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Network neighborhood for query Sequence : CNGA3_HUMAN

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CNGA3_HUMAN
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CNGA1_HUMAN
θ value	0 (rank : 1)	NC score	0.987430 (rank : 4)
Query Neighborhood Hits	125	Target Neighborhood Hits	149	Shared Neighborhood Hits	60
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	0 (rank : 2)	NC score	0.984106 (rank : 5)
Query Neighborhood Hits	125	Target Neighborhood Hits	198	Shared Neighborhood Hits	67
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	0 (rank : 3)	NC score	0.990035 (rank : 3)
Query Neighborhood Hits	125	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	125	Target Neighborhood Hits	125	Shared Neighborhood Hits	125
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
θ value	0 (rank : 5)	NC score	0.995200 (rank : 2)
Query Neighborhood Hits	125	Target Neighborhood Hits	84	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGB3_HUMAN
θ value	1.35638e-80 (rank : 6)	NC score	0.929543 (rank : 7)
Query Neighborhood Hits	125	Target Neighborhood Hits	206	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
θ value	2.64714e-76 (rank : 7)	NC score	0.926409 (rank : 8)
Query Neighborhood Hits	125	Target Neighborhood Hits	222	Shared Neighborhood Hits	49
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
θ value	1.15091e-71 (rank : 8)	NC score	0.941061 (rank : 6)
Query Neighborhood Hits	125	Target Neighborhood Hits	74	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

HCN4_HUMAN
θ value	9.50281e-42 (rank : 9)	NC score	0.834924 (rank : 14)
Query Neighborhood Hits	125	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN1_HUMAN
θ value	1.79215e-40 (rank : 10)	NC score	0.854856 (rank : 9)
Query Neighborhood Hits	125	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	1.79215e-40 (rank : 11)	NC score	0.851416 (rank : 11)
Query Neighborhood Hits	125	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN4_MOUSE
θ value	3.99248e-40 (rank : 12)	NC score	0.833124 (rank : 15)
Query Neighborhood Hits	125	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN3_HUMAN
θ value	8.89434e-40 (rank : 13)	NC score	0.851140 (rank : 12)
Query Neighborhood Hits	125	Target Neighborhood Hits	99	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
θ value	8.89434e-40 (rank : 14)	NC score	0.851918 (rank : 10)
Query Neighborhood Hits	125	Target Neighborhood Hits	112	Shared Neighborhood Hits	41
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN2_MOUSE
θ value	1.16164e-39 (rank : 15)	NC score	0.838028 (rank : 13)
Query Neighborhood Hits	125	Target Neighborhood Hits	278	Shared Neighborhood Hits	43
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN2_HUMAN
θ value	9.83387e-39 (rank : 16)	NC score	0.827722 (rank : 16)
Query Neighborhood Hits	125	Target Neighborhood Hits	369	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

KCNH2_HUMAN
θ value	2.67802e-36 (rank : 17)	NC score	0.808740 (rank : 18)
Query Neighborhood Hits	125	Target Neighborhood Hits	158	Shared Neighborhood Hits	39
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	2.67802e-36 (rank : 18)	NC score	0.808631 (rank : 19)
Query Neighborhood Hits	125	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH7_MOUSE
θ value	1.24399e-33 (rank : 19)	NC score	0.809297 (rank : 17)
Query Neighborhood Hits	125	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH6_HUMAN
θ value	1.6247e-33 (rank : 20)	NC score	0.808593 (rank : 20)
Query Neighborhood Hits	125	Target Neighborhood Hits	222	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH4_HUMAN
θ value	6.17384e-33 (rank : 21)	NC score	0.804260 (rank : 21)
Query Neighborhood Hits	125	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH8_HUMAN
θ value	8.06329e-33 (rank : 22)	NC score	0.802989 (rank : 23)
Query Neighborhood Hits	125	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH3_HUMAN
θ value	8.91499e-32 (rank : 23)	NC score	0.793382 (rank : 24)
Query Neighborhood Hits	125	Target Neighborhood Hits	148	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH7_HUMAN
θ value	2.19584e-30 (rank : 24)	NC score	0.804196 (rank : 22)
Query Neighborhood Hits	125	Target Neighborhood Hits	107	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH3_MOUSE
θ value	3.17079e-29 (rank : 25)	NC score	0.793261 (rank : 25)
Query Neighborhood Hits	125	Target Neighborhood Hits	133	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH1_HUMAN
θ value	7.80994e-28 (rank : 26)	NC score	0.789552 (rank : 29)
Query Neighborhood Hits	125	Target Neighborhood Hits	98	Shared Neighborhood Hits	37
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	7.80994e-28 (rank : 27)	NC score	0.789882 (rank : 28)
Query Neighborhood Hits	125	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH5_HUMAN
θ value	3.28125e-26 (rank : 28)	NC score	0.792898 (rank : 27)
Query Neighborhood Hits	125	Target Neighborhood Hits	99	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	3.28125e-26 (rank : 29)	NC score	0.793150 (rank : 26)
Query Neighborhood Hits	125	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KGP1B_MOUSE
θ value	0.00035302 (rank : 30)	NC score	0.071461 (rank : 41)
Query Neighborhood Hits	125	Target Neighborhood Hits	922	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
θ value	0.000461057 (rank : 31)	NC score	0.070974 (rank : 43)
Query Neighborhood Hits	125	Target Neighborhood Hits	901	Shared Neighborhood Hits	47
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.000461057 (rank : 32)	NC score	0.071238 (rank : 42)
Query Neighborhood Hits	125	Target Neighborhood Hits	921	Shared Neighborhood Hits	49
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	0.00134147 (rank : 33)	NC score	0.069377 (rank : 45)
Query Neighborhood Hits	125	Target Neighborhood Hits	1023	Shared Neighborhood Hits	63
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	0.00134147 (rank : 34)	NC score	0.069147 (rank : 46)
Query Neighborhood Hits	125	Target Neighborhood Hits	1029	Shared Neighborhood Hits	66
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP1_HUMAN
θ value	0.00298849 (rank : 35)	NC score	0.238977 (rank : 31)
Query Neighborhood Hits	125	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
θ value	0.00665767 (rank : 36)	NC score	0.233556 (rank : 33)
Query Neighborhood Hits	125	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

SMC4_HUMAN
θ value	0.0193708 (rank : 37)	NC score	0.063966 (rank : 52)
Query Neighborhood Hits	125	Target Neighborhood Hits	937	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

KAP0_HUMAN
θ value	0.0252991 (rank : 38)	NC score	0.254312 (rank : 30)
Query Neighborhood Hits	125	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

SMC4_MOUSE
θ value	0.0252991 (rank : 39)	NC score	0.070248 (rank : 44)
Query Neighborhood Hits	125	Target Neighborhood Hits	830	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

KAP0_MOUSE
θ value	0.0330416 (rank : 40)	NC score	0.237319 (rank : 32)
Query Neighborhood Hits	125	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

MYH3_HUMAN
θ value	0.0431538 (rank : 41)	NC score	0.042851 (rank : 63)
Query Neighborhood Hits	125	Target Neighborhood Hits	1660	Shared Neighborhood Hits	73
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

JIP4_HUMAN
θ value	0.0736092 (rank : 42)	NC score	0.042660 (rank : 64)
Query Neighborhood Hits	125	Target Neighborhood Hits	585	Shared Neighborhood Hits	52
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

KAP3_MOUSE
θ value	0.0736092 (rank : 43)	NC score	0.199176 (rank : 34)
Query Neighborhood Hits	125	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

HMMR_MOUSE
θ value	0.163984 (rank : 44)	NC score	0.044250 (rank : 62)
Query Neighborhood Hits	125	Target Neighborhood Hits	1178	Shared Neighborhood Hits	68
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

JIP4_MOUSE
θ value	0.163984 (rank : 45)	NC score	0.039886 (rank : 80)
Query Neighborhood Hits	125	Target Neighborhood Hits	593	Shared Neighborhood Hits	51
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

KAP3_HUMAN
θ value	0.163984 (rank : 46)	NC score	0.193156 (rank : 35)
Query Neighborhood Hits	125	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

TPR_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.035984 (rank : 89)
Query Neighborhood Hits	125	Target Neighborhood Hits	1921	Shared Neighborhood Hits	75
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CROCC_HUMAN
θ value	0.365318 (rank : 48)	NC score	0.036437 (rank : 85)
Query Neighborhood Hits	125	Target Neighborhood Hits	1409	Shared Neighborhood Hits	69
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

GOGA3_HUMAN
θ value	0.365318 (rank : 49)	NC score	0.037834 (rank : 83)
Query Neighborhood Hits	125	Target Neighborhood Hits	1317	Shared Neighborhood Hits	70
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MYH10_HUMAN
θ value	0.47712 (rank : 50)	NC score	0.040586 (rank : 77)
Query Neighborhood Hits	125	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MAP1A_HUMAN
θ value	0.62314 (rank : 51)	NC score	0.045946 (rank : 61)
Query Neighborhood Hits	125	Target Neighborhood Hits	1626	Shared Neighborhood Hits	69
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MYH11_HUMAN
θ value	0.62314 (rank : 52)	NC score	0.038502 (rank : 82)
Query Neighborhood Hits	125	Target Neighborhood Hits	1806	Shared Neighborhood Hits	69
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.038784 (rank : 81)
Query Neighborhood Hits	125	Target Neighborhood Hits	1777	Shared Neighborhood Hits	70
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

X3CL1_MOUSE
θ value	0.813845 (rank : 54)	NC score	0.018740 (rank : 126)
Query Neighborhood Hits	125	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	O35188, O35933	Gene names	Cx3cl1, Cx3c, Fkn, Scyd1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

CENPE_HUMAN
θ value	1.06291 (rank : 55)	NC score	0.029220 (rank : 113)
Query Neighborhood Hits	125	Target Neighborhood Hits	2060	Shared Neighborhood Hits	72
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CT152_HUMAN
θ value	1.06291 (rank : 56)	NC score	0.119001 (rank : 39)
Query Neighborhood Hits	125	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

GOGB1_HUMAN
θ value	1.06291 (rank : 57)	NC score	0.035990 (rank : 88)
Query Neighborhood Hits	125	Target Neighborhood Hits	2297	Shared Neighborhood Hits	76
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

MYH10_MOUSE
θ value	1.06291 (rank : 58)	NC score	0.039901 (rank : 79)
Query Neighborhood Hits	125	Target Neighborhood Hits	1612	Shared Neighborhood Hits	69
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CT152_MOUSE
θ value	1.38821 (rank : 59)	NC score	0.153239 (rank : 38)
Query Neighborhood Hits	125	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

MY18A_HUMAN
θ value	1.38821 (rank : 60)	NC score	0.036861 (rank : 84)
Query Neighborhood Hits	125	Target Neighborhood Hits	1929	Shared Neighborhood Hits	72
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CASP_HUMAN
θ value	1.81305 (rank : 61)	NC score	0.034529 (rank : 95)
Query Neighborhood Hits	125	Target Neighborhood Hits	1131	Shared Neighborhood Hits	65
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.029285 (rank : 112)
Query Neighborhood Hits	125	Target Neighborhood Hits	1574	Shared Neighborhood Hits	65
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

EEA1_HUMAN
θ value	1.81305 (rank : 63)	NC score	0.031856 (rank : 103)
Query Neighborhood Hits	125	Target Neighborhood Hits	1796	Shared Neighborhood Hits	73
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

FYCO1_MOUSE
θ value	1.81305 (rank : 64)	NC score	0.035820 (rank : 91)
Query Neighborhood Hits	125	Target Neighborhood Hits	1059	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

MYH6_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.041619 (rank : 71)
Query Neighborhood Hits	125	Target Neighborhood Hits	1426	Shared Neighborhood Hits	71
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SYCP1_MOUSE
θ value	1.81305 (rank : 66)	NC score	0.034805 (rank : 94)
Query Neighborhood Hits	125	Target Neighborhood Hits	1456	Shared Neighborhood Hits	71
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CASP_MOUSE
θ value	2.36792 (rank : 67)	NC score	0.033925 (rank : 98)
Query Neighborhood Hits	125	Target Neighborhood Hits	1152	Shared Neighborhood Hits	67
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

KIFC3_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.019913 (rank : 124)
Query Neighborhood Hits	125	Target Neighborhood Hits	619	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KLDC4_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.011804 (rank : 129)
Query Neighborhood Hits	125	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

LIPA3_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.030215 (rank : 111)
Query Neighborhood Hits	125	Target Neighborhood Hits	636	Shared Neighborhood Hits	56
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

MYH1_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.041438 (rank : 74)
Query Neighborhood Hits	125	Target Neighborhood Hits	1478	Shared Neighborhood Hits	72
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.042342 (rank : 66)
Query Neighborhood Hits	125	Target Neighborhood Hits	1461	Shared Neighborhood Hits	73
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH2_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.041524 (rank : 72)
Query Neighborhood Hits	125	Target Neighborhood Hits	1491	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH4_HUMAN
θ value	2.36792 (rank : 74)	NC score	0.041016 (rank : 76)
Query Neighborhood Hits	125	Target Neighborhood Hits	1377	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH6_MOUSE
θ value	2.36792 (rank : 75)	NC score	0.041458 (rank : 73)
Query Neighborhood Hits	125	Target Neighborhood Hits	1501	Shared Neighborhood Hits	72
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

REST_MOUSE
θ value	2.36792 (rank : 76)	NC score	0.031562 (rank : 105)
Query Neighborhood Hits	125	Target Neighborhood Hits	1506	Shared Neighborhood Hits	69
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RPGF3_HUMAN
θ value	2.36792 (rank : 77)	NC score	0.056207 (rank : 58)
Query Neighborhood Hits	125	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

WDR47_HUMAN
θ value	2.36792 (rank : 78)	NC score	0.013878 (rank : 128)
Query Neighborhood Hits	125	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

EZRI_MOUSE
θ value	3.0926 (rank : 79)	NC score	0.021071 (rank : 121)
Query Neighborhood Hits	125	Target Neighborhood Hits	693	Shared Neighborhood Hits	56
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

KCNQ3_HUMAN
θ value	3.0926 (rank : 80)	NC score	0.034334 (rank : 97)
Query Neighborhood Hits	125	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.034847 (rank : 93)
Query Neighborhood Hits	125	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

LIPA2_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.033104 (rank : 100)
Query Neighborhood Hits	125	Target Neighborhood Hits	1044	Shared Neighborhood Hits	66
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

MYH4_MOUSE
θ value	3.0926 (rank : 83)	NC score	0.042329 (rank : 67)
Query Neighborhood Hits	125	Target Neighborhood Hits	1476	Shared Neighborhood Hits	72
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH7_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.042176 (rank : 69)
Query Neighborhood Hits	125	Target Neighborhood Hits	1559	Shared Neighborhood Hits	73
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH8_HUMAN
θ value	3.0926 (rank : 85)	NC score	0.041095 (rank : 75)
Query Neighborhood Hits	125	Target Neighborhood Hits	1610	Shared Neighborhood Hits	72
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	3.0926 (rank : 86)	NC score	0.040056 (rank : 78)
Query Neighborhood Hits	125	Target Neighborhood Hits	1600	Shared Neighborhood Hits	71
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH9_MOUSE
θ value	3.0926 (rank : 87)	NC score	0.041620 (rank : 70)
Query Neighborhood Hits	125	Target Neighborhood Hits	1829	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NUMA1_HUMAN
θ value	3.0926 (rank : 88)	NC score	0.031209 (rank : 106)
Query Neighborhood Hits	125	Target Neighborhood Hits	1523	Shared Neighborhood Hits	66
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RPGF3_MOUSE
θ value	3.0926 (rank : 89)	NC score	0.062631 (rank : 55)
Query Neighborhood Hits	125	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RRBP1_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.031148 (rank : 107)
Query Neighborhood Hits	125	Target Neighborhood Hits	1306	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RRBP1_MOUSE
θ value	3.0926 (rank : 91)	NC score	0.030636 (rank : 110)
Query Neighborhood Hits	125	Target Neighborhood Hits	1650	Shared Neighborhood Hits	70
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

TPM2_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.034339 (rank : 96)
Query Neighborhood Hits	125	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

WRN_MOUSE
θ value	3.0926 (rank : 93)	NC score	0.007949 (rank : 132)
Query Neighborhood Hits	125	Target Neighborhood Hits	295	Shared Neighborhood Hits	16
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

EZRI_HUMAN
θ value	4.03905 (rank : 94)	NC score	0.020655 (rank : 123)
Query Neighborhood Hits	125	Target Neighborhood Hits	663	Shared Neighborhood Hits	56
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

LIPA2_MOUSE
θ value	4.03905 (rank : 95)	NC score	0.031732 (rank : 104)
Query Neighborhood Hits	125	Target Neighborhood Hits	1282	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

MY18A_MOUSE
θ value	4.03905 (rank : 96)	NC score	0.035981 (rank : 90)
Query Neighborhood Hits	125	Target Neighborhood Hits	1989	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

AKAP9_HUMAN
θ value	5.27518 (rank : 97)	NC score	0.032689 (rank : 101)
Query Neighborhood Hits	125	Target Neighborhood Hits	1710	Shared Neighborhood Hits	72
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BCN1_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.024339 (rank : 119)
Query Neighborhood Hits	125	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

CGRE1_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.028854 (rank : 114)
Query Neighborhood Hits	125	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

GOGA3_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.036164 (rank : 86)
Query Neighborhood Hits	125	Target Neighborhood Hits	1437	Shared Neighborhood Hits	70
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

KCNK5_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.042438 (rank : 65)
Query Neighborhood Hits	125	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

LIPA1_HUMAN
θ value	5.27518 (rank : 102)	NC score	0.030737 (rank : 109)
Query Neighborhood Hits	125	Target Neighborhood Hits	1294	Shared Neighborhood Hits	67
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

RADI_HUMAN
θ value	5.27518 (rank : 103)	NC score	0.020932 (rank : 122)
Query Neighborhood Hits	125	Target Neighborhood Hits	741	Shared Neighborhood Hits	57
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

SIL1_MOUSE
θ value	5.27518 (rank : 104)	NC score	0.014706 (rank : 127)
Query Neighborhood Hits	125	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EPK6, Q91V34	Gene names	Sil1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor.

UACA_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.027173 (rank : 118)
Query Neighborhood Hits	125	Target Neighborhood Hits	1622	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

UACA_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.027724 (rank : 116)
Query Neighborhood Hits	125	Target Neighborhood Hits	1620	Shared Neighborhood Hits	67
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ANR11_HUMAN
θ value	6.88961 (rank : 107)	NC score	0.010667 (rank : 130)
Query Neighborhood Hits	125	Target Neighborhood Hits	1289	Shared Neighborhood Hits	47
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

HOOK1_HUMAN
θ value	6.88961 (rank : 108)	NC score	0.031912 (rank : 102)
Query Neighborhood Hits	125	Target Neighborhood Hits	942	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

HOOK1_MOUSE
θ value	6.88961 (rank : 109)	NC score	0.027571 (rank : 117)
Query Neighborhood Hits	125	Target Neighborhood Hits	910	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MPP9_HUMAN
θ value	6.88961 (rank : 110)	NC score	0.033723 (rank : 99)
Query Neighborhood Hits	125	Target Neighborhood Hits	529	Shared Neighborhood Hits	57
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

TRFR_HUMAN
θ value	6.88961 (rank : 111)	NC score	-0.003875 (rank : 139)
Query Neighborhood Hits	125	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	P34981	Gene names	TRHR
Domain Architecture
Description	Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor).

AP4S1_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.003964 (rank : 136)
Query Neighborhood Hits	125	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

CCD93_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.028433 (rank : 115)
Query Neighborhood Hits	125	Target Neighborhood Hits	600	Shared Neighborhood Hits	60
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CES3_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.001802 (rank : 137)
Query Neighborhood Hits	125	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

HAX1_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.007622 (rank : 133)
Query Neighborhood Hits	125	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O00165, Q96AU4, Q9BS80	Gene names	HAX1, HS1BP1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

K1C20_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.010409 (rank : 131)
Query Neighborhood Hits	125	Target Neighborhood Hits	468	Shared Neighborhood Hits	49
SwissProt Accessions	P35900	Gene names	KRT20
Domain Architecture
Description	Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT).

KIFC3_MOUSE
θ value	8.99809 (rank : 117)	NC score	0.019002 (rank : 125)
Query Neighborhood Hits	125	Target Neighborhood Hits	571	Shared Neighborhood Hits	61
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

MYH14_MOUSE
θ value	8.99809 (rank : 118)	NC score	0.042218 (rank : 68)
Query Neighborhood Hits	125	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYO5A_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.036156 (rank : 87)
Query Neighborhood Hits	125	Target Neighborhood Hits	1117	Shared Neighborhood Hits	67
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

PK3CB_MOUSE
θ value	8.99809 (rank : 120)	NC score	0.007019 (rank : 135)
Query Neighborhood Hits	125	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PLEC1_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.022382 (rank : 120)
Query Neighborhood Hits	125	Target Neighborhood Hits	1326	Shared Neighborhood Hits	61
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

TEP1_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.000370 (rank : 138)
Query Neighborhood Hits	125	Target Neighborhood Hits	344	Shared Neighborhood Hits	3
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

TNIK_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.007156 (rank : 134)
Query Neighborhood Hits	125	Target Neighborhood Hits	1570	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TPM2_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.031107 (rank : 108)
Query Neighborhood Hits	125	Target Neighborhood Hits	677	Shared Neighborhood Hits	60
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM3_MOUSE
θ value	8.99809 (rank : 125)	NC score	0.035447 (rank : 92)
Query Neighborhood Hits	125	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

KAP2_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.180963 (rank : 37)
Query Neighborhood Hits	125	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.184205 (rank : 36)
Query Neighborhood Hits	125	Target Neighborhood Hits	44	Shared Neighborhood Hits	28
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KCNK2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.065804 (rank : 48)
Query Neighborhood Hits	125	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.065396 (rank : 50)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.063266 (rank : 53)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.061388 (rank : 57)
Query Neighborhood Hits	125	Target Neighborhood Hits	93	Shared Neighborhood Hits	16
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.055875 (rank : 59)
Query Neighborhood Hits	125	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNK6_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.063989 (rank : 51)
Query Neighborhood Hits	125	Target Neighborhood Hits	79	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNKA_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.061528 (rank : 56)
Query Neighborhood Hits	125	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNKF_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.067998 (rank : 47)
Query Neighborhood Hits	125	Target Neighborhood Hits	87	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNKG_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.054036 (rank : 60)
Query Neighborhood Hits	125	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KCNKH_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.101937 (rank : 40)
Query Neighborhood Hits	125	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

RPGF4_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.062992 (rank : 54)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.065722 (rank : 49)
Query Neighborhood Hits	125	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

Hits sorted by NC score

CNGA3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	125	Target Neighborhood Hits	125	Shared Neighborhood Hits	125
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
NC score	0.995200 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	125	Target Neighborhood Hits	84	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
NC score	0.990035 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	125	Target Neighborhood Hits	86	Shared Neighborhood Hits	57
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_HUMAN
NC score	0.987430 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	125	Target Neighborhood Hits	149	Shared Neighborhood Hits	60
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.984106 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	125	Target Neighborhood Hits	198	Shared Neighborhood Hits	67
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGB3_MOUSE
NC score	0.941061 (rank : 6)	θ value	1.15091e-71 (rank : 8)
Query Neighborhood Hits	125	Target Neighborhood Hits	74	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.929543 (rank : 7)	θ value	1.35638e-80 (rank : 6)
Query Neighborhood Hits	125	Target Neighborhood Hits	206	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.926409 (rank : 8)	θ value	2.64714e-76 (rank : 7)
Query Neighborhood Hits	125	Target Neighborhood Hits	222	Shared Neighborhood Hits	49
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

HCN1_HUMAN
NC score	0.854856 (rank : 9)	θ value	1.79215e-40 (rank : 10)
Query Neighborhood Hits	125	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN3_MOUSE
NC score	0.851918 (rank : 10)	θ value	8.89434e-40 (rank : 14)
Query Neighborhood Hits	125	Target Neighborhood Hits	112	Shared Neighborhood Hits	41
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN1_MOUSE
NC score	0.851416 (rank : 11)	θ value	1.79215e-40 (rank : 11)
Query Neighborhood Hits	125	Target Neighborhood Hits	172	Shared Neighborhood Hits	51
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_HUMAN
NC score	0.851140 (rank : 12)	θ value	8.89434e-40 (rank : 13)
Query Neighborhood Hits	125	Target Neighborhood Hits	99	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN2_MOUSE
NC score	0.838028 (rank : 13)	θ value	1.16164e-39 (rank : 15)
Query Neighborhood Hits	125	Target Neighborhood Hits	278	Shared Neighborhood Hits	43
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.834924 (rank : 14)	θ value	9.50281e-42 (rank : 9)
Query Neighborhood Hits	125	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.833124 (rank : 15)	θ value	3.99248e-40 (rank : 12)
Query Neighborhood Hits	125	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.827722 (rank : 16)	θ value	9.83387e-39 (rank : 16)
Query Neighborhood Hits	125	Target Neighborhood Hits	369	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

KCNH7_MOUSE
NC score	0.809297 (rank : 17)	θ value	1.24399e-33 (rank : 19)
Query Neighborhood Hits	125	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH2_HUMAN
NC score	0.808740 (rank : 18)	θ value	2.67802e-36 (rank : 17)
Query Neighborhood Hits	125	Target Neighborhood Hits	158	Shared Neighborhood Hits	39
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
NC score	0.808631 (rank : 19)	θ value	2.67802e-36 (rank : 18)
Query Neighborhood Hits	125	Target Neighborhood Hits	165	Shared Neighborhood Hits	39
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH6_HUMAN
NC score	0.808593 (rank : 20)	θ value	1.6247e-33 (rank : 20)
Query Neighborhood Hits	125	Target Neighborhood Hits	222	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH4_HUMAN
NC score	0.804260 (rank : 21)	θ value	6.17384e-33 (rank : 21)
Query Neighborhood Hits	125	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH7_HUMAN
NC score	0.804196 (rank : 22)	θ value	2.19584e-30 (rank : 24)
Query Neighborhood Hits	125	Target Neighborhood Hits	107	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH8_HUMAN
NC score	0.802989 (rank : 23)	θ value	8.06329e-33 (rank : 22)
Query Neighborhood Hits	125	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH3_HUMAN
NC score	0.793382 (rank : 24)	θ value	8.91499e-32 (rank : 23)
Query Neighborhood Hits	125	Target Neighborhood Hits	148	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.793261 (rank : 25)	θ value	3.17079e-29 (rank : 25)
Query Neighborhood Hits	125	Target Neighborhood Hits	133	Shared Neighborhood Hits	33
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH5_MOUSE
NC score	0.793150 (rank : 26)	θ value	3.28125e-26 (rank : 29)
Query Neighborhood Hits	125	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.792898 (rank : 27)	θ value	3.28125e-26 (rank : 28)
Query Neighborhood Hits	125	Target Neighborhood Hits	99	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH1_MOUSE
NC score	0.789882 (rank : 28)	θ value	7.80994e-28 (rank : 27)
Query Neighborhood Hits	125	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.789552 (rank : 29)	θ value	7.80994e-28 (rank : 26)
Query Neighborhood Hits	125	Target Neighborhood Hits	98	Shared Neighborhood Hits	37
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KAP0_HUMAN
NC score	0.254312 (rank : 30)	θ value	0.0252991 (rank : 38)
Query Neighborhood Hits	125	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP1_HUMAN
NC score	0.238977 (rank : 31)	θ value	0.00298849 (rank : 35)
Query Neighborhood Hits	125	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.237319 (rank : 32)	θ value	0.0330416 (rank : 40)
Query Neighborhood Hits	125	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_MOUSE
NC score	0.233556 (rank : 33)	θ value	0.00665767 (rank : 36)
Query Neighborhood Hits	125	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP3_MOUSE
NC score	0.199176 (rank : 34)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	125	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.193156 (rank : 35)	θ value	0.163984 (rank : 46)
Query Neighborhood Hits	125	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
NC score	0.184205 (rank : 36)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	125	Target Neighborhood Hits	44	Shared Neighborhood Hits	28
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.180963 (rank : 37)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	125	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

CT152_MOUSE
NC score	0.153239 (rank : 38)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	125	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CT152_HUMAN
NC score	0.119001 (rank : 39)	θ value	1.06291 (rank : 56)
Query Neighborhood Hits	125	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KCNKH_HUMAN
NC score	0.101937 (rank : 40)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	125	Target Neighborhood Hits	89	Shared Neighborhood Hits	16
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

KGP1B_MOUSE
NC score	0.071461 (rank : 41)	θ value	0.00035302 (rank : 30)
Query Neighborhood Hits	125	Target Neighborhood Hits	922	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.071238 (rank : 42)	θ value	0.000461057 (rank : 32)
Query Neighborhood Hits	125	Target Neighborhood Hits	921	Shared Neighborhood Hits	49
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.070974 (rank : 43)	θ value	0.000461057 (rank : 31)
Query Neighborhood Hits	125	Target Neighborhood Hits	901	Shared Neighborhood Hits	47
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

SMC4_MOUSE
NC score	0.070248 (rank : 44)	θ value	0.0252991 (rank : 39)
Query Neighborhood Hits	125	Target Neighborhood Hits	830	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

KGP2_HUMAN
NC score	0.069377 (rank : 45)	θ value	0.00134147 (rank : 33)
Query Neighborhood Hits	125	Target Neighborhood Hits	1023	Shared Neighborhood Hits	63
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.069147 (rank : 46)	θ value	0.00134147 (rank : 34)
Query Neighborhood Hits	125	Target Neighborhood Hits	1029	Shared Neighborhood Hits	66
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KCNKF_HUMAN
NC score	0.067998 (rank : 47)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	125	Target Neighborhood Hits	87	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.065804 (rank : 48)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	125	Target Neighborhood Hits	86	Shared Neighborhood Hits	16
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

RPGF4_MOUSE
NC score	0.065722 (rank : 49)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	125	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

KCNK2_MOUSE
NC score	0.065396 (rank : 50)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK6_HUMAN
NC score	0.063989 (rank : 51)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	125	Target Neighborhood Hits	79	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

SMC4_HUMAN
NC score	0.063966 (rank : 52)	θ value	0.0193708 (rank : 37)
Query Neighborhood Hits	125	Target Neighborhood Hits	937	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

KCNK3_HUMAN
NC score	0.063266 (rank : 53)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

RPGF4_HUMAN
NC score	0.062992 (rank : 54)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	125	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF3_MOUSE
NC score	0.062631 (rank : 55)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	125	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

KCNKA_HUMAN
NC score	0.061528 (rank : 56)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	125	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNK3_MOUSE
NC score	0.061388 (rank : 57)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	125	Target Neighborhood Hits	93	Shared Neighborhood Hits	16
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

RPGF3_HUMAN
NC score	0.056207 (rank : 58)	θ value	2.36792 (rank : 77)
Query Neighborhood Hits	125	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

KCNK4_HUMAN
NC score	0.055875 (rank : 59)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	125	Target Neighborhood Hits	109	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNKG_HUMAN
NC score	0.054036 (rank : 60)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	125	Target Neighborhood Hits	90	Shared Neighborhood Hits	16
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

MAP1A_HUMAN
NC score	0.045946 (rank : 61)	θ value	0.62314 (rank : 51)
Query Neighborhood Hits	125	Target Neighborhood Hits	1626	Shared Neighborhood Hits	69
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

HMMR_MOUSE
NC score	0.044250 (rank : 62)	θ value	0.163984 (rank : 44)
Query Neighborhood Hits	125	Target Neighborhood Hits	1178	Shared Neighborhood Hits	68
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

MYH3_HUMAN
NC score	0.042851 (rank : 63)	θ value	0.0431538 (rank : 41)
Query Neighborhood Hits	125	Target Neighborhood Hits	1660	Shared Neighborhood Hits	73
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

JIP4_HUMAN
NC score	0.042660 (rank : 64)	θ value	0.0736092 (rank : 42)
Query Neighborhood Hits	125	Target Neighborhood Hits	585	Shared Neighborhood Hits	52
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

KCNK5_HUMAN
NC score	0.042438 (rank : 65)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	125	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	O95279	Gene names	KCNK5, TASK2
Domain Architecture
Description	Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2).

MYH1_MOUSE
NC score	0.042342 (rank : 66)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	125	Target Neighborhood Hits	1461	Shared Neighborhood Hits	73
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_MOUSE
NC score	0.042329 (rank : 67)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	125	Target Neighborhood Hits	1476	Shared Neighborhood Hits	72
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH14_MOUSE
NC score	0.042218 (rank : 68)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	125	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH7_HUMAN
NC score	0.042176 (rank : 69)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	125	Target Neighborhood Hits	1559	Shared Neighborhood Hits	73
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH9_MOUSE
NC score	0.041620 (rank : 70)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	125	Target Neighborhood Hits	1829	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH6_HUMAN
NC score	0.041619 (rank : 71)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	125	Target Neighborhood Hits	1426	Shared Neighborhood Hits	71
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH2_HUMAN
NC score	0.041524 (rank : 72)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	125	Target Neighborhood Hits	1491	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH6_MOUSE
NC score	0.041458 (rank : 73)	θ value	2.36792 (rank : 75)
Query Neighborhood Hits	125	Target Neighborhood Hits	1501	Shared Neighborhood Hits	72
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH1_HUMAN
NC score	0.041438 (rank : 74)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	125	Target Neighborhood Hits	1478	Shared Neighborhood Hits	72
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH8_HUMAN
NC score	0.041095 (rank : 75)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	125	Target Neighborhood Hits	1610	Shared Neighborhood Hits	72
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_HUMAN
NC score	0.041016 (rank : 76)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	125	Target Neighborhood Hits	1377	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

MYH10_HUMAN
NC score	0.040586 (rank : 77)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	125	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH8_MOUSE
NC score	0.040056 (rank : 78)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	125	Target Neighborhood Hits	1600	Shared Neighborhood Hits	71
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH10_MOUSE
NC score	0.039901 (rank : 79)	θ value	1.06291 (rank : 58)
Query Neighborhood Hits	125	Target Neighborhood Hits	1612	Shared Neighborhood Hits	69
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

JIP4_MOUSE
NC score	0.039886 (rank : 80)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	125	Target Neighborhood Hits	593	Shared Neighborhood Hits	51
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

MYH11_MOUSE
NC score	0.038784 (rank : 81)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	125	Target Neighborhood Hits	1777	Shared Neighborhood Hits	70
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_HUMAN
NC score	0.038502 (rank : 82)	θ value	0.62314 (rank : 52)
Query Neighborhood Hits	125	Target Neighborhood Hits	1806	Shared Neighborhood Hits	69
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

GOGA3_HUMAN
NC score	0.037834 (rank : 83)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	125	Target Neighborhood Hits	1317	Shared Neighborhood Hits	70
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MY18A_HUMAN
NC score	0.036861 (rank : 84)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	125	Target Neighborhood Hits	1929	Shared Neighborhood Hits	72
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CROCC_HUMAN
NC score	0.036437 (rank : 85)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	125	Target Neighborhood Hits	1409	Shared Neighborhood Hits	69
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

GOGA3_MOUSE
NC score	0.036164 (rank : 86)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	125	Target Neighborhood Hits	1437	Shared Neighborhood Hits	70
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

MYO5A_MOUSE
NC score	0.036156 (rank : 87)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	125	Target Neighborhood Hits	1117	Shared Neighborhood Hits	67
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

GOGB1_HUMAN
NC score	0.035990 (rank : 88)	θ value	1.06291 (rank : 57)
Query Neighborhood Hits	125	Target Neighborhood Hits	2297	Shared Neighborhood Hits	76
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

TPR_HUMAN
NC score	0.035984 (rank : 89)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	125	Target Neighborhood Hits	1921	Shared Neighborhood Hits	75
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

MY18A_MOUSE
NC score	0.035981 (rank : 90)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	125	Target Neighborhood Hits	1989	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

FYCO1_MOUSE
NC score	0.035820 (rank : 91)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	125	Target Neighborhood Hits	1059	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

TPM3_MOUSE
NC score	0.035447 (rank : 92)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	125	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

KCNQ3_MOUSE
NC score	0.034847 (rank : 93)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	125	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

SYCP1_MOUSE
NC score	0.034805 (rank : 94)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	125	Target Neighborhood Hits	1456	Shared Neighborhood Hits	71
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CASP_HUMAN
NC score	0.034529 (rank : 95)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	125	Target Neighborhood Hits	1131	Shared Neighborhood Hits	65
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

TPM2_MOUSE
NC score	0.034339 (rank : 96)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	125	Target Neighborhood Hits	676	Shared Neighborhood Hits	60
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

KCNQ3_HUMAN
NC score	0.034334 (rank : 97)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	125	Target Neighborhood Hits	114	Shared Neighborhood Hits	16
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

CASP_MOUSE
NC score	0.033925 (rank : 98)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	125	Target Neighborhood Hits	1152	Shared Neighborhood Hits	67
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

MPP9_HUMAN
NC score	0.033723 (rank : 99)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	125	Target Neighborhood Hits	529	Shared Neighborhood Hits	57
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

LIPA2_HUMAN
NC score	0.033104 (rank : 100)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	125	Target Neighborhood Hits	1044	Shared Neighborhood Hits	66
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

AKAP9_HUMAN
NC score	0.032689 (rank : 101)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	125	Target Neighborhood Hits	1710	Shared Neighborhood Hits	72
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

HOOK1_HUMAN
NC score	0.031912 (rank : 102)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	125	Target Neighborhood Hits	942	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

EEA1_HUMAN
NC score	0.031856 (rank : 103)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	125	Target Neighborhood Hits	1796	Shared Neighborhood Hits	73
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

LIPA2_MOUSE
NC score	0.031732 (rank : 104)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	125	Target Neighborhood Hits	1282	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

REST_MOUSE
NC score	0.031562 (rank : 105)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	125	Target Neighborhood Hits	1506	Shared Neighborhood Hits	69
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

NUMA1_HUMAN
NC score	0.031209 (rank : 106)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	125	Target Neighborhood Hits	1523	Shared Neighborhood Hits	66
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RRBP1_HUMAN
NC score	0.031148 (rank : 107)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	125	Target Neighborhood Hits	1306	Shared Neighborhood Hits	66
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

TPM2_HUMAN
NC score	0.031107 (rank : 108)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	125	Target Neighborhood Hits	677	Shared Neighborhood Hits	60
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

LIPA1_HUMAN
NC score	0.030737 (rank : 109)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	125	Target Neighborhood Hits	1294	Shared Neighborhood Hits	67
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

RRBP1_MOUSE
NC score	0.030636 (rank : 110)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	125	Target Neighborhood Hits	1650	Shared Neighborhood Hits	70
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

LIPA3_MOUSE
NC score	0.030215 (rank : 111)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	125	Target Neighborhood Hits	636	Shared Neighborhood Hits	56
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

CUTL1_HUMAN
NC score	0.029285 (rank : 112)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	125	Target Neighborhood Hits	1574	Shared Neighborhood Hits	65
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CENPE_HUMAN
NC score	0.029220 (rank : 113)	θ value	1.06291 (rank : 55)
Query Neighborhood Hits	125	Target Neighborhood Hits	2060	Shared Neighborhood Hits	72
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CGRE1_HUMAN
NC score	0.028854 (rank : 114)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	125	Target Neighborhood Hits	354	Shared Neighborhood Hits	6
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CCD93_HUMAN
NC score	0.028433 (rank : 115)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	125	Target Neighborhood Hits	600	Shared Neighborhood Hits	60
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

UACA_MOUSE
NC score	0.027724 (rank : 116)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	125	Target Neighborhood Hits	1620	Shared Neighborhood Hits	67
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

HOOK1_MOUSE
NC score	0.027571 (rank : 117)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	125	Target Neighborhood Hits	910	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

UACA_HUMAN
NC score	0.027173 (rank : 118)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	125	Target Neighborhood Hits	1622	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

BCN1_MOUSE
NC score	0.024339 (rank : 119)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	125	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

PLEC1_HUMAN
NC score	0.022382 (rank : 120)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	125	Target Neighborhood Hits	1326	Shared Neighborhood Hits	61
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

EZRI_MOUSE
NC score	0.021071 (rank : 121)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	125	Target Neighborhood Hits	693	Shared Neighborhood Hits	56
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RADI_HUMAN
NC score	0.020932 (rank : 122)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	125	Target Neighborhood Hits	741	Shared Neighborhood Hits	57
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

EZRI_HUMAN
NC score	0.020655 (rank : 123)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	125	Target Neighborhood Hits	663	Shared Neighborhood Hits	56
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

KIFC3_HUMAN
NC score	0.019913 (rank : 124)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	125	Target Neighborhood Hits	619	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KIFC3_MOUSE
NC score	0.019002 (rank : 125)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	125	Target Neighborhood Hits	571	Shared Neighborhood Hits	61
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

X3CL1_MOUSE
NC score	0.018740 (rank : 126)	θ value	0.813845 (rank : 54)
Query Neighborhood Hits	125	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	O35188, O35933	Gene names	Cx3cl1, Cx3c, Fkn, Scyd1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

SIL1_MOUSE
NC score	0.014706 (rank : 127)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	125	Target Neighborhood Hits	68	Shared Neighborhood Hits	19
SwissProt Accessions	Q9EPK6, Q91V34	Gene names	Sil1
Domain Architecture	No domain graphic available
Description	Nucleotide exchange factor SIL1 precursor.

WDR47_HUMAN
NC score	0.013878 (rank : 128)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	125	Target Neighborhood Hits	295	Shared Neighborhood Hits	6
SwissProt Accessions	O94967, Q8IXT7, Q8IYU9	Gene names	WDR47, KIAA0893
Domain Architecture	No domain graphic available
Description	WD repeat protein 47.

KLDC4_MOUSE
NC score	0.011804 (rank : 129)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	125	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q921I2, Q8CIK0	Gene names	Klhdc4
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 4.

ANR11_HUMAN
NC score	0.010667 (rank : 130)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	125	Target Neighborhood Hits	1289	Shared Neighborhood Hits	47
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

K1C20_HUMAN
NC score	0.010409 (rank : 131)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	125	Target Neighborhood Hits	468	Shared Neighborhood Hits	49
SwissProt Accessions	P35900	Gene names	KRT20
Domain Architecture
Description	Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT).

WRN_MOUSE
NC score	0.007949 (rank : 132)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	125	Target Neighborhood Hits	295	Shared Neighborhood Hits	16
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

HAX1_HUMAN
NC score	0.007622 (rank : 133)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	125	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	O00165, Q96AU4, Q9BS80	Gene names	HAX1, HS1BP1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

TNIK_HUMAN
NC score	0.007156 (rank : 134)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	125	Target Neighborhood Hits	1570	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

PK3CB_MOUSE
NC score	0.007019 (rank : 135)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	125	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

AP4S1_HUMAN
NC score	0.003964 (rank : 136)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	125	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y587	Gene names	AP4S1
Domain Architecture
Description	AP-4 complex subunit sigma-1 (Adapter-related protein complex 4 sigma- 1 subunit) (Sigma subunit of AP-4) (AP-4 adapter complex sigma subunit).

CES3_MOUSE
NC score	0.001802 (rank : 137)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	125	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCT4, Q91ZV9, Q924V8, Q9ULY1	Gene names	Ces3, Ces1
Domain Architecture	No domain graphic available
Description	Carboxylesterase 3 precursor (EC 3.1.1.1) (Triacylglycerol hydrolase) (TGH).

TEP1_MOUSE
NC score	0.000370 (rank : 138)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	125	Target Neighborhood Hits	344	Shared Neighborhood Hits	3
SwissProt Accessions	P97499	Gene names	Tep1, Tp1
Domain Architecture
Description	Telomerase protein component 1 (Telomerase-associated protein 1) (Telomerase protein 1) (p240) (p80 homolog).

TRFR_HUMAN
NC score	-0.003875 (rank : 139)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	125	Target Neighborhood Hits	864	Shared Neighborhood Hits	2
SwissProt Accessions	P34981	Gene names	TRHR
Domain Architecture
Description	Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor).