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Network neighborhood for query Sequence : KCNH2_HUMAN

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KCNH2_HUMAN
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

KCNH2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	158	Target Neighborhood Hits	158	Shared Neighborhood Hits	158
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	0 (rank : 2)	NC score	0.995949 (rank : 2)
Query Neighborhood Hits	158	Target Neighborhood Hits	165	Shared Neighborhood Hits	110
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH6_HUMAN
θ value	0 (rank : 3)	NC score	0.979253 (rank : 5)
Query Neighborhood Hits	158	Target Neighborhood Hits	222	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH7_HUMAN
θ value	0 (rank : 4)	NC score	0.988809 (rank : 4)
Query Neighborhood Hits	158	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH7_MOUSE
θ value	0 (rank : 5)	NC score	0.989521 (rank : 3)
Query Neighborhood Hits	158	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH8_HUMAN
θ value	4.75757e-126 (rank : 6)	NC score	0.960370 (rank : 6)
Query Neighborhood Hits	158	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH5_HUMAN
θ value	3.19119e-122 (rank : 7)	NC score	0.954467 (rank : 8)
Query Neighborhood Hits	158	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	7.10925e-122 (rank : 8)	NC score	0.954225 (rank : 9)
Query Neighborhood Hits	158	Target Neighborhood Hits	102	Shared Neighborhood Hits	57
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH1_HUMAN
θ value	1.21265e-121 (rank : 9)	NC score	0.953508 (rank : 11)
Query Neighborhood Hits	158	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	1.58377e-121 (rank : 10)	NC score	0.953719 (rank : 10)
Query Neighborhood Hits	158	Target Neighborhood Hits	94	Shared Neighborhood Hits	59
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH4_HUMAN
θ value	6.01832e-121 (rank : 11)	NC score	0.957521 (rank : 7)
Query Neighborhood Hits	158	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH3_MOUSE
θ value	2.29227e-112 (rank : 12)	NC score	0.951447 (rank : 13)
Query Neighborhood Hits	158	Target Neighborhood Hits	133	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH3_HUMAN
θ value	2.9938e-112 (rank : 13)	NC score	0.951879 (rank : 12)
Query Neighborhood Hits	158	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

HCN4_HUMAN
θ value	1.98146e-39 (rank : 14)	NC score	0.792173 (rank : 24)
Query Neighborhood Hits	158	Target Neighborhood Hits	303	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN2_HUMAN
θ value	9.83387e-39 (rank : 15)	NC score	0.788487 (rank : 26)
Query Neighborhood Hits	158	Target Neighborhood Hits	369	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN3_HUMAN
θ value	1.28434e-38 (rank : 16)	NC score	0.805448 (rank : 20)
Query Neighborhood Hits	158	Target Neighborhood Hits	99	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN2_MOUSE
θ value	2.19075e-38 (rank : 17)	NC score	0.795386 (rank : 23)
Query Neighborhood Hits	158	Target Neighborhood Hits	278	Shared Neighborhood Hits	58
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_MOUSE
θ value	2.19075e-38 (rank : 18)	NC score	0.790299 (rank : 25)
Query Neighborhood Hits	158	Target Neighborhood Hits	284	Shared Neighborhood Hits	56
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN1_HUMAN
θ value	2.86122e-38 (rank : 19)	NC score	0.808720 (rank : 18)
Query Neighborhood Hits	158	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	2.86122e-38 (rank : 20)	NC score	0.804862 (rank : 22)
Query Neighborhood Hits	158	Target Neighborhood Hits	172	Shared Neighborhood Hits	46
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_MOUSE
θ value	4.88048e-38 (rank : 21)	NC score	0.805358 (rank : 21)
Query Neighborhood Hits	158	Target Neighborhood Hits	112	Shared Neighborhood Hits	40
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

CNGA3_HUMAN
θ value	2.67802e-36 (rank : 22)	NC score	0.808740 (rank : 17)
Query Neighborhood Hits	158	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	3.86705e-35 (rank : 23)	NC score	0.822833 (rank : 14)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_MOUSE
θ value	1.12514e-34 (rank : 24)	NC score	0.811748 (rank : 16)
Query Neighborhood Hits	158	Target Neighborhood Hits	84	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
θ value	5.584e-34 (rank : 25)	NC score	0.812051 (rank : 15)
Query Neighborhood Hits	158	Target Neighborhood Hits	149	Shared Neighborhood Hits	38
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	2.12192e-33 (rank : 26)	NC score	0.807246 (rank : 19)
Query Neighborhood Hits	158	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGB3_MOUSE
θ value	2.87452e-22 (rank : 27)	NC score	0.754483 (rank : 27)
Query Neighborhood Hits	158	Target Neighborhood Hits	74	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
θ value	2.27762e-19 (rank : 28)	NC score	0.739519 (rank : 28)
Query Neighborhood Hits	158	Target Neighborhood Hits	206	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
θ value	5.60996e-18 (rank : 29)	NC score	0.732789 (rank : 29)
Query Neighborhood Hits	158	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNKH_HUMAN
θ value	0.00298849 (rank : 30)	NC score	0.247086 (rank : 30)
Query Neighborhood Hits	158	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

KCNK2_HUMAN
θ value	0.0113563 (rank : 31)	NC score	0.184076 (rank : 32)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	0.0113563 (rank : 32)	NC score	0.183439 (rank : 33)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNKF_HUMAN
θ value	0.0113563 (rank : 33)	NC score	0.188406 (rank : 31)
Query Neighborhood Hits	158	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

SCN7A_HUMAN
θ value	0.0252991 (rank : 34)	NC score	0.018011 (rank : 110)
Query Neighborhood Hits	158	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

ZN516_MOUSE
θ value	0.0563607 (rank : 35)	NC score	0.009483 (rank : 134)
Query Neighborhood Hits	158	Target Neighborhood Hits	1197	Shared Neighborhood Hits	30
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CA106_MOUSE
θ value	0.0736092 (rank : 36)	NC score	0.032919 (rank : 84)
Query Neighborhood Hits	158	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

HSF1_HUMAN
θ value	0.0736092 (rank : 37)	NC score	0.035228 (rank : 82)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

KCNKA_HUMAN
θ value	0.0736092 (rank : 38)	NC score	0.174277 (rank : 35)
Query Neighborhood Hits	158	Target Neighborhood Hits	111	Shared Neighborhood Hits	46
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

OGFR_HUMAN
θ value	0.0736092 (rank : 39)	NC score	0.040324 (rank : 77)
Query Neighborhood Hits	158	Target Neighborhood Hits	1582	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CP007_MOUSE
θ value	0.0961366 (rank : 40)	NC score	0.030492 (rank : 91)
Query Neighborhood Hits	158	Target Neighborhood Hits	231	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

KCND1_MOUSE
θ value	0.0961366 (rank : 41)	NC score	0.066273 (rank : 59)
Query Neighborhood Hits	158	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCNK3_HUMAN
θ value	0.0961366 (rank : 42)	NC score	0.175650 (rank : 34)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK6_HUMAN
θ value	0.0961366 (rank : 43)	NC score	0.173704 (rank : 36)
Query Neighborhood Hits	158	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_MOUSE
θ value	0.163984 (rank : 44)	NC score	0.171969 (rank : 37)
Query Neighborhood Hits	158	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

NRX2A_HUMAN
θ value	0.163984 (rank : 45)	NC score	0.028925 (rank : 93)
Query Neighborhood Hits	158	Target Neighborhood Hits	614	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.163984 (rank : 46)	NC score	0.043157 (rank : 74)
Query Neighborhood Hits	158	Target Neighborhood Hits	481	Shared Neighborhood Hits	18
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

CEBPE_MOUSE
θ value	0.21417 (rank : 47)	NC score	0.025920 (rank : 99)
Query Neighborhood Hits	158	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PZD9	Gene names	Cebpe
Domain Architecture	No domain graphic available
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

KGP1A_HUMAN
θ value	0.279714 (rank : 48)	NC score	0.044526 (rank : 71)
Query Neighborhood Hits	158	Target Neighborhood Hits	901	Shared Neighborhood Hits	43
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.279714 (rank : 49)	NC score	0.044627 (rank : 70)
Query Neighborhood Hits	158	Target Neighborhood Hits	921	Shared Neighborhood Hits	44
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

FRS3_MOUSE
θ value	0.365318 (rank : 50)	NC score	0.026018 (rank : 98)
Query Neighborhood Hits	158	Target Neighborhood Hits	168	Shared Neighborhood Hits	10
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

HSF1_MOUSE
θ value	0.365318 (rank : 51)	NC score	0.037579 (rank : 80)
Query Neighborhood Hits	158	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

KCND2_HUMAN
θ value	0.365318 (rank : 52)	NC score	0.058781 (rank : 63)
Query Neighborhood Hits	158	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.365318 (rank : 53)	NC score	0.058770 (rank : 64)
Query Neighborhood Hits	158	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

NFH_MOUSE
θ value	0.365318 (rank : 54)	NC score	0.019791 (rank : 108)
Query Neighborhood Hits	158	Target Neighborhood Hits	2247	Shared Neighborhood Hits	55
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RGS3_MOUSE
θ value	0.365318 (rank : 55)	NC score	0.036713 (rank : 81)
Query Neighborhood Hits	158	Target Neighborhood Hits	1621	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TOPRS_MOUSE
θ value	0.365318 (rank : 56)	NC score	0.024936 (rank : 101)
Query Neighborhood Hits	158	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

KCND1_HUMAN
θ value	0.47712 (rank : 57)	NC score	0.060326 (rank : 60)
Query Neighborhood Hits	158	Target Neighborhood Hits	160	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNK4_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.163786 (rank : 38)
Query Neighborhood Hits	158	Target Neighborhood Hits	109	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNK4_MOUSE
θ value	0.47712 (rank : 59)	NC score	0.152788 (rank : 41)
Query Neighborhood Hits	158	Target Neighborhood Hits	118	Shared Neighborhood Hits	50
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

NCA11_MOUSE
θ value	0.47712 (rank : 60)	NC score	0.010187 (rank : 133)
Query Neighborhood Hits	158	Target Neighborhood Hits	661	Shared Neighborhood Hits	20
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

CEBPE_HUMAN
θ value	0.62314 (rank : 61)	NC score	0.031570 (rank : 89)
Query Neighborhood Hits	158	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

KAP0_MOUSE
θ value	0.62314 (rank : 62)	NC score	0.144987 (rank : 44)
Query Neighborhood Hits	158	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KGP1B_MOUSE
θ value	0.62314 (rank : 63)	NC score	0.044174 (rank : 72)
Query Neighborhood Hits	158	Target Neighborhood Hits	922	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

NRG2_HUMAN
θ value	0.62314 (rank : 64)	NC score	0.024838 (rank : 102)
Query Neighborhood Hits	158	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

SF3B1_HUMAN
θ value	0.62314 (rank : 65)	NC score	0.032224 (rank : 86)
Query Neighborhood Hits	158	Target Neighborhood Hits	341	Shared Neighborhood Hits	18
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.032217 (rank : 87)
Query Neighborhood Hits	158	Target Neighborhood Hits	352	Shared Neighborhood Hits	19
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

KAP0_HUMAN
θ value	0.813845 (rank : 67)	NC score	0.156355 (rank : 40)
Query Neighborhood Hits	158	Target Neighborhood Hits	52	Shared Neighborhood Hits	32
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KCNK9_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.146953 (rank : 43)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPC2, Q2M290, Q540F2	Gene names	KCNK9, TASK3
Domain Architecture
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2).

KCNK9_MOUSE
θ value	0.813845 (rank : 69)	NC score	0.147096 (rank : 42)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q3LS21	Gene names	Kcnk9, Task3
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3).

KCNKD_MOUSE
θ value	0.813845 (rank : 70)	NC score	0.101172 (rank : 50)
Query Neighborhood Hits	158	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1P5	Gene names	Kcnk13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

PSL1_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.041089 (rank : 75)
Query Neighborhood Hits	158	Target Neighborhood Hits	650	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

FOG1_MOUSE
θ value	1.06291 (rank : 72)	NC score	0.006144 (rank : 143)
Query Neighborhood Hits	158	Target Neighborhood Hits	1237	Shared Neighborhood Hits	37
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

FRS3_HUMAN
θ value	1.06291 (rank : 73)	NC score	0.022513 (rank : 104)
Query Neighborhood Hits	158	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

GP124_MOUSE
θ value	1.06291 (rank : 74)	NC score	0.007452 (rank : 141)
Query Neighborhood Hits	158	Target Neighborhood Hits	423	Shared Neighborhood Hits	6
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

LYSM2_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.021117 (rank : 106)
Query Neighborhood Hits	158	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV50, Q5CZ88, Q8WTV3	Gene names	LYSMD2
Domain Architecture	No domain graphic available
Description	LysM and putative peptidoglycan-binding domain-containing protein 2.

NRG2_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.025312 (rank : 100)
Query Neighborhood Hits	158	Target Neighborhood Hits	392	Shared Neighborhood Hits	6
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

CUTL2_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.009421 (rank : 135)
Query Neighborhood Hits	158	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

KCNKG_HUMAN
θ value	1.38821 (rank : 78)	NC score	0.160715 (rank : 39)
Query Neighborhood Hits	158	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

PKP3_HUMAN
θ value	1.38821 (rank : 79)	NC score	0.008671 (rank : 136)
Query Neighborhood Hits	158	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

RGS3_HUMAN
θ value	1.38821 (rank : 80)	NC score	0.027393 (rank : 95)
Query Neighborhood Hits	158	Target Neighborhood Hits	1375	Shared Neighborhood Hits	45
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

FOXN1_HUMAN
θ value	1.81305 (rank : 81)	NC score	0.017259 (rank : 111)
Query Neighborhood Hits	158	Target Neighborhood Hits	377	Shared Neighborhood Hits	22
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

KCNK1_HUMAN
θ value	1.81305 (rank : 82)	NC score	0.124842 (rank : 47)
Query Neighborhood Hits	158	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O00180, Q13307	Gene names	KCNK1, HOHO1, KCNO1, TWIK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1).

MAGE1_HUMAN
θ value	1.81305 (rank : 83)	NC score	0.031591 (rank : 88)
Query Neighborhood Hits	158	Target Neighborhood Hits	1389	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MNAB_HUMAN
θ value	1.81305 (rank : 84)	NC score	0.013768 (rank : 120)
Query Neighborhood Hits	158	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

RERE_MOUSE
θ value	1.81305 (rank : 85)	NC score	0.013620 (rank : 121)
Query Neighborhood Hits	158	Target Neighborhood Hits	785	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

KAP1_HUMAN
θ value	2.36792 (rank : 86)	NC score	0.131878 (rank : 45)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	2.36792 (rank : 87)	NC score	0.129577 (rank : 46)
Query Neighborhood Hits	158	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KCND3_HUMAN
θ value	2.36792 (rank : 88)	NC score	0.055458 (rank : 66)
Query Neighborhood Hits	158	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	2.36792 (rank : 89)	NC score	0.055471 (rank : 65)
Query Neighborhood Hits	158	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNK5_HUMAN
θ value	2.36792 (rank : 90)	NC score	0.123855 (rank : 48)
Query Neighborhood Hits	158	Target Neighborhood Hits	102	Shared Neighborhood Hits	48
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

MAST4_HUMAN
θ value	2.36792 (rank : 91)	NC score	0.004967 (rank : 145)
Query Neighborhood Hits	158	Target Neighborhood Hits	1804	Shared Neighborhood Hits	43
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PDZD2_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.020482 (rank : 107)
Query Neighborhood Hits	158	Target Neighborhood Hits	772	Shared Neighborhood Hits	30
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

RGS14_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.014110 (rank : 119)
Query Neighborhood Hits	158	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

SRRM1_HUMAN
θ value	2.36792 (rank : 94)	NC score	0.029905 (rank : 92)
Query Neighborhood Hits	158	Target Neighborhood Hits	690	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TAF4_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.024612 (rank : 103)
Query Neighborhood Hits	158	Target Neighborhood Hits	687	Shared Neighborhood Hits	30
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

ATPD_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.027400 (rank : 94)
Query Neighborhood Hits	158	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P30049	Gene names	ATP5D
Domain Architecture
Description	ATP synthase delta chain, mitochondrial precursor (EC 3.6.3.14).

ENAH_MOUSE
θ value	3.0926 (rank : 97)	NC score	0.012646 (rank : 123)
Query Neighborhood Hits	158	Target Neighborhood Hits	919	Shared Neighborhood Hits	31
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

KCMA1_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.059908 (rank : 62)
Query Neighborhood Hits	158	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCMA1_MOUSE
θ value	3.0926 (rank : 99)	NC score	0.060016 (rank : 61)
Query Neighborhood Hits	158	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCNK1_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.120183 (rank : 49)
Query Neighborhood Hits	158	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O08581	Gene names	Kcnk1
Domain Architecture
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1).

KCNQ2_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.040954 (rank : 76)
Query Neighborhood Hits	158	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
θ value	3.0926 (rank : 102)	NC score	0.040031 (rank : 78)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_MOUSE
θ value	3.0926 (rank : 103)	NC score	0.055277 (rank : 67)
Query Neighborhood Hits	158	Target Neighborhood Hits	105	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

MTMR3_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.004243 (rank : 152)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

SEZ6L_HUMAN
θ value	3.0926 (rank : 105)	NC score	0.006568 (rank : 142)
Query Neighborhood Hits	158	Target Neighborhood Hits	289	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

TSSC4_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.014807 (rank : 116)
Query Neighborhood Hits	158	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5U2, Q86VL2, Q9BRS6	Gene names	TSSC4
Domain Architecture	No domain graphic available
Description	Protein TSSC4 (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) (Tumor-suppressing STF cDNA 4 protein).

ZBT16_HUMAN
θ value	3.0926 (rank : 107)	NC score	-0.003559 (rank : 165)
Query Neighborhood Hits	158	Target Neighborhood Hits	1010	Shared Neighborhood Hits	10
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

ZP1_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.014278 (rank : 118)
Query Neighborhood Hits	158	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

ANR25_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.004583 (rank : 149)
Query Neighborhood Hits	158	Target Neighborhood Hits	350	Shared Neighborhood Hits	11
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

CQ10A_HUMAN
θ value	4.03905 (rank : 110)	NC score	0.011010 (rank : 131)
Query Neighborhood Hits	158	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MF6, Q6GMR6, Q6UWB9, Q86X16, Q96MF1, Q9BUP4	Gene names	COQ10A
Domain Architecture	No domain graphic available
Description	Protein COQ10 A, mitochondrial precursor.

HXB5_HUMAN
θ value	4.03905 (rank : 111)	NC score	-0.000423 (rank : 159)
Query Neighborhood Hits	158	Target Neighborhood Hits	332	Shared Neighborhood Hits	4
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

KCNKC_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.078281 (rank : 56)
Query Neighborhood Hits	158	Target Neighborhood Hits	51	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB15	Gene names	KCNK12
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 12 (Tandem pore domain halothane- inhibited potassium channel 2) (THIK-2).

MAST1_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.001724 (rank : 158)
Query Neighborhood Hits	158	Target Neighborhood Hits	1123	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MY18B_HUMAN
θ value	4.03905 (rank : 114)	NC score	0.005168 (rank : 144)
Query Neighborhood Hits	158	Target Neighborhood Hits	1299	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NCOA6_HUMAN
θ value	4.03905 (rank : 115)	NC score	0.027363 (rank : 96)
Query Neighborhood Hits	158	Target Neighborhood Hits	1202	Shared Neighborhood Hits	45
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RP1L1_MOUSE
θ value	4.03905 (rank : 116)	NC score	0.012349 (rank : 124)
Query Neighborhood Hits	158	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

RPGF4_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.039529 (rank : 79)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	4.03905 (rank : 118)	NC score	0.043619 (rank : 73)
Query Neighborhood Hits	158	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

XYLT1_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.007499 (rank : 140)
Query Neighborhood Hits	158	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	Q86Y38, Q9H1B6	Gene names	XYLT1, XT1
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 1 (EC 2.4.2.26) (Xylosyltransferase I) (XylT-I) (XT-I) (Peptide O-xylosyltransferase 1).

3BHS7_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.011101 (rank : 130)
Query Neighborhood Hits	158	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

ATG9A_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.011296 (rank : 128)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3C6, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7	Gene names	ATG9A, APG9L1
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 9A (APG9-like 1).

CN004_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.013326 (rank : 122)
Query Neighborhood Hits	158	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

DCAK2_MOUSE
θ value	5.27518 (rank : 123)	NC score	-0.002051 (rank : 162)
Query Neighborhood Hits	158	Target Neighborhood Hits	858	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

EMSY_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.014944 (rank : 115)
Query Neighborhood Hits	158	Target Neighborhood Hits	294	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

KCNKD_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.080348 (rank : 55)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB14, Q96E79	Gene names	KCNK13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KCNN4_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.034334 (rank : 83)
Query Neighborhood Hits	158	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	O15554	Gene names	KCNN4, IK1, IKCA1, KCA4, SK4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1) (IKCa1) (Putative Gardos channel).

M3K10_HUMAN
θ value	5.27518 (rank : 127)	NC score	-0.002484 (rank : 163)
Query Neighborhood Hits	158	Target Neighborhood Hits	1071	Shared Neighborhood Hits	15
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MEFV_HUMAN
θ value	5.27518 (rank : 128)	NC score	0.001896 (rank : 157)
Query Neighborhood Hits	158	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

NACAM_MOUSE
θ value	5.27518 (rank : 129)	NC score	0.032577 (rank : 85)
Query Neighborhood Hits	158	Target Neighborhood Hits	1866	Shared Neighborhood Hits	54
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SRRM1_MOUSE
θ value	5.27518 (rank : 130)	NC score	0.026803 (rank : 97)
Query Neighborhood Hits	158	Target Neighborhood Hits	966	Shared Neighborhood Hits	42
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

CI150_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.019266 (rank : 109)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2P1, Q9D150	Gene names	D4Bwg0951e
Domain Architecture	No domain graphic available
Description	Protein C9orf150 homolog.

GLI1_HUMAN
θ value	6.88961 (rank : 132)	NC score	-0.000953 (rank : 160)
Query Neighborhood Hits	158	Target Neighborhood Hits	828	Shared Neighborhood Hits	13
SwissProt Accessions	P08151, Q8TDN9	Gene names	GLI1, GLI
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI).

IRS2_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.010324 (rank : 132)
Query Neighborhood Hits	158	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

KCNN4_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.030975 (rank : 90)
Query Neighborhood Hits	158	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	O89109, Q3U1J8, Q9CY39	Gene names	Kcnn4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1).

KCNQ3_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.053144 (rank : 69)
Query Neighborhood Hits	158	Target Neighborhood Hits	114	Shared Neighborhood Hits	40
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

RECQ4_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.004601 (rank : 148)
Query Neighborhood Hits	158	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

REL1_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.015642 (rank : 112)
Query Neighborhood Hits	158	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

SNPC4_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.022432 (rank : 105)
Query Neighborhood Hits	158	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

TASP1_MOUSE
θ value	6.88961 (rank : 139)	NC score	0.007546 (rank : 139)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1G1, Q99JP3	Gene names	Tasp1
Domain Architecture
Description	Threonine aspartase 1 (EC 3.4.25.-) (Taspase-1) [Contains: Threonine aspartase subunit alpha; Threonine aspartase subunit beta].

TBCD1_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.003637 (rank : 153)
Query Neighborhood Hits	158	Target Neighborhood Hits	241	Shared Neighborhood Hits	4
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

TGIF_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.004251 (rank : 151)
Query Neighborhood Hits	158	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q15583, Q6ICR0, Q8N5X9, Q9NRS0	Gene names	TGIF
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

TOPRS_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.015506 (rank : 113)
Query Neighborhood Hits	158	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

ZNF31_HUMAN
θ value	6.88961 (rank : 143)	NC score	-0.003036 (rank : 164)
Query Neighborhood Hits	158	Target Neighborhood Hits	769	Shared Neighborhood Hits	7
SwissProt Accessions	P17040, Q96H84	Gene names	ZNF31, KOX29, ZNF360, ZSCAN20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 31 (Zinc finger protein KOX29) (Zinc finger and SCAN domain-containing protein 20) (Zinc finger protein 360).

ABD12_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.011697 (rank : 125)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N2K0, Q5T710, Q96CR1, Q9BX05, Q9NPX7, Q9UFV6	Gene names	Abhd12, C20orf22
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

ABD12_MOUSE
θ value	8.99809 (rank : 145)	NC score	0.011691 (rank : 126)
Query Neighborhood Hits	158	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LR1, Q99M06	Gene names	Abhd12
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

AF17_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.011179 (rank : 129)
Query Neighborhood Hits	158	Target Neighborhood Hits	230	Shared Neighborhood Hits	13
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

AFF1_MOUSE
θ value	8.99809 (rank : 147)	NC score	0.014401 (rank : 117)
Query Neighborhood Hits	158	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CC054_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.007833 (rank : 137)
Query Neighborhood Hits	158	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EL1	Gene names	C3orf54
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf54.

CN004_MOUSE
θ value	8.99809 (rank : 149)	NC score	0.011628 (rank : 127)
Query Neighborhood Hits	158	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

LDB3_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.003270 (rank : 154)
Query Neighborhood Hits	158	Target Neighborhood Hits	497	Shared Neighborhood Hits	20
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

MARK2_HUMAN
θ value	8.99809 (rank : 151)	NC score	-0.000957 (rank : 161)
Query Neighborhood Hits	158	Target Neighborhood Hits	1056	Shared Neighborhood Hits	22
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PITM1_MOUSE
θ value	8.99809 (rank : 152)	NC score	0.003002 (rank : 156)
Query Neighborhood Hits	158	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

SOCS7_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.007756 (rank : 138)
Query Neighborhood Hits	158	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SVIL_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.004758 (rank : 147)
Query Neighborhood Hits	158	Target Neighborhood Hits	439	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TIF1G_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.003141 (rank : 155)
Query Neighborhood Hits	158	Target Neighborhood Hits	410	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TIF1G_MOUSE
θ value	8.99809 (rank : 156)	NC score	0.004475 (rank : 150)
Query Neighborhood Hits	158	Target Neighborhood Hits	498	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TOM40_HUMAN
θ value	8.99809 (rank : 157)	NC score	0.004862 (rank : 146)
Query Neighborhood Hits	158	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	O96008, Q86VW4, Q8WY09, Q8WY10, Q8WY11, Q9BR95	Gene names	TOMM40, PEREC1, TOM40
Domain Architecture
Description	Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5).

VASP_MOUSE
θ value	8.99809 (rank : 158)	NC score	0.015468 (rank : 114)
Query Neighborhood Hits	158	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

CT152_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.068259 (rank : 58)
Query Neighborhood Hits	158	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KAP2_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.090259 (rank : 53)
Query Neighborhood Hits	158	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.092409 (rank : 52)
Query Neighborhood Hits	158	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.089474 (rank : 54)
Query Neighborhood Hits	158	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.092842 (rank : 51)
Query Neighborhood Hits	158	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KCNK7_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.053513 (rank : 68)
Query Neighborhood Hits	158	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2U2, Q9Y2U3, Q9Y2U4	Gene names	KCNK7
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7.

KCNK7_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.070812 (rank : 57)
Query Neighborhood Hits	158	Target Neighborhood Hits	53	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

Hits sorted by NC score

KCNH2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	158	Target Neighborhood Hits	158	Shared Neighborhood Hits	158
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
NC score	0.995949 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	158	Target Neighborhood Hits	165	Shared Neighborhood Hits	110
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH7_MOUSE
NC score	0.989521 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	158	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH7_HUMAN
NC score	0.988809 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	158	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH6_HUMAN
NC score	0.979253 (rank : 5)	θ value	0 (rank : 3)
Query Neighborhood Hits	158	Target Neighborhood Hits	222	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH8_HUMAN
NC score	0.960370 (rank : 6)	θ value	4.75757e-126 (rank : 6)
Query Neighborhood Hits	158	Target Neighborhood Hits	104	Shared Neighborhood Hits	58
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH4_HUMAN
NC score	0.957521 (rank : 7)	θ value	6.01832e-121 (rank : 11)
Query Neighborhood Hits	158	Target Neighborhood Hits	177	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH5_HUMAN
NC score	0.954467 (rank : 8)	θ value	3.19119e-122 (rank : 7)
Query Neighborhood Hits	158	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
NC score	0.954225 (rank : 9)	θ value	7.10925e-122 (rank : 8)
Query Neighborhood Hits	158	Target Neighborhood Hits	102	Shared Neighborhood Hits	57
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH1_MOUSE
NC score	0.953719 (rank : 10)	θ value	1.58377e-121 (rank : 10)
Query Neighborhood Hits	158	Target Neighborhood Hits	94	Shared Neighborhood Hits	59
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.953508 (rank : 11)	θ value	1.21265e-121 (rank : 9)
Query Neighborhood Hits	158	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH3_HUMAN
NC score	0.951879 (rank : 12)	θ value	2.9938e-112 (rank : 13)
Query Neighborhood Hits	158	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.951447 (rank : 13)	θ value	2.29227e-112 (rank : 12)
Query Neighborhood Hits	158	Target Neighborhood Hits	133	Shared Neighborhood Hits	58
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

CNGA2_MOUSE
NC score	0.822833 (rank : 14)	θ value	3.86705e-35 (rank : 23)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	42
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_HUMAN
NC score	0.812051 (rank : 15)	θ value	5.584e-34 (rank : 25)
Query Neighborhood Hits	158	Target Neighborhood Hits	149	Shared Neighborhood Hits	38
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
NC score	0.811748 (rank : 16)	θ value	1.12514e-34 (rank : 24)
Query Neighborhood Hits	158	Target Neighborhood Hits	84	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.808740 (rank : 17)	θ value	2.67802e-36 (rank : 22)
Query Neighborhood Hits	158	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

HCN1_HUMAN
NC score	0.808720 (rank : 18)	θ value	2.86122e-38 (rank : 19)
Query Neighborhood Hits	158	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

CNGA1_MOUSE
NC score	0.807246 (rank : 19)	θ value	2.12192e-33 (rank : 26)
Query Neighborhood Hits	158	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

HCN3_HUMAN
NC score	0.805448 (rank : 20)	θ value	1.28434e-38 (rank : 16)
Query Neighborhood Hits	158	Target Neighborhood Hits	99	Shared Neighborhood Hits	42
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
NC score	0.805358 (rank : 21)	θ value	4.88048e-38 (rank : 21)
Query Neighborhood Hits	158	Target Neighborhood Hits	112	Shared Neighborhood Hits	40
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_MOUSE
NC score	0.804862 (rank : 22)	θ value	2.86122e-38 (rank : 20)
Query Neighborhood Hits	158	Target Neighborhood Hits	172	Shared Neighborhood Hits	46
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_MOUSE
NC score	0.795386 (rank : 23)	θ value	2.19075e-38 (rank : 17)
Query Neighborhood Hits	158	Target Neighborhood Hits	278	Shared Neighborhood Hits	58
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.792173 (rank : 24)	θ value	1.98146e-39 (rank : 14)
Query Neighborhood Hits	158	Target Neighborhood Hits	303	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.790299 (rank : 25)	θ value	2.19075e-38 (rank : 18)
Query Neighborhood Hits	158	Target Neighborhood Hits	284	Shared Neighborhood Hits	56
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.788487 (rank : 26)	θ value	9.83387e-39 (rank : 15)
Query Neighborhood Hits	158	Target Neighborhood Hits	369	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

CNGB3_MOUSE
NC score	0.754483 (rank : 27)	θ value	2.87452e-22 (rank : 27)
Query Neighborhood Hits	158	Target Neighborhood Hits	74	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.739519 (rank : 28)	θ value	2.27762e-19 (rank : 28)
Query Neighborhood Hits	158	Target Neighborhood Hits	206	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.732789 (rank : 29)	θ value	5.60996e-18 (rank : 29)
Query Neighborhood Hits	158	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

KCNKH_HUMAN
NC score	0.247086 (rank : 30)	θ value	0.00298849 (rank : 30)
Query Neighborhood Hits	158	Target Neighborhood Hits	89	Shared Neighborhood Hits	46
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

KCNKF_HUMAN
NC score	0.188406 (rank : 31)	θ value	0.0113563 (rank : 33)
Query Neighborhood Hits	158	Target Neighborhood Hits	87	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.184076 (rank : 32)	θ value	0.0113563 (rank : 31)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
NC score	0.183439 (rank : 33)	θ value	0.0113563 (rank : 32)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
NC score	0.175650 (rank : 34)	θ value	0.0961366 (rank : 42)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNKA_HUMAN
NC score	0.174277 (rank : 35)	θ value	0.0736092 (rank : 38)
Query Neighborhood Hits	158	Target Neighborhood Hits	111	Shared Neighborhood Hits	46
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNK6_HUMAN
NC score	0.173704 (rank : 36)	θ value	0.0961366 (rank : 43)
Query Neighborhood Hits	158	Target Neighborhood Hits	79	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_MOUSE
NC score	0.171969 (rank : 37)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	158	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
NC score	0.163786 (rank : 38)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	158	Target Neighborhood Hits	109	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNKG_HUMAN
NC score	0.160715 (rank : 39)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	158	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KAP0_HUMAN
NC score	0.156355 (rank : 40)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	158	Target Neighborhood Hits	52	Shared Neighborhood Hits	32
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KCNK4_MOUSE
NC score	0.152788 (rank : 41)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	158	Target Neighborhood Hits	118	Shared Neighborhood Hits	50
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

KCNK9_MOUSE
NC score	0.147096 (rank : 42)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q3LS21	Gene names	Kcnk9, Task3
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3).

KCNK9_HUMAN
NC score	0.146953 (rank : 43)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	158	Target Neighborhood Hits	86	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NPC2, Q2M290, Q540F2	Gene names	KCNK9, TASK3
Domain Architecture
Description	Potassium channel subfamily K member 9 (Acid-sensitive potassium channel protein TASK-3) (TWIK-related acid-sensitive K(+) channel 3) (Two pore potassium channel KT3.2).

KAP0_MOUSE
NC score	0.144987 (rank : 44)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	158	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_HUMAN
NC score	0.131878 (rank : 45)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	30
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.129577 (rank : 46)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	158	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KCNK1_HUMAN
NC score	0.124842 (rank : 47)	θ value	1.81305 (rank : 82)
Query Neighborhood Hits	158	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O00180, Q13307	Gene names	KCNK1, HOHO1, KCNO1, TWIK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1).

KCNK5_HUMAN
NC score	0.123855 (rank : 48)	θ value	2.36792 (rank : 90)
Query Neighborhood Hits	158	Target Neighborhood Hits	102	Shared Neighborhood Hits	48
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

KCNK1_MOUSE
NC score	0.120183 (rank : 49)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	158	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O08581	Gene names	Kcnk1
Domain Architecture
Description	Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1).

KCNKD_MOUSE
NC score	0.101172 (rank : 50)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	158	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1P5	Gene names	Kcnk13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KAP3_MOUSE
NC score	0.092842 (rank : 51)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	158	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
NC score	0.092409 (rank : 52)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	158	Target Neighborhood Hits	44	Shared Neighborhood Hits	22
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.090259 (rank : 53)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	158	Target Neighborhood Hits	48	Shared Neighborhood Hits	22
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
NC score	0.089474 (rank : 54)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	158	Target Neighborhood Hits	40	Shared Neighborhood Hits	25
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KCNKD_HUMAN
NC score	0.080348 (rank : 55)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HB14, Q96E79	Gene names	KCNK13
Domain Architecture
Description	Potassium channel subfamily K member 13 (Tandem pore domain halothane- inhibited potassium channel 1) (THIK-1).

KCNKC_HUMAN
NC score	0.078281 (rank : 56)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	158	Target Neighborhood Hits	51	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB15	Gene names	KCNK12
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 12 (Tandem pore domain halothane- inhibited potassium channel 2) (THIK-2).

KCNK7_MOUSE
NC score	0.070812 (rank : 57)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	158	Target Neighborhood Hits	53	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

CT152_MOUSE
NC score	0.068259 (rank : 58)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	158	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KCND1_MOUSE
NC score	0.066273 (rank : 59)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	158	Target Neighborhood Hits	165	Shared Neighborhood Hits	46
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.060326 (rank : 60)	θ value	0.47712 (rank : 57)
Query Neighborhood Hits	158	Target Neighborhood Hits	160	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCMA1_MOUSE
NC score	0.060016 (rank : 61)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	158	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCMA1_HUMAN
NC score	0.059908 (rank : 62)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	158	Target Neighborhood Hits	96	Shared Neighborhood Hits	37
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCND2_HUMAN
NC score	0.058781 (rank : 63)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	158	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
NC score	0.058770 (rank : 64)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	158	Target Neighborhood Hits	156	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND3_MOUSE
NC score	0.055471 (rank : 65)	θ value	2.36792 (rank : 89)
Query Neighborhood Hits	158	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.055458 (rank : 66)	θ value	2.36792 (rank : 88)
Query Neighborhood Hits	158	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNQ3_MOUSE
NC score	0.055277 (rank : 67)	θ value	3.0926 (rank : 103)
Query Neighborhood Hits	158	Target Neighborhood Hits	105	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNK7_HUMAN
NC score	0.053513 (rank : 68)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	158	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y2U2, Q9Y2U3, Q9Y2U4	Gene names	KCNK7
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7.

KCNQ3_HUMAN
NC score	0.053144 (rank : 69)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	158	Target Neighborhood Hits	114	Shared Neighborhood Hits	40
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KGP1B_HUMAN
NC score	0.044627 (rank : 70)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	158	Target Neighborhood Hits	921	Shared Neighborhood Hits	44
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.044526 (rank : 71)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	158	Target Neighborhood Hits	901	Shared Neighborhood Hits	43
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_MOUSE
NC score	0.044174 (rank : 72)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	158	Target Neighborhood Hits	922	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

RPGF4_MOUSE
NC score	0.043619 (rank : 73)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	158	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

NRX2B_HUMAN
NC score	0.043157 (rank : 74)	θ value	0.163984 (rank : 46)
Query Neighborhood Hits	158	Target Neighborhood Hits	481	Shared Neighborhood Hits	18
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PSL1_HUMAN
NC score	0.041089 (rank : 75)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	158	Target Neighborhood Hits	650	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

KCNQ2_HUMAN
NC score	0.040954 (rank : 76)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	158	Target Neighborhood Hits	114	Shared Neighborhood Hits	42
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

OGFR_HUMAN
NC score	0.040324 (rank : 77)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	158	Target Neighborhood Hits	1582	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

KCNQ2_MOUSE
NC score	0.040031 (rank : 78)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

RPGF4_HUMAN
NC score	0.039529 (rank : 79)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	158	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

HSF1_MOUSE
NC score	0.037579 (rank : 80)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	158	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

RGS3_MOUSE
NC score	0.036713 (rank : 81)	θ value	0.365318 (rank : 55)
Query Neighborhood Hits	158	Target Neighborhood Hits	1621	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

HSF1_HUMAN
NC score	0.035228 (rank : 82)	θ value	0.0736092 (rank : 37)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

KCNN4_HUMAN
NC score	0.034334 (rank : 83)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	158	Target Neighborhood Hits	90	Shared Neighborhood Hits	36
SwissProt Accessions	O15554	Gene names	KCNN4, IK1, IKCA1, KCA4, SK4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1) (IKCa1) (Putative Gardos channel).

CA106_MOUSE
NC score	0.032919 (rank : 84)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	158	Target Neighborhood Hits	89	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

NACAM_MOUSE
NC score	0.032577 (rank : 85)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	158	Target Neighborhood Hits	1866	Shared Neighborhood Hits	54
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SF3B1_HUMAN
NC score	0.032224 (rank : 86)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	158	Target Neighborhood Hits	341	Shared Neighborhood Hits	18
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
NC score	0.032217 (rank : 87)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	158	Target Neighborhood Hits	352	Shared Neighborhood Hits	19
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

MAGE1_HUMAN
NC score	0.031591 (rank : 88)	θ value	1.81305 (rank : 83)
Query Neighborhood Hits	158	Target Neighborhood Hits	1389	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CEBPE_HUMAN
NC score	0.031570 (rank : 89)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	158	Target Neighborhood Hits	236	Shared Neighborhood Hits	15
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

KCNN4_MOUSE
NC score	0.030975 (rank : 90)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	158	Target Neighborhood Hits	85	Shared Neighborhood Hits	37
SwissProt Accessions	O89109, Q3U1J8, Q9CY39	Gene names	Kcnn4
Domain Architecture
Description	Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (KCa4) (IK1).

CP007_MOUSE
NC score	0.030492 (rank : 91)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	158	Target Neighborhood Hits	231	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

SRRM1_HUMAN
NC score	0.029905 (rank : 92)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	158	Target Neighborhood Hits	690	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

NRX2A_HUMAN
NC score	0.028925 (rank : 93)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	158	Target Neighborhood Hits	614	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

ATPD_HUMAN
NC score	0.027400 (rank : 94)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	158	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P30049	Gene names	ATP5D
Domain Architecture
Description	ATP synthase delta chain, mitochondrial precursor (EC 3.6.3.14).

RGS3_HUMAN
NC score	0.027393 (rank : 95)	θ value	1.38821 (rank : 80)
Query Neighborhood Hits	158	Target Neighborhood Hits	1375	Shared Neighborhood Hits	45
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

NCOA6_HUMAN
NC score	0.027363 (rank : 96)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	158	Target Neighborhood Hits	1202	Shared Neighborhood Hits	45
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SRRM1_MOUSE
NC score	0.026803 (rank : 97)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	158	Target Neighborhood Hits	966	Shared Neighborhood Hits	42
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

FRS3_MOUSE
NC score	0.026018 (rank : 98)	θ value	0.365318 (rank : 50)
Query Neighborhood Hits	158	Target Neighborhood Hits	168	Shared Neighborhood Hits	10
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

CEBPE_MOUSE
NC score	0.025920 (rank : 99)	θ value	0.21417 (rank : 47)
Query Neighborhood Hits	158	Target Neighborhood Hits	108	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PZD9	Gene names	Cebpe
Domain Architecture	No domain graphic available
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

NRG2_MOUSE
NC score	0.025312 (rank : 100)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	158	Target Neighborhood Hits	392	Shared Neighborhood Hits	6
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

TOPRS_MOUSE
NC score	0.024936 (rank : 101)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	158	Target Neighborhood Hits	263	Shared Neighborhood Hits	5
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

NRG2_HUMAN
NC score	0.024838 (rank : 102)	θ value	0.62314 (rank : 64)
Query Neighborhood Hits	158	Target Neighborhood Hits	419	Shared Neighborhood Hits	13
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

TAF4_HUMAN
NC score	0.024612 (rank : 103)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	158	Target Neighborhood Hits	687	Shared Neighborhood Hits	30
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

FRS3_HUMAN
NC score	0.022513 (rank : 104)	θ value	1.06291 (rank : 73)
Query Neighborhood Hits	158	Target Neighborhood Hits	76	Shared Neighborhood Hits	5
SwissProt Accessions	O43559, Q5T3D5	Gene names	FRS3
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (Suc1-associated neurotrophic factor target 2) (SNT-2) (FGFR signaling adaptor SNT2).

SNPC4_HUMAN
NC score	0.022432 (rank : 105)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	158	Target Neighborhood Hits	589	Shared Neighborhood Hits	27
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

LYSM2_HUMAN
NC score	0.021117 (rank : 106)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	158	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV50, Q5CZ88, Q8WTV3	Gene names	LYSMD2
Domain Architecture	No domain graphic available
Description	LysM and putative peptidoglycan-binding domain-containing protein 2.

PDZD2_HUMAN
NC score	0.020482 (rank : 107)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	158	Target Neighborhood Hits	772	Shared Neighborhood Hits	30
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

NFH_MOUSE
NC score	0.019791 (rank : 108)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	158	Target Neighborhood Hits	2247	Shared Neighborhood Hits	55
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CI150_MOUSE
NC score	0.019266 (rank : 109)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2P1, Q9D150	Gene names	D4Bwg0951e
Domain Architecture	No domain graphic available
Description	Protein C9orf150 homolog.

SCN7A_HUMAN
NC score	0.018011 (rank : 110)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	158	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

FOXN1_HUMAN
NC score	0.017259 (rank : 111)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	158	Target Neighborhood Hits	377	Shared Neighborhood Hits	22
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

REL1_MOUSE
NC score	0.015642 (rank : 112)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	158	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P47932	Gene names	Rln1, Rln, Rlx
Domain Architecture
Description	Prorelaxin 1 precursor [Contains: Relaxin B chain; Relaxin A chain].

TOPRS_HUMAN
NC score	0.015506 (rank : 113)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	158	Target Neighborhood Hits	286	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

VASP_MOUSE
NC score	0.015468 (rank : 114)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	158	Target Neighborhood Hits	195	Shared Neighborhood Hits	17
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

EMSY_MOUSE
NC score	0.014944 (rank : 115)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	158	Target Neighborhood Hits	294	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

TSSC4_HUMAN
NC score	0.014807 (rank : 116)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	158	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y5U2, Q86VL2, Q9BRS6	Gene names	TSSC4
Domain Architecture	No domain graphic available
Description	Protein TSSC4 (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein) (Tumor-suppressing STF cDNA 4 protein).

AFF1_MOUSE
NC score	0.014401 (rank : 117)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	158	Target Neighborhood Hits	351	Shared Neighborhood Hits	20
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

ZP1_MOUSE
NC score	0.014278 (rank : 118)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	158	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q62005, Q62016	Gene names	Zp1
Domain Architecture
Description	Zona pellucida sperm-binding protein 1 precursor (Zona pellucida glycoprotein 1) (Zp-1).

RGS14_HUMAN
NC score	0.014110 (rank : 119)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	158	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	O43566, O43565, Q8TD62	Gene names	RGS14
Domain Architecture
Description	Regulator of G-protein signaling 14 (RGS14).

MNAB_HUMAN
NC score	0.013768 (rank : 120)	θ value	1.81305 (rank : 84)
Query Neighborhood Hits	158	Target Neighborhood Hits	196	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

RERE_MOUSE
NC score	0.013620 (rank : 121)	θ value	1.81305 (rank : 85)
Query Neighborhood Hits	158	Target Neighborhood Hits	785	Shared Neighborhood Hits	34
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

CN004_HUMAN
NC score	0.013326 (rank : 122)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	158	Target Neighborhood Hits	108	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H1B7, Q8NDQ2, Q96JG2, Q9H3I7	Gene names	C14orf4, KIAA1865
Domain Architecture	No domain graphic available
Description	Protein C14orf4.

ENAH_MOUSE
NC score	0.012646 (rank : 123)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	158	Target Neighborhood Hits	919	Shared Neighborhood Hits	31
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

RP1L1_MOUSE
NC score	0.012349 (rank : 124)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	158	Target Neighborhood Hits	170	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

ABD12_HUMAN
NC score	0.011697 (rank : 125)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N2K0, Q5T710, Q96CR1, Q9BX05, Q9NPX7, Q9UFV6	Gene names	Abhd12, C20orf22
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

ABD12_MOUSE
NC score	0.011691 (rank : 126)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	158	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q99LR1, Q99M06	Gene names	Abhd12
Domain Architecture
Description	Abhydrolase domain-containing protein 12.

CN004_MOUSE
NC score	0.011628 (rank : 127)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	158	Target Neighborhood Hits	105	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3X4, Q3USE5, Q8BUS1, Q8C011	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf4 homolog.

ATG9A_HUMAN
NC score	0.011296 (rank : 128)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	158	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z3C6, Q6P0N7, Q7Z317, Q7Z320, Q8NDK6, Q8WU65, Q9BVL5, Q9H6L1, Q9HAG7	Gene names	ATG9A, APG9L1
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 9A (APG9-like 1).

AF17_HUMAN
NC score	0.011179 (rank : 129)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	158	Target Neighborhood Hits	230	Shared Neighborhood Hits	13
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

3BHS7_MOUSE
NC score	0.011101 (rank : 130)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	158	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQC1	Gene names	Hsd3b7
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 7 (3 beta-hydroxysteroid dehydrogenase type VII) (3Beta-HSD VII) (3-beta-hydroxy-delta(5)-C27 steroid oxidoreductase) (EC 1.1.1.-) (C(27) 3beta-HSD).

CQ10A_HUMAN
NC score	0.011010 (rank : 131)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	158	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q96MF6, Q6GMR6, Q6UWB9, Q86X16, Q96MF1, Q9BUP4	Gene names	COQ10A
Domain Architecture	No domain graphic available
Description	Protein COQ10 A, mitochondrial precursor.

IRS2_HUMAN
NC score	0.010324 (rank : 132)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	158	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

NCA11_MOUSE
NC score	0.010187 (rank : 133)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	158	Target Neighborhood Hits	661	Shared Neighborhood Hits	20
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ZN516_MOUSE
NC score	0.009483 (rank : 134)	θ value	0.0563607 (rank : 35)
Query Neighborhood Hits	158	Target Neighborhood Hits	1197	Shared Neighborhood Hits	30
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CUTL2_HUMAN
NC score	0.009421 (rank : 135)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	158	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

PKP3_HUMAN
NC score	0.008671 (rank : 136)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	158	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y446	Gene names	PKP3
Domain Architecture
Description	Plakophilin-3.

CC054_HUMAN
NC score	0.007833 (rank : 137)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	158	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q96EL1	Gene names	C3orf54
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf54.

SOCS7_MOUSE
NC score	0.007756 (rank : 138)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	158	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

TASP1_MOUSE
NC score	0.007546 (rank : 139)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	158	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1G1, Q99JP3	Gene names	Tasp1
Domain Architecture
Description	Threonine aspartase 1 (EC 3.4.25.-) (Taspase-1) [Contains: Threonine aspartase subunit alpha; Threonine aspartase subunit beta].

XYLT1_HUMAN
NC score	0.007499 (rank : 140)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	158	Target Neighborhood Hits	87	Shared Neighborhood Hits	6
SwissProt Accessions	Q86Y38, Q9H1B6	Gene names	XYLT1, XT1
Domain Architecture	No domain graphic available
Description	Xylosyltransferase 1 (EC 2.4.2.26) (Xylosyltransferase I) (XylT-I) (XT-I) (Peptide O-xylosyltransferase 1).

GP124_MOUSE
NC score	0.007452 (rank : 141)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	158	Target Neighborhood Hits	423	Shared Neighborhood Hits	6
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

SEZ6L_HUMAN
NC score	0.006568 (rank : 142)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	158	Target Neighborhood Hits	289	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

FOG1_MOUSE
NC score	0.006144 (rank : 143)	θ value	1.06291 (rank : 72)
Query Neighborhood Hits	158	Target Neighborhood Hits	1237	Shared Neighborhood Hits	37
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

MY18B_HUMAN
NC score	0.005168 (rank : 144)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	158	Target Neighborhood Hits	1299	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MAST4_HUMAN
NC score	0.004967 (rank : 145)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	158	Target Neighborhood Hits	1804	Shared Neighborhood Hits	43
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

TOM40_HUMAN
NC score	0.004862 (rank : 146)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	158	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	O96008, Q86VW4, Q8WY09, Q8WY10, Q8WY11, Q9BR95	Gene names	TOMM40, PEREC1, TOM40
Domain Architecture
Description	Probable mitochondrial import receptor subunit TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5).

SVIL_MOUSE
NC score	0.004758 (rank : 147)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	158	Target Neighborhood Hits	439	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

RECQ4_HUMAN
NC score	0.004601 (rank : 148)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	158	Target Neighborhood Hits	177	Shared Neighborhood Hits	10
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

ANR25_HUMAN
NC score	0.004583 (rank : 149)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	158	Target Neighborhood Hits	350	Shared Neighborhood Hits	11
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

TIF1G_MOUSE
NC score	0.004475 (rank : 150)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	158	Target Neighborhood Hits	498	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TGIF_HUMAN
NC score	0.004251 (rank : 151)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	158	Target Neighborhood Hits	109	Shared Neighborhood Hits	3
SwissProt Accessions	Q15583, Q6ICR0, Q8N5X9, Q9NRS0	Gene names	TGIF
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

MTMR3_HUMAN
NC score	0.004243 (rank : 152)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	158	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

TBCD1_MOUSE
NC score	0.003637 (rank : 153)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	158	Target Neighborhood Hits	241	Shared Neighborhood Hits	4
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

LDB3_HUMAN
NC score	0.003270 (rank : 154)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	158	Target Neighborhood Hits	497	Shared Neighborhood Hits	20
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

TIF1G_HUMAN
NC score	0.003141 (rank : 155)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	158	Target Neighborhood Hits	410	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

PITM1_MOUSE
NC score	0.003002 (rank : 156)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	158	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

MEFV_HUMAN
NC score	0.001896 (rank : 157)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	158	Target Neighborhood Hits	431	Shared Neighborhood Hits	12
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MAST1_MOUSE
NC score	0.001724 (rank : 158)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	158	Target Neighborhood Hits	1123	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

HXB5_HUMAN
NC score	-0.000423 (rank : 159)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	158	Target Neighborhood Hits	332	Shared Neighborhood Hits	4
SwissProt Accessions	P09067, P09069	Gene names	HOXB5, HOX2A
Domain Architecture
Description	Homeobox protein Hox-B5 (Hox-2A) (HHO.C10) (HU-1).

GLI1_HUMAN
NC score	-0.000953 (rank : 160)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	158	Target Neighborhood Hits	828	Shared Neighborhood Hits	13
SwissProt Accessions	P08151, Q8TDN9	Gene names	GLI1, GLI
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI).

MARK2_HUMAN
NC score	-0.000957 (rank : 161)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	158	Target Neighborhood Hits	1056	Shared Neighborhood Hits	22
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

DCAK2_MOUSE
NC score	-0.002051 (rank : 162)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	158	Target Neighborhood Hits	858	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

M3K10_HUMAN
NC score	-0.002484 (rank : 163)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	158	Target Neighborhood Hits	1071	Shared Neighborhood Hits	15
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

ZNF31_HUMAN
NC score	-0.003036 (rank : 164)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	158	Target Neighborhood Hits	769	Shared Neighborhood Hits	7
SwissProt Accessions	P17040, Q96H84	Gene names	ZNF31, KOX29, ZNF360, ZSCAN20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 31 (Zinc finger protein KOX29) (Zinc finger and SCAN domain-containing protein 20) (Zinc finger protein 360).

ZBT16_HUMAN
NC score	-0.003559 (rank : 165)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	158	Target Neighborhood Hits	1010	Shared Neighborhood Hits	10
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).