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Network neighborhood for query Sequence : CNGA2_MOUSE

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CNGA2_MOUSE
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CNGA1_HUMAN
θ value	0 (rank : 1)	NC score	0.986766 (rank : 4)
Query Neighborhood Hits	86	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	0 (rank : 2)	NC score	0.982842 (rank : 5)
Query Neighborhood Hits	86	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA2_MOUSE
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_HUMAN
θ value	0 (rank : 4)	NC score	0.990035 (rank : 3)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	57
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
θ value	0 (rank : 5)	NC score	0.993471 (rank : 2)
Query Neighborhood Hits	86	Target Neighborhood Hits	84	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGB1_HUMAN
θ value	8.79181e-80 (rank : 6)	NC score	0.929931 (rank : 8)
Query Neighborhood Hits	86	Target Neighborhood Hits	222	Shared Neighborhood Hits	51
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_HUMAN
θ value	1.8332e-77 (rank : 7)	NC score	0.932830 (rank : 7)
Query Neighborhood Hits	86	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
θ value	2.39424e-77 (rank : 8)	NC score	0.944876 (rank : 6)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

HCN1_HUMAN
θ value	1.28137e-46 (rank : 9)	NC score	0.868271 (rank : 9)
Query Neighborhood Hits	86	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	1.28137e-46 (rank : 10)	NC score	0.864423 (rank : 10)
Query Neighborhood Hits	86	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN2_MOUSE
θ value	1.19932e-44 (rank : 11)	NC score	0.851028 (rank : 13)
Query Neighborhood Hits	86	Target Neighborhood Hits	278	Shared Neighborhood Hits	46
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
θ value	7.77379e-44 (rank : 12)	NC score	0.847229 (rank : 14)
Query Neighborhood Hits	86	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN2_HUMAN
θ value	1.01529e-43 (rank : 13)	NC score	0.840472 (rank : 16)
Query Neighborhood Hits	86	Target Neighborhood Hits	369	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN4_MOUSE
θ value	8.59492e-43 (rank : 14)	NC score	0.845351 (rank : 15)
Query Neighborhood Hits	86	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN3_MOUSE
θ value	1.46607e-42 (rank : 15)	NC score	0.864173 (rank : 11)
Query Neighborhood Hits	86	Target Neighborhood Hits	112	Shared Neighborhood Hits	41
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN3_HUMAN
θ value	2.50074e-42 (rank : 16)	NC score	0.863355 (rank : 12)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

KCNH7_MOUSE
θ value	2.19075e-38 (rank : 17)	NC score	0.824673 (rank : 17)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH6_HUMAN
θ value	4.13158e-37 (rank : 18)	NC score	0.823297 (rank : 18)
Query Neighborhood Hits	86	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH7_HUMAN
θ value	5.96599e-36 (rank : 19)	NC score	0.819432 (rank : 21)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH5_HUMAN
θ value	2.96089e-35 (rank : 20)	NC score	0.812577 (rank : 25)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH5_MOUSE
θ value	2.96089e-35 (rank : 21)	NC score	0.812876 (rank : 24)
Query Neighborhood Hits	86	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH2_HUMAN
θ value	3.86705e-35 (rank : 22)	NC score	0.822833 (rank : 19)
Query Neighborhood Hits	86	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	3.86705e-35 (rank : 23)	NC score	0.822740 (rank : 20)
Query Neighborhood Hits	86	Target Neighborhood Hits	165	Shared Neighborhood Hits	42
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH1_HUMAN
θ value	2.12192e-33 (rank : 24)	NC score	0.808351 (rank : 27)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	2.12192e-33 (rank : 25)	NC score	0.808592 (rank : 26)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH8_HUMAN
θ value	4.72714e-33 (rank : 26)	NC score	0.817702 (rank : 23)
Query Neighborhood Hits	86	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH3_MOUSE
θ value	8.91499e-32 (rank : 27)	NC score	0.806599 (rank : 29)
Query Neighborhood Hits	86	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KCNH3_HUMAN
θ value	1.28732e-30 (rank : 28)	NC score	0.806607 (rank : 28)
Query Neighborhood Hits	86	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH4_HUMAN
θ value	1.28732e-30 (rank : 29)	NC score	0.818220 (rank : 22)
Query Neighborhood Hits	86	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KGP2_HUMAN
θ value	0.00102713 (rank : 30)	NC score	0.066120 (rank : 49)
Query Neighborhood Hits	86	Target Neighborhood Hits	1023	Shared Neighborhood Hits	48
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	0.00102713 (rank : 31)	NC score	0.065792 (rank : 50)
Query Neighborhood Hits	86	Target Neighborhood Hits	1029	Shared Neighborhood Hits	46
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KAP3_MOUSE
θ value	0.00390308 (rank : 32)	NC score	0.193678 (rank : 34)
Query Neighborhood Hits	86	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
θ value	0.0148317 (rank : 33)	NC score	0.187714 (rank : 35)
Query Neighborhood Hits	86	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KGP1A_HUMAN
θ value	0.0252991 (rank : 34)	NC score	0.067399 (rank : 48)
Query Neighborhood Hits	86	Target Neighborhood Hits	901	Shared Neighborhood Hits	46
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	0.0252991 (rank : 35)	NC score	0.067589 (rank : 47)
Query Neighborhood Hits	86	Target Neighborhood Hits	921	Shared Neighborhood Hits	46
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	0.0252991 (rank : 36)	NC score	0.067856 (rank : 45)
Query Neighborhood Hits	86	Target Neighborhood Hits	922	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CT152_HUMAN
θ value	0.0330416 (rank : 37)	NC score	0.122488 (rank : 39)
Query Neighborhood Hits	86	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KAP1_HUMAN
θ value	0.0431538 (rank : 38)	NC score	0.227699 (rank : 31)
Query Neighborhood Hits	86	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

CHM4C_MOUSE
θ value	0.0563607 (rank : 39)	NC score	0.034770 (rank : 64)
Query Neighborhood Hits	86	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D7F7, Q3TVD7, Q9CWH8	Gene names	Chmp4c
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c).

GOGA1_HUMAN
θ value	0.0961366 (rank : 40)	NC score	0.019433 (rank : 72)
Query Neighborhood Hits	86	Target Neighborhood Hits	1222	Shared Neighborhood Hits	37
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KAP1_MOUSE
θ value	0.0961366 (rank : 41)	NC score	0.222362 (rank : 33)
Query Neighborhood Hits	86	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KCMA1_HUMAN
θ value	0.0961366 (rank : 42)	NC score	0.056100 (rank : 59)
Query Neighborhood Hits	86	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCMA1_MOUSE
θ value	0.0961366 (rank : 43)	NC score	0.056148 (rank : 58)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KAP0_HUMAN
θ value	0.125558 (rank : 44)	NC score	0.244121 (rank : 30)
Query Neighborhood Hits	86	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	0.163984 (rank : 45)	NC score	0.226240 (rank : 32)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

MYH14_HUMAN
θ value	0.21417 (rank : 46)	NC score	0.017312 (rank : 82)
Query Neighborhood Hits	86	Target Neighborhood Hits	995	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

RPGF4_HUMAN
θ value	0.279714 (rank : 47)	NC score	0.070613 (rank : 42)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	0.279714 (rank : 48)	NC score	0.073430 (rank : 41)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

MYH14_MOUSE
θ value	0.365318 (rank : 49)	NC score	0.019268 (rank : 74)
Query Neighborhood Hits	86	Target Neighborhood Hits	1225	Shared Neighborhood Hits	35
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

SMC4_MOUSE
θ value	0.365318 (rank : 50)	NC score	0.042938 (rank : 62)
Query Neighborhood Hits	86	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

CHM4C_HUMAN
θ value	0.47712 (rank : 51)	NC score	0.028812 (rank : 67)
Query Neighborhood Hits	86	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	Q96CF2	Gene names	CHMP4C, SHAX3
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (Vacuolar protein sorting 7-3) (SNF7-3) (hSnf7-3) (SNF7 homolog associated with Alix 3).

TPM3_HUMAN
θ value	0.47712 (rank : 52)	NC score	0.017977 (rank : 79)
Query Neighborhood Hits	86	Target Neighborhood Hits	689	Shared Neighborhood Hits	28
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

TPM3_MOUSE
θ value	0.47712 (rank : 53)	NC score	0.019292 (rank : 73)
Query Neighborhood Hits	86	Target Neighborhood Hits	676	Shared Neighborhood Hits	28
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

HMMR_MOUSE
θ value	0.62314 (rank : 54)	NC score	0.024333 (rank : 70)
Query Neighborhood Hits	86	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

MAP1A_HUMAN
θ value	0.813845 (rank : 55)	NC score	0.034809 (rank : 63)
Query Neighborhood Hits	86	Target Neighborhood Hits	1626	Shared Neighborhood Hits	34
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

PLSB_HUMAN
θ value	0.813845 (rank : 56)	NC score	0.017659 (rank : 81)
Query Neighborhood Hits	86	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HCL2, Q5VW51	Gene names	GPAM, KIAA1560
Domain Architecture
Description	Glycerol-3-phosphate acyltransferase, mitochondrial precursor (EC 2.3.1.15) (GPAT).

CT152_MOUSE
θ value	1.38821 (rank : 57)	NC score	0.155294 (rank : 38)
Query Neighborhood Hits	86	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

HMMR_HUMAN
θ value	1.38821 (rank : 58)	NC score	0.016022 (rank : 85)
Query Neighborhood Hits	86	Target Neighborhood Hits	1082	Shared Neighborhood Hits	31
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

MYH9_HUMAN
θ value	1.38821 (rank : 59)	NC score	0.017733 (rank : 80)
Query Neighborhood Hits	86	Target Neighborhood Hits	1762	Shared Neighborhood Hits	38
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	1.38821 (rank : 60)	NC score	0.018370 (rank : 77)
Query Neighborhood Hits	86	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

STXB4_MOUSE
θ value	1.38821 (rank : 61)	NC score	0.018996 (rank : 75)
Query Neighborhood Hits	86	Target Neighborhood Hits	629	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

F107B_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.026922 (rank : 69)
Query Neighborhood Hits	86	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H098	Gene names	FAM107B, C10orf45
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

F107B_MOUSE
θ value	1.81305 (rank : 63)	NC score	0.026929 (rank : 68)
Query Neighborhood Hits	86	Target Neighborhood Hits	126	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TGF2	Gene names	Fam107b
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

KTN1_MOUSE
θ value	1.81305 (rank : 64)	NC score	0.015110 (rank : 87)
Query Neighborhood Hits	86	Target Neighborhood Hits	1324	Shared Neighborhood Hits	34
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

A16L1_MOUSE
θ value	2.36792 (rank : 65)	NC score	0.006947 (rank : 99)
Query Neighborhood Hits	86	Target Neighborhood Hits	776	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

GOGA1_MOUSE
θ value	2.36792 (rank : 66)	NC score	0.022466 (rank : 71)
Query Neighborhood Hits	86	Target Neighborhood Hits	994	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MYH10_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.016749 (rank : 83)
Query Neighborhood Hits	86	Target Neighborhood Hits	1620	Shared Neighborhood Hits	34
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

AKAP9_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.014363 (rank : 90)
Query Neighborhood Hits	86	Target Neighborhood Hits	1710	Shared Neighborhood Hits	39
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

MYO5A_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.014615 (rank : 89)
Query Neighborhood Hits	86	Target Neighborhood Hits	1092	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

REST_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.010601 (rank : 94)
Query Neighborhood Hits	86	Target Neighborhood Hits	1605	Shared Neighborhood Hits	37
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SNX5_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.009005 (rank : 97)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5X3, Q52LC4, Q9BWP0	Gene names	SNX5
Domain Architecture
Description	Sorting nexin-5.

SYCP1_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.015950 (rank : 86)
Query Neighborhood Hits	86	Target Neighborhood Hits	1456	Shared Neighborhood Hits	39
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TITIN_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.001602 (rank : 101)
Query Neighborhood Hits	86	Target Neighborhood Hits	2923	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CYTSA_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.011420 (rank : 93)
Query Neighborhood Hits	86	Target Neighborhood Hits	1104	Shared Neighborhood Hits	31
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

MYH10_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.016209 (rank : 84)
Query Neighborhood Hits	86	Target Neighborhood Hits	1612	Shared Neighborhood Hits	34
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

STXB4_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.018056 (rank : 78)
Query Neighborhood Hits	86	Target Neighborhood Hits	616	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TPM2_MOUSE
θ value	5.27518 (rank : 77)	NC score	0.018422 (rank : 76)
Query Neighborhood Hits	86	Target Neighborhood Hits	676	Shared Neighborhood Hits	30
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

CYTSA_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.012444 (rank : 92)
Query Neighborhood Hits	86	Target Neighborhood Hits	1138	Shared Neighborhood Hits	32
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

GBP1_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.006153 (rank : 100)
Query Neighborhood Hits	86	Target Neighborhood Hits	339	Shared Neighborhood Hits	21
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

KCNQ3_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.034203 (rank : 66)
Query Neighborhood Hits	86	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KTN1_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.013373 (rank : 91)
Query Neighborhood Hits	86	Target Neighborhood Hits	1197	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MAP9_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.010542 (rank : 95)
Query Neighborhood Hits	86	Target Neighborhood Hits	529	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MYO5A_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.014722 (rank : 88)
Query Neighborhood Hits	86	Target Neighborhood Hits	1117	Shared Neighborhood Hits	35
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

PK3CB_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.007246 (rank : 98)
Query Neighborhood Hits	86	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

GOGA4_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.009836 (rank : 96)
Query Neighborhood Hits	86	Target Neighborhood Hits	2034	Shared Neighborhood Hits	37
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

KCNQ3_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.034623 (rank : 65)
Query Neighborhood Hits	86	Target Neighborhood Hits	105	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KAP2_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.175743 (rank : 37)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.178982 (rank : 36)
Query Neighborhood Hits	86	Target Neighborhood Hits	44	Shared Neighborhood Hits	28
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KCNK2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.068281 (rank : 44)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KCNK2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.067694 (rank : 46)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KCNK3_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.065367 (rank : 52)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

KCNK3_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.063442 (rank : 55)
Query Neighborhood Hits	86	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.059568 (rank : 56)
Query Neighborhood Hits	86	Target Neighborhood Hits	109	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

KCNK4_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.051720 (rank : 61)
Query Neighborhood Hits	86	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

KCNK6_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.065496 (rank : 51)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNKA_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.063655 (rank : 54)
Query Neighborhood Hits	86	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNKF_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.069396 (rank : 43)
Query Neighborhood Hits	86	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNKG_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.056022 (rank : 60)
Query Neighborhood Hits	86	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KCNKH_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.105806 (rank : 40)
Query Neighborhood Hits	86	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

RPGF3_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.057647 (rank : 57)
Query Neighborhood Hits	86	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.064043 (rank : 53)
Query Neighborhood Hits	86	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

Hits sorted by NC score

CNGA2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA3_MOUSE
NC score	0.993471 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	86	Target Neighborhood Hits	84	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.990035 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	57
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA1_HUMAN
NC score	0.986766 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	86	Target Neighborhood Hits	149	Shared Neighborhood Hits	48
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
NC score	0.982842 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	86	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGB3_MOUSE
NC score	0.944876 (rank : 6)	θ value	2.39424e-77 (rank : 8)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.932830 (rank : 7)	θ value	1.8332e-77 (rank : 7)
Query Neighborhood Hits	86	Target Neighborhood Hits	206	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB1_HUMAN
NC score	0.929931 (rank : 8)	θ value	8.79181e-80 (rank : 6)
Query Neighborhood Hits	86	Target Neighborhood Hits	222	Shared Neighborhood Hits	51
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

HCN1_HUMAN
NC score	0.868271 (rank : 9)	θ value	1.28137e-46 (rank : 9)
Query Neighborhood Hits	86	Target Neighborhood Hits	120	Shared Neighborhood Hits	43
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
NC score	0.864423 (rank : 10)	θ value	1.28137e-46 (rank : 10)
Query Neighborhood Hits	86	Target Neighborhood Hits	172	Shared Neighborhood Hits	44
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_MOUSE
NC score	0.864173 (rank : 11)	θ value	1.46607e-42 (rank : 15)
Query Neighborhood Hits	86	Target Neighborhood Hits	112	Shared Neighborhood Hits	41
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN3_HUMAN
NC score	0.863355 (rank : 12)	θ value	2.50074e-42 (rank : 16)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN2_MOUSE
NC score	0.851028 (rank : 13)	θ value	1.19932e-44 (rank : 11)
Query Neighborhood Hits	86	Target Neighborhood Hits	278	Shared Neighborhood Hits	46
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN4_HUMAN
NC score	0.847229 (rank : 14)	θ value	7.77379e-44 (rank : 12)
Query Neighborhood Hits	86	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
NC score	0.845351 (rank : 15)	θ value	8.59492e-43 (rank : 14)
Query Neighborhood Hits	86	Target Neighborhood Hits	284	Shared Neighborhood Hits	42
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN2_HUMAN
NC score	0.840472 (rank : 16)	θ value	1.01529e-43 (rank : 13)
Query Neighborhood Hits	86	Target Neighborhood Hits	369	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

KCNH7_MOUSE
NC score	0.824673 (rank : 17)	θ value	2.19075e-38 (rank : 17)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH6_HUMAN
NC score	0.823297 (rank : 18)	θ value	4.13158e-37 (rank : 18)
Query Neighborhood Hits	86	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH2_HUMAN
NC score	0.822833 (rank : 19)	θ value	3.86705e-35 (rank : 22)
Query Neighborhood Hits	86	Target Neighborhood Hits	158	Shared Neighborhood Hits	42
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
NC score	0.822740 (rank : 20)	θ value	3.86705e-35 (rank : 23)
Query Neighborhood Hits	86	Target Neighborhood Hits	165	Shared Neighborhood Hits	42
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH7_HUMAN
NC score	0.819432 (rank : 21)	θ value	5.96599e-36 (rank : 19)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH4_HUMAN
NC score	0.818220 (rank : 22)	θ value	1.28732e-30 (rank : 29)
Query Neighborhood Hits	86	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UQ05	Gene names	KCNH4
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 4 (Voltage-gated potassium channel subunit Kv12.3) (Ether-a-go-go-like potassium channel 1) (ELK channel 1) (ELK1) (Brain-specific eag-like channel 2) (BEC2).

KCNH8_HUMAN
NC score	0.817702 (rank : 23)	θ value	4.72714e-33 (rank : 26)
Query Neighborhood Hits	86	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q96L42	Gene names	KCNH8
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 8 (Voltage-gated potassium channel subunit Kv12.1) (Ether-a-go-go-like potassium channel 3) (ELK channel 3) (ELK3) (ELK1) (hElk1).

KCNH5_MOUSE
NC score	0.812876 (rank : 24)	θ value	2.96089e-35 (rank : 21)
Query Neighborhood Hits	86	Target Neighborhood Hits	102	Shared Neighborhood Hits	34
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KCNH5_HUMAN
NC score	0.812577 (rank : 25)	θ value	2.96089e-35 (rank : 20)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NCM2	Gene names	KCNH5, EAG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

KCNH1_MOUSE
NC score	0.808592 (rank : 26)	θ value	2.12192e-33 (rank : 25)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.808351 (rank : 27)	θ value	2.12192e-33 (rank : 24)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	36
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH3_HUMAN
NC score	0.806607 (rank : 28)	θ value	1.28732e-30 (rank : 28)
Query Neighborhood Hits	86	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KCNH3_MOUSE
NC score	0.806599 (rank : 29)	θ value	8.91499e-32 (rank : 27)
Query Neighborhood Hits	86	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

KAP0_HUMAN
NC score	0.244121 (rank : 30)	θ value	0.125558 (rank : 44)
Query Neighborhood Hits	86	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP1_HUMAN
NC score	0.227699 (rank : 31)	θ value	0.0431538 (rank : 38)
Query Neighborhood Hits	86	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.226240 (rank : 32)	θ value	0.163984 (rank : 45)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP1_MOUSE
NC score	0.222362 (rank : 33)	θ value	0.0961366 (rank : 41)
Query Neighborhood Hits	86	Target Neighborhood Hits	49	Shared Neighborhood Hits	36
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP3_MOUSE
NC score	0.193678 (rank : 34)	θ value	0.00390308 (rank : 32)
Query Neighborhood Hits	86	Target Neighborhood Hits	43	Shared Neighborhood Hits	30
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.187714 (rank : 35)	θ value	0.0148317 (rank : 33)
Query Neighborhood Hits	86	Target Neighborhood Hits	40	Shared Neighborhood Hits	30
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
NC score	0.178982 (rank : 36)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	86	Target Neighborhood Hits	44	Shared Neighborhood Hits	28
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.175743 (rank : 37)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

CT152_MOUSE
NC score	0.155294 (rank : 38)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	86	Target Neighborhood Hits	38	Shared Neighborhood Hits	31
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

CT152_HUMAN
NC score	0.122488 (rank : 39)	θ value	0.0330416 (rank : 37)
Query Neighborhood Hits	86	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KCNKH_HUMAN
NC score	0.105806 (rank : 40)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	86	Target Neighborhood Hits	89	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T54, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592	Gene names	KCNK17, TALK2, TASK4
Domain Architecture
Description	Potassium channel subfamily K member 17 (TWIK-related alkaline pH- activated K(+) channel 2) (2P domain potassium channel Talk-2) (TWIK- related acid-sensitive K(+) channel 4) (TASK-4).

RPGF4_MOUSE
NC score	0.073430 (rank : 41)	θ value	0.279714 (rank : 48)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.070613 (rank : 42)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

KCNKF_HUMAN
NC score	0.069396 (rank : 43)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	86	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H427, Q9HBC8	Gene names	KCNK15, TASK5
Domain Architecture
Description	Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3).

KCNK2_HUMAN
NC score	0.068281 (rank : 44)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	O95069, Q9UNE3	Gene names	KCNK2, TREK, TREK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two-pore potassium channel TPKC1).

KGP1B_MOUSE
NC score	0.067856 (rank : 45)	θ value	0.0252991 (rank : 36)
Query Neighborhood Hits	86	Target Neighborhood Hits	922	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KCNK2_MOUSE
NC score	0.067694 (rank : 46)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	P97438	Gene names	Kcnk2
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (Two-pore potassium channel TPKC1) (TREK-1 K(+) channel subunit).

KGP1B_HUMAN
NC score	0.067589 (rank : 47)	θ value	0.0252991 (rank : 35)
Query Neighborhood Hits	86	Target Neighborhood Hits	921	Shared Neighborhood Hits	46
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1A_HUMAN
NC score	0.067399 (rank : 48)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	86	Target Neighborhood Hits	901	Shared Neighborhood Hits	46
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP2_HUMAN
NC score	0.066120 (rank : 49)	θ value	0.00102713 (rank : 30)
Query Neighborhood Hits	86	Target Neighborhood Hits	1023	Shared Neighborhood Hits	48
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.065792 (rank : 50)	θ value	0.00102713 (rank : 31)
Query Neighborhood Hits	86	Target Neighborhood Hits	1029	Shared Neighborhood Hits	46
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KCNK6_HUMAN
NC score	0.065496 (rank : 51)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y257, Q9HB47	Gene names	KCNK6, TOSS, TWIK2
Domain Architecture
Description	Potassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence).

KCNK3_HUMAN
NC score	0.065367 (rank : 52)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O14649	Gene names	KCNK3, TASK, TASK1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Two pore potassium channel KT3.1).

RPGF3_MOUSE
NC score	0.064043 (rank : 53)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	86	Target Neighborhood Hits	54	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

KCNKA_HUMAN
NC score	0.063655 (rank : 54)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	86	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	P57789, Q8TDK7, Q8TDK8, Q9HB59	Gene names	KCNK10, TREK2
Domain Architecture
Description	Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit).

KCNK3_MOUSE
NC score	0.063442 (rank : 55)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	86	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	O35111, O35163	Gene names	Kcnk3, Ctbak, Task, Task1
Domain Architecture
Description	Potassium channel subfamily K member 3 (Acid-sensitive potassium channel protein TASK-1) (TWIK-related acid-sensitive K(+) channel 1) (Cardiac two-pore background K(+) channel) (cTBAK-1) (Two pore potassium channel KT3.1).

KCNK4_HUMAN
NC score	0.059568 (rank : 56)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	86	Target Neighborhood Hits	109	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NYG8, Q96T94	Gene names	KCNK4, TRAAK
Domain Architecture
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK) (Two pore K(+) channel KT4.1).

RPGF3_HUMAN
NC score	0.057647 (rank : 57)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	86	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

KCMA1_MOUSE
NC score	0.056148 (rank : 58)	θ value	0.0961366 (rank : 43)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	Q08460, Q64703, Q8VHF1, Q9R196	Gene names	Kcnma1, Kcnma
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (mSlo) (mSlo1).

KCMA1_HUMAN
NC score	0.056100 (rank : 59)	θ value	0.0961366 (rank : 42)
Query Neighborhood Hits	86	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q96LG8, Q9UBB0, Q9UQK6	Gene names	KCNMA1, KCNMA
Domain Architecture
Description	Calcium-activated potassium channel subunit alpha 1 (Calcium-activated potassium channel, subfamily M subunit alpha 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha) (Slo1) (hSlo).

KCNKG_HUMAN
NC score	0.056022 (rank : 60)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	86	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T55, Q5TCF3, Q9H591	Gene names	KCNK16, TALK1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 16 (TWIK-related alkaline pH- activated K(+) channel 1) (2P domain potassium channel Talk-1).

KCNK4_MOUSE
NC score	0.051720 (rank : 61)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	86	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	O88454	Gene names	Kcnk4, Traak
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 4 (TWIK-related arachidonic acid- stimulated potassium channel protein) (TRAAK).

SMC4_MOUSE
NC score	0.042938 (rank : 62)	θ value	0.365318 (rank : 50)
Query Neighborhood Hits	86	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

MAP1A_HUMAN
NC score	0.034809 (rank : 63)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	86	Target Neighborhood Hits	1626	Shared Neighborhood Hits	34
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CHM4C_MOUSE
NC score	0.034770 (rank : 64)	θ value	0.0563607 (rank : 39)
Query Neighborhood Hits	86	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D7F7, Q3TVD7, Q9CWH8	Gene names	Chmp4c
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c).

KCNQ3_MOUSE
NC score	0.034623 (rank : 65)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	86	Target Neighborhood Hits	105	Shared Neighborhood Hits	16
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_HUMAN
NC score	0.034203 (rank : 66)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	86	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

CHM4C_HUMAN
NC score	0.028812 (rank : 67)	θ value	0.47712 (rank : 51)
Query Neighborhood Hits	86	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	Q96CF2	Gene names	CHMP4C, SHAX3
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 4c (Chromatin-modifying protein 4c) (CHMP4c) (Vacuolar protein sorting 7-3) (SNF7-3) (hSnf7-3) (SNF7 homolog associated with Alix 3).

F107B_MOUSE
NC score	0.026929 (rank : 68)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	86	Target Neighborhood Hits	126	Shared Neighborhood Hits	10
SwissProt Accessions	Q3TGF2	Gene names	Fam107b
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

F107B_HUMAN
NC score	0.026922 (rank : 69)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	86	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H098	Gene names	FAM107B, C10orf45
Domain Architecture	No domain graphic available
Description	Protein FAM107B.

HMMR_MOUSE
NC score	0.024333 (rank : 70)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	86	Target Neighborhood Hits	1178	Shared Neighborhood Hits	34
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

GOGA1_MOUSE
NC score	0.022466 (rank : 71)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	86	Target Neighborhood Hits	994	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA1_HUMAN
NC score	0.019433 (rank : 72)	θ value	0.0961366 (rank : 40)
Query Neighborhood Hits	86	Target Neighborhood Hits	1222	Shared Neighborhood Hits	37
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

TPM3_MOUSE
NC score	0.019292 (rank : 73)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	86	Target Neighborhood Hits	676	Shared Neighborhood Hits	28
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

MYH14_MOUSE
NC score	0.019268 (rank : 74)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	86	Target Neighborhood Hits	1225	Shared Neighborhood Hits	35
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

STXB4_MOUSE
NC score	0.018996 (rank : 75)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	86	Target Neighborhood Hits	629	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TPM2_MOUSE
NC score	0.018422 (rank : 76)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	86	Target Neighborhood Hits	676	Shared Neighborhood Hits	30
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

MYH9_MOUSE
NC score	0.018370 (rank : 77)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	86	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

STXB4_HUMAN
NC score	0.018056 (rank : 78)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	86	Target Neighborhood Hits	616	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TPM3_HUMAN
NC score	0.017977 (rank : 79)	θ value	0.47712 (rank : 52)
Query Neighborhood Hits	86	Target Neighborhood Hits	689	Shared Neighborhood Hits	28
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

MYH9_HUMAN
NC score	0.017733 (rank : 80)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	86	Target Neighborhood Hits	1762	Shared Neighborhood Hits	38
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PLSB_HUMAN
NC score	0.017659 (rank : 81)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	86	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HCL2, Q5VW51	Gene names	GPAM, KIAA1560
Domain Architecture
Description	Glycerol-3-phosphate acyltransferase, mitochondrial precursor (EC 2.3.1.15) (GPAT).

MYH14_HUMAN
NC score	0.017312 (rank : 82)	θ value	0.21417 (rank : 46)
Query Neighborhood Hits	86	Target Neighborhood Hits	995	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH10_HUMAN
NC score	0.016749 (rank : 83)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	86	Target Neighborhood Hits	1620	Shared Neighborhood Hits	34
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
NC score	0.016209 (rank : 84)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	86	Target Neighborhood Hits	1612	Shared Neighborhood Hits	34
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

HMMR_HUMAN
NC score	0.016022 (rank : 85)	θ value	1.38821 (rank : 58)
Query Neighborhood Hits	86	Target Neighborhood Hits	1082	Shared Neighborhood Hits	31
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

SYCP1_MOUSE
NC score	0.015950 (rank : 86)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	86	Target Neighborhood Hits	1456	Shared Neighborhood Hits	39
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

KTN1_MOUSE
NC score	0.015110 (rank : 87)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	86	Target Neighborhood Hits	1324	Shared Neighborhood Hits	34
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MYO5A_MOUSE
NC score	0.014722 (rank : 88)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	86	Target Neighborhood Hits	1117	Shared Neighborhood Hits	35
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5A_HUMAN
NC score	0.014615 (rank : 89)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	86	Target Neighborhood Hits	1092	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

AKAP9_HUMAN
NC score	0.014363 (rank : 90)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	86	Target Neighborhood Hits	1710	Shared Neighborhood Hits	39
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

KTN1_HUMAN
NC score	0.013373 (rank : 91)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	86	Target Neighborhood Hits	1197	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

CYTSA_HUMAN
NC score	0.012444 (rank : 92)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	86	Target Neighborhood Hits	1138	Shared Neighborhood Hits	32
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
NC score	0.011420 (rank : 93)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	86	Target Neighborhood Hits	1104	Shared Neighborhood Hits	31
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

REST_HUMAN
NC score	0.010601 (rank : 94)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	86	Target Neighborhood Hits	1605	Shared Neighborhood Hits	37
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

MAP9_MOUSE
NC score	0.010542 (rank : 95)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	86	Target Neighborhood Hits	529	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

GOGA4_HUMAN
NC score	0.009836 (rank : 96)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	86	Target Neighborhood Hits	2034	Shared Neighborhood Hits	37
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SNX5_HUMAN
NC score	0.009005 (rank : 97)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5X3, Q52LC4, Q9BWP0	Gene names	SNX5
Domain Architecture
Description	Sorting nexin-5.

PK3CB_MOUSE
NC score	0.007246 (rank : 98)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	86	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

A16L1_MOUSE
NC score	0.006947 (rank : 99)	θ value	2.36792 (rank : 65)
Query Neighborhood Hits	86	Target Neighborhood Hits	776	Shared Neighborhood Hits	26
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

GBP1_HUMAN
NC score	0.006153 (rank : 100)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	86	Target Neighborhood Hits	339	Shared Neighborhood Hits	21
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

TITIN_HUMAN
NC score	0.001602 (rank : 101)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	86	Target Neighborhood Hits	2923	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).