1847)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	P28359, Q91WU9	Gene names	Hoxd10, Hox-4.5, Hoxd-10
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4.5) (Hox-5.3).

IL16_HUMAN
θ value	0.62314 (rank : 1234)	NC score	0.038674 (rank : 1232)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	118
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

INSM1_HUMAN
θ value	0.62314 (rank : 1235)	NC score	-0.018402 (rank : 1870)
Query Neighborhood Hits	1804	Target Neighborhood Hits	683	Shared Neighborhood Hits	50
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

IRS2_HUMAN
θ value	0.62314 (rank : 1236)	NC score	0.036068 (rank : 1250)
Query Neighborhood Hits	1804	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

JIP3_HUMAN
θ value	0.62314 (rank : 1237)	NC score	0.036717 (rank : 1245)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1039	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

K0460_MOUSE
θ value	0.62314 (rank : 1238)	NC score	0.029425 (rank : 1315)
Query Neighborhood Hits	1804	Target Neighborhood Hits	374	Shared Neighborhood Hits	138
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

KLH26_HUMAN
θ value	0.62314 (rank : 1239)	NC score	-0.010637 (rank : 1851)
Query Neighborhood Hits	1804	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	Q53HC5, Q8TAP0, Q9NUX3	Gene names	KLHL26
Domain Architecture	No domain graphic available
Description	Kelch-like protein 26.

LAD1_HUMAN
θ value	0.62314 (rank : 1240)	NC score	0.074061 (rank : 949)
Query Neighborhood Hits	1804	Target Neighborhood Hits	441	Shared Neighborhood Hits	197
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LAD1_MOUSE
θ value	0.62314 (rank : 1241)	NC score	0.070976 (rank : 958)
Query Neighborhood Hits	1804	Target Neighborhood Hits	391	Shared Neighborhood Hits	182
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LCP2_HUMAN
θ value	0.62314 (rank : 1242)	NC score	0.075975 (rank : 943)
Query Neighborhood Hits	1804	Target Neighborhood Hits	531	Shared Neighborhood Hits	251
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LRC50_HUMAN
θ value	0.62314 (rank : 1243)	NC score	0.005867 (rank : 1663)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

PP1RA_HUMAN
θ value	0.62314 (rank : 1244)	NC score	0.025540 (rank : 1375)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	85
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

RPB1_HUMAN
θ value	0.62314 (rank : 1245)	NC score	0.034150 (rank : 1267)
Query Neighborhood Hits	1804	Target Neighborhood Hits	362	Shared Neighborhood Hits	144
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.62314 (rank : 1246)	NC score	0.034981 (rank : 1258)
Query Neighborhood Hits	1804	Target Neighborhood Hits	363	Shared Neighborhood Hits	143
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SACS_HUMAN
θ value	0.62314 (rank : 1247)	NC score	0.004850 (rank : 1679)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

SEPT9_HUMAN
θ value	0.62314 (rank : 1248)	NC score	0.040259 (rank : 1221)
Query Neighborhood Hits	1804	Target Neighborhood Hits	706	Shared Neighborhood Hits	292
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SOS1_MOUSE
θ value	0.62314 (rank : 1249)	NC score	0.010274 (rank : 1603)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	78
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOX6_HUMAN
θ value	0.62314 (rank : 1250)	NC score	0.014595 (rank : 1542)
Query Neighborhood Hits	1804	Target Neighborhood Hits	332	Shared Neighborhood Hits	95
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

TENS4_HUMAN
θ value	0.62314 (rank : 1251)	NC score	0.034067 (rank : 1268)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TIRAP_MOUSE
θ value	0.62314 (rank : 1252)	NC score	0.007428 (rank : 1637)
Query Neighborhood Hits	1804	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JY1, Q91ZW0	Gene names	Tirap, Mal
Domain Architecture
Description	Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (MyD88 adapter-like protein) (Adaptor protein Wyatt).

UBN1_HUMAN
θ value	0.62314 (rank : 1253)	NC score	0.020476 (rank : 1450)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

ZMYM3_HUMAN
θ value	0.62314 (rank : 1254)	NC score	0.014911 (rank : 1534)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	69
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZO3_HUMAN
θ value	0.62314 (rank : 1255)	NC score	0.047382 (rank : 1162)
Query Neighborhood Hits	1804	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

BCL9_MOUSE
θ value	0.813845 (rank : 1256)	NC score	0.056691 (rank : 1071)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	332
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CBL_HUMAN
θ value	0.813845 (rank : 1257)	NC score	0.011486 (rank : 1588)
Query Neighborhood Hits	1804	Target Neighborhood Hits	353	Shared Neighborhood Hits	98
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CSF1_MOUSE
θ value	0.813845 (rank : 1258)	NC score	0.017607 (rank : 1492)
Query Neighborhood Hits	1804	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	P07141, Q8R3C8	Gene names	Csf1, Csfm
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF).

DTX2_MOUSE
θ value	0.813845 (rank : 1259)	NC score	0.005009 (rank : 1676)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R3P2, Q9CZV3, Q9ER07, Q9ER08	Gene names	Dtx2
Domain Architecture
Description	Protein deltex-2 (Deltex-2) (Deltex2) (mDTX2).

EMAL4_HUMAN
θ value	0.813845 (rank : 1260)	NC score	-0.003003 (rank : 1799)
Query Neighborhood Hits	1804	Target Neighborhood Hits	306	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

G3BP2_MOUSE
θ value	0.813845 (rank : 1261)	NC score	0.003423 (rank : 1700)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

GLI2_HUMAN
θ value	0.813845 (rank : 1262)	NC score	-0.018534 (rank : 1871)
Query Neighborhood Hits	1804	Target Neighborhood Hits	971	Shared Neighborhood Hits	153
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

HD_HUMAN
θ value	0.813845 (rank : 1263)	NC score	0.009193 (rank : 1622)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

K0528_MOUSE
θ value	0.813845 (rank : 1264)	NC score	0.020577 (rank : 1448)
Query Neighborhood Hits	1804	Target Neighborhood Hits	102	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

K1949_MOUSE
θ value	0.813845 (rank : 1265)	NC score	0.015434 (rank : 1529)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

PCDAB_HUMAN
θ value	0.813845 (rank : 1266)	NC score	-0.008035 (rank : 1836)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y5I1, O75279	Gene names	PCDHA11
Domain Architecture
Description	Protocadherin alpha 11 precursor (PCDH-alpha11).

PCQAP_MOUSE
θ value	0.813845 (rank : 1267)	NC score	0.053940 (rank : 1088)
Query Neighborhood Hits	1804	Target Neighborhood Hits	506	Shared Neighborhood Hits	158
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PERQ1_MOUSE
θ value	0.813845 (rank : 1268)	NC score	0.029149 (rank : 1320)
Query Neighborhood Hits	1804	Target Neighborhood Hits	215	Shared Neighborhood Hits	54
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

SIA7A_HUMAN
θ value	0.813845 (rank : 1269)	NC score	0.018543 (rank : 1481)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

SIX5_HUMAN
θ value	0.813845 (rank : 1270)	NC score	0.001693 (rank : 1732)
Query Neighborhood Hits	1804	Target Neighborhood Hits	386	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

SMG5_HUMAN
θ value	0.813845 (rank : 1271)	NC score	0.013459 (rank : 1561)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPR3, Q5QJE7, Q8IXC0, Q8IY09, Q96IJ7	Gene names	SMG5, EST1B, KIAA1089
Domain Architecture	No domain graphic available
Description	Protein SMG5 (SMG-5 homolog) (EST1-like protein B) (LPTS-interacting protein) (LPTS-RP1).

SRBS1_MOUSE
θ value	0.813845 (rank : 1272)	NC score	0.025504 (rank : 1376)
Query Neighborhood Hits	1804	Target Neighborhood Hits	409	Shared Neighborhood Hits	137
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

TNR3_MOUSE
θ value	0.813845 (rank : 1273)	NC score	-0.001777 (rank : 1784)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	8
SwissProt Accessions	P50284	Gene names	Ltbr, Tnfcr, Tnfrsf3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor).

UBP42_HUMAN
θ value	0.813845 (rank : 1274)	NC score	0.015615 (rank : 1525)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

VGLL4_MOUSE
θ value	0.813845 (rank : 1275)	NC score	0.011188 (rank : 1591)
Query Neighborhood Hits	1804	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q80V24	Gene names	Vgll4
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

WASL_HUMAN
θ value	0.813845 (rank : 1276)	NC score	0.048903 (rank : 1150)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASP_HUMAN
θ value	0.813845 (rank : 1277)	NC score	0.032794 (rank : 1281)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

ZN703_HUMAN
θ value	0.813845 (rank : 1278)	NC score	0.016396 (rank : 1516)
Query Neighborhood Hits	1804	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

ZO1_HUMAN
θ value	0.813845 (rank : 1279)	NC score	0.050275 (rank : 1132)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	226
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ANTR1_MOUSE
θ value	1.06291 (rank : 1280)	NC score	0.011075 (rank : 1592)
Query Neighborhood Hits	1804	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

BAI1_MOUSE
θ value	1.06291 (rank : 1281)	NC score	-0.003329 (rank : 1803)
Query Neighborhood Hits	1804	Target Neighborhood Hits	340	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BCL9_HUMAN
θ value	1.06291 (rank : 1282)	NC score	0.070740 (rank : 959)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1008	Shared Neighborhood Hits	390
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCLF1_HUMAN
θ value	1.06291 (rank : 1283)	NC score	0.029041 (rank : 1322)
Query Neighborhood Hits	1804	Target Neighborhood Hits	298	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

BUB1_MOUSE
θ value	1.06291 (rank : 1284)	NC score	0.603985 (rank : 794)
Query Neighborhood Hits	1804	Target Neighborhood Hits	583	Shared Neighborhood Hits	539
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CBX6_HUMAN
θ value	1.06291 (rank : 1285)	NC score	0.009074 (rank : 1623)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	40
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

CHD9_MOUSE
θ value	1.06291 (rank : 1286)	NC score	0.006072 (rank : 1661)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CKAP4_HUMAN
θ value	1.06291 (rank : 1287)	NC score	0.016588 (rank : 1505)
Query Neighborhood Hits	1804	Target Neighborhood Hits	592	Shared Neighborhood Hits	61
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CND1_HUMAN
θ value	1.06291 (rank : 1288)	NC score	0.005310 (rank : 1671)
Query Neighborhood Hits	1804	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

COBA2_HUMAN
θ value	1.06291 (rank : 1289)	NC score	0.014942 (rank : 1533)
Query Neighborhood Hits	1804	Target Neighborhood Hits	408	Shared Neighborhood Hits	125
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

COBA2_MOUSE
θ value	1.06291 (rank : 1290)	NC score	0.015560 (rank : 1526)
Query Neighborhood Hits	1804	Target Neighborhood Hits	501	Shared Neighborhood Hits	151
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CTND2_MOUSE
θ value	1.06291 (rank : 1291)	NC score	0.013893 (rank : 1552)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

DAB2P_HUMAN
θ value	1.06291 (rank : 1292)	NC score	0.015478 (rank : 1528)
Query Neighborhood Hits	1804	Target Neighborhood Hits	303	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

DAXX_HUMAN
θ value	1.06291 (rank : 1293)	NC score	0.014711 (rank : 1537)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

DNM3A_HUMAN
θ value	1.06291 (rank : 1294)	NC score	0.005853 (rank : 1664)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

ICAL_HUMAN
θ value	1.06291 (rank : 1295)	NC score	0.024511 (rank : 1393)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	102
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

LIPS_HUMAN
θ value	1.06291 (rank : 1296)	NC score	0.035144 (rank : 1257)
Query Neighborhood Hits	1804	Target Neighborhood Hits	314	Shared Neighborhood Hits	165
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

LSD1_MOUSE
θ value	1.06291 (rank : 1297)	NC score	0.013659 (rank : 1558)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZQ88, Q6PB53, Q8VEA1	Gene names	Aof2, Kiaa0601, Lsd1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

MKRN3_HUMAN
θ value	1.06291 (rank : 1298)	NC score	0.001762 (rank : 1729)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

PDLI7_MOUSE
θ value	1.06291 (rank : 1299)	NC score	0.030240 (rank : 1302)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	108
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PKHA4_HUMAN
θ value	1.06291 (rank : 1300)	NC score	0.017654 (rank : 1490)
Query Neighborhood Hits	1804	Target Neighborhood Hits	283	Shared Neighborhood Hits	101
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

RAI1_HUMAN
θ value	1.06291 (rank : 1301)	NC score	0.030856 (rank : 1297)
Query Neighborhood Hits	1804	Target Neighborhood Hits	360	Shared Neighborhood Hits	164
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RFIP1_HUMAN
θ value	1.06291 (rank : 1302)	NC score	0.026179 (rank : 1370)
Query Neighborhood Hits	1804	Target Neighborhood Hits	236	Shared Neighborhood Hits	94
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RIMS1_HUMAN
θ value	1.06291 (rank : 1303)	NC score	0.050509 (rank : 1127)
Query Neighborhood Hits	1804	Target Neighborhood Hits	437	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

SET1A_HUMAN
θ value	1.06291 (rank : 1304)	NC score	0.052142 (rank : 1106)
Query Neighborhood Hits	1804	Target Neighborhood Hits	690	Shared Neighborhood Hits	248
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SMAD4_HUMAN
θ value	1.06291 (rank : 1305)	NC score	0.001939 (rank : 1727)
Query Neighborhood Hits	1804	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SON_HUMAN
θ value	1.06291 (rank : 1306)	NC score	0.087119 (rank : 912)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1568	Shared Neighborhood Hits	516
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SYNP2_MOUSE
θ value	1.06291 (rank : 1307)	NC score	0.048894 (rank : 1152)
Query Neighborhood Hits	1804	Target Neighborhood Hits	252	Shared Neighborhood Hits	150
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

T22D2_HUMAN
θ value	1.06291 (rank : 1308)	NC score	0.034225 (rank : 1265)
Query Neighborhood Hits	1804	Target Neighborhood Hits	250	Shared Neighborhood Hits	109
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TF65_HUMAN
θ value	1.06291 (rank : 1309)	NC score	0.006388 (rank : 1656)
Query Neighborhood Hits	1804	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

TLE2_HUMAN
θ value	1.06291 (rank : 1310)	NC score	-0.007158 (rank : 1831)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	35
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

TOX_HUMAN
θ value	1.06291 (rank : 1311)	NC score	0.003755 (rank : 1692)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	31
SwissProt Accessions	O94900, Q96AV5	Gene names	TOX, KIAA0808
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TP53B_HUMAN
θ value	1.06291 (rank : 1312)	NC score	0.029912 (rank : 1305)
Query Neighborhood Hits	1804	Target Neighborhood Hits	413	Shared Neighborhood Hits	144
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TX1B3_HUMAN
θ value	1.06291 (rank : 1313)	NC score	0.066983 (rank : 987)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	110
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	1.06291 (rank : 1314)	NC score	0.066657 (rank : 989)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	109
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

WASF1_HUMAN
θ value	1.06291 (rank : 1315)	NC score	0.026854 (rank : 1357)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	101
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASF1_MOUSE
θ value	1.06291 (rank : 1316)	NC score	0.027307 (rank : 1346)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

WBS14_MOUSE
θ value	1.06291 (rank : 1317)	NC score	0.016423 (rank : 1513)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	66
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

3BP2_HUMAN
θ value	1.38821 (rank : 1318)	NC score	0.027918 (rank : 1337)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	116
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

APC_MOUSE
θ value	1.38821 (rank : 1319)	NC score	0.027243 (rank : 1347)
Query Neighborhood Hits	1804	Target Neighborhood Hits	441	Shared Neighborhood Hits	118
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

ATOH1_HUMAN
θ value	1.38821 (rank : 1320)	NC score	-0.002086 (rank : 1786)
Query Neighborhood Hits	1804	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

AXN1_MOUSE
θ value	1.38821 (rank : 1321)	NC score	0.005324 (rank : 1670)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

BAZ2A_HUMAN
θ value	1.38821 (rank : 1322)	NC score	0.034397 (rank : 1263)
Query Neighborhood Hits	1804	Target Neighborhood Hits	780	Shared Neighborhood Hits	264
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CAC1B_HUMAN
θ value	1.38821 (rank : 1323)	NC score	0.002026 (rank : 1724)
Query Neighborhood Hits	1804	Target Neighborhood Hits	257	Shared Neighborhood Hits	68
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CIC_HUMAN
θ value	1.38821 (rank : 1324)	NC score	0.056372 (rank : 1074)
Query Neighborhood Hits	1804	Target Neighborhood Hits	992	Shared Neighborhood Hits	382
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CITE4_HUMAN
θ value	1.38821 (rank : 1325)	NC score	0.019968 (rank : 1456)
Query Neighborhood Hits	1804	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q96RK1	Gene names	CITED4, MRG2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

CTND2_HUMAN
θ value	1.38821 (rank : 1326)	NC score	0.024246 (rank : 1396)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CYTSA_MOUSE
θ value	1.38821 (rank : 1327)	NC score	0.023108 (rank : 1414)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1104	Shared Neighborhood Hits	149
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

ELOA1_HUMAN
θ value	1.38821 (rank : 1328)	NC score	0.035394 (rank : 1254)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	131
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

GASP2_MOUSE
θ value	1.38821 (rank : 1329)	NC score	0.017900 (rank : 1487)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

HGS_MOUSE
θ value	1.38821 (rank : 1330)	NC score	0.025410 (rank : 1377)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	175
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IASPP_MOUSE
θ value	1.38821 (rank : 1331)	NC score	0.061788 (rank : 1023)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1024	Shared Neighborhood Hits	354
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IF4B_MOUSE
θ value	1.38821 (rank : 1332)	NC score	0.028494 (rank : 1325)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

JHD3B_MOUSE
θ value	1.38821 (rank : 1333)	NC score	0.006089 (rank : 1660)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

JPH4_HUMAN
θ value	1.38821 (rank : 1334)	NC score	0.007416 (rank : 1638)
Query Neighborhood Hits	1804	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

LIN7B_MOUSE
θ value	1.38821 (rank : 1335)	NC score	0.052529 (rank : 1102)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	124
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

MADCA_HUMAN
θ value	1.38821 (rank : 1336)	NC score	0.032696 (rank : 1282)
Query Neighborhood Hits	1804	Target Neighborhood Hits	221	Shared Neighborhood Hits	105
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MUCDL_MOUSE
θ value	1.38821 (rank : 1337)	NC score	0.024606 (rank : 1391)
Query Neighborhood Hits	1804	Target Neighborhood Hits	461	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NCOA5_MOUSE
θ value	1.38821 (rank : 1338)	NC score	0.016249 (rank : 1518)
Query Neighborhood Hits	1804	Target Neighborhood Hits	87	Shared Neighborhood Hits	40
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

OPHN1_HUMAN
θ value	1.38821 (rank : 1339)	NC score	0.002172 (rank : 1722)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

PAIP1_HUMAN
θ value	1.38821 (rank : 1340)	NC score	0.012986 (rank : 1567)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

PDLI2_MOUSE
θ value	1.38821 (rank : 1341)	NC score	0.053919 (rank : 1089)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	107
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

PER1_MOUSE
θ value	1.38821 (rank : 1342)	NC score	0.011670 (rank : 1584)
Query Neighborhood Hits	1804	Target Neighborhood Hits	235	Shared Neighborhood Hits	95
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PTN23_MOUSE
θ value	1.38821 (rank : 1343)	NC score	0.019504 (rank : 1463)
Query Neighborhood Hits	1804	Target Neighborhood Hits	726	Shared Neighborhood Hits	221
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PZRN3_HUMAN
θ value	1.38821 (rank : 1344)	NC score	0.029575 (rank : 1311)
Query Neighborhood Hits	1804	Target Neighborhood Hits	461	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RIMB1_HUMAN
θ value	1.38821 (rank : 1345)	NC score	0.051704 (rank : 1109)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1479	Shared Neighborhood Hits	336
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUSC1_MOUSE
θ value	1.38821 (rank : 1346)	NC score	0.014815 (rank : 1536)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

SGIP1_HUMAN
θ value	1.38821 (rank : 1347)	NC score	0.028008 (rank : 1334)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SNTG2_MOUSE
θ value	1.38821 (rank : 1348)	NC score	0.042263 (rank : 1207)
Query Neighborhood Hits	1804	Target Neighborhood Hits	176	Shared Neighborhood Hits	120
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

SOX13_MOUSE
θ value	1.38821 (rank : 1349)	NC score	0.026413 (rank : 1364)
Query Neighborhood Hits	1804	Target Neighborhood Hits	495	Shared Neighborhood Hits	195
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SRGP1_HUMAN
θ value	1.38821 (rank : 1350)	NC score	0.012462 (rank : 1575)
Query Neighborhood Hits	1804	Target Neighborhood Hits	390	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TB182_HUMAN
θ value	1.38821 (rank : 1351)	NC score	0.036079 (rank : 1249)
Query Neighborhood Hits	1804	Target Neighborhood Hits	414	Shared Neighborhood Hits	165
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TROAP_HUMAN
θ value	1.38821 (rank : 1352)	NC score	0.035796 (rank : 1251)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	123
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

VRK1_HUMAN
θ value	1.38821 (rank : 1353)	NC score	0.479015 (rank : 821)
Query Neighborhood Hits	1804	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

ZMYM3_MOUSE
θ value	1.38821 (rank : 1354)	NC score	0.008021 (rank : 1630)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

AFF2_HUMAN
θ value	1.81305 (rank : 1355)	NC score	0.036965 (rank : 1244)
Query Neighborhood Hits	1804	Target Neighborhood Hits	218	Shared Neighborhood Hits	102
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

APBB2_MOUSE
θ value	1.81305 (rank : 1356)	NC score	0.005172 (rank : 1673)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

ATX2_MOUSE
θ value	1.81305 (rank : 1357)	NC score	0.039154 (rank : 1226)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	189
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

BCAR3_MOUSE
θ value	1.81305 (rank : 1358)	NC score	0.018799 (rank : 1475)
Query Neighborhood Hits	1804	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

CBLB_MOUSE
θ value	1.81305 (rank : 1359)	NC score	0.003162 (rank : 1707)
Query Neighborhood Hits	1804	Target Neighborhood Hits	277	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CELR3_HUMAN
θ value	1.81305 (rank : 1360)	NC score	-0.012662 (rank : 1858)
Query Neighborhood Hits	1804	Target Neighborhood Hits	680	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

CIKS_HUMAN
θ value	1.81305 (rank : 1361)	NC score	0.011069 (rank : 1593)
Query Neighborhood Hits	1804	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CK5P2_MOUSE
θ value	1.81305 (rank : 1362)	NC score	0.029501 (rank : 1314)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1151	Shared Neighborhood Hits	153
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CLMN_MOUSE
θ value	1.81305 (rank : 1363)	NC score	0.004646 (rank : 1682)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

CO6A3_HUMAN
θ value	1.81305 (rank : 1364)	NC score	0.005499 (rank : 1668)
Query Neighborhood Hits	1804	Target Neighborhood Hits	317	Shared Neighborhood Hits	89
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

COAA1_HUMAN
θ value	1.81305 (rank : 1365)	NC score	0.013653 (rank : 1559)
Query Neighborhood Hits	1804	Target Neighborhood Hits	316	Shared Neighborhood Hits	109
SwissProt Accessions	Q03692	Gene names	COL10A1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

DOT1L_HUMAN
θ value	1.81305 (rank : 1366)	NC score	0.061284 (rank : 1029)
Query Neighborhood Hits	1804	Target Neighborhood Hits	660	Shared Neighborhood Hits	230
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

FMN2_MOUSE
θ value	1.81305 (rank : 1367)	NC score	0.018948 (rank : 1472)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	126
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

FOXL1_MOUSE
θ value	1.81305 (rank : 1368)	NC score	-0.003662 (rank : 1805)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

GUC2C_HUMAN
θ value	1.81305 (rank : 1369)	NC score	0.468258 (rank : 824)
Query Neighborhood Hits	1804	Target Neighborhood Hits	624	Shared Neighborhood Hits	584
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

HRX_HUMAN
θ value	1.81305 (rank : 1370)	NC score	0.032900 (rank : 1277)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	269
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

INVS_MOUSE
θ value	1.81305 (rank : 1371)	NC score	0.031546 (rank : 1290)
Query Neighborhood Hits	1804	Target Neighborhood Hits	609	Shared Neighborhood Hits	200
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ITCH_HUMAN
θ value	1.81305 (rank : 1372)	NC score	0.003440 (rank : 1699)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

K0562_MOUSE
θ value	1.81305 (rank : 1373)	NC score	0.009563 (rank : 1615)
Query Neighborhood Hits	1804	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

LIN7C_HUMAN
θ value	1.81305 (rank : 1374)	NC score	0.053194 (rank : 1096)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
θ value	1.81305 (rank : 1375)	NC score	0.053194 (rank : 1097)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LSD1_HUMAN
θ value	1.81305 (rank : 1376)	NC score	0.025902 (rank : 1372)
Query Neighborhood Hits	1804	Target Neighborhood Hits	455	Shared Neighborhood Hits	139
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

NCKX1_HUMAN
θ value	1.81305 (rank : 1377)	NC score	0.008021 (rank : 1631)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	61
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

NELF_HUMAN
θ value	1.81305 (rank : 1378)	NC score	0.006125 (rank : 1659)
Query Neighborhood Hits	1804	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

NEST_HUMAN
θ value	1.81305 (rank : 1379)	NC score	0.041332 (rank : 1212)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1305	Shared Neighborhood Hits	257
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NKTR_MOUSE
θ value	1.81305 (rank : 1380)	NC score	0.011693 (rank : 1583)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	116
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

NOTC2_HUMAN
θ value	1.81305 (rank : 1381)	NC score	0.002082 (rank : 1723)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1113	Shared Neighborhood Hits	199
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NR1H2_HUMAN
θ value	1.81305 (rank : 1382)	NC score	-0.008510 (rank : 1839)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PARD3_MOUSE
θ value	1.81305 (rank : 1383)	NC score	0.051545 (rank : 1114)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	135
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PDLI7_HUMAN
θ value	1.81305 (rank : 1384)	NC score	0.045865 (rank : 1175)
Query Neighborhood Hits	1804	Target Neighborhood Hits	547	Shared Neighborhood Hits	246
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PI5PA_HUMAN
θ value	1.81305 (rank : 1385)	NC score	0.060627 (rank : 1039)
Query Neighborhood Hits	1804	Target Neighborhood Hits	749	Shared Neighborhood Hits	325
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PICK1_HUMAN
θ value	1.81305 (rank : 1386)	NC score	0.031414 (rank : 1292)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PICK1_MOUSE
θ value	1.81305 (rank : 1387)	NC score	0.031649 (rank : 1289)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	82
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

PML_MOUSE
θ value	1.81305 (rank : 1388)	NC score	0.001647 (rank : 1735)
Query Neighborhood Hits	1804	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

PRCC_HUMAN
θ value	1.81305 (rank : 1389)	NC score	0.016411 (rank : 1514)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

RFIP4_MOUSE
θ value	1.81305 (rank : 1390)	NC score	0.022285 (rank : 1425)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RGS12_HUMAN
θ value	1.81305 (rank : 1391)	NC score	0.032343 (rank : 1286)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	167
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

RL1D1_HUMAN
θ value	1.81305 (rank : 1392)	NC score	0.036201 (rank : 1248)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	O76021, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9	Gene names	RSL1D1, CATX11, CSIG, PBK1
Domain Architecture	No domain graphic available
Description	Ribosomal L1 domain-containing protein 1 (Cellular senescence- inhibited gene protein) (Protein PBK1) (CATX-11).

SASH1_MOUSE
θ value	1.81305 (rank : 1393)	NC score	0.036676 (rank : 1246)
Query Neighborhood Hits	1804	Target Neighborhood Hits	263	Shared Neighborhood Hits	112
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SFPQ_MOUSE
θ value	1.81305 (rank : 1394)	NC score	0.047014 (rank : 1165)
Query Neighborhood Hits	1804	Target Neighborhood Hits	958	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SOX6_MOUSE
θ value	1.81305 (rank : 1395)	NC score	0.014655 (rank : 1539)
Query Neighborhood Hits	1804	Target Neighborhood Hits	341	Shared Neighborhood Hits	93
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

SPAST_MOUSE
θ value	1.81305 (rank : 1396)	NC score	-0.002236 (rank : 1790)
Query Neighborhood Hits	1804	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

SYBU_MOUSE
θ value	1.81305 (rank : 1397)	NC score	0.017544 (rank : 1494)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BHS8, Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BI27	Gene names	Sybu, Golsyn, Kiaa1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein) (m-Golsyn).

TBX2_HUMAN
θ value	1.81305 (rank : 1398)	NC score	0.004714 (rank : 1680)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	81
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

TCP10_HUMAN
θ value	1.81305 (rank : 1399)	NC score	0.025123 (rank : 1383)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q12799	Gene names	TCP10, TCP10A
Domain Architecture
Description	T-complex protein 10A homolog.

UBP21_MOUSE
θ value	1.81305 (rank : 1400)	NC score	-0.002184 (rank : 1788)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

UBP31_HUMAN
θ value	1.81305 (rank : 1401)	NC score	0.015005 (rank : 1531)
Query Neighborhood Hits	1804	Target Neighborhood Hits	293	Shared Neighborhood Hits	113
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

WASF2_HUMAN
θ value	1.81305 (rank : 1402)	NC score	0.027465 (rank : 1344)
Query Neighborhood Hits	1804	Target Neighborhood Hits	280	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASF3_HUMAN
θ value	1.81305 (rank : 1403)	NC score	0.029220 (rank : 1318)
Query Neighborhood Hits	1804	Target Neighborhood Hits	204	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

XYLT2_MOUSE
θ value	1.81305 (rank : 1404)	NC score	0.003250 (rank : 1703)
Query Neighborhood Hits	1804	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9EPL0, Q5SUY1, Q8K060	Gene names	Xylt2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (Peptide O- xylosyltransferase 2).

ZBTB4_HUMAN
θ value	1.81305 (rank : 1405)	NC score	-0.021751 (rank : 1874)
Query Neighborhood Hits	1804	Target Neighborhood Hits	926	Shared Neighborhood Hits	102
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

ABI2_HUMAN
θ value	2.36792 (rank : 1406)	NC score	0.028966 (rank : 1324)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

AP3B2_MOUSE
θ value	2.36792 (rank : 1407)	NC score	0.003209 (rank : 1704)
Query Neighborhood Hits	1804	Target Neighborhood Hits	246	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

ATBF1_MOUSE
θ value	2.36792 (rank : 1408)	NC score	-0.004450 (rank : 1812)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1841	Shared Neighborhood Hits	295
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CAC1B_MOUSE
θ value	2.36792 (rank : 1409)	NC score	0.005199 (rank : 1672)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	113
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CD248_MOUSE
θ value	2.36792 (rank : 1410)	NC score	0.013879 (rank : 1553)
Query Neighborhood Hits	1804	Target Neighborhood Hits	578	Shared Neighborhood Hits	176
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CF155_HUMAN
θ value	2.36792 (rank : 1411)	NC score	0.018631 (rank : 1478)
Query Neighborhood Hits	1804	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

CJ078_MOUSE
θ value	2.36792 (rank : 1412)	NC score	0.045552 (rank : 1178)
Query Neighborhood Hits	1804	Target Neighborhood Hits	559	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

CLCN1_MOUSE
θ value	2.36792 (rank : 1413)	NC score	0.000153 (rank : 1752)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CO2A1_HUMAN
θ value	2.36792 (rank : 1414)	NC score	0.016525 (rank : 1510)
Query Neighborhood Hits	1804	Target Neighborhood Hits	486	Shared Neighborhood Hits	149
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

CO4A1_MOUSE
θ value	2.36792 (rank : 1415)	NC score	0.015619 (rank : 1524)
Query Neighborhood Hits	1804	Target Neighborhood Hits	450	Shared Neighborhood Hits	142
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO5A1_HUMAN
θ value	2.36792 (rank : 1416)	NC score	0.017205 (rank : 1500)
Query Neighborhood Hits	1804	Target Neighborhood Hits	434	Shared Neighborhood Hits	151
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

CO5A1_MOUSE
θ value	2.36792 (rank : 1417)	NC score	0.016568 (rank : 1507)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	140
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO5A2_HUMAN
θ value	2.36792 (rank : 1418)	NC score	0.021208 (rank : 1436)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	218
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CPSF6_HUMAN
θ value	2.36792 (rank : 1419)	NC score	0.026334 (rank : 1366)
Query Neighborhood Hits	1804	Target Neighborhood Hits	359	Shared Neighborhood Hits	127
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	2.36792 (rank : 1420)	NC score	0.026949 (rank : 1355)
Query Neighborhood Hits	1804	Target Neighborhood Hits	356	Shared Neighborhood Hits	130
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CU005_HUMAN
θ value	2.36792 (rank : 1421)	NC score	0.006055 (rank : 1662)
Query Neighborhood Hits	1804	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3R5, Q9UEZ3	Gene names	C21orf5, KIAA0933
Domain Architecture
Description	Protein C21orf5.

CUL4B_HUMAN
θ value	2.36792 (rank : 1422)	NC score	0.000768 (rank : 1745)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

DGKZ_MOUSE
θ value	2.36792 (rank : 1423)	NC score	-0.000499 (rank : 1764)
Query Neighborhood Hits	1804	Target Neighborhood Hits	542	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

FA47B_HUMAN
θ value	2.36792 (rank : 1424)	NC score	0.054405 (rank : 1084)
Query Neighborhood Hits	1804	Target Neighborhood Hits	431	Shared Neighborhood Hits	209
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FGD1_MOUSE
θ value	2.36792 (rank : 1425)	NC score	0.012984 (rank : 1568)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	119
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

HUWE1_MOUSE
θ value	2.36792 (rank : 1426)	NC score	0.007460 (rank : 1636)
Query Neighborhood Hits	1804	Target Neighborhood Hits	406	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

INVO_MOUSE
θ value	2.36792 (rank : 1427)	NC score	0.056414 (rank : 1073)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	125
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

K1849_MOUSE
θ value	2.36792 (rank : 1428)	NC score	0.044757 (rank : 1188)
Query Neighborhood Hits	1804	Target Neighborhood Hits	335	Shared Neighborhood Hits	174
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KCNH2_HUMAN
θ value	2.36792 (rank : 1429)	NC score	0.004967 (rank : 1677)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KLF13_MOUSE
θ value	2.36792 (rank : 1430)	NC score	-0.025091 (rank : 1880)
Query Neighborhood Hits	1804	Target Neighborhood Hits	757	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

KTN1_MOUSE
θ value	2.36792 (rank : 1431)	NC score	0.029158 (rank : 1319)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1324	Shared Neighborhood Hits	167
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MCPH1_MOUSE
θ value	2.36792 (rank : 1432)	NC score	0.009750 (rank : 1613)
Query Neighborhood Hits	1804	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

MKL2_MOUSE
θ value	2.36792 (rank : 1433)	NC score	0.011597 (rank : 1586)
Query Neighborhood Hits	1804	Target Neighborhood Hits	269	Shared Neighborhood Hits	77
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

MYST4_HUMAN
θ value	2.36792 (rank : 1434)	NC score	0.013671 (rank : 1557)
Query Neighborhood Hits	1804	Target Neighborhood Hits	671	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NCOA2_HUMAN
θ value	2.36792 (rank : 1435)	NC score	0.009962 (rank : 1610)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	109
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

OPHN1_MOUSE
θ value	2.36792 (rank : 1436)	NC score	-0.000200 (rank : 1758)
Query Neighborhood Hits	1804	Target Neighborhood Hits	174	Shared Neighborhood Hits	32
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

PYGO2_HUMAN
θ value	2.36792 (rank : 1437)	NC score	0.018404 (rank : 1483)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

SIN3A_HUMAN
θ value	2.36792 (rank : 1438)	NC score	0.009857 (rank : 1612)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SNTA1_HUMAN
θ value	2.36792 (rank : 1439)	NC score	0.042942 (rank : 1198)
Query Neighborhood Hits	1804	Target Neighborhood Hits	186	Shared Neighborhood Hits	128
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SSH2_HUMAN
θ value	2.36792 (rank : 1440)	NC score	0.002969 (rank : 1711)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	33
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

TAI12_HUMAN
θ value	2.36792 (rank : 1441)	NC score	0.001221 (rank : 1741)
Query Neighborhood Hits	1804	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

TBX21_MOUSE
θ value	2.36792 (rank : 1442)	NC score	-0.000258 (rank : 1760)
Query Neighborhood Hits	1804	Target Neighborhood Hits	116	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

TMPSD_HUMAN
θ value	2.36792 (rank : 1443)	NC score	-0.007834 (rank : 1834)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TR150_HUMAN
θ value	2.36792 (rank : 1444)	NC score	0.019235 (rank : 1465)
Query Neighborhood Hits	1804	Target Neighborhood Hits	313	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

TRPM7_MOUSE
θ value	2.36792 (rank : 1445)	NC score	-0.002522 (rank : 1797)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

VINEX_MOUSE
θ value	2.36792 (rank : 1446)	NC score	0.022432 (rank : 1422)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YTDC1_HUMAN
θ value	2.36792 (rank : 1447)	NC score	0.021476 (rank : 1432)
Query Neighborhood Hits	1804	Target Neighborhood Hits	458	Shared Neighborhood Hits	108
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

ZEP2_MOUSE
θ value	2.36792 (rank : 1448)	NC score	-0.013927 (rank : 1863)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	142
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZN687_HUMAN
θ value	2.36792 (rank : 1449)	NC score	-0.007301 (rank : 1832)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1244	Shared Neighborhood Hits	256
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

3BP1_HUMAN
θ value	3.0926 (rank : 1450)	NC score	0.020876 (rank : 1444)
Query Neighborhood Hits	1804	Target Neighborhood Hits	376	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

AGRIN_HUMAN
θ value	3.0926 (rank : 1451)	NC score	-0.006658 (rank : 1829)
Query Neighborhood Hits	1804	Target Neighborhood Hits	582	Shared Neighborhood Hits	79
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AMPH_HUMAN
θ value	3.0926 (rank : 1452)	NC score	0.040577 (rank : 1219)
Query Neighborhood Hits	1804	Target Neighborhood Hits	455	Shared Neighborhood Hits	169
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

APBA1_HUMAN
θ value	3.0926 (rank : 1453)	NC score	0.051228 (rank : 1119)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	166
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

ASXL1_HUMAN
θ value	3.0926 (rank : 1454)	NC score	0.025312 (rank : 1379)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	104
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

BAZ2A_MOUSE
θ value	3.0926 (rank : 1455)	NC score	0.038634 (rank : 1234)
Query Neighborhood Hits	1804	Target Neighborhood Hits	744	Shared Neighborhood Hits	261
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CAC1A_HUMAN
θ value	3.0926 (rank : 1456)	NC score	0.009471 (rank : 1618)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	145
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CCD96_HUMAN
θ value	3.0926 (rank : 1457)	NC score	0.032330 (rank : 1287)
Query Neighborhood Hits	1804	Target Neighborhood Hits	595	Shared Neighborhood Hits	119
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCNK_HUMAN
θ value	3.0926 (rank : 1458)	NC score	0.007217 (rank : 1641)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O75909, Q96B63, Q9NNY9	Gene names	CCNK, CPR4
Domain Architecture
Description	Cyclin-K.

CD2_HUMAN
θ value	3.0926 (rank : 1459)	NC score	0.051129 (rank : 1121)
Query Neighborhood Hits	1804	Target Neighborhood Hits	504	Shared Neighborhood Hits	219
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CDN1C_MOUSE
θ value	3.0926 (rank : 1460)	NC score	0.016310 (rank : 1517)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CK035_MOUSE
θ value	3.0926 (rank : 1461)	NC score	0.005368 (rank : 1669)
Query Neighborhood Hits	1804	Target Neighborhood Hits	91	Shared Neighborhood Hits	13
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

DCX_MOUSE
θ value	3.0926 (rank : 1462)	NC score	0.067424 (rank : 980)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	64
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DLG3_HUMAN
θ value	3.0926 (rank : 1463)	NC score	0.049663 (rank : 1139)
Query Neighborhood Hits	1804	Target Neighborhood Hits	269	Shared Neighborhood Hits	139
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

DLG3_MOUSE
θ value	3.0926 (rank : 1464)	NC score	0.050118 (rank : 1136)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	142
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

DOCK4_HUMAN
θ value	3.0926 (rank : 1465)	NC score	0.010071 (rank : 1608)
Query Neighborhood Hits	1804	Target Neighborhood Hits	237	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

HCN2_HUMAN
θ value	3.0926 (rank : 1466)	NC score	0.026623 (rank : 1362)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HXC12_MOUSE
θ value	3.0926 (rank : 1467)	NC score	-0.012610 (rank : 1857)
Query Neighborhood Hits	1804	Target Neighborhood Hits	316	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

JADE2_HUMAN
θ value	3.0926 (rank : 1468)	NC score	0.007158 (rank : 1644)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

KI67_HUMAN
θ value	3.0926 (rank : 1469)	NC score	0.060840 (rank : 1035)
Query Neighborhood Hits	1804	Target Neighborhood Hits	581	Shared Neighborhood Hits	201
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

LARP4_MOUSE
θ value	3.0926 (rank : 1470)	NC score	0.030232 (rank : 1303)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

LRTM3_HUMAN
θ value	3.0926 (rank : 1471)	NC score	-0.008225 (rank : 1837)
Query Neighborhood Hits	1804	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

MAGB6_HUMAN
θ value	3.0926 (rank : 1472)	NC score	0.005505 (rank : 1667)
Query Neighborhood Hits	1804	Target Neighborhood Hits	184	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

MATR3_HUMAN
θ value	3.0926 (rank : 1473)	NC score	0.006670 (rank : 1649)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	63
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

MORC2_HUMAN
θ value	3.0926 (rank : 1474)	NC score	0.011987 (rank : 1580)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

MUC2_HUMAN
θ value	3.0926 (rank : 1475)	NC score	0.035225 (rank : 1256)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	239
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MYO9B_HUMAN
θ value	3.0926 (rank : 1476)	NC score	0.048373 (rank : 1157)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	249
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NEUM_HUMAN
θ value	3.0926 (rank : 1477)	NC score	0.031319 (rank : 1295)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	62
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

NHS_HUMAN
θ value	3.0926 (rank : 1478)	NC score	0.024981 (rank : 1387)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	85
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

NKX61_MOUSE
θ value	3.0926 (rank : 1479)	NC score	-0.010124 (rank : 1849)
Query Neighborhood Hits	1804	Target Neighborhood Hits	439	Shared Neighborhood Hits	61
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

PCDA3_HUMAN
θ value	3.0926 (rank : 1480)	NC score	-0.007842 (rank : 1835)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

PHC2_MOUSE
θ value	3.0926 (rank : 1481)	NC score	0.017321 (rank : 1497)
Query Neighborhood Hits	1804	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

PROL4_HUMAN
θ value	3.0926 (rank : 1482)	NC score	0.010928 (rank : 1595)
Query Neighborhood Hits	1804	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q16378, Q8NFB3	Gene names	PRR4, LPRP, PROL4
Domain Architecture	No domain graphic available
Description	Proline-rich protein 4 precursor (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4).

PRR6_HUMAN
θ value	3.0926 (rank : 1483)	NC score	0.009596 (rank : 1614)
Query Neighborhood Hits	1804	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z7K6, Q3L8N5, Q8NFH6	Gene names	PRR6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6 (Nuclear protein p30).

PZRN3_MOUSE
θ value	3.0926 (rank : 1484)	NC score	0.029515 (rank : 1313)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	133
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RAI1_MOUSE
θ value	3.0926 (rank : 1485)	NC score	0.027499 (rank : 1343)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	141
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RC3H1_MOUSE
θ value	3.0926 (rank : 1486)	NC score	-0.000594 (rank : 1768)
Query Neighborhood Hits	1804	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

RIOK2_MOUSE
θ value	3.0926 (rank : 1487)	NC score	0.068415 (rank : 973)
Query Neighborhood Hits	1804	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

TBC10_HUMAN
θ value	3.0926 (rank : 1488)	NC score	0.000707 (rank : 1748)
Query Neighborhood Hits	1804	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXI6, O76053, Q543A2	Gene names	TBC1D10A, EPI64, TBC1D10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

TM108_HUMAN
θ value	3.0926 (rank : 1489)	NC score	0.035261 (rank : 1255)
Query Neighborhood Hits	1804	Target Neighborhood Hits	166	Shared Neighborhood Hits	91
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TNC6B_HUMAN
θ value	3.0926 (rank : 1490)	NC score	0.014517 (rank : 1544)
Query Neighborhood Hits	1804	Target Neighborhood Hits	256	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

TNR6A_HUMAN
θ value	3.0926 (rank : 1491)	NC score	0.018611 (rank : 1479)
Query Neighborhood Hits	1804	Target Neighborhood Hits	343	Shared Neighborhood Hits	109
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

TTLL7_HUMAN
θ value	3.0926 (rank : 1492)	NC score	0.003579 (rank : 1696)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

XYLT2_HUMAN
θ value	3.0926 (rank : 1493)	NC score	0.002980 (rank : 1709)
Query Neighborhood Hits	1804	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H1B5, Q6UY41, Q86V00	Gene names	XYLT2, XT2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (xylT-II) (XT-II) (Peptide O-xylosyltransferase 1).

ZFP91_MOUSE
θ value	3.0926 (rank : 1494)	NC score	-0.025310 (rank : 1882)
Query Neighborhood Hits	1804	Target Neighborhood Hits	742	Shared Neighborhood Hits	46
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

ZN598_HUMAN
θ value	3.0926 (rank : 1495)	NC score	0.017210 (rank : 1499)
Query Neighborhood Hits	1804	Target Neighborhood Hits	339	Shared Neighborhood Hits	86
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

AKTS1_MOUSE
θ value	4.03905 (rank : 1496)	NC score	0.006237 (rank : 1658)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D1F4	Gene names	Akt1s1, Pras
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate).

AUTS2_HUMAN
θ value	4.03905 (rank : 1497)	NC score	0.028038 (rank : 1333)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

B3A3_HUMAN
θ value	4.03905 (rank : 1498)	NC score	0.001339 (rank : 1739)
Query Neighborhood Hits	1804	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

BCL6_MOUSE
θ value	4.03905 (rank : 1499)	NC score	-0.024991 (rank : 1879)
Query Neighborhood Hits	1804	Target Neighborhood Hits	913	Shared Neighborhood Hits	96
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

BCOR_HUMAN
θ value	4.03905 (rank : 1500)	NC score	0.022537 (rank : 1420)
Query Neighborhood Hits	1804	Target Neighborhood Hits	609	Shared Neighborhood Hits	168
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CCG8_HUMAN
θ value	4.03905 (rank : 1501)	NC score	-0.001537 (rank : 1783)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXS5, Q9BXT0, Q9BY23	Gene names	CACNG8, CACNG6
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

CDC20_MOUSE
θ value	4.03905 (rank : 1502)	NC score	-0.009692 (rank : 1846)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

CDT1_MOUSE
θ value	4.03905 (rank : 1503)	NC score	0.013403 (rank : 1564)
Query Neighborhood Hits	1804	Target Neighborhood Hits	72	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CEP35_HUMAN
θ value	4.03905 (rank : 1504)	NC score	0.032555 (rank : 1284)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	159
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CGRE1_HUMAN
θ value	4.03905 (rank : 1505)	NC score	0.029877 (rank : 1307)
Query Neighborhood Hits	1804	Target Neighborhood Hits	354	Shared Neighborhood Hits	127
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CNGB3_HUMAN
θ value	4.03905 (rank : 1506)	NC score	0.019028 (rank : 1470)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CO039_MOUSE
θ value	4.03905 (rank : 1507)	NC score	0.057363 (rank : 1064)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	219
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CO4A1_HUMAN
θ value	4.03905 (rank : 1508)	NC score	0.012779 (rank : 1571)
Query Neighborhood Hits	1804	Target Neighborhood Hits	425	Shared Neighborhood Hits	128
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

COAA1_MOUSE
θ value	4.03905 (rank : 1509)	NC score	0.008804 (rank : 1625)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	87
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

CROCC_HUMAN
θ value	4.03905 (rank : 1510)	NC score	0.029689 (rank : 1310)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1409	Shared Neighborhood Hits	170
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DCBD1_HUMAN
θ value	4.03905 (rank : 1511)	NC score	0.002422 (rank : 1718)
Query Neighborhood Hits	1804	Target Neighborhood Hits	110	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

DSPP_HUMAN
θ value	4.03905 (rank : 1512)	NC score	0.027039 (rank : 1352)
Query Neighborhood Hits	1804	Target Neighborhood Hits	645	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

EST1A_HUMAN
θ value	4.03905 (rank : 1513)	NC score	0.009457 (rank : 1619)
Query Neighborhood Hits	1804	Target Neighborhood Hits	98	Shared Neighborhood Hits	20
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

EVL_HUMAN
θ value	4.03905 (rank : 1514)	NC score	0.025590 (rank : 1374)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

FA47A_HUMAN
θ value	4.03905 (rank : 1515)	NC score	0.062771 (rank : 1017)
Query Neighborhood Hits	1804	Target Neighborhood Hits	451	Shared Neighborhood Hits	215
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FOXC2_HUMAN
θ value	4.03905 (rank : 1516)	NC score	-0.000521 (rank : 1766)
Query Neighborhood Hits	1804	Target Neighborhood Hits	236	Shared Neighborhood Hits	82
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

FOXM1_HUMAN
θ value	4.03905 (rank : 1517)	NC score	0.002014 (rank : 1726)
Query Neighborhood Hits	1804	Target Neighborhood Hits	167	Shared Neighborhood Hits	53
SwissProt Accessions	Q08050, O43258, O43259, O43260, Q4ZGG7, Q9BRL2	Gene names	FOXM1, FKHL16, HFH11, MPP2, WIN
Domain Architecture
Description	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11) (HFH-11) (Winged helix factor from INS-1 cells) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident).

FYB_MOUSE
θ value	4.03905 (rank : 1518)	NC score	0.026395 (rank : 1365)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	66
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

G3BP2_HUMAN
θ value	4.03905 (rank : 1519)	NC score	0.002199 (rank : 1720)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

H15_MOUSE
θ value	4.03905 (rank : 1520)	NC score	0.014885 (rank : 1535)
Query Neighborhood Hits	1804	Target Neighborhood Hits	79	Shared Neighborhood Hits	42
SwissProt Accessions	P43276, Q9CRM8	Gene names	Hist1h1b, H1f5
Domain Architecture
Description	Histone H1.5 (H1 VAR.5) (H1b).

HAIR_HUMAN
θ value	4.03905 (rank : 1521)	NC score	0.008342 (rank : 1628)
Query Neighborhood Hits	1804	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

HNF3A_MOUSE
θ value	4.03905 (rank : 1522)	NC score	-0.003686 (rank : 1806)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	34
SwissProt Accessions	P35582, Q61108	Gene names	Foxa1, Hnf3a, Tcf-3a, Tcf3a
Domain Architecture
Description	Hepatocyte nuclear factor 3-alpha (HNF-3A) (Forkhead box protein A1).

JPH1_MOUSE
θ value	4.03905 (rank : 1523)	NC score	0.006410 (rank : 1654)
Query Neighborhood Hits	1804	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

JPH2_MOUSE
θ value	4.03905 (rank : 1524)	NC score	0.014344 (rank : 1547)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K1849_HUMAN
θ value	4.03905 (rank : 1525)	NC score	0.038662 (rank : 1233)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	120
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

KCNH3_HUMAN
θ value	4.03905 (rank : 1526)	NC score	0.007916 (rank : 1634)
Query Neighborhood Hits	1804	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
θ value	4.03905 (rank : 1527)	NC score	0.005123 (rank : 1674)
Query Neighborhood Hits	1804	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNK4_HUMAN
θ value	4.03905 (rank : 1528)	NC score	-0.000287 (rank : 1761)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCTD2_HUMAN
θ value	4.03905 (rank : 1529)	NC score	-0.000924 (rank : 1772)
Query Neighborhood Hits	1804	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	Q14681	Gene names	KCTD2, KIAA0176
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD2.

KI13A_MOUSE
θ value	4.03905 (rank : 1530)	NC score	0.000081 (rank : 1753)
Query Neighborhood Hits	1804	Target Neighborhood Hits	395	Shared Neighborhood Hits	63
SwissProt Accessions	Q9EQW7, O35062	Gene names	Kif13a
Domain Architecture
Description	Kinesin-like protein KIF13A.

LIN7A_HUMAN
θ value	4.03905 (rank : 1531)	NC score	0.054735 (rank : 1082)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

LIN7A_MOUSE
θ value	4.03905 (rank : 1532)	NC score	0.054816 (rank : 1081)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LZTS2_MOUSE
θ value	4.03905 (rank : 1533)	NC score	0.027117 (rank : 1351)
Query Neighborhood Hits	1804	Target Neighborhood Hits	423	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

MAGC1_HUMAN
θ value	4.03905 (rank : 1534)	NC score	0.012485 (rank : 1574)
Query Neighborhood Hits	1804	Target Neighborhood Hits	431	Shared Neighborhood Hits	172
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MIA2_MOUSE
θ value	4.03905 (rank : 1535)	NC score	0.004907 (rank : 1678)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

MKL2_HUMAN
θ value	4.03905 (rank : 1536)	NC score	0.016556 (rank : 1508)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

MY18B_HUMAN
θ value	4.03905 (rank : 1537)	NC score	0.040720 (rank : 1216)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1299	Shared Neighborhood Hits	262
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYPT1_MOUSE
θ value	4.03905 (rank : 1538)	NC score	0.015679 (rank : 1523)
Query Neighborhood Hits	1804	Target Neighborhood Hits	539	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

NCOR1_MOUSE
θ value	4.03905 (rank : 1539)	NC score	0.044411 (rank : 1189)
Query Neighborhood Hits	1804	Target Neighborhood Hits	521	Shared Neighborhood Hits	169
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NFRKB_HUMAN
θ value	4.03905 (rank : 1540)	NC score	0.023527 (rank : 1403)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	90
SwissProt Accessions	Q6P4R8, Q12869, Q15312, Q9H048	Gene names	NFRKB
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

NIBA_HUMAN
θ value	4.03905 (rank : 1541)	NC score	0.004373 (rank : 1684)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZQ8, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9	Gene names	C1orf24
Domain Architecture	No domain graphic available
Description	Niban protein.

NOP56_MOUSE
θ value	4.03905 (rank : 1542)	NC score	0.009303 (rank : 1620)
Query Neighborhood Hits	1804	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

NPAS3_HUMAN
θ value	4.03905 (rank : 1543)	NC score	-0.002488 (rank : 1796)
Query Neighborhood Hits	1804	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

OXR1_MOUSE
θ value	4.03905 (rank : 1544)	NC score	0.024091 (rank : 1398)
Query Neighborhood Hits	1804	Target Neighborhood Hits	516	Shared Neighborhood Hits	127
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

P66A_HUMAN
θ value	4.03905 (rank : 1545)	NC score	0.012269 (rank : 1578)
Query Neighborhood Hits	1804	Target Neighborhood Hits	111	Shared Neighborhood Hits	45
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

PARD3_HUMAN
θ value	4.03905 (rank : 1546)	NC score	0.051429 (rank : 1115)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PELP1_HUMAN
θ value	4.03905 (rank : 1547)	NC score	0.032425 (rank : 1285)
Query Neighborhood Hits	1804	Target Neighborhood Hits	596	Shared Neighborhood Hits	163
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PEX5R_HUMAN
θ value	4.03905 (rank : 1548)	NC score	-0.000252 (rank : 1759)
Query Neighborhood Hits	1804	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

PKHA6_HUMAN
θ value	4.03905 (rank : 1549)	NC score	0.034705 (rank : 1262)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PR285_HUMAN
θ value	4.03905 (rank : 1550)	NC score	0.002017 (rank : 1725)
Query Neighborhood Hits	1804	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

PSL1_HUMAN
θ value	4.03905 (rank : 1551)	NC score	0.049630 (rank : 1142)
Query Neighborhood Hits	1804	Target Neighborhood Hits	650	Shared Neighborhood Hits	293
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RBM22_HUMAN
θ value	4.03905 (rank : 1552)	NC score	0.000947 (rank : 1743)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
θ value	4.03905 (rank : 1553)	NC score	0.000947 (rank : 1744)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

REPS2_HUMAN
θ value	4.03905 (rank : 1554)	NC score	0.008929 (rank : 1624)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

RHG04_HUMAN
θ value	4.03905 (rank : 1555)	NC score	0.010224 (rank : 1606)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

SGIP1_MOUSE
θ value	4.03905 (rank : 1556)	NC score	0.024544 (rank : 1392)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SNTG1_HUMAN
θ value	4.03905 (rank : 1557)	NC score	0.042473 (rank : 1202)
Query Neighborhood Hits	1804	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG1_MOUSE
θ value	4.03905 (rank : 1558)	NC score	0.042293 (rank : 1206)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	122
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SYNP2_HUMAN
θ value	4.03905 (rank : 1559)	NC score	0.050290 (rank : 1131)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

SYP2L_HUMAN
θ value	4.03905 (rank : 1560)	NC score	0.060773 (rank : 1037)
Query Neighborhood Hits	1804	Target Neighborhood Hits	400	Shared Neighborhood Hits	237
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

SYTL1_HUMAN
θ value	4.03905 (rank : 1561)	NC score	0.022497 (rank : 1421)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

TCGAP_HUMAN
θ value	4.03905 (rank : 1562)	NC score	0.032807 (rank : 1280)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	305
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TMPSD_MOUSE
θ value	4.03905 (rank : 1563)	NC score	-0.007665 (rank : 1833)
Query Neighborhood Hits	1804	Target Neighborhood Hits	334	Shared Neighborhood Hits	81
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

UBAP1_MOUSE
θ value	4.03905 (rank : 1564)	NC score	0.002922 (rank : 1712)
Query Neighborhood Hits	1804	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BH48, Q8BQ80, Q8BSW6, Q9D749, Q9ERV5	Gene names	Ubap1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP) (Ubiquitin-associated protein NAG20).

WASF4_HUMAN
θ value	4.03905 (rank : 1565)	NC score	0.031868 (rank : 1288)
Query Neighborhood Hits	1804	Target Neighborhood Hits	282	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASP_MOUSE
θ value	4.03905 (rank : 1566)	NC score	0.032684 (rank : 1283)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	110
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

WFS1_HUMAN
θ value	4.03905 (rank : 1567)	NC score	0.005036 (rank : 1675)
Query Neighborhood Hits	1804	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

ZFHX2_HUMAN
θ value	4.03905 (rank : 1568)	NC score	-0.010718 (rank : 1853)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ZN541_HUMAN
θ value	4.03905 (rank : 1569)	NC score	0.019947 (rank : 1457)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

ABCA4_MOUSE
θ value	5.27518 (rank : 1570)	NC score	-0.006954 (rank : 1830)
Query Neighborhood Hits	1804	Target Neighborhood Hits	126	Shared Neighborhood Hits	9
SwissProt Accessions	O35600	Gene names	Abca4, Abcr
Domain Architecture
Description	Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP).

ACM4_MOUSE
θ value	5.27518 (rank : 1571)	NC score	-0.025845 (rank : 1885)
Query Neighborhood Hits	1804	Target Neighborhood Hits	894	Shared Neighborhood Hits	22
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).

ADAM9_HUMAN
θ value	5.27518 (rank : 1572)	NC score	-0.006011 (rank : 1821)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

ARI5B_HUMAN
θ value	5.27518 (rank : 1573)	NC score	0.021036 (rank : 1439)
Query Neighborhood Hits	1804	Target Neighborhood Hits	328	Shared Neighborhood Hits	109
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

ARX_HUMAN
θ value	5.27518 (rank : 1574)	NC score	-0.013317 (rank : 1862)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	40
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ARX_MOUSE
θ value	5.27518 (rank : 1575)	NC score	-0.013252 (rank : 1861)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	39
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ASXL1_MOUSE
θ value	5.27518 (rank : 1576)	NC score	0.014543 (rank : 1543)
Query Neighborhood Hits	1804	Target Neighborhood Hits	182	Shared Neighborhood Hits	70
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

ATX2L_HUMAN
θ value	5.27518 (rank : 1577)	NC score	0.045126 (rank : 1183)
Query Neighborhood Hits	1804	Target Neighborhood Hits	443	Shared Neighborhood Hits	191
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

BAI2_MOUSE
θ value	5.27518 (rank : 1578)	NC score	-0.005888 (rank : 1819)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAP1_HUMAN
θ value	5.27518 (rank : 1579)	NC score	0.013449 (rank : 1562)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q92560, Q6LEM0, Q7Z5E8	Gene names	BAP1, KIAA0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Cerebral protein 6).

BAP1_MOUSE
θ value	5.27518 (rank : 1580)	NC score	0.014687 (rank : 1538)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

CAC1S_HUMAN
θ value	5.27518 (rank : 1581)	NC score	-0.002352 (rank : 1792)
Query Neighborhood Hits	1804	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAH9_HUMAN
θ value	5.27518 (rank : 1582)	NC score	-0.003828 (rank : 1808)
Query Neighborhood Hits	1804	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	Q16790	Gene names	CA9, G250, MN
Domain Architecture
Description	Carbonic anhydrase 9 precursor (EC 4.2.1.1) (Carbonic anhydrase IX) (Carbonate dehydratase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC- associated antigen G250) (pMW1).

CK5P2_HUMAN
θ value	5.27518 (rank : 1583)	NC score	0.029916 (rank : 1304)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1433	Shared Neighborhood Hits	197
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CO4A2_MOUSE
θ value	5.27518 (rank : 1584)	NC score	0.013074 (rank : 1566)
Query Neighborhood Hits	1804	Target Neighborhood Hits	492	Shared Neighborhood Hits	148
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CO6A1_HUMAN
θ value	5.27518 (rank : 1585)	NC score	0.003192 (rank : 1706)
Query Neighborhood Hits	1804	Target Neighborhood Hits	264	Shared Neighborhood Hits	57
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

COBA1_HUMAN
θ value	5.27518 (rank : 1586)	NC score	0.014083 (rank : 1550)
Query Neighborhood Hits	1804	Target Neighborhood Hits	491	Shared Neighborhood Hits	140
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COHA1_MOUSE
θ value	5.27518 (rank : 1587)	NC score	0.023174 (rank : 1413)
Query Neighborhood Hits	1804	Target Neighborhood Hits	414	Shared Neighborhood Hits	149
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CSPG2_MOUSE
θ value	5.27518 (rank : 1588)	NC score	-0.004004 (rank : 1810)
Query Neighborhood Hits	1804	Target Neighborhood Hits	711	Shared Neighborhood Hits	103
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CUTL2_HUMAN
θ value	5.27518 (rank : 1589)	NC score	0.023296 (rank : 1408)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	200
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DCX_HUMAN
θ value	5.27518 (rank : 1590)	NC score	0.070504 (rank : 961)
Query Neighborhood Hits	1804	Target Neighborhood Hits	141	Shared Neighborhood Hits	76
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DDEF2_MOUSE
θ value	5.27518 (rank : 1591)	NC score	0.009875 (rank : 1611)
Query Neighborhood Hits	1804	Target Neighborhood Hits	625	Shared Neighborhood Hits	134
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DLX3_HUMAN
θ value	5.27518 (rank : 1592)	NC score	-0.012700 (rank : 1859)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	34
SwissProt Accessions	O60479	Gene names	DLX3
Domain Architecture
Description	Homeobox protein DLX-3.

ENAH_HUMAN
θ value	5.27518 (rank : 1593)	NC score	0.054326 (rank : 1085)
Query Neighborhood Hits	1804	Target Neighborhood Hits	784	Shared Neighborhood Hits	188
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ES8L1_HUMAN
θ value	5.27518 (rank : 1594)	NC score	0.021258 (rank : 1435)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FMN1B_MOUSE
θ value	5.27518 (rank : 1595)	NC score	0.020972 (rank : 1440)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	148
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

IASPP_HUMAN
θ value	5.27518 (rank : 1596)	NC score	0.040871 (rank : 1215)
Query Neighborhood Hits	1804	Target Neighborhood Hits	688	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IF39_HUMAN
θ value	5.27518 (rank : 1597)	NC score	0.011191 (rank : 1590)
Query Neighborhood Hits	1804	Target Neighborhood Hits	187	Shared Neighborhood Hits	53
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

IF4G1_HUMAN
θ value	5.27518 (rank : 1598)	NC score	0.020812 (rank : 1446)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	151
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

INT1_HUMAN
θ value	5.27518 (rank : 1599)	NC score	0.002725 (rank : 1716)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

IRX5_HUMAN
θ value	5.27518 (rank : 1600)	NC score	0.001936 (rank : 1728)
Query Neighborhood Hits	1804	Target Neighborhood Hits	362	Shared Neighborhood Hits	79
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

JHD1B_HUMAN
θ value	5.27518 (rank : 1601)	NC score	-0.000023 (rank : 1757)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NHM5, Q8NCI2, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75	Gene names	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (Protein JEMMA) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (CXXC-type zinc finger protein 2) (Protein-containing CXXC domain 2).

JHD3B_HUMAN
θ value	5.27518 (rank : 1602)	NC score	0.002753 (rank : 1715)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	40
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

JIP1_MOUSE
θ value	5.27518 (rank : 1603)	NC score	0.021419 (rank : 1433)
Query Neighborhood Hits	1804	Target Neighborhood Hits	259	Shared Neighborhood Hits	118
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

KIF1C_HUMAN
θ value	5.27518 (rank : 1604)	NC score	-0.006159 (rank : 1824)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	O43896, O75186	Gene names	KIF1C, KIAA0706
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

KLF16_HUMAN
θ value	5.27518 (rank : 1605)	NC score	-0.025482 (rank : 1884)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BXK1	Gene names	KLF16, BTEB4, NSLP2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor NSLP2).

KLF17_HUMAN
θ value	5.27518 (rank : 1606)	NC score	-0.020793 (rank : 1873)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	125
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

LR37A_HUMAN
θ value	5.27518 (rank : 1607)	NC score	0.034051 (rank : 1269)
Query Neighborhood Hits	1804	Target Neighborhood Hits	720	Shared Neighborhood Hits	225
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LTBP2_MOUSE
θ value	5.27518 (rank : 1608)	NC score	-0.005867 (rank : 1818)
Query Neighborhood Hits	1804	Target Neighborhood Hits	617	Shared Neighborhood Hits	105
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

LYAR_HUMAN
θ value	5.27518 (rank : 1609)	NC score	0.015551 (rank : 1527)
Query Neighborhood Hits	1804	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NX58, Q6FI78, Q9NYS1	Gene names	LYAR
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

MAML1_HUMAN
θ value	5.27518 (rank : 1610)	NC score	0.018864 (rank : 1473)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MBB1A_MOUSE
θ value	5.27518 (rank : 1611)	NC score	0.023258 (rank : 1410)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

MEGF9_MOUSE
θ value	5.27518 (rank : 1612)	NC score	0.025353 (rank : 1378)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	271
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MUC5B_HUMAN
θ value	5.27518 (rank : 1613)	NC score	0.026723 (rank : 1360)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	245
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

NCOA5_HUMAN
θ value	5.27518 (rank : 1614)	NC score	0.017724 (rank : 1488)
Query Neighborhood Hits	1804	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

NFAC1_HUMAN
θ value	5.27518 (rank : 1615)	NC score	0.016503 (rank : 1512)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	140
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NIPBL_HUMAN
θ value	5.27518 (rank : 1616)	NC score	0.068774 (rank : 970)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1311	Shared Neighborhood Hits	391
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NRG2_HUMAN
θ value	5.27518 (rank : 1617)	NC score	0.027147 (rank : 1350)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	87
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

ODO2_HUMAN
θ value	5.27518 (rank : 1618)	NC score	0.007407 (rank : 1639)
Query Neighborhood Hits	1804	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

PAIRB_MOUSE
θ value	5.27518 (rank : 1619)	NC score	0.003936 (rank : 1688)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CY58, Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6	Gene names	Serbp1, Pairbp1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

PARM1_MOUSE
θ value	5.27518 (rank : 1620)	NC score	0.026833 (rank : 1358)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	59
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

PCDA1_HUMAN
θ value	5.27518 (rank : 1621)	NC score	-0.008540 (rank : 1840)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5I3, O75288, Q9NRT7	Gene names	PCDHA1
Domain Architecture
Description	Protocadherin alpha 1 precursor (PCDH-alpha1).

PCDA5_HUMAN
θ value	5.27518 (rank : 1622)	NC score	-0.008340 (rank : 1838)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

PCDA6_HUMAN
θ value	5.27518 (rank : 1623)	NC score	-0.008954 (rank : 1843)
Query Neighborhood Hits	1804	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UN73, O75283, Q9NRT8	Gene names	PCDHA6
Domain Architecture
Description	Protocadherin alpha 6 precursor (PCDH-alpha6).

PDLI4_HUMAN
θ value	5.27518 (rank : 1624)	NC score	0.044290 (rank : 1191)
Query Neighborhood Hits	1804	Target Neighborhood Hits	245	Shared Neighborhood Hits	114
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PDXL2_HUMAN
θ value	5.27518 (rank : 1625)	NC score	0.005722 (rank : 1666)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PO121_MOUSE
θ value	5.27518 (rank : 1626)	NC score	0.042485 (rank : 1201)
Query Neighborhood Hits	1804	Target Neighborhood Hits	345	Shared Neighborhood Hits	135
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

REXO1_MOUSE
θ value	5.27518 (rank : 1627)	NC score	0.016931 (rank : 1504)
Query Neighborhood Hits	1804	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

RGL2_MOUSE
θ value	5.27518 (rank : 1628)	NC score	0.001351 (rank : 1738)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RIOK2_HUMAN
θ value	5.27518 (rank : 1629)	NC score	0.051177 (rank : 1120)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RTP3_MOUSE
θ value	5.27518 (rank : 1630)	NC score	0.053776 (rank : 1091)
Query Neighborhood Hits	1804	Target Neighborhood Hits	374	Shared Neighborhood Hits	201
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SCAP_HUMAN
θ value	5.27518 (rank : 1631)	NC score	-0.003694 (rank : 1807)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	79
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

SIA7A_MOUSE
θ value	5.27518 (rank : 1632)	NC score	0.012292 (rank : 1576)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

SMRC2_HUMAN
θ value	5.27518 (rank : 1633)	NC score	0.024073 (rank : 1399)
Query Neighborhood Hits	1804	Target Neighborhood Hits	499	Shared Neighborhood Hits	151
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SNTA1_MOUSE
θ value	5.27518 (rank : 1634)	NC score	0.039761 (rank : 1222)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	119
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SRTD1_HUMAN
θ value	5.27518 (rank : 1635)	NC score	0.002755 (rank : 1714)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHV2, Q9BUE7	Gene names	SERTAD1, SEI1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

SYN3_MOUSE
θ value	5.27518 (rank : 1636)	NC score	0.026978 (rank : 1353)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	105
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TBX18_MOUSE
θ value	5.27518 (rank : 1637)	NC score	-0.003103 (rank : 1801)
Query Neighborhood Hits	1804	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

TCF20_MOUSE
θ value	5.27518 (rank : 1638)	NC score	0.032839 (rank : 1279)
Query Neighborhood Hits	1804	Target Neighborhood Hits	396	Shared Neighborhood Hits	156
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

TOB1_MOUSE
θ value	5.27518 (rank : 1639)	NC score	-0.000002 (rank : 1756)
Query Neighborhood Hits	1804	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61471	Gene names	Tob1, Tob, Trob
Domain Architecture
Description	Tob1 protein (Transducer of erbB-2 1).

TSH1_HUMAN
θ value	5.27518 (rank : 1640)	NC score	-0.006563 (rank : 1827)
Query Neighborhood Hits	1804	Target Neighborhood Hits	558	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

TTC28_MOUSE
θ value	5.27518 (rank : 1641)	NC score	0.010553 (rank : 1597)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	56
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

UBP2_HUMAN
θ value	5.27518 (rank : 1642)	NC score	0.003861 (rank : 1689)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	15
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBP2_MOUSE
θ value	5.27518 (rank : 1643)	NC score	0.001048 (rank : 1742)
Query Neighborhood Hits	1804	Target Neighborhood Hits	86	Shared Neighborhood Hits	15
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

UBXD3_MOUSE
θ value	5.27518 (rank : 1644)	NC score	0.004696 (rank : 1681)
Query Neighborhood Hits	1804	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

VRK3_HUMAN
θ value	5.27518 (rank : 1645)	NC score	0.276632 (rank : 845)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	324
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WRIP1_HUMAN
θ value	5.27518 (rank : 1646)	NC score	0.002183 (rank : 1721)
Query Neighborhood Hits	1804	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WWTR1_HUMAN
θ value	5.27518 (rank : 1647)	NC score	0.006414 (rank : 1653)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

ZF106_HUMAN
θ value	5.27518 (rank : 1648)	NC score	0.001718 (rank : 1731)
Query Neighborhood Hits	1804	Target Neighborhood Hits	470	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

ZIM10_MOUSE
θ value	5.27518 (rank : 1649)	NC score	0.019180 (rank : 1466)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	169
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZN452_HUMAN
θ value	5.27518 (rank : 1650)	NC score	-0.006170 (rank : 1825)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	13
SwissProt Accessions	Q6R2W3, Q2NKL9, Q5SRJ3, Q8TCN2, Q96PW3	Gene names	ZNF452, KIAA1925
Domain Architecture	No domain graphic available
Description	Protein ZNF452.

ADA1B_HUMAN
θ value	6.88961 (rank : 1651)	NC score	-0.028806 (rank : 1888)
Query Neighborhood Hits	1804	Target Neighborhood Hits	978	Shared Neighborhood Hits	20
SwissProt Accessions	P35368	Gene names	ADRA1B
Domain Architecture
Description	Alpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B- adrenoreceptor).

ATRX_MOUSE
θ value	6.88961 (rank : 1652)	NC score	0.020223 (rank : 1452)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	146
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

AXN1_HUMAN
θ value	6.88961 (rank : 1653)	NC score	0.004278 (rank : 1685)
Query Neighborhood Hits	1804	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

B3A2_HUMAN
θ value	6.88961 (rank : 1654)	NC score	-0.001179 (rank : 1776)
Query Neighborhood Hits	1804	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

BSPRY_MOUSE
θ value	6.88961 (rank : 1655)	NC score	-0.005161 (rank : 1815)
Query Neighborhood Hits	1804	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

CAF1B_HUMAN
θ value	6.88961 (rank : 1656)	NC score	-0.006079 (rank : 1822)
Query Neighborhood Hits	1804	Target Neighborhood Hits	345	Shared Neighborhood Hits	45
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

CCD21_MOUSE
θ value	6.88961 (rank : 1657)	NC score	0.039003 (rank : 1228)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1135	Shared Neighborhood Hits	189
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCNK_MOUSE
θ value	6.88961 (rank : 1658)	NC score	0.031380 (rank : 1293)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	132
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CD45_HUMAN
θ value	6.88961 (rank : 1659)	NC score	-0.003102 (rank : 1800)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	53
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

CN004_HUMAN
θ value	6.88961 (rank : 1660)	NC score	0.012286 (rank : 1577)
Query Neighborhood Hits	1804	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

CN130_MOUSE
θ value	6.88961 (rank : 1661)	NC score	0.001545 (rank : 1736)
Query Neighborhood Hits	1804	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BU04, Q80UT9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf130 homolog.

CN152_HUMAN
θ value	6.88961 (rank : 1662)	NC score	0.003725 (rank : 1694)
Query Neighborhood Hits	1804	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N9Y4, Q96GY1	Gene names	C14orf152
Domain Architecture	No domain graphic available
Description	Protein C14orf152.

CO9A2_HUMAN
θ value	6.88961 (rank : 1663)	NC score	0.007965 (rank : 1632)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	79
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

COIA1_MOUSE
θ value	6.88961 (rank : 1664)	NC score	0.016012 (rank : 1521)
Query Neighborhood Hits	1804	Target Neighborhood Hits	481	Shared Neighborhood Hits	150
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CRCM1_MOUSE
θ value	6.88961 (rank : 1665)	NC score	-0.000323 (rank : 1762)
Query Neighborhood Hits	1804	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWG9, Q8BUD4, Q8R586	Gene names	Tmem142a, Cracm1, Orai1
Domain Architecture	No domain graphic available
Description	Calcium release-activated calcium channel protein 1 (Transmembrane protein 142A) (Protein orai-1).

CSPG4_HUMAN
θ value	6.88961 (rank : 1666)	NC score	-0.002217 (rank : 1789)
Query Neighborhood Hits	1804	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

DACH1_HUMAN
θ value	6.88961 (rank : 1667)	NC score	0.008161 (rank : 1629)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

DACT1_HUMAN
θ value	6.88961 (rank : 1668)	NC score	0.033419 (rank : 1273)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

DACT1_MOUSE
θ value	6.88961 (rank : 1669)	NC score	0.009225 (rank : 1621)
Query Neighborhood Hits	1804	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

DNMT1_HUMAN
θ value	6.88961 (rank : 1670)	NC score	0.028418 (rank : 1328)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	126
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

DVL2_MOUSE
θ value	6.88961 (rank : 1671)	NC score	0.017557 (rank : 1493)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	125
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

EGLN1_HUMAN
θ value	6.88961 (rank : 1672)	NC score	0.001744 (rank : 1730)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZT9, Q8N3M8, Q9BZS8, Q9BZT0	Gene names	EGLN1, C1orf12
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20).

EMSY_HUMAN
θ value	6.88961 (rank : 1673)	NC score	0.027564 (rank : 1341)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

FOSB_MOUSE
θ value	6.88961 (rank : 1674)	NC score	0.002975 (rank : 1710)
Query Neighborhood Hits	1804	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	P13346	Gene names	Fosb
Domain Architecture	No domain graphic available
Description	Protein fosB.

FOXJ1_MOUSE
θ value	6.88961 (rank : 1675)	NC score	-0.002394 (rank : 1794)
Query Neighborhood Hits	1804	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

GLIS3_HUMAN
θ value	6.88961 (rank : 1676)	NC score	-0.024062 (rank : 1878)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

GLU2B_HUMAN
θ value	6.88961 (rank : 1677)	NC score	0.014512 (rank : 1545)
Query Neighborhood Hits	1804	Target Neighborhood Hits	377	Shared Neighborhood Hits	73
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

HDAC9_MOUSE
θ value	6.88961 (rank : 1678)	NC score	0.012739 (rank : 1572)
Query Neighborhood Hits	1804	Target Neighborhood Hits	186	Shared Neighborhood Hits	36
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

HOME1_MOUSE
θ value	6.88961 (rank : 1679)	NC score	0.014174 (rank : 1549)
Query Neighborhood Hits	1804	Target Neighborhood Hits	630	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

HTRA4_HUMAN
θ value	6.88961 (rank : 1680)	NC score	0.003725 (rank : 1693)
Query Neighborhood Hits	1804	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

JHD1B_MOUSE
θ value	6.88961 (rank : 1681)	NC score	0.000751 (rank : 1747)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	47
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

JPH1_HUMAN
θ value	6.88961 (rank : 1682)	NC score	0.003474 (rank : 1698)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

K2027_HUMAN
θ value	6.88961 (rank : 1683)	NC score	0.034215 (rank : 1266)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	93
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

KCNH2_MOUSE
θ value	6.88961 (rank : 1684)	NC score	0.003584 (rank : 1695)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

LTB1L_MOUSE
θ value	6.88961 (rank : 1685)	NC score	-0.009628 (rank : 1845)
Query Neighborhood Hits	1804	Target Neighborhood Hits	514	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MAP1B_MOUSE
θ value	6.88961 (rank : 1686)	NC score	0.049883 (rank : 1137)
Query Neighborhood Hits	1804	Target Neighborhood Hits	977	Shared Neighborhood Hits	263
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MYO9B_MOUSE
θ value	6.88961 (rank : 1687)	NC score	0.034911 (rank : 1259)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NCOA2_MOUSE
θ value	6.88961 (rank : 1688)	NC score	0.010520 (rank : 1598)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NFM_HUMAN
θ value	6.88961 (rank : 1689)	NC score	0.027234 (rank : 1348)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1328	Shared Neighborhood Hits	285
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NGN1_MOUSE
θ value	6.88961 (rank : 1690)	NC score	-0.006155 (rank : 1823)
Query Neighborhood Hits	1804	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

NOS1_HUMAN
θ value	6.88961 (rank : 1691)	NC score	0.017075 (rank : 1502)
Query Neighborhood Hits	1804	Target Neighborhood Hits	218	Shared Neighborhood Hits	120
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

NPAS2_MOUSE
θ value	6.88961 (rank : 1692)	NC score	-0.001144 (rank : 1775)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NU153_HUMAN
θ value	6.88961 (rank : 1693)	NC score	0.016510 (rank : 1511)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

NUMBL_MOUSE
θ value	6.88961 (rank : 1694)	NC score	0.006744 (rank : 1648)
Query Neighborhood Hits	1804	Target Neighborhood Hits	147	Shared Neighborhood Hits	66
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

PA2G3_HUMAN
θ value	6.88961 (rank : 1695)	NC score	0.003767 (rank : 1691)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ20, O95768	Gene names	PLA2G3
Domain Architecture
Description	Group 3 secretory phospholipase A2 precursor (EC 3.1.1.4) (Group III secretory phospholipase A2) (Phosphatidylcholine 2-acylhydrolase GIII) (GIII sPLA2).

PELP1_MOUSE
θ value	6.88961 (rank : 1696)	NC score	0.042303 (rank : 1205)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	233
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PHF20_MOUSE
θ value	6.88961 (rank : 1697)	NC score	0.021368 (rank : 1434)
Query Neighborhood Hits	1804	Target Neighborhood Hits	513	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

PKHA6_MOUSE
θ value	6.88961 (rank : 1698)	NC score	0.037060 (rank : 1243)
Query Neighborhood Hits	1804	Target Neighborhood Hits	591	Shared Neighborhood Hits	179
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

POLK_HUMAN
θ value	6.88961 (rank : 1699)	NC score	0.002642 (rank : 1717)
Query Neighborhood Hits	1804	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

PP2CG_HUMAN
θ value	6.88961 (rank : 1700)	NC score	-0.001045 (rank : 1774)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	25
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

RAI14_MOUSE
θ value	6.88961 (rank : 1701)	NC score	0.028430 (rank : 1327)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1505	Shared Neighborhood Hits	199
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RAI2_HUMAN
θ value	6.88961 (rank : 1702)	NC score	0.003277 (rank : 1702)
Query Neighborhood Hits	1804	Target Neighborhood Hits	53	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5P3, Q8N6X7	Gene names	RAI2
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 2.

RHG06_HUMAN
θ value	6.88961 (rank : 1703)	NC score	-0.000940 (rank : 1773)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RN169_HUMAN
θ value	6.88961 (rank : 1704)	NC score	0.001533 (rank : 1737)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RUNX3_MOUSE
θ value	6.88961 (rank : 1705)	NC score	0.020422 (rank : 1451)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

RUSC2_MOUSE
θ value	6.88961 (rank : 1706)	NC score	0.025042 (rank : 1385)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	139
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SELPL_MOUSE
θ value	6.88961 (rank : 1707)	NC score	0.070018 (rank : 963)
Query Neighborhood Hits	1804	Target Neighborhood Hits	588	Shared Neighborhood Hits	269
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SFRIP_HUMAN
θ value	6.88961 (rank : 1708)	NC score	0.052182 (rank : 1105)
Query Neighborhood Hits	1804	Target Neighborhood Hits	530	Shared Neighborhood Hits	187
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SH22A_MOUSE
θ value	6.88961 (rank : 1709)	NC score	0.026249 (rank : 1368)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SIM2_HUMAN
θ value	6.88961 (rank : 1710)	NC score	-0.002313 (rank : 1791)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SYMPK_HUMAN
θ value	6.88961 (rank : 1711)	NC score	0.009514 (rank : 1616)
Query Neighborhood Hits	1804	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

TAB3_HUMAN
θ value	6.88961 (rank : 1712)	NC score	0.007063 (rank : 1645)
Query Neighborhood Hits	1804	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

TACC2_MOUSE
θ value	6.88961 (rank : 1713)	NC score	0.037357 (rank : 1241)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	197
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TXLNB_MOUSE
θ value	6.88961 (rank : 1714)	NC score	0.031363 (rank : 1294)
Query Neighborhood Hits	1804	Target Neighborhood Hits	640	Shared Neighborhood Hits	116
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

UBQL3_MOUSE
θ value	6.88961 (rank : 1715)	NC score	0.002781 (rank : 1713)
Query Neighborhood Hits	1804	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C5U9	Gene names	Ubqln3
Domain Architecture
Description	Ubiquilin-3.

WDR33_HUMAN
θ value	6.88961 (rank : 1716)	NC score	-0.000751 (rank : 1769)
Query Neighborhood Hits	1804	Target Neighborhood Hits	638	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

ZCH10_HUMAN
θ value	6.88961 (rank : 1717)	NC score	0.011736 (rank : 1582)
Query Neighborhood Hits	1804	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

ZCPW1_MOUSE
θ value	6.88961 (rank : 1718)	NC score	0.026774 (rank : 1359)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

ZN516_MOUSE
θ value	6.88961 (rank : 1719)	NC score	-0.009834 (rank : 1848)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1197	Shared Neighborhood Hits	268
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZN553_HUMAN
θ value	6.88961 (rank : 1720)	NC score	-0.026176 (rank : 1886)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	Q96MX3, Q4G0R3, Q69YP3, Q96IL9	Gene names	ZNF553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ABCF1_MOUSE
θ value	8.99809 (rank : 1721)	NC score	0.003326 (rank : 1701)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	64
SwissProt Accessions	Q6P542, Q6NV71	Gene names	Abcf1
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1.

ABI3_MOUSE
θ value	8.99809 (rank : 1722)	NC score	0.017457 (rank : 1495)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ACV1C_MOUSE
θ value	8.99809 (rank : 1723)	NC score	0.561824 (rank : 803)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	700
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ADA12_HUMAN
θ value	8.99809 (rank : 1724)	NC score	-0.006601 (rank : 1828)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	24
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

AIRE_MOUSE
θ value	8.99809 (rank : 1725)	NC score	0.006531 (rank : 1652)
Query Neighborhood Hits	1804	Target Neighborhood Hits	196	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

ANR11_HUMAN
θ value	8.99809 (rank : 1726)	NC score	0.038868 (rank : 1230)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1289	Shared Neighborhood Hits	312
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ARI3A_HUMAN
θ value	8.99809 (rank : 1727)	NC score	0.007231 (rank : 1640)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

ASPP1_MOUSE
θ value	8.99809 (rank : 1728)	NC score	0.065217 (rank : 996)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1244	Shared Neighborhood Hits	370
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BRD3_HUMAN
θ value	8.99809 (rank : 1729)	NC score	0.018056 (rank : 1485)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	105
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

BUB1_HUMAN
θ value	8.99809 (rank : 1730)	NC score	0.428394 (rank : 833)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	425
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CABYR_MOUSE
θ value	8.99809 (rank : 1731)	NC score	0.008356 (rank : 1627)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

CC040_MOUSE
θ value	8.99809 (rank : 1732)	NC score	0.000527 (rank : 1750)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWU3, Q99KY5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf40 homolog precursor.

CCD41_MOUSE
θ value	8.99809 (rank : 1733)	NC score	0.034326 (rank : 1264)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1399	Shared Neighborhood Hits	179
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CECR2_HUMAN
θ value	8.99809 (rank : 1734)	NC score	0.029124 (rank : 1321)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEP63_HUMAN
θ value	8.99809 (rank : 1735)	NC score	0.027628 (rank : 1339)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	130
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CR2_MOUSE
θ value	8.99809 (rank : 1736)	NC score	-0.006329 (rank : 1826)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P19070	Gene names	Cr2
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (CD21 antigen).

CROCC_MOUSE
θ value	8.99809 (rank : 1737)	NC score	0.030600 (rank : 1300)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1460	Shared Neighborhood Hits	178
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CS016_HUMAN
θ value	8.99809 (rank : 1738)	NC score	0.044124 (rank : 1194)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	147
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

DAB2_MOUSE
θ value	8.99809 (rank : 1739)	NC score	0.013977 (rank : 1551)
Query Neighborhood Hits	1804	Target Neighborhood Hits	163	Shared Neighborhood Hits	72
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DCBD1_MOUSE
θ value	8.99809 (rank : 1740)	NC score	-0.003483 (rank : 1804)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D4J3, Q8R327, Q9D696	Gene names	Dcbld1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

E41LB_HUMAN
θ value	8.99809 (rank : 1741)	NC score	-0.004169 (rank : 1811)
Query Neighborhood Hits	1804	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

EHMT1_HUMAN
θ value	8.99809 (rank : 1742)	NC score	0.013619 (rank : 1560)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

FMN1A_MOUSE
θ value	8.99809 (rank : 1743)	NC score	0.023249 (rank : 1411)
Query Neighborhood Hits	1804	Target Neighborhood Hits	423	Shared Neighborhood Hits	141
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FOXM1_MOUSE
θ value	8.99809 (rank : 1744)	NC score	-0.001391 (rank : 1779)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	37
SwissProt Accessions	O08696	Gene names	Foxm1, Fkh16
Domain Architecture
Description	Forkhead box protein M1 (Forkhead homolog 16) (Winged-helix transcription factor Trident).

FXR2_HUMAN
θ value	8.99809 (rank : 1745)	NC score	0.000051 (rank : 1755)
Query Neighborhood Hits	1804	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

GGA1_HUMAN
θ value	8.99809 (rank : 1746)	NC score	0.007552 (rank : 1635)
Query Neighborhood Hits	1804	Target Neighborhood Hits	169	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GOGA3_HUMAN
θ value	8.99809 (rank : 1747)	NC score	0.028303 (rank : 1329)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1317	Shared Neighborhood Hits	175
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GON4L_HUMAN
θ value	8.99809 (rank : 1748)	NC score	0.025208 (rank : 1381)
Query Neighborhood Hits	1804	Target Neighborhood Hits	555	Shared Neighborhood Hits	191
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

H13_HUMAN
θ value	8.99809 (rank : 1749)	NC score	0.012872 (rank : 1569)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	33
SwissProt Accessions	P16402	Gene names	HIST1H1D, H1F3
Domain Architecture
Description	Histone H1.3 (Histone H1c).

HCN2_MOUSE
θ value	8.99809 (rank : 1750)	NC score	0.022170 (rank : 1426)
Query Neighborhood Hits	1804	Target Neighborhood Hits	278	Shared Neighborhood Hits	130
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HSF1_MOUSE
θ value	8.99809 (rank : 1751)	NC score	0.020925 (rank : 1442)
Query Neighborhood Hits	1804	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

HXA3_MOUSE
θ value	8.99809 (rank : 1752)	NC score	-0.005977 (rank : 1820)
Query Neighborhood Hits	1804	Target Neighborhood Hits	558	Shared Neighborhood Hits	125
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

ILK_MOUSE
θ value	8.99809 (rank : 1753)	NC score	0.422564 (rank : 836)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	604
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

K0513_MOUSE
θ value	8.99809 (rank : 1754)	NC score	0.001675 (rank : 1734)
Query Neighborhood Hits	1804	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

KCNK4_MOUSE
θ value	8.99809 (rank : 1755)	NC score	0.000752 (rank : 1746)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	40
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

KCNN1_HUMAN
θ value	8.99809 (rank : 1756)	NC score	-0.000827 (rank : 1770)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q92952	Gene names	KCNN1, SK
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 1 (SK1).

KCT2_MOUSE
θ value	8.99809 (rank : 1757)	NC score	0.004039 (rank : 1686)
Query Neighborhood Hits	1804	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

LCP2_MOUSE
θ value	8.99809 (rank : 1758)	NC score	0.032861 (rank : 1278)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LIRB5_HUMAN
θ value	8.99809 (rank : 1759)	NC score	-0.005440 (rank : 1817)
Query Neighborhood Hits	1804	Target Neighborhood Hits	100	Shared Neighborhood Hits	8
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

LMBL3_MOUSE
θ value	8.99809 (rank : 1760)	NC score	0.010408 (rank : 1600)
Query Neighborhood Hits	1804	Target Neighborhood Hits	212	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

LRTM3_MOUSE
θ value	8.99809 (rank : 1761)	NC score	-0.008580 (rank : 1841)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

MA1C1_HUMAN
θ value	8.99809 (rank : 1762)	NC score	-0.000854 (rank : 1771)
Query Neighborhood Hits	1804	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

MAP2_MOUSE
θ value	8.99809 (rank : 1763)	NC score	0.024465 (rank : 1394)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	111
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

MEF2C_HUMAN
θ value	8.99809 (rank : 1764)	NC score	0.005758 (rank : 1665)
Query Neighborhood Hits	1804	Target Neighborhood Hits	90	Shared Neighborhood Hits	40
SwissProt Accessions	Q06413	Gene names	MEF2C
Domain Architecture
Description	Myocyte-specific enhancer factor 2C.

MNDA_HUMAN
θ value	8.99809 (rank : 1765)	NC score	0.004633 (rank : 1683)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

MNT_HUMAN
θ value	8.99809 (rank : 1766)	NC score	0.028456 (rank : 1326)
Query Neighborhood Hits	1804	Target Neighborhood Hits	496	Shared Neighborhood Hits	162
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MPP4_HUMAN
θ value	8.99809 (rank : 1767)	NC score	0.038840 (rank : 1231)
Query Neighborhood Hits	1804	Target Neighborhood Hits	205	Shared Neighborhood Hits	114
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MYCB2_MOUSE
θ value	8.99809 (rank : 1768)	NC score	0.014999 (rank : 1532)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYC_MOUSE
θ value	8.99809 (rank : 1769)	NC score	-0.000510 (rank : 1765)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

NEUM_MOUSE
θ value	8.99809 (rank : 1770)	NC score	0.029530 (rank : 1312)
Query Neighborhood Hits	1804	Target Neighborhood Hits	149	Shared Neighborhood Hits	76
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

PCDA2_HUMAN
θ value	8.99809 (rank : 1771)	NC score	-0.008941 (rank : 1842)
Query Neighborhood Hits	1804	Target Neighborhood Hits	192	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

PDLI3_MOUSE
θ value	8.99809 (rank : 1772)	NC score	0.028171 (rank : 1331)
Query Neighborhood Hits	1804	Target Neighborhood Hits	197	Shared Neighborhood Hits	92
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDLI5_HUMAN
θ value	8.99809 (rank : 1773)	NC score	0.030584 (rank : 1301)
Query Neighborhood Hits	1804	Target Neighborhood Hits	322	Shared Neighborhood Hits	142
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PHC2_HUMAN
θ value	8.99809 (rank : 1774)	NC score	0.035612 (rank : 1253)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	172
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

R3HD2_MOUSE
θ value	8.99809 (rank : 1775)	NC score	0.042256 (rank : 1208)
Query Neighborhood Hits	1804	Target Neighborhood Hits	397	Shared Neighborhood Hits	163
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RD23B_MOUSE
θ value	8.99809 (rank : 1776)	NC score	0.012034 (rank : 1579)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	P54728	Gene names	Rad23b, Mhr23b
Domain Architecture
Description	UV excision repair protein RAD23 homolog B (mHR23B) (XP-C repair- complementing complex 58 kDa protein) (p58).

RIP_MOUSE
θ value	8.99809 (rank : 1777)	NC score	0.001676 (rank : 1733)
Query Neighborhood Hits	1804	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWY9	Gene names	Rpain, Rip
Domain Architecture	No domain graphic available
Description	RPA-interacting protein.

RNF12_MOUSE
θ value	8.99809 (rank : 1778)	NC score	-0.003144 (rank : 1802)
Query Neighborhood Hits	1804	Target Neighborhood Hits	159	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

RRAS_MOUSE
θ value	8.99809 (rank : 1779)	NC score	-0.016055 (rank : 1866)
Query Neighborhood Hits	1804	Target Neighborhood Hits	272	Shared Neighborhood Hits	8
SwissProt Accessions	P10833	Gene names	Rras
Domain Architecture
Description	Ras-related protein R-Ras (P23).

SAPS1_MOUSE
θ value	8.99809 (rank : 1780)	NC score	0.008411 (rank : 1626)
Query Neighborhood Hits	1804	Target Neighborhood Hits	144	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

SCEL_MOUSE
θ value	8.99809 (rank : 1781)	NC score	0.002401 (rank : 1719)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQG3, Q9CTT9	Gene names	Scel
Domain Architecture
Description	Sciellin.

SF3A2_MOUSE
θ value	8.99809 (rank : 1782)	NC score	0.027890 (rank : 1338)
Query Neighborhood Hits	1804	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SFR12_MOUSE
θ value	8.99809 (rank : 1783)	NC score	0.037822 (rank : 1237)
Query Neighborhood Hits	1804	Target Neighborhood Hits	486	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

SI1L2_MOUSE
θ value	8.99809 (rank : 1784)	NC score	0.007939 (rank : 1633)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	50
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SMC4_HUMAN
θ value	8.99809 (rank : 1785)	NC score	0.013289 (rank : 1565)
Query Neighborhood Hits	1804	Target Neighborhood Hits	937	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SMCA2_HUMAN
θ value	8.99809 (rank : 1786)	NC score	0.010256 (rank : 1604)
Query Neighborhood Hits	1804	Target Neighborhood Hits	503	Shared Neighborhood Hits	137
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SMRC1_MOUSE
θ value	8.99809 (rank : 1787)	NC score	0.013769 (rank : 1555)
Query Neighborhood Hits	1804	Target Neighborhood Hits	459	Shared Neighborhood Hits	138
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

SNIP_MOUSE
θ value	8.99809 (rank : 1788)	NC score	0.021858 (rank : 1428)
Query Neighborhood Hits	1804	Target Neighborhood Hits	319	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SON_MOUSE
θ value	8.99809 (rank : 1789)	NC score	0.061167 (rank : 1031)
Query Neighborhood Hits	1804	Target Neighborhood Hits	957	Shared Neighborhood Hits	345
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SYNJ2_HUMAN
θ value	8.99809 (rank : 1790)	NC score	0.023311 (rank : 1406)
Query Neighborhood Hits	1804	Target Neighborhood Hits	136	Shared Neighborhood Hits	61
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

TAF6_HUMAN
θ value	8.99809 (rank : 1791)	NC score	0.013761 (rank : 1556)
Query Neighborhood Hits	1804	Target Neighborhood Hits	127	Shared Neighborhood Hits	53
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

TMG4_MOUSE
θ value	8.99809 (rank : 1792)	NC score	-0.002175 (rank : 1787)
Query Neighborhood Hits	1804	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

TMM29_HUMAN
θ value	8.99809 (rank : 1793)	NC score	0.013822 (rank : 1554)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDB6, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q9UI49	Gene names	TMEM29
Domain Architecture	No domain graphic available
Description	Transmembrane protein 29.

TNKS1_HUMAN
θ value	8.99809 (rank : 1794)	NC score	0.017972 (rank : 1486)
Query Neighborhood Hits	1804	Target Neighborhood Hits	477	Shared Neighborhood Hits	110
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

TOX_MOUSE
θ value	8.99809 (rank : 1795)	NC score	0.001226 (rank : 1740)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TREF1_MOUSE
θ value	8.99809 (rank : 1796)	NC score	-0.000444 (rank : 1763)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

TRI66_MOUSE
θ value	8.99809 (rank : 1797)	NC score	0.016398 (rank : 1515)
Query Neighborhood Hits	1804	Target Neighborhood Hits	491	Shared Neighborhood Hits	133
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TRIM8_MOUSE
θ value	8.99809 (rank : 1798)	NC score	-0.002412 (rank : 1795)
Query Neighborhood Hits	1804	Target Neighborhood Hits	674	Shared Neighborhood Hits	88
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

UBP36_HUMAN
θ value	8.99809 (rank : 1799)	NC score	0.003196 (rank : 1705)
Query Neighborhood Hits	1804	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

VAT1_MOUSE
θ value	8.99809 (rank : 1800)	NC score	-0.002358 (rank : 1793)
Query Neighborhood Hits	1804	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VGLL4_HUMAN
θ value	8.99809 (rank : 1801)	NC score	0.009480 (rank : 1617)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q14135, Q7L5V0, Q9BQ78	Gene names	VGLL4, KIAA0121
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

WTAP_HUMAN
θ value	8.99809 (rank : 1802)	NC score	0.010213 (rank : 1607)
Query Neighborhood Hits	1804	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

ZN318_MOUSE
θ value	8.99809 (rank : 1803)	NC score	0.029775 (rank : 1309)
Query Neighborhood Hits	1804	Target Neighborhood Hits	642	Shared Neighborhood Hits	161
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

ZN553_MOUSE
θ value	8.99809 (rank : 1804)	NC score	-0.026338 (rank : 1887)
Query Neighborhood Hits	1804	Target Neighborhood Hits	744	Shared Neighborhood Hits	45
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ACINU_HUMAN
θ value	θ > 10 (rank : 1805)	NC score	0.057991 (rank : 1060)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	229
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACV1C_HUMAN
θ value	θ > 10 (rank : 1806)	NC score	0.555665 (rank : 804)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	693
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

AFAD_HUMAN
θ value	θ > 10 (rank : 1807)	NC score	0.058333 (rank : 1057)
Query Neighborhood Hits	1804	Target Neighborhood Hits	689	Shared Neighborhood Hits	204
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1808)	NC score	0.097828 (rank : 891)
Query Neighborhood Hits	1804	Target Neighborhood Hits	208	Shared Neighborhood Hits	124
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1809)	NC score	0.080113 (rank : 930)
Query Neighborhood Hits	1804	Target Neighborhood Hits	202	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CHIN_HUMAN
θ value	θ > 10 (rank : 1810)	NC score	0.095663 (rank : 899)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1811)	NC score	0.096570 (rank : 898)
Query Neighborhood Hits	1804	Target Neighborhood Hits	229	Shared Neighborhood Hits	77
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1812)	NC score	0.097444 (rank : 894)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	75
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1813)	NC score	0.092631 (rank : 905)
Query Neighborhood Hits	1804	Target Neighborhood Hits	130	Shared Neighborhood Hits	48
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CK024_HUMAN
θ value	θ > 10 (rank : 1814)	NC score	0.060958 (rank : 1033)
Query Neighborhood Hits	1804	Target Neighborhood Hits	408	Shared Neighborhood Hits	199
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CK024_MOUSE
θ value	θ > 10 (rank : 1815)	NC score	0.057313 (rank : 1066)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	131
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

DAPP1_HUMAN
θ value	θ > 10 (rank : 1816)	NC score	0.050423 (rank : 1129)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCC_MOUSE
θ value	θ > 10 (rank : 1817)	NC score	0.058968 (rank : 1051)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	289
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DGKA_HUMAN
θ value	θ > 10 (rank : 1818)	NC score	0.058258 (rank : 1058)
Query Neighborhood Hits	1804	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKB_HUMAN
θ value	θ > 10 (rank : 1819)	NC score	0.076371 (rank : 942)
Query Neighborhood Hits	1804	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 1820)	NC score	0.099532 (rank : 888)
Query Neighborhood Hits	1804	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKG_HUMAN
θ value	θ > 10 (rank : 1821)	NC score	0.068030 (rank : 977)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKG_MOUSE
θ value	θ > 10 (rank : 1822)	NC score	0.072927 (rank : 951)
Query Neighborhood Hits	1804	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1823)	NC score	0.094388 (rank : 900)
Query Neighborhood Hits	1804	Target Neighborhood Hits	255	Shared Neighborhood Hits	88
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	θ > 10 (rank : 1824)	NC score	0.053279 (rank : 1094)
Query Neighborhood Hits	1804	Target Neighborhood Hits	378	Shared Neighborhood Hits	147
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1825)	NC score	0.097567 (rank : 893)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	47
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1826)	NC score	0.062630 (rank : 1019)
Query Neighborhood Hits	1804	Target Neighborhood Hits	304	Shared Neighborhood Hits	89
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1827)	NC score	0.061419 (rank : 1027)
Query Neighborhood Hits	1804	Target Neighborhood Hits	297	Shared Neighborhood Hits	84
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1828)	NC score	0.066103 (rank : 991)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1829)	NC score	0.065115 (rank : 1000)
Query Neighborhood Hits	1804	Target Neighborhood Hits	309	Shared Neighborhood Hits	93
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 1830)	NC score	0.063322 (rank : 1011)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	89
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1831)	NC score	0.063245 (rank : 1012)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 1832)	NC score	0.134277 (rank : 857)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

ILK1_HUMAN
θ value	θ > 10 (rank : 1833)	NC score	0.424234 (rank : 835)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	603
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 1834)	NC score	0.412654 (rank : 837)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	595
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

INVO_HUMAN
θ value	θ > 10 (rank : 1835)	NC score	0.050483 (rank : 1128)
Query Neighborhood Hits	1804	Target Neighborhood Hits	636	Shared Neighborhood Hits	136
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

ITSN1_HUMAN
θ value	θ > 10 (rank : 1836)	NC score	0.056817 (rank : 1069)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1757	Shared Neighborhood Hits	315
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 1837)	NC score	0.057342 (rank : 1065)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1669	Shared Neighborhood Hits	317
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 1838)	NC score	0.053580 (rank : 1093)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1173	Shared Neighborhood Hits	198
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 1839)	NC score	0.050291 (rank : 1130)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1371	Shared Neighborhood Hits	224
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MAP4_HUMAN
θ value	θ > 10 (rank : 1840)	NC score	0.061513 (rank : 1026)
Query Neighborhood Hits	1804	Target Neighborhood Hits	428	Shared Neighborhood Hits	199
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NCK1_HUMAN
θ value	θ > 10 (rank : 1841)	NC score	0.059565 (rank : 1048)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	88
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1842)	NC score	0.059698 (rank : 1045)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	82
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NRBP_HUMAN
θ value	θ > 10 (rank : 1843)	NC score	0.455151 (rank : 826)
Query Neighborhood Hits	1804	Target Neighborhood Hits	448	Shared Neighborhood Hits	423
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 1844)	NC score	0.452792 (rank : 827)
Query Neighborhood Hits	1804	Target Neighborhood Hits	442	Shared Neighborhood Hits	417
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NTKL_HUMAN
θ value	θ > 10 (rank : 1845)	NC score	0.249170 (rank : 847)
Query Neighborhood Hits	1804	Target Neighborhood Hits	266	Shared Neighborhood Hits	230
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 1846)	NC score	0.328443 (rank : 842)
Query Neighborhood Hits	1804	Target Neighborhood Hits	326	Shared Neighborhood Hits	294
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

OGFR_MOUSE
θ value	θ > 10 (rank : 1847)	NC score	0.051557 (rank : 1113)
Query Neighborhood Hits	1804	Target Neighborhood Hits	584	Shared Neighborhood Hits	241
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PACE1_HUMAN
θ value	θ > 10 (rank : 1848)	NC score	0.065238 (rank : 995)
Query Neighborhood Hits	1804	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1849)	NC score	0.068395 (rank : 974)
Query Neighborhood Hits	1804	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PRPK_HUMAN
θ value	θ > 10 (rank : 1850)	NC score	0.134832 (rank : 855)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	128
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1851)	NC score	0.137886 (rank : 853)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	132
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PXK_HUMAN
θ value	θ > 10 (rank : 1852)	NC score	0.159210 (rank : 851)
Query Neighborhood Hits	1804	Target Neighborhood Hits	216	Shared Neighborhood Hits	144
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 1853)	NC score	0.197929 (rank : 849)
Query Neighborhood Hits	1804	Target Neighborhood Hits	320	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RASA1_HUMAN
θ value	θ > 10 (rank : 1854)	NC score	0.058681 (rank : 1053)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	73
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1855)	NC score	0.088726 (rank : 910)
Query Neighborhood Hits	1804	Target Neighborhood Hits	62	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1856)	NC score	0.108259 (rank : 873)
Query Neighborhood Hits	1804	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 1857)	NC score	0.056356 (rank : 1075)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	141
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RGS3_HUMAN
θ value	θ > 10 (rank : 1858)	NC score	0.092820 (rank : 904)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1375	Shared Neighborhood Hits	541
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SAPS1_HUMAN
θ value	θ > 10 (rank : 1859)	NC score	0.057925 (rank : 1063)
Query Neighborhood Hits	1804	Target Neighborhood Hits	704	Shared Neighborhood Hits	340
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SH21A_MOUSE
θ value	θ > 10 (rank : 1860)	NC score	0.052870 (rank : 1101)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1861)	NC score	0.052479 (rank : 1103)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1862)	NC score	0.058466 (rank : 1056)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SLAP1_HUMAN
θ value	θ > 10 (rank : 1863)	NC score	0.082809 (rank : 922)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1864)	NC score	0.081490 (rank : 929)
Query Neighborhood Hits	1804	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1865)	NC score	0.083577 (rank : 920)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1866)	NC score	0.086284 (rank : 914)
Query Neighborhood Hits	1804	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

STAC3_HUMAN
θ value	θ > 10 (rank : 1867)	NC score	0.100730 (rank : 883)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	88
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1868)	NC score	0.102369 (rank : 880)
Query Neighborhood Hits	1804	Target Neighborhood Hits	232	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1869)	NC score	0.103177 (rank : 878)
Query Neighborhood Hits	1804	Target Neighborhood Hits	276	Shared Neighborhood Hits	104
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1870)	NC score	0.109251 (rank : 872)
Query Neighborhood Hits	1804	Target Neighborhood Hits	268	Shared Neighborhood Hits	102
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STK31_HUMAN
θ value	θ > 10 (rank : 1871)	NC score	0.327075 (rank : 843)
Query Neighborhood Hits	1804	Target Neighborhood Hits	570	Shared Neighborhood Hits	385
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1872)	NC score	0.271357 (rank : 846)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	316
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

T22D4_HUMAN
θ value	θ > 10 (rank : 1873)	NC score	0.051734 (rank : 1108)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

TAF4_HUMAN
θ value	θ > 10 (rank : 1874)	NC score	0.058921 (rank : 1052)
Query Neighborhood Hits	1804	Target Neighborhood Hits	687	Shared Neighborhood Hits	229
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARSH_HUMAN
θ value	θ > 10 (rank : 1875)	NC score	0.086260 (rank : 915)
Query Neighborhood Hits	1804	Target Neighborhood Hits	768	Shared Neighborhood Hits	339
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TOPK_HUMAN
θ value	θ > 10 (rank : 1876)	NC score	0.572196 (rank : 801)
Query Neighborhood Hits	1804	Target Neighborhood Hits	605	Shared Neighborhood Hits	593
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

UN13A_HUMAN
θ value	θ > 10 (rank : 1877)	NC score	0.106157 (rank : 875)
Query Neighborhood Hits	1804	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1878)	NC score	0.102739 (rank : 879)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1879)	NC score	0.099778 (rank : 886)
Query Neighborhood Hits	1804	Target Neighborhood Hits	210	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1880)	NC score	0.079363 (rank : 932)
Query Neighborhood Hits	1804	Target Neighborhood Hits	453	Shared Neighborhood Hits	123
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1881)	NC score	0.077332 (rank : 939)
Query Neighborhood Hits	1804	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1882)	NC score	0.079628 (rank : 931)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1883)	NC score	0.078732 (rank : 934)
Query Neighborhood Hits	1804	Target Neighborhood Hits	404	Shared Neighborhood Hits	115
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1884)	NC score	0.082019 (rank : 927)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	117
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1885)	NC score	0.077826 (rank : 938)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	115
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VRK3_MOUSE
θ value	θ > 10 (rank : 1886)	NC score	0.245247 (rank : 848)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	325
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ZC313_HUMAN
θ value	θ > 10 (rank : 1887)	NC score	0.056026 (rank : 1076)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	170
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZN750_MOUSE
θ value	θ > 10 (rank : 1888)	NC score	0.051322 (rank : 1117)
Query Neighborhood Hits	1804	Target Neighborhood Hits	346	Shared Neighborhood Hits	169
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

Hits sorted by NC score

MAST4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 6)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1804
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MAST1_HUMAN
NC score	0.980578 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1146	Shared Neighborhood Hits	1021
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST3_HUMAN
NC score	0.980381 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1128	Shared Neighborhood Hits	1026
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST1_MOUSE
NC score	0.980081 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	1010
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_MOUSE
NC score	0.980046 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1110	Shared Neighborhood Hits	1009
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.980010 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1189	Shared Neighborhood Hits	1031
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KAPCG_HUMAN
NC score	0.956137 (rank : 7)	θ value	3.0428e-56 (rank : 33)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	830
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KAPCA_HUMAN
NC score	0.956058 (rank : 8)	θ value	5.0155e-59 (rank : 15)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	829
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
NC score	0.955915 (rank : 9)	θ value	5.0155e-59 (rank : 16)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	827
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_MOUSE
NC score	0.955720 (rank : 10)	θ value	3.84025e-59 (rank : 13)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_HUMAN
NC score	0.955535 (rank : 11)	θ value	3.25095e-58 (rank : 20)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

PRKX_HUMAN
NC score	0.954627 (rank : 12)	θ value	5.19021e-56 (rank : 34)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KS6B2_MOUSE
NC score	0.954145 (rank : 13)	θ value	2.41096e-53 (rank : 50)
Query Neighborhood Hits	1804	Target Neighborhood Hits	871	Shared Neighborhood Hits	847
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6B2_HUMAN
NC score	0.954010 (rank : 14)	θ value	1.84601e-53 (rank : 48)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PRKX_MOUSE
NC score	0.953647 (rank : 15)	θ value	9.16162e-53 (rank : 53)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	833
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KS6B1_HUMAN
NC score	0.953535 (rank : 16)	θ value	2.84797e-54 (rank : 41)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.953517 (rank : 17)	θ value	1.08223e-53 (rank : 47)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

AKT3_HUMAN
NC score	0.952630 (rank : 18)	θ value	6.55044e-59 (rank : 17)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.952626 (rank : 19)	θ value	1.45929e-58 (rank : 19)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

AKT2_HUMAN
NC score	0.951971 (rank : 20)	θ value	6.99855e-61 (rank : 10)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	827
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
NC score	0.951916 (rank : 21)	θ value	5.35859e-61 (rank : 8)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	827
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

SGK2_HUMAN
NC score	0.951807 (rank : 22)	θ value	2.58187e-47 (rank : 78)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

PRKY_HUMAN
NC score	0.951741 (rank : 23)	θ value	1.32601e-43 (rank : 90)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	834
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

SGK2_MOUSE
NC score	0.951673 (rank : 24)	θ value	3.15612e-45 (rank : 86)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	824
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK1_HUMAN
NC score	0.951576 (rank : 25)	θ value	4.40402e-47 (rank : 79)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	831
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
NC score	0.951445 (rank : 26)	θ value	1.28137e-46 (rank : 81)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AKT1_MOUSE
NC score	0.950758 (rank : 27)	θ value	1.45929e-58 (rank : 18)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	826
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.950696 (rank : 28)	θ value	1.7238e-59 (rank : 12)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	828
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KS6A5_MOUSE
NC score	0.949690 (rank : 29)	θ value	1.85029e-45 (rank : 85)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

PDPK1_MOUSE
NC score	0.949483 (rank : 30)	θ value	5.95217e-44 (rank : 89)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.949439 (rank : 31)	θ value	1.73182e-43 (rank : 91)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

ST38L_HUMAN
NC score	0.949034 (rank : 32)	θ value	3.84025e-59 (rank : 14)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	795
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_MOUSE
NC score	0.948571 (rank : 33)	θ value	8.00737e-57 (rank : 30)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	801
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.948557 (rank : 34)	θ value	4.69435e-57 (rank : 28)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	801
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KS6A4_HUMAN
NC score	0.948265 (rank : 35)	θ value	6.14528e-49 (rank : 67)
Query Neighborhood Hits	1804	Target Neighborhood Hits	868	Shared Neighborhood Hits	844
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
NC score	0.947857 (rank : 36)	θ value	3.04986e-48 (rank : 73)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
NC score	0.947679 (rank : 37)	θ value	2.85459e-46 (rank : 83)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	837
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

SGK3_MOUSE
NC score	0.947633 (rank : 38)	θ value	3.04986e-48 (rank : 74)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	826
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SGK3_HUMAN
NC score	0.947522 (rank : 39)	θ value	4.40402e-47 (rank : 80)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	825
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KPCI_MOUSE
NC score	0.947002 (rank : 40)	θ value	8.02596e-49 (rank : 68)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.946969 (rank : 41)	θ value	3.98324e-48 (rank : 76)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	837
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

PKN3_HUMAN
NC score	0.946816 (rank : 42)	θ value	5.55816e-50 (rank : 61)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KS6A6_HUMAN
NC score	0.946806 (rank : 43)	θ value	4.69435e-57 (rank : 27)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	837
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

ST38L_MOUSE
NC score	0.946471 (rank : 44)	θ value	1.01059e-59 (rank : 11)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	789
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

DMPK_HUMAN
NC score	0.945810 (rank : 45)	θ value	6.34462e-54 (rank : 44)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	831
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KS6A1_HUMAN
NC score	0.945762 (rank : 46)	θ value	4.69435e-57 (rank : 26)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

ST32A_HUMAN
NC score	0.945643 (rank : 47)	θ value	3.27365e-34 (rank : 98)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

PKN3_MOUSE
NC score	0.945609 (rank : 48)	θ value	6.56568e-51 (rank : 56)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	887
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

DMPK_MOUSE
NC score	0.945557 (rank : 49)	θ value	2.41096e-53 (rank : 49)
Query Neighborhood Hits	1804	Target Neighborhood Hits	908	Shared Neighborhood Hits	825
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KS6A2_MOUSE
NC score	0.945552 (rank : 50)	θ value	1.51013e-55 (rank : 37)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	839
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

ST32A_MOUSE
NC score	0.945413 (rank : 51)	θ value	6.59618e-35 (rank : 96)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

KS6A2_HUMAN
NC score	0.945330 (rank : 52)	θ value	6.77864e-56 (rank : 35)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	838
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
NC score	0.945161 (rank : 53)	θ value	1.23536e-57 (rank : 23)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	839
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A1_MOUSE
NC score	0.945150 (rank : 54)	θ value	3.84914e-51 (rank : 55)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A3_MOUSE
NC score	0.945140 (rank : 55)	θ value	1.23536e-57 (rank : 24)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	839
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PKN2_MOUSE
NC score	0.945001 (rank : 56)	θ value	4.85792e-54 (rank : 43)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	827
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

KPCZ_MOUSE
NC score	0.944744 (rank : 57)	θ value	5.20228e-48 (rank : 77)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	833
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.944721 (rank : 58)	θ value	1.788e-48 (rank : 71)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

PKN2_HUMAN
NC score	0.944713 (rank : 59)	θ value	8.28633e-54 (rank : 45)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	828
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN1_HUMAN
NC score	0.944698 (rank : 60)	θ value	2.41096e-53 (rank : 51)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

ST32B_HUMAN
NC score	0.944649 (rank : 61)	θ value	2.77131e-33 (rank : 102)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	824
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32C_MOUSE
NC score	0.944627 (rank : 62)	θ value	2.59387e-31 (rank : 113)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	817
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST32B_MOUSE
NC score	0.944596 (rank : 63)	θ value	2.77131e-33 (rank : 103)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
NC score	0.944486 (rank : 64)	θ value	2.59387e-31 (rank : 112)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

PKN1_MOUSE
NC score	0.944263 (rank : 65)	θ value	7.01481e-53 (rank : 52)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

KPCL_MOUSE
NC score	0.943886 (rank : 66)	θ value	4.85792e-54 (rank : 42)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_MOUSE
NC score	0.943566 (rank : 67)	θ value	2.32979e-56 (rank : 32)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	834
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LATS1_HUMAN
NC score	0.943497 (rank : 68)	θ value	3.35642e-63 (rank : 7)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1057	Shared Neighborhood Hits	904
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

KPCL_HUMAN
NC score	0.943494 (rank : 69)	θ value	1.08223e-53 (rank : 46)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	820
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_HUMAN
NC score	0.943121 (rank : 70)	θ value	1.78386e-56 (rank : 31)
Query Neighborhood Hits	1804	Target Neighborhood Hits	897	Shared Neighborhood Hits	837
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LATS1_MOUSE
NC score	0.942495 (rank : 71)	θ value	5.35859e-61 (rank : 9)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1027	Shared Neighborhood Hits	883
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

MASTL_HUMAN
NC score	0.941516 (rank : 72)	θ value	1.24399e-33 (rank : 101)
Query Neighborhood Hits	1804	Target Neighborhood Hits	894	Shared Neighborhood Hits	844
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

KPCE_MOUSE
NC score	0.941510 (rank : 73)	θ value	4.25575e-50 (rank : 60)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	831
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_HUMAN
NC score	0.941507 (rank : 74)	θ value	9.48078e-50 (rank : 62)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	829
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MASTL_MOUSE
NC score	0.940719 (rank : 75)	θ value	5.584e-34 (rank : 99)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

LATS2_HUMAN
NC score	0.940499 (rank : 76)	θ value	6.13105e-57 (rank : 29)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	839
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
NC score	0.940261 (rank : 77)	θ value	4.39379e-55 (rank : 38)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	843
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

KPCD_MOUSE
NC score	0.939944 (rank : 78)	θ value	1.04822e-48 (rank : 69)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	830
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_HUMAN
NC score	0.939672 (rank : 79)	θ value	1.788e-48 (rank : 70)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	832
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

RK_HUMAN
NC score	0.939272 (rank : 80)	θ value	9.52487e-34 (rank : 100)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	820
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP1A_HUMAN
NC score	0.938732 (rank : 81)	θ value	6.14528e-49 (rank : 64)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	838
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

GRK7_HUMAN
NC score	0.938467 (rank : 82)	θ value	3.4976e-36 (rank : 94)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	814
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KGP1B_MOUSE
NC score	0.938358 (rank : 83)	θ value	3.60269e-49 (rank : 63)
Query Neighborhood Hits	1804	Target Neighborhood Hits	922	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.938256 (rank : 84)	θ value	6.14528e-49 (rank : 65)
Query Neighborhood Hits	1804	Target Neighborhood Hits	921	Shared Neighborhood Hits	839
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
NC score	0.937569 (rank : 85)	θ value	4.122e-45 (rank : 87)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	850
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

RK_MOUSE
NC score	0.937480 (rank : 86)	θ value	1.0531e-32 (rank : 106)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	818
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP2_MOUSE
NC score	0.937277 (rank : 87)	θ value	2.67181e-44 (rank : 88)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1029	Shared Neighborhood Hits	847
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ARBK2_HUMAN
NC score	0.936949 (rank : 88)	θ value	8.91499e-32 (rank : 110)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	818
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARBK1_HUMAN
NC score	0.936271 (rank : 89)	θ value	7.54701e-31 (rank : 115)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	819
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
NC score	0.936188 (rank : 90)	θ value	5.77852e-31 (rank : 114)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	820
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

GRK6_HUMAN
NC score	0.934823 (rank : 91)	θ value	3.27365e-34 (rank : 97)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	814
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
NC score	0.934585 (rank : 92)	θ value	2.96089e-35 (rank : 95)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

AURKB_MOUSE
NC score	0.934158 (rank : 93)	θ value	7.06379e-29 (rank : 131)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	839
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

GRK5_MOUSE
NC score	0.933987 (rank : 94)	θ value	8.06329e-33 (rank : 104)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	807
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_HUMAN
NC score	0.933931 (rank : 95)	θ value	1.0531e-32 (rank : 105)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	807
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

AURKC_MOUSE
NC score	0.933449 (rank : 96)	θ value	3.17079e-29 (rank : 129)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AURKC_HUMAN
NC score	0.933305 (rank : 97)	θ value	2.86786e-30 (rank : 121)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

GRK4_HUMAN
NC score	0.933210 (rank : 98)	θ value	5.22648e-32 (rank : 108)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	807
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

AURKB_HUMAN
NC score	0.932984 (rank : 99)	θ value	2.19584e-30 (rank : 118)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

STK6_MOUSE
NC score	0.932813 (rank : 100)	θ value	1.08979e-29 (rank : 123)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	850
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STK6_HUMAN
NC score	0.932199 (rank : 101)	θ value	1.98606e-31 (rank : 111)
Query Neighborhood Hits	1804	Target Neighborhood Hits	916	Shared Neighborhood Hits	861
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

KKCC1_MOUSE
NC score	0.930233 (rank : 102)	θ value	4.28545e-26 (rank : 172)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	840
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

GRK4_MOUSE
NC score	0.930162 (rank : 103)	θ value	2.19584e-30 (rank : 119)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	801
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

DCAK3_HUMAN
NC score	0.929620 (rank : 104)	θ value	2.34606e-32 (rank : 107)
Query Neighborhood Hits	1804	Target Neighborhood Hits	888	Shared Neighborhood Hits	846
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

F5006_MOUSE
NC score	0.929458 (rank : 105)	θ value	1.86321e-21 (rank : 243)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	792
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KKCC1_HUMAN
NC score	0.929127 (rank : 106)	θ value	1.80048e-24 (rank : 198)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	838
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

DCAK3_MOUSE
NC score	0.928456 (rank : 107)	θ value	1.6813e-30 (rank : 117)
Query Neighborhood Hits	1804	Target Neighborhood Hits	922	Shared Neighborhood Hits	864
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KPSH2_HUMAN
NC score	0.927461 (rank : 108)	θ value	3.28125e-26 (rank : 171)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	811
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

PLK4_HUMAN
NC score	0.927241 (rank : 109)	θ value	2.42779e-29 (rank : 128)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
NC score	0.927110 (rank : 110)	θ value	3.74554e-30 (rank : 122)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	839
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KKCC2_MOUSE
NC score	0.926897 (rank : 111)	θ value	2.68423e-28 (rank : 138)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	833
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KCC1D_MOUSE
NC score	0.926783 (rank : 112)	θ value	5.97985e-28 (rank : 147)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.926761 (rank : 113)	θ value	5.97985e-28 (rank : 146)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KKCC2_HUMAN
NC score	0.926637 (rank : 114)	θ value	2.68423e-28 (rank : 137)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	832
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

F5006_HUMAN
NC score	0.925923 (rank : 115)	θ value	1.5773e-20 (rank : 265)
Query Neighborhood Hits	1804	Target Neighborhood Hits	794	Shared Neighborhood Hits	787
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KCC1B_HUMAN
NC score	0.925687 (rank : 116)	θ value	2.42779e-29 (rank : 125)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	827
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
NC score	0.925621 (rank : 117)	θ value	1.85889e-29 (rank : 124)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	827
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1G_MOUSE
NC score	0.925447 (rank : 118)	θ value	2.05525e-28 (rank : 134)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	834
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.925216 (rank : 119)	θ value	1.57365e-28 (rank : 133)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	830
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

BRSK1_HUMAN
NC score	0.925175 (rank : 120)	θ value	9.8567e-31 (rank : 116)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	869
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

KCC1A_MOUSE
NC score	0.924922 (rank : 121)	θ value	1.47289e-26 (rank : 164)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	830
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
NC score	0.924862 (rank : 122)	θ value	1.12775e-26 (rank : 162)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	830
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPSH1_MOUSE
NC score	0.924451 (rank : 123)	θ value	2.68423e-28 (rank : 139)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_HUMAN
NC score	0.924410 (rank : 124)	θ value	1.02001e-27 (rank : 149)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	825
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

CHK2_HUMAN
NC score	0.924294 (rank : 125)	θ value	1.62847e-25 (rank : 182)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	827
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

PLK1_HUMAN
NC score	0.923917 (rank : 126)	θ value	1.5242e-23 (rank : 215)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	828
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
NC score	0.923851 (rank : 127)	θ value	6.84181e-24 (rank : 212)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

TSSK4_MOUSE
NC score	0.923435 (rank : 128)	θ value	4.57862e-28 (rank : 145)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

CHK2_MOUSE
NC score	0.923266 (rank : 129)	θ value	3.28125e-26 (rank : 170)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.923003 (rank : 130)	θ value	1.73987e-27 (rank : 151)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	848
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

ULK3_MOUSE
NC score	0.922766 (rank : 131)	θ value	1.62847e-25 (rank : 183)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK33_HUMAN
NC score	0.922653 (rank : 132)	θ value	9.54697e-26 (rank : 179)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	838
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

BRSK2_HUMAN
NC score	0.922414 (rank : 133)	θ value	5.40856e-29 (rank : 130)
Query Neighborhood Hits	1804	Target Neighborhood Hits	897	Shared Neighborhood Hits	853
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

KCC4_MOUSE
NC score	0.921954 (rank : 134)	θ value	5.06226e-27 (rank : 159)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	835
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

NUAK2_HUMAN
NC score	0.921879 (rank : 135)	θ value	4.57862e-28 (rank : 144)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

KCC4_HUMAN
NC score	0.921220 (rank : 136)	θ value	7.30988e-26 (rank : 175)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

SNRK_HUMAN
NC score	0.921068 (rank : 137)	θ value	1.12775e-26 (rank : 163)
Query Neighborhood Hits	1804	Target Neighborhood Hits	855	Shared Neighborhood Hits	820
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

HUNK_HUMAN
NC score	0.920778 (rank : 138)	θ value	3.17815e-21 (rank : 249)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	848
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

NUAK1_MOUSE
NC score	0.920690 (rank : 139)	θ value	2.42779e-29 (rank : 127)
Query Neighborhood Hits	1804	Target Neighborhood Hits	881	Shared Neighborhood Hits	849
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

TSSK4_HUMAN
NC score	0.920364 (rank : 140)	θ value	1.37858e-24 (rank : 196)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

NUAK1_HUMAN
NC score	0.920352 (rank : 141)	θ value	2.42779e-29 (rank : 126)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

ST17A_HUMAN
NC score	0.920326 (rank : 142)	θ value	1.5242e-23 (rank : 216)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

HUNK_MOUSE
NC score	0.920204 (rank : 143)	θ value	1.2077e-20 (rank : 260)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

AAPK2_HUMAN
NC score	0.920197 (rank : 144)	θ value	2.51237e-26 (rank : 168)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	830
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

PHKG2_MOUSE
NC score	0.920012 (rank : 145)	θ value	1.29031e-22 (rank : 228)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	829
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

SBK1_MOUSE
NC score	0.919938 (rank : 146)	θ value	2.5182e-18 (rank : 305)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	808
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MELK_MOUSE
NC score	0.919803 (rank : 147)	θ value	1.6852e-22 (rank : 230)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

SNRK_MOUSE
NC score	0.919779 (rank : 148)	θ value	3.87602e-27 (rank : 157)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	816
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PLK2_HUMAN
NC score	0.919765 (rank : 149)	θ value	1.99067e-23 (rank : 220)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	834
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

AAPK1_MOUSE
NC score	0.919735 (rank : 150)	θ value	2.96777e-27 (rank : 154)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	830
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

ULK3_HUMAN
NC score	0.919643 (rank : 151)	θ value	1.5773e-20 (rank : 268)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KPCA_MOUSE
NC score	0.919502 (rank : 152)	θ value	2.3352e-48 (rank : 72)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1067	Shared Neighborhood Hits	830
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MELK_HUMAN
NC score	0.919463 (rank : 153)	θ value	8.36355e-22 (rank : 239)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	833
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

PHKG2_HUMAN
NC score	0.919284 (rank : 154)	θ value	6.40375e-22 (rank : 238)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	828
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PLK2_MOUSE
NC score	0.919218 (rank : 155)	θ value	1.99067e-23 (rank : 221)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

AAPK1_HUMAN
NC score	0.919169 (rank : 156)	θ value	5.06226e-27 (rank : 158)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	830
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KPCA_HUMAN
NC score	0.919167 (rank : 157)	θ value	6.14528e-49 (rank : 66)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1070	Shared Neighborhood Hits	834
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PLK3_HUMAN
NC score	0.918718 (rank : 158)	θ value	1.99067e-23 (rank : 222)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	838
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

SBK1_HUMAN
NC score	0.918438 (rank : 159)	θ value	1.24977e-17 (rank : 323)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	810
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PLK3_MOUSE
NC score	0.918240 (rank : 160)	θ value	1.99067e-23 (rank : 223)
Query Neighborhood Hits	1804	Target Neighborhood Hits	863	Shared Neighborhood Hits	836
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

MARK2_HUMAN
NC score	0.918071 (rank : 161)	θ value	1.2049e-28 (rank : 132)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	921
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PHKG1_MOUSE
NC score	0.917989 (rank : 162)	θ value	2.06002e-20 (rank : 271)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	828
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

STK36_HUMAN
NC score	0.917937 (rank : 163)	θ value	5.22648e-32 (rank : 109)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	847
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CHK1_MOUSE
NC score	0.917908 (rank : 164)	θ value	1.2077e-20 (rank : 259)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	834
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_HUMAN
NC score	0.917829 (rank : 165)	θ value	1.2077e-20 (rank : 258)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	831
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

ULK1_MOUSE
NC score	0.917718 (rank : 166)	θ value	7.80994e-28 (rank : 148)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1214	Shared Neighborhood Hits	998
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

MARK2_MOUSE
NC score	0.917395 (rank : 167)	θ value	2.05525e-28 (rank : 135)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1018	Shared Neighborhood Hits	913
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

KPCB_HUMAN
NC score	0.917383 (rank : 168)	θ value	4.25575e-50 (rank : 59)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1121	Shared Neighborhood Hits	832
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PHKG1_HUMAN
NC score	0.917030 (rank : 169)	θ value	1.2077e-20 (rank : 263)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	829
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

DAPK2_MOUSE
NC score	0.916969 (rank : 170)	θ value	8.08199e-25 (rank : 190)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

NIM1_MOUSE
NC score	0.916940 (rank : 171)	θ value	1.37858e-24 (rank : 193)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KPCB_MOUSE
NC score	0.916249 (rank : 172)	θ value	3.98324e-48 (rank : 75)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1117	Shared Neighborhood Hits	832
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MARK4_HUMAN
NC score	0.916199 (rank : 173)	θ value	1.47289e-26 (rank : 165)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	852
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

ULK2_MOUSE
NC score	0.916171 (rank : 174)	θ value	2.05525e-28 (rank : 136)
Query Neighborhood Hits	1804	Target Neighborhood Hits	943	Shared Neighborhood Hits	888
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KCC2G_HUMAN
NC score	0.916162 (rank : 175)	θ value	3.87602e-27 (rank : 155)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	825
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
NC score	0.916127 (rank : 176)	θ value	3.87602e-27 (rank : 156)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

ULK1_HUMAN
NC score	0.916051 (rank : 177)	θ value	8.63488e-27 (rank : 161)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1121	Shared Neighborhood Hits	956
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

MARK4_MOUSE
NC score	0.916026 (rank : 178)	θ value	1.47289e-26 (rank : 166)
Query Neighborhood Hits	1804	Target Neighborhood Hits	898	Shared Neighborhood Hits	853
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

STK36_MOUSE
NC score	0.915767 (rank : 179)	θ value	2.19584e-30 (rank : 120)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	841
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ULK4_MOUSE
NC score	0.915684 (rank : 180)	θ value	4.58923e-20 (rank : 273)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	770
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

NIM1_HUMAN
NC score	0.915673 (rank : 181)	θ value	2.35151e-24 (rank : 201)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	828
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KCC2B_HUMAN
NC score	0.915666 (rank : 182)	θ value	5.23862e-24 (rank : 210)
Query Neighborhood Hits	1804	Target Neighborhood Hits	866	Shared Neighborhood Hits	835
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

ST17B_MOUSE
NC score	0.915559 (rank : 183)	θ value	1.2077e-20 (rank : 264)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC2A_HUMAN
NC score	0.915547 (rank : 184)	θ value	8.63488e-27 (rank : 160)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2D_HUMAN
NC score	0.915528 (rank : 185)	θ value	9.54697e-26 (rank : 178)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	817
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

MARK3_MOUSE
NC score	0.915426 (rank : 186)	θ value	3.50572e-28 (rank : 141)
Query Neighborhood Hits	1804	Target Neighborhood Hits	919	Shared Neighborhood Hits	868
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

ULK2_HUMAN
NC score	0.915385 (rank : 187)	θ value	2.68423e-28 (rank : 140)
Query Neighborhood Hits	1804	Target Neighborhood Hits	979	Shared Neighborhood Hits	892
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

DAPK2_HUMAN
NC score	0.915281 (rank : 188)	θ value	4.01107e-24 (rank : 204)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST17B_HUMAN
NC score	0.915067 (rank : 189)	θ value	1.74391e-19 (rank : 285)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KPCG_MOUSE
NC score	0.914835 (rank : 190)	θ value	6.35935e-46 (rank : 84)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	834
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.914795 (rank : 191)	θ value	2.18568e-46 (rank : 82)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1126	Shared Neighborhood Hits	836
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

SN1L1_HUMAN
NC score	0.914724 (rank : 192)	θ value	1.47289e-26 (rank : 167)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	854
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

KCC2A_MOUSE
NC score	0.914690 (rank : 193)	θ value	5.59698e-26 (rank : 173)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	815
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

MARK1_MOUSE
NC score	0.914530 (rank : 194)	θ value	4.57862e-28 (rank : 143)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	847
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

STK11_HUMAN
NC score	0.914507 (rank : 195)	θ value	7.82807e-20 (rank : 278)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	825
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

MARK1_HUMAN
NC score	0.914356 (rank : 196)	θ value	4.57862e-28 (rank : 142)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	847
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

NEK3_MOUSE
NC score	0.914328 (rank : 197)	θ value	2.87452e-22 (rank : 236)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	832
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MYLK2_HUMAN
NC score	0.913463 (rank : 198)	θ value	1.86321e-21 (rank : 245)
Query Neighborhood Hits	1804	Target Neighborhood Hits	920	Shared Neighborhood Hits	867
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEK3_HUMAN
NC score	0.913343 (rank : 199)	θ value	4.01107e-24 (rank : 206)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	835
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

KCC2B_MOUSE
NC score	0.913208 (rank : 200)	θ value	5.23862e-24 (rank : 211)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

DAPK3_MOUSE
NC score	0.913006 (rank : 201)	θ value	2.35151e-24 (rank : 200)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	818
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

SN1L1_MOUSE
NC score	0.912818 (rank : 202)	θ value	2.51237e-26 (rank : 169)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	856
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_MOUSE
NC score	0.911835 (rank : 203)	θ value	1.02001e-27 (rank : 150)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	860
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

KPCD2_HUMAN
NC score	0.911809 (rank : 204)	θ value	7.30988e-26 (rank : 176)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	832
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

SN1L2_HUMAN
NC score	0.911792 (rank : 205)	θ value	1.73987e-27 (rank : 152)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	881
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

K0999_MOUSE
NC score	0.911535 (rank : 206)	θ value	6.18819e-25 (rank : 189)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	868
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

DAPK3_HUMAN
NC score	0.911405 (rank : 207)	θ value	8.08199e-25 (rank : 191)
Query Neighborhood Hits	1804	Target Neighborhood Hits	945	Shared Neighborhood Hits	827
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KPCD1_HUMAN
NC score	0.911367 (rank : 208)	θ value	1.24688e-25 (rank : 180)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	830
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

TSSK2_HUMAN
NC score	0.911323 (rank : 209)	θ value	2.69047e-20 (rank : 272)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	818
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

KPCD1_MOUSE
NC score	0.911306 (rank : 210)	θ value	2.77775e-25 (rank : 186)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	829
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

K0999_HUMAN
NC score	0.911272 (rank : 211)	θ value	8.08199e-25 (rank : 192)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MAPK2_HUMAN
NC score	0.911251 (rank : 212)	θ value	1.24977e-17 (rank : 322)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PASK_MOUSE
NC score	0.911011 (rank : 213)	θ value	4.74913e-17 (rank : 333)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	826
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

MAPK3_MOUSE
NC score	0.910712 (rank : 214)	θ value	2.43343e-21 (rank : 247)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	803
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MRCKG_HUMAN
NC score	0.910615 (rank : 215)	θ value	7.49467e-55 (rank : 39)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1519	Shared Neighborhood Hits	893
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MAPK2_MOUSE
NC score	0.910464 (rank : 216)	θ value	2.5182e-18 (rank : 304)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MARK3_HUMAN
NC score	0.910431 (rank : 217)	θ value	4.01107e-24 (rank : 205)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	851
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

DCAK2_MOUSE
NC score	0.909411 (rank : 218)	θ value	7.30988e-26 (rank : 174)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

MAPK3_HUMAN
NC score	0.909249 (rank : 219)	θ value	1.86321e-21 (rank : 244)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	793
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

DCAK2_HUMAN
NC score	0.909150 (rank : 220)	θ value	9.54697e-26 (rank : 177)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	831
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

TSSK1_HUMAN
NC score	0.908995 (rank : 221)	θ value	3.17815e-21 (rank : 251)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KPCD3_HUMAN
NC score	0.908944 (rank : 222)	θ value	1.99067e-23 (rank : 219)
Query Neighborhood Hits	1804	Target Neighborhood Hits	895	Shared Neighborhood Hits	828
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

MRCKG_MOUSE
NC score	0.908931 (rank : 223)	θ value	2.18062e-54 (rank : 40)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1466	Shared Neighborhood Hits	871
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KPCD3_MOUSE
NC score	0.908677 (rank : 224)	θ value	3.39556e-23 (rank : 224)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	826
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

DCAK1_MOUSE
NC score	0.908634 (rank : 225)	θ value	6.18819e-25 (rank : 188)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	837
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

TSSK2_MOUSE
NC score	0.908599 (rank : 226)	θ value	1.47631e-18 (rank : 300)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	808
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

DCAK1_HUMAN
NC score	0.908502 (rank : 227)	θ value	6.18819e-25 (rank : 187)
Query Neighborhood Hits	1804	Target Neighborhood Hits	877	Shared Neighborhood Hits	839
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MKNK2_HUMAN
NC score	0.908398 (rank : 228)	θ value	8.95645e-16 (rank : 362)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK1_MOUSE
NC score	0.908311 (rank : 229)	θ value	2.27762e-19 (rank : 286)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	799
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

TSSK1_MOUSE
NC score	0.908164 (rank : 230)	θ value	1.13037e-18 (rank : 298)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MKNK2_MOUSE
NC score	0.908084 (rank : 231)	θ value	5.25075e-16 (rank : 355)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	809
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

TSSK6_MOUSE
NC score	0.906193 (rank : 232)	θ value	2.35696e-16 (rank : 346)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	816
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_HUMAN
NC score	0.906131 (rank : 233)	θ value	8.10077e-17 (rank : 336)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PAK6_HUMAN
NC score	0.905409 (rank : 234)	θ value	2.35151e-24 (rank : 202)
Query Neighborhood Hits	1804	Target Neighborhood Hits	915	Shared Neighborhood Hits	870
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK4_HUMAN
NC score	0.904786 (rank : 235)	θ value	9.24701e-21 (rank : 257)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	873
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

TSSK3_HUMAN
NC score	0.904483 (rank : 236)	θ value	1.5242e-23 (rank : 217)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	799
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

PAK4_MOUSE
NC score	0.904172 (rank : 237)	θ value	1.5773e-20 (rank : 267)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1098	Shared Neighborhood Hits	955
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK2_MOUSE
NC score	0.903846 (rank : 238)	θ value	5.60996e-18 (rank : 317)
Query Neighborhood Hits	1804	Target Neighborhood Hits	876	Shared Neighborhood Hits	820
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PAK7_HUMAN
NC score	0.903712 (rank : 239)	θ value	1.80048e-24 (rank : 199)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	841
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

TSSK3_MOUSE
NC score	0.903689 (rank : 240)	θ value	1.09232e-21 (rank : 241)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	799
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

PAK7_MOUSE
NC score	0.903638 (rank : 241)	θ value	4.01107e-24 (rank : 207)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	845
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

NEK2_HUMAN
NC score	0.903355 (rank : 242)	θ value	1.74391e-19 (rank : 284)
Query Neighborhood Hits	1804	Target Neighborhood Hits	908	Shared Neighborhood Hits	818
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

M3K14_HUMAN
NC score	0.902517 (rank : 243)	θ value	1.24977e-17 (rank : 321)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

NEK1_HUMAN
NC score	0.901696 (rank : 244)	θ value	1.86321e-21 (rank : 246)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1129	Shared Neighborhood Hits	873
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

PASK_HUMAN
NC score	0.901479 (rank : 245)	θ value	3.76295e-14 (rank : 417)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	819
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PAK2_MOUSE
NC score	0.901194 (rank : 246)	θ value	8.93572e-24 (rank : 213)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	841
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

NEK1_MOUSE
NC score	0.901167 (rank : 247)	θ value	1.42661e-21 (rank : 242)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1311	Shared Neighborhood Hits	907
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

PAK2_HUMAN
NC score	0.901044 (rank : 248)	θ value	7.56453e-23 (rank : 227)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	843
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

NEK4_MOUSE
NC score	0.900997 (rank : 249)	θ value	3.17815e-21 (rank : 250)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

PIM2_MOUSE
NC score	0.900134 (rank : 250)	θ value	3.40345e-15 (rank : 384)
Query Neighborhood Hits	1804	Target Neighborhood Hits	809	Shared Neighborhood Hits	798
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

NEK4_HUMAN
NC score	0.899984 (rank : 251)	θ value	1.6852e-22 (rank : 231)
Query Neighborhood Hits	1804	Target Neighborhood Hits	883	Shared Neighborhood Hits	837
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PAK3_MOUSE
NC score	0.899538 (rank : 252)	θ value	2.20094e-22 (rank : 233)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.899533 (rank : 253)	θ value	2.20094e-22 (rank : 232)
Query Neighborhood Hits	1804	Target Neighborhood Hits	887	Shared Neighborhood Hits	854
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_HUMAN
NC score	0.899452 (rank : 254)	θ value	5.79196e-23 (rank : 225)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	848
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
NC score	0.899099 (rank : 255)	θ value	5.79196e-23 (rank : 226)
Query Neighborhood Hits	1804	Target Neighborhood Hits	878	Shared Neighborhood Hits	851
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

M3K3_MOUSE
NC score	0.898625 (rank : 256)	θ value	1.33526e-19 (rank : 283)
Query Neighborhood Hits	1804	Target Neighborhood Hits	876	Shared Neighborhood Hits	842
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK6_HUMAN
NC score	0.898523 (rank : 257)	θ value	7.0802e-21 (rank : 254)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	836
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

M3K3_HUMAN
NC score	0.898509 (rank : 258)	θ value	5.99374e-20 (rank : 275)
Query Neighborhood Hits	1804	Target Neighborhood Hits	885	Shared Neighborhood Hits	844
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK6_MOUSE
NC score	0.898266 (rank : 259)	θ value	1.2077e-20 (rank : 261)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	837
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PIM2_HUMAN
NC score	0.897984 (rank : 260)	θ value	1.29331e-14 (rank : 401)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	800
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

M3K2_HUMAN
NC score	0.897946 (rank : 261)	θ value	4.29542e-18 (rank : 313)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
NC score	0.897814 (rank : 262)	θ value	7.32683e-18 (rank : 319)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	827
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K1_MOUSE
NC score	0.896483 (rank : 263)	θ value	3.18553e-13 (rank : 454)
Query Neighborhood Hits	1804	Target Neighborhood Hits	952	Shared Neighborhood Hits	864
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

MAPK5_MOUSE
NC score	0.896275 (rank : 264)	θ value	6.85773e-16 (rank : 356)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

NEK7_MOUSE
NC score	0.896072 (rank : 265)	θ value	5.42112e-21 (rank : 253)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	836
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MP2K1_HUMAN
NC score	0.895976 (rank : 266)	θ value	2.87452e-22 (rank : 234)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
NC score	0.895910 (rank : 267)	θ value	1.5773e-20 (rank : 266)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

NEK7_HUMAN
NC score	0.895875 (rank : 268)	θ value	2.43343e-21 (rank : 248)
Query Neighborhood Hits	1804	Target Neighborhood Hits	846	Shared Neighborhood Hits	835
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MP2K1_MOUSE
NC score	0.895832 (rank : 269)	θ value	1.09232e-21 (rank : 240)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

M3K14_MOUSE
NC score	0.895531 (rank : 270)	θ value	3.63628e-17 (rank : 330)
Query Neighborhood Hits	1804	Target Neighborhood Hits	889	Shared Neighborhood Hits	828
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K4_HUMAN
NC score	0.895478 (rank : 271)	θ value	8.10077e-17 (rank : 335)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

E2AK2_MOUSE
NC score	0.895233 (rank : 272)	θ value	7.82807e-20 (rank : 277)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	832
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

M3K4_MOUSE
NC score	0.894836 (rank : 273)	θ value	1.38178e-16 (rank : 341)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	849
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

NEK11_HUMAN
NC score	0.894320 (rank : 274)	θ value	9.24701e-21 (rank : 256)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1043	Shared Neighborhood Hits	861
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

MAPK5_HUMAN
NC score	0.894256 (rank : 275)	θ value	1.52774e-15 (rank : 369)
Query Neighborhood Hits	1804	Target Neighborhood Hits	795	Shared Neighborhood Hits	780
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

CAMKV_MOUSE
NC score	0.894236 (rank : 276)	θ value	1.33526e-19 (rank : 282)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	801
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_HUMAN
NC score	0.893964 (rank : 277)	θ value	1.33526e-19 (rank : 281)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1084	Shared Neighborhood Hits	905
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

NEK11_MOUSE
NC score	0.893829 (rank : 278)	θ value	3.28887e-18 (rank : 310)
Query Neighborhood Hits	1804	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

MP2K2_MOUSE
NC score	0.893794 (rank : 279)	θ value	9.24701e-21 (rank : 255)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M3K6_HUMAN
NC score	0.893369 (rank : 280)	θ value	3.63628e-17 (rank : 331)
Query Neighborhood Hits	1804	Target Neighborhood Hits	889	Shared Neighborhood Hits	851
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

PIM3_HUMAN
NC score	0.892668 (rank : 281)	θ value	1.86753e-13 (rank : 447)
Query Neighborhood Hits	1804	Target Neighborhood Hits	789	Shared Neighborhood Hits	784
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
NC score	0.891766 (rank : 282)	θ value	2.43908e-13 (rank : 452)
Query Neighborhood Hits	1804	Target Neighborhood Hits	783	Shared Neighborhood Hits	778
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM1_MOUSE
NC score	0.891164 (rank : 283)	θ value	3.40345e-15 (rank : 383)
Query Neighborhood Hits	1804	Target Neighborhood Hits	787	Shared Neighborhood Hits	781
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

M3K5_MOUSE
NC score	0.890439 (rank : 284)	θ value	2.13179e-17 (rank : 327)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.890228 (rank : 285)	θ value	2.13179e-17 (rank : 326)
Query Neighborhood Hits	1804	Target Neighborhood Hits	868	Shared Neighborhood Hits	830
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

NEK8_MOUSE
NC score	0.889113 (rank : 286)	θ value	2.97466e-19 (rank : 288)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	831
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PIM1_HUMAN
NC score	0.889041 (rank : 287)	θ value	2.88119e-14 (rank : 411)
Query Neighborhood Hits	1804	Target Neighborhood Hits	797	Shared Neighborhood Hits	791
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

NEK8_HUMAN
NC score	0.888985 (rank : 288)	θ value	3.88503e-19 (rank : 290)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

PMYT1_MOUSE
NC score	0.888869 (rank : 289)	θ value	5.08577e-11 (rank : 517)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	867
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

IKKA_MOUSE
NC score	0.888541 (rank : 290)	θ value	4.59992e-12 (rank : 483)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	829
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

STK40_HUMAN
NC score	0.888471 (rank : 291)	θ value	3.63628e-17 (rank : 332)
Query Neighborhood Hits	1804	Target Neighborhood Hits	751	Shared Neighborhood Hits	740
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK3_HUMAN
NC score	0.888200 (rank : 292)	θ value	2.27234e-27 (rank : 153)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	838
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK40_MOUSE
NC score	0.888193 (rank : 293)	θ value	2.7842e-17 (rank : 328)
Query Neighborhood Hits	1804	Target Neighborhood Hits	751	Shared Neighborhood Hits	740
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

PDK1L_HUMAN
NC score	0.887840 (rank : 294)	θ value	2.28291e-11 (rank : 503)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

STK3_MOUSE
NC score	0.887580 (rank : 295)	θ value	1.24688e-25 (rank : 181)
Query Neighborhood Hits	1804	Target Neighborhood Hits	869	Shared Neighborhood Hits	838
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

PDK1L_MOUSE
NC score	0.887501 (rank : 296)	θ value	2.28291e-11 (rank : 504)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

M3K15_HUMAN
NC score	0.887200 (rank : 297)	θ value	1.13037e-18 (rank : 297)
Query Neighborhood Hits	1804	Target Neighborhood Hits	914	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

IKKA_HUMAN
NC score	0.886900 (rank : 298)	θ value	3.52202e-12 (rank : 482)
Query Neighborhood Hits	1804	Target Neighborhood Hits	863	Shared Neighborhood Hits	829
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MP2K7_HUMAN
NC score	0.885846 (rank : 299)	θ value	1.29331e-14 (rank : 400)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

STK4_HUMAN
NC score	0.885773 (rank : 300)	θ value	1.37858e-24 (rank : 195)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	834
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
NC score	0.885702 (rank : 301)	θ value	2.35151e-24 (rank : 203)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

TBK1_HUMAN
NC score	0.885419 (rank : 302)	θ value	6.41864e-14 (rank : 426)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
NC score	0.885338 (rank : 303)	θ value	1.42992e-13 (rank : 445)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	802
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

IKKB_HUMAN
NC score	0.885236 (rank : 304)	θ value	9.26847e-13 (rank : 466)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	841
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CDKL3_MOUSE
NC score	0.885065 (rank : 305)	θ value	2.97466e-19 (rank : 287)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

STK35_HUMAN
NC score	0.884750 (rank : 306)	θ value	5.8054e-15 (rank : 394)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	814
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

MP2K5_MOUSE
NC score	0.884063 (rank : 307)	θ value	1.38178e-16 (rank : 342)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

IKKB_MOUSE
NC score	0.883950 (rank : 308)	θ value	7.84624e-12 (rank : 491)
Query Neighborhood Hits	1804	Target Neighborhood Hits	984	Shared Neighborhood Hits	836
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CDKL5_HUMAN
NC score	0.883880 (rank : 309)	θ value	4.15078e-21 (rank : 252)
Query Neighborhood Hits	1804	Target Neighborhood Hits	967	Shared Neighborhood Hits	873
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

PMYT1_HUMAN
NC score	0.883593 (rank : 310)	θ value	2.98157e-11 (rank : 507)
Query Neighborhood Hits	1804	Target Neighborhood Hits	814	Shared Neighborhood Hits	804
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

CDKL3_HUMAN
NC score	0.883433 (rank : 311)	θ value	6.62687e-19 (rank : 292)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	829
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

IKKE_HUMAN
NC score	0.883123 (rank : 312)	θ value	3.40345e-15 (rank : 381)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	809
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

YSK4_HUMAN
NC score	0.882595 (rank : 313)	θ value	8.65492e-19 (rank : 295)
Query Neighborhood Hits	1804	Target Neighborhood Hits	921	Shared Neighborhood Hits	845
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

STK24_HUMAN
NC score	0.881991 (rank : 314)	θ value	3.88503e-19 (rank : 291)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

OXSR1_MOUSE
NC score	0.881987 (rank : 315)	θ value	1.2077e-20 (rank : 262)
Query Neighborhood Hits	1804	Target Neighborhood Hits	865	Shared Neighborhood Hits	839
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_HUMAN
NC score	0.881672 (rank : 316)	θ value	2.06002e-20 (rank : 270)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_MOUSE
NC score	0.881422 (rank : 317)	θ value	2.5182e-18 (rank : 308)
Query Neighborhood Hits	1804	Target Neighborhood Hits	915	Shared Neighborhood Hits	854
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK39_HUMAN
NC score	0.881219 (rank : 318)	θ value	2.5182e-18 (rank : 307)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	844
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

M4K3_HUMAN
NC score	0.881150 (rank : 319)	θ value	1.6852e-22 (rank : 229)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

STK25_HUMAN
NC score	0.881118 (rank : 320)	θ value	2.5182e-18 (rank : 306)
Query Neighborhood Hits	1804	Target Neighborhood Hits	853	Shared Neighborhood Hits	834
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MST4_MOUSE
NC score	0.880950 (rank : 321)	θ value	1.63225e-17 (rank : 325)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.880947 (rank : 322)	θ value	1.63225e-17 (rank : 324)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	834
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK24_MOUSE
NC score	0.880837 (rank : 323)	θ value	3.28887e-18 (rank : 312)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	837
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_MOUSE
NC score	0.880508 (rank : 324)	θ value	4.29542e-18 (rank : 316)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MP2K3_MOUSE
NC score	0.879958 (rank : 325)	θ value	1.47631e-18 (rank : 299)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

NEK9_MOUSE
NC score	0.879421 (rank : 326)	θ value	3.76295e-14 (rank : 416)
Query Neighborhood Hits	1804	Target Neighborhood Hits	890	Shared Neighborhood Hits	836
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

TTK_HUMAN
NC score	0.879396 (rank : 327)	θ value	7.84624e-12 (rank : 493)
Query Neighborhood Hits	1804	Target Neighborhood Hits	816	Shared Neighborhood Hits	780
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

NEK9_HUMAN
NC score	0.878351 (rank : 328)	θ value	3.76295e-14 (rank : 415)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	842
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MP2K3_HUMAN
NC score	0.877984 (rank : 329)	θ value	4.29542e-18 (rank : 314)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TTK_MOUSE
NC score	0.877969 (rank : 330)	θ value	9.26847e-13 (rank : 469)
Query Neighborhood Hits	1804	Target Neighborhood Hits	803	Shared Neighborhood Hits	764
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

MP2K5_HUMAN
NC score	0.877932 (rank : 331)	θ value	1.99529e-15 (rank : 375)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

E2AK2_HUMAN
NC score	0.877115 (rank : 332)	θ value	3.40345e-15 (rank : 380)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	823
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

M3K8_MOUSE
NC score	0.875776 (rank : 333)	θ value	2.20605e-14 (rank : 407)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	798
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

IKKE_MOUSE
NC score	0.875634 (rank : 334)	θ value	2.0648e-12 (rank : 477)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	811
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MP2K4_HUMAN
NC score	0.875326 (rank : 335)	θ value	5.8054e-15 (rank : 391)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.875078 (rank : 336)	θ value	5.8054e-15 (rank : 392)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

M3K8_HUMAN
NC score	0.874987 (rank : 337)	θ value	2.88119e-14 (rank : 409)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M4K2_MOUSE
NC score	0.874765 (rank : 338)	θ value	1.058e-16 (rank : 338)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

TLK2_HUMAN
NC score	0.874486 (rank : 339)	θ value	1.52774e-15 (rank : 371)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1044	Shared Neighborhood Hits	812
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

M4K2_HUMAN
NC score	0.874474 (rank : 340)	θ value	1.058e-16 (rank : 337)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

TLK1_HUMAN
NC score	0.874206 (rank : 341)	θ value	2.88119e-14 (rank : 413)
Query Neighborhood Hits	1804	Target Neighborhood Hits	967	Shared Neighborhood Hits	786
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

CDKL2_MOUSE
NC score	0.874151 (rank : 342)	θ value	1.99529e-15 (rank : 373)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

TLK1_MOUSE
NC score	0.874135 (rank : 343)	θ value	2.88119e-14 (rank : 414)
Query Neighborhood Hits	1804	Target Neighborhood Hits	947	Shared Neighborhood Hits	789
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

CDKL2_HUMAN
NC score	0.872602 (rank : 344)	θ value	9.90251e-15 (rank : 398)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

TLK2_MOUSE
NC score	0.872482 (rank : 345)	θ value	1.52774e-15 (rank : 372)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	816
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

CSKP_MOUSE
NC score	0.871940 (rank : 346)	θ value	2.12685e-25 (rank : 185)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1027	Shared Neighborhood Hits	879
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

CDKL1_MOUSE
NC score	0.871467 (rank : 347)	θ value	1.38178e-16 (rank : 339)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	823
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL4_MOUSE
NC score	0.871258 (rank : 348)	θ value	9.56915e-18 (rank : 320)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL1_HUMAN
NC score	0.870860 (rank : 349)	θ value	3.63628e-17 (rank : 329)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CSKP_HUMAN
NC score	0.869588 (rank : 350)	θ value	2.12685e-25 (rank : 184)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1022	Shared Neighborhood Hits	877
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

M4K1_HUMAN
NC score	0.869232 (rank : 351)	θ value	2.43908e-13 (rank : 450)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K5_MOUSE
NC score	0.868685 (rank : 352)	θ value	3.28887e-18 (rank : 309)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

CDK3_MOUSE
NC score	0.868573 (rank : 353)	θ value	5.8054e-15 (rank : 390)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

M4K1_MOUSE
NC score	0.868428 (rank : 354)	θ value	8.38298e-14 (rank : 429)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	833
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MP2K6_MOUSE
NC score	0.868367 (rank : 355)	θ value	1.38178e-16 (rank : 343)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_HUMAN
NC score	0.868193 (rank : 356)	θ value	2.35696e-16 (rank : 345)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	821
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

M4K5_HUMAN
NC score	0.867161 (rank : 357)	θ value	2.5182e-18 (rank : 303)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	828
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MKNK1_HUMAN
NC score	0.866779 (rank : 358)	θ value	2.69671e-12 (rank : 480)
Query Neighborhood Hits	1804	Target Neighborhood Hits	701	Shared Neighborhood Hits	690
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

CDKL4_HUMAN
NC score	0.866713 (rank : 359)	θ value	4.02038e-16 (rank : 349)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	822
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDC2_HUMAN
NC score	0.864908 (rank : 360)	θ value	5.25075e-16 (rank : 352)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	829
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK7_MOUSE
NC score	0.864536 (rank : 361)	θ value	1.92812e-18 (rank : 302)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK2_HUMAN
NC score	0.864521 (rank : 362)	θ value	1.13037e-18 (rank : 296)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK7_HUMAN
NC score	0.864231 (rank : 363)	θ value	1.92812e-18 (rank : 301)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDC2_MOUSE
NC score	0.863801 (rank : 364)	θ value	2.60593e-15 (rank : 376)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

GSK3A_HUMAN
NC score	0.863729 (rank : 365)	θ value	2.60593e-15 (rank : 377)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

CDK3_HUMAN
NC score	0.863141 (rank : 366)	θ value	2.06002e-20 (rank : 269)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

GSK3B_HUMAN
NC score	0.861562 (rank : 367)	θ value	2.20605e-14 (rank : 404)
Query Neighborhood Hits	1804	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.861537 (rank : 368)	θ value	2.20605e-14 (rank : 405)
Query Neighborhood Hits	1804	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

STK16_HUMAN
NC score	0.861483 (rank : 369)	θ value	0.000121331 (rank : 798)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	818
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

PFTK1_MOUSE
NC score	0.861034 (rank : 370)	θ value	3.28887e-18 (rank : 311)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	819
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_HUMAN
NC score	0.860700 (rank : 371)	θ value	4.29542e-18 (rank : 315)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	819
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDK2_MOUSE
NC score	0.860657 (rank : 372)	θ value	5.25075e-16 (rank : 353)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	819
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

MK15_HUMAN
NC score	0.859174 (rank : 373)	θ value	7.58209e-15 (rank : 397)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1038	Shared Neighborhood Hits	932
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CDK6_MOUSE
NC score	0.858756 (rank : 374)	θ value	5.23862e-24 (rank : 208)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

ICK_MOUSE
NC score	0.858321 (rank : 375)	θ value	1.42992e-13 (rank : 439)
Query Neighborhood Hits	1804	Target Neighborhood Hits	860	Shared Neighborhood Hits	831
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

STK16_MOUSE
NC score	0.857856 (rank : 376)	θ value	3.19293e-05 (rank : 770)
Query Neighborhood Hits	1804	Target Neighborhood Hits	824	Shared Neighborhood Hits	814
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

CDK6_HUMAN
NC score	0.857761 (rank : 377)	θ value	1.99067e-23 (rank : 218)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

PCTK3_MOUSE
NC score	0.857501 (rank : 378)	θ value	3.07829e-16 (rank : 348)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	823
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

SLK_MOUSE
NC score	0.857404 (rank : 379)	θ value	1.02238e-19 (rank : 280)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1798	Shared Neighborhood Hits	938
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

ICK_HUMAN
NC score	0.857354 (rank : 380)	θ value	1.09485e-13 (rank : 435)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MAK_MOUSE
NC score	0.856659 (rank : 381)	θ value	6.41864e-14 (rank : 425)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	843
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

CCRK_HUMAN
NC score	0.856163 (rank : 382)	θ value	4.44505e-15 (rank : 386)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	826
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

NRK_HUMAN
NC score	0.855634 (rank : 383)	θ value	1.74796e-11 (rank : 501)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	852
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

MK15_MOUSE
NC score	0.855506 (rank : 384)	θ value	4.59992e-12 (rank : 485)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

PCTK1_MOUSE
NC score	0.855435 (rank : 385)	θ value	1.16975e-15 (rank : 364)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

SLK_HUMAN
NC score	0.855266 (rank : 386)	θ value	5.99374e-20 (rank : 276)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1775	Shared Neighborhood Hits	925
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

PCTK3_HUMAN
NC score	0.855095 (rank : 387)	θ value	6.85773e-16 (rank : 358)
Query Neighborhood Hits	1804	Target Neighborhood Hits	827	Shared Neighborhood Hits	815
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CCRK_MOUSE
NC score	0.854997 (rank : 388)	θ value	4.44505e-15 (rank : 387)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

PCTK1_HUMAN
NC score	0.854883 (rank : 389)	θ value	2.60593e-15 (rank : 378)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	821
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

MAK_HUMAN
NC score	0.854766 (rank : 390)	θ value	1.86753e-13 (rank : 446)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	833
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MRCKA_HUMAN
NC score	0.853052 (rank : 391)	θ value	7.75577e-52 (rank : 54)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1999	Shared Neighborhood Hits	920
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

E2AK4_HUMAN
NC score	0.852939 (rank : 392)	θ value	4.30538e-10 (rank : 537)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1012	Shared Neighborhood Hits	859
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

NRK_MOUSE
NC score	0.852794 (rank : 393)	θ value	8.11959e-09 (rank : 591)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	849
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

E2AK3_HUMAN
NC score	0.852248 (rank : 394)	θ value	6.21693e-09 (rank : 582)
Query Neighborhood Hits	1804	Target Neighborhood Hits	859	Shared Neighborhood Hits	832
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

CD2L7_HUMAN
NC score	0.852106 (rank : 395)	θ value	8.38298e-14 (rank : 428)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1275	Shared Neighborhood Hits	983
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

PCTK2_HUMAN
NC score	0.851053 (rank : 396)	θ value	6.85773e-16 (rank : 357)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	821
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
NC score	0.850926 (rank : 397)	θ value	1.16975e-15 (rank : 365)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

E2AK4_MOUSE
NC score	0.850601 (rank : 398)	θ value	1.9326e-10 (rank : 529)
Query Neighborhood Hits	1804	Target Neighborhood Hits	984	Shared Neighborhood Hits	854
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

MK12_MOUSE
NC score	0.850511 (rank : 399)	θ value	2.43908e-13 (rank : 451)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_HUMAN
NC score	0.849920 (rank : 400)	θ value	3.18553e-13 (rank : 455)
Query Neighborhood Hits	1804	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CD2L5_MOUSE
NC score	0.849686 (rank : 401)	θ value	7.09661e-13 (rank : 465)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1011	Shared Neighborhood Hits	889
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

E2AK3_MOUSE
NC score	0.849669 (rank : 402)	θ value	6.21693e-09 (rank : 583)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

TNIK_HUMAN
NC score	0.849652 (rank : 403)	θ value	4.91457e-14 (rank : 421)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1570	Shared Neighborhood Hits	953
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

ROCK2_HUMAN
NC score	0.849508 (rank : 404)	θ value	8.85319e-56 (rank : 36)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2073	Shared Neighborhood Hits	934
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MINK1_HUMAN
NC score	0.849368 (rank : 405)	θ value	8.38298e-14 (rank : 431)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1477	Shared Neighborhood Hits	944
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

CDK5_HUMAN
NC score	0.849357 (rank : 406)	θ value	3.18553e-13 (rank : 453)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.849207 (rank : 407)	θ value	4.16044e-13 (rank : 456)
Query Neighborhood Hits	1804	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

MINK1_MOUSE
NC score	0.849188 (rank : 408)	θ value	8.38298e-14 (rank : 432)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1451	Shared Neighborhood Hits	921
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK14_MOUSE
NC score	0.849170 (rank : 409)	θ value	5.43371e-13 (rank : 462)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	826
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CD2L5_HUMAN
NC score	0.848913 (rank : 410)	θ value	7.09661e-13 (rank : 464)
Query Neighborhood Hits	1804	Target Neighborhood Hits	987	Shared Neighborhood Hits	872
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

E2AK1_MOUSE
NC score	0.848526 (rank : 411)	θ value	1.17247e-07 (rank : 631)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MK07_MOUSE
NC score	0.848408 (rank : 412)	θ value	5.25075e-16 (rank : 354)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1054	Shared Neighborhood Hits	915
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK14_HUMAN
NC score	0.848279 (rank : 413)	θ value	9.26847e-13 (rank : 468)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	826
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK07_HUMAN
NC score	0.847863 (rank : 414)	θ value	1.99529e-15 (rank : 374)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1087	Shared Neighborhood Hits	942
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

WNK3_HUMAN
NC score	0.847692 (rank : 415)	θ value	4.44505e-15 (rank : 389)
Query Neighborhood Hits	1804	Target Neighborhood Hits	948	Shared Neighborhood Hits	802
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

MK13_MOUSE
NC score	0.846069 (rank : 416)	θ value	5.43371e-13 (rank : 461)
Query Neighborhood Hits	1804	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK09_HUMAN
NC score	0.845982 (rank : 417)	θ value	8.95645e-16 (rank : 361)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

ROCK1_HUMAN
NC score	0.845441 (rank : 418)	θ value	5.54529e-58 (rank : 21)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2000	Shared Neighborhood Hits	926
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

AL2S7_HUMAN
NC score	0.845419 (rank : 419)	θ value	8.38298e-14 (rank : 427)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	820
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

TAOK2_HUMAN
NC score	0.844763 (rank : 420)	θ value	5.8054e-15 (rank : 395)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1172	Shared Neighborhood Hits	868
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

RPKL1_MOUSE
NC score	0.844536 (rank : 421)	θ value	4.44505e-15 (rank : 388)
Query Neighborhood Hits	1804	Target Neighborhood Hits	704	Shared Neighborhood Hits	672
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

MK13_HUMAN
NC score	0.844479 (rank : 422)	θ value	5.43371e-13 (rank : 460)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	824
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

CDK4_MOUSE
NC score	0.843886 (rank : 423)	θ value	1.02238e-19 (rank : 279)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

DYRK2_HUMAN
NC score	0.843550 (rank : 424)	θ value	1.29331e-14 (rank : 399)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

CDK4_HUMAN
NC score	0.843429 (rank : 425)	θ value	5.99374e-20 (rank : 274)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	821
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

E2AK1_HUMAN
NC score	0.843390 (rank : 426)	θ value	1.06045e-08 (rank : 594)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

NLK_MOUSE
NC score	0.843188 (rank : 427)	θ value	4.02038e-16 (rank : 351)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MYLK_MOUSE
NC score	0.843181 (rank : 428)	θ value	2.87452e-22 (rank : 235)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1489	Shared Neighborhood Hits	989
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

NLK_HUMAN
NC score	0.843118 (rank : 429)	θ value	4.02038e-16 (rank : 350)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MK11_MOUSE
NC score	0.842991 (rank : 430)	θ value	2.69671e-12 (rank : 479)
Query Neighborhood Hits	1804	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

ROCK2_MOUSE
NC score	0.842893 (rank : 431)	θ value	1.61343e-57 (rank : 25)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2072	Shared Neighborhood Hits	936
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RPKL1_HUMAN
NC score	0.842770 (rank : 432)	θ value	3.40345e-15 (rank : 385)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	665
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

CSK21_MOUSE
NC score	0.842209 (rank : 433)	θ value	5.26297e-08 (rank : 615)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	766
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

STK10_HUMAN
NC score	0.842141 (rank : 434)	θ value	2.97466e-19 (rank : 289)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1921	Shared Neighborhood Hits	998
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

ERN1_HUMAN
NC score	0.841592 (rank : 435)	θ value	1.9326e-10 (rank : 530)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	811
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CSK21_HUMAN
NC score	0.841560 (rank : 436)	θ value	5.26297e-08 (rank : 614)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	766
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MK09_MOUSE
NC score	0.840945 (rank : 437)	θ value	1.42992e-13 (rank : 442)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	826
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

WNK1_HUMAN
NC score	0.840571 (rank : 438)	θ value	1.16975e-15 (rank : 367)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1158	Shared Neighborhood Hits	898
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

MK08_MOUSE
NC score	0.840041 (rank : 439)	θ value	1.42992e-13 (rank : 441)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

WNK1_MOUSE
NC score	0.839592 (rank : 440)	θ value	8.95645e-16 (rank : 363)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1179	Shared Neighborhood Hits	883
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

MYLK_HUMAN
NC score	0.839535 (rank : 441)	θ value	1.16704e-23 (rank : 214)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1328	Shared Neighborhood Hits	878
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MRCKB_MOUSE
NC score	0.839525 (rank : 442)	θ value	2.49495e-50 (rank : 58)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2180	Shared Neighborhood Hits	955
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MK08_HUMAN
NC score	0.839416 (rank : 443)	θ value	1.42992e-13 (rank : 440)
Query Neighborhood Hits	1804	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

ERN1_MOUSE
NC score	0.839352 (rank : 444)	θ value	1.25267e-09 (rank : 553)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	808
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

DYRK3_HUMAN
NC score	0.838635 (rank : 445)	θ value	4.91457e-14 (rank : 418)
Query Neighborhood Hits	1804	Target Neighborhood Hits	798	Shared Neighborhood Hits	785
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

MK03_HUMAN
NC score	0.838414 (rank : 446)	θ value	2.88119e-14 (rank : 410)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

CDK10_HUMAN
NC score	0.838263 (rank : 447)	θ value	1.2105e-12 (rank : 470)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	824
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

MK03_MOUSE
NC score	0.837903 (rank : 448)	θ value	4.91457e-14 (rank : 420)
Query Neighborhood Hits	1804	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

CTRO_HUMAN
NC score	0.837605 (rank : 449)	θ value	2.95404e-43 (rank : 92)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2092	Shared Neighborhood Hits	963
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CSK22_HUMAN
NC score	0.837471 (rank : 450)	θ value	4.0297e-08 (rank : 608)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

MK10_HUMAN
NC score	0.837002 (rank : 451)	θ value	1.42992e-13 (rank : 443)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

CSK22_MOUSE
NC score	0.836987 (rank : 452)	θ value	8.97725e-08 (rank : 626)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

MK10_MOUSE
NC score	0.836703 (rank : 453)	θ value	2.20605e-14 (rank : 408)
Query Neighborhood Hits	1804	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

M4K4_HUMAN
NC score	0.835974 (rank : 454)	θ value	8.38298e-14 (rank : 430)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1589	Shared Neighborhood Hits	921
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

WNK4_HUMAN
NC score	0.835299 (rank : 455)	θ value	5.62301e-10 (rank : 546)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1043	Shared Neighborhood Hits	864
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

TRIB2_HUMAN
NC score	0.834892 (rank : 456)	θ value	1.2105e-12 (rank : 473)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	652
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

ERN2_HUMAN
NC score	0.834828 (rank : 457)	θ value	3.41135e-07 (rank : 653)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK11_HUMAN
NC score	0.834806 (rank : 458)	θ value	7.84624e-12 (rank : 492)
Query Neighborhood Hits	1804	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

TRIB2_MOUSE
NC score	0.834421 (rank : 459)	θ value	1.58096e-12 (rank : 476)
Query Neighborhood Hits	1804	Target Neighborhood Hits	653	Shared Neighborhood Hits	648
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

MK01_HUMAN
NC score	0.834350 (rank : 460)	θ value	1.2105e-12 (rank : 471)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
NC score	0.834080 (rank : 461)	θ value	1.58096e-12 (rank : 475)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

WNK4_MOUSE
NC score	0.834029 (rank : 462)	θ value	4.30538e-10 (rank : 540)
Query Neighborhood Hits	1804	Target Neighborhood Hits	961	Shared Neighborhood Hits	828
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ERN2_MOUSE
NC score	0.833864 (rank : 463)	θ value	1.29631e-06 (rank : 689)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CDK9_HUMAN
NC score	0.833841 (rank : 464)	θ value	5.43371e-13 (rank : 459)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

MOK_HUMAN
NC score	0.833072 (rank : 465)	θ value	8.40245e-06 (rank : 737)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	801
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

CDK9_MOUSE
NC score	0.832998 (rank : 466)	θ value	1.58096e-12 (rank : 474)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

MOK_MOUSE
NC score	0.832966 (rank : 467)	θ value	5.26297e-08 (rank : 618)
Query Neighborhood Hits	1804	Target Neighborhood Hits	796	Shared Neighborhood Hits	792
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

RIPK5_HUMAN
NC score	0.832749 (rank : 468)	θ value	2.21117e-06 (rank : 706)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	831
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

TAOK2_MOUSE
NC score	0.832713 (rank : 469)	θ value	5.8054e-15 (rank : 396)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1373	Shared Neighborhood Hits	889
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

HIPK4_HUMAN
NC score	0.832633 (rank : 470)	θ value	2.61198e-07 (rank : 646)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	790
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MK04_HUMAN
NC score	0.832533 (rank : 471)	θ value	5.62301e-10 (rank : 544)
Query Neighborhood Hits	1804	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

M3K13_HUMAN
NC score	0.832405 (rank : 472)	θ value	1.52774e-15 (rank : 368)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

RIPK5_MOUSE
NC score	0.832099 (rank : 473)	θ value	2.88788e-06 (rank : 713)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

AAK1_HUMAN
NC score	0.831909 (rank : 474)	θ value	8.40245e-06 (rank : 732)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1077	Shared Neighborhood Hits	917
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

TRIO_HUMAN
NC score	0.831816 (rank : 475)	θ value	4.9032e-22 (rank : 237)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1580	Shared Neighborhood Hits	898
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MRCKB_HUMAN
NC score	0.831447 (rank : 476)	θ value	8.57503e-51 (rank : 57)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2239	Shared Neighborhood Hits	973
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

SPEG_HUMAN
NC score	0.831260 (rank : 477)	θ value	1.68911e-14 (rank : 403)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1083
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CD2L2_HUMAN
NC score	0.831254 (rank : 478)	θ value	6.00763e-12 (rank : 488)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1439	Shared Neighborhood Hits	920
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

KS6C1_MOUSE
NC score	0.831148 (rank : 479)	θ value	1.38178e-16 (rank : 340)
Query Neighborhood Hits	1804	Target Neighborhood Hits	700	Shared Neighborhood Hits	638
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

AAK1_MOUSE
NC score	0.831121 (rank : 480)	θ value	1.87187e-05 (rank : 753)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1051	Shared Neighborhood Hits	909
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KS6C1_HUMAN
NC score	0.830868 (rank : 481)	θ value	6.62687e-19 (rank : 293)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	640
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

DUET_HUMAN
NC score	0.830821 (rank : 482)	θ value	7.32683e-18 (rank : 318)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1220	Shared Neighborhood Hits	846
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MK04_MOUSE
NC score	0.830434 (rank : 483)	θ value	1.9326e-10 (rank : 531)
Query Neighborhood Hits	1804	Target Neighborhood Hits	852	Shared Neighborhood Hits	814
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

CI096_HUMAN
NC score	0.830293 (rank : 484)	θ value	1.69304e-06 (rank : 696)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	797
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

SPEG_MOUSE
NC score	0.830275 (rank : 485)	θ value	1.52774e-15 (rank : 370)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1149
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WNK2_HUMAN
NC score	0.830025 (rank : 486)	θ value	2.98157e-11 (rank : 510)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1407	Shared Neighborhood Hits	979
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

DYR1B_MOUSE
NC score	0.829677 (rank : 487)	θ value	2.13673e-09 (rank : 562)
Query Neighborhood Hits	1804	Target Neighborhood Hits	799	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYR1B_HUMAN
NC score	0.829006 (rank : 488)	θ value	6.21693e-09 (rank : 581)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	792
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

ROCK1_MOUSE
NC score	0.828907 (rank : 489)	θ value	7.24236e-58 (rank : 22)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2126	Shared Neighborhood Hits	945
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CD2L1_HUMAN
NC score	0.828540 (rank : 490)	θ value	3.52202e-12 (rank : 481)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1467	Shared Neighborhood Hits	915
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

M4K4_MOUSE
NC score	0.828516 (rank : 491)	θ value	1.02475e-11 (rank : 494)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1560	Shared Neighborhood Hits	933
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CD2L1_MOUSE
NC score	0.828037 (rank : 492)	θ value	7.84624e-12 (rank : 490)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1463	Shared Neighborhood Hits	919
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

BMP2K_MOUSE
NC score	0.826629 (rank : 493)	θ value	5.81887e-07 (rank : 667)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	792
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

DAPK1_HUMAN
NC score	0.825991 (rank : 494)	θ value	1.80048e-24 (rank : 197)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1130	Shared Neighborhood Hits	843
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

BMP2K_HUMAN
NC score	0.825979 (rank : 495)	θ value	1.29631e-06 (rank : 682)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	794
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

RIPK1_HUMAN
NC score	0.825890 (rank : 496)	θ value	2.88119e-14 (rank : 412)
Query Neighborhood Hits	1804	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TAOK3_MOUSE
NC score	0.824838 (rank : 497)	θ value	2.60593e-15 (rank : 379)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1458	Shared Neighborhood Hits	887
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

MK06_HUMAN
NC score	0.823357 (rank : 498)	θ value	2.98157e-11 (rank : 506)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	795
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.823067 (rank : 499)	θ value	1.33837e-11 (rank : 497)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	795
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

TAOK3_HUMAN
NC score	0.822374 (rank : 500)	θ value	1.16975e-15 (rank : 366)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1494	Shared Neighborhood Hits	898
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

DAPK1_MOUSE
NC score	0.822092 (rank : 501)	θ value	5.23862e-24 (rank : 209)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1138	Shared Neighborhood Hits	842
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

HIPK3_MOUSE
NC score	0.821890 (rank : 502)	θ value	1.42992e-13 (rank : 438)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

M3K12_MOUSE
NC score	0.821080 (rank : 503)	θ value	6.41864e-14 (rank : 423)
Query Neighborhood Hits	1804	Target Neighborhood Hits	957	Shared Neighborhood Hits	862
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	0.821018 (rank : 504)	θ value	6.41864e-14 (rank : 422)
Query Neighborhood Hits	1804	Target Neighborhood Hits	940	Shared Neighborhood Hits	864
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

GAK_HUMAN
NC score	0.820821 (rank : 505)	θ value	5.08577e-11 (rank : 516)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1028	Shared Neighborhood Hits	887
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

IRAK4_MOUSE
NC score	0.820689 (rank : 506)	θ value	1.17247e-07 (rank : 632)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	805
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

RIPK1_MOUSE
NC score	0.820389 (rank : 507)	θ value	1.2105e-12 (rank : 472)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

HIPK3_HUMAN
NC score	0.820266 (rank : 508)	θ value	1.42992e-13 (rank : 437)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	807
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK1_HUMAN
NC score	0.819573 (rank : 509)	θ value	1.09485e-13 (rank : 433)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	801
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.819425 (rank : 510)	θ value	1.09485e-13 (rank : 434)
Query Neighborhood Hits	1804	Target Neighborhood Hits	838	Shared Neighborhood Hits	800
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

M3K7_MOUSE
NC score	0.819397 (rank : 511)	θ value	2.20605e-14 (rank : 406)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

STK10_MOUSE
NC score	0.819286 (rank : 512)	θ value	8.65492e-19 (rank : 294)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2132	Shared Neighborhood Hits	997
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

M3K7_HUMAN
NC score	0.819130 (rank : 513)	θ value	6.41864e-14 (rank : 424)
Query Neighborhood Hits	1804	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

DYR1A_HUMAN
NC score	0.818801 (rank : 514)	θ value	3.64472e-09 (rank : 569)
Query Neighborhood Hits	1804	Target Neighborhood Hits	764	Shared Neighborhood Hits	750
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.818799 (rank : 515)	θ value	3.64472e-09 (rank : 570)
Query Neighborhood Hits	1804	Target Neighborhood Hits	762	Shared Neighborhood Hits	750
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

CD2L6_MOUSE
NC score	0.818286 (rank : 516)	θ value	2.79066e-09 (rank : 566)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

HIPK2_MOUSE
NC score	0.817985 (rank : 517)	θ value	2.43908e-13 (rank : 449)
Query Neighborhood Hits	1804	Target Neighborhood Hits	871	Shared Neighborhood Hits	802
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

CD2L6_HUMAN
NC score	0.817966 (rank : 518)	θ value	2.79066e-09 (rank : 565)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

HIPK2_HUMAN
NC score	0.817943 (rank : 519)	θ value	2.43908e-13 (rank : 448)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	791
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

TESK1_MOUSE
NC score	0.817718 (rank : 520)	θ value	1.02475e-11 (rank : 495)
Query Neighborhood Hits	1804	Target Neighborhood Hits	862	Shared Neighborhood Hits	819
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
NC score	0.816470 (rank : 521)	θ value	5.08577e-11 (rank : 519)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	821
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

WEE1_MOUSE
NC score	0.816389 (rank : 522)	θ value	4.1701e-05 (rank : 779)
Query Neighborhood Hits	1804	Target Neighborhood Hits	794	Shared Neighborhood Hits	766
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

TESK1_HUMAN
NC score	0.816237 (rank : 523)	θ value	1.33837e-11 (rank : 500)
Query Neighborhood Hits	1804	Target Neighborhood Hits	864	Shared Neighborhood Hits	821
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_MOUSE
NC score	0.816094 (rank : 524)	θ value	2.98157e-11 (rank : 509)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	809
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

RIPK3_MOUSE
NC score	0.815901 (rank : 525)	θ value	5.08577e-11 (rank : 518)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	821
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

GAK_MOUSE
NC score	0.815393 (rank : 526)	θ value	1.133e-10 (rank : 525)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	844
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

IRAK4_HUMAN
NC score	0.814326 (rank : 527)	θ value	4.76016e-09 (rank : 577)
Query Neighborhood Hits	1804	Target Neighborhood Hits	816	Shared Neighborhood Hits	805
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

OBSCN_HUMAN
NC score	0.813609 (rank : 528)	θ value	1.37858e-24 (rank : 194)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1063
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CDK8_HUMAN
NC score	0.813121 (rank : 529)	θ value	8.11959e-09 (rank : 587)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

TAOK1_MOUSE
NC score	0.812876 (rank : 530)	θ value	6.85773e-16 (rank : 360)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1720	Shared Neighborhood Hits	932
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

CTRO_MOUSE
NC score	0.812820 (rank : 531)	θ value	2.11701e-41 (rank : 93)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2344	Shared Neighborhood Hits	983
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

TAOK1_HUMAN
NC score	0.812550 (rank : 532)	θ value	6.85773e-16 (rank : 359)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1734	Shared Neighborhood Hits	936
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

DYRK4_HUMAN
NC score	0.811834 (rank : 533)	θ value	1.63604e-09 (rank : 557)
Query Neighborhood Hits	1804	Target Neighborhood Hits	750	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

PRP4B_HUMAN
NC score	0.811534 (rank : 534)	θ value	3.89403e-11 (rank : 513)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1030	Shared Neighborhood Hits	841
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

TRIB1_HUMAN
NC score	0.811029 (rank : 535)	θ value	4.16044e-13 (rank : 458)
Query Neighborhood Hits	1804	Target Neighborhood Hits	598	Shared Neighborhood Hits	583
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

PRP4B_MOUSE
NC score	0.809321 (rank : 536)	θ value	3.89403e-11 (rank : 514)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1040	Shared Neighborhood Hits	842
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

M3K11_HUMAN
NC score	0.808670 (rank : 537)	θ value	4.59992e-12 (rank : 484)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1136	Shared Neighborhood Hits	911
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RIPK3_HUMAN
NC score	0.808451 (rank : 538)	θ value	1.133e-10 (rank : 526)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	808
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

TRIB1_MOUSE
NC score	0.806844 (rank : 539)	θ value	6.00763e-12 (rank : 489)
Query Neighborhood Hits	1804	Target Neighborhood Hits	593	Shared Neighborhood Hits	586
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

WEE1_HUMAN
NC score	0.805882 (rank : 540)	θ value	0.00102713 (rank : 842)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	746
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

M3K9_HUMAN
NC score	0.805314 (rank : 541)	θ value	9.26847e-13 (rank : 467)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1123	Shared Neighborhood Hits	880
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.805147 (rank : 542)	θ value	4.91457e-14 (rank : 419)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1071	Shared Neighborhood Hits	853
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

LIMK2_HUMAN
NC score	0.803328 (rank : 543)	θ value	4.16044e-13 (rank : 457)
Query Neighborhood Hits	1804	Target Neighborhood Hits	986	Shared Neighborhood Hits	862
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

UHMK1_HUMAN
NC score	0.802608 (rank : 544)	θ value	0.00035302 (rank : 826)
Query Neighborhood Hits	1804	Target Neighborhood Hits	808	Shared Neighborhood Hits	766
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MOS_HUMAN
NC score	0.800944 (rank : 545)	θ value	4.45536e-07 (rank : 664)
Query Neighborhood Hits	1804	Target Neighborhood Hits	829	Shared Neighborhood Hits	820
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

UHMK1_MOUSE
NC score	0.800808 (rank : 546)	θ value	0.00035302 (rank : 827)
Query Neighborhood Hits	1804	Target Neighborhood Hits	809	Shared Neighborhood Hits	766
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

LIMK2_MOUSE
NC score	0.800207 (rank : 547)	θ value	2.0648e-12 (rank : 478)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	861
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TRIB3_MOUSE
NC score	0.799703 (rank : 548)	θ value	1.09485e-13 (rank : 436)
Query Neighborhood Hits	1804	Target Neighborhood Hits	578	Shared Neighborhood Hits	573
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

WEE1B_HUMAN
NC score	0.799426 (rank : 549)	θ value	8.40245e-06 (rank : 739)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	775
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

BRAF1_HUMAN
NC score	0.799164 (rank : 550)	θ value	1.63604e-09 (rank : 555)
Query Neighborhood Hits	1804	Target Neighborhood Hits	883	Shared Neighborhood Hits	826
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RAF1_MOUSE
NC score	0.798643 (rank : 551)	θ value	1.17247e-07 (rank : 635)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

LIMK1_HUMAN
NC score	0.798042 (rank : 552)	θ value	1.80466e-16 (rank : 344)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	870
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.797822 (rank : 553)	θ value	8.10077e-17 (rank : 334)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1008	Shared Neighborhood Hits	867
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

RAF1_HUMAN
NC score	0.797785 (rank : 554)	θ value	1.17247e-07 (rank : 634)
Query Neighborhood Hits	1804	Target Neighborhood Hits	886	Shared Neighborhood Hits	834
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MLTK_MOUSE
NC score	0.797465 (rank : 555)	θ value	3.64472e-09 (rank : 573)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	825
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.797116 (rank : 556)	θ value	4.76016e-09 (rank : 578)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	837
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MOS_MOUSE
NC score	0.796772 (rank : 557)	θ value	2.88788e-06 (rank : 711)
Query Neighborhood Hits	1804	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

CLK1_HUMAN
NC score	0.796020 (rank : 558)	θ value	2.98157e-11 (rank : 505)
Query Neighborhood Hits	1804	Target Neighborhood Hits	756	Shared Neighborhood Hits	741
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

ARAF_HUMAN
NC score	0.795262 (rank : 559)	θ value	8.11959e-09 (rank : 585)
Query Neighborhood Hits	1804	Target Neighborhood Hits	924	Shared Neighborhood Hits	856
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
NC score	0.794431 (rank : 560)	θ value	1.80886e-08 (rank : 601)
Query Neighborhood Hits	1804	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CLK1_MOUSE
NC score	0.794017 (rank : 561)	θ value	6.64225e-11 (rank : 521)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	751
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

WEE1B_MOUSE
NC score	0.792735 (rank : 562)	θ value	8.40245e-06 (rank : 740)
Query Neighborhood Hits	1804	Target Neighborhood Hits	765	Shared Neighborhood Hits	738
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CLK2_HUMAN
NC score	0.788793 (rank : 563)	θ value	1.33837e-11 (rank : 496)
Query Neighborhood Hits	1804	Target Neighborhood Hits	752	Shared Neighborhood Hits	736
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

PINK1_MOUSE
NC score	0.788623 (rank : 564)	θ value	1.29631e-06 (rank : 694)
Query Neighborhood Hits	1804	Target Neighborhood Hits	726	Shared Neighborhood Hits	718
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

M3KL4_HUMAN
NC score	0.786829 (rank : 565)	θ value	1.47974e-10 (rank : 527)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1087	Shared Neighborhood Hits	850
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

CLK4_HUMAN
NC score	0.785537 (rank : 566)	θ value	1.63604e-09 (rank : 556)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
NC score	0.783244 (rank : 567)	θ value	2.79066e-09 (rank : 567)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	750
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TRIB3_HUMAN
NC score	0.780422 (rank : 568)	θ value	4.59992e-12 (rank : 486)
Query Neighborhood Hits	1804	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

PINK1_HUMAN
NC score	0.778543 (rank : 569)	θ value	2.88788e-06 (rank : 712)
Query Neighborhood Hits	1804	Target Neighborhood Hits	741	Shared Neighborhood Hits	725
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

KSR2_HUMAN
NC score	0.777780 (rank : 570)	θ value	5.81887e-07 (rank : 671)
Query Neighborhood Hits	1804	Target Neighborhood Hits	920	Shared Neighborhood Hits	840
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

CLK2_MOUSE
NC score	0.774864 (rank : 571)	θ value	5.08577e-11 (rank : 515)
Query Neighborhood Hits	1804	Target Neighborhood Hits	743	Shared Neighborhood Hits	730
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

RIPK2_MOUSE
NC score	0.774806 (rank : 572)	θ value	1.33837e-11 (rank : 498)
Query Neighborhood Hits	1804	Target Neighborhood Hits	776	Shared Neighborhood Hits	752
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

MYO3A_MOUSE
NC score	0.773837 (rank : 573)	θ value	3.40345e-15 (rank : 382)
Query Neighborhood Hits	1804	Target Neighborhood Hits	902	Shared Neighborhood Hits	830
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

JAK3_MOUSE
NC score	0.773231 (rank : 574)	θ value	4.30538e-10 (rank : 538)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	805
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

RIPK2_HUMAN
NC score	0.772399 (rank : 575)	θ value	2.98157e-11 (rank : 508)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	752
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

AL2S2_HUMAN
NC score	0.765995 (rank : 576)	θ value	2.88788e-06 (rank : 707)
Query Neighborhood Hits	1804	Target Neighborhood Hits	727	Shared Neighborhood Hits	713
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

MYO3A_HUMAN
NC score	0.765709 (rank : 577)	θ value	5.8054e-15 (rank : 393)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1033	Shared Neighborhood Hits	848
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

JAK3_HUMAN
NC score	0.764843 (rank : 578)	θ value	5.62301e-10 (rank : 543)
Query Neighborhood Hits	1804	Target Neighborhood Hits	827	Shared Neighborhood Hits	812
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

MYO3B_HUMAN
NC score	0.764109 (rank : 579)	θ value	3.07829e-16 (rank : 347)
Query Neighborhood Hits	1804	Target Neighborhood Hits	923	Shared Neighborhood Hits	839
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

JAK2_HUMAN
NC score	0.760879 (rank : 580)	θ value	8.11959e-09 (rank : 588)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	822
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CLK3_HUMAN
NC score	0.760824 (rank : 581)	θ value	4.76016e-09 (rank : 574)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	731
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.760189 (rank : 582)	θ value	4.76016e-09 (rank : 575)
Query Neighborhood Hits	1804	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

JAK2_MOUSE
NC score	0.760015 (rank : 583)	θ value	1.06045e-08 (rank : 598)
Query Neighborhood Hits	1804	Target Neighborhood Hits	839	Shared Neighborhood Hits	818
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

TYK2_HUMAN
NC score	0.755355 (rank : 584)	θ value	8.97725e-08 (rank : 630)
Query Neighborhood Hits	1804	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

AL2S2_MOUSE
NC score	0.751498 (rank : 585)	θ value	8.40245e-06 (rank : 733)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	691
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

TYK2_MOUSE
NC score	0.748561 (rank : 586)	θ value	5.81887e-07 (rank : 672)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

KSR1_MOUSE
NC score	0.747915 (rank : 587)	θ value	2.61198e-07 (rank : 647)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	819
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

CDC7_MOUSE
NC score	0.747332 (rank : 588)	θ value	3.77169e-06 (rank : 714)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CDC7_HUMAN
NC score	0.745079 (rank : 589)	θ value	1.09739e-05 (rank : 741)
Query Neighborhood Hits	1804	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

FES_MOUSE
NC score	0.744763 (rank : 590)	θ value	3.89403e-11 (rank : 512)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	818
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.743702 (rank : 591)	θ value	8.67504e-11 (rank : 522)
Query Neighborhood Hits	1804	Target Neighborhood Hits	978	Shared Neighborhood Hits	809
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

LRRK1_HUMAN
NC score	0.743158 (rank : 592)	θ value	8.11959e-09 (rank : 589)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1237	Shared Neighborhood Hits	815
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

JAK1_HUMAN
NC score	0.743033 (rank : 593)	θ value	3.64472e-09 (rank : 572)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	822
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

LRRK1_MOUSE
NC score	0.740290 (rank : 594)	θ value	9.59137e-10 (rank : 551)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1267	Shared Neighborhood Hits	823
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

KSR1_HUMAN
NC score	0.734993 (rank : 595)	θ value	4.92598e-06 (rank : 723)
Query Neighborhood Hits	1804	Target Neighborhood Hits	867	Shared Neighborhood Hits	804
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

JAK1_MOUSE
NC score	0.734297 (rank : 596)	θ value	1.06045e-08 (rank : 597)
Query Neighborhood Hits	1804	Target Neighborhood Hits	854	Shared Neighborhood Hits	821
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

PTK6_MOUSE
NC score	0.732280 (rank : 597)	θ value	9.59137e-10 (rank : 552)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	842
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

IRAK1_HUMAN
NC score	0.731714 (rank : 598)	θ value	0.000270298 (rank : 814)
Query Neighborhood Hits	1804	Target Neighborhood Hits	820	Shared Neighborhood Hits	770
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

PTK6_HUMAN
NC score	0.731670 (rank : 599)	θ value	1.9326e-10 (rank : 532)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	842
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

IRAK1_MOUSE
NC score	0.730312 (rank : 600)	θ value	0.000158464 (rank : 802)
Query Neighborhood Hits	1804	Target Neighborhood Hits	784	Shared Neighborhood Hits	752
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

ZAP70_HUMAN
NC score	0.727544 (rank : 601)	θ value	8.11959e-09 (rank : 593)
Query Neighborhood Hits	1804	Target Neighborhood Hits	893	Shared Neighborhood Hits	813
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TEC_MOUSE
NC score	0.727375 (rank : 602)	θ value	4.76016e-09 (rank : 580)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1006	Shared Neighborhood Hits	830
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KSYK_HUMAN
NC score	0.726553 (rank : 603)	θ value	1.99992e-07 (rank : 641)
Query Neighborhood Hits	1804	Target Neighborhood Hits	901	Shared Neighborhood Hits	810
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.726419 (rank : 604)	θ value	2.61198e-07 (rank : 648)
Query Neighborhood Hits	1804	Target Neighborhood Hits	944	Shared Neighborhood Hits	829
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ZAP70_MOUSE
NC score	0.725815 (rank : 605)	θ value	7.34386e-10 (rank : 549)
Query Neighborhood Hits	1804	Target Neighborhood Hits	905	Shared Neighborhood Hits	819
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FER_HUMAN
NC score	0.725114 (rank : 606)	θ value	2.52405e-10 (rank : 533)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1278	Shared Neighborhood Hits	841
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CSK_MOUSE
NC score	0.724952 (rank : 607)	θ value	3.41135e-07 (rank : 651)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	831
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

TEC_HUMAN
NC score	0.721461 (rank : 608)	θ value	8.11959e-09 (rank : 592)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1006	Shared Neighborhood Hits	831
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

FAK1_HUMAN
NC score	0.721270 (rank : 609)	θ value	1.53129e-07 (rank : 637)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.720959 (rank : 610)	θ value	1.53129e-07 (rank : 638)
Query Neighborhood Hits	1804	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

TXK_HUMAN
NC score	0.719869 (rank : 611)	θ value	4.59992e-12 (rank : 487)
Query Neighborhood Hits	1804	Target Neighborhood Hits	971	Shared Neighborhood Hits	820
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABL1_MOUSE
NC score	0.717044 (rank : 612)	θ value	5.62301e-10 (rank : 541)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1178	Shared Neighborhood Hits	920
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK_HUMAN
NC score	0.716906 (rank : 613)	θ value	5.81887e-07 (rank : 668)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	830
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

LRRK2_HUMAN
NC score	0.715911 (rank : 614)	θ value	3.08544e-08 (rank : 607)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1382	Shared Neighborhood Hits	830
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

ABL1_HUMAN
NC score	0.715365 (rank : 615)	θ value	4.30538e-10 (rank : 536)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1220	Shared Neighborhood Hits	930
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BMX_HUMAN
NC score	0.713530 (rank : 616)	θ value	4.45536e-07 (rank : 659)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	808
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.712929 (rank : 617)	θ value	1.29631e-06 (rank : 683)
Query Neighborhood Hits	1804	Target Neighborhood Hits	912	Shared Neighborhood Hits	794
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TTBK1_HUMAN
NC score	0.712684 (rank : 618)	θ value	4.1701e-05 (rank : 778)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	822
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

ABL2_HUMAN
NC score	0.712539 (rank : 619)	θ value	6.64225e-11 (rank : 520)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1045	Shared Neighborhood Hits	843
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FAK2_MOUSE
NC score	0.711016 (rank : 620)	θ value	7.34386e-10 (rank : 548)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	803
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ITK_HUMAN
NC score	0.710839 (rank : 621)	θ value	4.0297e-08 (rank : 610)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1016	Shared Neighborhood Hits	830
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BTK_HUMAN
NC score	0.710634 (rank : 622)	θ value	6.87365e-08 (rank : 621)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	828
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ITK_MOUSE
NC score	0.710508 (rank : 623)	θ value	1.06045e-08 (rank : 596)
Query Neighborhood Hits	1804	Target Neighborhood Hits	985	Shared Neighborhood Hits	830
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

BTK_MOUSE
NC score	0.710247 (rank : 624)	θ value	6.87365e-08 (rank : 622)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1017	Shared Neighborhood Hits	830
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

TNI3K_MOUSE
NC score	0.709340 (rank : 625)	θ value	1.47974e-10 (rank : 528)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1079	Shared Neighborhood Hits	804
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

MATK_MOUSE
NC score	0.709001 (rank : 626)	θ value	1.29631e-06 (rank : 693)
Query Neighborhood Hits	1804	Target Neighborhood Hits	952	Shared Neighborhood Hits	827
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

LYN_MOUSE
NC score	0.707004 (rank : 627)	θ value	2.79066e-09 (rank : 568)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	848
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.706859 (rank : 628)	θ value	1.63604e-09 (rank : 558)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1022	Shared Neighborhood Hits	846
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FAK2_HUMAN
NC score	0.706489 (rank : 629)	θ value	7.34386e-10 (rank : 547)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	800
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TITIN_HUMAN
NC score	0.705786 (rank : 630)	θ value	1.29331e-14 (rank : 402)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1098
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

FRK_HUMAN
NC score	0.705428 (rank : 631)	θ value	6.87365e-08 (rank : 624)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	847
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MATK_HUMAN
NC score	0.705183 (rank : 632)	θ value	4.45536e-07 (rank : 663)
Query Neighborhood Hits	1804	Target Neighborhood Hits	954	Shared Neighborhood Hits	823
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

KC1G1_MOUSE
NC score	0.701902 (rank : 633)	θ value	1.87187e-05 (rank : 754)
Query Neighborhood Hits	1804	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

TXK_MOUSE
NC score	0.701787 (rank : 634)	θ value	2.61198e-07 (rank : 650)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	815
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SRMS_MOUSE
NC score	0.701277 (rank : 635)	θ value	0.000461057 (rank : 831)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	829
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TNI3K_HUMAN
NC score	0.701241 (rank : 636)	θ value	5.62301e-10 (rank : 545)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1084	Shared Neighborhood Hits	809
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

KC1G1_HUMAN
NC score	0.700678 (rank : 637)	θ value	1.43324e-05 (rank : 750)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1AL_HUMAN
NC score	0.697717 (rank : 638)	θ value	0.000461057 (rank : 830)
Query Neighborhood Hits	1804	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

TTBK2_HUMAN
NC score	0.697636 (rank : 639)	θ value	0.00020696 (rank : 811)
Query Neighborhood Hits	1804	Target Neighborhood Hits	822	Shared Neighborhood Hits	741
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

LCK_MOUSE
NC score	0.696305 (rank : 640)	θ value	1.06045e-08 (rank : 599)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	832
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LRRK2_MOUSE
NC score	0.695692 (rank : 641)	θ value	1.17247e-07 (rank : 633)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1359	Shared Neighborhood Hits	821
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

KC1G3_HUMAN
NC score	0.695579 (rank : 642)	θ value	5.44631e-05 (rank : 784)
Query Neighborhood Hits	1804	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KC1A_HUMAN
NC score	0.695543 (rank : 643)	θ value	0.000158464 (rank : 803)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.695543 (rank : 644)	θ value	0.000158464 (rank : 804)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

SRMS_HUMAN
NC score	0.695035 (rank : 645)	θ value	0.00035302 (rank : 823)
Query Neighborhood Hits	1804	Target Neighborhood Hits	946	Shared Neighborhood Hits	828
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TTBK2_MOUSE
NC score	0.694821 (rank : 646)	θ value	0.00020696 (rank : 812)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	738
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TNK1_MOUSE
NC score	0.694189 (rank : 647)	θ value	4.0297e-08 (rank : 613)
Query Neighborhood Hits	1804	Target Neighborhood Hits	806	Shared Neighborhood Hits	780
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

FYN_HUMAN
NC score	0.690674 (rank : 648)	θ value	3.08544e-08 (rank : 606)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

LCK_HUMAN
NC score	0.689986 (rank : 649)	θ value	1.53129e-07 (rank : 639)
Query Neighborhood Hits	1804	Target Neighborhood Hits	987	Shared Neighborhood Hits	836
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLK_HUMAN
NC score	0.689424 (rank : 650)	θ value	3.08544e-08 (rank : 605)
Query Neighborhood Hits	1804	Target Neighborhood Hits	994	Shared Neighborhood Hits	834
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
NC score	0.689218 (rank : 651)	θ value	2.88788e-06 (rank : 709)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1035	Shared Neighborhood Hits	845
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KC1D_HUMAN
NC score	0.687630 (rank : 652)	θ value	3.19293e-05 (rank : 765)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	728
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.687605 (rank : 653)	θ value	3.19293e-05 (rank : 766)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	728
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

EGFR_MOUSE
NC score	0.686456 (rank : 654)	θ value	2.13673e-09 (rank : 563)
Query Neighborhood Hits	1804	Target Neighborhood Hits	927	Shared Neighborhood Hits	814
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

BLK_MOUSE
NC score	0.686087 (rank : 655)	θ value	8.11959e-09 (rank : 586)
Query Neighborhood Hits	1804	Target Neighborhood Hits	992	Shared Neighborhood Hits	836
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EGFR_HUMAN
NC score	0.686042 (rank : 656)	θ value	4.76016e-09 (rank : 576)
Query Neighborhood Hits	1804	Target Neighborhood Hits	939	Shared Neighborhood Hits	814
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

KC1E_HUMAN
NC score	0.685909 (rank : 657)	θ value	3.19293e-05 (rank : 767)
Query Neighborhood Hits	1804	Target Neighborhood Hits	732	Shared Neighborhood Hits	725
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.685891 (rank : 658)	θ value	3.19293e-05 (rank : 768)
Query Neighborhood Hits	1804	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

ACK1_HUMAN
NC score	0.685614 (rank : 659)	θ value	5.44631e-05 (rank : 780)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1140	Shared Neighborhood Hits	944
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

RET_HUMAN
NC score	0.684607 (rank : 660)	θ value	3.77169e-06 (rank : 717)
Query Neighborhood Hits	1804	Target Neighborhood Hits	873	Shared Neighborhood Hits	807
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
NC score	0.684358 (rank : 661)	θ value	1.29631e-06 (rank : 695)
Query Neighborhood Hits	1804	Target Neighborhood Hits	884	Shared Neighborhood Hits	806
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TNK1_HUMAN
NC score	0.683494 (rank : 662)	θ value	3.41135e-07 (rank : 656)
Query Neighborhood Hits	1804	Target Neighborhood Hits	815	Shared Neighborhood Hits	783
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

ACK1_MOUSE
NC score	0.683466 (rank : 663)	θ value	4.1701e-05 (rank : 771)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1080	Shared Neighborhood Hits	916
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

TIE2_HUMAN
NC score	0.682773 (rank : 664)	θ value	2.61198e-07 (rank : 649)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1192	Shared Neighborhood Hits	822
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

HCK_MOUSE
NC score	0.682588 (rank : 665)	θ value	4.92598e-06 (rank : 722)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1029	Shared Neighborhood Hits	842
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SRC_MOUSE
NC score	0.682365 (rank : 666)	θ value	7.59969e-07 (rank : 675)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1033	Shared Neighborhood Hits	832
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FYN_MOUSE
NC score	0.682345 (rank : 667)	θ value	6.43352e-06 (rank : 729)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1073	Shared Neighborhood Hits	853
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

TIE2_MOUSE
NC score	0.681963 (rank : 668)	θ value	1.99992e-07 (rank : 642)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1204	Shared Neighborhood Hits	823
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

ERBB4_HUMAN
NC score	0.681583 (rank : 669)	θ value	2.61198e-07 (rank : 645)
Query Neighborhood Hits	1804	Target Neighborhood Hits	910	Shared Neighborhood Hits	806
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

SRC_HUMAN
NC score	0.681315 (rank : 670)	θ value	3.41135e-07 (rank : 655)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1058	Shared Neighborhood Hits	843
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

EPHA5_MOUSE
NC score	0.680593 (rank : 671)	θ value	5.26297e-08 (rank : 616)
Query Neighborhood Hits	1804	Target Neighborhood Hits	950	Shared Neighborhood Hits	820
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FGFR2_MOUSE
NC score	0.679751 (rank : 672)	θ value	1.29631e-06 (rank : 691)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1062	Shared Neighborhood Hits	817
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

NTRK2_HUMAN
NC score	0.677929 (rank : 673)	θ value	4.0297e-08 (rank : 612)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1081	Shared Neighborhood Hits	811
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

FGFR2_HUMAN
NC score	0.677769 (rank : 674)	θ value	1.29631e-06 (rank : 690)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1062	Shared Neighborhood Hits	815
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

NTRK2_MOUSE
NC score	0.677286 (rank : 675)	θ value	8.97725e-08 (rank : 628)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	811
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

ERBB2_MOUSE
NC score	0.677238 (rank : 676)	θ value	3.64472e-09 (rank : 571)
Query Neighborhood Hits	1804	Target Neighborhood Hits	918	Shared Neighborhood Hits	824
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB2_HUMAN
NC score	0.675105 (rank : 677)	θ value	5.62301e-10 (rank : 542)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1073	Shared Neighborhood Hits	884
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

YES_HUMAN
NC score	0.674791 (rank : 678)	θ value	2.44474e-05 (rank : 762)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1059	Shared Neighborhood Hits	847
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGFR1_MOUSE
NC score	0.674565 (rank : 679)	θ value	1.69304e-06 (rank : 699)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1068	Shared Neighborhood Hits	820
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.674454 (rank : 680)	θ value	1.69304e-06 (rank : 698)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1069	Shared Neighborhood Hits	821
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

YES_MOUSE
NC score	0.674336 (rank : 681)	θ value	2.44474e-05 (rank : 763)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1052	Shared Neighborhood Hits	840
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

KC1G2_MOUSE
NC score	0.673721 (rank : 682)	θ value	7.1131e-05 (rank : 787)
Query Neighborhood Hits	1804	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

AVR2A_MOUSE
NC score	0.673437 (rank : 683)	θ value	0.00390308 (rank : 871)
Query Neighborhood Hits	1804	Target Neighborhood Hits	767	Shared Neighborhood Hits	759
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.673423 (rank : 684)	θ value	0.00390308 (rank : 870)
Query Neighborhood Hits	1804	Target Neighborhood Hits	767	Shared Neighborhood Hits	759
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

EPHB1_HUMAN
NC score	0.671350 (rank : 685)	θ value	8.97725e-08 (rank : 627)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	819
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

MET_MOUSE
NC score	0.670978 (rank : 686)	θ value	3.77169e-06 (rank : 716)
Query Neighborhood Hits	1804	Target Neighborhood Hits	844	Shared Neighborhood Hits	795
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

FGR_HUMAN
NC score	0.670215 (rank : 687)	θ value	2.44474e-05 (rank : 760)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1067	Shared Neighborhood Hits	851
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

KC1G2_HUMAN
NC score	0.670011 (rank : 688)	θ value	9.29e-05 (rank : 791)
Query Neighborhood Hits	1804	Target Neighborhood Hits	693	Shared Neighborhood Hits	691
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

RON_HUMAN
NC score	0.669103 (rank : 689)	θ value	0.00035302 (rank : 822)
Query Neighborhood Hits	1804	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TGFR2_HUMAN
NC score	0.668672 (rank : 690)	θ value	0.0961366 (rank : 1063)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	738
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

STYK1_HUMAN
NC score	0.668653 (rank : 691)	θ value	0.00390308 (rank : 877)
Query Neighborhood Hits	1804	Target Neighborhood Hits	786	Shared Neighborhood Hits	770
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

FGFR3_HUMAN
NC score	0.668585 (rank : 692)	θ value	1.69304e-06 (rank : 700)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1042	Shared Neighborhood Hits	815
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

MET_HUMAN
NC score	0.667809 (rank : 693)	θ value	2.88788e-06 (rank : 710)
Query Neighborhood Hits	1804	Target Neighborhood Hits	831	Shared Neighborhood Hits	793
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TGFR2_MOUSE
NC score	0.667775 (rank : 694)	θ value	0.0961366 (rank : 1064)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	739
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ROR1_MOUSE
NC score	0.666395 (rank : 695)	θ value	6.87365e-08 (rank : 625)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1025	Shared Neighborhood Hits	816
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

IRAK2_HUMAN
NC score	0.665984 (rank : 696)	θ value	0.00020696 (rank : 807)
Query Neighborhood Hits	1804	Target Neighborhood Hits	714	Shared Neighborhood Hits	688
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

FGR_MOUSE
NC score	0.665549 (rank : 697)	θ value	1.43324e-05 (rank : 749)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1069	Shared Neighborhood Hits	848
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

EPHA7_MOUSE
NC score	0.665403 (rank : 698)	θ value	5.26297e-08 (rank : 617)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1025	Shared Neighborhood Hits	825
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

AATK_HUMAN
NC score	0.664988 (rank : 699)	θ value	0.0113563 (rank : 909)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1243	Shared Neighborhood Hits	963
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ROR1_HUMAN
NC score	0.664816 (rank : 700)	θ value	6.21693e-09 (rank : 584)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1018	Shared Neighborhood Hits	812
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

EPHA3_HUMAN
NC score	0.664712 (rank : 701)	θ value	9.92553e-07 (rank : 677)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	821
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA7_HUMAN
NC score	0.664545 (rank : 702)	θ value	1.53129e-07 (rank : 636)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1053	Shared Neighborhood Hits	830
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

FGFR3_MOUSE
NC score	0.663418 (rank : 703)	θ value	1.09739e-05 (rank : 744)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1059	Shared Neighborhood Hits	815
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

DDR2_MOUSE
NC score	0.662725 (rank : 704)	θ value	9.59137e-10 (rank : 550)
Query Neighborhood Hits	1804	Target Neighborhood Hits	813	Shared Neighborhood Hits	773
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA5_HUMAN
NC score	0.662639 (rank : 705)	θ value	1.06045e-08 (rank : 595)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	825
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ACVR1_MOUSE
NC score	0.661232 (rank : 706)	θ value	0.00035302 (rank : 818)
Query Neighborhood Hits	1804	Target Neighborhood Hits	768	Shared Neighborhood Hits	756
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

EPHB4_MOUSE
NC score	0.660496 (rank : 707)	θ value	1.29631e-06 (rank : 688)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1013	Shared Neighborhood Hits	817
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

AVR2B_MOUSE
NC score	0.659940 (rank : 708)	θ value	0.0252991 (rank : 957)
Query Neighborhood Hits	1804	Target Neighborhood Hits	749	Shared Neighborhood Hits	738
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

RON_MOUSE
NC score	0.659803 (rank : 709)	θ value	4.1701e-05 (rank : 776)
Query Neighborhood Hits	1804	Target Neighborhood Hits	836	Shared Neighborhood Hits	794
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

AVR2B_HUMAN
NC score	0.659750 (rank : 710)	θ value	0.0252991 (rank : 956)
Query Neighborhood Hits	1804	Target Neighborhood Hits	748	Shared Neighborhood Hits	738
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

TIE1_MOUSE
NC score	0.659553 (rank : 711)	θ value	1.69304e-06 (rank : 703)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1266	Shared Neighborhood Hits	832
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHB4_HUMAN
NC score	0.657730 (rank : 712)	θ value	1.29631e-06 (rank : 687)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	818
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHA2_HUMAN
NC score	0.657673 (rank : 713)	θ value	4.92598e-06 (rank : 720)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1021	Shared Neighborhood Hits	828
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA3_MOUSE
NC score	0.657214 (rank : 714)	θ value	3.77169e-06 (rank : 715)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1009	Shared Neighborhood Hits	827
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

TIE1_HUMAN
NC score	0.656902 (rank : 715)	θ value	4.1701e-05 (rank : 777)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1241	Shared Neighborhood Hits	829
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA2_MOUSE
NC score	0.656607 (rank : 716)	θ value	6.43352e-06 (rank : 728)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	822
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

DDR2_HUMAN
NC score	0.656257 (rank : 717)	θ value	4.0297e-08 (rank : 609)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	774
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHB2_MOUSE
NC score	0.655818 (rank : 718)	θ value	9.92553e-07 (rank : 680)
Query Neighborhood Hits	1804	Target Neighborhood Hits	982	Shared Neighborhood Hits	814
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

ACVR1_HUMAN
NC score	0.655784 (rank : 719)	θ value	0.000461057 (rank : 828)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	750
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

EPHB2_HUMAN
NC score	0.655759 (rank : 720)	θ value	9.92553e-07 (rank : 679)
Query Neighborhood Hits	1804	Target Neighborhood Hits	983	Shared Neighborhood Hits	814
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

SCYL2_HUMAN
NC score	0.655105 (rank : 721)	θ value	0.00509761 (rank : 885)
Query Neighborhood Hits	1804	Target Neighborhood Hits	632	Shared Neighborhood Hits	571
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

MLKL_MOUSE
NC score	0.654546 (rank : 722)	θ value	2.44474e-05 (rank : 761)
Query Neighborhood Hits	1804	Target Neighborhood Hits	707	Shared Neighborhood Hits	691
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHA4_HUMAN
NC score	0.653786 (rank : 723)	θ value	4.45536e-07 (rank : 661)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	818
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.653536 (rank : 724)	θ value	4.45536e-07 (rank : 662)
Query Neighborhood Hits	1804	Target Neighborhood Hits	982	Shared Neighborhood Hits	818
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA8_HUMAN
NC score	0.653389 (rank : 725)	θ value	6.87365e-08 (rank : 623)
Query Neighborhood Hits	1804	Target Neighborhood Hits	956	Shared Neighborhood Hits	814
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FGFR4_HUMAN
NC score	0.652929 (rank : 726)	θ value	1.29631e-06 (rank : 692)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	808
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

AATK_MOUSE
NC score	0.652886 (rank : 727)	θ value	0.00509761 (rank : 880)
Query Neighborhood Hits	1804	Target Neighborhood Hits	942	Shared Neighborhood Hits	836
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

EPHA1_HUMAN
NC score	0.652394 (rank : 728)	θ value	4.45536e-07 (rank : 660)
Query Neighborhood Hits	1804	Target Neighborhood Hits	997	Shared Neighborhood Hits	815
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

NTRK3_HUMAN
NC score	0.652241 (rank : 729)	θ value	4.76016e-09 (rank : 579)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1115	Shared Neighborhood Hits	797
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

STYK1_MOUSE
NC score	0.652123 (rank : 730)	θ value	0.00390308 (rank : 878)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	767
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

BMR1A_HUMAN
NC score	0.651897 (rank : 731)	θ value	0.00298849 (rank : 865)
Query Neighborhood Hits	1804	Target Neighborhood Hits	759	Shared Neighborhood Hits	746
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

NTRK1_HUMAN
NC score	0.651446 (rank : 732)	θ value	4.0297e-08 (rank : 611)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1023	Shared Neighborhood Hits	789
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

TYRO3_HUMAN
NC score	0.651043 (rank : 733)	θ value	1.99992e-07 (rank : 643)
Query Neighborhood Hits	1804	Target Neighborhood Hits	995	Shared Neighborhood Hits	779
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

ROS_HUMAN
NC score	0.651006 (rank : 734)	θ value	1.87187e-05 (rank : 756)
Query Neighborhood Hits	1804	Target Neighborhood Hits	907	Shared Neighborhood Hits	768
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

BMR1A_MOUSE
NC score	0.650697 (rank : 735)	θ value	0.00390308 (rank : 872)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	745
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

TYRO3_MOUSE
NC score	0.650265 (rank : 736)	θ value	5.81887e-07 (rank : 673)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1007	Shared Neighborhood Hits	779
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_MOUSE
NC score	0.649331 (rank : 737)	θ value	8.40245e-06 (rank : 738)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	772
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

INSR_HUMAN
NC score	0.648966 (rank : 738)	θ value	1.09739e-05 (rank : 745)
Query Neighborhood Hits	1804	Target Neighborhood Hits	963	Shared Neighborhood Hits	803
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
NC score	0.648027 (rank : 739)	θ value	8.40245e-06 (rank : 736)
Query Neighborhood Hits	1804	Target Neighborhood Hits	968	Shared Neighborhood Hits	799
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

BMPR2_HUMAN
NC score	0.647417 (rank : 740)	θ value	1.38499e-08 (rank : 600)
Query Neighborhood Hits	1804	Target Neighborhood Hits	736	Shared Neighborhood Hits	708
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

EPHA8_MOUSE
NC score	0.647341 (rank : 741)	θ value	2.61198e-07 (rank : 644)
Query Neighborhood Hits	1804	Target Neighborhood Hits	969	Shared Neighborhood Hits	809
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

BMPR2_MOUSE
NC score	0.646174 (rank : 742)	θ value	1.80886e-08 (rank : 602)
Query Neighborhood Hits	1804	Target Neighborhood Hits	738	Shared Neighborhood Hits	710
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ANKK1_MOUSE
NC score	0.645424 (rank : 743)	θ value	7.09661e-13 (rank : 463)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1072	Shared Neighborhood Hits	806
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

UFO_HUMAN
NC score	0.645072 (rank : 744)	θ value	3.77169e-06 (rank : 718)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	779
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHB3_HUMAN
NC score	0.642970 (rank : 745)	θ value	1.29631e-06 (rank : 686)
Query Neighborhood Hits	1804	Target Neighborhood Hits	996	Shared Neighborhood Hits	826
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

BMR1B_MOUSE
NC score	0.642407 (rank : 746)	θ value	0.00102713 (rank : 839)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	744
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

EPHA1_MOUSE
NC score	0.641233 (rank : 747)	θ value	1.09739e-05 (rank : 743)
Query Neighborhood Hits	1804	Target Neighborhood Hits	958	Shared Neighborhood Hits	803
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

BMR1B_HUMAN
NC score	0.641009 (rank : 748)	θ value	0.00134147 (rank : 844)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	743
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

EPHB3_MOUSE
NC score	0.640401 (rank : 749)	θ value	4.92598e-06 (rank : 721)
Query Neighborhood Hits	1804	Target Neighborhood Hits	996	Shared Neighborhood Hits	823
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

ACV1B_MOUSE
NC score	0.638837 (rank : 750)	θ value	0.0148317 (rank : 924)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	746
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.638791 (rank : 751)	θ value	0.0148317 (rank : 923)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	747
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ERBB3_MOUSE
NC score	0.638470 (rank : 752)	θ value	0.00665767 (rank : 891)
Query Neighborhood Hits	1804	Target Neighborhood Hits	898	Shared Neighborhood Hits	782
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB3_HUMAN
NC score	0.637345 (rank : 753)	θ value	0.000461057 (rank : 829)
Query Neighborhood Hits	1804	Target Neighborhood Hits	918	Shared Neighborhood Hits	778
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

SCYL2_MOUSE
NC score	0.635269 (rank : 754)	θ value	0.0252991 (rank : 965)
Query Neighborhood Hits	1804	Target Neighborhood Hits	603	Shared Neighborhood Hits	550
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

ROR2_HUMAN
NC score	0.634990 (rank : 755)	θ value	1.43324e-05 (rank : 752)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1014	Shared Neighborhood Hits	792
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

TGFR1_HUMAN
NC score	0.634791 (rank : 756)	θ value	0.0113563 (rank : 920)
Query Neighborhood Hits	1804	Target Neighborhood Hits	755	Shared Neighborhood Hits	746
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.634392 (rank : 757)	θ value	0.0113563 (rank : 921)
Query Neighborhood Hits	1804	Target Neighborhood Hits	753	Shared Neighborhood Hits	746
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

RIPK4_HUMAN
NC score	0.633941 (rank : 758)	θ value	1.33837e-11 (rank : 499)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1094	Shared Neighborhood Hits	814
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

MERTK_MOUSE
NC score	0.633173 (rank : 759)	θ value	1.69304e-06 (rank : 701)
Query Neighborhood Hits	1804	Target Neighborhood Hits	974	Shared Neighborhood Hits	769
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

IRAK3_HUMAN
NC score	0.633045 (rank : 760)	θ value	4.1701e-05 (rank : 774)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	629
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ANKK1_HUMAN
NC score	0.629843 (rank : 761)	θ value	3.89403e-11 (rank : 511)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1075	Shared Neighborhood Hits	802
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

FGFR4_MOUSE
NC score	0.628593 (rank : 762)	θ value	2.44474e-05 (rank : 759)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1026	Shared Neighborhood Hits	795
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

DDR1_MOUSE
NC score	0.627398 (rank : 763)	θ value	5.81887e-07 (rank : 669)
Query Neighborhood Hits	1804	Target Neighborhood Hits	818	Shared Neighborhood Hits	768
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

MERTK_HUMAN
NC score	0.627209 (rank : 764)	θ value	4.92598e-06 (rank : 724)
Query Neighborhood Hits	1804	Target Neighborhood Hits	988	Shared Neighborhood Hits	777
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

INSRR_MOUSE
NC score	0.627144 (rank : 765)	θ value	5.44631e-05 (rank : 783)
Query Neighborhood Hits	1804	Target Neighborhood Hits	961	Shared Neighborhood Hits	782
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

DDR1_HUMAN
NC score	0.626268 (rank : 766)	θ value	9.92553e-07 (rank : 676)
Query Neighborhood Hits	1804	Target Neighborhood Hits	819	Shared Neighborhood Hits	769
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

IGF1R_MOUSE
NC score	0.624887 (rank : 767)	θ value	0.000158464 (rank : 801)
Query Neighborhood Hits	1804	Target Neighborhood Hits	973	Shared Neighborhood Hits	792
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.624716 (rank : 768)	θ value	7.1131e-05 (rank : 786)
Query Neighborhood Hits	1804	Target Neighborhood Hits	950	Shared Neighborhood Hits	785
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PTK7_HUMAN
NC score	0.624044 (rank : 769)	θ value	4.30538e-10 (rank : 539)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	782
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

IGF1R_HUMAN
NC score	0.621950 (rank : 770)	θ value	0.00035302 (rank : 819)
Query Neighborhood Hits	1804	Target Neighborhood Hits	977	Shared Neighborhood Hits	794
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IRAK3_MOUSE
NC score	0.621212 (rank : 771)	θ value	3.19293e-05 (rank : 764)
Query Neighborhood Hits	1804	Target Neighborhood Hits	628	Shared Neighborhood Hits	608
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

VGFR3_MOUSE
NC score	0.621190 (rank : 772)	θ value	3.41135e-07 (rank : 657)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1056	Shared Neighborhood Hits	794
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

ALK_HUMAN
NC score	0.619464 (rank : 773)	θ value	4.1701e-05 (rank : 772)
Query Neighborhood Hits	1804	Target Neighborhood Hits	795	Shared Neighborhood Hits	741
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

PGFRA_HUMAN
NC score	0.618404 (rank : 774)	θ value	0.00020696 (rank : 809)
Query Neighborhood Hits	1804	Target Neighborhood Hits	980	Shared Neighborhood Hits	792
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VGFR3_HUMAN
NC score	0.617914 (rank : 775)	θ value	4.45536e-07 (rank : 666)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	794
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

LTK_MOUSE
NC score	0.617860 (rank : 776)	θ value	3.41135e-07 (rank : 654)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	748
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.616964 (rank : 777)	θ value	7.1131e-05 (rank : 785)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	756
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

PGFRA_MOUSE
NC score	0.616811 (rank : 778)	θ value	0.00020696 (rank : 810)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	791
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VGFR1_MOUSE
NC score	0.616696 (rank : 779)	θ value	1.09739e-05 (rank : 747)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1118	Shared Neighborhood Hits	808
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

ACVL1_MOUSE
NC score	0.615135 (rank : 780)	θ value	0.00175202 (rank : 855)
Query Neighborhood Hits	1804	Target Neighborhood Hits	739	Shared Neighborhood Hits	732
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

VGFR2_MOUSE
NC score	0.612676 (rank : 781)	θ value	4.92598e-06 (rank : 727)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1089	Shared Neighborhood Hits	801
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA6_MOUSE
NC score	0.612150 (rank : 782)	θ value	3.41135e-07 (rank : 652)
Query Neighborhood Hits	1804	Target Neighborhood Hits	946	Shared Neighborhood Hits	807
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

PGFRB_HUMAN
NC score	0.609980 (rank : 783)	θ value	5.26297e-08 (rank : 620)
Query Neighborhood Hits	1804	Target Neighborhood Hits	962	Shared Neighborhood Hits	793
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VGFR1_HUMAN
NC score	0.609101 (rank : 784)	θ value	1.87187e-05 (rank : 757)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1109	Shared Neighborhood Hits	804
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR2_HUMAN
NC score	0.608885 (rank : 785)	θ value	4.92598e-06 (rank : 726)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	803
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

PGFRB_MOUSE
NC score	0.608677 (rank : 786)	θ value	8.97725e-08 (rank : 629)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	792
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KIT_HUMAN
NC score	0.608458 (rank : 787)	θ value	1.87187e-05 (rank : 755)
Query Neighborhood Hits	1804	Target Neighborhood Hits	953	Shared Neighborhood Hits	794
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MUSK_HUMAN
NC score	0.608190 (rank : 788)	θ value	8.67504e-11 (rank : 523)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1074	Shared Neighborhood Hits	789
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

EPHA6_HUMAN
NC score	0.607147 (rank : 789)	θ value	9.92553e-07 (rank : 678)
Query Neighborhood Hits	1804	Target Neighborhood Hits	959	Shared Neighborhood Hits	808
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ROR2_MOUSE
NC score	0.605938 (rank : 790)	θ value	9.29e-05 (rank : 793)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1000	Shared Neighborhood Hits	770
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

KIT_MOUSE
NC score	0.604995 (rank : 791)	θ value	6.43352e-06 (rank : 730)
Query Neighborhood Hits	1804	Target Neighborhood Hits	949	Shared Neighborhood Hits	794
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FLT3_HUMAN
NC score	0.604727 (rank : 792)	θ value	5.44631e-05 (rank : 782)
Query Neighborhood Hits	1804	Target Neighborhood Hits	843	Shared Neighborhood Hits	787
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

MUSK_MOUSE
NC score	0.604222 (rank : 793)	θ value	8.67504e-11 (rank : 524)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1057	Shared Neighborhood Hits	785
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

BUB1_MOUSE
NC score	0.603985 (rank : 794)	θ value	1.06291 (rank : 1284)
Query Neighborhood Hits	1804	Target Neighborhood Hits	583	Shared Neighborhood Hits	539
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

LTK_HUMAN
NC score	0.603697 (rank : 795)	θ value	0.000158464 (rank : 805)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	749
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

FLT3_MOUSE
NC score	0.601806 (rank : 796)	θ value	0.000121331 (rank : 796)
Query Neighborhood Hits	1804	Target Neighborhood Hits	847	Shared Neighborhood Hits	788
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ACVL1_HUMAN
NC score	0.592285 (rank : 797)	θ value	0.00869519 (rank : 899)
Query Neighborhood Hits	1804	Target Neighborhood Hits	716	Shared Neighborhood Hits	709
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TOPK_MOUSE
NC score	0.590518 (rank : 798)	θ value	0.279714 (rank : 1159)
Query Neighborhood Hits	1804	Target Neighborhood Hits	618	Shared Neighborhood Hits	605
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

CSF1R_HUMAN
NC score	0.576817 (rank : 799)	θ value	0.000121331 (rank : 794)
Query Neighborhood Hits	1804	Target Neighborhood Hits	943	Shared Neighborhood Hits	789
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
NC score	0.572623 (rank : 800)	θ value	0.000121331 (rank : 795)
Query Neighborhood Hits	1804	Target Neighborhood Hits	983	Shared Neighborhood Hits	787
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TOPK_HUMAN
NC score	0.572196 (rank : 801)	θ value	θ > 10 (rank : 1876)
Query Neighborhood Hits	1804	Target Neighborhood Hits	605	Shared Neighborhood Hits	593
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

RYK_MOUSE
NC score	0.562038 (rank : 802)	θ value	0.00228821 (rank : 862)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	699
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

ACV1C_MOUSE
NC score	0.561824 (rank : 803)	θ value	8.99809 (rank : 1723)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	700
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_HUMAN
NC score	0.555665 (rank : 804)	θ value	θ > 10 (rank : 1806)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	693
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MLKL_HUMAN
NC score	0.548374 (rank : 805)	θ value	0.0252991 (rank : 964)
Query Neighborhood Hits	1804	Target Neighborhood Hits	600	Shared Neighborhood Hits	576
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

EPHB6_MOUSE
NC score	0.547737 (rank : 806)	θ value	0.00665767 (rank : 890)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	732
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHAA_HUMAN
NC score	0.547659 (rank : 807)	θ value	0.0431538 (rank : 1000)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	753
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

RYK_HUMAN
NC score	0.545834 (rank : 808)	θ value	0.00665767 (rank : 895)
Query Neighborhood Hits	1804	Target Neighborhood Hits	701	Shared Neighborhood Hits	687
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

SRPK1_MOUSE
NC score	0.539150 (rank : 809)	θ value	0.0431538 (rank : 1013)
Query Neighborhood Hits	1804	Target Neighborhood Hits	639	Shared Neighborhood Hits	575
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_HUMAN
NC score	0.536734 (rank : 810)	θ value	0.0431538 (rank : 1012)
Query Neighborhood Hits	1804	Target Neighborhood Hits	706	Shared Neighborhood Hits	593
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

AMHR2_HUMAN
NC score	0.535705 (rank : 811)	θ value	0.0330416 (rank : 971)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	665
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

SRPK2_HUMAN
NC score	0.535654 (rank : 812)	θ value	0.0330416 (rank : 986)
Query Neighborhood Hits	1804	Target Neighborhood Hits	664	Shared Neighborhood Hits	584
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_MOUSE
NC score	0.533182 (rank : 813)	θ value	0.0330416 (rank : 989)
Query Neighborhood Hits	1804	Target Neighborhood Hits	572	Shared Neighborhood Hits	559
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_MOUSE
NC score	0.533133 (rank : 814)	θ value	0.0330416 (rank : 987)
Query Neighborhood Hits	1804	Target Neighborhood Hits	765	Shared Neighborhood Hits	597
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

EPHB6_HUMAN
NC score	0.533051 (rank : 815)	θ value	0.00509761 (rank : 882)
Query Neighborhood Hits	1804	Target Neighborhood Hits	912	Shared Neighborhood Hits	706
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

STK23_HUMAN
NC score	0.532304 (rank : 816)	θ value	0.0330416 (rank : 988)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	552
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

GUC2F_HUMAN
NC score	0.513475 (rank : 817)	θ value	0.0330416 (rank : 975)
Query Neighborhood Hits	1804	Target Neighborhood Hits	740	Shared Neighborhood Hits	676
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

VRK2_MOUSE
NC score	0.512646 (rank : 818)	θ value	0.0193708 (rank : 951)
Query Neighborhood Hits	1804	Target Neighborhood Hits	586	Shared Neighborhood Hits	576
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_HUMAN
NC score	0.494995 (rank : 819)	θ value	0.0252991 (rank : 970)
Query Neighborhood Hits	1804	Target Neighborhood Hits	582	Shared Neighborhood Hits	563
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

TEX14_MOUSE
NC score	0.492782 (rank : 820)	θ value	0.00035302 (rank : 825)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1333	Shared Neighborhood Hits	721
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

VRK1_HUMAN
NC score	0.479015 (rank : 821)	θ value	1.38821 (rank : 1353)
Query Neighborhood Hits	1804	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
NC score	0.477076 (rank : 822)	θ value	0.0961366 (rank : 1065)
Query Neighborhood Hits	1804	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

ANPRB_HUMAN
NC score	0.472623 (rank : 823)	θ value	0.000602161 (rank : 833)
Query Neighborhood Hits	1804	Target Neighborhood Hits	646	Shared Neighborhood Hits	583
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2C_HUMAN
NC score	0.468258 (rank : 824)	θ value	1.81305 (rank : 1369)
Query Neighborhood Hits	1804	Target Neighborhood Hits	624	Shared Neighborhood Hits	584
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
NC score	0.466413 (rank : 825)	θ value	0.0431538 (rank : 1001)
Query Neighborhood Hits	1804	Target Neighborhood Hits	715	Shared Neighborhood Hits	662
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

NRBP_HUMAN
NC score	0.455151 (rank : 826)	θ value	θ > 10 (rank : 1843)
Query Neighborhood Hits	1804	Target Neighborhood Hits	448	Shared Neighborhood Hits	423
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.452792 (rank : 827)	θ value	θ > 10 (rank : 1844)
Query Neighborhood Hits	1804	Target Neighborhood Hits	442	Shared Neighborhood Hits	417
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

TEX14_HUMAN
NC score	0.451806 (rank : 828)	θ value	0.0193708 (rank : 950)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1103	Shared Neighborhood Hits	665
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GUC2G_MOUSE
NC score	0.445805 (rank : 829)	θ value	0.0431538 (rank : 1002)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2E_MOUSE
NC score	0.442602 (rank : 830)	θ value	0.0563607 (rank : 1021)
Query Neighborhood Hits	1804	Target Neighborhood Hits	692	Shared Neighborhood Hits	638
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

ANPRB_MOUSE
NC score	0.439651 (rank : 831)	θ value	0.00298849 (rank : 863)
Query Neighborhood Hits	1804	Target Neighborhood Hits	607	Shared Neighborhood Hits	558
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_HUMAN
NC score	0.428525 (rank : 832)	θ value	0.0961366 (rank : 1048)
Query Neighborhood Hits	1804	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

BUB1_HUMAN
NC score	0.428394 (rank : 833)	θ value	8.99809 (rank : 1730)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	425
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

ANPRA_MOUSE
NC score	0.426965 (rank : 834)	θ value	0.0736092 (rank : 1029)
Query Neighborhood Hits	1804	Target Neighborhood Hits	600	Shared Neighborhood Hits	538
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ILK1_HUMAN
NC score	0.424234 (rank : 835)	θ value	θ > 10 (rank : 1833)
Query Neighborhood Hits	1804	Target Neighborhood Hits	857	Shared Neighborhood Hits	603
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.422564 (rank : 836)	θ value	8.99809 (rank : 1753)
Query Neighborhood Hits	1804	Target Neighborhood Hits	858	Shared Neighborhood Hits	604
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK2_HUMAN
NC score	0.412654 (rank : 837)	θ value	θ > 10 (rank : 1834)
Query Neighborhood Hits	1804	Target Neighborhood Hits	848	Shared Neighborhood Hits	595
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

PI3R4_MOUSE
NC score	0.391837 (rank : 838)	θ value	0.0736092 (rank : 1042)
Query Neighborhood Hits	1804	Target Neighborhood Hits	535	Shared Neighborhood Hits	367
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PI3R4_HUMAN
NC score	0.382033 (rank : 839)	θ value	0.0563607 (rank : 1025)
Query Neighborhood Hits	1804	Target Neighborhood Hits	534	Shared Neighborhood Hits	359
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

K2002_HUMAN
NC score	0.367696 (rank : 840)	θ value	0.0330416 (rank : 976)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	264
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

RN5A_MOUSE
NC score	0.337926 (rank : 841)	θ value	0.0431538 (rank : 1009)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	621
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

NTKL_MOUSE
NC score	0.328443 (rank : 842)	θ value	θ > 10 (rank : 1846)
Query Neighborhood Hits	1804	Target Neighborhood Hits	326	Shared Neighborhood Hits	294
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

STK31_HUMAN
NC score	0.327075 (rank : 843)	θ value	θ > 10 (rank : 1871)
Query Neighborhood Hits	1804	Target Neighborhood Hits	570	Shared Neighborhood Hits	385
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

K2002_MOUSE
NC score	0.309492 (rank : 844)	θ value	0.0431538 (rank : 1004)
Query Neighborhood Hits	1804	Target Neighborhood Hits	267	Shared Neighborhood Hits	238
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

VRK3_HUMAN
NC score	0.276632 (rank : 845)	θ value	5.27518 (rank : 1645)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	324
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

STK31_MOUSE
NC score	0.271357 (rank : 846)	θ value	θ > 10 (rank : 1872)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	316
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

NTKL_HUMAN
NC score	0.249170 (rank : 847)	θ value	θ > 10 (rank : 1845)
Query Neighborhood Hits	1804	Target Neighborhood Hits	266	Shared Neighborhood Hits	230
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

VRK3_MOUSE
NC score	0.245247 (rank : 848)	θ value	θ > 10 (rank : 1886)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	325
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

PXK_MOUSE
NC score	0.197929 (rank : 849)	θ value	θ > 10 (rank : 1853)
Query Neighborhood Hits	1804	Target Neighborhood Hits	320	Shared Neighborhood Hits	217
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RN5A_HUMAN
NC score	0.168215 (rank : 850)	θ value	0.163984 (rank : 1104)
Query Neighborhood Hits	1804	Target Neighborhood Hits	608	Shared Neighborhood Hits	346
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

PXK_HUMAN
NC score	0.159210 (rank : 851)	θ value	θ > 10 (rank : 1852)
Query Neighborhood Hits	1804	Target Neighborhood Hits	216	Shared Neighborhood Hits	144
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PDZD8_HUMAN
NC score	0.141142 (rank : 852)	θ value	0.279714 (rank : 1153)
Query Neighborhood Hits	1804	Target Neighborhood Hits	185	Shared Neighborhood Hits	95
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PRPK_MOUSE
NC score	0.137886 (rank : 853)	θ value	θ > 10 (rank : 1851)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	132
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

NACAM_MOUSE
NC score	0.135343 (rank : 854)	θ value	8.11959e-09 (rank : 590)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1866	Shared Neighborhood Hits	630
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PRPK_HUMAN
NC score	0.134832 (rank : 855)	θ value	θ > 10 (rank : 1850)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	128
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

SRRM1_MOUSE
NC score	0.134612 (rank : 856)	θ value	2.36244e-08 (rank : 604)
Query Neighborhood Hits	1804	Target Neighborhood Hits	966	Shared Neighborhood Hits	423
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

GRP3_HUMAN
NC score	0.134277 (rank : 857)	θ value	θ > 10 (rank : 1832)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

SRRM2_MOUSE
NC score	0.134214 (rank : 858)	θ value	9.92553e-07 (rank : 681)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1470	Shared Neighborhood Hits	525
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

PSCBP_MOUSE
NC score	0.127897 (rank : 859)	θ value	7.59969e-07 (rank : 674)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	99
SwissProt Accessions	Q91VY6, Q3TZH1, Q8R4T4, Q9QZA9	Gene names	Pscdbp
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (Cbp).

PSCBP_HUMAN
NC score	0.127000 (rank : 860)	θ value	4.45536e-07 (rank : 665)
Query Neighborhood Hits	1804	Target Neighborhood Hits	123	Shared Neighborhood Hits	101
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

GRASP_MOUSE
NC score	0.126005 (rank : 861)	θ value	8.40245e-06 (rank : 735)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JJA9, Q9JKL0	Gene names	Grasp
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

GRASP_HUMAN
NC score	0.125439 (rank : 862)	θ value	8.40245e-06 (rank : 734)
Query Neighborhood Hits	1804	Target Neighborhood Hits	147	Shared Neighborhood Hits	112
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

SRRM2_HUMAN
NC score	0.123995 (rank : 863)	θ value	2.52405e-10 (rank : 534)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1296	Shared Neighborhood Hits	472
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PDZD1_MOUSE
NC score	0.118462 (rank : 864)	θ value	1.25267e-09 (rank : 554)
Query Neighborhood Hits	1804	Target Neighborhood Hits	191	Shared Neighborhood Hits	120
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PCLO_HUMAN
NC score	0.116127 (rank : 865)	θ value	4.92598e-06 (rank : 725)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2046	Shared Neighborhood Hits	618
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
NC score	0.115643 (rank : 866)	θ value	1.63604e-09 (rank : 560)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2275	Shared Neighborhood Hits	705
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

BSN_MOUSE
NC score	0.114549 (rank : 867)	θ value	0.00175202 (rank : 856)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2057	Shared Neighborhood Hits	642
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

MUC1_HUMAN
NC score	0.114271 (rank : 868)	θ value	1.42992e-13 (rank : 444)
Query Neighborhood Hits	1804	Target Neighborhood Hits	975	Shared Neighborhood Hits	407
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

PDZD1_HUMAN
NC score	0.114270 (rank : 869)	θ value	1.63604e-09 (rank : 561)
Query Neighborhood Hits	1804	Target Neighborhood Hits	190	Shared Neighborhood Hits	120
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

SRRM1_HUMAN
NC score	0.112294 (rank : 870)	θ value	2.36244e-08 (rank : 603)
Query Neighborhood Hits	1804	Target Neighborhood Hits	690	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

MDC1_HUMAN
NC score	0.111100 (rank : 871)	θ value	0.0252991 (rank : 963)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1446	Shared Neighborhood Hits	501
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

STAC_MOUSE
NC score	0.109251 (rank : 872)	θ value	θ > 10 (rank : 1870)
Query Neighborhood Hits	1804	Target Neighborhood Hits	268	Shared Neighborhood Hits	102
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

RASF1_MOUSE
NC score	0.108259 (rank : 873)	θ value	θ > 10 (rank : 1856)
Query Neighborhood Hits	1804	Target Neighborhood Hits	74	Shared Neighborhood Hits	36
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

MDC1_MOUSE
NC score	0.108177 (rank : 874)	θ value	0.00869519 (rank : 903)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	427
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

UN13A_HUMAN
NC score	0.106157 (rank : 875)	θ value	θ > 10 (rank : 1877)
Query Neighborhood Hits	1804	Target Neighborhood Hits	285	Shared Neighborhood Hits	77
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

PDZD3_MOUSE
NC score	0.104048 (rank : 876)	θ value	1.43324e-05 (rank : 751)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	117
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

OGFR_HUMAN
NC score	0.104046 (rank : 877)	θ value	0.00298849 (rank : 868)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1582	Shared Neighborhood Hits	576
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

STAC_HUMAN
NC score	0.103177 (rank : 878)	θ value	θ > 10 (rank : 1869)
Query Neighborhood Hits	1804	Target Neighborhood Hits	276	Shared Neighborhood Hits	104
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

UN13B_HUMAN
NC score	0.102739 (rank : 879)	θ value	θ > 10 (rank : 1878)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

STAC3_MOUSE
NC score	0.102369 (rank : 880)	θ value	θ > 10 (rank : 1868)
Query Neighborhood Hits	1804	Target Neighborhood Hits	232	Shared Neighborhood Hits	86
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PDZD3_HUMAN
NC score	0.101824 (rank : 881)	θ value	7.1131e-05 (rank : 790)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	123
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

TARA_HUMAN
NC score	0.100731 (rank : 882)	θ value	1.09739e-05 (rank : 746)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1626	Shared Neighborhood Hits	483
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

STAC3_HUMAN
NC score	0.100730 (rank : 883)	θ value	θ > 10 (rank : 1867)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	88
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NHRF2_HUMAN
NC score	0.100427 (rank : 884)	θ value	0.00228821 (rank : 861)
Query Neighborhood Hits	1804	Target Neighborhood Hits	197	Shared Neighborhood Hits	125
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

NHRF2_MOUSE
NC score	0.099987 (rank : 885)	θ value	0.00390308 (rank : 875)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	128
SwissProt Accessions	Q9JHL1, Q3TDR3, Q8BGL9, Q8BW05, Q9DCR6	Gene names	Slc9a3r2, Nherf2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2) (Octs2).

UN13B_MOUSE
NC score	0.099778 (rank : 886)	θ value	θ > 10 (rank : 1879)
Query Neighborhood Hits	1804	Target Neighborhood Hits	210	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SHAN2_HUMAN
NC score	0.099753 (rank : 887)	θ value	0.00665767 (rank : 896)
Query Neighborhood Hits	1804	Target Neighborhood Hits	346	Shared Neighborhood Hits	209
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

DGKD_HUMAN
NC score	0.099532 (rank : 888)	θ value	θ > 10 (rank : 1820)
Query Neighborhood Hits	1804	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

SHAN2_MOUSE
NC score	0.098770 (rank : 889)	θ value	0.00665767 (rank : 897)
Query Neighborhood Hits	1804	Target Neighborhood Hits	446	Shared Neighborhood Hits	216
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

BSN_HUMAN
NC score	0.098142 (rank : 890)	θ value	0.0148317 (rank : 926)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1537	Shared Neighborhood Hits	499
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BUB1B_HUMAN
NC score	0.097828 (rank : 891)	θ value	θ > 10 (rank : 1808)
Query Neighborhood Hits	1804	Target Neighborhood Hits	208	Shared Neighborhood Hits	124
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

PRRT3_HUMAN
NC score	0.097670 (rank : 892)	θ value	0.279714 (rank : 1155)
Query Neighborhood Hits	1804	Target Neighborhood Hits	998	Shared Neighborhood Hits	427
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

DGKQ_HUMAN
NC score	0.097567 (rank : 893)	θ value	θ > 10 (rank : 1825)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	47
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

CHIO_HUMAN
NC score	0.097444 (rank : 894)	θ value	θ > 10 (rank : 1812)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	75
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TGON2_HUMAN
NC score	0.097415 (rank : 895)	θ value	0.0330416 (rank : 991)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1037	Shared Neighborhood Hits	389
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

RGS3_MOUSE
NC score	0.097038 (rank : 896)	θ value	0.21417 (rank : 1132)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1621	Shared Neighborhood Hits	618
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

NHERF_MOUSE
NC score	0.096861 (rank : 897)	θ value	0.00102713 (rank : 840)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	127
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

CHIN_MOUSE
NC score	0.096570 (rank : 898)	θ value	θ > 10 (rank : 1811)
Query Neighborhood Hits	1804	Target Neighborhood Hits	229	Shared Neighborhood Hits	77
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
NC score	0.095663 (rank : 899)	θ value	θ > 10 (rank : 1810)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	75
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DGKH_HUMAN
NC score	0.094388 (rank : 900)	θ value	θ > 10 (rank : 1823)
Query Neighborhood Hits	1804	Target Neighborhood Hits	255	Shared Neighborhood Hits	88
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

NCOA6_HUMAN
NC score	0.094314 (rank : 901)	θ value	0.163984 (rank : 1098)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1202	Shared Neighborhood Hits	475
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NFH_MOUSE
NC score	0.093566 (rank : 902)	θ value	5.26297e-08 (rank : 619)
Query Neighborhood Hits	1804	Target Neighborhood Hits	2247	Shared Neighborhood Hits	678
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NHERF_HUMAN
NC score	0.093108 (rank : 903)	θ value	0.00228821 (rank : 860)
Query Neighborhood Hits	1804	Target Neighborhood Hits	190	Shared Neighborhood Hits	127
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

RGS3_HUMAN
NC score	0.092820 (rank : 904)	θ value	θ > 10 (rank : 1858)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1375	Shared Neighborhood Hits	541
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CHIO_MOUSE
NC score	0.092631 (rank : 905)	θ value	θ > 10 (rank : 1813)
Query Neighborhood Hits	1804	Target Neighborhood Hits	130	Shared Neighborhood Hits	48
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

GRIN1_HUMAN
NC score	0.092210 (rank : 906)	θ value	0.00134147 (rank : 846)
Query Neighborhood Hits	1804	Target Neighborhood Hits	681	Shared Neighborhood Hits	294
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

PDZD2_HUMAN
NC score	0.091682 (rank : 907)	θ value	0.163984 (rank : 1100)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	372
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

BAT2_HUMAN
NC score	0.091477 (rank : 908)	θ value	4.92598e-06 (rank : 719)
Query Neighborhood Hits	1804	Target Neighborhood Hits	931	Shared Neighborhood Hits	403
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

MAGI1_HUMAN
NC score	0.089309 (rank : 909)	θ value	0.000270298 (rank : 815)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	181
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

RASF1_HUMAN
NC score	0.088726 (rank : 910)	θ value	θ > 10 (rank : 1855)
Query Neighborhood Hits	1804	Target Neighborhood Hits	62	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

MAGI1_MOUSE
NC score	0.087164 (rank : 911)	θ value	0.000158464 (rank : 806)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	187
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

SON_HUMAN
NC score	0.087119 (rank : 912)	θ value	1.06291 (rank : 1306)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1568	Shared Neighborhood Hits	516
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NCOA6_MOUSE
NC score	0.086340 (rank : 913)	θ value	0.00298849 (rank : 867)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1076	Shared Neighborhood Hits	412
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SLAP2_MOUSE
NC score	0.086284 (rank : 914)	θ value	θ > 10 (rank : 1866)
Query Neighborhood Hits	1804	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

TARSH_HUMAN
NC score	0.086260 (rank : 915)	θ value	θ > 10 (rank : 1875)
Query Neighborhood Hits	1804	Target Neighborhood Hits	768	Shared Neighborhood Hits	339
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TXND2_HUMAN
NC score	0.085927 (rank : 916)	θ value	0.21417 (rank : 1136)
Query Neighborhood Hits	1804	Target Neighborhood Hits	793	Shared Neighborhood Hits	301
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

MAGI2_HUMAN
NC score	0.085679 (rank : 917)	θ value	4.1701e-05 (rank : 775)
Query Neighborhood Hits	1804	Target Neighborhood Hits	373	Shared Neighborhood Hits	191
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SHAN1_HUMAN
NC score	0.083704 (rank : 918)	θ value	0.000786445 (rank : 838)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1041	Shared Neighborhood Hits	366
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

MAGI2_MOUSE
NC score	0.083590 (rank : 919)	θ value	0.000121331 (rank : 797)
Query Neighborhood Hits	1804	Target Neighborhood Hits	370	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

SLAP2_HUMAN
NC score	0.083577 (rank : 920)	θ value	θ > 10 (rank : 1865)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

WHRN_MOUSE
NC score	0.083343 (rank : 921)	θ value	0.000602161 (rank : 835)
Query Neighborhood Hits	1804	Target Neighborhood Hits	412	Shared Neighborhood Hits	217
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

SLAP1_HUMAN
NC score	0.082809 (rank : 922)	θ value	θ > 10 (rank : 1863)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	42
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PRB4S_HUMAN
NC score	0.082719 (rank : 923)	θ value	0.00134147 (rank : 851)
Query Neighborhood Hits	1804	Target Neighborhood Hits	330	Shared Neighborhood Hits	157
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRG4_HUMAN
NC score	0.082344 (rank : 924)	θ value	3.29651e-10 (rank : 535)
Query Neighborhood Hits	1804	Target Neighborhood Hits	764	Shared Neighborhood Hits	262
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

BAT2_MOUSE
NC score	0.082127 (rank : 925)	θ value	2.44474e-05 (rank : 758)
Query Neighborhood Hits	1804	Target Neighborhood Hits	947	Shared Neighborhood Hits	397
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

NCOR2_HUMAN
NC score	0.082031 (rank : 926)	θ value	2.13673e-09 (rank : 564)
Query Neighborhood Hits	1804	Target Neighborhood Hits	870	Shared Neighborhood Hits	308
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

VAV_HUMAN
NC score	0.082019 (rank : 927)	θ value	θ > 10 (rank : 1884)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	117
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

RHPN1_MOUSE
NC score	0.081707 (rank : 928)	θ value	0.00665767 (rank : 894)
Query Neighborhood Hits	1804	Target Neighborhood Hits	154	Shared Neighborhood Hits	113
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

SLAP1_MOUSE
NC score	0.081490 (rank : 929)	θ value	θ > 10 (rank : 1864)
Query Neighborhood Hits	1804	Target Neighborhood Hits	117	Shared Neighborhood Hits	43
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BUB1B_MOUSE
NC score	0.080113 (rank : 930)	θ value	θ > 10 (rank : 1809)
Query Neighborhood Hits	1804	Target Neighborhood Hits	202	Shared Neighborhood Hits	133
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

VAV3_HUMAN
NC score	0.079628 (rank : 931)	θ value	θ > 10 (rank : 1882)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_HUMAN
NC score	0.079363 (rank : 932)	θ value	θ > 10 (rank : 1880)
Query Neighborhood Hits	1804	Target Neighborhood Hits	453	Shared Neighborhood Hits	123
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BASP_MOUSE
NC score	0.079050 (rank : 933)	θ value	0.00665767 (rank : 888)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	128
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

VAV3_MOUSE
NC score	0.078732 (rank : 934)	θ value	θ > 10 (rank : 1883)
Query Neighborhood Hits	1804	Target Neighborhood Hits	404	Shared Neighborhood Hits	115
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

PRG4_MOUSE
NC score	0.078205 (rank : 935)	θ value	1.74796e-11 (rank : 502)
Query Neighborhood Hits	1804	Target Neighborhood Hits	624	Shared Neighborhood Hits	225
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRP1_HUMAN
NC score	0.078198 (rank : 936)	θ value	0.00134147 (rank : 852)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	179
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

WASIP_HUMAN
NC score	0.078066 (rank : 937)	θ value	0.0193708 (rank : 952)
Query Neighborhood Hits	1804	Target Neighborhood Hits	458	Shared Neighborhood Hits	202
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

VAV_MOUSE
NC score	0.077826 (rank : 938)	θ value	θ > 10 (rank : 1885)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	115
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.077332 (rank : 939)	θ value	θ > 10 (rank : 1881)
Query Neighborhood Hits	1804	Target Neighborhood Hits	456	Shared Neighborhood Hits	128
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ATN1_HUMAN
NC score	0.077235 (rank : 940)	θ value	0.000602161 (rank : 834)
Query Neighborhood Hits	1804	Target Neighborhood Hits	676	Shared Neighborhood Hits	245
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

TCOF_MOUSE
NC score	0.077109 (rank : 941)	θ value	0.00035302 (rank : 824)
Query Neighborhood Hits	1804	Target Neighborhood Hits	471	Shared Neighborhood Hits	188
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

DGKB_HUMAN
NC score	0.076371 (rank : 942)	θ value	θ > 10 (rank : 1819)
Query Neighborhood Hits	1804	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

LCP2_HUMAN
NC score	0.075975 (rank : 943)	θ value	0.62314 (rank : 1242)
Query Neighborhood Hits	1804	Target Neighborhood Hits	531	Shared Neighborhood Hits	251
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TAU_MOUSE
NC score	0.075108 (rank : 944)	θ value	0.0961366 (rank : 1062)
Query Neighborhood Hits	1804	Target Neighborhood Hits	502	Shared Neighborhood Hits	242
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

USH1C_MOUSE
NC score	0.075077 (rank : 945)	θ value	0.47712 (rank : 1216)
Query Neighborhood Hits	1804	Target Neighborhood Hits	557	Shared Neighborhood Hits	208
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

GSCR1_HUMAN
NC score	0.075074 (rank : 946)	θ value	2.88788e-06 (rank : 708)
Query Neighborhood Hits	1804	Target Neighborhood Hits	674	Shared Neighborhood Hits	257
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

WHRN_HUMAN
NC score	0.074782 (rank : 947)	θ value	0.0113563 (rank : 922)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	179
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

MAGE1_HUMAN
NC score	0.074431 (rank : 948)	θ value	0.0736092 (rank : 1037)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1389	Shared Neighborhood Hits	493
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

LAD1_HUMAN
NC score	0.074061 (rank : 949)	θ value	0.62314 (rank : 1240)
Query Neighborhood Hits	1804	Target Neighborhood Hits	441	Shared Neighborhood Hits	197
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MLL3_HUMAN
NC score	0.073656 (rank : 950)	θ value	9.29e-05 (rank : 792)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1644	Shared Neighborhood Hits	492
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DGKG_MOUSE
NC score	0.072927 (rank : 951)	θ value	θ > 10 (rank : 1822)
Query Neighborhood Hits	1804	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

MBB1A_HUMAN
NC score	0.072837 (rank : 952)	θ value	0.125558 (rank : 1072)
Query Neighborhood Hits	1804	Target Neighborhood Hits	665	Shared Neighborhood Hits	301
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

PRB3_HUMAN
NC score	0.072470 (rank : 953)	θ value	0.0736092 (rank : 1043)
Query Neighborhood Hits	1804	Target Neighborhood Hits	318	Shared Neighborhood Hits	145
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

TCOF_HUMAN
NC score	0.072264 (rank : 954)	θ value	0.000121331 (rank : 800)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	211
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

USH1C_HUMAN
NC score	0.072155 (rank : 955)	θ value	0.47712 (rank : 1215)
Query Neighborhood Hits	1804	Target Neighborhood Hits	327	Shared Neighborhood Hits	147
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDZD7_HUMAN
NC score	0.072014 (rank : 956)	θ value	0.0736092 (rank : 1040)
Query Neighborhood Hits	1804	Target Neighborhood Hits	181	Shared Neighborhood Hits	127
SwissProt Accessions	Q9H5P4, Q8N321	Gene names	PDZD7, PDZK7
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 7.

APXL_HUMAN
NC score	0.071695 (rank : 957)	θ value	0.62314 (rank : 1223)
Query Neighborhood Hits	1804	Target Neighborhood Hits	553	Shared Neighborhood Hits	248
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

LAD1_MOUSE
NC score	0.070976 (rank : 958)	θ value	0.62314 (rank : 1241)
Query Neighborhood Hits	1804	Target Neighborhood Hits	391	Shared Neighborhood Hits	182
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

BCL9_HUMAN
NC score	0.070740 (rank : 959)	θ value	1.06291 (rank : 1282)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1008	Shared Neighborhood Hits	390
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

NOLC1_HUMAN
NC score	0.070556 (rank : 960)	θ value	7.1131e-05 (rank : 789)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	187
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

DCX_HUMAN
NC score	0.070504 (rank : 961)	θ value	5.27518 (rank : 1590)
Query Neighborhood Hits	1804	Target Neighborhood Hits	141	Shared Neighborhood Hits	76
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

INADL_MOUSE
NC score	0.070448 (rank : 962)	θ value	0.0431538 (rank : 1003)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	155
SwissProt Accessions	Q63ZW7, O70471, Q5PRG3, Q6P6J1, Q80YR8, Q8BPB9	Gene names	Inadl, Cipp, Patj
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) (Channel-interacting PDZ domain-containing protein).

SELPL_MOUSE
NC score	0.070018 (rank : 963)	θ value	6.88961 (rank : 1707)
Query Neighborhood Hits	1804	Target Neighborhood Hits	588	Shared Neighborhood Hits	269
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MINT_MOUSE
NC score	0.069682 (rank : 964)	θ value	0.00020696 (rank : 808)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1514	Shared Neighborhood Hits	457
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

WASIP_MOUSE
NC score	0.069666 (rank : 965)	θ value	0.0193708 (rank : 953)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	184
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

BASP_HUMAN
NC score	0.069378 (rank : 966)	θ value	0.0193708 (rank : 941)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	132
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CN155_HUMAN
NC score	0.069132 (rank : 967)	θ value	1.29631e-06 (rank : 684)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	150
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

MPDZ_MOUSE
NC score	0.069079 (rank : 968)	θ value	0.00134147 (rank : 849)
Query Neighborhood Hits	1804	Target Neighborhood Hits	298	Shared Neighborhood Hits	153
SwissProt Accessions	Q8VBX6, O08783, Q6P7U4, Q80ZY8, Q8BKJ1, Q8C0H8, Q8VBV5, Q8VBY0, Q9Z1K3	Gene names	Mpdz, Mupp1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ domain protein 1).

MAP1A_HUMAN
NC score	0.068919 (rank : 969)	θ value	0.163984 (rank : 1097)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1626	Shared Neighborhood Hits	429
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NIPBL_HUMAN
NC score	0.068774 (rank : 970)	θ value	5.27518 (rank : 1616)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1311	Shared Neighborhood Hits	391
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

TARA_MOUSE
NC score	0.068492 (rank : 971)	θ value	0.00390308 (rank : 879)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1133	Shared Neighborhood Hits	322
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PRP2_MOUSE
NC score	0.068490 (rank : 972)	θ value	0.125558 (rank : 1078)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	150
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

RIOK2_MOUSE
NC score	0.068415 (rank : 973)	θ value	3.0926 (rank : 1487)
Query Neighborhood Hits	1804	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

PACE1_MOUSE
NC score	0.068395 (rank : 974)	θ value	θ > 10 (rank : 1849)
Query Neighborhood Hits	1804	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

FYB_HUMAN
NC score	0.068264 (rank : 975)	θ value	5.81887e-07 (rank : 670)
Query Neighborhood Hits	1804	Target Neighborhood Hits	379	Shared Neighborhood Hits	182
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

YLPM1_HUMAN
NC score	0.068095 (rank : 976)	θ value	0.00175202 (rank : 858)
Query Neighborhood Hits	1804	Target Neighborhood Hits	670	Shared Neighborhood Hits	258
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

DGKG_HUMAN
NC score	0.068030 (rank : 977)	θ value	θ > 10 (rank : 1821)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	41
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

AFF1_HUMAN
NC score	0.067944 (rank : 978)	θ value	4.45536e-07 (rank : 658)
Query Neighborhood Hits	1804	Target Neighborhood Hits	506	Shared Neighborhood Hits	210
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

MPDZ_HUMAN
NC score	0.067930 (rank : 979)	θ value	0.00134147 (rank : 848)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	134
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

DCX_MOUSE
NC score	0.067424 (rank : 980)	θ value	3.0926 (rank : 1462)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	64
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

MARCS_HUMAN
NC score	0.067323 (rank : 981)	θ value	0.00134147 (rank : 847)
Query Neighborhood Hits	1804	Target Neighborhood Hits	204	Shared Neighborhood Hits	101
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

MUC7_HUMAN
NC score	0.067298 (rank : 982)	θ value	0.47712 (rank : 1202)
Query Neighborhood Hits	1804	Target Neighborhood Hits	538	Shared Neighborhood Hits	213
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MLL3_MOUSE
NC score	0.067242 (rank : 983)	θ value	0.125558 (rank : 1073)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1399	Shared Neighborhood Hits	413
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CJ012_HUMAN
NC score	0.067125 (rank : 984)	θ value	0.0252991 (rank : 960)
Query Neighborhood Hits	1804	Target Neighborhood Hits	467	Shared Neighborhood Hits	194
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

MLL2_HUMAN
NC score	0.067099 (rank : 985)	θ value	1.69304e-06 (rank : 702)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1788	Shared Neighborhood Hits	484
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RHPN1_HUMAN
NC score	0.067098 (rank : 986)	θ value	0.00665767 (rank : 893)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TX1B3_HUMAN
NC score	0.066983 (rank : 987)	θ value	1.06291 (rank : 1313)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	110
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

ARHGB_HUMAN
NC score	0.066713 (rank : 988)	θ value	4.1701e-05 (rank : 773)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	168
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

TX1B3_MOUSE
NC score	0.066657 (rank : 989)	θ value	1.06291 (rank : 1314)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	109
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

CSKI1_MOUSE
NC score	0.066569 (rank : 990)	θ value	1.29631e-06 (rank : 685)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1031	Shared Neighborhood Hits	362
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

GRAP_HUMAN
NC score	0.066103 (rank : 991)	θ value	θ > 10 (rank : 1828)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

CBP_MOUSE
NC score	0.066071 (rank : 992)	θ value	0.00869519 (rank : 901)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1051	Shared Neighborhood Hits	392
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

ANK2_HUMAN
NC score	0.065952 (rank : 993)	θ value	0.00665767 (rank : 886)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1615	Shared Neighborhood Hits	498
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CSKI1_HUMAN
NC score	0.065860 (rank : 994)	θ value	0.000270298 (rank : 813)
Query Neighborhood Hits	1804	Target Neighborhood Hits	997	Shared Neighborhood Hits	340
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

PACE1_HUMAN
NC score	0.065238 (rank : 995)	θ value	θ > 10 (rank : 1848)
Query Neighborhood Hits	1804	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

ASPP1_MOUSE
NC score	0.065217 (rank : 996)	θ value	8.99809 (rank : 1728)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1244	Shared Neighborhood Hits	370
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SYJ2B_HUMAN
NC score	0.065196 (rank : 997)	θ value	0.163984 (rank : 1109)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	111
SwissProt Accessions	P57105, Q96IA4	Gene names	SYNJ2BP, OMP25
Domain Architecture
Description	Synaptojanin-2-binding protein (Mitochondrial outer membrane protein 25).

WIRE_HUMAN
NC score	0.065183 (rank : 998)	θ value	0.00102713 (rank : 843)
Query Neighborhood Hits	1804	Target Neighborhood Hits	329	Shared Neighborhood Hits	153
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

MUC1_MOUSE
NC score	0.065152 (rank : 999)	θ value	0.00298849 (rank : 866)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	145
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

GRAP_MOUSE
NC score	0.065115 (rank : 1000)	θ value	θ > 10 (rank : 1829)
Query Neighborhood Hits	1804	Target Neighborhood Hits	309	Shared Neighborhood Hits	93
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCOR2_MOUSE
NC score	0.064798 (rank : 1001)	θ value	0.000786445 (rank : 836)
Query Neighborhood Hits	1804	Target Neighborhood Hits	790	Shared Neighborhood Hits	246
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NPBL_MOUSE
NC score	0.064713 (rank : 1002)	θ value	0.125558 (rank : 1074)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1041	Shared Neighborhood Hits	332
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

RP1L1_HUMAN
NC score	0.064677 (rank : 1003)	θ value	0.0330416 (rank : 983)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1072	Shared Neighborhood Hits	332
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

GRIN1_MOUSE
NC score	0.064577 (rank : 1004)	θ value	0.0563607 (rank : 1020)
Query Neighborhood Hits	1804	Target Neighborhood Hits	337	Shared Neighborhood Hits	170
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

IWS1_HUMAN
NC score	0.064555 (rank : 1005)	θ value	0.0736092 (rank : 1035)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1241	Shared Neighborhood Hits	361
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MAP4_MOUSE
NC score	0.064292 (rank : 1006)	θ value	0.0431538 (rank : 1005)
Query Neighborhood Hits	1804	Target Neighborhood Hits	409	Shared Neighborhood Hits	189
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

ENAH_MOUSE
NC score	0.063855 (rank : 1007)	θ value	0.00134147 (rank : 845)
Query Neighborhood Hits	1804	Target Neighborhood Hits	919	Shared Neighborhood Hits	256
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

IWS1_MOUSE
NC score	0.063822 (rank : 1008)	θ value	0.00869519 (rank : 902)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1258	Shared Neighborhood Hits	364
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

INADL_HUMAN
NC score	0.063603 (rank : 1009)	θ value	0.00509761 (rank : 883)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	134
SwissProt Accessions	Q8NI35, O15249, O43742, O60833, Q5VUA5, Q5VUA6, Q5VUA7, Q5VUA8, Q5VUA9, Q5VUB0, Q8WU78, Q9H3N9	Gene names	INADL, PATJ
Domain Architecture	No domain graphic available
Description	InaD-like protein (Inadl protein) (hINADL) (Pals1-associated tight junction protein) (Protein associated to tight junctions).

GRIP2_HUMAN
NC score	0.063367 (rank : 1010)	θ value	0.47712 (rank : 1198)
Query Neighborhood Hits	1804	Target Neighborhood Hits	256	Shared Neighborhood Hits	144
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

GRB2_HUMAN
NC score	0.063322 (rank : 1011)	θ value	θ > 10 (rank : 1830)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	89
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.063245 (rank : 1012)	θ value	θ > 10 (rank : 1831)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	89
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRIP1_HUMAN
NC score	0.063158 (rank : 1013)	θ value	0.163984 (rank : 1092)
Query Neighborhood Hits	1804	Target Neighborhood Hits	231	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y3R0	Gene names	GRIP1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

BAG3_MOUSE
NC score	0.063089 (rank : 1014)	θ value	0.0148317 (rank : 925)
Query Neighborhood Hits	1804	Target Neighborhood Hits	513	Shared Neighborhood Hits	247
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

RERE_MOUSE
NC score	0.062937 (rank : 1015)	θ value	2.21117e-06 (rank : 705)
Query Neighborhood Hits	1804	Target Neighborhood Hits	785	Shared Neighborhood Hits	269
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

MARCS_MOUSE
NC score	0.062870 (rank : 1016)	θ value	0.0252991 (rank : 961)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	102
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

FA47A_HUMAN
NC score	0.062771 (rank : 1017)	θ value	4.03905 (rank : 1515)
Query Neighborhood Hits	1804	Target Neighborhood Hits	451	Shared Neighborhood Hits	215
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

K1543_MOUSE
NC score	0.062710 (rank : 1018)	θ value	0.0961366 (rank : 1055)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	229
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

GRAP2_HUMAN
NC score	0.062630 (rank : 1019)	θ value	θ > 10 (rank : 1826)
Query Neighborhood Hits	1804	Target Neighborhood Hits	304	Shared Neighborhood Hits	89
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PCQAP_HUMAN
NC score	0.062229 (rank : 1020)	θ value	0.0330416 (rank : 978)
Query Neighborhood Hits	1804	Target Neighborhood Hits	549	Shared Neighborhood Hits	180
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

TAU_HUMAN
NC score	0.062040 (rank : 1021)	θ value	0.00134147 (rank : 854)
Query Neighborhood Hits	1804	Target Neighborhood Hits	448	Shared Neighborhood Hits	217
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

PRR12_HUMAN
NC score	0.061789 (rank : 1022)	θ value	0.163984 (rank : 1102)
Query Neighborhood Hits	1804	Target Neighborhood Hits	460	Shared Neighborhood Hits	188
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

IASPP_MOUSE
NC score	0.061788 (rank : 1023)	θ value	1.38821 (rank : 1331)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1024	Shared Neighborhood Hits	354
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MBD6_HUMAN
NC score	0.061637 (rank : 1024)	θ value	0.0961366 (rank : 1056)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	159
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

K1802_MOUSE
NC score	0.061547 (rank : 1025)	θ value	0.00035302 (rank : 820)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1596	Shared Neighborhood Hits	435
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MAP4_HUMAN
NC score	0.061513 (rank : 1026)	θ value	θ > 10 (rank : 1840)
Query Neighborhood Hits	1804	Target Neighborhood Hits	428	Shared Neighborhood Hits	199
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

GRAP2_MOUSE
NC score	0.061419 (rank : 1027)	θ value	θ > 10 (rank : 1827)
Query Neighborhood Hits	1804	Target Neighborhood Hits	297	Shared Neighborhood Hits	84
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

DIDO1_HUMAN
NC score	0.061308 (rank : 1028)	θ value	0.0961366 (rank : 1052)
Query Neighborhood Hits	1804	Target Neighborhood Hits	960	Shared Neighborhood Hits	334
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DOT1L_HUMAN
NC score	0.061284 (rank : 1029)	θ value	1.81305 (rank : 1366)
Query Neighborhood Hits	1804	Target Neighborhood Hits	660	Shared Neighborhood Hits	230
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

CNOT3_MOUSE
NC score	0.061277 (rank : 1030)	θ value	0.00509761 (rank : 881)
Query Neighborhood Hits	1804	Target Neighborhood Hits	504	Shared Neighborhood Hits	166
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

SON_MOUSE
NC score	0.061167 (rank : 1031)	θ value	8.99809 (rank : 1789)
Query Neighborhood Hits	1804	Target Neighborhood Hits	957	Shared Neighborhood Hits	345
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

CT151_HUMAN
NC score	0.061137 (rank : 1032)	θ value	0.00175202 (rank : 857)
Query Neighborhood Hits	1804	Target Neighborhood Hits	382	Shared Neighborhood Hits	134
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

CK024_HUMAN
NC score	0.060958 (rank : 1033)	θ value	θ > 10 (rank : 1814)
Query Neighborhood Hits	1804	Target Neighborhood Hits	408	Shared Neighborhood Hits	199
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

GRIP1_MOUSE
NC score	0.060929 (rank : 1034)	θ value	0.163984 (rank : 1093)
Query Neighborhood Hits	1804	Target Neighborhood Hits	241	Shared Neighborhood Hits	140
SwissProt Accessions	Q925T6, Q8BLQ3, Q8C0T3, Q925T5, Q925T7	Gene names	Grip1
Domain Architecture
Description	Glutamate receptor-interacting protein 1 (GRIP1 protein).

KI67_HUMAN
NC score	0.060840 (rank : 1035)	θ value	3.0926 (rank : 1469)
Query Neighborhood Hits	1804	Target Neighborhood Hits	581	Shared Neighborhood Hits	201
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

AFF1_MOUSE
NC score	0.060780 (rank : 1036)	θ value	1.43324e-05 (rank : 748)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	152
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

SYP2L_HUMAN
NC score	0.060773 (rank : 1037)	θ value	4.03905 (rank : 1560)
Query Neighborhood Hits	1804	Target Neighborhood Hits	400	Shared Neighborhood Hits	237
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

APBA3_HUMAN
NC score	0.060683 (rank : 1038)	θ value	0.0193708 (rank : 939)
Query Neighborhood Hits	1804	Target Neighborhood Hits	201	Shared Neighborhood Hits	116
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

PI5PA_HUMAN
NC score	0.060627 (rank : 1039)	θ value	1.81305 (rank : 1385)
Query Neighborhood Hits	1804	Target Neighborhood Hits	749	Shared Neighborhood Hits	325
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PDLI2_HUMAN
NC score	0.060354 (rank : 1040)	θ value	0.365318 (rank : 1180)
Query Neighborhood Hits	1804	Target Neighborhood Hits	245	Shared Neighborhood Hits	113
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

RERE_HUMAN
NC score	0.060320 (rank : 1041)	θ value	0.00035302 (rank : 821)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	269
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SYNJ1_MOUSE
NC score	0.060020 (rank : 1042)	θ value	1.53129e-07 (rank : 640)
Query Neighborhood Hits	1804	Target Neighborhood Hits	516	Shared Neighborhood Hits	223
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SC24C_HUMAN
NC score	0.059988 (rank : 1043)	θ value	0.000270298 (rank : 816)
Query Neighborhood Hits	1804	Target Neighborhood Hits	662	Shared Neighborhood Hits	273
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

TP53B_MOUSE
NC score	0.059933 (rank : 1044)	θ value	0.47712 (rank : 1213)
Query Neighborhood Hits	1804	Target Neighborhood Hits	644	Shared Neighborhood Hits	247
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

NCK2_HUMAN
NC score	0.059698 (rank : 1045)	θ value	θ > 10 (rank : 1842)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	82
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GTSE1_HUMAN
NC score	0.059639 (rank : 1046)	θ value	0.0113563 (rank : 916)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

RBBP6_MOUSE
NC score	0.059617 (rank : 1047)	θ value	0.279714 (rank : 1156)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1014	Shared Neighborhood Hits	262
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

NCK1_HUMAN
NC score	0.059565 (rank : 1048)	θ value	θ > 10 (rank : 1841)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	88
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SNPC4_HUMAN
NC score	0.059327 (rank : 1049)	θ value	0.0961366 (rank : 1059)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	261
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

WIRE_MOUSE
NC score	0.059231 (rank : 1050)	θ value	0.0431538 (rank : 1016)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	145
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

DCC_MOUSE
NC score	0.058968 (rank : 1051)	θ value	θ > 10 (rank : 1817)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	289
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

TAF4_HUMAN
NC score	0.058921 (rank : 1052)	θ value	θ > 10 (rank : 1874)
Query Neighborhood Hits	1804	Target Neighborhood Hits	687	Shared Neighborhood Hits	229
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

RASA1_HUMAN
NC score	0.058681 (rank : 1053)	θ value	θ > 10 (rank : 1854)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	73
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

CABIN_HUMAN
NC score	0.058663 (rank : 1054)	θ value	0.0193708 (rank : 942)
Query Neighborhood Hits	1804	Target Neighborhood Hits	490	Shared Neighborhood Hits	227
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

MILK1_MOUSE
NC score	0.058505 (rank : 1055)	θ value	7.1131e-05 (rank : 788)
Query Neighborhood Hits	1804	Target Neighborhood Hits	788	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SH21B_MOUSE
NC score	0.058466 (rank : 1056)	θ value	θ > 10 (rank : 1862)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

AFAD_HUMAN
NC score	0.058333 (rank : 1057)	θ value	θ > 10 (rank : 1807)
Query Neighborhood Hits	1804	Target Neighborhood Hits	689	Shared Neighborhood Hits	204
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

DGKA_HUMAN
NC score	0.058258 (rank : 1058)	θ value	θ > 10 (rank : 1818)
Query Neighborhood Hits	1804	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

AFF4_MOUSE
NC score	0.058215 (rank : 1059)	θ value	0.000602161 (rank : 832)
Query Neighborhood Hits	1804	Target Neighborhood Hits	581	Shared Neighborhood Hits	210
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ACINU_HUMAN
NC score	0.057991 (rank : 1060)	θ value	θ > 10 (rank : 1805)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	229
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CBP_HUMAN
NC score	0.057950 (rank : 1061)	θ value	0.21417 (rank : 1120)
Query Neighborhood Hits	1804	Target Neighborhood Hits	941	Shared Neighborhood Hits	356
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DLG5_HUMAN
NC score	0.057926 (rank : 1062)	θ value	0.365318 (rank : 1166)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1088	Shared Neighborhood Hits	286
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

SAPS1_HUMAN
NC score	0.057925 (rank : 1063)	θ value	θ > 10 (rank : 1859)
Query Neighborhood Hits	1804	Target Neighborhood Hits	704	Shared Neighborhood Hits	340
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

CO039_MOUSE
NC score	0.057363 (rank : 1064)	θ value	4.03905 (rank : 1507)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	219
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

ITSN1_MOUSE
NC score	0.057342 (rank : 1065)	θ value	θ > 10 (rank : 1837)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1669	Shared Neighborhood Hits	317
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

CK024_MOUSE
NC score	0.057313 (rank : 1066)	θ value	θ > 10 (rank : 1815)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	131
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

AFF4_HUMAN
NC score	0.057162 (rank : 1067)	θ value	5.44631e-05 (rank : 781)
Query Neighborhood Hits	1804	Target Neighborhood Hits	611	Shared Neighborhood Hits	195
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

NU214_HUMAN
NC score	0.056943 (rank : 1068)	θ value	0.0431538 (rank : 1006)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	219
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

ITSN1_HUMAN
NC score	0.056817 (rank : 1069)	θ value	θ > 10 (rank : 1836)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1757	Shared Neighborhood Hits	315
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

CSKI2_HUMAN
NC score	0.056754 (rank : 1070)	θ value	1.69304e-06 (rank : 697)
Query Neighborhood Hits	1804	Target Neighborhood Hits	747	Shared Neighborhood Hits	234
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

BCL9_MOUSE
NC score	0.056691 (rank : 1071)	θ value	0.813845 (rank : 1256)
Query Neighborhood Hits	1804	Target Neighborhood Hits	770	Shared Neighborhood Hits	332
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

K1543_HUMAN
NC score	0.056588 (rank : 1072)	θ value	0.0961366 (rank : 1054)
Query Neighborhood Hits	1804	Target Neighborhood Hits	435	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

INVO_MOUSE
NC score	0.056414 (rank : 1073)	θ value	2.36792 (rank : 1427)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	125
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

CIC_HUMAN
NC score	0.056372 (rank : 1074)	θ value	1.38821 (rank : 1324)
Query Neighborhood Hits	1804	Target Neighborhood Hits	992	Shared Neighborhood Hits	382
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

RGNEF_MOUSE
NC score	0.056356 (rank : 1075)	θ value	θ > 10 (rank : 1857)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	141
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ZC313_HUMAN
NC score	0.056026 (rank : 1076)	θ value	θ > 10 (rank : 1887)
Query Neighborhood Hits	1804	Target Neighborhood Hits	772	Shared Neighborhood Hits	170
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CSKI2_MOUSE
NC score	0.055878 (rank : 1077)	θ value	1.09739e-05 (rank : 742)
Query Neighborhood Hits	1804	Target Neighborhood Hits	812	Shared Neighborhood Hits	262
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ZO3_MOUSE
NC score	0.055528 (rank : 1078)	θ value	0.0148317 (rank : 938)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	130
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

LIN7B_HUMAN
NC score	0.055470 (rank : 1079)	θ value	0.47712 (rank : 1201)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	124
SwissProt Accessions	Q9HAP6	Gene names	LIN7B, MALS2, VELI2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein) (hVeli2).

EP300_HUMAN
NC score	0.055434 (rank : 1080)	θ value	0.0148317 (rank : 928)
Query Neighborhood Hits	1804	Target Neighborhood Hits	821	Shared Neighborhood Hits	301
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

LIN7A_MOUSE
NC score	0.054816 (rank : 1081)	θ value	4.03905 (rank : 1532)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	Q8JZS0	Gene names	Lin7a, Mals1, Veli1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (mLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein).

LIN7A_HUMAN
NC score	0.054735 (rank : 1082)	θ value	4.03905 (rank : 1531)
Query Neighborhood Hits	1804	Target Neighborhood Hits	193	Shared Neighborhood Hits	123
SwissProt Accessions	O14910, Q6LES3, Q7LDS4	Gene names	LIN7A, MALS1, VELI1
Domain Architecture	No domain graphic available
Description	Lin-7 homolog A (Lin-7A) (hLin-7) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1 protein) (Tax interaction protein 33) (TIP-33).

DLG4_HUMAN
NC score	0.054583 (rank : 1083)	θ value	0.279714 (rank : 1146)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	149
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

FA47B_HUMAN
NC score	0.054405 (rank : 1084)	θ value	2.36792 (rank : 1424)
Query Neighborhood Hits	1804	Target Neighborhood Hits	431	Shared Neighborhood Hits	209
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

ENAH_HUMAN
NC score	0.054326 (rank : 1085)	θ value	5.27518 (rank : 1593)
Query Neighborhood Hits	1804	Target Neighborhood Hits	784	Shared Neighborhood Hits	188
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

MINT_HUMAN
NC score	0.054255 (rank : 1086)	θ value	0.365318 (rank : 1178)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1291	Shared Neighborhood Hits	357
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ARHGC_HUMAN
NC score	0.054167 (rank : 1087)	θ value	0.00298849 (rank : 864)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PCQAP_MOUSE
NC score	0.053940 (rank : 1088)	θ value	0.813845 (rank : 1267)
Query Neighborhood Hits	1804	Target Neighborhood Hits	506	Shared Neighborhood Hits	158
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PDLI2_MOUSE
NC score	0.053919 (rank : 1089)	θ value	1.38821 (rank : 1341)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	107
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

DLG4_MOUSE
NC score	0.053895 (rank : 1090)	θ value	0.279714 (rank : 1147)
Query Neighborhood Hits	1804	Target Neighborhood Hits	282	Shared Neighborhood Hits	146
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

RTP3_MOUSE
NC score	0.053776 (rank : 1091)	θ value	5.27518 (rank : 1630)
Query Neighborhood Hits	1804	Target Neighborhood Hits	374	Shared Neighborhood Hits	201
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

CNOT3_HUMAN
NC score	0.053726 (rank : 1092)	θ value	0.0113563 (rank : 912)
Query Neighborhood Hits	1804	Target Neighborhood Hits	425	Shared Neighborhood Hits	133
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

ITSN2_HUMAN
NC score	0.053580 (rank : 1093)	θ value	θ > 10 (rank : 1838)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1173	Shared Neighborhood Hits	198
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DGKK_HUMAN
NC score	0.053279 (rank : 1094)	θ value	θ > 10 (rank : 1824)
Query Neighborhood Hits	1804	Target Neighborhood Hits	378	Shared Neighborhood Hits	147
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

SFPQ_HUMAN
NC score	0.053197 (rank : 1095)	θ value	0.00102713 (rank : 841)
Query Neighborhood Hits	1804	Target Neighborhood Hits	986	Shared Neighborhood Hits	265
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

LIN7C_HUMAN
NC score	0.053194 (rank : 1096)	θ value	1.81305 (rank : 1374)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NUP9	Gene names	LIN7C, MALS3, VELI3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

LIN7C_MOUSE
NC score	0.053194 (rank : 1097)	θ value	1.81305 (rank : 1375)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	O88952	Gene names	Lin7c, Mals3, Veli3
Domain Architecture	No domain graphic available
Description	Lin-7 homolog C (Lin-7C) (mLin7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3 protein).

ARHGC_MOUSE
NC score	0.053060 (rank : 1098)	θ value	0.00665767 (rank : 887)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	141
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARI1A_HUMAN
NC score	0.053034 (rank : 1099)	θ value	0.0330416 (rank : 972)
Query Neighborhood Hits	1804	Target Neighborhood Hits	787	Shared Neighborhood Hits	302
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

LPP_HUMAN
NC score	0.052980 (rank : 1100)	θ value	0.0330416 (rank : 977)
Query Neighborhood Hits	1804	Target Neighborhood Hits	775	Shared Neighborhood Hits	305
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

SH21A_MOUSE
NC score	0.052870 (rank : 1101)	θ value	θ > 10 (rank : 1860)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

LIN7B_MOUSE
NC score	0.052529 (rank : 1102)	θ value	1.38821 (rank : 1335)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	124
SwissProt Accessions	O88951	Gene names	Lin7b, Mals2, Veli2
Domain Architecture	No domain graphic available
Description	Lin-7 homolog B (Lin-7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2 protein).

SH21B_HUMAN
NC score	0.052479 (rank : 1103)	θ value	θ > 10 (rank : 1861)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	42
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

MAVS_HUMAN
NC score	0.052349 (rank : 1104)	θ value	0.0252991 (rank : 962)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	128
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SFRIP_HUMAN
NC score	0.052182 (rank : 1105)	θ value	6.88961 (rank : 1708)
Query Neighborhood Hits	1804	Target Neighborhood Hits	530	Shared Neighborhood Hits	187
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SET1A_HUMAN
NC score	0.052142 (rank : 1106)	θ value	1.06291 (rank : 1304)
Query Neighborhood Hits	1804	Target Neighborhood Hits	690	Shared Neighborhood Hits	248
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SNTG2_HUMAN
NC score	0.052000 (rank : 1107)	θ value	0.0961366 (rank : 1060)
Query Neighborhood Hits	1804	Target Neighborhood Hits	191	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NY99	Gene names	SNTG2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

T22D4_HUMAN
NC score	0.051734 (rank : 1108)	θ value	θ > 10 (rank : 1873)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

RIMB1_HUMAN
NC score	0.051704 (rank : 1109)	θ value	1.38821 (rank : 1345)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1479	Shared Neighborhood Hits	336
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PININ_MOUSE
NC score	0.051686 (rank : 1110)	θ value	0.0330416 (rank : 979)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	155
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

ASPP2_HUMAN
NC score	0.051618 (rank : 1111)	θ value	0.47712 (rank : 1191)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1156	Shared Neighborhood Hits	276
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

PDLI1_MOUSE
NC score	0.051563 (rank : 1112)	θ value	0.00134147 (rank : 850)
Query Neighborhood Hits	1804	Target Neighborhood Hits	213	Shared Neighborhood Hits	90
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

OGFR_MOUSE
NC score	0.051557 (rank : 1113)	θ value	θ > 10 (rank : 1847)
Query Neighborhood Hits	1804	Target Neighborhood Hits	584	Shared Neighborhood Hits	241
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

PARD3_MOUSE
NC score	0.051545 (rank : 1114)	θ value	1.81305 (rank : 1383)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	135
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PARD3_HUMAN
NC score	0.051429 (rank : 1115)	θ value	4.03905 (rank : 1546)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	145
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

ZO2_MOUSE
NC score	0.051337 (rank : 1116)	θ value	0.0330416 (rank : 993)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

ZN750_MOUSE
NC score	0.051322 (rank : 1117)	θ value	θ > 10 (rank : 1888)
Query Neighborhood Hits	1804	Target Neighborhood Hits	346	Shared Neighborhood Hits	169
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

NCA11_MOUSE
NC score	0.051270 (rank : 1118)	θ value	0.0148317 (rank : 933)
Query Neighborhood Hits	1804	Target Neighborhood Hits	661	Shared Neighborhood Hits	185
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

APBA1_HUMAN
NC score	0.051228 (rank : 1119)	θ value	3.0926 (rank : 1453)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	166
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

RIOK2_HUMAN
NC score	0.051177 (rank : 1120)	θ value	5.27518 (rank : 1629)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

CD2_HUMAN
NC score	0.051129 (rank : 1121)	θ value	3.0926 (rank : 1459)
Query Neighborhood Hits	1804	Target Neighborhood Hits	504	Shared Neighborhood Hits	219
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

GGN_MOUSE
NC score	0.051090 (rank : 1122)	θ value	0.163984 (rank : 1091)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	129
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

WASL_MOUSE
NC score	0.050987 (rank : 1123)	θ value	0.21417 (rank : 1137)
Query Neighborhood Hits	1804	Target Neighborhood Hits	339	Shared Neighborhood Hits	156
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

PDLI4_MOUSE
NC score	0.050985 (rank : 1124)	θ value	0.0431538 (rank : 1007)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	108
SwissProt Accessions	P70271, Q8K0W4	Gene names	Pdlim4, Ril
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

ZO1_MOUSE
NC score	0.050720 (rank : 1125)	θ value	0.163984 (rank : 1116)
Query Neighborhood Hits	1804	Target Neighborhood Hits	453	Shared Neighborhood Hits	205
SwissProt Accessions	P39447	Gene names	Tjp1, Zo1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

MY18A_MOUSE
NC score	0.050603 (rank : 1126)	θ value	0.0961366 (rank : 1057)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1989	Shared Neighborhood Hits	344
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RIMS1_HUMAN
NC score	0.050509 (rank : 1127)	θ value	1.06291 (rank : 1303)
Query Neighborhood Hits	1804	Target Neighborhood Hits	437	Shared Neighborhood Hits	166
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

INVO_HUMAN
NC score	0.050483 (rank : 1128)	θ value	θ > 10 (rank : 1835)
Query Neighborhood Hits	1804	Target Neighborhood Hits	636	Shared Neighborhood Hits	136
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

DAPP1_HUMAN
NC score	0.050423 (rank : 1129)	θ value	θ > 10 (rank : 1816)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ITSN2_MOUSE
NC score	0.050291 (rank : 1130)	θ value	θ > 10 (rank : 1839)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1371	Shared Neighborhood Hits	224
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SYNP2_HUMAN
NC score	0.050290 (rank : 1131)	θ value	4.03905 (rank : 1559)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	190
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

ZO1_HUMAN
NC score	0.050275 (rank : 1132)	θ value	0.813845 (rank : 1279)
Query Neighborhood Hits	1804	Target Neighborhood Hits	474	Shared Neighborhood Hits	226
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZO2_HUMAN
NC score	0.050218 (rank : 1133)	θ value	0.47712 (rank : 1219)
Query Neighborhood Hits	1804	Target Neighborhood Hits	289	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

DLG2_HUMAN
NC score	0.050180 (rank : 1134)	θ value	0.279714 (rank : 1145)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	138
SwissProt Accessions	Q15700, Q59G57, Q68CQ8, Q6ZTA8	Gene names	DLG2
Domain Architecture
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

SYNJ1_HUMAN
NC score	0.050176 (rank : 1135)	θ value	0.000121331 (rank : 799)
Query Neighborhood Hits	1804	Target Neighborhood Hits	498	Shared Neighborhood Hits	210
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

DLG3_MOUSE
NC score	0.050118 (rank : 1136)	θ value	3.0926 (rank : 1464)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	142
SwissProt Accessions	P70175	Gene names	Dlg3, Dlgh3
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102).

MAP1B_MOUSE
NC score	0.049883 (rank : 1137)	θ value	6.88961 (rank : 1686)
Query Neighborhood Hits	1804	Target Neighborhood Hits	977	Shared Neighborhood Hits	263
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

BAG3_HUMAN
NC score	0.049835 (rank : 1138)	θ value	0.0193708 (rank : 940)
Query Neighborhood Hits	1804	Target Neighborhood Hits	314	Shared Neighborhood Hits	164
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

DLG3_HUMAN
NC score	0.049663 (rank : 1139)	θ value	3.0926 (rank : 1463)
Query Neighborhood Hits	1804	Target Neighborhood Hits	269	Shared Neighborhood Hits	139
SwissProt Accessions	Q92796, Q9ULI8	Gene names	DLG3, KIAA1232
Domain Architecture
Description	Discs large homolog 3 (Synapse-associated protein 102) (SAP102) (Neuroendocrine-DLG) (XLMR).

ARI1B_HUMAN
NC score	0.049655 (rank : 1140)	θ value	0.0431538 (rank : 995)
Query Neighborhood Hits	1804	Target Neighborhood Hits	567	Shared Neighborhood Hits	231
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

DLG2_MOUSE
NC score	0.049642 (rank : 1141)	θ value	0.365318 (rank : 1165)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	136
SwissProt Accessions	Q91XM9, Q8BXK7, Q8BYG5	Gene names	Dlg2, Dlgh2
Domain Architecture	No domain graphic available
Description	Discs large homolog 2 (Postsynaptic density protein PSD-93) (Channel- associated protein of synapse-110) (Chapsyn-110).

PSL1_HUMAN
NC score	0.049630 (rank : 1142)	θ value	4.03905 (rank : 1551)
Query Neighborhood Hits	1804	Target Neighborhood Hits	650	Shared Neighborhood Hits	293
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PPRB_MOUSE
NC score	0.049611 (rank : 1143)	θ value	0.125558 (rank : 1077)
Query Neighborhood Hits	1804	Target Neighborhood Hits	354	Shared Neighborhood Hits	159
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

PPRB_HUMAN
NC score	0.049515 (rank : 1144)	θ value	0.0330416 (rank : 980)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	142
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

CRSP2_HUMAN
NC score	0.049511 (rank : 1145)	θ value	0.0330416 (rank : 973)
Query Neighborhood Hits	1804	Target Neighborhood Hits	380	Shared Neighborhood Hits	173
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

ACINU_MOUSE
NC score	0.049351 (rank : 1146)	θ value	0.21417 (rank : 1117)
Query Neighborhood Hits	1804	Target Neighborhood Hits	712	Shared Neighborhood Hits	198
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

LNX1_HUMAN
NC score	0.049336 (rank : 1147)	θ value	0.21417 (rank : 1129)
Query Neighborhood Hits	1804	Target Neighborhood Hits	379	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TBB1, Q8N4C2, Q96MJ7, Q9BY20	Gene names	LNX1, LNX
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-protein X 1).

YLPM1_MOUSE
NC score	0.049270 (rank : 1148)	θ value	0.163984 (rank : 1114)
Query Neighborhood Hits	1804	Target Neighborhood Hits	505	Shared Neighborhood Hits	175
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

RBBP6_HUMAN
NC score	0.048953 (rank : 1149)	θ value	0.163984 (rank : 1103)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1135	Shared Neighborhood Hits	265
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

WASL_HUMAN
NC score	0.048903 (rank : 1150)	θ value	0.813845 (rank : 1276)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	152
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

APBA2_MOUSE
NC score	0.048901 (rank : 1151)	θ value	0.47712 (rank : 1190)
Query Neighborhood Hits	1804	Target Neighborhood Hits	219	Shared Neighborhood Hits	122
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SYNP2_MOUSE
NC score	0.048894 (rank : 1152)	θ value	1.06291 (rank : 1307)
Query Neighborhood Hits	1804	Target Neighborhood Hits	252	Shared Neighborhood Hits	150
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

MY18A_HUMAN
NC score	0.048825 (rank : 1153)	θ value	0.21417 (rank : 1130)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1929	Shared Neighborhood Hits	313
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MILK1_HUMAN
NC score	0.048691 (rank : 1154)	θ value	2.21117e-06 (rank : 704)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	171
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

APBA2_HUMAN
NC score	0.048536 (rank : 1155)	θ value	0.47712 (rank : 1189)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	123
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

MUC13_MOUSE
NC score	0.048501 (rank : 1156)	θ value	0.00869519 (rank : 904)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	136
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

MYO9B_HUMAN
NC score	0.048373 (rank : 1157)	θ value	3.0926 (rank : 1476)
Query Neighborhood Hits	1804	Target Neighborhood Hits	641	Shared Neighborhood Hits	249
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

TACC3_HUMAN
NC score	0.048274 (rank : 1158)	θ value	0.0252991 (rank : 967)
Query Neighborhood Hits	1804	Target Neighborhood Hits	779	Shared Neighborhood Hits	189
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TACC2_HUMAN
NC score	0.048131 (rank : 1159)	θ value	0.21417 (rank : 1135)
Query Neighborhood Hits	1804	Target Neighborhood Hits	856	Shared Neighborhood Hits	214
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

PDLI1_HUMAN
NC score	0.048066 (rank : 1160)	θ value	0.0193708 (rank : 948)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

ROBO3_HUMAN
NC score	0.047454 (rank : 1161)	θ value	0.00134147 (rank : 853)
Query Neighborhood Hits	1804	Target Neighborhood Hits	570	Shared Neighborhood Hits	138
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ZO3_HUMAN
NC score	0.047382 (rank : 1162)	θ value	0.62314 (rank : 1255)
Query Neighborhood Hits	1804	Target Neighborhood Hits	219	Shared Neighborhood Hits	129
SwissProt Accessions	O95049	Gene names	TJP3, ZO3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

MAP1B_HUMAN
NC score	0.047201 (rank : 1163)	θ value	0.125558 (rank : 1071)
Query Neighborhood Hits	1804	Target Neighborhood Hits	903	Shared Neighborhood Hits	246
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

LNX1_MOUSE
NC score	0.047153 (rank : 1164)	θ value	0.365318 (rank : 1177)
Query Neighborhood Hits	1804	Target Neighborhood Hits	377	Shared Neighborhood Hits	124
SwissProt Accessions	O70263, O70264, Q8BRI8, Q8CFR3	Gene names	Lnx1, Lnx
Domain Architecture
Description	Ubiquitin ligase LNX (EC 6.3.2.-) (Numb-binding protein 1) (Ligand of Numb-binding protein 1) (Ligand of Numb-protein X 1).

SFPQ_MOUSE
NC score	0.047014 (rank : 1165)	θ value	1.81305 (rank : 1394)
Query Neighborhood Hits	1804	Target Neighborhood Hits	958	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

PRAX_MOUSE
NC score	0.047003 (rank : 1166)	θ value	0.00869519 (rank : 907)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	103
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

SYN1_HUMAN
NC score	0.046714 (rank : 1167)	θ value	0.0330416 (rank : 990)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	198
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

NCOR1_HUMAN
NC score	0.046661 (rank : 1168)	θ value	0.00869519 (rank : 905)
Query Neighborhood Hits	1804	Target Neighborhood Hits	577	Shared Neighborhood Hits	171
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

MUCDL_HUMAN
NC score	0.046612 (rank : 1169)	θ value	0.0563607 (rank : 1024)
Query Neighborhood Hits	1804	Target Neighborhood Hits	777	Shared Neighborhood Hits	285
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SDCB1_MOUSE
NC score	0.046393 (rank : 1170)	θ value	0.47712 (rank : 1211)
Query Neighborhood Hits	1804	Target Neighborhood Hits	144	Shared Neighborhood Hits	101
SwissProt Accessions	O08992, Q544P5	Gene names	Sdcbp
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Scaffold protein Pbp1).

BRD4_MOUSE
NC score	0.046133 (rank : 1171)	θ value	0.00869519 (rank : 900)
Query Neighborhood Hits	1804	Target Neighborhood Hits	845	Shared Neighborhood Hits	256
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

LNX2_HUMAN
NC score	0.045942 (rank : 1172)	θ value	0.0736092 (rank : 1036)
Query Neighborhood Hits	1804	Target Neighborhood Hits	389	Shared Neighborhood Hits	127
SwissProt Accessions	Q8N448, Q5W0P0, Q6ZMH2, Q96SH4	Gene names	LNX2, PDZRN1
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ domain- containing RING finger protein 1).

TXND2_MOUSE
NC score	0.045932 (rank : 1173)	θ value	0.47712 (rank : 1214)
Query Neighborhood Hits	1804	Target Neighborhood Hits	828	Shared Neighborhood Hits	197
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

BRD4_HUMAN
NC score	0.045914 (rank : 1174)	θ value	0.00390308 (rank : 873)
Query Neighborhood Hits	1804	Target Neighborhood Hits	851	Shared Neighborhood Hits	260
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

PDLI7_HUMAN
NC score	0.045865 (rank : 1175)	θ value	1.81305 (rank : 1384)
Query Neighborhood Hits	1804	Target Neighborhood Hits	547	Shared Neighborhood Hits	246
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

ENL_HUMAN
NC score	0.045701 (rank : 1176)	θ value	0.0431538 (rank : 999)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	115
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

SDCB2_HUMAN
NC score	0.045561 (rank : 1177)	θ value	0.163984 (rank : 1107)
Query Neighborhood Hits	1804	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H190, O95892, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8	Gene names	SDCBP2, SITAC18
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

CJ078_MOUSE
NC score	0.045552 (rank : 1178)	θ value	2.36792 (rank : 1412)
Query Neighborhood Hits	1804	Target Neighborhood Hits	559	Shared Neighborhood Hits	193
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

PRR8_HUMAN
NC score	0.045458 (rank : 1179)	θ value	0.125558 (rank : 1079)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	92
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RPGF6_HUMAN
NC score	0.045275 (rank : 1180)	θ value	0.0113563 (rank : 919)
Query Neighborhood Hits	1804	Target Neighborhood Hits	266	Shared Neighborhood Hits	131
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

PO121_HUMAN
NC score	0.045203 (rank : 1181)	θ value	0.0961366 (rank : 1058)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

SYN1_MOUSE
NC score	0.045201 (rank : 1182)	θ value	0.00869519 (rank : 908)
Query Neighborhood Hits	1804	Target Neighborhood Hits	363	Shared Neighborhood Hits	171
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

ATX2L_HUMAN
NC score	0.045126 (rank : 1183)	θ value	5.27518 (rank : 1577)
Query Neighborhood Hits	1804	Target Neighborhood Hits	443	Shared Neighborhood Hits	191
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

SDCB1_HUMAN
NC score	0.045018 (rank : 1184)	θ value	0.47712 (rank : 1210)
Query Neighborhood Hits	1804	Target Neighborhood Hits	150	Shared Neighborhood Hits	103
SwissProt Accessions	O00560, O00173, O43391	Gene names	SDCBP, MDA9, SYCL
Domain Architecture
Description	Syntenin-1 (Syndecan-binding protein 1) (Melanoma differentiation- associated protein 9) (MDA-9) (Scaffold protein Pbp1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18).

LNX2_MOUSE
NC score	0.045018 (rank : 1185)	θ value	0.163984 (rank : 1096)
Query Neighborhood Hits	1804	Target Neighborhood Hits	407	Shared Neighborhood Hits	136
SwissProt Accessions	Q91XL2, Q8CBE1	Gene names	Lnx2
Domain Architecture
Description	Ligand of Numb-protein X 2 (Numb-binding protein 2).

RAPH1_HUMAN
NC score	0.044886 (rank : 1186)	θ value	0.0330416 (rank : 982)
Query Neighborhood Hits	1804	Target Neighborhood Hits	593	Shared Neighborhood Hits	220
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

TENS1_HUMAN
NC score	0.044801 (rank : 1187)	θ value	0.163984 (rank : 1111)
Query Neighborhood Hits	1804	Target Neighborhood Hits	400	Shared Neighborhood Hits	155
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

K1849_MOUSE
NC score	0.044757 (rank : 1188)	θ value	2.36792 (rank : 1428)
Query Neighborhood Hits	1804	Target Neighborhood Hits	335	Shared Neighborhood Hits	174
SwissProt Accessions	Q69Z89, Q8BNL0, Q8C549, Q8CAL1	Gene names	Kiaa1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

NCOR1_MOUSE
NC score	0.044411 (rank : 1189)	θ value	4.03905 (rank : 1539)
Query Neighborhood Hits	1804	Target Neighborhood Hits	521	Shared Neighborhood Hits	169
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

AKA12_HUMAN
NC score	0.044385 (rank : 1190)	θ value	0.0431538 (rank : 994)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	209
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

PDLI4_HUMAN
NC score	0.044290 (rank : 1191)	θ value	5.27518 (rank : 1624)
Query Neighborhood Hits	1804	Target Neighborhood Hits	245	Shared Neighborhood Hits	114
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PI5PA_MOUSE
NC score	0.044197 (rank : 1192)	θ value	0.00869519 (rank : 906)
Query Neighborhood Hits	1804	Target Neighborhood Hits	331	Shared Neighborhood Hits	157
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

TRDN_HUMAN
NC score	0.044162 (rank : 1193)	θ value	0.0431538 (rank : 1014)
Query Neighborhood Hits	1804	Target Neighborhood Hits	542	Shared Neighborhood Hits	117
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

CS016_HUMAN
NC score	0.044124 (rank : 1194)	θ value	8.99809 (rank : 1738)
Query Neighborhood Hits	1804	Target Neighborhood Hits	310	Shared Neighborhood Hits	147
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

ROBO3_MOUSE
NC score	0.043844 (rank : 1195)	θ value	0.163984 (rank : 1105)
Query Neighborhood Hits	1804	Target Neighborhood Hits	524	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

BCLF1_MOUSE
NC score	0.043487 (rank : 1196)	θ value	0.0431538 (rank : 996)
Query Neighborhood Hits	1804	Target Neighborhood Hits	303	Shared Neighborhood Hits	105
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

CIZ1_HUMAN
NC score	0.043227 (rank : 1197)	θ value	0.0148317 (rank : 927)
Query Neighborhood Hits	1804	Target Neighborhood Hits	359	Shared Neighborhood Hits	134
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

SNTA1_HUMAN
NC score	0.042942 (rank : 1198)	θ value	2.36792 (rank : 1439)
Query Neighborhood Hits	1804	Target Neighborhood Hits	186	Shared Neighborhood Hits	128
SwissProt Accessions	Q13424, Q16438	Gene names	SNTA1, SNT1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin 1).

SPN90_MOUSE
NC score	0.042828 (rank : 1199)	θ value	0.0431538 (rank : 1010)
Query Neighborhood Hits	1804	Target Neighborhood Hits	157	Shared Neighborhood Hits	54
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SFR16_MOUSE
NC score	0.042724 (rank : 1200)	θ value	0.000786445 (rank : 837)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	48
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

PO121_MOUSE
NC score	0.042485 (rank : 1201)	θ value	5.27518 (rank : 1626)
Query Neighborhood Hits	1804	Target Neighborhood Hits	345	Shared Neighborhood Hits	135
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

SNTG1_HUMAN
NC score	0.042473 (rank : 1202)	θ value	4.03905 (rank : 1557)
Query Neighborhood Hits	1804	Target Neighborhood Hits	181	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NSN8, Q9NY98	Gene names	SNTG1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

CO039_HUMAN
NC score	0.042463 (rank : 1203)	θ value	0.125558 (rank : 1067)
Query Neighborhood Hits	1804	Target Neighborhood Hits	264	Shared Neighborhood Hits	132
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CS007_MOUSE
NC score	0.042311 (rank : 1204)	θ value	0.365318 (rank : 1164)
Query Neighborhood Hits	1804	Target Neighborhood Hits	464	Shared Neighborhood Hits	188
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

PELP1_MOUSE
NC score	0.042303 (rank : 1205)	θ value	6.88961 (rank : 1696)
Query Neighborhood Hits	1804	Target Neighborhood Hits	709	Shared Neighborhood Hits	233
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

SNTG1_MOUSE
NC score	0.042293 (rank : 1206)	θ value	4.03905 (rank : 1558)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	122
SwissProt Accessions	Q925E1, Q9D3Z5	Gene names	Sntg1
Domain Architecture
Description	Gamma-1-syntrophin (G1SYN) (Syntrophin 4) (SYN4).

SNTG2_MOUSE
NC score	0.042263 (rank : 1207)	θ value	1.38821 (rank : 1348)
Query Neighborhood Hits	1804	Target Neighborhood Hits	176	Shared Neighborhood Hits	120
SwissProt Accessions	Q925E0	Gene names	Sntg2
Domain Architecture
Description	Gamma-2-syntrophin (G2SYN) (Syntrophin 5) (SYN5).

R3HD2_MOUSE
NC score	0.042256 (rank : 1208)	θ value	8.99809 (rank : 1775)
Query Neighborhood Hits	1804	Target Neighborhood Hits	397	Shared Neighborhood Hits	163
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RPGF2_HUMAN
NC score	0.041921 (rank : 1209)	θ value	0.125558 (rank : 1081)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	130
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RP3A_MOUSE
NC score	0.041627 (rank : 1210)	θ value	0.365318 (rank : 1183)
Query Neighborhood Hits	1804	Target Neighborhood Hits	510	Shared Neighborhood Hits	206
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

CIC_MOUSE
NC score	0.041454 (rank : 1211)	θ value	0.0252991 (rank : 959)
Query Neighborhood Hits	1804	Target Neighborhood Hits	742	Shared Neighborhood Hits	276
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

NEST_HUMAN
NC score	0.041332 (rank : 1212)	θ value	1.81305 (rank : 1379)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1305	Shared Neighborhood Hits	257
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

LAP4_HUMAN
NC score	0.041135 (rank : 1213)	θ value	0.0193708 (rank : 947)
Query Neighborhood Hits	1804	Target Neighborhood Hits	608	Shared Neighborhood Hits	186
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

MILK2_HUMAN
NC score	0.041099 (rank : 1214)	θ value	6.43352e-06 (rank : 731)
Query Neighborhood Hits	1804	Target Neighborhood Hits	457	Shared Neighborhood Hits	165
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

IASPP_HUMAN
NC score	0.040871 (rank : 1215)	θ value	5.27518 (rank : 1596)
Query Neighborhood Hits	1804	Target Neighborhood Hits	688	Shared Neighborhood Hits	201
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MY18B_HUMAN
NC score	0.040720 (rank : 1216)	θ value	4.03905 (rank : 1537)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1299	Shared Neighborhood Hits	262
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

SDCB2_MOUSE
NC score	0.040604 (rank : 1217)	θ value	0.125558 (rank : 1082)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	84
SwissProt Accessions	Q99JZ0	Gene names	Sdcbp2
Domain Architecture
Description	Syntenin-2 (Syndecan-binding protein 2).

SMOO_HUMAN
NC score	0.040592 (rank : 1218)	θ value	0.0563607 (rank : 1028)
Query Neighborhood Hits	1804	Target Neighborhood Hits	391	Shared Neighborhood Hits	166
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

AMPH_HUMAN
NC score	0.040577 (rank : 1219)	θ value	3.0926 (rank : 1452)
Query Neighborhood Hits	1804	Target Neighborhood Hits	455	Shared Neighborhood Hits	169
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

HMGA2_HUMAN
NC score	0.040375 (rank : 1220)	θ value	0.0113563 (rank : 917)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	23
SwissProt Accessions	P52926	Gene names	HMGA2, HMGIC
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

SEPT9_HUMAN
NC score	0.040259 (rank : 1221)	θ value	0.62314 (rank : 1248)
Query Neighborhood Hits	1804	Target Neighborhood Hits	706	Shared Neighborhood Hits	292
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SNTA1_MOUSE
NC score	0.039761 (rank : 1222)	θ value	5.27518 (rank : 1634)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	119
SwissProt Accessions	Q61234, Q8VEF3	Gene names	Snta1, Snt1
Domain Architecture
Description	Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Syntrophin 1).

SFR16_HUMAN
NC score	0.039584 (rank : 1223)	θ value	0.0330416 (rank : 985)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

MLL4_HUMAN
NC score	0.039169 (rank : 1224)	θ value	0.0736092 (rank : 1038)
Query Neighborhood Hits	1804	Target Neighborhood Hits	722	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PHLB1_MOUSE
NC score	0.039164 (rank : 1225)	θ value	0.0113563 (rank : 918)
Query Neighborhood Hits	1804	Target Neighborhood Hits	678	Shared Neighborhood Hits	176
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

ATX2_MOUSE
NC score	0.039154 (rank : 1226)	θ value	1.81305 (rank : 1357)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	189
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

K1802_HUMAN
NC score	0.039149 (rank : 1227)	θ value	0.00509761 (rank : 884)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1378	Shared Neighborhood Hits	359
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CCD21_MOUSE
NC score	0.039003 (rank : 1228)	θ value	6.88961 (rank : 1657)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1135	Shared Neighborhood Hits	189
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

NFH_HUMAN
NC score	0.038920 (rank : 1229)	θ value	1.63604e-09 (rank : 559)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1242	Shared Neighborhood Hits	301
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ANR11_HUMAN
NC score	0.038868 (rank : 1230)	θ value	8.99809 (rank : 1726)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1289	Shared Neighborhood Hits	312
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

MPP4_HUMAN
NC score	0.038840 (rank : 1231)	θ value	8.99809 (rank : 1767)
Query Neighborhood Hits	1804	Target Neighborhood Hits	205	Shared Neighborhood Hits	114
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

IL16_HUMAN
NC score	0.038674 (rank : 1232)	θ value	0.62314 (rank : 1234)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	118
SwissProt Accessions	Q14005, Q16435, Q9UP18	Gene names	IL16
Domain Architecture
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

K1849_HUMAN
NC score	0.038662 (rank : 1233)	θ value	4.03905 (rank : 1525)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	120
SwissProt Accessions	Q96JH8, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4	Gene names	KIAA1849
Domain Architecture	No domain graphic available
Description	Protein KIAA1849.

BAZ2A_MOUSE
NC score	0.038634 (rank : 1234)	θ value	3.0926 (rank : 1455)
Query Neighborhood Hits	1804	Target Neighborhood Hits	744	Shared Neighborhood Hits	261
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

APC_HUMAN
NC score	0.038045 (rank : 1235)	θ value	0.62314 (rank : 1222)
Query Neighborhood Hits	1804	Target Neighborhood Hits	603	Shared Neighborhood Hits	187
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CF150_HUMAN
NC score	0.037853 (rank : 1236)	θ value	0.21417 (rank : 1122)
Query Neighborhood Hits	1804	Target Neighborhood Hits	96	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N884, Q32NC9, Q5SWL0, Q5SWL1, Q96E45	Gene names	C6orf150
Domain Architecture	No domain graphic available
Description	Protein C6orf150.

SFR12_MOUSE
NC score	0.037822 (rank : 1237)	θ value	8.99809 (rank : 1783)
Query Neighborhood Hits	1804	Target Neighborhood Hits	486	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

LDB3_HUMAN
NC score	0.037788 (rank : 1238)	θ value	0.00390308 (rank : 874)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	195
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

ATX2_HUMAN
NC score	0.037613 (rank : 1239)	θ value	0.0252991 (rank : 955)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	145
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

LAP4_MOUSE
NC score	0.037414 (rank : 1240)	θ value	0.21417 (rank : 1128)
Query Neighborhood Hits	1804	Target Neighborhood Hits	590	Shared Neighborhood Hits	188
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

TACC2_MOUSE
NC score	0.037357 (rank : 1241)	θ value	6.88961 (rank : 1713)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	197
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

THOC2_HUMAN
NC score	0.037107 (rank : 1242)	θ value	0.0330416 (rank : 992)
Query Neighborhood Hits	1804	Target Neighborhood Hits	337	Shared Neighborhood Hits	106
SwissProt Accessions	Q8NI27, Q9H8I6	Gene names	THOC2, CXorf3
Domain Architecture	No domain graphic available
Description	THO complex subunit 2 (Tho2).

PKHA6_MOUSE
NC score	0.037060 (rank : 1243)	θ value	6.88961 (rank : 1698)
Query Neighborhood Hits	1804	Target Neighborhood Hits	591	Shared Neighborhood Hits	179
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

AFF2_HUMAN
NC score	0.036965 (rank : 1244)	θ value	1.81305 (rank : 1355)
Query Neighborhood Hits	1804	Target Neighborhood Hits	218	Shared Neighborhood Hits	102
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

JIP3_HUMAN
NC score	0.036717 (rank : 1245)	θ value	0.62314 (rank : 1237)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1039	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

SASH1_MOUSE
NC score	0.036676 (rank : 1246)	θ value	1.81305 (rank : 1393)
Query Neighborhood Hits	1804	Target Neighborhood Hits	263	Shared Neighborhood Hits	112
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CS007_HUMAN
NC score	0.036371 (rank : 1247)	θ value	0.0193708 (rank : 944)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	161
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

RL1D1_HUMAN
NC score	0.036201 (rank : 1248)	θ value	1.81305 (rank : 1392)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	O76021, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9	Gene names	RSL1D1, CATX11, CSIG, PBK1
Domain Architecture	No domain graphic available
Description	Ribosomal L1 domain-containing protein 1 (Cellular senescence- inhibited gene protein) (Protein PBK1) (CATX-11).

TB182_HUMAN
NC score	0.036079 (rank : 1249)	θ value	1.38821 (rank : 1351)
Query Neighborhood Hits	1804	Target Neighborhood Hits	414	Shared Neighborhood Hits	165
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

IRS2_HUMAN
NC score	0.036068 (rank : 1250)	θ value	0.62314 (rank : 1236)
Query Neighborhood Hits	1804	Target Neighborhood Hits	262	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

TROAP_HUMAN
NC score	0.035796 (rank : 1251)	θ value	1.38821 (rank : 1352)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	123
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

NTBP1_MOUSE
NC score	0.035678 (rank : 1252)	θ value	0.365318 (rank : 1179)
Query Neighborhood Hits	1804	Target Neighborhood Hits	528	Shared Neighborhood Hits	119
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

PHC2_HUMAN
NC score	0.035612 (rank : 1253)	θ value	8.99809 (rank : 1774)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	172
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

ELOA1_HUMAN
NC score	0.035394 (rank : 1254)	θ value	1.38821 (rank : 1328)
Query Neighborhood Hits	1804	Target Neighborhood Hits	388	Shared Neighborhood Hits	131
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

TM108_HUMAN
NC score	0.035261 (rank : 1255)	θ value	3.0926 (rank : 1489)
Query Neighborhood Hits	1804	Target Neighborhood Hits	166	Shared Neighborhood Hits	91
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

MUC2_HUMAN
NC score	0.035225 (rank : 1256)	θ value	3.0926 (rank : 1475)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	239
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

LIPS_HUMAN
NC score	0.035144 (rank : 1257)	θ value	1.06291 (rank : 1296)
Query Neighborhood Hits	1804	Target Neighborhood Hits	314	Shared Neighborhood Hits	165
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

RPB1_MOUSE
NC score	0.034981 (rank : 1258)	θ value	0.62314 (rank : 1246)
Query Neighborhood Hits	1804	Target Neighborhood Hits	363	Shared Neighborhood Hits	143
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

MYO9B_MOUSE
NC score	0.034911 (rank : 1259)	θ value	6.88961 (rank : 1687)
Query Neighborhood Hits	1804	Target Neighborhood Hits	311	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

RRBP1_HUMAN
NC score	0.034894 (rank : 1260)	θ value	0.0330416 (rank : 984)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1306	Shared Neighborhood Hits	223
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

IF4B_HUMAN
NC score	0.034768 (rank : 1261)	θ value	0.365318 (rank : 1175)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	159
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

PKHA6_HUMAN
NC score	0.034705 (rank : 1262)	θ value	4.03905 (rank : 1549)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	161
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

BAZ2A_HUMAN
NC score	0.034397 (rank : 1263)	θ value	1.38821 (rank : 1322)
Query Neighborhood Hits	1804	Target Neighborhood Hits	780	Shared Neighborhood Hits	264
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CCD41_MOUSE
NC score	0.034326 (rank : 1264)	θ value	8.99809 (rank : 1733)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1399	Shared Neighborhood Hits	179
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

T22D2_HUMAN
NC score	0.034225 (rank : 1265)	θ value	1.06291 (rank : 1308)
Query Neighborhood Hits	1804	Target Neighborhood Hits	250	Shared Neighborhood Hits	109
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

K2027_HUMAN
NC score	0.034215 (rank : 1266)	θ value	6.88961 (rank : 1683)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	93
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

RPB1_HUMAN
NC score	0.034150 (rank : 1267)	θ value	0.62314 (rank : 1245)
Query Neighborhood Hits	1804	Target Neighborhood Hits	362	Shared Neighborhood Hits	144
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

TENS4_HUMAN
NC score	0.034067 (rank : 1268)	θ value	0.62314 (rank : 1251)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

LR37A_HUMAN
NC score	0.034051 (rank : 1269)	θ value	5.27518 (rank : 1607)
Query Neighborhood Hits	1804	Target Neighborhood Hits	720	Shared Neighborhood Hits	225
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

R51A1_MOUSE
NC score	0.033960 (rank : 1270)	θ value	0.0330416 (rank : 981)
Query Neighborhood Hits	1804	Target Neighborhood Hits	164	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C551, O55219, Q8BP36, Q99L94, Q9D0J0	Gene names	Rad51ap1
Domain Architecture	No domain graphic available
Description	RAD51-associated protein 1 (RAD51-interacting protein) (RAB22).

WASF2_MOUSE
NC score	0.033813 (rank : 1271)	θ value	0.163984 (rank : 1113)
Query Neighborhood Hits	1804	Target Neighborhood Hits	315	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

GA2L3_HUMAN
NC score	0.033709 (rank : 1272)	θ value	0.365318 (rank : 1172)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	98
SwissProt Accessions	Q86XJ1	Gene names	GAS2L3
Domain Architecture	No domain graphic available
Description	GAS2-like protein 3 (Growth arrest-specific 2-like 3).

DACT1_HUMAN
NC score	0.033419 (rank : 1273)	θ value	6.88961 (rank : 1668)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

REXO1_HUMAN
NC score	0.033308 (rank : 1274)	θ value	0.0431538 (rank : 1008)
Query Neighborhood Hits	1804	Target Neighborhood Hits	242	Shared Neighborhood Hits	116
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

PHC1_HUMAN
NC score	0.033144 (rank : 1275)	θ value	0.125558 (rank : 1076)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	94
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

PHC1_MOUSE
NC score	0.032917 (rank : 1276)	θ value	3.19293e-05 (rank : 769)
Query Neighborhood Hits	1804	Target Neighborhood Hits	205	Shared Neighborhood Hits	79
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

HRX_HUMAN
NC score	0.032900 (rank : 1277)	θ value	1.81305 (rank : 1370)
Query Neighborhood Hits	1804	Target Neighborhood Hits	825	Shared Neighborhood Hits	269
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

LCP2_MOUSE
NC score	0.032861 (rank : 1278)	θ value	8.99809 (rank : 1758)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TCF20_MOUSE
NC score	0.032839 (rank : 1279)	θ value	5.27518 (rank : 1638)
Query Neighborhood Hits	1804	Target Neighborhood Hits	396	Shared Neighborhood Hits	156
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

TCGAP_HUMAN
NC score	0.032807 (rank : 1280)	θ value	4.03905 (rank : 1562)
Query Neighborhood Hits	1804	Target Neighborhood Hits	872	Shared Neighborhood Hits	305
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

WASP_HUMAN
NC score	0.032794 (rank : 1281)	θ value	0.813845 (rank : 1277)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

MADCA_HUMAN
NC score	0.032696 (rank : 1282)	θ value	1.38821 (rank : 1336)
Query Neighborhood Hits	1804	Target Neighborhood Hits	221	Shared Neighborhood Hits	105
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

WASP_MOUSE
NC score	0.032684 (rank : 1283)	θ value	4.03905 (rank : 1566)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	110
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

CEP35_HUMAN
NC score	0.032555 (rank : 1284)	θ value	4.03905 (rank : 1504)
Query Neighborhood Hits	1804	Target Neighborhood Hits	811	Shared Neighborhood Hits	159
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

PELP1_HUMAN
NC score	0.032425 (rank : 1285)	θ value	4.03905 (rank : 1547)
Query Neighborhood Hits	1804	Target Neighborhood Hits	596	Shared Neighborhood Hits	163
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

RGS12_HUMAN
NC score	0.032343 (rank : 1286)	θ value	1.81305 (rank : 1391)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	167
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

CCD96_HUMAN
NC score	0.032330 (rank : 1287)	θ value	3.0926 (rank : 1457)
Query Neighborhood Hits	1804	Target Neighborhood Hits	595	Shared Neighborhood Hits	119
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

WASF4_HUMAN
NC score	0.031868 (rank : 1288)	θ value	4.03905 (rank : 1565)
Query Neighborhood Hits	1804	Target Neighborhood Hits	282	Shared Neighborhood Hits	120
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

PICK1_MOUSE
NC score	0.031649 (rank : 1289)	θ value	1.81305 (rank : 1387)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	82
SwissProt Accessions	Q62083	Gene names	Pick1, Prkcabp
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

INVS_MOUSE
NC score	0.031546 (rank : 1290)	θ value	1.81305 (rank : 1371)
Query Neighborhood Hits	1804	Target Neighborhood Hits	609	Shared Neighborhood Hits	200
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

CRTC1_MOUSE
NC score	0.031436 (rank : 1291)	θ value	0.0736092 (rank : 1031)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	110
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

PICK1_HUMAN
NC score	0.031414 (rank : 1292)	θ value	1.81305 (rank : 1386)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRD5, O95906	Gene names	PICK1, PRKCABP
Domain Architecture
Description	PRKCA-binding protein (Protein kinase C-alpha-binding protein) (Protein interacting with C kinase 1).

CCNK_MOUSE
NC score	0.031380 (rank : 1293)	θ value	6.88961 (rank : 1658)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	132
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

TXLNB_MOUSE
NC score	0.031363 (rank : 1294)	θ value	6.88961 (rank : 1714)
Query Neighborhood Hits	1804	Target Neighborhood Hits	640	Shared Neighborhood Hits	116
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

NEUM_HUMAN
NC score	0.031319 (rank : 1295)	θ value	3.0926 (rank : 1477)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	62
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

TCF20_HUMAN
NC score	0.031172 (rank : 1296)	θ value	0.163984 (rank : 1110)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	137
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

RAI1_HUMAN
NC score	0.030856 (rank : 1297)	θ value	1.06291 (rank : 1301)
Query Neighborhood Hits	1804	Target Neighborhood Hits	360	Shared Neighborhood Hits	164
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

PHAR2_HUMAN
NC score	0.030720 (rank : 1298)	θ value	0.279714 (rank : 1154)
Query Neighborhood Hits	1804	Target Neighborhood Hits	208	Shared Neighborhood Hits	85
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

HMGA2_MOUSE
NC score	0.030719 (rank : 1299)	θ value	0.0736092 (rank : 1032)
Query Neighborhood Hits	1804	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P52927, Q3UQW0	Gene names	Hmga2, Hmgic
Domain Architecture	No domain graphic available
Description	High mobility group protein HMGI-C (High mobility group AT-hook protein 2).

CROCC_MOUSE
NC score	0.030600 (rank : 1300)	θ value	8.99809 (rank : 1737)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1460	Shared Neighborhood Hits	178
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

PDLI5_HUMAN
NC score	0.030584 (rank : 1301)	θ value	8.99809 (rank : 1773)
Query Neighborhood Hits	1804	Target Neighborhood Hits	322	Shared Neighborhood Hits	142
SwissProt Accessions	Q96HC4, O60705	Gene names	PDLIM5, ENH
Domain Architecture
Description	PDZ and LIM domain protein 5 (Enigma homolog) (Enigma-like PDZ and LIM domains protein).

PDLI7_MOUSE
NC score	0.030240 (rank : 1302)	θ value	1.06291 (rank : 1299)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	108
SwissProt Accessions	Q3TJD7, Q80ZY6, Q810S3, Q8C1S4, Q9CRA1	Gene names	Pdlim7, Enigma
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

LARP4_MOUSE
NC score	0.030232 (rank : 1303)	θ value	3.0926 (rank : 1470)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	123
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

CK5P2_HUMAN
NC score	0.029916 (rank : 1304)	θ value	5.27518 (rank : 1583)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1433	Shared Neighborhood Hits	197
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

TP53B_HUMAN
NC score	0.029912 (rank : 1305)	θ value	1.06291 (rank : 1312)
Query Neighborhood Hits	1804	Target Neighborhood Hits	413	Shared Neighborhood Hits	144
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

CSPG5_MOUSE
NC score	0.029910 (rank : 1306)	θ value	0.62314 (rank : 1227)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	81
SwissProt Accessions	Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32	Gene names	Cspg5, Caleb, Ngc
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

CGRE1_HUMAN
NC score	0.029877 (rank : 1307)	θ value	4.03905 (rank : 1505)
Query Neighborhood Hits	1804	Target Neighborhood Hits	354	Shared Neighborhood Hits	127
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

INP5E_HUMAN
NC score	0.029867 (rank : 1308)	θ value	0.163984 (rank : 1095)
Query Neighborhood Hits	1804	Target Neighborhood Hits	201	Shared Neighborhood Hits	98
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

ZN318_MOUSE
NC score	0.029775 (rank : 1309)	θ value	8.99809 (rank : 1803)
Query Neighborhood Hits	1804	Target Neighborhood Hits	642	Shared Neighborhood Hits	161
SwissProt Accessions	Q99PP2, Q3TZL5, Q9JJ01	Gene names	Znf318, Tzf, Zfp318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Testicular zinc finger protein).

CROCC_HUMAN
NC score	0.029689 (rank : 1310)	θ value	4.03905 (rank : 1510)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1409	Shared Neighborhood Hits	170
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

PZRN3_HUMAN
NC score	0.029575 (rank : 1311)	θ value	1.38821 (rank : 1344)
Query Neighborhood Hits	1804	Target Neighborhood Hits	461	Shared Neighborhood Hits	136
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

NEUM_MOUSE
NC score	0.029530 (rank : 1312)	θ value	8.99809 (rank : 1770)
Query Neighborhood Hits	1804	Target Neighborhood Hits	149	Shared Neighborhood Hits	76
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

PZRN3_MOUSE
NC score	0.029515 (rank : 1313)	θ value	3.0926 (rank : 1484)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	133
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

CK5P2_MOUSE
NC score	0.029501 (rank : 1314)	θ value	1.81305 (rank : 1362)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1151	Shared Neighborhood Hits	153
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

K0460_MOUSE
NC score	0.029425 (rank : 1315)	θ value	0.62314 (rank : 1238)
Query Neighborhood Hits	1804	Target Neighborhood Hits	374	Shared Neighborhood Hits	138
SwissProt Accessions	Q6NXI6, Q3U3L8, Q6ZQA7	Gene names	Kiaa0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

IRS2_MOUSE
NC score	0.029268 (rank : 1316)	θ value	0.47712 (rank : 1200)
Query Neighborhood Hits	1804	Target Neighborhood Hits	248	Shared Neighborhood Hits	102
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

HCN4_MOUSE
NC score	0.029246 (rank : 1317)	θ value	0.00228821 (rank : 859)
Query Neighborhood Hits	1804	Target Neighborhood Hits	284	Shared Neighborhood Hits	118
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

WASF3_HUMAN
NC score	0.029220 (rank : 1318)	θ value	1.81305 (rank : 1403)
Query Neighborhood Hits	1804	Target Neighborhood Hits	204	Shared Neighborhood Hits	98
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

KTN1_MOUSE
NC score	0.029158 (rank : 1319)	θ value	2.36792 (rank : 1431)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1324	Shared Neighborhood Hits	167
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

PERQ1_MOUSE
NC score	0.029149 (rank : 1320)	θ value	0.813845 (rank : 1268)
Query Neighborhood Hits	1804	Target Neighborhood Hits	215	Shared Neighborhood Hits	54
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

CECR2_HUMAN
NC score	0.029124 (rank : 1321)	θ value	8.99809 (rank : 1734)
Query Neighborhood Hits	1804	Target Neighborhood Hits	543	Shared Neighborhood Hits	214
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BCLF1_HUMAN
NC score	0.029041 (rank : 1322)	θ value	1.06291 (rank : 1283)
Query Neighborhood Hits	1804	Target Neighborhood Hits	298	Shared Neighborhood Hits	105
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

K2027_MOUSE
NC score	0.028969 (rank : 1323)	θ value	0.365318 (rank : 1176)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BWS5, Q69Z30	Gene names	Kiaa2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

ABI2_HUMAN
NC score	0.028966 (rank : 1324)	θ value	2.36792 (rank : 1406)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

IF4B_MOUSE
NC score	0.028494 (rank : 1325)	θ value	1.38821 (rank : 1332)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	135
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

MNT_HUMAN
NC score	0.028456 (rank : 1326)	θ value	8.99809 (rank : 1766)
Query Neighborhood Hits	1804	Target Neighborhood Hits	496	Shared Neighborhood Hits	162
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

RAI14_MOUSE
NC score	0.028430 (rank : 1327)	θ value	6.88961 (rank : 1701)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1505	Shared Neighborhood Hits	199
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

DNMT1_HUMAN
NC score	0.028418 (rank : 1328)	θ value	6.88961 (rank : 1670)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	126
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

GOGA3_HUMAN
NC score	0.028303 (rank : 1329)	θ value	8.99809 (rank : 1747)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1317	Shared Neighborhood Hits	175
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

HN1L_HUMAN
NC score	0.028298 (rank : 1330)	θ value	0.0563607 (rank : 1023)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

PDLI3_MOUSE
NC score	0.028171 (rank : 1331)	θ value	8.99809 (rank : 1772)
Query Neighborhood Hits	1804	Target Neighborhood Hits	197	Shared Neighborhood Hits	92
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

ANKS1_HUMAN
NC score	0.028119 (rank : 1332)	θ value	0.47712 (rank : 1188)
Query Neighborhood Hits	1804	Target Neighborhood Hits	438	Shared Neighborhood Hits	95
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

AUTS2_HUMAN
NC score	0.028038 (rank : 1333)	θ value	4.03905 (rank : 1497)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

SGIP1_HUMAN
NC score	0.028008 (rank : 1334)	θ value	1.38821 (rank : 1347)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

GA2L1_HUMAN
NC score	0.027998 (rank : 1335)	θ value	0.0563607 (rank : 1019)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	87
SwissProt Accessions	Q99501, Q53EN7, Q92640, Q9BUY9	Gene names	GAS2L1, GAR22
Domain Architecture
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein).

GA2L1_MOUSE
NC score	0.027981 (rank : 1336)	θ value	0.0113563 (rank : 915)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	Q8JZP9, Q5SVG0, Q8K573	Gene names	Gas2l1
Domain Architecture	No domain graphic available
Description	GAS2-like protein 1 (Growth arrest-specific 2-like 1).

3BP2_HUMAN
NC score	0.027918 (rank : 1337)	θ value	1.38821 (rank : 1318)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	116
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SF3A2_MOUSE
NC score	0.027890 (rank : 1338)	θ value	8.99809 (rank : 1782)
Query Neighborhood Hits	1804	Target Neighborhood Hits	247	Shared Neighborhood Hits	84
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

CEP63_HUMAN
NC score	0.027628 (rank : 1339)	θ value	8.99809 (rank : 1735)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1005	Shared Neighborhood Hits	130
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

PTN13_MOUSE
NC score	0.027578 (rank : 1340)	θ value	0.365318 (rank : 1182)
Query Neighborhood Hits	1804	Target Neighborhood Hits	426	Shared Neighborhood Hits	161
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

EMSY_HUMAN
NC score	0.027564 (rank : 1341)	θ value	6.88961 (rank : 1673)
Query Neighborhood Hits	1804	Target Neighborhood Hits	296	Shared Neighborhood Hits	113
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

ZN318_HUMAN
NC score	0.027536 (rank : 1342)	θ value	0.125558 (rank : 1084)
Query Neighborhood Hits	1804	Target Neighborhood Hits	497	Shared Neighborhood Hits	121
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

RAI1_MOUSE
NC score	0.027499 (rank : 1343)	θ value	3.0926 (rank : 1485)
Query Neighborhood Hits	1804	Target Neighborhood Hits	344	Shared Neighborhood Hits	141
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

WASF2_HUMAN
NC score	0.027465 (rank : 1344)	θ value	1.81305 (rank : 1402)
Query Neighborhood Hits	1804	Target Neighborhood Hits	280	Shared Neighborhood Hits	106
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

CUTL1_HUMAN
NC score	0.027462 (rank : 1345)	θ value	0.163984 (rank : 1088)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1574	Shared Neighborhood Hits	261
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

WASF1_MOUSE
NC score	0.027307 (rank : 1346)	θ value	1.06291 (rank : 1316)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	103
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

APC_MOUSE
NC score	0.027243 (rank : 1347)	θ value	1.38821 (rank : 1319)
Query Neighborhood Hits	1804	Target Neighborhood Hits	441	Shared Neighborhood Hits	118
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

NFM_HUMAN
NC score	0.027234 (rank : 1348)	θ value	6.88961 (rank : 1689)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1328	Shared Neighborhood Hits	285
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NSD1_HUMAN
NC score	0.027164 (rank : 1349)	θ value	0.00665767 (rank : 892)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	148
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NRG2_HUMAN
NC score	0.027147 (rank : 1350)	θ value	5.27518 (rank : 1617)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	87
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

LZTS2_MOUSE
NC score	0.027117 (rank : 1351)	θ value	4.03905 (rank : 1533)
Query Neighborhood Hits	1804	Target Neighborhood Hits	423	Shared Neighborhood Hits	83
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

DSPP_HUMAN
NC score	0.027039 (rank : 1352)	θ value	4.03905 (rank : 1512)
Query Neighborhood Hits	1804	Target Neighborhood Hits	645	Shared Neighborhood Hits	160
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SYN3_MOUSE
NC score	0.026978 (rank : 1353)	θ value	5.27518 (rank : 1636)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	105
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

SI1L3_HUMAN
NC score	0.026968 (rank : 1354)	θ value	0.163984 (rank : 1108)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	150
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

CPSF6_MOUSE
NC score	0.026949 (rank : 1355)	θ value	2.36792 (rank : 1420)
Query Neighborhood Hits	1804	Target Neighborhood Hits	356	Shared Neighborhood Hits	130
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

SETX_HUMAN
NC score	0.026921 (rank : 1356)	θ value	0.0736092 (rank : 1044)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	124
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

WASF1_HUMAN
NC score	0.026854 (rank : 1357)	θ value	1.06291 (rank : 1315)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	101
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

PARM1_MOUSE
NC score	0.026833 (rank : 1358)	θ value	5.27518 (rank : 1620)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	59
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

ZCPW1_MOUSE
NC score	0.026774 (rank : 1359)	θ value	6.88961 (rank : 1718)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	111
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

MUC5B_HUMAN
NC score	0.026723 (rank : 1360)	θ value	5.27518 (rank : 1613)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1020	Shared Neighborhood Hits	245
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CYTSA_HUMAN
NC score	0.026698 (rank : 1361)	θ value	0.163984 (rank : 1089)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1138	Shared Neighborhood Hits	173
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

HCN2_HUMAN
NC score	0.026623 (rank : 1362)	θ value	3.0926 (rank : 1466)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	155
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HASP_MOUSE
NC score	0.026578 (rank : 1363)	θ value	0.365318 (rank : 1173)
Query Neighborhood Hits	1804	Target Neighborhood Hits	50	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z0R0, Q99MU9, Q9JJJ4	Gene names	Gsg2
Domain Architecture
Description	Serine/threonine-protein kinase Haspin (EC 2.7.11.1) (Haploid germ cell-specific nuclear protein kinase) (Germ cell-specific gene 2 protein).

SOX13_MOUSE
NC score	0.026413 (rank : 1364)	θ value	1.38821 (rank : 1349)
Query Neighborhood Hits	1804	Target Neighborhood Hits	495	Shared Neighborhood Hits	195
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

FYB_MOUSE
NC score	0.026395 (rank : 1365)	θ value	4.03905 (rank : 1518)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	66
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

CPSF6_HUMAN
NC score	0.026334 (rank : 1366)	θ value	2.36792 (rank : 1419)
Query Neighborhood Hits	1804	Target Neighborhood Hits	359	Shared Neighborhood Hits	127
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CU030_HUMAN
NC score	0.026323 (rank : 1367)	θ value	0.0193708 (rank : 945)
Query Neighborhood Hits	1804	Target Neighborhood Hits	36	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UFM2	Gene names	C21orf30
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C21orf30.

SH22A_MOUSE
NC score	0.026249 (rank : 1368)	θ value	6.88961 (rank : 1709)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

PTN13_HUMAN
NC score	0.026233 (rank : 1369)	θ value	0.0563607 (rank : 1027)
Query Neighborhood Hits	1804	Target Neighborhood Hits	471	Shared Neighborhood Hits	176
SwissProt Accessions	Q12923, Q15159, Q15263, Q15264, Q15265, Q15674, Q16826, Q8IWH7, Q9NYN9	Gene names	PTPN13, PNP1, PTP1E, PTPL1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (PTP-BAS) (Protein-tyrosine phosphatase PTPL1) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1).

RFIP1_HUMAN
NC score	0.026179 (rank : 1370)	θ value	1.06291 (rank : 1302)
Query Neighborhood Hits	1804	Target Neighborhood Hits	236	Shared Neighborhood Hits	94
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

ELOA2_HUMAN
NC score	0.026084 (rank : 1371)	θ value	0.0330416 (rank : 974)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

LSD1_HUMAN
NC score	0.025902 (rank : 1372)	θ value	1.81305 (rank : 1376)
Query Neighborhood Hits	1804	Target Neighborhood Hits	455	Shared Neighborhood Hits	139
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

SOX13_HUMAN
NC score	0.025688 (rank : 1373)	θ value	0.0252991 (rank : 966)
Query Neighborhood Hits	1804	Target Neighborhood Hits	464	Shared Neighborhood Hits	183
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

EVL_HUMAN
NC score	0.025590 (rank : 1374)	θ value	4.03905 (rank : 1514)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	120
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

PP1RA_HUMAN
NC score	0.025540 (rank : 1375)	θ value	0.62314 (rank : 1244)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	85
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

SRBS1_MOUSE
NC score	0.025504 (rank : 1376)	θ value	0.813845 (rank : 1272)
Query Neighborhood Hits	1804	Target Neighborhood Hits	409	Shared Neighborhood Hits	137
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HGS_MOUSE
NC score	0.025410 (rank : 1377)	θ value	1.38821 (rank : 1330)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	175
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

MEGF9_MOUSE
NC score	0.025353 (rank : 1378)	θ value	5.27518 (rank : 1612)
Query Neighborhood Hits	1804	Target Neighborhood Hits	896	Shared Neighborhood Hits	271
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

ASXL1_HUMAN
NC score	0.025312 (rank : 1379)	θ value	3.0926 (rank : 1454)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	104
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

FA21C_HUMAN
NC score	0.025222 (rank : 1380)	θ value	0.365318 (rank : 1170)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y4E1, Q5SQU4, Q5SQU5, Q7L521, Q9UG79	Gene names	FAM21C, KIAA0592
Domain Architecture	No domain graphic available
Description	Protein FAM21C.

GON4L_HUMAN
NC score	0.025208 (rank : 1381)	θ value	8.99809 (rank : 1748)
Query Neighborhood Hits	1804	Target Neighborhood Hits	555	Shared Neighborhood Hits	191
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

CO3A1_HUMAN
NC score	0.025196 (rank : 1382)	θ value	0.0113563 (rank : 913)
Query Neighborhood Hits	1804	Target Neighborhood Hits	452	Shared Neighborhood Hits	148
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

TCP10_HUMAN
NC score	0.025123 (rank : 1383)	θ value	1.81305 (rank : 1399)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	59
SwissProt Accessions	Q12799	Gene names	TCP10, TCP10A
Domain Architecture
Description	T-complex protein 10A homolog.

CO1A1_MOUSE
NC score	0.025118 (rank : 1384)	θ value	0.21417 (rank : 1123)
Query Neighborhood Hits	1804	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

RUSC2_MOUSE
NC score	0.025042 (rank : 1385)	θ value	6.88961 (rank : 1706)
Query Neighborhood Hits	1804	Target Neighborhood Hits	305	Shared Neighborhood Hits	139
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

CAC1G_HUMAN
NC score	0.025040 (rank : 1386)	θ value	0.0961366 (rank : 1049)
Query Neighborhood Hits	1804	Target Neighborhood Hits	587	Shared Neighborhood Hits	242
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

NHS_HUMAN
NC score	0.024981 (rank : 1387)	θ value	3.0926 (rank : 1478)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	85
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

CARD6_HUMAN
NC score	0.024755 (rank : 1388)	θ value	0.0252991 (rank : 958)
Query Neighborhood Hits	1804	Target Neighborhood Hits	145	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

FBX41_MOUSE
NC score	0.024746 (rank : 1389)	θ value	0.163984 (rank : 1090)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

EP400_MOUSE
NC score	0.024682 (rank : 1390)	θ value	0.0148317 (rank : 929)
Query Neighborhood Hits	1804	Target Neighborhood Hits	592	Shared Neighborhood Hits	191
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

MUCDL_MOUSE
NC score	0.024606 (rank : 1391)	θ value	1.38821 (rank : 1337)
Query Neighborhood Hits	1804	Target Neighborhood Hits	461	Shared Neighborhood Hits	143
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SGIP1_MOUSE
NC score	0.024544 (rank : 1392)	θ value	4.03905 (rank : 1556)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	89
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

ICAL_HUMAN
NC score	0.024511 (rank : 1393)	θ value	1.06291 (rank : 1295)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	102
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

MAP2_MOUSE
NC score	0.024465 (rank : 1394)	θ value	8.99809 (rank : 1763)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	111
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

COIA1_HUMAN
NC score	0.024328 (rank : 1395)	θ value	0.0431538 (rank : 997)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	158
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CTND2_HUMAN
NC score	0.024246 (rank : 1396)	θ value	1.38821 (rank : 1326)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

SRCA_HUMAN
NC score	0.024182 (rank : 1397)	θ value	0.0431538 (rank : 1011)
Query Neighborhood Hits	1804	Target Neighborhood Hits	380	Shared Neighborhood Hits	123
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

OXR1_MOUSE
NC score	0.024091 (rank : 1398)	θ value	4.03905 (rank : 1544)
Query Neighborhood Hits	1804	Target Neighborhood Hits	516	Shared Neighborhood Hits	127
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

SMRC2_HUMAN
NC score	0.024073 (rank : 1399)	θ value	5.27518 (rank : 1633)
Query Neighborhood Hits	1804	Target Neighborhood Hits	499	Shared Neighborhood Hits	151
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

CXXC6_HUMAN
NC score	0.023763 (rank : 1400)	θ value	0.0193708 (rank : 946)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NFU7, Q5VUP7, Q7Z6B6, Q8TCR1, Q9C0I7	Gene names	CXXC6, KIAA1676, LCX
Domain Architecture	No domain graphic available
Description	CXXC-type zinc finger protein 6 (Leukemia-associated protein with a CXXC domain).

SC24D_HUMAN
NC score	0.023669 (rank : 1401)	θ value	0.163984 (rank : 1106)
Query Neighborhood Hits	1804	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	O94855	Gene names	SEC24D, KIAA0755
Domain Architecture
Description	Protein transport protein Sec24D (SEC24-related protein D).

ARHGF_HUMAN
NC score	0.023533 (rank : 1402)	θ value	0.21417 (rank : 1119)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	91
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NFRKB_HUMAN
NC score	0.023527 (rank : 1403)	θ value	4.03905 (rank : 1540)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	90
SwissProt Accessions	Q6P4R8, Q12869, Q15312, Q9H048	Gene names	NFRKB
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

ZYX_MOUSE
NC score	0.023385 (rank : 1404)	θ value	0.0736092 (rank : 1047)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	100
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

RFIP1_MOUSE
NC score	0.023335 (rank : 1405)	θ value	0.125558 (rank : 1080)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

SYNJ2_HUMAN
NC score	0.023311 (rank : 1406)	θ value	8.99809 (rank : 1790)
Query Neighborhood Hits	1804	Target Neighborhood Hits	136	Shared Neighborhood Hits	61
SwissProt Accessions	O15056, Q5TA13, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226	Gene names	SYNJ2, KIAA0348
Domain Architecture	No domain graphic available
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

CO3A1_MOUSE
NC score	0.023296 (rank : 1407)	θ value	0.163984 (rank : 1087)
Query Neighborhood Hits	1804	Target Neighborhood Hits	466	Shared Neighborhood Hits	152
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CUTL2_HUMAN
NC score	0.023296 (rank : 1408)	θ value	5.27518 (rank : 1589)
Query Neighborhood Hits	1804	Target Neighborhood Hits	906	Shared Neighborhood Hits	200
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CO1A1_HUMAN
NC score	0.023259 (rank : 1409)	θ value	0.365318 (rank : 1163)
Query Neighborhood Hits	1804	Target Neighborhood Hits	475	Shared Neighborhood Hits	145
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

MBB1A_MOUSE
NC score	0.023258 (rank : 1410)	θ value	5.27518 (rank : 1611)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

FMN1A_MOUSE
NC score	0.023249 (rank : 1411)	θ value	8.99809 (rank : 1743)
Query Neighborhood Hits	1804	Target Neighborhood Hits	423	Shared Neighborhood Hits	141
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

CCDC4_HUMAN
NC score	0.023219 (rank : 1412)	θ value	0.62314 (rank : 1224)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

COHA1_MOUSE
NC score	0.023174 (rank : 1413)	θ value	5.27518 (rank : 1587)
Query Neighborhood Hits	1804	Target Neighborhood Hits	414	Shared Neighborhood Hits	149
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CYTSA_MOUSE
NC score	0.023108 (rank : 1414)	θ value	1.38821 (rank : 1327)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1104	Shared Neighborhood Hits	149
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

ZYX_HUMAN
NC score	0.023104 (rank : 1415)	θ value	0.0431538 (rank : 1017)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	106
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ELOA3_HUMAN
NC score	0.022987 (rank : 1416)	θ value	0.365318 (rank : 1168)
Query Neighborhood Hits	1804	Target Neighborhood Hits	98	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

CSPG5_HUMAN
NC score	0.022955 (rank : 1417)	θ value	0.62314 (rank : 1226)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	82
SwissProt Accessions	O95196, Q71M39, Q71M40	Gene names	CSPG5, CALEB, NGC
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 5 precursor (Neuroglycan C) (Acidic leucine-rich EGF-like domain-containing brain protein).

ADDA_MOUSE
NC score	0.022904 (rank : 1418)	θ value	0.0563607 (rank : 1018)
Query Neighborhood Hits	1804	Target Neighborhood Hits	198	Shared Neighborhood Hits	103
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

TOIP2_MOUSE
NC score	0.022719 (rank : 1419)	θ value	0.000270298 (rank : 817)
Query Neighborhood Hits	1804	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYU6, Q6NY10, Q8BJP0	Gene names	Tor1aip2
Domain Architecture	No domain graphic available
Description	Torsin-1A-interacting protein 2.

BCOR_HUMAN
NC score	0.022537 (rank : 1420)	θ value	4.03905 (rank : 1500)
Query Neighborhood Hits	1804	Target Neighborhood Hits	609	Shared Neighborhood Hits	168
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

SYTL1_HUMAN
NC score	0.022497 (rank : 1421)	θ value	4.03905 (rank : 1561)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYJ3, Q96BB6, Q96GU6, Q96S89, Q96SI0	Gene names	SYTL1, SLP1
Domain Architecture
Description	Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) (SB146).

VINEX_MOUSE
NC score	0.022432 (rank : 1422)	θ value	2.36792 (rank : 1446)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

IQEC2_HUMAN
NC score	0.022363 (rank : 1423)	θ value	0.0736092 (rank : 1033)
Query Neighborhood Hits	1804	Target Neighborhood Hits	403	Shared Neighborhood Hits	134
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

PDC6I_MOUSE
NC score	0.022309 (rank : 1424)	θ value	0.47712 (rank : 1204)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	92
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

RFIP4_MOUSE
NC score	0.022285 (rank : 1425)	θ value	1.81305 (rank : 1390)
Query Neighborhood Hits	1804	Target Neighborhood Hits	708	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

HCN2_MOUSE
NC score	0.022170 (rank : 1426)	θ value	8.99809 (rank : 1750)
Query Neighborhood Hits	1804	Target Neighborhood Hits	278	Shared Neighborhood Hits	130
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

RIN3_HUMAN
NC score	0.021919 (rank : 1427)	θ value	0.279714 (rank : 1157)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	99
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

SNIP_MOUSE
NC score	0.021858 (rank : 1428)	θ value	8.99809 (rank : 1788)
Query Neighborhood Hits	1804	Target Neighborhood Hits	319	Shared Neighborhood Hits	109
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

IQEC2_MOUSE
NC score	0.021782 (rank : 1429)	θ value	0.0736092 (rank : 1034)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	139
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

CO4A4_HUMAN
NC score	0.021752 (rank : 1430)	θ value	0.00665767 (rank : 889)
Query Neighborhood Hits	1804	Target Neighborhood Hits	440	Shared Neighborhood Hits	136
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

RTN1_MOUSE
NC score	0.021483 (rank : 1431)	θ value	0.21417 (rank : 1133)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	91
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

YTDC1_HUMAN
NC score	0.021476 (rank : 1432)	θ value	2.36792 (rank : 1447)
Query Neighborhood Hits	1804	Target Neighborhood Hits	458	Shared Neighborhood Hits	108
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

JIP1_MOUSE
NC score	0.021419 (rank : 1433)	θ value	5.27518 (rank : 1603)
Query Neighborhood Hits	1804	Target Neighborhood Hits	259	Shared Neighborhood Hits	118
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

PHF20_MOUSE
NC score	0.021368 (rank : 1434)	θ value	6.88961 (rank : 1697)
Query Neighborhood Hits	1804	Target Neighborhood Hits	513	Shared Neighborhood Hits	125
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

ES8L1_HUMAN
NC score	0.021258 (rank : 1435)	θ value	5.27518 (rank : 1594)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

CO5A2_HUMAN
NC score	0.021208 (rank : 1436)	θ value	2.36792 (rank : 1418)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	218
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

PP1RA_MOUSE
NC score	0.021054 (rank : 1437)	θ value	0.365318 (rank : 1181)
Query Neighborhood Hits	1804	Target Neighborhood Hits	175	Shared Neighborhood Hits	76
SwissProt Accessions	Q80W00, Q811B6, Q8C6T7, Q8K2U8	Gene names	Ppp1r10, Cat53
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53).

K1688_HUMAN
NC score	0.021041 (rank : 1438)	θ value	0.279714 (rank : 1151)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	96
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

ARI5B_HUMAN
NC score	0.021036 (rank : 1439)	θ value	5.27518 (rank : 1573)
Query Neighborhood Hits	1804	Target Neighborhood Hits	328	Shared Neighborhood Hits	109
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

FMN1B_MOUSE
NC score	0.020972 (rank : 1440)	θ value	5.27518 (rank : 1595)
Query Neighborhood Hits	1804	Target Neighborhood Hits	447	Shared Neighborhood Hits	148
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

LRIG1_MOUSE
NC score	0.020934 (rank : 1441)	θ value	0.0148317 (rank : 932)
Query Neighborhood Hits	1804	Target Neighborhood Hits	627	Shared Neighborhood Hits	68
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

HSF1_MOUSE
NC score	0.020925 (rank : 1442)	θ value	8.99809 (rank : 1751)
Query Neighborhood Hits	1804	Target Neighborhood Hits	267	Shared Neighborhood Hits	124
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

EP400_HUMAN
NC score	0.020889 (rank : 1443)	θ value	0.279714 (rank : 1148)
Query Neighborhood Hits	1804	Target Neighborhood Hits	556	Shared Neighborhood Hits	180
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

3BP1_HUMAN
NC score	0.020876 (rank : 1444)	θ value	3.0926 (rank : 1450)
Query Neighborhood Hits	1804	Target Neighborhood Hits	376	Shared Neighborhood Hits	150
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TF3C2_HUMAN
NC score	0.020839 (rank : 1445)	θ value	0.0148317 (rank : 936)
Query Neighborhood Hits	1804	Target Neighborhood Hits	168	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

IF4G1_HUMAN
NC score	0.020812 (rank : 1446)	θ value	5.27518 (rank : 1598)
Query Neighborhood Hits	1804	Target Neighborhood Hits	347	Shared Neighborhood Hits	151
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

TTC28_HUMAN
NC score	0.020726 (rank : 1447)	θ value	0.0252991 (rank : 969)
Query Neighborhood Hits	1804	Target Neighborhood Hits	271	Shared Neighborhood Hits	94
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

K0528_MOUSE
NC score	0.020577 (rank : 1448)	θ value	0.813845 (rank : 1264)
Query Neighborhood Hits	1804	Target Neighborhood Hits	102	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TPS5, Q3TQY6, Q6A052, Q80VA1, Q8C0U3, Q8CID5, Q9CS85	Gene names	Kiaa0528
Domain Architecture	No domain graphic available
Description	Protein KIAA0528.

SYT4_HUMAN
NC score	0.020547 (rank : 1449)	θ value	0.00665767 (rank : 898)
Query Neighborhood Hits	1804	Target Neighborhood Hits	121	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

UBN1_HUMAN
NC score	0.020476 (rank : 1450)	θ value	0.62314 (rank : 1253)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

RUNX3_MOUSE
NC score	0.020422 (rank : 1451)	θ value	6.88961 (rank : 1705)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	50
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

ATRX_MOUSE
NC score	0.020223 (rank : 1452)	θ value	6.88961 (rank : 1652)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	146
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

CO7A1_HUMAN
NC score	0.020165 (rank : 1453)	θ value	0.21417 (rank : 1124)
Query Neighborhood Hits	1804	Target Neighborhood Hits	807	Shared Neighborhood Hits	217
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

RANB9_HUMAN
NC score	0.020072 (rank : 1454)	θ value	0.47712 (rank : 1205)
Query Neighborhood Hits	1804	Target Neighborhood Hits	179	Shared Neighborhood Hits	81
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

HNRL1_MOUSE
NC score	0.019989 (rank : 1455)	θ value	0.21417 (rank : 1126)
Query Neighborhood Hits	1804	Target Neighborhood Hits	200	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

CITE4_HUMAN
NC score	0.019968 (rank : 1456)	θ value	1.38821 (rank : 1325)
Query Neighborhood Hits	1804	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q96RK1	Gene names	CITED4, MRG2
Domain Architecture	No domain graphic available
Description	Cbp/p300-interacting transactivator 4 (MSG1-related protein 2) (MRG- 2).

ZN541_HUMAN
NC score	0.019947 (rank : 1457)	θ value	4.03905 (rank : 1569)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	74
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

BRDT_MOUSE
NC score	0.019839 (rank : 1458)	θ value	0.0113563 (rank : 910)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	68
SwissProt Accessions	Q91Y44, Q59HJ4	Gene names	Brdt, Fsrg3
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein) (Bromodomain- containing female sterile homeotic-like protein).

IQEC3_MOUSE
NC score	0.019807 (rank : 1459)	θ value	0.279714 (rank : 1150)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	112
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

CTDP1_MOUSE
NC score	0.019721 (rank : 1460)	θ value	0.0961366 (rank : 1051)
Query Neighborhood Hits	1804	Target Neighborhood Hits	146	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

CTR9_MOUSE
NC score	0.019571 (rank : 1461)	θ value	0.125558 (rank : 1068)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	86
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

BIN1_MOUSE
NC score	0.019512 (rank : 1462)	θ value	0.47712 (rank : 1192)
Query Neighborhood Hits	1804	Target Neighborhood Hits	283	Shared Neighborhood Hits	91
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

PTN23_MOUSE
NC score	0.019504 (rank : 1463)	θ value	1.38821 (rank : 1343)
Query Neighborhood Hits	1804	Target Neighborhood Hits	726	Shared Neighborhood Hits	221
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

HNRL1_HUMAN
NC score	0.019463 (rank : 1464)	θ value	0.163984 (rank : 1094)
Query Neighborhood Hits	1804	Target Neighborhood Hits	173	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

TR150_HUMAN
NC score	0.019235 (rank : 1465)	θ value	2.36792 (rank : 1444)
Query Neighborhood Hits	1804	Target Neighborhood Hits	313	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y2W1, Q5VTK6	Gene names	THRAP3, TRAP150
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150).

ZIM10_MOUSE
NC score	0.019180 (rank : 1466)	θ value	5.27518 (rank : 1649)
Query Neighborhood Hits	1804	Target Neighborhood Hits	430	Shared Neighborhood Hits	169
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ANR25_MOUSE
NC score	0.019111 (rank : 1467)	θ value	0.365318 (rank : 1161)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	99
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

GAB2_MOUSE
NC score	0.019086 (rank : 1468)	θ value	0.62314 (rank : 1229)
Query Neighborhood Hits	1804	Target Neighborhood Hits	220	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GFC1_HUMAN
NC score	0.019072 (rank : 1469)	θ value	0.0148317 (rank : 930)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	37
SwissProt Accessions	P63117	Gene names
Domain Architecture	No domain graphic available
Description	HERV-F(c)1_Xq21.33 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein].

CNGB3_HUMAN
NC score	0.019028 (rank : 1470)	θ value	4.03905 (rank : 1506)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

RUNX3_HUMAN
NC score	0.018979 (rank : 1471)	θ value	0.47712 (rank : 1206)
Query Neighborhood Hits	1804	Target Neighborhood Hits	96	Shared Neighborhood Hits	45
SwissProt Accessions	Q13761, Q12969, Q13760	Gene names	RUNX3, AML2, CBFA3, PEBP2A3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

FMN2_MOUSE
NC score	0.018948 (rank : 1472)	θ value	1.81305 (rank : 1367)
Query Neighborhood Hits	1804	Target Neighborhood Hits	349	Shared Neighborhood Hits	126
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

MAML1_HUMAN
NC score	0.018864 (rank : 1473)	θ value	5.27518 (rank : 1610)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	100
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

TF3C2_MOUSE
NC score	0.018806 (rank : 1474)	θ value	0.0252991 (rank : 968)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

BCAR3_MOUSE
NC score	0.018799 (rank : 1475)	θ value	1.81305 (rank : 1358)
Query Neighborhood Hits	1804	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

ERCC5_MOUSE
NC score	0.018774 (rank : 1476)	θ value	0.365318 (rank : 1169)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	66
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

PSD4_HUMAN
NC score	0.018747 (rank : 1477)	θ value	0.0148317 (rank : 934)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

CF155_HUMAN
NC score	0.018631 (rank : 1478)	θ value	2.36792 (rank : 1411)
Query Neighborhood Hits	1804	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

TNR6A_HUMAN
NC score	0.018611 (rank : 1479)	θ value	3.0926 (rank : 1491)
Query Neighborhood Hits	1804	Target Neighborhood Hits	343	Shared Neighborhood Hits	109
SwissProt Accessions	Q8NDV7, O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0, Q9NV59, Q9P268	Gene names	TNRC6A, CAGH26, KIAA1460, TNRC6
Domain Architecture	No domain graphic available
Description	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (Glycine-tryptophan protein of 182 kDa) (GW182 autoantigen) (Protein GW1) (EMSY interactor protein).

SAM14_HUMAN
NC score	0.018590 (rank : 1480)	θ value	0.47712 (rank : 1208)
Query Neighborhood Hits	1804	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IZD0, Q8N2X0	Gene names	SAMD14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

SIA7A_HUMAN
NC score	0.018543 (rank : 1481)	θ value	0.813845 (rank : 1269)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NSC7, Q6UW90, Q9NSC6	Gene names	ST6GALNAC1, SIAT7A
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

SAM14_MOUSE
NC score	0.018406 (rank : 1482)	θ value	0.47712 (rank : 1209)
Query Neighborhood Hits	1804	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K070, Q5SWB7, Q8BHE2, Q8C8N5	Gene names	Samd14
Domain Architecture	No domain graphic available
Description	Sterile alpha motif domain-containing protein 14.

PYGO2_HUMAN
NC score	0.018404 (rank : 1483)	θ value	2.36792 (rank : 1437)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	87
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

TRIPC_HUMAN
NC score	0.018238 (rank : 1484)	θ value	0.0431538 (rank : 1015)
Query Neighborhood Hits	1804	Target Neighborhood Hits	319	Shared Neighborhood Hits	101
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

BRD3_HUMAN
NC score	0.018056 (rank : 1485)	θ value	8.99809 (rank : 1729)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	105
SwissProt Accessions	Q15059, Q5T1R7, Q8N5M3, Q92645	Gene names	BRD3, KIAA0043, RING3L
Domain Architecture
Description	Bromodomain-containing protein 3 (RING3-like protein).

TNKS1_HUMAN
NC score	0.017972 (rank : 1486)	θ value	8.99809 (rank : 1794)
Query Neighborhood Hits	1804	Target Neighborhood Hits	477	Shared Neighborhood Hits	110
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

GASP2_MOUSE
NC score	0.017900 (rank : 1487)	θ value	1.38821 (rank : 1329)
Query Neighborhood Hits	1804	Target Neighborhood Hits	228	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

NCOA5_HUMAN
NC score	0.017724 (rank : 1488)	θ value	5.27518 (rank : 1614)
Query Neighborhood Hits	1804	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HCD5, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9	Gene names	NCOA5, KIAA1637
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

H15_HUMAN
NC score	0.017711 (rank : 1489)	θ value	0.125558 (rank : 1070)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	P16401, Q14529	Gene names	HIST1H1B, H1F5
Domain Architecture
Description	Histone H1.5 (Histone H1a).

PKHA4_HUMAN
NC score	0.017654 (rank : 1490)	θ value	1.06291 (rank : 1300)
Query Neighborhood Hits	1804	Target Neighborhood Hits	283	Shared Neighborhood Hits	101
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CEND3_HUMAN
NC score	0.017616 (rank : 1491)	θ value	0.0113563 (rank : 911)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CSF1_MOUSE
NC score	0.017607 (rank : 1492)	θ value	0.813845 (rank : 1258)
Query Neighborhood Hits	1804	Target Neighborhood Hits	83	Shared Neighborhood Hits	46
SwissProt Accessions	P07141, Q8R3C8	Gene names	Csf1, Csfm
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF).

DVL2_MOUSE
NC score	0.017557 (rank : 1493)	θ value	6.88961 (rank : 1671)
Query Neighborhood Hits	1804	Target Neighborhood Hits	233	Shared Neighborhood Hits	125
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

SYBU_MOUSE
NC score	0.017544 (rank : 1494)	θ value	1.81305 (rank : 1397)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BHS8, Q3TQN7, Q401F3, Q401F4, Q571C1, Q6P1J2, Q80XH0, Q8BHS7, Q8BI27	Gene names	Sybu, Golsyn, Kiaa1472
Domain Architecture	No domain graphic available
Description	Syntabulin (Syntaxin-1-binding protein) (Golgi-localized syntaphilin- related protein) (m-Golsyn).

ABI3_MOUSE
NC score	0.017457 (rank : 1495)	θ value	8.99809 (rank : 1722)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

REV1_MOUSE
NC score	0.017403 (rank : 1496)	θ value	0.00390308 (rank : 876)
Query Neighborhood Hits	1804	Target Neighborhood Hits	67	Shared Neighborhood Hits	31
SwissProt Accessions	Q920Q2, Q9QXV2	Gene names	Rev1l, Rev1
Domain Architecture	No domain graphic available
Description	DNA repair protein REV1 (EC 2.7.7.-) (Rev1-like terminal deoxycytidyl transferase).

PHC2_MOUSE
NC score	0.017321 (rank : 1497)	θ value	3.0926 (rank : 1481)
Query Neighborhood Hits	1804	Target Neighborhood Hits	156	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QWH1, O88463, Q8K5D9	Gene names	Phc2, Edr2, Ph2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36).

SYGP1_HUMAN
NC score	0.017298 (rank : 1498)	θ value	0.365318 (rank : 1184)
Query Neighborhood Hits	1804	Target Neighborhood Hits	589	Shared Neighborhood Hits	88
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

ZN598_HUMAN
NC score	0.017210 (rank : 1499)	θ value	3.0926 (rank : 1495)
Query Neighborhood Hits	1804	Target Neighborhood Hits	339	Shared Neighborhood Hits	86
SwissProt Accessions	Q86UK7, Q8IW49, Q8N3D9, Q96FG3, Q9H7J3	Gene names	ZNF598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

CO5A1_HUMAN
NC score	0.017205 (rank : 1500)	θ value	2.36792 (rank : 1416)
Query Neighborhood Hits	1804	Target Neighborhood Hits	434	Shared Neighborhood Hits	151
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

IKBE_HUMAN
NC score	0.017126 (rank : 1501)	θ value	0.21417 (rank : 1127)
Query Neighborhood Hits	1804	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

NOS1_HUMAN
NC score	0.017075 (rank : 1502)	θ value	6.88961 (rank : 1691)
Query Neighborhood Hits	1804	Target Neighborhood Hits	218	Shared Neighborhood Hits	120
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

ZIMP7_HUMAN
NC score	0.016957 (rank : 1503)	θ value	0.125558 (rank : 1083)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	110
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

REXO1_MOUSE
NC score	0.016931 (rank : 1504)	θ value	5.27518 (rank : 1627)
Query Neighborhood Hits	1804	Target Neighborhood Hits	166	Shared Neighborhood Hits	73
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

CKAP4_HUMAN
NC score	0.016588 (rank : 1505)	θ value	1.06291 (rank : 1287)
Query Neighborhood Hits	1804	Target Neighborhood Hits	592	Shared Neighborhood Hits	61
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

H14_MOUSE
NC score	0.016572 (rank : 1506)	θ value	0.47712 (rank : 1199)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	P43274	Gene names	Hist1h1e, H1f4
Domain Architecture
Description	Histone H1.4 (H1 VAR.2) (H1e).

CO5A1_MOUSE
NC score	0.016568 (rank : 1507)	θ value	2.36792 (rank : 1417)
Query Neighborhood Hits	1804	Target Neighborhood Hits	419	Shared Neighborhood Hits	140
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

MKL2_HUMAN
NC score	0.016556 (rank : 1508)	θ value	4.03905 (rank : 1536)
Query Neighborhood Hits	1804	Target Neighborhood Hits	274	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ULH7, Q68CT1, Q6UB16, Q86WW2, Q8N226	Gene names	MKL2, KIAA1243, MRTFB
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B) (Megakaryoblastic leukemia 2).

BCL7C_MOUSE
NC score	0.016553 (rank : 1509)	θ value	0.163984 (rank : 1086)
Query Neighborhood Hits	1804	Target Neighborhood Hits	170	Shared Neighborhood Hits	69
SwissProt Accessions	O08664, Q99LS2	Gene names	Bcl7c
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member C (B-cell chronic lymphocytic leukemia/lymphoma 7C protein).

CO2A1_HUMAN
NC score	0.016525 (rank : 1510)	θ value	2.36792 (rank : 1414)
Query Neighborhood Hits	1804	Target Neighborhood Hits	486	Shared Neighborhood Hits	149
SwissProt Accessions	P02458, Q12985, Q14009, Q14044, Q14046, Q14056, Q14058, Q16672, Q6LBY1, Q6LBY2, Q6LBY3, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43	Gene names	COL2A1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

NU153_HUMAN
NC score	0.016510 (rank : 1511)	θ value	6.88961 (rank : 1693)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

NFAC1_HUMAN
NC score	0.016503 (rank : 1512)	θ value	5.27518 (rank : 1615)
Query Neighborhood Hits	1804	Target Neighborhood Hits	312	Shared Neighborhood Hits	140
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

WBS14_MOUSE
NC score	0.016423 (rank : 1513)	θ value	1.06291 (rank : 1317)
Query Neighborhood Hits	1804	Target Neighborhood Hits	171	Shared Neighborhood Hits	66
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

PRCC_HUMAN
NC score	0.016411 (rank : 1514)	θ value	1.81305 (rank : 1389)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	43
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

TRI66_MOUSE
NC score	0.016398 (rank : 1515)	θ value	8.99809 (rank : 1797)
Query Neighborhood Hits	1804	Target Neighborhood Hits	491	Shared Neighborhood Hits	133
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ZN703_HUMAN
NC score	0.016396 (rank : 1516)	θ value	0.813845 (rank : 1278)
Query Neighborhood Hits	1804	Target Neighborhood Hits	154	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

CDN1C_MOUSE
NC score	0.016310 (rank : 1517)	θ value	3.0926 (rank : 1460)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

NCOA5_MOUSE
NC score	0.016249 (rank : 1518)	θ value	1.38821 (rank : 1338)
Query Neighborhood Hits	1804	Target Neighborhood Hits	87	Shared Neighborhood Hits	40
SwissProt Accessions	Q91W39	Gene names	Ncoa5
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA).

ZAN_HUMAN
NC score	0.016098 (rank : 1519)	θ value	0.00298849 (rank : 869)
Query Neighborhood Hits	1804	Target Neighborhood Hits	679	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ARMX2_HUMAN
NC score	0.016055 (rank : 1520)	θ value	0.279714 (rank : 1141)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	53
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

COIA1_MOUSE
NC score	0.016012 (rank : 1521)	θ value	6.88961 (rank : 1664)
Query Neighborhood Hits	1804	Target Neighborhood Hits	481	Shared Neighborhood Hits	150
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

NFAC4_HUMAN
NC score	0.015927 (rank : 1522)	θ value	0.21417 (rank : 1131)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	64
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

MYPT1_MOUSE
NC score	0.015679 (rank : 1523)	θ value	4.03905 (rank : 1538)
Query Neighborhood Hits	1804	Target Neighborhood Hits	539	Shared Neighborhood Hits	99
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

CO4A1_MOUSE
NC score	0.015619 (rank : 1524)	θ value	2.36792 (rank : 1415)
Query Neighborhood Hits	1804	Target Neighborhood Hits	450	Shared Neighborhood Hits	142
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

UBP42_HUMAN
NC score	0.015615 (rank : 1525)	θ value	0.813845 (rank : 1274)
Query Neighborhood Hits	1804	Target Neighborhood Hits	445	Shared Neighborhood Hits	153
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

COBA2_MOUSE
NC score	0.015560 (rank : 1526)	θ value	1.06291 (rank : 1290)
Query Neighborhood Hits	1804	Target Neighborhood Hits	501	Shared Neighborhood Hits	151
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

LYAR_HUMAN
NC score	0.015551 (rank : 1527)	θ value	5.27518 (rank : 1609)
Query Neighborhood Hits	1804	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NX58, Q6FI78, Q9NYS1	Gene names	LYAR
Domain Architecture	No domain graphic available
Description	Cell growth-regulating nucleolar protein.

DAB2P_HUMAN
NC score	0.015478 (rank : 1528)	θ value	1.06291 (rank : 1292)
Query Neighborhood Hits	1804	Target Neighborhood Hits	303	Shared Neighborhood Hits	62
SwissProt Accessions	Q5VWQ8, Q8TDL2, Q96SE1, Q9C0C0	Gene names	DAB2IP, AF9Q34, AIP1, KIAA1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein) (DAB2 interaction protein) (ASK-interacting protein 1).

K1949_MOUSE
NC score	0.015434 (rank : 1529)	θ value	0.813845 (rank : 1265)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

AF17_HUMAN
NC score	0.015091 (rank : 1530)	θ value	0.62314 (rank : 1221)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	83
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

UBP31_HUMAN
NC score	0.015005 (rank : 1531)	θ value	1.81305 (rank : 1401)
Query Neighborhood Hits	1804	Target Neighborhood Hits	293	Shared Neighborhood Hits	113
SwissProt Accessions	Q70CQ4, Q6AW97, Q6ZTC0, Q6ZTN2, Q9ULL7	Gene names	USP31, KIAA1203
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 31 (EC 3.1.2.15) (Ubiquitin thioesterase 31) (Ubiquitin-specific-processing protease 31) (Deubiquitinating enzyme 31).

MYCB2_MOUSE
NC score	0.014999 (rank : 1532)	θ value	8.99809 (rank : 1768)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

COBA2_HUMAN
NC score	0.014942 (rank : 1533)	θ value	1.06291 (rank : 1289)
Query Neighborhood Hits	1804	Target Neighborhood Hits	408	Shared Neighborhood Hits	125
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

ZMYM3_HUMAN
NC score	0.014911 (rank : 1534)	θ value	0.62314 (rank : 1254)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	69
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

H15_MOUSE
NC score	0.014885 (rank : 1535)	θ value	4.03905 (rank : 1520)
Query Neighborhood Hits	1804	Target Neighborhood Hits	79	Shared Neighborhood Hits	42
SwissProt Accessions	P43276, Q9CRM8	Gene names	Hist1h1b, H1f5
Domain Architecture
Description	Histone H1.5 (H1 VAR.5) (H1b).

RUSC1_MOUSE
NC score	0.014815 (rank : 1536)	θ value	1.38821 (rank : 1346)
Query Neighborhood Hits	1804	Target Neighborhood Hits	206	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

DAXX_HUMAN
NC score	0.014711 (rank : 1537)	θ value	1.06291 (rank : 1293)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

BAP1_MOUSE
NC score	0.014687 (rank : 1538)	θ value	5.27518 (rank : 1580)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	65
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

SOX6_MOUSE
NC score	0.014655 (rank : 1539)	θ value	1.81305 (rank : 1395)
Query Neighborhood Hits	1804	Target Neighborhood Hits	341	Shared Neighborhood Hits	93
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

DAB2P_MOUSE
NC score	0.014620 (rank : 1540)	θ value	0.279714 (rank : 1144)
Query Neighborhood Hits	1804	Target Neighborhood Hits	284	Shared Neighborhood Hits	47
SwissProt Accessions	Q3UHC7, Q3TPD5, Q3UH44, Q6JTV1, Q80T97	Gene names	Dab2ip, Kiaa1743
Domain Architecture	No domain graphic available
Description	Disabled homolog 2-interacting protein (DAB2-interacting protein).

CP053_MOUSE
NC score	0.014597 (rank : 1541)	θ value	0.279714 (rank : 1142)
Query Neighborhood Hits	1804	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q99L02	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53 homolog.

SOX6_HUMAN
NC score	0.014595 (rank : 1542)	θ value	0.62314 (rank : 1250)
Query Neighborhood Hits	1804	Target Neighborhood Hits	332	Shared Neighborhood Hits	95
SwissProt Accessions	P35712, Q9BXQ3, Q9BXQ4, Q9BXQ5, Q9H0I8	Gene names	SOX6
Domain Architecture
Description	Transcription factor SOX-6.

ASXL1_MOUSE
NC score	0.014543 (rank : 1543)	θ value	5.27518 (rank : 1576)
Query Neighborhood Hits	1804	Target Neighborhood Hits	182	Shared Neighborhood Hits	70
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

TNC6B_HUMAN
NC score	0.014517 (rank : 1544)	θ value	3.0926 (rank : 1490)
Query Neighborhood Hits	1804	Target Neighborhood Hits	256	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

GLU2B_HUMAN
NC score	0.014512 (rank : 1545)	θ value	6.88961 (rank : 1677)
Query Neighborhood Hits	1804	Target Neighborhood Hits	377	Shared Neighborhood Hits	73
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

COBA1_MOUSE
NC score	0.014372 (rank : 1546)	θ value	0.47712 (rank : 1194)
Query Neighborhood Hits	1804	Target Neighborhood Hits	487	Shared Neighborhood Hits	144
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

JPH2_MOUSE
NC score	0.014344 (rank : 1547)	θ value	4.03905 (rank : 1524)
Query Neighborhood Hits	1804	Target Neighborhood Hits	279	Shared Neighborhood Hits	124
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CO2A1_MOUSE
NC score	0.014203 (rank : 1548)	θ value	0.0961366 (rank : 1050)
Query Neighborhood Hits	1804	Target Neighborhood Hits	483	Shared Neighborhood Hits	132
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

HOME1_MOUSE
NC score	0.014174 (rank : 1549)	θ value	6.88961 (rank : 1679)
Query Neighborhood Hits	1804	Target Neighborhood Hits	630	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

COBA1_HUMAN
NC score	0.014083 (rank : 1550)	θ value	5.27518 (rank : 1586)
Query Neighborhood Hits	1804	Target Neighborhood Hits	491	Shared Neighborhood Hits	140
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

DAB2_MOUSE
NC score	0.013977 (rank : 1551)	θ value	8.99809 (rank : 1739)
Query Neighborhood Hits	1804	Target Neighborhood Hits	163	Shared Neighborhood Hits	72
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

CTND2_MOUSE
NC score	0.013893 (rank : 1552)	θ value	1.06291 (rank : 1291)
Query Neighborhood Hits	1804	Target Neighborhood Hits	227	Shared Neighborhood Hits	93
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

CD248_MOUSE
NC score	0.013879 (rank : 1553)	θ value	2.36792 (rank : 1410)
Query Neighborhood Hits	1804	Target Neighborhood Hits	578	Shared Neighborhood Hits	176
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

TMM29_HUMAN
NC score	0.013822 (rank : 1554)	θ value	8.99809 (rank : 1793)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	22
SwissProt Accessions	Q8NDB6, Q5JPL2, Q5JPL3, Q5JPL4, Q5JPL5, Q5JPL6, Q68D17, Q6NVY3, Q9UI49	Gene names	TMEM29
Domain Architecture	No domain graphic available
Description	Transmembrane protein 29.

SMRC1_MOUSE
NC score	0.013769 (rank : 1555)	θ value	8.99809 (rank : 1787)
Query Neighborhood Hits	1804	Target Neighborhood Hits	459	Shared Neighborhood Hits	138
SwissProt Accessions	P97496, Q7TS80, Q7TT29	Gene names	Smarcc1, Baf155, Srg3
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155) (SWI3-related protein).

TAF6_HUMAN
NC score	0.013761 (rank : 1556)	θ value	8.99809 (rank : 1791)
Query Neighborhood Hits	1804	Target Neighborhood Hits	127	Shared Neighborhood Hits	53
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

MYST4_HUMAN
NC score	0.013671 (rank : 1557)	θ value	2.36792 (rank : 1434)
Query Neighborhood Hits	1804	Target Neighborhood Hits	671	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

LSD1_MOUSE
NC score	0.013659 (rank : 1558)	θ value	1.06291 (rank : 1297)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZQ88, Q6PB53, Q8VEA1	Gene names	Aof2, Kiaa0601, Lsd1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

COAA1_HUMAN
NC score	0.013653 (rank : 1559)	θ value	1.81305 (rank : 1365)
Query Neighborhood Hits	1804	Target Neighborhood Hits	316	Shared Neighborhood Hits	109
SwissProt Accessions	Q03692	Gene names	COL10A1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

EHMT1_HUMAN
NC score	0.013619 (rank : 1560)	θ value	8.99809 (rank : 1742)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	76
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

SMG5_HUMAN
NC score	0.013459 (rank : 1561)	θ value	0.813845 (rank : 1271)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UPR3, Q5QJE7, Q8IXC0, Q8IY09, Q96IJ7	Gene names	SMG5, EST1B, KIAA1089
Domain Architecture	No domain graphic available
Description	Protein SMG5 (SMG-5 homolog) (EST1-like protein B) (LPTS-interacting protein) (LPTS-RP1).

BAP1_HUMAN
NC score	0.013449 (rank : 1562)	θ value	5.27518 (rank : 1579)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	56
SwissProt Accessions	Q92560, Q6LEM0, Q7Z5E8	Gene names	BAP1, KIAA0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Cerebral protein 6).

ADDA_HUMAN
NC score	0.013431 (rank : 1563)	θ value	0.21417 (rank : 1118)
Query Neighborhood Hits	1804	Target Neighborhood Hits	108	Shared Neighborhood Hits	43
SwissProt Accessions	P35611, Q13734, Q14729, Q16156, Q9UJB6	Gene names	ADD1, ADDA
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

CDT1_MOUSE
NC score	0.013403 (rank : 1564)	θ value	4.03905 (rank : 1503)
Query Neighborhood Hits	1804	Target Neighborhood Hits	72	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

SMC4_HUMAN
NC score	0.013289 (rank : 1565)	θ value	8.99809 (rank : 1785)
Query Neighborhood Hits	1804	Target Neighborhood Hits	937	Shared Neighborhood Hits	112
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CO4A2_MOUSE
NC score	0.013074 (rank : 1566)	θ value	5.27518 (rank : 1584)
Query Neighborhood Hits	1804	Target Neighborhood Hits	492	Shared Neighborhood Hits	148
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

PAIP1_HUMAN
NC score	0.012986 (rank : 1567)	θ value	1.38821 (rank : 1340)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

FGD1_MOUSE
NC score	0.012984 (rank : 1568)	θ value	2.36792 (rank : 1425)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	119
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

H13_HUMAN
NC score	0.012872 (rank : 1569)	θ value	8.99809 (rank : 1749)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	33
SwissProt Accessions	P16402	Gene names	HIST1H1D, H1F3
Domain Architecture
Description	Histone H1.3 (Histone H1c).

XPC_MOUSE
NC score	0.012843 (rank : 1570)	θ value	0.21417 (rank : 1138)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	P51612, P54732, Q3TKI2, Q920M1, Q9DBW7	Gene names	Xpc
Domain Architecture
Description	DNA-repair protein complementing XP-C cells homolog (Xeroderma pigmentosum group C-complementing protein homolog) (p125).

CO4A1_HUMAN
NC score	0.012779 (rank : 1571)	θ value	4.03905 (rank : 1508)
Query Neighborhood Hits	1804	Target Neighborhood Hits	425	Shared Neighborhood Hits	128
SwissProt Accessions	P02462	Gene names	COL4A1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

HDAC9_MOUSE
NC score	0.012739 (rank : 1572)	θ value	6.88961 (rank : 1678)
Query Neighborhood Hits	1804	Target Neighborhood Hits	186	Shared Neighborhood Hits	36
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

CCD1A_MOUSE
NC score	0.012660 (rank : 1573)	θ value	0.21417 (rank : 1121)
Query Neighborhood Hits	1804	Target Neighborhood Hits	83	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K1A6, Q2MJB5, Q8R3Z4	Gene names	Cc2d1a
Domain Architecture	No domain graphic available
Description	Coiled-coil and C2 domain-containing protein 1A (Five repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1).

MAGC1_HUMAN
NC score	0.012485 (rank : 1574)	θ value	4.03905 (rank : 1534)
Query Neighborhood Hits	1804	Target Neighborhood Hits	431	Shared Neighborhood Hits	172
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

SRGP1_HUMAN
NC score	0.012462 (rank : 1575)	θ value	1.38821 (rank : 1350)
Query Neighborhood Hits	1804	Target Neighborhood Hits	390	Shared Neighborhood Hits	84
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SIA7A_MOUSE
NC score	0.012292 (rank : 1576)	θ value	5.27518 (rank : 1632)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

CN004_HUMAN
NC score	0.012286 (rank : 1577)	θ value	6.88961 (rank : 1660)
Query Neighborhood Hits	1804	Target Neighborhood Hits	108	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

P66A_HUMAN
NC score	0.012269 (rank : 1578)	θ value	4.03905 (rank : 1545)
Query Neighborhood Hits	1804	Target Neighborhood Hits	111	Shared Neighborhood Hits	45
SwissProt Accessions	Q86YP4, Q7L3J2, Q96F28, Q9NPU2, Q9NXS1	Gene names	GATAD2A
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A).

RD23B_MOUSE
NC score	0.012034 (rank : 1579)	θ value	8.99809 (rank : 1776)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	70
SwissProt Accessions	P54728	Gene names	Rad23b, Mhr23b
Domain Architecture
Description	UV excision repair protein RAD23 homolog B (mHR23B) (XP-C repair- complementing complex 58 kDa protein) (p58).

MORC2_HUMAN
NC score	0.011987 (rank : 1580)	θ value	3.0926 (rank : 1474)
Query Neighborhood Hits	1804	Target Neighborhood Hits	207	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y6X9, Q9UF28, Q9Y6V2	Gene names	MORC2, KIAA0852, ZCWCC1
Domain Architecture
Description	MORC family CW-type zinc finger protein 2 (Zinc finger CW-type coiled- coil domain protein 1).

SMBP2_MOUSE
NC score	0.011767 (rank : 1581)	θ value	0.0736092 (rank : 1045)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

ZCH10_HUMAN
NC score	0.011736 (rank : 1582)	θ value	6.88961 (rank : 1717)
Query Neighborhood Hits	1804	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TBK6, Q9NXR4	Gene names	ZCCHC10
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 10.

NKTR_MOUSE
NC score	0.011693 (rank : 1583)	θ value	1.81305 (rank : 1380)
Query Neighborhood Hits	1804	Target Neighborhood Hits	417	Shared Neighborhood Hits	116
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

PER1_MOUSE
NC score	0.011670 (rank : 1584)	θ value	1.38821 (rank : 1342)
Query Neighborhood Hits	1804	Target Neighborhood Hits	235	Shared Neighborhood Hits	95
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

SREC2_HUMAN
NC score	0.011607 (rank : 1585)	θ value	0.21417 (rank : 1134)
Query Neighborhood Hits	1804	Target Neighborhood Hits	645	Shared Neighborhood Hits	136
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

MKL2_MOUSE
NC score	0.011597 (rank : 1586)	θ value	2.36792 (rank : 1433)
Query Neighborhood Hits	1804	Target Neighborhood Hits	269	Shared Neighborhood Hits	77
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

GP156_HUMAN
NC score	0.011498 (rank : 1587)	θ value	0.125558 (rank : 1069)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

CBL_HUMAN
NC score	0.011486 (rank : 1588)	θ value	0.813845 (rank : 1257)
Query Neighborhood Hits	1804	Target Neighborhood Hits	353	Shared Neighborhood Hits	98
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

UBP10_HUMAN
NC score	0.011295 (rank : 1589)	θ value	0.0148317 (rank : 937)
Query Neighborhood Hits	1804	Target Neighborhood Hits	153	Shared Neighborhood Hits	47
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

IF39_HUMAN
NC score	0.011191 (rank : 1590)	θ value	5.27518 (rank : 1597)
Query Neighborhood Hits	1804	Target Neighborhood Hits	187	Shared Neighborhood Hits	53
SwissProt Accessions	P55884, Q9UMF9	Gene names	EIF3S9
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 p110) (eIF3b) (Prt1 homolog) (hPrt1).

VGLL4_MOUSE
NC score	0.011188 (rank : 1591)	θ value	0.813845 (rank : 1275)
Query Neighborhood Hits	1804	Target Neighborhood Hits	16	Shared Neighborhood Hits	10
SwissProt Accessions	Q80V24	Gene names	Vgll4
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

ANTR1_MOUSE
NC score	0.011075 (rank : 1592)	θ value	1.06291 (rank : 1280)
Query Neighborhood Hits	1804	Target Neighborhood Hits	143	Shared Neighborhood Hits	61
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

CIKS_HUMAN
NC score	0.011069 (rank : 1593)	θ value	1.81305 (rank : 1361)
Query Neighborhood Hits	1804	Target Neighborhood Hits	60	Shared Neighborhood Hits	21
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

DOK1_HUMAN
NC score	0.010933 (rank : 1594)	θ value	0.21417 (rank : 1125)
Query Neighborhood Hits	1804	Target Neighborhood Hits	85	Shared Neighborhood Hits	39
SwissProt Accessions	Q99704, O43204, Q9UHG6	Gene names	DOK1
Domain Architecture
Description	Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62).

PROL4_HUMAN
NC score	0.010928 (rank : 1595)	θ value	3.0926 (rank : 1482)
Query Neighborhood Hits	1804	Target Neighborhood Hits	23	Shared Neighborhood Hits	5
SwissProt Accessions	Q16378, Q8NFB3	Gene names	PRR4, LPRP, PROL4
Domain Architecture	No domain graphic available
Description	Proline-rich protein 4 precursor (Lacrimal proline-rich protein) (Nasopharyngeal carcinoma-associated proline-rich protein 4).

PO6F2_MOUSE
NC score	0.010557 (rank : 1596)	θ value	0.163984 (rank : 1101)
Query Neighborhood Hits	1804	Target Neighborhood Hits	639	Shared Neighborhood Hits	154
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

TTC28_MOUSE
NC score	0.010553 (rank : 1597)	θ value	5.27518 (rank : 1641)
Query Neighborhood Hits	1804	Target Neighborhood Hits	194	Shared Neighborhood Hits	56
SwissProt Accessions	Q80XJ3, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2	Gene names	Ttc28, Kiaa1043
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

NCOA2_MOUSE
NC score	0.010520 (rank : 1598)	θ value	6.88961 (rank : 1688)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

DLG7_HUMAN
NC score	0.010435 (rank : 1599)	θ value	0.47712 (rank : 1196)
Query Neighborhood Hits	1804	Target Neighborhood Hits	53	Shared Neighborhood Hits	14
SwissProt Accessions	Q15398, Q8NG58	Gene names	DLG7, KIAA0008
Domain Architecture
Description	Discs large homolog 7 (Hepatoma up-regulated protein) (HURP).

LMBL3_MOUSE
NC score	0.010408 (rank : 1600)	θ value	8.99809 (rank : 1760)
Query Neighborhood Hits	1804	Target Neighborhood Hits	212	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BLB7, Q641L7, Q6ZPI2, Q8C0G4	Gene names	L3mbtl3
Domain Architecture	No domain graphic available
Description	Lethal(3)malignant brain tumor-like 3 protein (L(3)mbt-like 3 protein).

CBX4_HUMAN
NC score	0.010329 (rank : 1601)	θ value	0.0193708 (rank : 943)
Query Neighborhood Hits	1804	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	O00257, Q96C04	Gene names	CBX4
Domain Architecture
Description	Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (hPc2).

DDEF2_HUMAN
NC score	0.010287 (rank : 1602)	θ value	0.47712 (rank : 1195)
Query Neighborhood Hits	1804	Target Neighborhood Hits	599	Shared Neighborhood Hits	120
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SOS1_MOUSE
NC score	0.010274 (rank : 1603)	θ value	0.62314 (rank : 1249)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	78
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SMCA2_HUMAN
NC score	0.010256 (rank : 1604)	θ value	8.99809 (rank : 1786)
Query Neighborhood Hits	1804	Target Neighborhood Hits	503	Shared Neighborhood Hits	137
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

CO8A1_HUMAN
NC score	0.010251 (rank : 1605)	θ value	0.47712 (rank : 1193)
Query Neighborhood Hits	1804	Target Neighborhood Hits	288	Shared Neighborhood Hits	91
SwissProt Accessions	P27658, Q96D07	Gene names	COL8A1
Domain Architecture
Description	Collagen alpha-1(VIII) chain precursor (Endothelial collagen).

RHG04_HUMAN
NC score	0.010224 (rank : 1606)	θ value	4.03905 (rank : 1555)
Query Neighborhood Hits	1804	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

WTAP_HUMAN
NC score	0.010213 (rank : 1607)	θ value	8.99809 (rank : 1802)
Query Neighborhood Hits	1804	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

DOCK4_HUMAN
NC score	0.010071 (rank : 1608)	θ value	3.0926 (rank : 1465)
Query Neighborhood Hits	1804	Target Neighborhood Hits	237	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

NFAC2_HUMAN
NC score	0.009974 (rank : 1609)	θ value	0.163984 (rank : 1099)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	48
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

NCOA2_HUMAN
NC score	0.009962 (rank : 1610)	θ value	2.36792 (rank : 1435)
Query Neighborhood Hits	1804	Target Neighborhood Hits	281	Shared Neighborhood Hits	109
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

DDEF2_MOUSE
NC score	0.009875 (rank : 1611)	θ value	5.27518 (rank : 1591)
Query Neighborhood Hits	1804	Target Neighborhood Hits	625	Shared Neighborhood Hits	134
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SIN3A_HUMAN
NC score	0.009857 (rank : 1612)	θ value	2.36792 (rank : 1438)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	72
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

MCPH1_MOUSE
NC score	0.009750 (rank : 1613)	θ value	2.36792 (rank : 1432)
Query Neighborhood Hits	1804	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TT79, Q8BNI9, Q8C9I7	Gene names	Mcph1
Domain Architecture
Description	Microcephalin.

PRR6_HUMAN
NC score	0.009596 (rank : 1614)	θ value	3.0926 (rank : 1483)
Query Neighborhood Hits	1804	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z7K6, Q3L8N5, Q8NFH6	Gene names	PRR6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6 (Nuclear protein p30).

K0562_MOUSE
NC score	0.009563 (rank : 1615)	θ value	1.81305 (rank : 1373)
Query Neighborhood Hits	1804	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q80V31, Q6ZQ95	Gene names	Kiaa0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

SYMPK_HUMAN
NC score	0.009514 (rank : 1616)	θ value	6.88961 (rank : 1711)
Query Neighborhood Hits	1804	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

VGLL4_HUMAN
NC score	0.009480 (rank : 1617)	θ value	8.99809 (rank : 1801)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	11
SwissProt Accessions	Q14135, Q7L5V0, Q9BQ78	Gene names	VGLL4, KIAA0121
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

CAC1A_HUMAN
NC score	0.009471 (rank : 1618)	θ value	3.0926 (rank : 1456)
Query Neighborhood Hits	1804	Target Neighborhood Hits	387	Shared Neighborhood Hits	145
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

EST1A_HUMAN
NC score	0.009457 (rank : 1619)	θ value	4.03905 (rank : 1513)
Query Neighborhood Hits	1804	Target Neighborhood Hits	98	Shared Neighborhood Hits	20
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

NOP56_MOUSE
NC score	0.009303 (rank : 1620)	θ value	4.03905 (rank : 1542)
Query Neighborhood Hits	1804	Target Neighborhood Hits	129	Shared Neighborhood Hits	44
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

DACT1_MOUSE
NC score	0.009225 (rank : 1621)	θ value	6.88961 (rank : 1669)
Query Neighborhood Hits	1804	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q8R4A3, Q80VG9, Q8BP49, Q9JK89	Gene names	Dact1, Thyex3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (MDpr1) (Frodo) (Thymus-expressed novel gene 3 protein).

HD_HUMAN
NC score	0.009193 (rank : 1622)	θ value	0.813845 (rank : 1263)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

CBX6_HUMAN
NC score	0.009074 (rank : 1623)	θ value	1.06291 (rank : 1285)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	40
SwissProt Accessions	O95503, Q96EM5	Gene names	CBX6
Domain Architecture
Description	Chromobox protein homolog 6.

REPS2_HUMAN
NC score	0.008929 (rank : 1624)	θ value	4.03905 (rank : 1554)
Query Neighborhood Hits	1804	Target Neighborhood Hits	131	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

COAA1_MOUSE
NC score	0.008804 (rank : 1625)	θ value	4.03905 (rank : 1509)
Query Neighborhood Hits	1804	Target Neighborhood Hits	286	Shared Neighborhood Hits	87
SwissProt Accessions	Q05306	Gene names	Col10a1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

SAPS1_MOUSE
NC score	0.008411 (rank : 1626)	θ value	8.99809 (rank : 1780)
Query Neighborhood Hits	1804	Target Neighborhood Hits	144	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

CABYR_MOUSE
NC score	0.008356 (rank : 1627)	θ value	8.99809 (rank : 1731)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

HAIR_HUMAN
NC score	0.008342 (rank : 1628)	θ value	4.03905 (rank : 1521)
Query Neighborhood Hits	1804	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

DACH1_HUMAN
NC score	0.008161 (rank : 1629)	θ value	6.88961 (rank : 1667)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

ZMYM3_MOUSE
NC score	0.008021 (rank : 1630)	θ value	1.38821 (rank : 1354)
Query Neighborhood Hits	1804	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

NCKX1_HUMAN
NC score	0.008021 (rank : 1631)	θ value	1.81305 (rank : 1377)
Query Neighborhood Hits	1804	Target Neighborhood Hits	223	Shared Neighborhood Hits	61
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

CO9A2_HUMAN
NC score	0.007965 (rank : 1632)	θ value	6.88961 (rank : 1663)
Query Neighborhood Hits	1804	Target Neighborhood Hits	261	Shared Neighborhood Hits	79
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

SI1L2_MOUSE
NC score	0.007939 (rank : 1633)	θ value	8.99809 (rank : 1784)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	50
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

KCNH3_HUMAN
NC score	0.007916 (rank : 1634)	θ value	4.03905 (rank : 1526)
Query Neighborhood Hits	1804	Target Neighborhood Hits	148	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

GGA1_HUMAN
NC score	0.007552 (rank : 1635)	θ value	8.99809 (rank : 1746)
Query Neighborhood Hits	1804	Target Neighborhood Hits	169	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

HUWE1_MOUSE
NC score	0.007460 (rank : 1636)	θ value	2.36792 (rank : 1426)
Query Neighborhood Hits	1804	Target Neighborhood Hits	406	Shared Neighborhood Hits	103
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TIRAP_MOUSE
NC score	0.007428 (rank : 1637)	θ value	0.62314 (rank : 1252)
Query Neighborhood Hits	1804	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JY1, Q91ZW0	Gene names	Tirap, Mal
Domain Architecture
Description	Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (MyD88 adapter-like protein) (Adaptor protein Wyatt).

JPH4_HUMAN
NC score	0.007416 (rank : 1638)	θ value	1.38821 (rank : 1334)
Query Neighborhood Hits	1804	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

ODO2_HUMAN
NC score	0.007407 (rank : 1639)	θ value	5.27518 (rank : 1618)
Query Neighborhood Hits	1804	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

ARI3A_HUMAN
NC score	0.007231 (rank : 1640)	θ value	8.99809 (rank : 1727)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

CCNK_HUMAN
NC score	0.007217 (rank : 1641)	θ value	3.0926 (rank : 1458)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O75909, Q96B63, Q9NNY9	Gene names	CCNK, CPR4
Domain Architecture
Description	Cyclin-K.

TUB_MOUSE
NC score	0.007187 (rank : 1642)	θ value	0.365318 (rank : 1185)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	P50586	Gene names	Tub, Rd5
Domain Architecture
Description	Tubby protein.

TUB_HUMAN
NC score	0.007176 (rank : 1643)	θ value	0.163984 (rank : 1112)
Query Neighborhood Hits	1804	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	P50607, O00293	Gene names	TUB
Domain Architecture
Description	Tubby protein homolog.

JADE2_HUMAN
NC score	0.007158 (rank : 1644)	θ value	3.0926 (rank : 1468)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

TAB3_HUMAN
NC score	0.007063 (rank : 1645)	θ value	6.88961 (rank : 1712)
Query Neighborhood Hits	1804	Target Neighborhood Hits	168	Shared Neighborhood Hits	46
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

SREC2_MOUSE
NC score	0.006856 (rank : 1646)	θ value	0.0148317 (rank : 935)
Query Neighborhood Hits	1804	Target Neighborhood Hits	605	Shared Neighborhood Hits	119
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

PO6F2_HUMAN
NC score	0.006775 (rank : 1647)	θ value	0.0563607 (rank : 1026)
Query Neighborhood Hits	1804	Target Neighborhood Hits	618	Shared Neighborhood Hits	135
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

NUMBL_MOUSE
NC score	0.006744 (rank : 1648)	θ value	6.88961 (rank : 1694)
Query Neighborhood Hits	1804	Target Neighborhood Hits	147	Shared Neighborhood Hits	66
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

MATR3_HUMAN
NC score	0.006670 (rank : 1649)	θ value	3.0926 (rank : 1473)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	63
SwissProt Accessions	P43243, Q9UHW0, Q9UQ27	Gene names	MATR3, KIAA0723
Domain Architecture
Description	Matrin-3.

MYC_HUMAN
NC score	0.006644 (rank : 1650)	θ value	0.47712 (rank : 1203)
Query Neighborhood Hits	1804	Target Neighborhood Hits	146	Shared Neighborhood Hits	29
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

PANK1_HUMAN
NC score	0.006542 (rank : 1651)	θ value	0.125558 (rank : 1075)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TE04, Q7RTX6, Q7Z495, Q8TBQ8	Gene names	PANK1, PANK
Domain Architecture
Description	Pantothenate kinase 1 (EC 2.7.1.33) (Pantothenic acid kinase 1) (hPanK1) (hPanK).

AIRE_MOUSE
NC score	0.006531 (rank : 1652)	θ value	8.99809 (rank : 1725)
Query Neighborhood Hits	1804	Target Neighborhood Hits	196	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

WWTR1_HUMAN
NC score	0.006414 (rank : 1653)	θ value	5.27518 (rank : 1647)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

JPH1_MOUSE
NC score	0.006410 (rank : 1654)	θ value	4.03905 (rank : 1523)
Query Neighborhood Hits	1804	Target Neighborhood Hits	120	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

SYV_HUMAN
NC score	0.006401 (rank : 1655)	θ value	0.279714 (rank : 1158)
Query Neighborhood Hits	1804	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

TF65_HUMAN
NC score	0.006388 (rank : 1656)	θ value	1.06291 (rank : 1309)
Query Neighborhood Hits	1804	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

ARHGG_MOUSE
NC score	0.006308 (rank : 1657)	θ value	0.279714 (rank : 1140)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	25
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

AKTS1_MOUSE
NC score	0.006237 (rank : 1658)	θ value	4.03905 (rank : 1496)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D1F4	Gene names	Akt1s1, Pras
Domain Architecture	No domain graphic available
Description	Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate).

NELF_HUMAN
NC score	0.006125 (rank : 1659)	θ value	1.81305 (rank : 1378)
Query Neighborhood Hits	1804	Target Neighborhood Hits	24	Shared Neighborhood Hits	10
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

JHD3B_MOUSE
NC score	0.006089 (rank : 1660)	θ value	1.38821 (rank : 1333)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	63
SwissProt Accessions	Q91VY5, Q3UR22, Q6ZQ30, Q99K42	Gene names	Jmjd2b, Jhdm3b
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

CHD9_MOUSE
NC score	0.006072 (rank : 1661)	θ value	1.06291 (rank : 1286)
Query Neighborhood Hits	1804	Target Neighborhood Hits	427	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CU005_HUMAN
NC score	0.006055 (rank : 1662)	θ value	2.36792 (rank : 1421)
Query Neighborhood Hits	1804	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y3R5, Q9UEZ3	Gene names	C21orf5, KIAA0933
Domain Architecture
Description	Protein C21orf5.

LRC50_HUMAN
NC score	0.005867 (rank : 1663)	θ value	0.62314 (rank : 1243)
Query Neighborhood Hits	1804	Target Neighborhood Hits	275	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

DNM3A_HUMAN
NC score	0.005853 (rank : 1664)	θ value	1.06291 (rank : 1294)
Query Neighborhood Hits	1804	Target Neighborhood Hits	104	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6K1, Q8WXU9	Gene names	DNMT3A
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37) (Dnmt3a) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA).

MEF2C_HUMAN
NC score	0.005758 (rank : 1665)	θ value	8.99809 (rank : 1764)
Query Neighborhood Hits	1804	Target Neighborhood Hits	90	Shared Neighborhood Hits	40
SwissProt Accessions	Q06413	Gene names	MEF2C
Domain Architecture
Description	Myocyte-specific enhancer factor 2C.

PDXL2_HUMAN
NC score	0.005722 (rank : 1666)	θ value	5.27518 (rank : 1625)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NZ53, Q6UVY4, Q8WUV6	Gene names	PODXL2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

MAGB6_HUMAN
NC score	0.005505 (rank : 1667)	θ value	3.0926 (rank : 1472)
Query Neighborhood Hits	1804	Target Neighborhood Hits	184	Shared Neighborhood Hits	77
SwissProt Accessions	Q8N7X4, Q6GS19, Q9H219	Gene names	MAGEB6
Domain Architecture
Description	Melanoma-associated antigen B6 (MAGE-B6 antigen).

CO6A3_HUMAN
NC score	0.005499 (rank : 1668)	θ value	1.81305 (rank : 1364)
Query Neighborhood Hits	1804	Target Neighborhood Hits	317	Shared Neighborhood Hits	89
SwissProt Accessions	P12111, Q16501	Gene names	COL6A3
Domain Architecture
Description	Collagen alpha-3(VI) chain precursor.

CK035_MOUSE
NC score	0.005368 (rank : 1669)	θ value	3.0926 (rank : 1461)
Query Neighborhood Hits	1804	Target Neighborhood Hits	91	Shared Neighborhood Hits	13
SwissProt Accessions	Q0VET5, Q9CW10	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35 homolog.

AXN1_MOUSE
NC score	0.005324 (rank : 1670)	θ value	1.38821 (rank : 1321)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	O35625	Gene names	Axin1, Axin, Fu
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (Fused protein).

CND1_HUMAN
NC score	0.005310 (rank : 1671)	θ value	1.06291 (rank : 1288)
Query Neighborhood Hits	1804	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

CAC1B_MOUSE
NC score	0.005199 (rank : 1672)	θ value	2.36792 (rank : 1409)
Query Neighborhood Hits	1804	Target Neighborhood Hits	351	Shared Neighborhood Hits	113
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

APBB2_MOUSE
NC score	0.005172 (rank : 1673)	θ value	1.81305 (rank : 1356)
Query Neighborhood Hits	1804	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

KCNH3_MOUSE
NC score	0.005123 (rank : 1674)	θ value	4.03905 (rank : 1527)
Query Neighborhood Hits	1804	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

WFS1_HUMAN
NC score	0.005036 (rank : 1675)	θ value	4.03905 (rank : 1567)
Query Neighborhood Hits	1804	Target Neighborhood Hits	42	Shared Neighborhood Hits	12
SwissProt Accessions	O76024, Q8N6I3, Q9UNW6	Gene names	WFS1
Domain Architecture	No domain graphic available
Description	Wolframin.

DTX2_MOUSE
NC score	0.005009 (rank : 1676)	θ value	0.813845 (rank : 1259)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q8R3P2, Q9CZV3, Q9ER07, Q9ER08	Gene names	Dtx2
Domain Architecture
Description	Protein deltex-2 (Deltex-2) (Deltex2) (mDTX2).

KCNH2_HUMAN
NC score	0.004967 (rank : 1677)	θ value	2.36792 (rank : 1429)
Query Neighborhood Hits	1804	Target Neighborhood Hits	158	Shared Neighborhood Hits	43
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

MIA2_MOUSE
NC score	0.004907 (rank : 1678)	θ value	4.03905 (rank : 1535)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q91ZV0	Gene names	Mia2
Domain Architecture	No domain graphic available
Description	Melanoma inhibitory activity protein 2 precursor.

SACS_HUMAN
NC score	0.004850 (rank : 1679)	θ value	0.62314 (rank : 1247)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

TBX2_HUMAN
NC score	0.004714 (rank : 1680)	θ value	1.81305 (rank : 1398)
Query Neighborhood Hits	1804	Target Neighborhood Hits	195	Shared Neighborhood Hits	81
SwissProt Accessions	Q13207, Q16424, Q7Z647	Gene names	TBX2
Domain Architecture
Description	T-box transcription factor TBX2 (T-box protein 2).

UBXD3_MOUSE
NC score	0.004696 (rank : 1681)	θ value	5.27518 (rank : 1644)
Query Neighborhood Hits	1804	Target Neighborhood Hits	17	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG34, Q3TTR1, Q8BP58, Q8R0B6	Gene names	Ubxd3
Domain Architecture	No domain graphic available
Description	UBX domain-containing protein 3.

CLMN_MOUSE
NC score	0.004646 (rank : 1682)	θ value	1.81305 (rank : 1363)
Query Neighborhood Hits	1804	Target Neighborhood Hits	180	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

MNDA_HUMAN
NC score	0.004633 (rank : 1683)	θ value	8.99809 (rank : 1765)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	P41218	Gene names	MNDA
Domain Architecture
Description	Myeloid cell nuclear differentiation antigen.

NIBA_HUMAN
NC score	0.004373 (rank : 1684)	θ value	4.03905 (rank : 1541)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZQ8, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9	Gene names	C1orf24
Domain Architecture	No domain graphic available
Description	Niban protein.

AXN1_HUMAN
NC score	0.004278 (rank : 1685)	θ value	6.88961 (rank : 1653)
Query Neighborhood Hits	1804	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	O15169, Q4TT26, Q4TT27, Q86YA7, Q8WVW6, Q96S28	Gene names	AXIN1, AXIN
Domain Architecture
Description	Axin-1 (Axis inhibition protein 1) (hAxin).

KCT2_MOUSE
NC score	0.004039 (rank : 1686)	θ value	8.99809 (rank : 1757)
Query Neighborhood Hits	1804	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K201, Q5SVC5, Q922L7, Q9CVN1	Gene names	Kct2
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

SEM6C_MOUSE
NC score	0.003940 (rank : 1687)	θ value	0.47712 (rank : 1212)
Query Neighborhood Hits	1804	Target Neighborhood Hits	352	Shared Neighborhood Hits	136
SwissProt Accessions	Q9WTM3	Gene names	Sema6c, Semay
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

PAIRB_MOUSE
NC score	0.003936 (rank : 1688)	θ value	5.27518 (rank : 1619)
Query Neighborhood Hits	1804	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CY58, Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6	Gene names	Serbp1, Pairbp1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

UBP2_HUMAN
NC score	0.003861 (rank : 1689)	θ value	5.27518 (rank : 1642)
Query Neighborhood Hits	1804	Target Neighborhood Hits	84	Shared Neighborhood Hits	15
SwissProt Accessions	O75604, Q96MB9, Q9BQ21	Gene names	USP2, UBP41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

SSH1_MOUSE
NC score	0.003823 (rank : 1690)	θ value	0.0736092 (rank : 1046)
Query Neighborhood Hits	1804	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q76I79, Q3TDG3, Q69ZM4, Q811E5	Gene names	Ssh1, Kiaa1298, Ssh1l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (mSSH-1L).

PA2G3_HUMAN
NC score	0.003767 (rank : 1691)	θ value	6.88961 (rank : 1695)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZ20, O95768	Gene names	PLA2G3
Domain Architecture
Description	Group 3 secretory phospholipase A2 precursor (EC 3.1.1.4) (Group III secretory phospholipase A2) (Phosphatidylcholine 2-acylhydrolase GIII) (GIII sPLA2).

TOX_HUMAN
NC score	0.003755 (rank : 1692)	θ value	1.06291 (rank : 1311)
Query Neighborhood Hits	1804	Target Neighborhood Hits	106	Shared Neighborhood Hits	31
SwissProt Accessions	O94900, Q96AV5	Gene names	TOX, KIAA0808
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

HTRA4_HUMAN
NC score	0.003725 (rank : 1693)	θ value	6.88961 (rank : 1680)
Query Neighborhood Hits	1804	Target Neighborhood Hits	119	Shared Neighborhood Hits	40
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

CN152_HUMAN
NC score	0.003725 (rank : 1694)	θ value	6.88961 (rank : 1662)
Query Neighborhood Hits	1804	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N9Y4, Q96GY1	Gene names	C14orf152
Domain Architecture	No domain graphic available
Description	Protein C14orf152.

KCNH2_MOUSE
NC score	0.003584 (rank : 1695)	θ value	6.88961 (rank : 1684)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	49
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

TTLL7_HUMAN
NC score	0.003579 (rank : 1696)	θ value	3.0926 (rank : 1492)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

GTR10_HUMAN
NC score	0.003579 (rank : 1697)	θ value	0.62314 (rank : 1231)
Query Neighborhood Hits	1804	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O95528, Q9H4I6	Gene names	SLC2A10, GLUT10
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 10 (Glucose transporter type 10).

JPH1_HUMAN
NC score	0.003474 (rank : 1698)	θ value	6.88961 (rank : 1682)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

ITCH_HUMAN
NC score	0.003440 (rank : 1699)	θ value	1.81305 (rank : 1372)
Query Neighborhood Hits	1804	Target Neighborhood Hits	162	Shared Neighborhood Hits	36
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

G3BP2_MOUSE
NC score	0.003423 (rank : 1700)	θ value	0.813845 (rank : 1261)
Query Neighborhood Hits	1804	Target Neighborhood Hits	258	Shared Neighborhood Hits	52
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

ABCF1_MOUSE
NC score	0.003326 (rank : 1701)	θ value	8.99809 (rank : 1721)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	64
SwissProt Accessions	Q6P542, Q6NV71	Gene names	Abcf1
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family F member 1.

RAI2_HUMAN
NC score	0.003277 (rank : 1702)	θ value	6.88961 (rank : 1702)
Query Neighborhood Hits	1804	Target Neighborhood Hits	53	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5P3, Q8N6X7	Gene names	RAI2
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 2.

XYLT2_MOUSE
NC score	0.003250 (rank : 1703)	θ value	1.81305 (rank : 1404)
Query Neighborhood Hits	1804	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	Q9EPL0, Q5SUY1, Q8K060	Gene names	Xylt2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (Peptide O- xylosyltransferase 2).

AP3B2_MOUSE
NC score	0.003209 (rank : 1704)	θ value	2.36792 (rank : 1407)
Query Neighborhood Hits	1804	Target Neighborhood Hits	246	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JME5, Q6QR53, Q8R1E5	Gene names	Ap3b2
Domain Architecture	No domain graphic available
Description	AP-3 complex subunit beta-2 (Adapter-related protein complex 3 beta-2 subunit) (Beta3B-adaptin) (Adaptor protein complex AP-3 beta-2 subunit) (Clathrin assembly protein complex 3 beta-2 large chain).

UBP36_HUMAN
NC score	0.003196 (rank : 1705)	θ value	8.99809 (rank : 1799)
Query Neighborhood Hits	1804	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

CO6A1_HUMAN
NC score	0.003192 (rank : 1706)	θ value	5.27518 (rank : 1585)
Query Neighborhood Hits	1804	Target Neighborhood Hits	264	Shared Neighborhood Hits	57
SwissProt Accessions	P12109, O00117, O00118, Q14040, Q14041, Q16258	Gene names	COL6A1
Domain Architecture
Description	Collagen alpha-1(VI) chain precursor.

CBLB_MOUSE
NC score	0.003162 (rank : 1707)	θ value	1.81305 (rank : 1359)
Query Neighborhood Hits	1804	Target Neighborhood Hits	277	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

SSH3_HUMAN
NC score	0.002990 (rank : 1708)	θ value	0.0961366 (rank : 1061)
Query Neighborhood Hits	1804	Target Neighborhood Hits	75	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TE77, Q6PK42, Q76I75, Q8N9L8, Q8WYL0, Q9NV45, Q9NWZ7	Gene names	SSH3, SSH3L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L).

XYLT2_HUMAN
NC score	0.002980 (rank : 1709)	θ value	3.0926 (rank : 1493)
Query Neighborhood Hits	1804	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H1B5, Q6UY41, Q86V00	Gene names	XYLT2, XT2
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 2 (EC 2.4.2.26) (Xylosyltransferase II) (xylT-II) (XT-II) (Peptide O-xylosyltransferase 1).

FOSB_MOUSE
NC score	0.002975 (rank : 1710)	θ value	6.88961 (rank : 1674)
Query Neighborhood Hits	1804	Target Neighborhood Hits	137	Shared Neighborhood Hits	23
SwissProt Accessions	P13346	Gene names	Fosb
Domain Architecture	No domain graphic available
Description	Protein fosB.

SSH2_HUMAN
NC score	0.002969 (rank : 1711)	θ value	2.36792 (rank : 1440)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	33
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

UBAP1_MOUSE
NC score	0.002922 (rank : 1712)	θ value	4.03905 (rank : 1564)
Query Neighborhood Hits	1804	Target Neighborhood Hits	32	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BH48, Q8BQ80, Q8BSW6, Q9D749, Q9ERV5	Gene names	Ubap1
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 1 (UBAP) (Ubiquitin-associated protein NAG20).

UBQL3_MOUSE
NC score	0.002781 (rank : 1713)	θ value	6.88961 (rank : 1715)
Query Neighborhood Hits	1804	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C5U9	Gene names	Ubqln3
Domain Architecture
Description	Ubiquilin-3.

SRTD1_HUMAN
NC score	0.002755 (rank : 1714)	θ value	5.27518 (rank : 1635)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UHV2, Q9BUE7	Gene names	SERTAD1, SEI1
Domain Architecture
Description	SERTA domain-containing protein 1 (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1) (CDK4-binding protein p34SEI1) (SEI-1).

JHD3B_HUMAN
NC score	0.002753 (rank : 1715)	θ value	5.27518 (rank : 1602)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	40
SwissProt Accessions	O94953, O75274, Q6P3R5, Q9P1V1, Q9UF40	Gene names	JMJD2B, JHDM3B, KIAA0876
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3B (EC 1.14.11.-) (Jumonji domain-containing protein 2B).

INT1_HUMAN
NC score	0.002725 (rank : 1716)	θ value	5.27518 (rank : 1599)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N201, Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8, Q9Y3W8	Gene names	INTS1, KIAA1440
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 1 (Int1).

POLK_HUMAN
NC score	0.002642 (rank : 1717)	θ value	6.88961 (rank : 1699)
Query Neighborhood Hits	1804	Target Neighborhood Hits	64	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UBT6, Q86VJ8, Q8IZY0, Q8IZY1, Q8NB30, Q96L01, Q96Q86, Q96Q87, Q9UHC5	Gene names	POLK, DINB1
Domain Architecture	No domain graphic available
Description	DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP).

DCBD1_HUMAN
NC score	0.002422 (rank : 1718)	θ value	4.03905 (rank : 1511)
Query Neighborhood Hits	1804	Target Neighborhood Hits	110	Shared Neighborhood Hits	20
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

SCEL_MOUSE
NC score	0.002401 (rank : 1719)	θ value	8.99809 (rank : 1781)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	23
SwissProt Accessions	Q9EQG3, Q9CTT9	Gene names	Scel
Domain Architecture
Description	Sciellin.

G3BP2_HUMAN
NC score	0.002199 (rank : 1720)	θ value	4.03905 (rank : 1519)
Query Neighborhood Hits	1804	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

WRIP1_HUMAN
NC score	0.002183 (rank : 1721)	θ value	5.27518 (rank : 1646)
Query Neighborhood Hits	1804	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

OPHN1_HUMAN
NC score	0.002172 (rank : 1722)	θ value	1.38821 (rank : 1339)
Query Neighborhood Hits	1804	Target Neighborhood Hits	161	Shared Neighborhood Hits	38
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

NOTC2_HUMAN
NC score	0.002082 (rank : 1723)	θ value	1.81305 (rank : 1381)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1113	Shared Neighborhood Hits	199
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

CAC1B_HUMAN
NC score	0.002026 (rank : 1724)	θ value	1.38821 (rank : 1323)
Query Neighborhood Hits	1804	Target Neighborhood Hits	257	Shared Neighborhood Hits	68
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

PR285_HUMAN
NC score	0.002017 (rank : 1725)	θ value	4.03905 (rank : 1550)
Query Neighborhood Hits	1804	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

FOXM1_HUMAN
NC score	0.002014 (rank : 1726)	θ value	4.03905 (rank : 1517)
Query Neighborhood Hits	1804	Target Neighborhood Hits	167	Shared Neighborhood Hits	53
SwissProt Accessions	Q08050, O43258, O43259, O43260, Q4ZGG7, Q9BRL2	Gene names	FOXM1, FKHL16, HFH11, MPP2, WIN
Domain Architecture
Description	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11) (HFH-11) (Winged helix factor from INS-1 cells) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident).

SMAD4_HUMAN
NC score	0.001939 (rank : 1727)	θ value	1.06291 (rank : 1305)
Query Neighborhood Hits	1804	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

IRX5_HUMAN
NC score	0.001936 (rank : 1728)	θ value	5.27518 (rank : 1600)
Query Neighborhood Hits	1804	Target Neighborhood Hits	362	Shared Neighborhood Hits	79
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

MKRN3_HUMAN
NC score	0.001762 (rank : 1729)	θ value	1.06291 (rank : 1298)
Query Neighborhood Hits	1804	Target Neighborhood Hits	165	Shared Neighborhood Hits	28
SwissProt Accessions	Q13064	Gene names	MKRN3, RNF63, ZNF127
Domain Architecture
Description	Makorin-3 (Zinc finger protein 127) (RING finger protein 63).

EGLN1_HUMAN
NC score	0.001744 (rank : 1730)	θ value	6.88961 (rank : 1672)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZT9, Q8N3M8, Q9BZS8, Q9BZT0	Gene names	EGLN1, C1orf12
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20).

ZF106_HUMAN
NC score	0.001718 (rank : 1731)	θ value	5.27518 (rank : 1648)
Query Neighborhood Hits	1804	Target Neighborhood Hits	470	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H2Y7, Q6NSD9, Q6PEK1, Q86T43, Q86T45, Q86T50, Q86T58, Q86TA9, Q96M37, Q9H7B8	Gene names	ZFP106, ZNF474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 homolog (Zfp-106) (Zinc finger protein 474).

SIX5_HUMAN
NC score	0.001693 (rank : 1732)	θ value	0.813845 (rank : 1270)
Query Neighborhood Hits	1804	Target Neighborhood Hits	386	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N196	Gene names	SIX5, DMAHP
Domain Architecture	No domain graphic available
Description	Homeobox protein SIX5 (DM locus-associated homeodomain protein).

RIP_MOUSE
NC score	0.001676 (rank : 1733)	θ value	8.99809 (rank : 1777)
Query Neighborhood Hits	1804	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWY9	Gene names	Rpain, Rip
Domain Architecture	No domain graphic available
Description	RPA-interacting protein.

K0513_MOUSE
NC score	0.001675 (rank : 1734)	θ value	8.99809 (rank : 1754)
Query Neighborhood Hits	1804	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0A7, Q80TY8, Q8BQV3, Q8C8N9, Q8CCN0	Gene names	Kiaa0513
Domain Architecture	No domain graphic available
Description	Protein KIAA0513.

PML_MOUSE
NC score	0.001647 (rank : 1735)	θ value	1.81305 (rank : 1388)
Query Neighborhood Hits	1804	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	Q60953	Gene names	Pml
Domain Architecture	No domain graphic available
Description	Probable transcription factor PML.

CN130_MOUSE
NC score	0.001545 (rank : 1736)	θ value	6.88961 (rank : 1661)
Query Neighborhood Hits	1804	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BU04, Q80UT9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf130 homolog.

RN169_HUMAN
NC score	0.001533 (rank : 1737)	θ value	6.88961 (rank : 1704)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RGL2_MOUSE
NC score	0.001351 (rank : 1738)	θ value	5.27518 (rank : 1628)
Query Neighborhood Hits	1804	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

B3A3_HUMAN
NC score	0.001339 (rank : 1739)	θ value	4.03905 (rank : 1498)
Query Neighborhood Hits	1804	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

TOX_MOUSE
NC score	0.001226 (rank : 1740)	θ value	8.99809 (rank : 1795)
Query Neighborhood Hits	1804	Target Neighborhood Hits	95	Shared Neighborhood Hits	24
SwissProt Accessions	Q66JW3, Q8BKH9, Q8BYQ5, Q8R4H0	Gene names	Tox
Domain Architecture	No domain graphic available
Description	Thymus high mobility group box protein TOX.

TAI12_HUMAN
NC score	0.001221 (rank : 1741)	θ value	2.36792 (rank : 1441)
Query Neighborhood Hits	1804	Target Neighborhood Hits	26	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

UBP2_MOUSE
NC score	0.001048 (rank : 1742)	θ value	5.27518 (rank : 1643)
Query Neighborhood Hits	1804	Target Neighborhood Hits	86	Shared Neighborhood Hits	15
SwissProt Accessions	O88623, Q6X4T9, Q6X4U1, Q8VD74, Q9JJ87	Gene names	Usp2, Ubp41
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.1.2.15) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2) (Deubiquitinating enzyme 2) (41 kDa ubiquitin-specific protease).

RBM22_HUMAN
NC score	0.000947 (rank : 1743)	θ value	4.03905 (rank : 1552)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NW64, O95607	Gene names	RBM22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

RBM22_MOUSE
NC score	0.000947 (rank : 1744)	θ value	4.03905 (rank : 1553)
Query Neighborhood Hits	1804	Target Neighborhood Hits	189	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BHS3, Q3TJB0, Q9CXA0	Gene names	Rbm22
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22).

CUL4B_HUMAN
NC score	0.000768 (rank : 1745)	θ value	2.36792 (rank : 1422)
Query Neighborhood Hits	1804	Target Neighborhood Hits	80	Shared Neighborhood Hits	10
SwissProt Accessions	Q13620, Q6PIE4, Q6UP07, Q7Z673, Q9BY37, Q9UEB7, Q9UED7	Gene names	CUL4B, KIAA0695
Domain Architecture
Description	Cullin-4B (CUL-4B).

KCNK4_MOUSE
NC score	0.000752 (rank : 1746)	θ value	8.99809 (rank : 1755)
Query Neighborhood Hits	1804	Target Neighborhood Hits	118	Shared Neighborhood Hits	40
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

JHD1B_MOUSE
NC score	0.000751 (rank : 1747)	θ value	6.88961 (rank : 1681)
Query Neighborhood Hits	1804	Target Neighborhood Hits	214	Shared Neighborhood Hits	47
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

TBC10_HUMAN
NC score	0.000707 (rank : 1748)	θ value	3.0926 (rank : 1488)
Query Neighborhood Hits	1804	Target Neighborhood Hits	64	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXI6, O76053, Q543A2	Gene names	TBC1D10A, EPI64, TBC1D10
Domain Architecture
Description	TBC1 domain family member 10A (EBP50-PDX interactor of 64 kDa) (EPI64 protein).

DDX21_MOUSE
NC score	0.000675 (rank : 1749)	θ value	0.0431538 (rank : 998)
Query Neighborhood Hits	1804	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

CC040_MOUSE
NC score	0.000527 (rank : 1750)	θ value	8.99809 (rank : 1732)
Query Neighborhood Hits	1804	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWU3, Q99KY5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf40 homolog precursor.

CSPG3_HUMAN
NC score	0.000195 (rank : 1751)	θ value	0.279714 (rank : 1143)
Query Neighborhood Hits	1804	Target Neighborhood Hits	676	Shared Neighborhood Hits	130
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CLCN1_MOUSE
NC score	0.000153 (rank : 1752)	θ value	2.36792 (rank : 1413)
Query Neighborhood Hits	1804	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

KI13A_MOUSE
NC score	0.000081 (rank : 1753)	θ value	4.03905 (rank : 1530)
Query Neighborhood Hits	1804	Target Neighborhood Hits	395	Shared Neighborhood Hits	63
SwissProt Accessions	Q9EQW7, O35062	Gene names	Kif13a
Domain Architecture
Description	Kinesin-like protein KIF13A.

PGCB_HUMAN
NC score	0.000074 (rank : 1754)	θ value	0.0736092 (rank : 1041)
Query Neighborhood Hits	1804	Target Neighborhood Hits	478	Shared Neighborhood Hits	79
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

FXR2_HUMAN
NC score	0.000051 (rank : 1755)	θ value	8.99809 (rank : 1745)
Query Neighborhood Hits	1804	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P51116, Q8WUM2	Gene names	FXR2
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 2.

TOB1_MOUSE
NC score	-0.000002 (rank : 1756)	θ value	5.27518 (rank : 1639)
Query Neighborhood Hits	1804	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q61471	Gene names	Tob1, Tob, Trob
Domain Architecture
Description	Tob1 protein (Transducer of erbB-2 1).

JHD1B_HUMAN
NC score	-0.000023 (rank : 1757)	θ value	5.27518 (rank : 1601)
Query Neighborhood Hits	1804	Target Neighborhood Hits	178	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NHM5, Q8NCI2, Q96HC7, Q96SL0, Q96T03, Q9NS96, Q9UF75	Gene names	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (Protein JEMMA) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (CXXC-type zinc finger protein 2) (Protein-containing CXXC domain 2).

OPHN1_MOUSE
NC score	-0.000200 (rank : 1758)	θ value	2.36792 (rank : 1436)
Query Neighborhood Hits	1804	Target Neighborhood Hits	174	Shared Neighborhood Hits	32
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

PEX5R_HUMAN
NC score	-0.000252 (rank : 1759)	θ value	4.03905 (rank : 1548)
Query Neighborhood Hits	1804	Target Neighborhood Hits	102	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IYB4, Q9NQD1, Q9P2U3, Q9P2U4	Gene names	PEX5L, PEX5R, PXR2
Domain Architecture
Description	PEX5-related protein (Peroxin-5-related protein) (Pex5Rp) (PEX5-like protein) (PEX2-related protein).

TBX21_MOUSE
NC score	-0.000258 (rank : 1760)	θ value	2.36792 (rank : 1442)
Query Neighborhood Hits	1804	Target Neighborhood Hits	116	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

KCNK4_HUMAN
NC score	-0.000287 (rank : 1761)	θ value	4.03905 (rank : 1528)
Query Neighborhood Hits	1804	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

CRCM1_MOUSE
NC score	-0.000323 (rank : 1762)	θ value	6.88961 (rank : 1665)
Query Neighborhood Hits	1804	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWG9, Q8BUD4, Q8R586	Gene names	Tmem142a, Cracm1, Orai1
Domain Architecture	No domain graphic available
Description	Calcium release-activated calcium channel protein 1 (Transmembrane protein 142A) (Protein orai-1).

TREF1_MOUSE
NC score	-0.000444 (rank : 1763)	θ value	8.99809 (rank : 1796)
Query Neighborhood Hits	1804	Target Neighborhood Hits	682	Shared Neighborhood Hits	100
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

DGKZ_MOUSE
NC score	-0.000499 (rank : 1764)	θ value	2.36792 (rank : 1423)
Query Neighborhood Hits	1804	Target Neighborhood Hits	542	Shared Neighborhood Hits	42
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

MYC_MOUSE
NC score	-0.000510 (rank : 1765)	θ value	8.99809 (rank : 1769)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

FOXC2_HUMAN
NC score	-0.000521 (rank : 1766)	θ value	4.03905 (rank : 1516)
Query Neighborhood Hits	1804	Target Neighborhood Hits	236	Shared Neighborhood Hits	82
SwissProt Accessions	Q99958	Gene names	FOXC2, FKHL14, MFH1
Domain Architecture
Description	Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14).

BAI1_HUMAN
NC score	-0.000533 (rank : 1767)	θ value	0.125558 (rank : 1066)
Query Neighborhood Hits	1804	Target Neighborhood Hits	375	Shared Neighborhood Hits	83
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

RC3H1_MOUSE
NC score	-0.000594 (rank : 1768)	θ value	3.0926 (rank : 1486)
Query Neighborhood Hits	1804	Target Neighborhood Hits	244	Shared Neighborhood Hits	35
SwissProt Accessions	Q4VGL6, Q69Z31	Gene names	Rc3h1, Gm551, Kiaa2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1) (Sanroque protein).

WDR33_HUMAN
NC score	-0.000751 (rank : 1769)	θ value	6.88961 (rank : 1716)
Query Neighborhood Hits	1804	Target Neighborhood Hits	638	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

KCNN1_HUMAN
NC score	-0.000827 (rank : 1770)	θ value	8.99809 (rank : 1756)
Query Neighborhood Hits	1804	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q92952	Gene names	KCNN1, SK
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 1 (SK1).

MA1C1_HUMAN
NC score	-0.000854 (rank : 1771)	θ value	8.99809 (rank : 1762)
Query Neighborhood Hits	1804	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR34, Q9Y545	Gene names	MAN1C1, MAN1A3, MAN1C
Domain Architecture
Description	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).

KCTD2_HUMAN
NC score	-0.000924 (rank : 1772)	θ value	4.03905 (rank : 1529)
Query Neighborhood Hits	1804	Target Neighborhood Hits	69	Shared Neighborhood Hits	5
SwissProt Accessions	Q14681	Gene names	KCTD2, KIAA0176
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein KCTD2.

RHG06_HUMAN
NC score	-0.000940 (rank : 1773)	θ value	6.88961 (rank : 1703)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	29
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

PP2CG_HUMAN
NC score	-0.001045 (rank : 1774)	θ value	6.88961 (rank : 1700)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	25
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

NPAS2_MOUSE
NC score	-0.001144 (rank : 1775)	θ value	6.88961 (rank : 1692)
Query Neighborhood Hits	1804	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

B3A2_HUMAN
NC score	-0.001179 (rank : 1776)	θ value	6.88961 (rank : 1654)
Query Neighborhood Hits	1804	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	P04920, Q45EY5, Q969L3	Gene names	SLC4A2, AE2, EPB3L1, HKB3, MPB3L
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (BND3L).

FOXD2_MOUSE
NC score	-0.001203 (rank : 1777)	θ value	0.0961366 (rank : 1053)
Query Neighborhood Hits	1804	Target Neighborhood Hits	130	Shared Neighborhood Hits	34
SwissProt Accessions	O35392	Gene names	Foxd2, Mf2
Domain Architecture
Description	Forkhead box protein D2 (Mesoderm/mesenchyme forkhead 2) (MF-2).

GP153_HUMAN
NC score	-0.001390 (rank : 1778)	θ value	0.62314 (rank : 1230)
Query Neighborhood Hits	1804	Target Neighborhood Hits	332	Shared Neighborhood Hits	37
SwissProt Accessions	Q6NV75, Q5TGR5, Q6AHW8, Q86SP8	Gene names	GPR153, PGR1
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1).

FOXM1_MOUSE
NC score	-0.001391 (rank : 1779)	θ value	8.99809 (rank : 1744)
Query Neighborhood Hits	1804	Target Neighborhood Hits	134	Shared Neighborhood Hits	37
SwissProt Accessions	O08696	Gene names	Foxm1, Fkh16
Domain Architecture
Description	Forkhead box protein M1 (Forkhead homolog 16) (Winged-helix transcription factor Trident).

CAF1B_MOUSE
NC score	-0.001461 (rank : 1780)	θ value	0.0736092 (rank : 1030)
Query Neighborhood Hits	1804	Target Neighborhood Hits	385	Shared Neighborhood Hits	71
SwissProt Accessions	Q9D0N7	Gene names	Chaf1b
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60).

FOXD2_HUMAN
NC score	-0.001490 (rank : 1781)	θ value	0.365318 (rank : 1171)
Query Neighborhood Hits	1804	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

CSPG3_MOUSE
NC score	-0.001497 (rank : 1782)	θ value	0.0113563 (rank : 914)
Query Neighborhood Hits	1804	Target Neighborhood Hits	657	Shared Neighborhood Hits	107
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CCG8_HUMAN
NC score	-0.001537 (rank : 1783)	θ value	4.03905 (rank : 1501)
Query Neighborhood Hits	1804	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WXS5, Q9BXT0, Q9BY23	Gene names	CACNG8, CACNG6
Domain Architecture
Description	Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage- gated calcium channel gamma-8 subunit).

TNR3_MOUSE
NC score	-0.001777 (rank : 1784)	θ value	0.813845 (rank : 1273)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	8
SwissProt Accessions	P50284	Gene names	Ltbr, Tnfcr, Tnfrsf3
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 3 precursor (Lymphotoxin-beta receptor).

ADA29_HUMAN
NC score	-0.001806 (rank : 1785)	θ value	0.47712 (rank : 1187)
Query Neighborhood Hits	1804	Target Neighborhood Hits	247	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ATOH1_HUMAN
NC score	-0.002086 (rank : 1786)	θ value	1.38821 (rank : 1320)
Query Neighborhood Hits	1804	Target Neighborhood Hits	97	Shared Neighborhood Hits	9
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

TMG4_MOUSE
NC score	-0.002175 (rank : 1787)	θ value	8.99809 (rank : 1792)
Query Neighborhood Hits	1804	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGN6, Q8BM25	Gene names	Prrg4, Tmg4
Domain Architecture
Description	Transmembrane gamma-carboxyglutamic acid protein 4 precursor (Proline- rich Gla protein 4) (Proline-rich gamma-carboxyglutamic acid protein 4).

UBP21_MOUSE
NC score	-0.002184 (rank : 1788)	θ value	1.81305 (rank : 1400)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QZL6, Q9D0R1	Gene names	Usp21, Usp23
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.1.2.15) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21) (Deubiquitinating enzyme 21).

CSPG4_HUMAN
NC score	-0.002217 (rank : 1789)	θ value	6.88961 (rank : 1666)
Query Neighborhood Hits	1804	Target Neighborhood Hits	112	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

SPAST_MOUSE
NC score	-0.002236 (rank : 1790)	θ value	1.81305 (rank : 1396)
Query Neighborhood Hits	1804	Target Neighborhood Hits	138	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

SIM2_HUMAN
NC score	-0.002313 (rank : 1791)	θ value	6.88961 (rank : 1710)
Query Neighborhood Hits	1804	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

CAC1S_HUMAN
NC score	-0.002352 (rank : 1792)	θ value	5.27518 (rank : 1581)
Query Neighborhood Hits	1804	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

VAT1_MOUSE
NC score	-0.002358 (rank : 1793)	θ value	8.99809 (rank : 1800)
Query Neighborhood Hits	1804	Target Neighborhood Hits	41	Shared Neighborhood Hits	8
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

FOXJ1_MOUSE
NC score	-0.002394 (rank : 1794)	θ value	6.88961 (rank : 1675)
Query Neighborhood Hits	1804	Target Neighborhood Hits	209	Shared Neighborhood Hits	70
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

TRIM8_MOUSE
NC score	-0.002412 (rank : 1795)	θ value	8.99809 (rank : 1798)
Query Neighborhood Hits	1804	Target Neighborhood Hits	674	Shared Neighborhood Hits	88
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

NPAS3_HUMAN
NC score	-0.002488 (rank : 1796)	θ value	4.03905 (rank : 1543)
Query Neighborhood Hits	1804	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

TRPM7_MOUSE
NC score	-0.002522 (rank : 1797)	θ value	2.36792 (rank : 1445)
Query Neighborhood Hits	1804	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

FOG1_MOUSE
NC score	-0.002544 (rank : 1798)	θ value	0.62314 (rank : 1228)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1237	Shared Neighborhood Hits	297
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

EMAL4_HUMAN
NC score	-0.003003 (rank : 1799)	θ value	0.813845 (rank : 1260)
Query Neighborhood Hits	1804	Target Neighborhood Hits	306	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HC35	Gene names	EML4, C2orf2, EMAPL4
Domain Architecture
Description	Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120).

CD45_HUMAN
NC score	-0.003102 (rank : 1800)	θ value	6.88961 (rank : 1659)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	53
SwissProt Accessions	P08575, Q16614, Q9H0Y6	Gene names	PTPRC, CD45
Domain Architecture
Description	Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (CD45 antigen) (T200).

TBX18_MOUSE
NC score	-0.003103 (rank : 1801)	θ value	5.27518 (rank : 1637)
Query Neighborhood Hits	1804	Target Neighborhood Hits	58	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

RNF12_MOUSE
NC score	-0.003144 (rank : 1802)	θ value	8.99809 (rank : 1778)
Query Neighborhood Hits	1804	Target Neighborhood Hits	159	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTV7	Gene names	Rnf12, Rlim
Domain Architecture
Description	RING finger protein 12 (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM).

BAI1_MOUSE
NC score	-0.003329 (rank : 1803)	θ value	1.06291 (rank : 1281)
Query Neighborhood Hits	1804	Target Neighborhood Hits	340	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

DCBD1_MOUSE
NC score	-0.003483 (rank : 1804)	θ value	8.99809 (rank : 1740)
Query Neighborhood Hits	1804	Target Neighborhood Hits	89	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D4J3, Q8R327, Q9D696	Gene names	Dcbld1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

FOXL1_MOUSE
NC score	-0.003662 (rank : 1805)	θ value	1.81305 (rank : 1368)
Query Neighborhood Hits	1804	Target Neighborhood Hits	152	Shared Neighborhood Hits	36
SwissProt Accessions	Q64731	Gene names	Foxl1, Fkh6, Fkhl11
Domain Architecture
Description	Forkhead box protein L1 (Forkhead-related protein FKHL11) (Transcription factor FKH-6).

HNF3A_MOUSE
NC score	-0.003686 (rank : 1806)	θ value	4.03905 (rank : 1522)
Query Neighborhood Hits	1804	Target Neighborhood Hits	140	Shared Neighborhood Hits	34
SwissProt Accessions	P35582, Q61108	Gene names	Foxa1, Hnf3a, Tcf-3a, Tcf3a
Domain Architecture
Description	Hepatocyte nuclear factor 3-alpha (HNF-3A) (Forkhead box protein A1).

SCAP_HUMAN
NC score	-0.003694 (rank : 1807)	θ value	5.27518 (rank : 1631)
Query Neighborhood Hits	1804	Target Neighborhood Hits	368	Shared Neighborhood Hits	79
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

CAH9_HUMAN
NC score	-0.003828 (rank : 1808)	θ value	5.27518 (rank : 1582)
Query Neighborhood Hits	1804	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	Q16790	Gene names	CA9, G250, MN
Domain Architecture
Description	Carbonic anhydrase 9 precursor (EC 4.2.1.1) (Carbonic anhydrase IX) (Carbonate dehydratase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC- associated antigen G250) (pMW1).

KCNA5_HUMAN
NC score	-0.003961 (rank : 1809)	θ value	0.279714 (rank : 1152)
Query Neighborhood Hits	1804	Target Neighborhood Hits	124	Shared Neighborhood Hits	15
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

CSPG2_MOUSE
NC score	-0.004004 (rank : 1810)	θ value	5.27518 (rank : 1588)
Query Neighborhood Hits	1804	Target Neighborhood Hits	711	Shared Neighborhood Hits	103
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

E41LB_HUMAN
NC score	-0.004169 (rank : 1811)	θ value	8.99809 (rank : 1741)
Query Neighborhood Hits	1804	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

ATBF1_MOUSE
NC score	-0.004450 (rank : 1812)	θ value	2.36792 (rank : 1408)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1841	Shared Neighborhood Hits	295
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATS19_HUMAN
NC score	-0.004513 (rank : 1813)	θ value	0.365318 (rank : 1162)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ADA19_MOUSE
NC score	-0.004662 (rank : 1814)	θ value	0.47712 (rank : 1186)
Query Neighborhood Hits	1804	Target Neighborhood Hits	315	Shared Neighborhood Hits	50
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

BSPRY_MOUSE
NC score	-0.005161 (rank : 1815)	θ value	6.88961 (rank : 1655)
Query Neighborhood Hits	1804	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

RXRB_MOUSE
NC score	-0.005421 (rank : 1816)	θ value	0.47712 (rank : 1207)
Query Neighborhood Hits	1804	Target Neighborhood Hits	230	Shared Neighborhood Hits	53
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

LIRB5_HUMAN
NC score	-0.005440 (rank : 1817)	θ value	8.99809 (rank : 1759)
Query Neighborhood Hits	1804	Target Neighborhood Hits	100	Shared Neighborhood Hits	8
SwissProt Accessions	O75023, Q8N760	Gene names	LILRB5, LIR8
Domain Architecture
Description	Leukocyte immunoglobulin-like receptor subfamily B member 5 precursor (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD85c antigen).

LTBP2_MOUSE
NC score	-0.005867 (rank : 1818)	θ value	5.27518 (rank : 1608)
Query Neighborhood Hits	1804	Target Neighborhood Hits	617	Shared Neighborhood Hits	105
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

BAI2_MOUSE
NC score	-0.005888 (rank : 1819)	θ value	5.27518 (rank : 1578)
Query Neighborhood Hits	1804	Target Neighborhood Hits	323	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

HXA3_MOUSE
NC score	-0.005977 (rank : 1820)	θ value	8.99809 (rank : 1752)
Query Neighborhood Hits	1804	Target Neighborhood Hits	558	Shared Neighborhood Hits	125
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

ADAM9_HUMAN
NC score	-0.006011 (rank : 1821)	θ value	5.27518 (rank : 1572)
Query Neighborhood Hits	1804	Target Neighborhood Hits	243	Shared Neighborhood Hits	18
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

CAF1B_HUMAN
NC score	-0.006079 (rank : 1822)	θ value	6.88961 (rank : 1656)
Query Neighborhood Hits	1804	Target Neighborhood Hits	345	Shared Neighborhood Hits	45
SwissProt Accessions	Q13112, Q99548	Gene names	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7
Domain Architecture
Description	Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) (M- phase phosphoprotein 7).

NGN1_MOUSE
NC score	-0.006155 (rank : 1823)	θ value	6.88961 (rank : 1690)
Query Neighborhood Hits	1804	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

KIF1C_HUMAN
NC score	-0.006159 (rank : 1824)	θ value	5.27518 (rank : 1604)
Query Neighborhood Hits	1804	Target Neighborhood Hits	128	Shared Neighborhood Hits	28
SwissProt Accessions	O43896, O75186	Gene names	KIF1C, KIAA0706
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF1C.

ZN452_HUMAN
NC score	-0.006170 (rank : 1825)	θ value	5.27518 (rank : 1650)
Query Neighborhood Hits	1804	Target Neighborhood Hits	139	Shared Neighborhood Hits	13
SwissProt Accessions	Q6R2W3, Q2NKL9, Q5SRJ3, Q8TCN2, Q96PW3	Gene names	ZNF452, KIAA1925
Domain Architecture	No domain graphic available
Description	Protein ZNF452.

CR2_MOUSE
NC score	-0.006329 (rank : 1826)	θ value	8.99809 (rank : 1736)
Query Neighborhood Hits	1804	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	P19070	Gene names	Cr2
Domain Architecture
Description	Complement receptor type 2 precursor (Cr2) (Complement C3d receptor) (CD21 antigen).

TSH1_HUMAN
NC score	-0.006563 (rank : 1827)	θ value	5.27518 (rank : 1640)
Query Neighborhood Hits	1804	Target Neighborhood Hits	558	Shared Neighborhood Hits	48
SwissProt Accessions	Q6ZSZ6, O60534, Q4LE29, Q53EU4	Gene names	TSHZ1, SDCCAG33, TSH1
Domain Architecture	No domain graphic available
Description	Teashirt homolog 1 (Serologically defined colon cancer antigen 3) (Antigen NY-CO-33).

ADA12_HUMAN
NC score	-0.006601 (rank : 1828)	θ value	8.99809 (rank : 1724)
Query Neighborhood Hits	1804	Target Neighborhood Hits	224	Shared Neighborhood Hits	24
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

AGRIN_HUMAN
NC score	-0.006658 (rank : 1829)	θ value	3.0926 (rank : 1451)
Query Neighborhood Hits	1804	Target Neighborhood Hits	582	Shared Neighborhood Hits	79
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ABCA4_MOUSE
NC score	-0.006954 (rank : 1830)	θ value	5.27518 (rank : 1570)
Query Neighborhood Hits	1804	Target Neighborhood Hits	126	Shared Neighborhood Hits	9
SwissProt Accessions	O35600	Gene names	Abca4, Abcr
Domain Architecture
Description	Retinal-specific ATP-binding cassette transporter (ATP-binding cassette sub-family A member 4) (RIM ABC transporter) (RIM protein) (RmP).

TLE2_HUMAN
NC score	-0.007158 (rank : 1831)	θ value	1.06291 (rank : 1310)
Query Neighborhood Hits	1804	Target Neighborhood Hits	321	Shared Neighborhood Hits	35
SwissProt Accessions	Q04725, Q8WVY0, Q9Y6S0	Gene names	TLE2
Domain Architecture
Description	Transducin-like enhancer protein 2 (ESG2).

ZN687_HUMAN
NC score	-0.007301 (rank : 1832)	θ value	2.36792 (rank : 1449)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1244	Shared Neighborhood Hits	256
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

TMPSD_MOUSE
NC score	-0.007665 (rank : 1833)	θ value	4.03905 (rank : 1563)
Query Neighborhood Hits	1804	Target Neighborhood Hits	334	Shared Neighborhood Hits	81
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

TMPSD_HUMAN
NC score	-0.007834 (rank : 1834)	θ value	2.36792 (rank : 1443)
Query Neighborhood Hits	1804	Target Neighborhood Hits	333	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

PCDA3_HUMAN
NC score	-0.007842 (rank : 1835)	θ value	3.0926 (rank : 1480)
Query Neighborhood Hits	1804	Target Neighborhood Hits	203	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5H8, O75286	Gene names	PCDHA3
Domain Architecture
Description	Protocadherin alpha 3 precursor (PCDH-alpha3).

PCDAB_HUMAN
NC score	-0.008035 (rank : 1836)	θ value	0.813845 (rank : 1266)
Query Neighborhood Hits	1804	Target Neighborhood Hits	211	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y5I1, O75279	Gene names	PCDHA11
Domain Architecture
Description	Protocadherin alpha 11 precursor (PCDH-alpha11).

LRTM3_HUMAN
NC score	-0.008225 (rank : 1837)	θ value	3.0926 (rank : 1471)
Query Neighborhood Hits	1804	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q86VH5, Q6N0A3	Gene names	LRRTM3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PCDA5_HUMAN
NC score	-0.008340 (rank : 1838)	θ value	5.27518 (rank : 1622)
Query Neighborhood Hits	1804	Target Neighborhood Hits	217	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y5H7, O75284, Q8N4R3	Gene names	PCDHA5
Domain Architecture
Description	Protocadherin alpha 5 precursor (PCDH-alpha5).

NR1H2_HUMAN
NC score	-0.008510 (rank : 1839)	θ value	1.81305 (rank : 1382)
Query Neighborhood Hits	1804	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	P55055, Q12970	Gene names	NR1H2, LXRB, NER, UNR
Domain Architecture
Description	Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear orphan receptor LXR-beta) (Ubiquitously-expressed nuclear receptor) (Nuclear receptor NER).

PCDA1_HUMAN
NC score	-0.008540 (rank : 1840)	θ value	5.27518 (rank : 1621)
Query Neighborhood Hits	1804	Target Neighborhood Hits	199	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5I3, O75288, Q9NRT7	Gene names	PCDHA1
Domain Architecture
Description	Protocadherin alpha 1 precursor (PCDH-alpha1).

LRTM3_MOUSE
NC score	-0.008580 (rank : 1841)	θ value	8.99809 (rank : 1761)
Query Neighborhood Hits	1804	Target Neighborhood Hits	290	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BZ81, Q3TQA3, Q8BGJ7	Gene names	Lrrtm3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat transmembrane neuronal protein 3 precursor.

PCDA2_HUMAN
NC score	-0.008941 (rank : 1842)	θ value	8.99809 (rank : 1771)
Query Neighborhood Hits	1804	Target Neighborhood Hits	192	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y5H9, O75287, Q9BTV3	Gene names	PCDHA2
Domain Architecture
Description	Protocadherin alpha 2 precursor (PCDH-alpha2).

PCDA6_HUMAN
NC score	-0.008954 (rank : 1843)	θ value	5.27518 (rank : 1623)
Query Neighborhood Hits	1804	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UN73, O75283, Q9NRT8	Gene names	PCDHA6
Domain Architecture
Description	Protocadherin alpha 6 precursor (PCDH-alpha6).

HXD10_HUMAN
NC score	-0.009576 (rank : 1844)	θ value	0.365318 (rank : 1174)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	P28358	Gene names	HOXD10, HOX4D
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4D) (Hox-4E).

LTB1L_MOUSE
NC score	-0.009628 (rank : 1845)	θ value	6.88961 (rank : 1685)
Query Neighborhood Hits	1804	Target Neighborhood Hits	514	Shared Neighborhood Hits	71
SwissProt Accessions	Q8CG19, O88349, Q8BNW7, Q8C7F5, Q8CIR0	Gene names	Ltbp1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

CDC20_MOUSE
NC score	-0.009692 (rank : 1846)	θ value	4.03905 (rank : 1502)
Query Neighborhood Hits	1804	Target Neighborhood Hits	325	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JJ66, Q3TGP1, Q8BPG4, Q99LK3	Gene names	Cdc20
Domain Architecture
Description	Cell division cycle protein 20 homolog (p55CDC) (mmCdc20).

HXD10_MOUSE
NC score	-0.009753 (rank : 1847)	θ value	0.62314 (rank : 1233)
Query Neighborhood Hits	1804	Target Neighborhood Hits	392	Shared Neighborhood Hits	42
SwissProt Accessions	P28359, Q91WU9	Gene names	Hoxd10, Hox-4.5, Hoxd-10
Domain Architecture
Description	Homeobox protein Hox-D10 (Hox-4.5) (Hox-5.3).

ZN516_MOUSE
NC score	-0.009834 (rank : 1848)	θ value	6.88961 (rank : 1719)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1197	Shared Neighborhood Hits	268
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

NKX61_MOUSE
NC score	-0.010124 (rank : 1849)	θ value	3.0926 (rank : 1479)
Query Neighborhood Hits	1804	Target Neighborhood Hits	439	Shared Neighborhood Hits	61
SwissProt Accessions	Q99MA9, Q9ERQ7	Gene names	Nkx6-1, Nkx6.1, Nkx6a
Domain Architecture
Description	Homeobox protein Nkx-6.1.

HMX3_MOUSE
NC score	-0.010621 (rank : 1850)	θ value	0.0563607 (rank : 1022)
Query Neighborhood Hits	1804	Target Neighborhood Hits	342	Shared Neighborhood Hits	25
SwissProt Accessions	P42581	Gene names	Hmx3, Nkx-5.1, Nkx5-1
Domain Architecture
Description	Homeobox protein HMX3 (Homeobox protein Nkx-5.1).

KLH26_HUMAN
NC score	-0.010637 (rank : 1851)	θ value	0.62314 (rank : 1239)
Query Neighborhood Hits	1804	Target Neighborhood Hits	188	Shared Neighborhood Hits	7
SwissProt Accessions	Q53HC5, Q8TAP0, Q9NUX3	Gene names	KLHL26
Domain Architecture	No domain graphic available
Description	Kelch-like protein 26.

FOG1_HUMAN
NC score	-0.010701 (rank : 1852)	θ value	0.279714 (rank : 1149)
Query Neighborhood Hits	1804	Target Neighborhood Hits	981	Shared Neighborhood Hits	162
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ZFHX2_HUMAN
NC score	-0.010718 (rank : 1853)	θ value	4.03905 (rank : 1568)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1178	Shared Neighborhood Hits	149
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

HXA10_HUMAN
NC score	-0.010840 (rank : 1854)	θ value	0.62314 (rank : 1232)
Query Neighborhood Hits	1804	Target Neighborhood Hits	334	Shared Neighborhood Hits	30
SwissProt Accessions	P31260, O43370, O43605, Q15949	Gene names	HOXA10, HOX1H
Domain Architecture
Description	Homeobox protein Hox-A10 (Hox-1H) (Hox-1.8) (PL).

DLX2_HUMAN
NC score	-0.011216 (rank : 1855)	θ value	0.365318 (rank : 1167)
Query Neighborhood Hits	1804	Target Neighborhood Hits	355	Shared Neighborhood Hits	28
SwissProt Accessions	Q07687	Gene names	DLX2
Domain Architecture
Description	Homeobox protein DLX-2.

DLX2_MOUSE
NC score	-0.011700 (rank : 1856)	θ value	0.47712 (rank : 1197)
Query Neighborhood Hits	1804	Target Neighborhood Hits	352	Shared Neighborhood Hits	24
SwissProt Accessions	P40764	Gene names	Dlx2, Tes-1, Tes1
Domain Architecture
Description	Homeobox protein DLX-2 (Homeobox protein TES-1).

HXC12_MOUSE
NC score	-0.012610 (rank : 1857)	θ value	3.0926 (rank : 1467)
Query Neighborhood Hits	1804	Target Neighborhood Hits	316	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K5B8	Gene names	Hoxc12, Hox-3.8, Hoxc-12
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-C12 (Hox-3.8).

CELR3_HUMAN
NC score	-0.012662 (rank : 1858)	θ value	1.81305 (rank : 1360)
Query Neighborhood Hits	1804	Target Neighborhood Hits	680	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

DLX3_HUMAN
NC score	-0.012700 (rank : 1859)	θ value	5.27518 (rank : 1592)
Query Neighborhood Hits	1804	Target Neighborhood Hits	369	Shared Neighborhood Hits	34
SwissProt Accessions	O60479	Gene names	DLX3
Domain Architecture
Description	Homeobox protein DLX-3.

CELR1_MOUSE
NC score	-0.013152 (rank : 1860)	θ value	0.62314 (rank : 1225)
Query Neighborhood Hits	1804	Target Neighborhood Hits	617	Shared Neighborhood Hits	52
SwissProt Accessions	O35161	Gene names	Celsr1
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor.

ARX_MOUSE
NC score	-0.013252 (rank : 1861)	θ value	5.27518 (rank : 1575)
Query Neighborhood Hits	1804	Target Neighborhood Hits	398	Shared Neighborhood Hits	39
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ARX_HUMAN
NC score	-0.013317 (rank : 1862)	θ value	5.27518 (rank : 1574)
Query Neighborhood Hits	1804	Target Neighborhood Hits	401	Shared Neighborhood Hits	40
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ZEP2_MOUSE
NC score	-0.013927 (rank : 1863)	θ value	2.36792 (rank : 1448)
Query Neighborhood Hits	1804	Target Neighborhood Hits	964	Shared Neighborhood Hits	142
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZN687_MOUSE
NC score	-0.014315 (rank : 1864)	θ value	0.47712 (rank : 1218)
Query Neighborhood Hits	1804	Target Neighborhood Hits	913	Shared Neighborhood Hits	142
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ZN447_HUMAN
NC score	-0.015780 (rank : 1865)	θ value	0.0193708 (rank : 954)
Query Neighborhood Hits	1804	Target Neighborhood Hits	899	Shared Neighborhood Hits	112
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

RRAS_MOUSE
NC score	-0.016055 (rank : 1866)	θ value	8.99809 (rank : 1779)
Query Neighborhood Hits	1804	Target Neighborhood Hits	272	Shared Neighborhood Hits	8
SwissProt Accessions	P10833	Gene names	Rras
Domain Architecture
Description	Ras-related protein R-Ras (P23).

RREB1_HUMAN
NC score	-0.016400 (rank : 1867)	θ value	0.0193708 (rank : 949)
Query Neighborhood Hits	1804	Target Neighborhood Hits	879	Shared Neighborhood Hits	122
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

ZN217_HUMAN
NC score	-0.017357 (rank : 1868)	θ value	0.21417 (rank : 1139)
Query Neighborhood Hits	1804	Target Neighborhood Hits	905	Shared Neighborhood Hits	141
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

MTR1L_HUMAN
NC score	-0.017390 (rank : 1869)	θ value	0.0736092 (rank : 1039)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1180	Shared Neighborhood Hits	140
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

INSM1_HUMAN
NC score	-0.018402 (rank : 1870)	θ value	0.62314 (rank : 1235)
Query Neighborhood Hits	1804	Target Neighborhood Hits	683	Shared Neighborhood Hits	50
SwissProt Accessions	Q01101	Gene names	INSM1, IA1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

GLI2_HUMAN
NC score	-0.018534 (rank : 1871)	θ value	0.813845 (rank : 1262)
Query Neighborhood Hits	1804	Target Neighborhood Hits	971	Shared Neighborhood Hits	153
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

GLIS3_MOUSE
NC score	-0.019145 (rank : 1872)	θ value	0.0148317 (rank : 931)
Query Neighborhood Hits	1804	Target Neighborhood Hits	861	Shared Neighborhood Hits	121
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

KLF17_HUMAN
NC score	-0.020793 (rank : 1873)	θ value	5.27518 (rank : 1606)
Query Neighborhood Hits	1804	Target Neighborhood Hits	882	Shared Neighborhood Hits	125
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

ZBTB4_HUMAN
NC score	-0.021751 (rank : 1874)	θ value	1.81305 (rank : 1405)
Query Neighborhood Hits	1804	Target Neighborhood Hits	926	Shared Neighborhood Hits	102
SwissProt Accessions	Q9P1Z0, Q7Z697, Q86XJ4, Q8N4V8	Gene names	ZBTB4, KIAA1538
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1).

ZN142_HUMAN
NC score	-0.021833 (rank : 1875)	θ value	0.163984 (rank : 1115)
Query Neighborhood Hits	1804	Target Neighborhood Hits	1007	Shared Neighborhood Hits	145
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZIC5_HUMAN
NC score	-0.022848 (rank : 1876)	θ value	0.47712 (rank : 1217)
Query Neighborhood Hits	1804	Target Neighborhood Hits	774	Shared Neighborhood Hits	66
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZFP91_HUMAN
NC score	-0.023737 (rank : 1877)	θ value	0.279714 (rank : 1160)
Query Neighborhood Hits	1804	Target Neighborhood Hits	769	Shared Neighborhood Hits	62
SwissProt Accessions	Q96JP5, Q86V47, Q96JP4, Q96QA3	Gene names	ZFP91
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 homolog (Zfp-91).

GLIS3_HUMAN
NC score	-0.024062 (rank : 1878)	θ value	6.88961 (rank : 1676)
Query Neighborhood Hits	1804	Target Neighborhood Hits	758	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEA6	Gene names	GLIS3, ZNF515
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3) (Zinc finger protein 515).

BCL6_MOUSE
NC score	-0.024991 (rank : 1879)	θ value	4.03905 (rank : 1499)
Query Neighborhood Hits	1804	Target Neighborhood Hits	913	Shared Neighborhood Hits	96
SwissProt Accessions	P41183, Q61065	Gene names	Bcl6, Bcl-6
Domain Architecture
Description	B-cell lymphoma 6 protein homolog.

KLF13_MOUSE
NC score	-0.025091 (rank : 1880)	θ value	2.36792 (rank : 1430)
Query Neighborhood Hits	1804	Target Neighborhood Hits	757	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JJZ6, Q9ESX3, Q9JHF8	Gene names	Klf13, Bteb3, Fklf2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Erythroid transcription factor FKLF-2).

ADA2A_MOUSE
NC score	-0.025133 (rank : 1881)	θ value	0.163984 (rank : 1085)
Query Neighborhood Hits	1804	Target Neighborhood Hits	900	Shared Neighborhood Hits	32
SwissProt Accessions	Q01338	Gene names	Adra2a
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR).

ZFP91_MOUSE
NC score	-0.025310 (rank : 1882)	θ value	3.0926 (rank : 1494)
Query Neighborhood Hits	1804	Target Neighborhood Hits	742	Shared Neighborhood Hits	46
SwissProt Accessions	Q62511, Q8BPY3, Q8C2B4	Gene names	Zfp91, Pzf
Domain Architecture	No domain graphic available
Description	Zinc finger protein 91 (Zfp-91) (Zinc finger protein PZF) (Penta Zf protein).

ADA2A_HUMAN
NC score	-0.025329 (rank : 1883)	θ value	0.62314 (rank : 1220)
Query Neighborhood Hits	1804	Target Neighborhood Hits	911	Shared Neighborhood Hits	33
SwissProt Accessions	P08913, Q2XN99, Q86TH8, Q9BZK1	Gene names	ADRA2A, ADRA2R, ADRAR
Domain Architecture
Description	Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2A adrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtype C10).

KLF16_HUMAN
NC score	-0.025482 (rank : 1884)	θ value	5.27518 (rank : 1605)
Query Neighborhood Hits	1804	Target Neighborhood Hits	737	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BXK1	Gene names	KLF16, BTEB4, NSLP2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor NSLP2).

ACM4_MOUSE
NC score	-0.025845 (rank : 1885)	θ value	5.27518 (rank : 1571)
Query Neighborhood Hits	1804	Target Neighborhood Hits	894	Shared Neighborhood Hits	22
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).

ZN553_HUMAN
NC score	-0.026176 (rank : 1886)	θ value	6.88961 (rank : 1720)
Query Neighborhood Hits	1804	Target Neighborhood Hits	760	Shared Neighborhood Hits	48
SwissProt Accessions	Q96MX3, Q4G0R3, Q69YP3, Q96IL9	Gene names	ZNF553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ZN553_MOUSE
NC score	-0.026338 (rank : 1887)	θ value	8.99809 (rank : 1804)
Query Neighborhood Hits	1804	Target Neighborhood Hits	744	Shared Neighborhood Hits	45
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ADA1B_HUMAN
NC score	-0.028806 (rank : 1888)	θ value	6.88961 (rank : 1651)
Query Neighborhood Hits	1804	Target Neighborhood Hits	978	Shared Neighborhood Hits	20
SwissProt Accessions	P35368	Gene names	ADRA1B
Domain Architecture
Description	Alpha-1B adrenergic receptor (Alpha 1B-adrenoceptor) (Alpha 1B- adrenoreceptor).