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Network neighborhood for query Sequence : RGL1_HUMAN

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RGL1_HUMAN
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RGL1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	0 (rank : 2)	NC score	0.996409 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	32
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
θ value	3.51195e-137 (rank : 3)	NC score	0.946363 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GNDS_HUMAN
θ value	3.6343e-134 (rank : 4)	NC score	0.929629 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
θ value	1.7756e-72 (rank : 5)	NC score	0.930711 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGL2_MOUSE
θ value	2.65329e-68 (rank : 6)	NC score	0.924832 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
θ value	1.7238e-59 (rank : 7)	NC score	0.911679 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

GNRP_HUMAN
θ value	8.06329e-33 (rank : 8)	NC score	0.622290 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	1.12775e-26 (rank : 9)	NC score	0.605110 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

SOS1_MOUSE
θ value	1.12775e-26 (rank : 10)	NC score	0.609755 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
θ value	7.30988e-26 (rank : 11)	NC score	0.605666 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS2_HUMAN
θ value	1.05554e-24 (rank : 12)	NC score	0.634584 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GRP3_HUMAN
θ value	2.97466e-19 (rank : 13)	NC score	0.551251 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF1_HUMAN
θ value	1.92812e-18 (rank : 14)	NC score	0.713239 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RPGF6_HUMAN
θ value	1.09485e-13 (rank : 15)	NC score	0.512163 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF2_HUMAN
θ value	2.0648e-12 (rank : 16)	NC score	0.526666 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF4_HUMAN
θ value	8.11959e-09 (rank : 17)	NC score	0.464510 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
θ value	1.80886e-08 (rank : 18)	NC score	0.460391 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF5_MOUSE
θ value	1.80886e-08 (rank : 19)	NC score	0.499415 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF5_HUMAN
θ value	5.26297e-08 (rank : 20)	NC score	0.513142 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF3_HUMAN
θ value	0.000121331 (rank : 21)	NC score	0.413219 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
θ value	0.000121331 (rank : 22)	NC score	0.372076 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

AP180_HUMAN
θ value	0.0736092 (rank : 23)	NC score	0.057441 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
θ value	0.0736092 (rank : 24)	NC score	0.056778 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

TIAM1_HUMAN
θ value	0.125558 (rank : 25)	NC score	0.073400 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	10
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	0.163984 (rank : 26)	NC score	0.070984 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	205	Shared Neighborhood Hits	11
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

CD2L7_HUMAN
θ value	0.813845 (rank : 27)	NC score	0.002546 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	1275	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

BCAR3_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.020616 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BRCA2_HUMAN
θ value	1.38821 (rank : 29)	NC score	0.026069 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

CF152_HUMAN
θ value	1.38821 (rank : 30)	NC score	0.024381 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	704	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

BCAR3_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.024211 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

POSTN_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.015550 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q15063, Q15064, Q5VSY5, Q8IZF9	Gene names	POSTN, OSF2
Domain Architecture
Description	Periostin precursor (PN) (Osteoblast-specific factor 2) (OSF-2).

K1543_MOUSE
θ value	2.36792 (rank : 33)	NC score	0.021540 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	497	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

TMCC1_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.020037 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	315	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TMCC1_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.017723 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	337	Shared Neighborhood Hits	5
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

BPTF_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.004504 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	786	Shared Neighborhood Hits	6
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

LPHN2_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.002944 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	136	Shared Neighborhood Hits	3
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

OR1J1_HUMAN
θ value	6.88961 (rank : 38)	NC score	-0.002619 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NGS3, Q6IF10, Q96R88	Gene names	OR1J1
Domain Architecture
Description	Olfactory receptor 1J1 (Olfactory receptor OR9-18).

ADA22_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.001512 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

CJ078_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.008636 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	559	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

EPC1_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.006429 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C9X6, Q9Z299	Gene names	Epc1
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 1.

KHK_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.015962 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P50053, Q99532, Q9BRJ3, Q9UMN1	Gene names	KHK
Domain Architecture
Description	Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase).

VRK3_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.004668 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	342	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ARHG4_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.056414 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.051264 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.056101 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.056380 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	234	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CB027_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.056110 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	29	Shared Neighborhood Hits	1
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

CT152_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.052009 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

ECT2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.064169 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.061028 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD3_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.052158 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	249	Shared Neighborhood Hits	7
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.051666 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	219	Shared Neighborhood Hits	7
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.050402 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.054514 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PREX1_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.091384 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

Hits sorted by NC score

RGL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
NC score	0.996409 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	32
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

GNDS_MOUSE
NC score	0.946363 (rank : 3)	θ value	3.51195e-137 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_HUMAN
NC score	0.930711 (rank : 4)	θ value	1.7756e-72 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	45	Shared Neighborhood Hits	21
SwissProt Accessions	O15211, Q9Y3F3	Gene names	RGL2, RAB2L
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

GNDS_HUMAN
NC score	0.929629 (rank : 5)	θ value	3.6343e-134 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

RGL2_MOUSE
NC score	0.924832 (rank : 6)	θ value	2.65329e-68 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	51	Shared Neighborhood Hits	21
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

RGDSR_HUMAN
NC score	0.911679 (rank : 7)	θ value	1.7238e-59 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IZJ4	Gene names	RGR
Domain Architecture
Description	Ral-GDS-related protein (hRGR).

RPGF1_HUMAN
NC score	0.713239 (rank : 8)	θ value	1.92812e-18 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	262	Shared Neighborhood Hits	24
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

SOS2_HUMAN
NC score	0.634584 (rank : 9)	θ value	1.05554e-24 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	193	Shared Neighborhood Hits	24
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

GNRP_HUMAN
NC score	0.622290 (rank : 10)	θ value	8.06329e-33 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

SOS1_MOUSE
NC score	0.609755 (rank : 11)	θ value	1.12775e-26 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	281	Shared Neighborhood Hits	22
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SOS1_HUMAN
NC score	0.605666 (rank : 12)	θ value	7.30988e-26 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	274	Shared Neighborhood Hits	22
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

GNRP_MOUSE
NC score	0.605110 (rank : 13)	θ value	1.12775e-26 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	191	Shared Neighborhood Hits	24
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRP3_HUMAN
NC score	0.551251 (rank : 14)	θ value	2.97466e-19 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	131	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

RPGF2_HUMAN
NC score	0.526666 (rank : 15)	θ value	2.0648e-12 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y4G8	Gene names	RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1
Domain Architecture	No domain graphic available
Description	Rap guanine nucleotide exchange factor 2 (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF).

RPGF5_HUMAN
NC score	0.513142 (rank : 16)	θ value	5.26297e-08 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	22
SwissProt Accessions	Q92565, Q8IXU5	Gene names	RAPGEF5, GFR, KIAA0277, MRGEF
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (Related to Epac) (Repac) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF6_HUMAN
NC score	0.512163 (rank : 17)	θ value	1.09485e-13 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	266	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

RPGF5_MOUSE
NC score	0.499415 (rank : 18)	θ value	1.80886e-08 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C0Q9, Q8BJJ9, Q8C0R5	Gene names	Rapgef5, Gfr, Kiaa0277, Mrgef
Domain Architecture
Description	Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF).

RPGF4_HUMAN
NC score	0.464510 (rank : 19)	θ value	8.11959e-09 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	88	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WZA2, O95636, Q8IXK6, Q8TAA4	Gene names	RAPGEF4, CGEF2, EPAC2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2).

RPGF4_MOUSE
NC score	0.460391 (rank : 20)	θ value	1.80886e-08 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9EQZ6, Q8VIP9, Q9CW52, Q9Z1P0	Gene names	Rapgef4, Cgef2, Epac2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 4 (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) (Exchange factor directly activated by cAMP 2) (Epac 2) (cAMP-dependent Rap1 guanine-nucleotide exchange factor).

RPGF3_HUMAN
NC score	0.413219 (rank : 21)	θ value	0.000121331 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	O95398, O95634, Q8WVN0	Gene names	RAPGEF3, CGEF1, EPAC, EPAC1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP).

RPGF3_MOUSE
NC score	0.372076 (rank : 22)	θ value	0.000121331 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	54	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VCC8, Q8BZK9, Q8R1R1	Gene names	Rapgef3, Epac, Epac1
Domain Architecture
Description	Rap guanine nucleotide exchange factor 3 (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) (Exchange factor directly activated by cAMP 1) (Epac 1).

PREX1_HUMAN
NC score	0.091384 (rank : 23)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	43	Target Neighborhood Hits	177	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TIAM1_HUMAN
NC score	0.073400 (rank : 24)	θ value	0.125558 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	10
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.070984 (rank : 25)	θ value	0.163984 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	205	Shared Neighborhood Hits	11
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ECT2_HUMAN
NC score	0.064169 (rank : 26)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	43	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
NC score	0.061028 (rank : 27)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	43	Target Neighborhood Hits	98	Shared Neighborhood Hits	7
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

AP180_HUMAN
NC score	0.057441 (rank : 28)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	O60641, Q5JX13, Q68DL9, Q6P9D3, Q9NTY7	Gene names	SNAP91, KIAA0656
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein).

AP180_MOUSE
NC score	0.056778 (rank : 29)	θ value	0.0736092 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	194	Shared Neighborhood Hits	4
SwissProt Accessions	Q61548, Q61547	Gene names	Snap91
Domain Architecture
Description	Clathrin coat assembly protein AP180 (Clathrin coat-associated protein AP180) (91 kDa synaptosomal-associated protein) (Phosphoprotein F1- 20).

ARHG4_HUMAN
NC score	0.056414 (rank : 30)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	242	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_MOUSE
NC score	0.056380 (rank : 31)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	234	Shared Neighborhood Hits	6
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CB027_HUMAN
NC score	0.056110 (rank : 32)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	43	Target Neighborhood Hits	29	Shared Neighborhood Hits	1
SwissProt Accessions	Q580R0, O43575, Q52M10, Q86XG2	Gene names	C2orf27
Domain Architecture	No domain graphic available
Description	Protein C2orf27.

ARHG9_HUMAN
NC score	0.056101 (rank : 33)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	235	Shared Neighborhood Hits	6
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

NGEF_HUMAN
NC score	0.054514 (rank : 34)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	43	Target Neighborhood Hits	166	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

FGD3_HUMAN
NC score	0.052158 (rank : 35)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	43	Target Neighborhood Hits	249	Shared Neighborhood Hits	7
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

CT152_HUMAN
NC score	0.052009 (rank : 36)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q96M20, Q5T3S1, Q9BR36, Q9BWY5	Gene names	C20orf152
Domain Architecture
Description	Uncharacterized protein C20orf152.

FGD4_HUMAN
NC score	0.051666 (rank : 37)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	43	Target Neighborhood Hits	219	Shared Neighborhood Hits	7
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ARHG4_MOUSE
NC score	0.051264 (rank : 38)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	185	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FGD4_MOUSE
NC score	0.050402 (rank : 39)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	43	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

BRCA2_HUMAN
NC score	0.026069 (rank : 40)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	202	Shared Neighborhood Hits	4
SwissProt Accessions	P51587, O00183, O15008, Q13879	Gene names	BRCA2, FANCD1
Domain Architecture
Description	Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).

CF152_HUMAN
NC score	0.024381 (rank : 41)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	704	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

BCAR3_MOUSE
NC score	0.024211 (rank : 42)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	127	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

K1543_MOUSE
NC score	0.021540 (rank : 43)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	497	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

BCAR3_HUMAN
NC score	0.020616 (rank : 44)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

TMCC1_MOUSE
NC score	0.020037 (rank : 45)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	315	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZZ6, Q8CEF4	Gene names	Tmcc1, Kiaa0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

TMCC1_HUMAN
NC score	0.017723 (rank : 46)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	337	Shared Neighborhood Hits	5
SwissProt Accessions	O94876, Q68E06, Q8IXM8	Gene names	TMCC1, KIAA0779
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 1.

KHK_HUMAN
NC score	0.015962 (rank : 47)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P50053, Q99532, Q9BRJ3, Q9UMN1	Gene names	KHK
Domain Architecture
Description	Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase).

POSTN_HUMAN
NC score	0.015550 (rank : 48)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q15063, Q15064, Q5VSY5, Q8IZF9	Gene names	POSTN, OSF2
Domain Architecture
Description	Periostin precursor (PN) (Osteoblast-specific factor 2) (OSF-2).

CJ078_MOUSE
NC score	0.008636 (rank : 49)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	559	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

EPC1_MOUSE
NC score	0.006429 (rank : 50)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C9X6, Q9Z299	Gene names	Epc1
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 1.

VRK3_MOUSE
NC score	0.004668 (rank : 51)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	342	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

BPTF_HUMAN
NC score	0.004504 (rank : 52)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	786	Shared Neighborhood Hits	6
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

LPHN2_HUMAN
NC score	0.002944 (rank : 53)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	136	Shared Neighborhood Hits	3
SwissProt Accessions	O95490, O94882, Q5VX76, Q9UKY5, Q9UKY6	Gene names	LPHN2, KIAA0786, LEC1, LPHH1
Domain Architecture
Description	Latrophilin-2 precursor (Calcium-independent alpha-latrotoxin receptor 2) (Latrophilin homolog 1) (Lectomedin-1).

CD2L7_HUMAN
NC score	0.002546 (rank : 54)	θ value	0.813845 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	1275	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

ADA22_MOUSE
NC score	0.001512 (rank : 55)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	225	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

OR1J1_HUMAN
NC score	-0.002619 (rank : 56)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	760	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NGS3, Q6IF10, Q96R88	Gene names	OR1J1
Domain Architecture
Description	Olfactory receptor 1J1 (Olfactory receptor OR9-18).