Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : RPGF4_MOUSE

For an explanation of this page, click here

RPGF4_MOUSE
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RPGF3_HUMAN
θ value	0 (rank : 1)	NC score	0.971134 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	56	Shared Neighborhood Hits	42
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	0 (rank : 2)	NC score	0.965589 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF4_HUMAN
θ value	0 (rank : 3)	NC score	0.998742 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	88	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_MOUSE
θ value	2.03989e-169 (rank : 5)	NC score	0.935258 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	85	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	1.42914e-130 (rank : 6)	NC score	0.926222 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF2_HUMAN
θ value	2.76489e-41 (rank : 7)	NC score	0.697747 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	242	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
θ value	1.3722e-40 (rank : 8)	NC score	0.676347 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF1_HUMAN
θ value	2.96777e-27 (rank : 9)	NC score	0.704876 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

GNRP_HUMAN
θ value	3.51386e-20 (rank : 10)	NC score	0.519281 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	239	Shared Neighborhood Hits	26
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_HUMAN
θ value	4.58923e-20 (rank : 11)	NC score	0.520910 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
θ value	5.99374e-20 (rank : 12)	NC score	0.520960 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

GNRP_MOUSE
θ value	1.47631e-18 (rank : 13)	NC score	0.505199 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS2_HUMAN
θ value	1.63225e-17 (rank : 14)	NC score	0.533390 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	1.33837e-11 (rank : 15)	NC score	0.491338 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

PREX1_HUMAN
θ value	1.9326e-10 (rank : 16)	NC score	0.200895 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

KAP1_MOUSE
θ value	1.06045e-08 (rank : 17)	NC score	0.342088 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_HUMAN
θ value	1.38499e-08 (rank : 18)	NC score	0.344577 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

RGL1_HUMAN
θ value	1.80886e-08 (rank : 19)	NC score	0.460391 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	3.08544e-08 (rank : 20)	NC score	0.428497 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

KGP2_HUMAN
θ value	5.26297e-08 (rank : 21)	NC score	0.082737 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CT152_HUMAN
θ value	6.87365e-08 (rank : 22)	NC score	0.365849 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

KGP2_MOUSE
θ value	6.87365e-08 (rank : 23)	NC score	0.082534 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	1029	Shared Neighborhood Hits	25
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

GNDS_MOUSE
θ value	1.99992e-07 (rank : 24)	NC score	0.433756 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GP155_HUMAN
θ value	3.41135e-07 (rank : 25)	NC score	0.218179 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

KAP0_HUMAN
θ value	7.59969e-07 (rank : 26)	NC score	0.323355 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP0_MOUSE
θ value	9.92553e-07 (rank : 27)	NC score	0.323583 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

GNDS_HUMAN
θ value	1.29631e-06 (rank : 28)	NC score	0.418351 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

CT152_MOUSE
θ value	1.69304e-06 (rank : 29)	NC score	0.352593 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

RGL2_MOUSE
θ value	6.43352e-06 (rank : 30)	NC score	0.421390 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_HUMAN
θ value	1.09739e-05 (rank : 31)	NC score	0.415920 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

KGP1A_HUMAN
θ value	1.43324e-05 (rank : 32)	NC score	0.075198 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	901	Shared Neighborhood Hits	31
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	2.44474e-05 (rank : 33)	NC score	0.075093 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	921	Shared Neighborhood Hits	30
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	2.44474e-05 (rank : 34)	NC score	0.074833 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	922	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

FYV1_HUMAN
θ value	3.19293e-05 (rank : 35)	NC score	0.119593 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	217	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	3.19293e-05 (rank : 36)	NC score	0.120919 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

KAP2_HUMAN
θ value	9.29e-05 (rank : 37)	NC score	0.300980 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	48	Shared Neighborhood Hits	25
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_HUMAN
θ value	0.000121331 (rank : 38)	NC score	0.296380 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	40	Shared Neighborhood Hits	26
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_MOUSE
θ value	0.000158464 (rank : 39)	NC score	0.296905 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP2_MOUSE
θ value	0.00020696 (rank : 40)	NC score	0.302579 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

SH2D3_MOUSE
θ value	0.00869519 (rank : 41)	NC score	0.130302 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

RGDSR_HUMAN
θ value	0.0113563 (rank : 42)	NC score	0.353475 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

CNGB1_HUMAN
θ value	0.0193708 (rank : 43)	NC score	0.117524 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	222	Shared Neighborhood Hits	30
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

DEPD5_HUMAN
θ value	0.0193708 (rank : 44)	NC score	0.086152 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	40	Shared Neighborhood Hits	14
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

CNGB3_HUMAN
θ value	0.0431538 (rank : 45)	NC score	0.097975 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	206	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

PLEK2_HUMAN
θ value	0.0431538 (rank : 46)	NC score	0.069084 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

SH2D3_HUMAN
θ value	0.0431538 (rank : 47)	NC score	0.121286 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

CNGB3_MOUSE
θ value	0.0961366 (rank : 48)	NC score	0.104582 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	74	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGA2_MOUSE
θ value	0.279714 (rank : 49)	NC score	0.073430 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	86	Shared Neighborhood Hits	28
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

HCN2_HUMAN
θ value	0.279714 (rank : 50)	NC score	0.076315 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	369	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

HCN2_MOUSE
θ value	0.279714 (rank : 51)	NC score	0.077429 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	278	Shared Neighborhood Hits	28
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

DEPD5_MOUSE
θ value	0.365318 (rank : 52)	NC score	0.066720 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

DVL1_MOUSE
θ value	0.365318 (rank : 53)	NC score	0.064517 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	18
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

KCNH7_MOUSE
θ value	0.365318 (rank : 54)	NC score	0.049220 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

DVL1_HUMAN
θ value	0.47712 (rank : 55)	NC score	0.057716 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

CHM1A_MOUSE
θ value	0.813845 (rank : 56)	NC score	0.040868 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q921W0, Q3TW57	Gene names	Pcoln3, Chmp1, Chmp1a
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a).

DVL1L_HUMAN
θ value	0.813845 (rank : 57)	NC score	0.059708 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

UBP26_HUMAN
θ value	1.06291 (rank : 58)	NC score	0.016583 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	108	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

CI039_HUMAN
θ value	1.81305 (rank : 59)	NC score	0.003862 (rank : 91)
Query Neighborhood Hits	80	Target Neighborhood Hits	1171	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

KCNH7_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.048738 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

PLEK2_MOUSE
θ value	1.81305 (rank : 61)	NC score	0.050913 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

STX1C_HUMAN
θ value	1.81305 (rank : 62)	NC score	0.014783 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	270	Shared Neighborhood Hits	8
SwissProt Accessions	P61266	Gene names	STX1B2
Domain Architecture
Description	Syntaxin-1B2.

STX1C_MOUSE
θ value	1.81305 (rank : 63)	NC score	0.014783 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	270	Shared Neighborhood Hits	8
SwissProt Accessions	P61264, P32853	Gene names	Stx1b2, Stx1b
Domain Architecture
Description	Syntaxin-1B2 (Syntaxin 1B).

KCNH6_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.046732 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

DVL3_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.056156 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	194	Shared Neighborhood Hits	19
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

DVL3_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.054880 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

CYTSA_HUMAN
θ value	4.03905 (rank : 67)	NC score	0.007292 (rank : 88)
Query Neighborhood Hits	80	Target Neighborhood Hits	1138	Shared Neighborhood Hits	14
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

KCNH2_HUMAN
θ value	4.03905 (rank : 68)	NC score	0.043619 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

KCNH2_MOUSE
θ value	4.03905 (rank : 69)	NC score	0.043636 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	165	Shared Neighborhood Hits	20
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

STX1A_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.013463 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	266	Shared Neighborhood Hits	9
SwissProt Accessions	Q16623, O15447, O15448, Q12936, Q9BPZ6	Gene names	STX1A, STX1
Domain Architecture
Description	Syntaxin-1A (Neuron-specific antigen HPC-1).

UBP26_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.017570 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

CHM1A_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.025664 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HD42, Q14468, Q15779, Q96G31	Gene names	PCOLN3, CHMP1, CHMP1A, KIAA0047, PRSM1
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting 46-1) (Vps46-1) (hVps46-1).

CYTSA_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.005781 (rank : 89)
Query Neighborhood Hits	80	Target Neighborhood Hits	1104	Shared Neighborhood Hits	11
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DYH9_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.008029 (rank : 87)
Query Neighborhood Hits	80	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

RRBP1_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.002555 (rank : 92)
Query Neighborhood Hits	80	Target Neighborhood Hits	1306	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

BPAEA_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.002246 (rank : 93)
Query Neighborhood Hits	80	Target Neighborhood Hits	1480	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DVL2_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.049312 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	223	Shared Neighborhood Hits	16
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.049261 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	233	Shared Neighborhood Hits	17
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

STX1A_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.012424 (rank : 86)
Query Neighborhood Hits	80	Target Neighborhood Hits	261	Shared Neighborhood Hits	9
SwissProt Accessions	O35526	Gene names	Stx1a
Domain Architecture
Description	Syntaxin-1A (Neuron-specific antigen HPC-1).

USP9X_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.005459 (rank : 90)
Query Neighborhood Hits	80	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

ARHG4_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.050537 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.050102 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CNGA1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.069911 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	149	Shared Neighborhood Hits	28
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.066648 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.065722 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.065060 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

ECT2_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.050254 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

HCN1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.057258 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	120	Shared Neighborhood Hits	25
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.056694 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	172	Shared Neighborhood Hits	25
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

HCN3_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.056127 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.055988 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

HCN4_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.061258 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	303	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

HCN4_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.064503 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	284	Shared Neighborhood Hits	27
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

Hits sorted by NC score

RPGF4_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF4_HUMAN
NC score	0.998742 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	88	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF3_HUMAN
NC score	0.971134 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	56	Shared Neighborhood Hits	42
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.965589 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

RPGF5_MOUSE
NC score	0.935258 (rank : 5)	θ value	2.03989e-169 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	85	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
NC score	0.926222 (rank : 6)	θ value	1.42914e-130 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	25
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF1_HUMAN
NC score	0.704876 (rank : 7)	θ value	2.96777e-27 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	262	Shared Neighborhood Hits	23
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF2_HUMAN
NC score	0.697747 (rank : 8)	θ value	2.76489e-41 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	242	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF6_HUMAN
NC score	0.676347 (rank : 9)	θ value	1.3722e-40 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	266	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SOS2_HUMAN
NC score	0.533390 (rank : 10)	θ value	1.63225e-17 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	193	Shared Neighborhood Hits	23
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_MOUSE
NC score	0.520960 (rank : 11)	θ value	5.99374e-20 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	23
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.520910 (rank : 12)	θ value	4.58923e-20 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	274	Shared Neighborhood Hits	23
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GNRP_HUMAN
NC score	0.519281 (rank : 13)	θ value	3.51386e-20 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	239	Shared Neighborhood Hits	26
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.505199 (rank : 14)	θ value	1.47631e-18 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	191	Shared Neighborhood Hits	25
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRP3_HUMAN
NC score	0.491338 (rank : 15)	θ value	1.33837e-11 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RGL1_HUMAN
NC score	0.460391 (rank : 16)	θ value	1.80886e-08 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.433756 (rank : 17)	θ value	1.99992e-07 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL1_MOUSE
NC score	0.428497 (rank : 18)	θ value	3.08544e-08 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL2_MOUSE
NC score	0.421390 (rank : 19)	θ value	6.43352e-06 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.418351 (rank : 20)	θ value	1.29631e-06 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	201	Shared Neighborhood Hits	23
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.415920 (rank : 21)	θ value	1.09739e-05 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

CT152_HUMAN
NC score	0.365849 (rank : 22)	θ value	6.87365e-08 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	30	Shared Neighborhood Hits	23
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

RGDSR_HUMAN
NC score	0.353475 (rank : 23)	θ value	0.0113563 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

CT152_MOUSE
NC score	0.352593 (rank : 24)	θ value	1.69304e-06 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9D5U8, Q8R083	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf152 homolog.

KAP1_HUMAN
NC score	0.344577 (rank : 25)	θ value	1.38499e-08 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	P31321	Gene names	PRKAR1B
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP1_MOUSE
NC score	0.342088 (rank : 26)	θ value	1.06045e-08 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	31
SwissProt Accessions	P12849	Gene names	Prkar1b
Domain Architecture
Description	cAMP-dependent protein kinase type I-beta regulatory subunit.

KAP0_MOUSE
NC score	0.323583 (rank : 27)	θ value	9.92553e-07 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	48	Shared Neighborhood Hits	31
SwissProt Accessions	Q9DBC7, Q3UKU7, Q9JHR5, Q9JHR6	Gene names	Prkar1a
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit.

KAP0_HUMAN
NC score	0.323355 (rank : 28)	θ value	7.59969e-07 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	52	Shared Neighborhood Hits	31
SwissProt Accessions	P10644, Q567S7	Gene names	PRKAR1A, PKR1, PRKAR1
Domain Architecture
Description	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue- specific extinguisher 1) (TSE1).

KAP2_MOUSE
NC score	0.302579 (rank : 29)	θ value	0.00020696 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	P12367	Gene names	Prkar2a
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP2_HUMAN
NC score	0.300980 (rank : 30)	θ value	9.29e-05 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	48	Shared Neighborhood Hits	25
SwissProt Accessions	P13861, Q16823	Gene names	PRKAR2A, PKR2, PRKAR2
Domain Architecture
Description	cAMP-dependent protein kinase type II-alpha regulatory subunit.

KAP3_MOUSE
NC score	0.296905 (rank : 31)	θ value	0.000158464 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	P31324, Q3UTZ1, Q80ZM4, Q8BRZ7	Gene names	Prkar2b
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

KAP3_HUMAN
NC score	0.296380 (rank : 32)	θ value	0.000121331 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	40	Shared Neighborhood Hits	26
SwissProt Accessions	P31323	Gene names	PRKAR2B
Domain Architecture
Description	cAMP-dependent protein kinase type II-beta regulatory subunit.

GP155_HUMAN
NC score	0.218179 (rank : 33)	θ value	3.41135e-07 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z3F1, Q53SJ3, Q53TA8, Q69YG8, Q86SP9, Q8N261, Q8N639, Q8N8K3, Q96MV6	Gene names	GPR155, PGR22
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR155 (G-protein coupled receptor PGR22).

PREX1_HUMAN
NC score	0.200895 (rank : 34)	θ value	1.9326e-10 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	177	Shared Neighborhood Hits	26
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

SH2D3_MOUSE
NC score	0.130302 (rank : 35)	θ value	0.00869519 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	174	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
NC score	0.121286 (rank : 36)	θ value	0.0431538 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

FYV1_MOUSE
NC score	0.120919 (rank : 37)	θ value	3.19293e-05 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.119593 (rank : 38)	θ value	3.19293e-05 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	217	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

CNGB1_HUMAN
NC score	0.117524 (rank : 39)	θ value	0.0193708 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	222	Shared Neighborhood Hits	30
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CNGB3_MOUSE
NC score	0.104582 (rank : 40)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	74	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJZ9	Gene names	Cngb3, Cng6
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel subunit CNG6).

CNGB3_HUMAN
NC score	0.097975 (rank : 41)	θ value	0.0431538 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	206	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQW8, Q9NRE9	Gene names	CNGB3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel beta 3 (CNG channel beta 3) (Cyclic nucleotide-gated channel beta 3) (Cone photoreceptor cGMP- gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit).

DEPD5_HUMAN
NC score	0.086152 (rank : 42)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	40	Shared Neighborhood Hits	14
SwissProt Accessions	O75140, Q5K3V5, Q5THY9, Q5THZ0, Q5THZ1, Q5THZ3, Q68DR1, Q6MZX3, Q6PEZ1, Q9UGV8, Q9UH13	Gene names	DEPDC5, KIAA0645
Domain Architecture
Description	DEP domain-containing protein 5.

KGP2_HUMAN
NC score	0.082737 (rank : 43)	θ value	5.26297e-08 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	1023	Shared Neighborhood Hits	26
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.082534 (rank : 44)	θ value	6.87365e-08 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	1029	Shared Neighborhood Hits	25
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

HCN2_MOUSE
NC score	0.077429 (rank : 45)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	278	Shared Neighborhood Hits	28
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HCN2_HUMAN
NC score	0.076315 (rank : 46)	θ value	0.279714 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	369	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

KGP1A_HUMAN
NC score	0.075198 (rank : 47)	θ value	1.43324e-05 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	901	Shared Neighborhood Hits	31
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
NC score	0.075093 (rank : 48)	θ value	2.44474e-05 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	921	Shared Neighborhood Hits	30
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
NC score	0.074833 (rank : 49)	θ value	2.44474e-05 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	922	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CNGA2_MOUSE
NC score	0.073430 (rank : 50)	θ value	0.279714 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	86	Shared Neighborhood Hits	28
SwissProt Accessions	Q62398	Gene names	Cnga2, Cncg2, Cncg4
Domain Architecture
Description	Cyclic nucleotide-gated olfactory channel (Cyclic nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2).

CNGA1_HUMAN
NC score	0.069911 (rank : 51)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	149	Shared Neighborhood Hits	28
SwissProt Accessions	P29973, Q16279, Q16485	Gene names	CNGA1, CNCG, CNCG1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

PLEK2_HUMAN
NC score	0.069084 (rank : 52)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

DEPD5_MOUSE
NC score	0.066720 (rank : 53)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	P61460	Gene names	Depdc5, Kiaa0645
Domain Architecture
Description	DEP domain-containing protein 5.

CNGA1_MOUSE
NC score	0.066648 (rank : 54)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	P29974, Q60776	Gene names	Cnga1, Cncg, Cncg1
Domain Architecture
Description	cGMP-gated cation channel alpha 1 (CNG channel alpha 1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel alpha 1) (Cyclic nucleotide-gated channel, photoreceptor) (Cyclic nucleotide-gated cation channel 1) (Rod photoreceptor cGMP-gated channel subunit alpha).

CNGA3_HUMAN
NC score	0.065722 (rank : 55)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	27
SwissProt Accessions	Q16281, Q9UP64	Gene names	CNGA3, CNCG3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

CNGA3_MOUSE
NC score	0.065060 (rank : 56)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	80	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JJZ8, Q9WV01	Gene names	Cnga3, Cng3
Domain Architecture
Description	Cyclic nucleotide-gated cation channel alpha 3 (CNG channel alpha 3) (CNG-3) (CNG3) (Cyclic nucleotide-gated channel alpha 3) (Cone photoreceptor cGMP-gated channel subunit alpha).

DVL1_MOUSE
NC score	0.064517 (rank : 57)	θ value	0.365318 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	18
SwissProt Accessions	P51141, Q60868	Gene names	Dvl1, Dvl
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

HCN4_MOUSE
NC score	0.064503 (rank : 58)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	80	Target Neighborhood Hits	284	Shared Neighborhood Hits	27
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN4_HUMAN
NC score	0.061258 (rank : 59)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	80	Target Neighborhood Hits	303	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

DVL1L_HUMAN
NC score	0.059708 (rank : 60)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	16
SwissProt Accessions	P54792	Gene names	DVL1L1, DVL, DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1-like (Dishevelled- 1-like) (DSH homolog 1-like).

DVL1_HUMAN
NC score	0.057716 (rank : 61)	θ value	0.47712 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	O14640	Gene names	DVL1
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1).

HCN1_HUMAN
NC score	0.057258 (rank : 62)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	80	Target Neighborhood Hits	120	Shared Neighborhood Hits	25
SwissProt Accessions	O60741	Gene names	HCN1, BCNG1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1).

HCN1_MOUSE
NC score	0.056694 (rank : 63)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	80	Target Neighborhood Hits	172	Shared Neighborhood Hits	25
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

DVL3_HUMAN
NC score	0.056156 (rank : 64)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	194	Shared Neighborhood Hits	19
SwissProt Accessions	Q92997, O14642, Q13531, Q8N5E9, Q92607	Gene names	DVL3, KIAA0208
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

HCN3_HUMAN
NC score	0.056127 (rank : 65)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	80	Target Neighborhood Hits	99	Shared Neighborhood Hits	26
SwissProt Accessions	Q9P1Z3, Q4VX12, Q8N6W6, Q9BWQ2	Gene names	HCN3, KIAA1535
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.

HCN3_MOUSE
NC score	0.055988 (rank : 66)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	O88705	Gene names	Hcn3, Hac3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Hyperpolarization-activated cation channel 3) (HAC-3).

DVL3_MOUSE
NC score	0.054880 (rank : 67)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	19
SwissProt Accessions	Q61062	Gene names	Dvl3
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3).

PLEK2_MOUSE
NC score	0.050913 (rank : 68)	θ value	1.81305 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

ARHG4_HUMAN
NC score	0.050537 (rank : 69)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ECT2_HUMAN
NC score	0.050254 (rank : 70)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	80	Target Neighborhood Hits	98	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG9_MOUSE
NC score	0.050102 (rank : 71)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

DVL2_HUMAN
NC score	0.049312 (rank : 72)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	223	Shared Neighborhood Hits	16
SwissProt Accessions	O14641	Gene names	DVL2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

DVL2_MOUSE
NC score	0.049261 (rank : 73)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	233	Shared Neighborhood Hits	17
SwissProt Accessions	Q60838	Gene names	Dvl2
Domain Architecture
Description	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2).

KCNH7_MOUSE
NC score	0.049220 (rank : 74)	θ value	0.365318 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ER47	Gene names	Kcnh7, Erg3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (Ether-a-go-go-related protein 3) (Eag-related protein 3).

KCNH7_HUMAN
NC score	0.048738 (rank : 75)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

KCNH6_HUMAN
NC score	0.046732 (rank : 76)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	222	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

KCNH2_MOUSE
NC score	0.043636 (rank : 77)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	165	Shared Neighborhood Hits	20
SwissProt Accessions	O35219, O35220, O35221, O35989	Gene names	Kcnh2, Erg, Merg1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (ERG1) (MERG) (Merg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1).

KCNH2_HUMAN
NC score	0.043619 (rank : 78)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	Q12809, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0	Gene names	KCNH2, ERG, ERG1, HERG, HERG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 2 (Voltage-gated potassium channel subunit Kv11.1) (Ether-a-go-go-related gene potassium channel 1) (H-ERG) (Erg1) (Ether-a-go-go-related protein 1) (Eag-related protein 1) (eag homolog).

CHM1A_MOUSE
NC score	0.040868 (rank : 79)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	Q921W0, Q3TW57	Gene names	Pcoln3, Chmp1, Chmp1a
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a).

CHM1A_HUMAN
NC score	0.025664 (rank : 80)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HD42, Q14468, Q15779, Q96G31	Gene names	PCOLN3, CHMP1, CHMP1A, KIAA0047, PRSM1
Domain Architecture	No domain graphic available
Description	Charged multivesicular body protein 1a (Chromatin-modifying protein 1a) (CHMP1a) (Vacuolar protein sorting 46-1) (Vps46-1) (hVps46-1).

UBP26_MOUSE
NC score	0.017570 (rank : 81)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MX1	Gene names	Usp26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

UBP26_HUMAN
NC score	0.016583 (rank : 82)	θ value	1.06291 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	108	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXU7	Gene names	USP26
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 26 (EC 3.1.2.15) (Ubiquitin thioesterase 26) (Ubiquitin-specific-processing protease 26) (Deubiquitinating enzyme 26).

STX1C_HUMAN
NC score	0.014783 (rank : 83)	θ value	1.81305 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	270	Shared Neighborhood Hits	8
SwissProt Accessions	P61266	Gene names	STX1B2
Domain Architecture
Description	Syntaxin-1B2.

STX1C_MOUSE
NC score	0.014783 (rank : 84)	θ value	1.81305 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	270	Shared Neighborhood Hits	8
SwissProt Accessions	P61264, P32853	Gene names	Stx1b2, Stx1b
Domain Architecture
Description	Syntaxin-1B2 (Syntaxin 1B).

STX1A_HUMAN
NC score	0.013463 (rank : 85)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	266	Shared Neighborhood Hits	9
SwissProt Accessions	Q16623, O15447, O15448, Q12936, Q9BPZ6	Gene names	STX1A, STX1
Domain Architecture
Description	Syntaxin-1A (Neuron-specific antigen HPC-1).

STX1A_MOUSE
NC score	0.012424 (rank : 86)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	261	Shared Neighborhood Hits	9
SwissProt Accessions	O35526	Gene names	Stx1a
Domain Architecture
Description	Syntaxin-1A (Neuron-specific antigen HPC-1).

DYH9_HUMAN
NC score	0.008029 (rank : 87)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	291	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYC9, O95494, Q9NQ28	Gene names	DNAH9, DNAH17L, DNAL1
Domain Architecture
Description	Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).

CYTSA_HUMAN
NC score	0.007292 (rank : 88)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	1138	Shared Neighborhood Hits	14
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
NC score	0.005781 (rank : 89)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	1104	Shared Neighborhood Hits	11
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

USP9X_MOUSE
NC score	0.005459 (rank : 90)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

CI039_HUMAN
NC score	0.003862 (rank : 91)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	1171	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

RRBP1_HUMAN
NC score	0.002555 (rank : 92)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	1306	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

BPAEA_MOUSE
NC score	0.002246 (rank : 93)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	1480	Shared Neighborhood Hits	14
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).